Pub Date : 2024-09-13DOI: 10.1515/polyeng-2023-0247
Anilkumar Yamala, Jai Shree Kurba, D. Sanjeev Kumar, Ravi Kumar Kanaparthi, Ashok K. Madikonda
Hydrogels possess excellent biological properties that make them ideal for biomedical applications. They are compatible with living cells and tissues because they can swell in the presence of water. In this study, we investigated the stability and biocompatibility of hydrogels. We synthesized and characterized N-acryl glycine (NAG) monomer and then synthesized its copolymer using the miniemulsion-polymerization technique, a soft-hydrogel method. To confirm the morphological properties of the dried hydrogel particles, we used the field emission scanning electron microscopy (FESEM) technique. We also investigated the rheological properties of the hydrogels for different concentrations to evaluate their mechanical strength and gel-like properties. Our findings indicated that the 10 % gel had superior strength and yield strain at all examined temperatures (30 °C, 37 °C, and 40 °C) compared to other concentrated gels. We systematically evaluated the biocompatibility of the hydrogel using three different cell lines: HEK 293T, RAW 264.7, and HeLa. Our cell line studies demonstrated that hydrogels are viable when exposed to a concentration of 0.5 mg/mL. Moreover, cell proliferation was observed at concentrations below 0.25 mg/mL. The MTT assay and rheology results suggest that hydrogel characteristics are more suitable for various biomedical applications, such as drug delivery and tissue engineering.
{"title":"Synthesis, rheology, cytotoxicity and antibacterial studies of N-acrolylglycine-acrylamide copolymer soft nano hydrogel","authors":"Anilkumar Yamala, Jai Shree Kurba, D. Sanjeev Kumar, Ravi Kumar Kanaparthi, Ashok K. Madikonda","doi":"10.1515/polyeng-2023-0247","DOIUrl":"https://doi.org/10.1515/polyeng-2023-0247","url":null,"abstract":"Hydrogels possess excellent biological properties that make them ideal for biomedical applications. They are compatible with living cells and tissues because they can swell in the presence of water. In this study, we investigated the stability and biocompatibility of hydrogels. We synthesized and characterized N-acryl glycine (NAG) monomer and then synthesized its copolymer using the miniemulsion-polymerization technique, a soft-hydrogel method. To confirm the morphological properties of the dried hydrogel particles, we used the field emission scanning electron microscopy (FESEM) technique. We also investigated the rheological properties of the hydrogels for different concentrations to evaluate their mechanical strength and gel-like properties. Our findings indicated that the 10 % gel had superior strength and yield strain at all examined temperatures (30 °C, 37 °C, and 40 °C) compared to other concentrated gels. We systematically evaluated the biocompatibility of the hydrogel using three different cell lines: HEK 293T, RAW 264.7, and HeLa. Our cell line studies demonstrated that hydrogels are viable when exposed to a concentration of 0.5 mg/mL. Moreover, cell proliferation was observed at concentrations below 0.25 mg/mL. The MTT assay and rheology results suggest that hydrogel characteristics are more suitable for various biomedical applications, such as drug delivery and tissue engineering.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"1 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-05DOI: 10.1515/polyeng-2024-0095
Jinghui Yang
Electromagnetic cooperative strategy has been proved to be an effective approach that can significantly decrease the matching thickness required for reflection loss. However, improving the electromagnetic wave (EMW) absorbing effectiveness with low matching thickness remains challenging for current single-phase absorbing materials. A layer-by-layer construction design is used in our study via a combination with iso-butyl isoprene rubber (IIR) and mixed polyurethane (MPU) as the matrix, with the single-wall carbon nanotubes (SWCNTs) and magnetic powder as fillers. This bilayer composite design resulted in a decrease in matching thickness and a shift in absorption bandwidth to higher frequencies by 40 %–50 %. Furthermore, the trilayer structure of MPU/IIR/MPU was found to stabilize permeability, enhance the thermal stability of the magnetism and improve the shielding effectiveness significantly. The thickness corresponding minimum absorption loss of the trilayer composites decreased and the absorption bandwidth of −10 dB widened by 50 % from 8.2 GHz–9.5 GHz to 10.2 GHz–12.4 GHz.
{"title":"Low thickness electromagnetic wave absorbing polyurethane and IIR composites by interfacial polarization of multi-layer structure","authors":"Jinghui Yang","doi":"10.1515/polyeng-2024-0095","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0095","url":null,"abstract":"Electromagnetic cooperative strategy has been proved to be an effective approach that can significantly decrease the matching thickness required for reflection loss. However, improving the electromagnetic wave (EMW) absorbing effectiveness with low matching thickness remains challenging for current single-phase absorbing materials. A layer-by-layer construction design is used in our study via a combination with iso-butyl isoprene rubber (IIR) and mixed polyurethane (MPU) as the matrix, with the single-wall carbon nanotubes (SWCNTs) and magnetic powder as fillers. This bilayer composite design resulted in a decrease in matching thickness and a shift in absorption bandwidth to higher frequencies by 40 %–50 %. Furthermore, the trilayer structure of MPU/IIR/MPU was found to stabilize permeability, enhance the thermal stability of the magnetism and improve the shielding effectiveness significantly. The thickness corresponding minimum absorption loss of the trilayer composites decreased and the absorption bandwidth of −10 dB widened by 50 % from 8.2 GHz–9.5 GHz to 10.2 GHz–12.4 GHz.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"69 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Globally, the development of porous structured materials has been receiving incredible responses for various high-performance engineering applications. Piezoelectric cellular foams have recently attracted the attention of researchers to emerging applications of acoustic sensors, low-frequency hydrophones, and energy-harvesting devices. As pore morphology is closely related to the shape and the size of the pore-foaming agent, it is necessary to address the influence of particle size of the foaming agent on cell morphology to expand their application area. Hence, this research article establishes the impact of particle size of pore foaming agents on pore morphology, hydrophobicity, and acoustic characteristics of open-cell polyvinylidene fluoride (PVDF) based piezoelectric cellular composites. Open-cell PVDF cellular composites have been fabricated using the template removal method with sodium chloride (NaCl) as a sacrificial templating agent in three different particle sizes: larger, medium, and finer. Based on the experimental results, it can be stated that the particle size of the templating agents dramatically influences the pore morphology, hydrophobicity, and acoustics performance of the PVDF foam samples. The PVDF foams possessing medium pore size have exhibited a maximum sound absorption coefficient of 0.89 at a frequency range of 1,000–1,500 Hz, indicating that PVDF foams have great potential for noise-controlling applications.
{"title":"An experimental investigation on the influence of pore foaming agent particle size on cell morphology, hydrophobicity, and acoustic performance of open cell poly (vinylidene fluoride) polymeric foams","authors":"Nivedhitha Durgam Muralidharan, Jeyanthi Subramanian","doi":"10.1515/polyeng-2024-0124","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0124","url":null,"abstract":"Globally, the development of porous structured materials has been receiving incredible responses for various high-performance engineering applications. Piezoelectric cellular foams have recently attracted the attention of researchers to emerging applications of acoustic sensors, low-frequency hydrophones, and energy-harvesting devices. As pore morphology is closely related to the shape and the size of the pore-foaming agent, it is necessary to address the influence of particle size of the foaming agent on cell morphology to expand their application area. Hence, this research article establishes the impact of particle size of pore foaming agents on pore morphology, hydrophobicity, and acoustic characteristics of open-cell polyvinylidene fluoride (PVDF) based piezoelectric cellular composites. Open-cell PVDF cellular composites have been fabricated using the template removal method with sodium chloride (NaCl) as a sacrificial templating agent in three different particle sizes: larger, medium, and finer. Based on the experimental results, it can be stated that the particle size of the templating agents dramatically influences the pore morphology, hydrophobicity, and acoustics performance of the PVDF foam samples. The PVDF foams possessing medium pore size have exhibited a maximum sound absorption coefficient of 0.89 at a frequency range of 1,000–1,500 Hz, indicating that PVDF foams have great potential for noise-controlling applications.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"2 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-29DOI: 10.1515/polyeng-2024-0109
Ruiying Wu, Meng Chen, Wenjing Zhang, Wenqing Yang, Libin Bai, Li Huo
The reuse of agricultural waste and the development of bio-based materials are the main strategies for solving the global energy crisis and environmental problems. Agricultural waste reeds containing natural nano-silica (SiO2) were liquefied with PEG-400, Castor oil, and acid to produce reed-based polyols (R–P). The result shows that the liquefied product is a polyol with a hydroxyl value of 171 mgKOH/g, a viscosity of 1.221 Pa S, the number average molecular weight (Mn) of 1.202 kg/mol. Then reed-based two-component polyurethane emulsion (R-T-PU) and reed-based one-component waterborne polyurethane emulsion (R-O-WPU) with good glossiness and excellent mechanical properties were prepared. Because of the natural nano-SiO2 in reed and castor oil, the coatings exhibit excellent mechanical properties and hydrophobicity. The results show that the series of reed-based polyurethane has excellent mechanical properties, a maximum hardness of 6H, good hydrophobic effect, a maximum contact angle of 109°, high thermal stability, and a maximum initial decomposition temperature can reach 299.1 °C. Therefore, the environmental protection bio-based polyurethane coating with excellent properties can be prepared with the reed, which is expected to replace fossil resources. It provides an experimental basis for the high-added-value utilization of reed.
{"title":"Synthesis and properties of reed-based polyurethane (PU) coating","authors":"Ruiying Wu, Meng Chen, Wenjing Zhang, Wenqing Yang, Libin Bai, Li Huo","doi":"10.1515/polyeng-2024-0109","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0109","url":null,"abstract":"The reuse of agricultural waste and the development of bio-based materials are the main strategies for solving the global energy crisis and environmental problems. Agricultural waste reeds containing natural nano-silica (SiO<jats:sub>2</jats:sub>) were liquefied with PEG-400, Castor oil, and acid to produce reed-based polyols (R–P). The result shows that the liquefied product is a polyol with a hydroxyl value of 171 mgKOH/g, a viscosity of 1.221 Pa S, the number average molecular weight (Mn) of 1.202 kg/mol. Then reed-based two-component polyurethane emulsion (R-T-PU) and reed-based one-component waterborne polyurethane emulsion (R-O-WPU) with good glossiness and excellent mechanical properties were prepared. Because of the natural nano-SiO<jats:sub>2</jats:sub> in reed and castor oil, the coatings exhibit excellent mechanical properties and hydrophobicity. The results show that the series of reed-based polyurethane has excellent mechanical properties, a maximum hardness of 6H, good hydrophobic effect, a maximum contact angle of 109°, high thermal stability, and a maximum initial decomposition temperature can reach 299.1 °C. Therefore, the environmental protection bio-based polyurethane coating with excellent properties can be prepared with the reed, which is expected to replace fossil resources. It provides an experimental basis for the high-added-value utilization of reed.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"71 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effect of epoxidized soybean oil (ESO) on homocrystallization (HC) and stereocomplex (SC) formation behavior of poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) bends was investigated utilizing differential scanning calorimetry (DSC). Isothermal crystallization was performed on ESO/PLLA/PDLA blends with varying ESO contents (0, 5, 8, and 10 wt%) and temperatures (90 °C, 120 °C, and 150 °C) for a different duration (12.5, 25, and 125 min). It was found that the ESO could effectively inhibit HC crystallization and promote SC crystallization. For the sample without ESO (ESO-0), the isothermal crystallization temperature and duration had little effect on the melting behavior, whereas sample with 5 wt% ESO (ESO-5), HC crystallization decreased while SC crystallization continued to increase with increasing duration. Additionally, at higher crystallization temperatures with constant ESO content, the melting temperature of SC crystals did not significantly change, suggesting that ESO did not degrade PLLA/PDLA blends. These findings imply that ESO modifies crystallization kinetics, suppressing HC formation and enhancing SC formation, which could benefit for specific material properties and applications.
{"title":"Effect of epoxidized soybean oil on melting behavior of poly(l-lactic acid) and poly(d-lactic acid) blends after isothermal crystallization","authors":"Wenwei Li, Jun Shen, Dutchanee Pholharn, Keartisak Sriprateep, Patnarin Worajittiphon, Yottha Srithep","doi":"10.1515/polyeng-2024-0081","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0081","url":null,"abstract":"The effect of epoxidized soybean oil (ESO) on homocrystallization (HC) and stereocomplex (SC) formation behavior of poly(<jats:sc>l</jats:sc>-lactide) (PLLA) and poly(<jats:sc>d</jats:sc>-lactide) (PDLA) bends was investigated utilizing differential scanning calorimetry (DSC). Isothermal crystallization was performed on ESO/PLLA/PDLA blends with varying ESO contents (0, 5, 8, and 10 wt%) and temperatures (90 °C, 120 °C, and 150 °C) for a different duration (12.5, 25, and 125 min). It was found that the ESO could effectively inhibit HC crystallization and promote SC crystallization. For the sample without ESO (ESO-0), the isothermal crystallization temperature and duration had little effect on the melting behavior, whereas sample with 5 wt% ESO (ESO-5), HC crystallization decreased while SC crystallization continued to increase with increasing duration. Additionally, at higher crystallization temperatures with constant ESO content, the melting temperature of SC crystals did not significantly change, suggesting that ESO did not degrade PLLA/PDLA blends. These findings imply that ESO modifies crystallization kinetics, suppressing HC formation and enhancing SC formation, which could benefit for specific material properties and applications.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"49 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1515/polyeng-2024-0104
Christian Hopmann, Jan Wolters
The processing of long glass fibre-reinforced thermoplastics results in considerable fibre damage, particularly during plasticising. By using thermoplastic foam injection moulding (FIM) with a constant blowing agent atmosphere, fibre damage during plasticisation can be reduced. This can be attributed to the reduction of the melt viscosity on the one hand and the influence of the melting behaviour on the other. Therefore, the influence of the FIM and the process parameters on the fibre length and the fibre length distribution are analysed and compared with the influence of the process parameters on the melt viscosity.
长玻璃纤维增强热塑性塑料在加工过程中，尤其是在塑化过程中，会造成严重的纤维损伤。通过使用发泡剂气氛恒定的热塑性泡沫注塑成型（FIM），可减少塑化过程中的纤维损伤。这一方面可归因于熔体粘度的降低，另一方面可归因于熔化行为的影响。因此，我们分析了 FIM 和工艺参数对纤维长度和纤维长度分布的影响，并与工艺参数对熔体粘度的影响进行了比较。
{"title":"Influence of plasticisation during foam injection moulding on the melt viscosity and fibre length of long glass fibre-reinforced polypropylene","authors":"Christian Hopmann, Jan Wolters","doi":"10.1515/polyeng-2024-0104","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0104","url":null,"abstract":"The processing of long glass fibre-reinforced thermoplastics results in considerable fibre damage, particularly during plasticising. By using thermoplastic foam injection moulding (FIM) with a constant blowing agent atmosphere, fibre damage during plasticisation can be reduced. This can be attributed to the reduction of the melt viscosity on the one hand and the influence of the melting behaviour on the other. Therefore, the influence of the FIM and the process parameters on the fibre length and the fibre length distribution are analysed and compared with the influence of the process parameters on the melt viscosity.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"35 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-24DOI: 10.1515/polyeng-2024-0085
Zihao Zhao, Yunyun Xue, Yani Jiang, Qianwei Su, Tong Sun, Wushang Yang, Zelin Qiu, Liheng Zhu, Lifeng Fang, Baoku Zhu
Phase inversion involves in a complex process due to numerous factors affecting the membrane formation. Among them, polymer chain entanglement from polymeric membrane materials plays a critical role in regulating membrane structure and is still worth further exploration. Herein, a series of methacrylate copolymers with different contents of poly(ethylene glycol) methacrylate (PEGMA) were designed and synthesized, and ultrafiltration membranes cast from these copolymers were systematically investigated regarding structural evolution and filtration performance. Surface zeta potential of membranes gradually transformed from positive to negative with the increasing PEGMA content due to nonsolvent-induced surface migration of element oxygen, and meanwhile the transformation from finger-like pore structure to sponge-like pore structure in the support layer was observed, which could be attributed to chain entanglement of the PEGMA-rich copolymer. Filtration experiments indicated that sponge-like membranes possessed better separation effect of Victoria blue B compared with finger-like membranes, and the optimized mPP40-15 % showed a retention rate of 99.55 % and permeance of 110.26 L m−2 h−1 bar−1 and displayed good selective separation of dye/salt mixture. Besides, sponge-like membranes also exhibited easy regeneration, anti-fouling property and filtration stability. This work will provide guidance for modulating membrane structure and offer an alternative material for membrane separation in handling dye wastewater.
由于影响膜形成的因素众多，相位反转是一个复杂的过程。其中，高分子膜材料的聚合物链缠结在调节膜结构方面起着关键作用，仍值得进一步探讨。本文设计合成了一系列不同含量的聚乙二醇甲基丙烯酸酯（PEGMA）共聚物，并系统研究了这些共聚物浇铸的超滤膜的结构演变和过滤性能。随着 PEGMA 含量的增加，膜的表面 zeta 电位逐渐由正变负，这是由于非溶剂引起的氧元素表面迁移所致，同时还观察到支撑层中的指状孔隙结构向海绵状孔隙结构的转变，这可能是由于富含 PEGMA 的共聚物的链缠结所致。过滤实验表明，与指状膜相比，海绵状膜具有更好的维多利亚蓝 B 分离效果，优化后的 mPP40-15 % 的截留率为 99.55 %，渗透率为 110.26 L m-2 h-1 bar-1，对染料/盐混合物具有良好的选择性分离效果。此外，海绵状膜还具有易于再生、防污和过滤稳定的特点。这项工作将为调节膜结构提供指导，并为处理染料废水的膜分离提供一种替代材料。
{"title":"Fabrication of ultrafiltration membranes based on methacrylate copolymers containing quaternary ammonium and PEG units for dye removal","authors":"Zihao Zhao, Yunyun Xue, Yani Jiang, Qianwei Su, Tong Sun, Wushang Yang, Zelin Qiu, Liheng Zhu, Lifeng Fang, Baoku Zhu","doi":"10.1515/polyeng-2024-0085","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0085","url":null,"abstract":"Phase inversion involves in a complex process due to numerous factors affecting the membrane formation. Among them, polymer chain entanglement from polymeric membrane materials plays a critical role in regulating membrane structure and is still worth further exploration. Herein, a series of methacrylate copolymers with different contents of poly(ethylene glycol) methacrylate (PEGMA) were designed and synthesized, and ultrafiltration membranes cast from these copolymers were systematically investigated regarding structural evolution and filtration performance. Surface zeta potential of membranes gradually transformed from positive to negative with the increasing PEGMA content due to nonsolvent-induced surface migration of element oxygen, and meanwhile the transformation from finger-like pore structure to sponge-like pore structure in the support layer was observed, which could be attributed to chain entanglement of the PEGMA-rich copolymer. Filtration experiments indicated that sponge-like membranes possessed better separation effect of Victoria blue B compared with finger-like membranes, and the optimized mPP40-15 % showed a retention rate of 99.55 % and permeance of 110.26 L m<jats:sup>−2</jats:sup> h<jats:sup>−1</jats:sup> bar<jats:sup>−1</jats:sup> and displayed good selective separation of dye/salt mixture. Besides, sponge-like membranes also exhibited easy regeneration, anti-fouling property and filtration stability. This work will provide guidance for modulating membrane structure and offer an alternative material for membrane separation in handling dye wastewater.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"69 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22DOI: 10.1515/polyeng-2024-0094
Bei Ma, Pan Liu, Yaofeng Zhang, Lijun Tang, Zhengyang Zhao, Ze Ding, Tianyang Wang, Tianzhen Dong, Hongwei Chen, Junfeng Liu
When skin comes into direct contact with the outside environment, it becomes extremely prone to injury and external factors can make wounds difficult to heal. Traditional medical dressings often cause secondary injury and are poorly resistant to infection. Hydrogels offer a promising alternative to overcome these difficulties. In this study, chitosan (CS)/gelatin (GEL)/polyvinyl alcohol (PVA) hydrogels were developed by chemical cross-linking and loaded with the drug kitasamycin (KM) for testing. The hydrogels’ in vitro drug release and wound-healing properties were assessed. For 48 h, the drug release from the hydrogel in vitro persisted, which was significantly longer than the release time of the KM solution. Antimicrobial activity tests showed that the loaded KM hydrogel maintained its bacteriostatic ability at the same concentration as the KM solution, and during in vitro bacteriostatic inhibition, the duration of bacteriostatic inhibition of the KM hydrogel was significantly prolonged compared to that of the KM solution. This confirms the controlled release capability of the hydrogel. In addition, the hydrogel reduced the wound size in mice by 96 % and histopathological tests showed complete re-epithelialization of the wound. The prepared hydrogels successfully demonstrated their potential ability to control drug release and promote skin wound healing.
当皮肤与外界环境直接接触时，极易受伤，外部因素也会导致伤口难以愈合。传统的医用敷料往往会造成二次伤害，而且抗感染能力差。水凝胶为克服这些困难提供了一种前景广阔的替代方案。本研究通过化学交联法开发了壳聚糖（CS）/明胶（GEL）/聚乙烯醇（PVA）水凝胶，并在其中添加了药物吉他霉素（KM）进行测试。对水凝胶的体外药物释放和伤口愈合性能进行了评估。水凝胶的体外药物释放持续了 48 小时，明显长于 KM 溶液的释放时间。抗菌活性测试表明，在与 KM 溶液浓度相同的情况下，负载的 KM 水凝胶仍能保持其抑菌能力，而且在体外抑菌过程中，KM 水凝胶的抑菌时间比 KM 溶液的抑菌时间明显延长。这证实了水凝胶的控释能力。此外，水凝胶还使小鼠的伤口面积缩小了 96%，组织病理学测试表明伤口完全重新上皮。制备的水凝胶成功证明了其控制药物释放和促进皮肤伤口愈合的潜在能力。
{"title":"Hydrogel for slow-release drug delivery in wound treatment","authors":"Bei Ma, Pan Liu, Yaofeng Zhang, Lijun Tang, Zhengyang Zhao, Ze Ding, Tianyang Wang, Tianzhen Dong, Hongwei Chen, Junfeng Liu","doi":"10.1515/polyeng-2024-0094","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0094","url":null,"abstract":"When skin comes into direct contact with the outside environment, it becomes extremely prone to injury and external factors can make wounds difficult to heal. Traditional medical dressings often cause secondary injury and are poorly resistant to infection. Hydrogels offer a promising alternative to overcome these difficulties. In this study, chitosan (CS)/gelatin (GEL)/polyvinyl alcohol (PVA) hydrogels were developed by chemical cross-linking and loaded with the drug kitasamycin (KM) for testing. The hydrogels’ <jats:italic>in vitro</jats:italic> drug release and wound-healing properties were assessed. For 48 h, the drug release from the hydrogel <jats:italic>in vitro</jats:italic> persisted, which was significantly longer than the release time of the KM solution. Antimicrobial activity tests showed that the loaded KM hydrogel maintained its bacteriostatic ability at the same concentration as the KM solution, and during <jats:italic>in vitro</jats:italic> bacteriostatic inhibition, the duration of bacteriostatic inhibition of the KM hydrogel was significantly prolonged compared to that of the KM solution. This confirms the controlled release capability of the hydrogel. In addition, the hydrogel reduced the wound size in mice by 96 % and histopathological tests showed complete re-epithelialization of the wound. The prepared hydrogels successfully demonstrated their potential ability to control drug release and promote skin wound healing.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"5 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22DOI: 10.1515/polyeng-2024-0110
Tong Xu, Heyan Peng
The flexibility and sensitivity of traditional sensors is hard to achieve unless wearable technology develops. Flexible piezoresistive sensor (FPS) is one of the solutions in the nondestructive health monitoring of living body. In the application of sensing devices for physiological or biochemical signals, fast feedback speed and accurate signal feedback are essential requirements for obtaining sensitive response signals. Additionally, the development of FPS has promoted the research of conductive materials that could be used in wearable devices. However, improving the performance of functional materials is an important way of effort for researchers. Recently, MXene as a new kind of 2D materials and their composites have made a tremendous impact in the field of sensors for wearable health sensors. Numerous conductive materials based 2D MXene could expedite their practical application in FPS by overcoming the present limitations of FPS such as poor responsivity, signal accuracy, and the narrower corresponding range. There has been plenty of breakthrough in the MXene-based FPS in the past several years. The main purpose of this paper is reviewing the recent development of MXene-based FPS and providing an outlook on the future development of it.
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Antibacterial and oxygen barrier films were inventively prepared by blending very small loadings (<2 wt%) of chitosan oligosaccharide (COS) or chitosan (CS) in thermoplastic starch (TPS) and/or processing with supercritical carbon dioxide (scCO2). Oxygen transmission rates (OTR) and free-volume-hole (FVH) characteristics of scCO2-processed TPS/COS and TPS/CS blown films diminish to a minimum, as their COS or CS approach a specific compatibility limit content. The minimum OTR and FVH characteristics of scCO2-processed TPS/COS films are somewhat smaller than those of corresponding TPS/COS films without scCO2-assistance, and decrease further with decreasing COS molecular weights. The minimum OTR values of scCO2-processed TPS/COS blown films with COS’s molecular weight of 200 and 500 are only 4.1 and 4.5 cm3/m2 × day × atm, respectively, and their antibacterial rates of Staphylococcus aureus are ≥97 %, which make them as promising antibacterial and oxygen barrier films having OTR ≦ 5 cm3/m2 × day × atm. Among other things, longitudinal or transversal tensile strengths acquired for the properly scCO2-processed TPS/COS or TPS/CS films are ∼30 to ∼50 % higher than those of the TPS films. Dynamic mechanical relaxation results of these scCO2-processed reveal that chitosan oligosaccharide or chitosan are compatible with TPS, as COS or CS contents are ≤ the compatibility limit value.
{"title":"ScCO2-processed thermoplastic starch/chitosan oligosaccharide blown films and their oxygen barrier or antibacterial applications","authors":"Zi-yu Wang, Qian-li Luo, Han-fang Mei, Ning Ma, Ya-qiong Huang, Jen-taut Yeh","doi":"10.1515/polyeng-2024-0130","DOIUrl":"https://doi.org/10.1515/polyeng-2024-0130","url":null,"abstract":"Antibacterial and oxygen barrier films were inventively prepared by blending very small loadings (<2 wt%) of chitosan oligosaccharide (COS) or chitosan (CS) in thermoplastic starch (TPS) and/or processing with supercritical carbon dioxide (scCO<jats:sub>2</jats:sub>). Oxygen transmission rates (OTR) and free-volume-hole (FVH) characteristics of scCO<jats:sub>2-</jats:sub>processed TPS/COS and TPS/CS blown films diminish to a minimum, as their COS or CS approach a specific compatibility limit content. The minimum OTR and FVH characteristics of scCO<jats:sub>2</jats:sub>-processed TPS/COS films are somewhat smaller than those of corresponding TPS/COS films without scCO<jats:sub>2</jats:sub>-assistance, and decrease further with decreasing COS molecular weights. The minimum OTR values of scCO<jats:sub>2</jats:sub>-processed TPS/COS blown films with COS’s molecular weight of 200 and 500 are only 4.1 and 4.5 cm<jats:sup>3</jats:sup>/m<jats:sup>2 </jats:sup>× day × atm, respectively, and their antibacterial rates of <jats:italic>Staphylococcus aureus</jats:italic> are ≥97 %, which make them as promising antibacterial and oxygen barrier films having OTR ≦ 5 cm<jats:sup>3</jats:sup>/m<jats:sup>2 </jats:sup>× day × atm. Among other things, longitudinal or transversal tensile strengths acquired for the properly scCO<jats:sub>2</jats:sub>-processed TPS/COS or TPS/CS films are ∼30 to ∼50 % higher than those of the TPS films. Dynamic mechanical relaxation results of these scCO<jats:sub>2-</jats:sub>processed reveal that chitosan oligosaccharide or chitosan are compatible with TPS, as COS or CS contents are ≤ the compatibility limit value.","PeriodicalId":16881,"journal":{"name":"Journal of Polymer Engineering","volume":"24 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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