S. Rather, M. Banday, S. Wani, Aijaz A. Khan, M. Shah, T. Tali, F. Mir, M. A. Badhul Haq
{"title":"Study on Dosimetric Superiority of Forward Planned Intensity-Modulated Radiotherapy Treatment of Thoracic Esophageal Squamous Cell Carcinoma","authors":"S. Rather, M. Banday, S. Wani, Aijaz A. Khan, M. Shah, T. Tali, F. Mir, M. A. Badhul Haq","doi":"10.4103/jrcr.jrcr_71_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_71_22","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75750087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rather, M. Banday, Samina Mufti, MustaqAhmad Sofi, MisbhaHamid Baba
{"title":"Analysis of Different Evaluation Indexes for Postoperative Brain Cancer Radiation Therapy Plans: Conformity Index, Homogeneity Index, and Total Coverage Index","authors":"S. Rather, M. Banday, Samina Mufti, MustaqAhmad Sofi, MisbhaHamid Baba","doi":"10.4103/jrcr.jrcr_91_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_91_22","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79759291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saimul Islam, Mukta Basu, A. Roy, N. Alam, C. Panda
Purpose: The aim of the study is to understand the involvement of G-Quadruplex (G-Q) structures in altering the expression profile of WNT/epidermal growth factor receptor (EGFR) pathway receptor genes in chemo-tolerant Triple Negative Breast Cancer (TNBC) samples. Materials and Methods: At first, Gene Expression Omnibus datasets were mined where the expression profile of WNT/EGFR pathway genes in TNBC samples and MDA-MB-231, a TNBC cell line, were checked in response to doxorubicin, a chemotherapeutic drug. Next, to unveil the probable mechanism of regulation, the presence of G-Q structure was checked in in silico study and later validated by immunohistochemical analyses in our pool of sample. These observed results were correlated with patient's demography and survival status. Results: Expression of the receptors (FZD7, LRP6, EGFR) of the WNT/EGFR pathway were found to be differentially expressed in TNBC samples; further emphasized in our samples (n = 61). Notably, these G-Q structures were found in the promoter region of the WNT pathway receptor genes (FZD7, LRP6, and EGFR). Validating in our patient sample pool, a significant increase in G-Q immunostaining was observed in samples, after neoadjuvant chemotherapy (NACT) samples (n = 17) than the pretherapeutic samples (n = 44). Similar pattern of G-Q immunostaining was noticed in doxorubicin-treated MDA-MB-231 cell line. Intriguingly, low staining of G-Q among the pretherapeutic samples, but NACT TNBC samples, was found to be significantly correlated with lymph node metastasis. Conclusions: This study showed that the augmented immunostaining of G-Q structure might have an important involvement in regulating the expression pattern of the WNT/EGFR pathway genes in response to doxorubicin treatment of TNBC.
{"title":"Association of Augmented Immune-Staining of G-Quadruplex Tertiary DNA Structure in Chemo-Tolerant TNBC with Downregulation of WNT/Epidermal Growth Factor Receptor Pathway receptor Genes: A Pilot Clinicopathological Study","authors":"Saimul Islam, Mukta Basu, A. Roy, N. Alam, C. Panda","doi":"10.4103/jrcr.jrcr_23_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_23_22","url":null,"abstract":"Purpose: The aim of the study is to understand the involvement of G-Quadruplex (G-Q) structures in altering the expression profile of WNT/epidermal growth factor receptor (EGFR) pathway receptor genes in chemo-tolerant Triple Negative Breast Cancer (TNBC) samples. Materials and Methods: At first, Gene Expression Omnibus datasets were mined where the expression profile of WNT/EGFR pathway genes in TNBC samples and MDA-MB-231, a TNBC cell line, were checked in response to doxorubicin, a chemotherapeutic drug. Next, to unveil the probable mechanism of regulation, the presence of G-Q structure was checked in in silico study and later validated by immunohistochemical analyses in our pool of sample. These observed results were correlated with patient's demography and survival status. Results: Expression of the receptors (FZD7, LRP6, EGFR) of the WNT/EGFR pathway were found to be differentially expressed in TNBC samples; further emphasized in our samples (n = 61). Notably, these G-Q structures were found in the promoter region of the WNT pathway receptor genes (FZD7, LRP6, and EGFR). Validating in our patient sample pool, a significant increase in G-Q immunostaining was observed in samples, after neoadjuvant chemotherapy (NACT) samples (n = 17) than the pretherapeutic samples (n = 44). Similar pattern of G-Q immunostaining was noticed in doxorubicin-treated MDA-MB-231 cell line. Intriguingly, low staining of G-Q among the pretherapeutic samples, but NACT TNBC samples, was found to be significantly correlated with lymph node metastasis. Conclusions: This study showed that the augmented immunostaining of G-Q structure might have an important involvement in regulating the expression pattern of the WNT/EGFR pathway genes in response to doxorubicin treatment of TNBC.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78607597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Remembering Dr. Bam Bahadur Singh: An outstanding Scientist and a learned lawyer","authors":"KP Mishra","doi":"10.4103/jrcr.jrcr_9_23","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_9_23","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82615987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An observational study of diffusion-wssseighted imaging characteristics in patients with cervical cancer","authors":"Hitesh Sinduriyan, Rachit Sharma, GauravPratap Singh Gahlot","doi":"10.4103/jrcr.jrcr_22_23","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_22_23","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76742950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Dar, T. Tali, Fiza Amin, NazirAhmad Khan, N. Dar
{"title":"Significance of physical activity and exercise in cancer patients: A review on exercise oncology","authors":"J. Dar, T. Tali, Fiza Amin, NazirAhmad Khan, N. Dar","doi":"10.4103/jrcr.jrcr_57_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_57_22","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79739261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sujata Sarkar, I. Bashir, R. Yotham, Ritesh Sharma
Extramedullary plasmacytomas (EMPs) are solitary plasma cell neoplasms that involve sites other than bone or bone marrow. It constitutes only 0.4% of tumors of head-and-neck region. Surgery and radiotherapy are standard treatment, depending on the site. Radiotherapy promises 90–100% local control rate and prolonged survival. Here, we are reporting a case of plasmacytoma nasopharynx treated with volumetric-modulated arc technique (VMAT) radiotherapy, with contouring details, dose to target, and nearby structures. Patient had complete response and is relapse free for the past 3 years with minimal toxicity. In our case, the lesion is in nasopharynx and is about 1cm, as such it required precise radiotherapy technique like VMAT, to give targeted dose delivery and sparing the nearby critical organs.
{"title":"Plasmacytoma of nasopharynx - A rare case presentation treated with volumetric modulated arc technique radiotherapy","authors":"Sujata Sarkar, I. Bashir, R. Yotham, Ritesh Sharma","doi":"10.4103/jrcr.jrcr_6_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_6_22","url":null,"abstract":"Extramedullary plasmacytomas (EMPs) are solitary plasma cell neoplasms that involve sites other than bone or bone marrow. It constitutes only 0.4% of tumors of head-and-neck region. Surgery and radiotherapy are standard treatment, depending on the site. Radiotherapy promises 90–100% local control rate and prolonged survival. Here, we are reporting a case of plasmacytoma nasopharynx treated with volumetric-modulated arc technique (VMAT) radiotherapy, with contouring details, dose to target, and nearby structures. Patient had complete response and is relapse free for the past 3 years with minimal toxicity. In our case, the lesion is in nasopharynx and is about 1cm, as such it required precise radiotherapy technique like VMAT, to give targeted dose delivery and sparing the nearby critical organs.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74965428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Nath, M. Bhattacharyya, Saswati Datta, Shiraj Ahmed, J. Das, Yanpothung Yanthan
{"title":"Synchronous squamous cell carcinoma of the hypopharynx and adenocarcinoma of the lung: A report of two cases treated with definitive radiotherapy","authors":"J. Nath, M. Bhattacharyya, Saswati Datta, Shiraj Ahmed, J. Das, Yanpothung Yanthan","doi":"10.4103/jrcr.jrcr_13_23","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_13_23","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89835568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Excitements in radiobiology","authors":"KP Mishra","doi":"10.4103/jrcr.jrcr_76_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_76_22","url":null,"abstract":"","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90877414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lung cancer is largely classified into two types according to its histology, small cell and nonsmall cell, and has diverse situations for which radiotherapy is indicated. Radiation therapy plays a major role in the treatment strategy for both types of lung cancer. Since the treatment of lung cancer is extremely complex, it is essential to develop an appropriate treatment strategy by combining surgery, radiotherapy, and systemic therapy (chemotherapy, immunotherapy, and molecular-targeted drugs) according to each stage of the disease. Radiotherapy is indicated, from curative intent to palliative treatment, at any stage of the disease. Current radiotherapy, which incorporates diagnostic imaging and physical engineering, has made significant progress, making it possible to increase the local control rate while reducing the radiation dose to at-risk organs. Herein, we review the basics of the current perspective of radiotherapy and the current role of radiotherapy in lung cancer treatment according to each stage of the disease.
{"title":"Changing treatment paradigms of radiotherapy for the treatment of lung cancer","authors":"Atsuto Katano","doi":"10.4103/jrcr.jrcr_5_22","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_5_22","url":null,"abstract":"Lung cancer is largely classified into two types according to its histology, small cell and nonsmall cell, and has diverse situations for which radiotherapy is indicated. Radiation therapy plays a major role in the treatment strategy for both types of lung cancer. Since the treatment of lung cancer is extremely complex, it is essential to develop an appropriate treatment strategy by combining surgery, radiotherapy, and systemic therapy (chemotherapy, immunotherapy, and molecular-targeted drugs) according to each stage of the disease. Radiotherapy is indicated, from curative intent to palliative treatment, at any stage of the disease. Current radiotherapy, which incorporates diagnostic imaging and physical engineering, has made significant progress, making it possible to increase the local control rate while reducing the radiation dose to at-risk organs. Herein, we review the basics of the current perspective of radiotherapy and the current role of radiotherapy in lung cancer treatment according to each stage of the disease.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87867334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：