Saeed Mardani, Shadi Nilieh, M. Amiri, B. Sadeghi, M. Momenzadeh, Sara Nasirharandi
Introduction: Chronic inflammation is one of the underlying causes of cardiovascular disease which is commonly seen in patients with chronic kidney disease (CKD) and especially in end-stage renal disease (ESRD), as well as the patients on stable dialysis. Hemodialysis patients suffer from high mortality due to cardiovascular diseases. Objectives: Therefore, the present study aimed to evaluate the effect of atorvastatin and aspirin on C-reactive protein (CRP) concentration in hemodialysis patients and compare the effect of these two drugs on CRP concentration in these patients. Patients and Methods: In this descriptive-analytical study, the dialysis patients who had been on dialysis for more than four months were selected through medical records (N=75). Serum CRP was checked and those who had positive CRP entered in the analysis (n=20). Ten patients had been used atorvastatin at a dose of 20 mg daily and the other 10 patients received aspirin at a dose of 80 mg daily for two months. Serum CRP concentration was measured in all patients at the end of these two months. Results: The mean age of the patients was 65.6 years and the mean number of years on dialysis was three years. In addition, 65% of patients were male and 35% were female. The only significant relationship was between the effect of atorvastatin and CRP concentration and the effect of aspirin on CRP concentration while no statistically significant relationship was found between the two groups of aspirin and atorvastatin in terms of serum CRP value after the intervention. Conclusion: The results indicated that the effect of aspirin and atorvastatin on CRP concentration was positive in hemodialysis patients and reduced the serum level of CRP, indicating the anti-inflammatory role of these two drugs in hemodialysis patients. It should be noted that drug preference was not determined in the present study.
{"title":"Comparison of the effect of atorvastatin and aspirin on C-reactive protein concentration in hemodialysis patients","authors":"Saeed Mardani, Shadi Nilieh, M. Amiri, B. Sadeghi, M. Momenzadeh, Sara Nasirharandi","doi":"10.34172/jre.2023.17070","DOIUrl":"https://doi.org/10.34172/jre.2023.17070","url":null,"abstract":"Introduction: Chronic inflammation is one of the underlying causes of cardiovascular disease which is commonly seen in patients with chronic kidney disease (CKD) and especially in end-stage renal disease (ESRD), as well as the patients on stable dialysis. Hemodialysis patients suffer from high mortality due to cardiovascular diseases. Objectives: Therefore, the present study aimed to evaluate the effect of atorvastatin and aspirin on C-reactive protein (CRP) concentration in hemodialysis patients and compare the effect of these two drugs on CRP concentration in these patients. Patients and Methods: In this descriptive-analytical study, the dialysis patients who had been on dialysis for more than four months were selected through medical records (N=75). Serum CRP was checked and those who had positive CRP entered in the analysis (n=20). Ten patients had been used atorvastatin at a dose of 20 mg daily and the other 10 patients received aspirin at a dose of 80 mg daily for two months. Serum CRP concentration was measured in all patients at the end of these two months. Results: The mean age of the patients was 65.6 years and the mean number of years on dialysis was three years. In addition, 65% of patients were male and 35% were female. The only significant relationship was between the effect of atorvastatin and CRP concentration and the effect of aspirin on CRP concentration while no statistically significant relationship was found between the two groups of aspirin and atorvastatin in terms of serum CRP value after the intervention. Conclusion: The results indicated that the effect of aspirin and atorvastatin on CRP concentration was positive in hemodialysis patients and reduced the serum level of CRP, indicating the anti-inflammatory role of these two drugs in hemodialysis patients. It should be noted that drug preference was not determined in the present study.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"82 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77904309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hekmat, H. Ghaderi, Zahra Ansari Aval, S. Mirjafari, Mandana Hekmat, R. Tirdad
Open heart surgeries are inevitable during pandemic and there is the possibility of corona virus transmission through oxygenated exhaust during cardiopulmonary bypass (CBP). In this study, researchers try to test the hypothesis by placing an antiviral and antibacterial filter in the air outlet of the oxygenator in order to prevent spread of COVID-19 virus in operating room. The COVID-19 positive patient needed emergency open-heart surgery due to her critical situation. The patient was under cardiopulmonary bypass for almost two hours. Antibacterial and antiviral filters were placed in oxygenator outlet. At the end of the procedure, polymerase chain reaction (PCR) swab was taken from both sides of the filter. The result of the test behind the filter was positive, but at the other side of the filter was negative. This may suggest, the exhaust air from the oxygenator can spread viruses into the room and the antibacterial and antiviral filters may be able to prevent operating room contamination. The installation of filter in the oxygenator exhaust can prevent the spread of COVID-19 viruses into the operating room air. Using this cheap and affordable method, operating room staff safety can be assured.
{"title":"Do antibacterial or antiviral filters protect operating room staff by preventing COVID-19 virus spread from cardiopulmonary bypass machine during open hear surgeries? A case report","authors":"M. Hekmat, H. Ghaderi, Zahra Ansari Aval, S. Mirjafari, Mandana Hekmat, R. Tirdad","doi":"10.34172/jre.2023.20062","DOIUrl":"https://doi.org/10.34172/jre.2023.20062","url":null,"abstract":"Open heart surgeries are inevitable during pandemic and there is the possibility of corona virus transmission through oxygenated exhaust during cardiopulmonary bypass (CBP). In this study, researchers try to test the hypothesis by placing an antiviral and antibacterial filter in the air outlet of the oxygenator in order to prevent spread of COVID-19 virus in operating room. The COVID-19 positive patient needed emergency open-heart surgery due to her critical situation. The patient was under cardiopulmonary bypass for almost two hours. Antibacterial and antiviral filters were placed in oxygenator outlet. At the end of the procedure, polymerase chain reaction (PCR) swab was taken from both sides of the filter. The result of the test behind the filter was positive, but at the other side of the filter was negative. This may suggest, the exhaust air from the oxygenator can spread viruses into the room and the antibacterial and antiviral filters may be able to prevent operating room contamination. The installation of filter in the oxygenator exhaust can prevent the spread of COVID-19 viruses into the operating room air. Using this cheap and affordable method, operating room staff safety can be assured.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72732906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Koratala, N. C. Chandra, Yassamin Rabiei, Z. Rezvani, Sina Neshat
Three different formations of Aloe vera are frequently used in therapeutic applications, which are completely diverse in their biochemical content and beneficial characteristics, latex, gel, and extract. Recently, investigators have employed Aloe vera with new decomposable efficient biomaterials and nanostructures for targeting applications like tissue engineering, drug delivery systems, the remedy of various diseases, the food industry, and the removal of pollutants. Numerous different nanostructures made by Aloe vera for different applications are presented in this review.
{"title":"Aloe vera applications and Aloe vera based nanomaterials","authors":"A. Koratala, N. C. Chandra, Yassamin Rabiei, Z. Rezvani, Sina Neshat","doi":"10.34172/jre.2023.22063","DOIUrl":"https://doi.org/10.34172/jre.2023.22063","url":null,"abstract":"Three different formations of Aloe vera are frequently used in therapeutic applications, which are completely diverse in their biochemical content and beneficial characteristics, latex, gel, and extract. Recently, investigators have employed Aloe vera with new decomposable efficient biomaterials and nanostructures for targeting applications like tissue engineering, drug delivery systems, the remedy of various diseases, the food industry, and the removal of pollutants. Numerous different nanostructures made by Aloe vera for different applications are presented in this review.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"231 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78291881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leyla Mahmoudnia, Farzad Abkhou, A. Bazdar, F. Ganji, M. Momenzadeh
Introduction: Radiocontrast nephrotoxicity refers to one of the most prevalent and key complications in diabetic patients. Objectives: This study was aimed to investigate the therapeutic and protective effect of lycopene on contrast-induced nephrotoxicity (CIN) in diabetic patients undergoing coronary angiography. Patients and Methods: In this study, 113 patients who took lycopene with prevention of contrast induced kidney injury regime (lycopene group) or prevention of kidney injury regimen alone (regimen group) were investigated through medical records. Oral lycopene was administered 24 hours before to 72 hours after the angiography. Blood urea nitrogen (BUN), creatinine (Cr), and glomerular filtration rate (GFR) were assessed and recorded in a checklist. SPSS software was conducted for data analysis. Results: At the baseline, there was no significant difference between the mean of urea, Cr, and GFR (P>0.05). However, after administration of lycopene, a significant difference between the mean BUN was observed among groups (P<0.001), with lower rate in the patients taking oral lycopene. Although the mean Cr decreased after the administration of oral lycopene, no statistically significant difference was seen (P = 0.08). The mean GFR was not significant different between the two groups of regimen and lycopene (P=0.44). Conclusion: In patients with diabetes, taking lycopene for CIN may help improve some biochemical factors; nevertheless, its positive effect on the improvement of nephrotoxicity indices cannot be certainly determined.
{"title":"The effect of lycopene on contrast-induced nephrotoxicity in diabetic patients undergoing coronary angiography","authors":"Leyla Mahmoudnia, Farzad Abkhou, A. Bazdar, F. Ganji, M. Momenzadeh","doi":"10.34172/jre.2023.17073","DOIUrl":"https://doi.org/10.34172/jre.2023.17073","url":null,"abstract":"Introduction: Radiocontrast nephrotoxicity refers to one of the most prevalent and key complications in diabetic patients. Objectives: This study was aimed to investigate the therapeutic and protective effect of lycopene on contrast-induced nephrotoxicity (CIN) in diabetic patients undergoing coronary angiography. Patients and Methods: In this study, 113 patients who took lycopene with prevention of contrast induced kidney injury regime (lycopene group) or prevention of kidney injury regimen alone (regimen group) were investigated through medical records. Oral lycopene was administered 24 hours before to 72 hours after the angiography. Blood urea nitrogen (BUN), creatinine (Cr), and glomerular filtration rate (GFR) were assessed and recorded in a checklist. SPSS software was conducted for data analysis. Results: At the baseline, there was no significant difference between the mean of urea, Cr, and GFR (P>0.05). However, after administration of lycopene, a significant difference between the mean BUN was observed among groups (P<0.001), with lower rate in the patients taking oral lycopene. Although the mean Cr decreased after the administration of oral lycopene, no statistically significant difference was seen (P = 0.08). The mean GFR was not significant different between the two groups of regimen and lycopene (P=0.44). Conclusion: In patients with diabetes, taking lycopene for CIN may help improve some biochemical factors; nevertheless, its positive effect on the improvement of nephrotoxicity indices cannot be certainly determined.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88245838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parisa Soleimani, Sepideh Yadollahifarsani, Elnaz Marzbani, H. Jahantigh
Monkeypox is a common disease between humans and animals. The cause of this disease is a member of the Poxviridae family. The transmission of this disease is mostly through aerosol, direct contact and insect bites. Monkeypox has different symptoms; its skin lesions are papules then; they progress toward vesicles and finally create classic pock lesions. The duration of lesions are 4 to 14 days and they are usually seen on hands, feet and face. This disease can cause fever, lymphadenopathy, encephalitis and keratitis. Thus, monkeypox in the course of its development involves several organs. Due to the limited number of studies conducted on this virus, we designed this study to investigate signs, symptoms and effect of monkeypox virus on kidneys and compare with other similar viruses such as other genera of Orthopoxvirus and varicella-zoster.
{"title":"A nephrology viewpoint on human monkeypox; a mini-review to current knowledge and new concepts","authors":"Parisa Soleimani, Sepideh Yadollahifarsani, Elnaz Marzbani, H. Jahantigh","doi":"10.34172/jre.2023.22062","DOIUrl":"https://doi.org/10.34172/jre.2023.22062","url":null,"abstract":"Monkeypox is a common disease between humans and animals. The cause of this disease is a member of the Poxviridae family. The transmission of this disease is mostly through aerosol, direct contact and insect bites. Monkeypox has different symptoms; its skin lesions are papules then; they progress toward vesicles and finally create classic pock lesions. The duration of lesions are 4 to 14 days and they are usually seen on hands, feet and face. This disease can cause fever, lymphadenopathy, encephalitis and keratitis. Thus, monkeypox in the course of its development involves several organs. Due to the limited number of studies conducted on this virus, we designed this study to investigate signs, symptoms and effect of monkeypox virus on kidneys and compare with other similar viruses such as other genera of Orthopoxvirus and varicella-zoster.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81332190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elnaz Marzbani, R. Valizadeh, N. Tavassoli, H. Nasri, Yassamin Rabiei
This is a cross-sectional investigation, which was carried out on 127 kidney biopsy proven lupus nephritis cases by lupus nephritis classification of ISN/RPS 2003. We studied demographic data of all individuals comprising serum creatinine, 24 hours proteinuria, age and gender. Our study showed no difference of serum creatinine and 24 hours proteinuria and lupus nephritis (LN) classes between age below or equal to 40 versus more than 40 years old. In this study also, we found no significant difference of antibody deposited intensity of IgG, C3 and C1q in immunofluorescence study in age below or equal to 40 versus more than 40 years old. Accordingly, no significant difference of LN classes, activity or chronicity percent between ages below or equal to 40 versus more than 40 years old. Moreover, no significant difference of number of sclerotic glomeruli or crescents among patients with ages below or equal to 40 versus more than 40 years old were detected.
{"title":"Lack of differences between morphological variables in age below 40 years versus more than 40 years in lupus nephritis patients","authors":"Elnaz Marzbani, R. Valizadeh, N. Tavassoli, H. Nasri, Yassamin Rabiei","doi":"10.34172/jre.2023.18062","DOIUrl":"https://doi.org/10.34172/jre.2023.18062","url":null,"abstract":"This is a cross-sectional investigation, which was carried out on 127 kidney biopsy proven lupus nephritis cases by lupus nephritis classification of ISN/RPS 2003. We studied demographic data of all individuals comprising serum creatinine, 24 hours proteinuria, age and gender. Our study showed no difference of serum creatinine and 24 hours proteinuria and lupus nephritis (LN) classes between age below or equal to 40 versus more than 40 years old. In this study also, we found no significant difference of antibody deposited intensity of IgG, C3 and C1q in immunofluorescence study in age below or equal to 40 versus more than 40 years old. Accordingly, no significant difference of LN classes, activity or chronicity percent between ages below or equal to 40 versus more than 40 years old. Moreover, no significant difference of number of sclerotic glomeruli or crescents among patients with ages below or equal to 40 versus more than 40 years old were detected.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74131178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Prevalence of obesity can predispose children to development of fatty liver disease which, given the asymptomatic nature of this disease, may turn into cirrhosis at the end of adolescence if it is not treated. Objectives: This study aimed to compare overweight and obese children with normal weight ones in terms of prevalence of fatty liver disease. Patients and Methods: This cross-sectional study was conducted from 2019 to 2020. A total of 952 children in the 6-18 years age group admitted to the Children medical and training center (Tabriz University of Medical Sciences) were enrolled using multistage cluster random sampling. The participants included 408 normal weight, 314 overweight, and 230 obese children. Chi-square and ANOVA tests were performed to compare the demographic information, anthropometric indices, and liver ultrasound results of the members in the three groups. P value less than 0.05 was considered significant. Results: The prevalence rate of fatty liver disease in all participants was 16.91%, whereas that in the overweight and obese children was 29.59%. The results suggested that the prevalence of fatty liver was increasing in normal weight, overweight, and obese children. Conclusion: Overweight and obesity in children led to the development of fatty liver. Preventive measures must be taken because one third of the studied obese and overweight children developed fatty liver disease.
{"title":"Comparison of fatty liver disease development in overweight, obese and normal weight children","authors":"L. Saboktakin","doi":"10.34172/jre.2022.17068","DOIUrl":"https://doi.org/10.34172/jre.2022.17068","url":null,"abstract":"Introduction: Prevalence of obesity can predispose children to development of fatty liver disease which, given the asymptomatic nature of this disease, may turn into cirrhosis at the end of adolescence if it is not treated. Objectives: This study aimed to compare overweight and obese children with normal weight ones in terms of prevalence of fatty liver disease. Patients and Methods: This cross-sectional study was conducted from 2019 to 2020. A total of 952 children in the 6-18 years age group admitted to the Children medical and training center (Tabriz University of Medical Sciences) were enrolled using multistage cluster random sampling. The participants included 408 normal weight, 314 overweight, and 230 obese children. Chi-square and ANOVA tests were performed to compare the demographic information, anthropometric indices, and liver ultrasound results of the members in the three groups. P value less than 0.05 was considered significant. Results: The prevalence rate of fatty liver disease in all participants was 16.91%, whereas that in the overweight and obese children was 29.59%. The results suggested that the prevalence of fatty liver was increasing in normal weight, overweight, and obese children. Conclusion: Overweight and obesity in children led to the development of fatty liver. Preventive measures must be taken because one third of the studied obese and overweight children developed fatty liver disease.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77039320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lillian Saberian, Niloufar Alimohammadi, Farzad Koosha, Hedayat Vali Rahvard, K. Ahmadi, H. Jahantigh, Tella Sadighpour
Curcumin is the essential ingredient of turmeric and one of the most potent antioxidants. It also has several biological capabilities, including anti-inflammatory, anticarcinogenic, anticoagulant, antidiabetic, antiviral, antibacterial, and antifungal effects. Therefore, curcumin has a significant potential for the treatment and control of various diseases. In kidney disorders like chronic kidney disease (CKD) and diabetic nephropathy (DN), the mechanism of kidney damage is associated with oxidative stress and inflammation. Curcumin, which has antioxidant and anti-inflammatory abilities, can alleviate kidney damage and treat kidney diseases. In patients with kidney disorders, progression to end-stage renal disease (ESRD) is critical because it increases their mortality rate. It has also been proved that curcumin could diminish such progression due to its antioxidant and anti-inflammatory potential, improving the survival rate. Besides, it has numerous nephroprotective effects that are summarized in this review.
{"title":"Therapeutic effects of curcumin on kidney disease; an updated review of the current knowledge","authors":"Lillian Saberian, Niloufar Alimohammadi, Farzad Koosha, Hedayat Vali Rahvard, K. Ahmadi, H. Jahantigh, Tella Sadighpour","doi":"10.34172/jre.2022.23063","DOIUrl":"https://doi.org/10.34172/jre.2022.23063","url":null,"abstract":"Curcumin is the essential ingredient of turmeric and one of the most potent antioxidants. It also has several biological capabilities, including anti-inflammatory, anticarcinogenic, anticoagulant, antidiabetic, antiviral, antibacterial, and antifungal effects. Therefore, curcumin has a significant potential for the treatment and control of various diseases. In kidney disorders like chronic kidney disease (CKD) and diabetic nephropathy (DN), the mechanism of kidney damage is associated with oxidative stress and inflammation. Curcumin, which has antioxidant and anti-inflammatory abilities, can alleviate kidney damage and treat kidney diseases. In patients with kidney disorders, progression to end-stage renal disease (ESRD) is critical because it increases their mortality rate. It has also been proved that curcumin could diminish such progression due to its antioxidant and anti-inflammatory potential, improving the survival rate. Besides, it has numerous nephroprotective effects that are summarized in this review.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85403709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colchicine as an old drug and is usually the first choice of treatment for acute gout to reduce pain and inflammation. Colchicine seems to prevent various pro-inflammatory mechanisms, whereas it allows increasing concentration of anti-inflammatory molecules, which leads to clinical advantage in patients with gout. Colchicine is using generally as a treatment for acute gout however, it has also newly been revealed to have anti-fibrotic effects in different kinds of nephropathies such as polycystic kidney disease, diabetic nephropathy and amyloidosis. Extended use of colchicine is associated with nephrotoxicity depending on its dose, which results to impairment of renal function. Risk of colchicine therapy is accentuated in chronic kidney disease (CKD) patients; therefore, dose reduction is necessary dependent on CKD stage.
{"title":"Colchicine and the concepts of nephroprotection; a new feature of an old drug","authors":"H. Nasri","doi":"10.34172/jre.2022.25072","DOIUrl":"https://doi.org/10.34172/jre.2022.25072","url":null,"abstract":"Colchicine as an old drug and is usually the first choice of treatment for acute gout to reduce pain and inflammation. Colchicine seems to prevent various pro-inflammatory mechanisms, whereas it allows increasing concentration of anti-inflammatory molecules, which leads to clinical advantage in patients with gout. Colchicine is using generally as a treatment for acute gout however, it has also newly been revealed to have anti-fibrotic effects in different kinds of nephropathies such as polycystic kidney disease, diabetic nephropathy and amyloidosis. Extended use of colchicine is associated with nephrotoxicity depending on its dose, which results to impairment of renal function. Risk of colchicine therapy is accentuated in chronic kidney disease (CKD) patients; therefore, dose reduction is necessary dependent on CKD stage.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"240 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78514307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Many studies over the last two decades have dealt with the comorbidity of chronic liver disease (CLD) and endocrine disorders. Nevertheless, regional differences can affect the prevalence and etiology of diseases and their complications. Objectives: Since no similar study has been conducted in Tabriz (a populous city in Iran), this study aimed to address the comorbidity of hormonal disorders in children with CLD visiting Children’s hospital of Tabriz (a center in northwest Iran). Patients and Methods: This descriptive cross-sectional study was conducted on children (2-18 years old) with CLD who visited Children’s hospital of Tabriz in 2019-2020. Of them, 60 children were randomly selected as the sample. First, the status of endocrines was examined, and then its association with CLD was determined. Results: The mean Insulin-like growth factor (IGF 1) of participants in all age groups was lower than the standard range. There was no significant difference between participants with different endocrine disorders in the levels of calcium, phosphorus, albumin, parathyroid hormone (PTH), total protein, cholesterol, triglyceride, growth hormone, and fasting blood sugar as well as the results of thyroid function tests. However, there was a significant difference between participants with different types of endocrine disorders in terms of IGF 1 (P=0.018). The highest and the lowest mean values of IGF 1 were observed in patients with primary sclerosing cholangitis (PSC) (520.59±12.52 ng/dL) and patients with primary biliary cirrhosis (142.95±3.96 ng/dL), respectively. Conclusion: Autoimmune hepatitis was the most common chronic disease among the participants of this study. CLD causes a decrease in IGF1 level and it is responsible for about one-third of all bone fractures; however, overt diabetes and thyroid diseases were not observed in these patients.
{"title":"Comorbidity of endocrine disorders in children with chronic liver disease visiting Children’s hospital of Tabriz University of Medical Sciences","authors":"L. Saboktakin","doi":"10.34172/jre.2022.17067","DOIUrl":"https://doi.org/10.34172/jre.2022.17067","url":null,"abstract":"Introduction: Many studies over the last two decades have dealt with the comorbidity of chronic liver disease (CLD) and endocrine disorders. Nevertheless, regional differences can affect the prevalence and etiology of diseases and their complications. Objectives: Since no similar study has been conducted in Tabriz (a populous city in Iran), this study aimed to address the comorbidity of hormonal disorders in children with CLD visiting Children’s hospital of Tabriz (a center in northwest Iran). Patients and Methods: This descriptive cross-sectional study was conducted on children (2-18 years old) with CLD who visited Children’s hospital of Tabriz in 2019-2020. Of them, 60 children were randomly selected as the sample. First, the status of endocrines was examined, and then its association with CLD was determined. Results: The mean Insulin-like growth factor (IGF 1) of participants in all age groups was lower than the standard range. There was no significant difference between participants with different endocrine disorders in the levels of calcium, phosphorus, albumin, parathyroid hormone (PTH), total protein, cholesterol, triglyceride, growth hormone, and fasting blood sugar as well as the results of thyroid function tests. However, there was a significant difference between participants with different types of endocrine disorders in terms of IGF 1 (P=0.018). The highest and the lowest mean values of IGF 1 were observed in patients with primary sclerosing cholangitis (PSC) (520.59±12.52 ng/dL) and patients with primary biliary cirrhosis (142.95±3.96 ng/dL), respectively. Conclusion: Autoimmune hepatitis was the most common chronic disease among the participants of this study. CLD causes a decrease in IGF1 level and it is responsible for about one-third of all bone fractures; however, overt diabetes and thyroid diseases were not observed in these patients.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"218 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73147576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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