Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2019.81666
Maciej Składanowski, P. Jarosz, B. Maćkiewicz
Introduction: Peak expiratory flow (PEF), a measure of lung function, was first described by Hadorn in 1942. The definition of PEF, written by the European Respiratory Society, states that it is the maximum flow achieved during the expiration phase, delivered with maximal force, starting from the maximum level of lung inflation. The aim of this study was to evaluate the variations of PEF associated with height, age, body surface area, place of residence and environmental factors among healthy adults in an urban setting in Poland. Material and methods: The study comprised 88 healthy, non-smoking subjects: 30 females and 58 males, aged 20–80 years. Epidemiological and demographic data were collected from each participant, as well as information on symptoms and the occurrence of lung diseases. Only healthy subjects were selected for analysis. Participants completed spirometry testing; physical parameters were measured, and appropriate additional data obtained. Results: Among the study group of 88 participants (30 females and 58 males), peak expiratory flow rate was negatively correlated with age (p = 0.000001), and positively correlated with height and body surface area (both p < 0.000001). There was a significant negative correlation between PEF and longitudinal environmental factors such as different particulate matter levels (p = 0.0007) present at the place of residence. Conclusions: Peak expiratory flow changes are present in a healthy adult population. Place of residence and environmental factors influence the results of spirometry tests.
{"title":"Comparing variations of peak expiratory flow among healthy adults from the Kuyavia-Pomeranian and Lublin districts of Poland","authors":"Maciej Składanowski, P. Jarosz, B. Maćkiewicz","doi":"10.5114/AMSCD.2019.81666","DOIUrl":"https://doi.org/10.5114/AMSCD.2019.81666","url":null,"abstract":"Introduction: Peak expiratory flow (PEF), a measure of lung function, was first described by Hadorn in 1942. The definition of PEF, written by the European Respiratory Society, states that it is the maximum flow achieved during the expiration phase, delivered with maximal force, starting from the maximum level of lung inflation. The aim of this study was to evaluate the variations of PEF associated with height, age, body surface area, place of residence and environmental factors among healthy adults in an urban setting in Poland. Material and methods: The study comprised 88 healthy, non-smoking subjects: 30 females and 58 males, aged 20–80 years. Epidemiological and demographic data were collected from each participant, as well as information on symptoms and the occurrence of lung diseases. Only healthy subjects were selected for analysis. Participants completed spirometry testing; physical parameters were measured, and appropriate additional data obtained. Results: Among the study group of 88 participants (30 females and 58 males), peak expiratory flow rate was negatively correlated with age (p = 0.000001), and positively correlated with height and body surface area (both p < 0.000001). There was a significant negative correlation between PEF and longitudinal environmental factors such as different particulate matter levels (p = 0.0007) present at the place of residence. Conclusions: Peak expiratory flow changes are present in a healthy adult population. Place of residence and environmental factors influence the results of spirometry tests.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115453941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2020.100979
S. Konur
to examine a relationship between diabetic regulation and diabetic complications as well as endoscopic findings in patients with DM and dyspeptic complaints. Material methods: DM diagnosis endoscopy for the upper gastrointestinal included. Diagnosis of DM was made according to the American Diabetes Association (ADA) criteria. Diabetic complications were questioned. A relationship between endoscopic and histopathological findings, glycated hemoglobin (HbA 1c ) level, and complications was investigated. Results: A total of 105 patients, 61 (58%) females, were included into the study. In a comparison between the groups, there was no statistically significant difference between glycemic regulation and endoscopic findings and the presence of HP. Comparing diabetic complications, no significant difference was observed in patients with complications from the endoscopic findings, except for pangastritis. The presence of HP was similar in both groups. Conclusions: It can be said that endoscopic findings and presence of HP are not closely related to glycemic control and complications in diabetic patients. However, these results should be supported by larger, multi-center, prospective studies.
{"title":"A relationship between endoscopic findings \u0000and diabetic regulation, and complications in patients with diabetes mellitus","authors":"S. Konur","doi":"10.5114/amscd.2020.100979","DOIUrl":"https://doi.org/10.5114/amscd.2020.100979","url":null,"abstract":"to examine a relationship between diabetic regulation and diabetic complications as well as endoscopic findings in patients with DM and dyspeptic complaints. Material methods: DM diagnosis endoscopy for the upper gastrointestinal included. Diagnosis of DM was made according to the American Diabetes Association (ADA) criteria. Diabetic complications were questioned. A relationship between endoscopic and histopathological findings, glycated hemoglobin (HbA 1c ) level, and complications was investigated. Results: A total of 105 patients, 61 (58%) females, were included into the study. In a comparison between the groups, there was no statistically significant difference between glycemic regulation and endoscopic findings and the presence of HP. Comparing diabetic complications, no significant difference was observed in patients with complications from the endoscopic findings, except for pangastritis. The presence of HP was similar in both groups. Conclusions: It can be said that endoscopic findings and presence of HP are not closely related to glycemic control and complications in diabetic patients. However, these results should be supported by larger, multi-center, prospective studies.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"556 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116518132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.107845
A. Khaleel, R. Shaari, M. Nawi, Ali Mihsen Hussein Al-yassiri
{"title":"Assessment of the protective effect of green tea extract against ciprofloxacin-induced chondrotoxicity \u0000in albino rats (histochemical, and immunohistochemical study)","authors":"A. Khaleel, R. Shaari, M. Nawi, Ali Mihsen Hussein Al-yassiri","doi":"10.5114/AMSCD.2021.107845","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.107845","url":null,"abstract":"","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"290 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122776276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2023.129194
Satomi Iwai, Shou Kobayashi, Eiji Kobayashi, Kazuhisa Sugai, Y. Hakamata, K. Shirakawa, Yoshinori Katsumata, M. Sano
hot water in an 80-litre bathtub. Two hairless mini pigs (14.2 ±1.4 kg, 60 days old, 1 male and 1 female) were first placed in the H 2 -dissolved bath. After a washout period, one pig was bathed in an H 2 -dissolved bath and the other in a bath containing no H 2 for 20 min. During the experiment, blood was collected from the pigs’ jugular vein, carotid artery, inferior vena cava (IVCs), and portal vein to measure the blood H 2 concentration. Results: The H 2 concentration at the IVC of the pig in the H 2 -dissolved bath increased from 0.733 ±0.636 ppb (w/w) to 16.9 ±4.46 ppb (w/w) after 2 min, 37.2 ±13.8 ppb (w/w) after 10 min, and 45.7 ±7.73 ppb (w/w) (H 2 saturation level: 3%) after 20 min. The blood H 2 concentration levels of the pig in the non-H 2 bath remained below the detection limit of 0.3 ppb. Conclusions: Bathing in water with a high concentration of dissolved hydrogen was considered an effective means of supplying H 2 to skin tissues and beyond.
{"title":"Direct evidence of hydrogen absorption from the skin – a pig study","authors":"Satomi Iwai, Shou Kobayashi, Eiji Kobayashi, Kazuhisa Sugai, Y. Hakamata, K. Shirakawa, Yoshinori Katsumata, M. Sano","doi":"10.5114/amscd.2023.129194","DOIUrl":"https://doi.org/10.5114/amscd.2023.129194","url":null,"abstract":"hot water in an 80-litre bathtub. Two hairless mini pigs (14.2 ±1.4 kg, 60 days old, 1 male and 1 female) were first placed in the H 2 -dissolved bath. After a washout period, one pig was bathed in an H 2 -dissolved bath and the other in a bath containing no H 2 for 20 min. During the experiment, blood was collected from the pigs’ jugular vein, carotid artery, inferior vena cava (IVCs), and portal vein to measure the blood H 2 concentration. Results: The H 2 concentration at the IVC of the pig in the H 2 -dissolved bath increased from 0.733 ±0.636 ppb (w/w) to 16.9 ±4.46 ppb (w/w) after 2 min, 37.2 ±13.8 ppb (w/w) after 10 min, and 45.7 ±7.73 ppb (w/w) (H 2 saturation level: 3%) after 20 min. The blood H 2 concentration levels of the pig in the non-H 2 bath remained below the detection limit of 0.3 ppb. Conclusions: Bathing in water with a high concentration of dissolved hydrogen was considered an effective means of supplying H 2 to skin tissues and beyond.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130973210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.86992
Carlos Gustavo Camara Puppin, F. Moraes, L. Gomes, A. Nascimento, E. Lima, G. Brasil, N. Bissoli, D. Lenz, D. Endringer, T. U. Andrade
Introduction: Anabolic androgenic steroids (AASs) can induce cardiac dysautonomia, which is related to arrhythmias, vasovagal syncope (VVS) and sudden death. The aim of this study was to determine whether the use of AASs increases the susceptibility for VVS or autonomic dysfunction in AAS users by the head-up tilt test (HUTT). Material and methods: Cross-sectional observational study conducted with physically active young men, users (AAS group; n = 10) and non-users (Control group, n = 13) of AAS. The history of physical activity and age of each participant were recorded and the following examinations were performed: physical, biochemical, hormonal, electrocardiogram (ECG), 24-hour Holter recorder equipment. The 24-hour Holter and HUTT were conducted to detect the presence of arrhythmias/heart rate variability, and VVS/dysautonomia, respectively. Of the 28 participants recruited, 5 were excluded for not having completed the examinations. Results: Compared with non-users, users of AAS showed an increase in aspartate aminotransferase (Control: 29.7 ±1.8; AAS: 49.9 ±9.0 UI/l; p < 0.05), in ventricular extrasystoles (Control: 2.5 ±2.3; AAS: 14.9 ±11.2, p < 0.05), and reduction in the pNN50 index of Holter (Control: 24.3 ±4.0%; AAS: 14.8 ±4.0%, p < 0.05). The HUTT showed that the maximum value of diastolic blood pressure was increased in the AAS user group (Control: 78.3 ±2.1; AAS: 90.0 ±5.4 mm Hg, p < 0.05). Conclusions: The study showed that the use of AAS is able to promote an autonomic dysfunction, with a ventricular arrhythmia. In addition it was found that among AAS users there was a positive result for the HUTT.
{"title":"Anabolic androgenic steroid users: a tilt test study with young adult men","authors":"Carlos Gustavo Camara Puppin, F. Moraes, L. Gomes, A. Nascimento, E. Lima, G. Brasil, N. Bissoli, D. Lenz, D. Endringer, T. U. Andrade","doi":"10.5114/amscd.2019.86992","DOIUrl":"https://doi.org/10.5114/amscd.2019.86992","url":null,"abstract":"Introduction: Anabolic androgenic steroids (AASs) can induce cardiac dysautonomia, which is related to arrhythmias, vasovagal syncope (VVS) and sudden death. The aim of this study was to determine whether the use of AASs increases the susceptibility for VVS or autonomic dysfunction in AAS users by the head-up tilt test (HUTT). Material and methods: Cross-sectional observational study conducted with physically active young men, users (AAS group; n = 10) and non-users (Control group, n = 13) of AAS. The history of physical activity and age of each participant were recorded and the following examinations were performed: physical, biochemical, hormonal, electrocardiogram (ECG), 24-hour Holter recorder equipment. The 24-hour Holter and HUTT were conducted to detect the presence of arrhythmias/heart rate variability, and VVS/dysautonomia, respectively. Of the 28 participants recruited, 5 were excluded for not having completed the examinations. Results: Compared with non-users, users of AAS showed an increase in aspartate aminotransferase (Control: 29.7 ±1.8; AAS: 49.9 ±9.0 UI/l; p < 0.05), in ventricular extrasystoles (Control: 2.5 ±2.3; AAS: 14.9 ±11.2, p < 0.05), and reduction in the pNN50 index of Holter (Control: 24.3 ±4.0%; AAS: 14.8 ±4.0%, p < 0.05). The HUTT showed that the maximum value of diastolic blood pressure was increased in the AAS user group (Control: 78.3 ±2.1; AAS: 90.0 ±5.4 mm Hg, p < 0.05). Conclusions: The study showed that the use of AAS is able to promote an autonomic dysfunction, with a ventricular arrhythmia. In addition it was found that among AAS users there was a positive result for the HUTT.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115687764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2019.86922
K. Styczkiewicz, P. Kukla, A. Czerkies-Bieleń, M. Styczkiewicz
Corresponding author: Katarzyna Styczkiewicz MD, PhD Department of Cardiology Brzozów Specialist Hospital Subcarpathian Oncological Center 18 Bielawskiego St 36-200 Brzozow, Poland Phone: + 48 13 4307940 Fax: + 48 13 4307940 E-mail: krachwal@interia.pl 1 Department of Cardiology, Brzozów Specialist Hospital, Subcarpathian Oncological Center, Brzozow, Poland 2Department of Cardiology and Internal Medicine, Specialist Hospital, Gorlice, Poland
通讯作者:Katarzyna Styczkiewicz医学博士心脏病科Brzozów专科医院Subcarpathian oncology Center 18 Bielawskiego St 36-200 brzozoow，波兰电话:+ 48 13 4307940传真:+ 48 13 4307940 E-mail: krachwal@interia.pl 1心脏病科，Brzozów专科医院，Subcarpathian oncology Center, brzozoow，波兰2专科医院心脏病和内科，Gorlice，波兰
{"title":"Between fire and flood. Drug-induced QT prolongation causes torsades de pointes and electrical storm","authors":"K. Styczkiewicz, P. Kukla, A. Czerkies-Bieleń, M. Styczkiewicz","doi":"10.5114/AMSCD.2019.86922","DOIUrl":"https://doi.org/10.5114/AMSCD.2019.86922","url":null,"abstract":"Corresponding author: Katarzyna Styczkiewicz MD, PhD Department of Cardiology Brzozów Specialist Hospital Subcarpathian Oncological Center 18 Bielawskiego St 36-200 Brzozow, Poland Phone: + 48 13 4307940 Fax: + 48 13 4307940 E-mail: krachwal@interia.pl 1 Department of Cardiology, Brzozów Specialist Hospital, Subcarpathian Oncological Center, Brzozow, Poland 2Department of Cardiology and Internal Medicine, Specialist Hospital, Gorlice, Poland","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"166 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114432266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2022.122272
Akif Khurshid, Z. Parveen, Muddasir Jan, Mohammad Assad
{"title":"Association of causes of type 2 diabetes mellitus and gestational diabetes with the clinical profile in the population of Khyber Pakhtunkhwa Pakistan","authors":"Akif Khurshid, Z. Parveen, Muddasir Jan, Mohammad Assad","doi":"10.5114/amscd.2022.122272","DOIUrl":"https://doi.org/10.5114/amscd.2022.122272","url":null,"abstract":"","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114608862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2020.100881
H. Pınar, M. Dinçer, Y. Ilhan
of rats weighing 280 to 330 g were divided into four equal groups. 5 ml of 0.9% NaCl was given to the control group, 5 ml of methylprednisolone was given to group 2, 5 ml of vitamin E to group 3 and 5 ml of nedocromil sodium to group 4 were given intraabdominally. On the 14 th postoperative day, all rats were sacrificed and re-laparotomy was performed. Intraabdominal adhesions were scored according to the Nair classification. Results: When the groups were compared dyadically, the difference between group 1 and group 2 was found to be statistically significant ( p = 0.011). The difference between group 1 and group 3 was statistically significant ( p = 0.011). The difference between group and group 4 ( p = 0.007). There was no statistically significant difference between group 2 and group 3, and group 2 and group 4, and group 3 and group 4 ( p < 0.05). Conclusions: As a result, methylprednisolone, vitamin E and nedocromil sodium have been shown to have a healing effect on adhesions.
{"title":"Effects of vitamin E, methylprednisolone and nedocromil sodium on healing of rats with experimentally created intraabdominal adhesions","authors":"H. Pınar, M. Dinçer, Y. Ilhan","doi":"10.5114/amscd.2020.100881","DOIUrl":"https://doi.org/10.5114/amscd.2020.100881","url":null,"abstract":"of rats weighing 280 to 330 g were divided into four equal groups. 5 ml of 0.9% NaCl was given to the control group, 5 ml of methylprednisolone was given to group 2, 5 ml of vitamin E to group 3 and 5 ml of nedocromil sodium to group 4 were given intraabdominally. On the 14 th postoperative day, all rats were sacrificed and re-laparotomy was performed. Intraabdominal adhesions were scored according to the Nair classification. Results: When the groups were compared dyadically, the difference between group 1 and group 2 was found to be statistically significant ( p = 0.011). The difference between group 1 and group 3 was statistically significant ( p = 0.011). The difference between group and group 4 ( p = 0.007). There was no statistically significant difference between group 2 and group 3, and group 2 and group 4, and group 3 and group 4 ( p < 0.05). Conclusions: As a result, methylprednisolone, vitamin E and nedocromil sodium have been shown to have a healing effect on adhesions.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129125831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.105824
A. Gąsecka, Olga Jakubik, Paulina Putowska, A. Pietrasik
Single coronary artery (SCA) is one of the rarest congenital coronary artery anomalies, with the incidence ranging from 0.01% to 0.07% [1]. SCA can be either an isolated anomaly or associated with other congenital abnormalities such as bicuspid aortic valve. Most of the cases of SCA are asymptomatic. The malignant variety of SCA is the type in which SCA is located between the aorta and the pulmonary artery [2]. An 83-year-old woman with suspected chronic coronary syndrome (CCS) was admitted to the cardiology department for elective coronary angiography. While performing the procedure, it was difficult to cannulate the left main artery in the left aortic sinus with JL4 and JL3.5 standard catheters. The right coronary ostium was engaged with a JR4 catheter, demonstrating a superdominant right coronary artery with additional left anterior descending and circumflex arteries arising from the right coronary ostium (Figures 1 A, B). There were no significant atherosclerotic lesions in any of the branches. The patient received conservative treatment and was discharged from the hospital 1 day later. Based on the site of origin and anatomical distribution of the branches, SCA is classified into 2 main categories: “R,” right type, and “L,” left type. In 75% of the cases, the artery is located between the aorta and the pulmonary artery, leading to an increased risk of sudden cardiac death due to its compression [2]. Therefore, additional assessment of the course of the vessel using computed tomography should be considered as a routine diagnostic approach [3]. Approximately 30% of the patients with malignant artery course die during the first 2 decades of life [4]. However, the clinical course in our patient was uneventful. The co-existence of SCA with CCS can have a significant impact on the course of CCS and prognosis. The anomaly may pose a diagnosis and treatment challenge during coronary catheterization and revascularisation procedures.
{"title":"Single coronary artery anomaly","authors":"A. Gąsecka, Olga Jakubik, Paulina Putowska, A. Pietrasik","doi":"10.5114/AMSCD.2021.105824","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.105824","url":null,"abstract":"Single coronary artery (SCA) is one of the rarest congenital coronary artery anomalies, with the incidence ranging from 0.01% to 0.07% [1]. SCA can be either an isolated anomaly or associated with other congenital abnormalities such as bicuspid aortic valve. Most of the cases of SCA are asymptomatic. The malignant variety of SCA is the type in which SCA is located between the aorta and the pulmonary artery [2]. An 83-year-old woman with suspected chronic coronary syndrome (CCS) was admitted to the cardiology department for elective coronary angiography. While performing the procedure, it was difficult to cannulate the left main artery in the left aortic sinus with JL4 and JL3.5 standard catheters. The right coronary ostium was engaged with a JR4 catheter, demonstrating a superdominant right coronary artery with additional left anterior descending and circumflex arteries arising from the right coronary ostium (Figures 1 A, B). There were no significant atherosclerotic lesions in any of the branches. The patient received conservative treatment and was discharged from the hospital 1 day later. Based on the site of origin and anatomical distribution of the branches, SCA is classified into 2 main categories: “R,” right type, and “L,” left type. In 75% of the cases, the artery is located between the aorta and the pulmonary artery, leading to an increased risk of sudden cardiac death due to its compression [2]. Therefore, additional assessment of the course of the vessel using computed tomography should be considered as a routine diagnostic approach [3]. Approximately 30% of the patients with malignant artery course die during the first 2 decades of life [4]. However, the clinical course in our patient was uneventful. The co-existence of SCA with CCS can have a significant impact on the course of CCS and prognosis. The anomaly may pose a diagnosis and treatment challenge during coronary catheterization and revascularisation procedures.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116566372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.86742
Nermine El Maraghy, Manal M. Said, Rasha Emad, M. Salama, A. Hashish
Introduction: Metallo-β-lactamase production among Pseudomonas aeruginosa is a major health problem worldwide. Pseudomonas aeruginosa acquire several mechanisms of resistance towards carbapenems through the production of metallo-β-lactamases, especially VIM and IMP. The problem of multi-drug-resistant Pseudomonas aeruginosa is increasing all over the world, reaching dangerous levels. The aim of this study was to detect the metallo-β-lactamases blaVIM and blaIMP genes in Pseudomonas aeruginosa strains in Suez Canal University Hospital in Ismailia, Egypt. Material and methods: A cross-sectional descriptive study was conducted on 65 Pseudomonas aeruginosa strains. Genotypic detection of blaVIM and blaIMP was reached by using polymerase chain reaction. Results: Out of 65 Pseudomonas aeruginosa strains , blaVIM gene was present in four females and one male, with an age of 42.9 ±18.1; two cases were isolated from the Oncology Department, and one case each was present in the Burn Unit, Surgery Ward, and Intensive Care Unit. The blaVIM gene was expressed in four stains, while the bla IMP gene was not expressed in any strain. Conclusions: The carbapenem resistance in our patients can be referred to as metallo-β-lactamases blaVIM type. The problem of metallo-β-lactamases and carbapenem resistance requires ongoing surveillance, strong preventive measures, and implementation of infection control policies and procedures. Also, routine diagnostic laboratory methods should be performed, and synthesis of antimicrobial products with new effecting mechanism should be implemented in hospitals.
{"title":"Detection of IMP and VIM genes in Pseudomonas aeruginosa isolated from Egyptian patients","authors":"Nermine El Maraghy, Manal M. Said, Rasha Emad, M. Salama, A. Hashish","doi":"10.5114/amscd.2019.86742","DOIUrl":"https://doi.org/10.5114/amscd.2019.86742","url":null,"abstract":"Introduction: Metallo-β-lactamase production among Pseudomonas aeruginosa is a major health problem worldwide. Pseudomonas aeruginosa acquire several mechanisms of resistance towards carbapenems through the production of metallo-β-lactamases, especially VIM and IMP. The problem of multi-drug-resistant Pseudomonas aeruginosa is increasing all over the world, reaching dangerous levels. The aim of this study was to detect the metallo-β-lactamases blaVIM and blaIMP genes in Pseudomonas aeruginosa strains in Suez Canal University Hospital in Ismailia, Egypt. Material and methods: A cross-sectional descriptive study was conducted on 65 Pseudomonas aeruginosa strains. Genotypic detection of blaVIM and blaIMP was reached by using polymerase chain reaction. Results: Out of 65 Pseudomonas aeruginosa strains , blaVIM gene was present in four females and one male, with an age of 42.9 ±18.1; two cases were isolated from the Oncology Department, and one case each was present in the Burn Unit, Surgery Ward, and Intensive Care Unit. The blaVIM gene was expressed in four stains, while the bla IMP gene was not expressed in any strain. Conclusions: The carbapenem resistance in our patients can be referred to as metallo-β-lactamases blaVIM type. The problem of metallo-β-lactamases and carbapenem resistance requires ongoing surveillance, strong preventive measures, and implementation of infection control policies and procedures. Also, routine diagnostic laboratory methods should be performed, and synthesis of antimicrobial products with new effecting mechanism should be implemented in hospitals.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"199 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122394916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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