Pub Date : 1900-01-01DOI: 10.5114/amscd.2020.94102
A. Kubicka-Trząska, K. Morawski, A. Markiewicz, B. Romanowska-Dixon
Introduction: The aim of this study was to evaluate the efficacy and safety of endoresection for choroidal melanoma to prevent and treat the toxic tumour syndrome (TTS). Material and methods: Thirteen patients who underwent primary proton beam therapy (PBRT) for choroidal melanoma followed by endoresection were evaluated. Main outcome measures were functional and anatomical results, surgical complications, rate of local recurrence, presence or absence of metastatic spread. Results: The median time of the follow-up period was 61.6 months. Six patients with clinical signs of TTS and seven with large tumours to prevent TTS underwent endoresection. Tumour thickness was 5.8 to 9.3 mm (mean: 7.6), the basal diameters were 10.6 to 15.0 mm (mean: 13.4). Preoperative best corrected visual acuity (BCVA) was 6/7.5 to counting fingers and the final BCVA was 6/15 to no light perception, and was better in those treated to prevent TTS ( p = 0.01). The most universal early postoperative complication was bleeding from the scleral bed. The most common late postoperative complications were epiretinal membrane formation (30.8%), cystoid macular oedema (23.1%) and silicone oil-induced glaucoma (15.4%). Two (15.4%) patients developed phthisis bulbi, neither developed local recurrence. One patient developed liver metastases. Conclusions: Endoresection for choroidal melanoma is a safe and effective procedure with a high rate of local tumour control. The procedure appears to be useful in the prophylaxis and treatment of TTS after PBRT of choroidal melanoma.
{"title":"Prevention and treatment of the toxic tumour syndrome following primary proton beam therapy of choroidal melanomas","authors":"A. Kubicka-Trząska, K. Morawski, A. Markiewicz, B. Romanowska-Dixon","doi":"10.5114/amscd.2020.94102","DOIUrl":"https://doi.org/10.5114/amscd.2020.94102","url":null,"abstract":"Introduction: The aim of this study was to evaluate the efficacy and safety of endoresection for choroidal melanoma to prevent and treat the toxic tumour syndrome (TTS). Material and methods: Thirteen patients who underwent primary proton beam therapy (PBRT) for choroidal melanoma followed by endoresection were evaluated. Main outcome measures were functional and anatomical results, surgical complications, rate of local recurrence, presence or absence of metastatic spread. Results: The median time of the follow-up period was 61.6 months. Six patients with clinical signs of TTS and seven with large tumours to prevent TTS underwent endoresection. Tumour thickness was 5.8 to 9.3 mm (mean: 7.6), the basal diameters were 10.6 to 15.0 mm (mean: 13.4). Preoperative best corrected visual acuity (BCVA) was 6/7.5 to counting fingers and the final BCVA was 6/15 to no light perception, and was better in those treated to prevent TTS ( p = 0.01). The most universal early postoperative complication was bleeding from the scleral bed. The most common late postoperative complications were epiretinal membrane formation (30.8%), cystoid macular oedema (23.1%) and silicone oil-induced glaucoma (15.4%). Two (15.4%) patients developed phthisis bulbi, neither developed local recurrence. One patient developed liver metastases. Conclusions: Endoresection for choroidal melanoma is a safe and effective procedure with a high rate of local tumour control. The procedure appears to be useful in the prophylaxis and treatment of TTS after PBRT of choroidal melanoma.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129736569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2022.119965
Georgios Zacharakis, Abdulaziz S Almasoud, K. Aldossari
to continue enhance citizen participation and overcome the barriers of CRC screening such as physician recommendation and female gender low participation.
继续提高公民参与，克服医生推荐和女性参与率低等障碍。
{"title":"Colorectal cancer screening challenges in Saudi Arabia. A comprehensive review article","authors":"Georgios Zacharakis, Abdulaziz S Almasoud, K. Aldossari","doi":"10.5114/amscd.2022.119965","DOIUrl":"https://doi.org/10.5114/amscd.2022.119965","url":null,"abstract":"to continue enhance citizen participation and overcome the barriers of CRC screening such as physician recommendation and female gender low participation.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132698534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2022.119197
Mariah Nascimento, A. L. Silva Galbiatti-Dias, J. Oliveira-Cucolo, É. Pavarino, E. M. Goloni-Bertollo
{"title":"Influence of standardization of human papillomavirus diagnosis in head and neck cancer treatment","authors":"Mariah Nascimento, A. L. Silva Galbiatti-Dias, J. Oliveira-Cucolo, É. Pavarino, E. M. Goloni-Bertollo","doi":"10.5114/amscd.2022.119197","DOIUrl":"https://doi.org/10.5114/amscd.2022.119197","url":null,"abstract":"","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"31 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116318129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.91449
O. Özdoğan, Serkan Yaraş
Introduction: Studies of Helicobacter pylori (HP) in liver diseases and hepatitis B virus (HBV) infection have been increasingly discussed. Most studies investigating the relationship between HP and HBV have been conducted in patients with cirrhosis and hepatocellular carcinoma (HCC) and usually involving noninvasive tests. The HP frequency in these patients was higher than in healthy controls. No histopathological evaluation was performed in these studies. We investigated the incidence of HP in HBeAg-negative chronic HBV infection (previously termed “inactive carrier”) by using invasive gastric biopsies and carried out histopathological evaluation. Material and methods: We included 90 treatment-naive inactive hepatitis-B carriers as patients. The control group comprised 107 healthy subjects. Biopsies were obtained from the antrum and corpus and were evaluated histopathologically using the Sydney system of classification for gastritis. Results: The rate of HP in inactive hepatitis-B carriers was significantly higher than the control group (75.6% vs. 53.3%, respectively; p = 0.001). There was no difference in incidence of atrophy, intestinal metaplasia, activity, or inflammation (p > 0.05). Peptic ulcer was detected in 11 (12.2%) patients in the HBV group and in 7 (6.5%) patients in the control group (p = 0.360). The incidence of HP was higher in patients with HBV DNA ≥ 2000 IU/ml than in patients with HBV DNA < 2000 IU/ml, but this difference was not statistically significant (85% vs. 68%, respectively; p = 0.062). Conclusions: Although the HP rate in inactive hepatitis-B carriers was higher than the control group, there were no intergroup differences with respect to atrophy, intestinal metaplasia, activity, inflammation, and peptic ulcer frequency.
导读:幽门螺杆菌(HP)在肝脏疾病和乙型肝炎病毒(HBV)感染中的研究越来越受到关注。大多数调查HP和HBV之间关系的研究都是在肝硬化和肝细胞癌(HCC)患者中进行的，通常包括非侵入性检查。这些患者的HP频率高于健康对照组。在这些研究中没有进行组织病理学评估。我们通过侵入性胃活检和组织病理学评估，调查了hbeag阴性慢性HBV感染(以前称为“无活性携带者”)中HP的发病率。材料和方法:我们纳入90例初次治疗的非活动性乙型肝炎携带者作为患者。对照组为107名健康受试者。从胃窦和胃体进行活检，并使用胃炎的悉尼分类系统进行组织病理学评估。结果:非活动性乙肝病毒携带者HP感染率显著高于对照组(75.6% vs. 53.3%;P = 0.001)。两组间萎缩、肠化生、活动性和炎症的发生率均无差异(p > 0.05)。HBV组有11例(12.2%)出现消化性溃疡，对照组有7例(6.5%)出现消化性溃疡(p = 0.360)。HBV DNA≥2000 IU/ml的患者HP发病率高于HBV DNA < 2000 IU/ml的患者，但差异无统计学意义(分别为85% vs. 68%;P = 0.062)。结论:虽然非活动性乙型肝炎携带者的HP发生率高于对照组，但在萎缩、肠化生、活动性、炎症和消化性溃疡发生率方面，组间无差异。
{"title":"Helicobacter pylori rate and histopathological evaluation in HBeAg-negative chronic hepatitis B virus infection","authors":"O. Özdoğan, Serkan Yaraş","doi":"10.5114/amscd.2019.91449","DOIUrl":"https://doi.org/10.5114/amscd.2019.91449","url":null,"abstract":"Introduction: Studies of Helicobacter pylori (HP) in liver diseases and hepatitis B virus (HBV) infection have been increasingly discussed. Most studies investigating the relationship between HP and HBV have been conducted in patients with cirrhosis and hepatocellular carcinoma (HCC) and usually involving noninvasive tests. The HP frequency in these patients was higher than in healthy controls. No histopathological evaluation was performed in these studies. We investigated the incidence of HP in HBeAg-negative chronic HBV infection (previously termed “inactive carrier”) by using invasive gastric biopsies and carried out histopathological evaluation. Material and methods: We included 90 treatment-naive inactive hepatitis-B carriers as patients. The control group comprised 107 healthy subjects. Biopsies were obtained from the antrum and corpus and were evaluated histopathologically using the Sydney system of classification for gastritis. Results: The rate of HP in inactive hepatitis-B carriers was significantly higher than the control group (75.6% vs. 53.3%, respectively; p = 0.001). There was no difference in incidence of atrophy, intestinal metaplasia, activity, or inflammation (p > 0.05). Peptic ulcer was detected in 11 (12.2%) patients in the HBV group and in 7 (6.5%) patients in the control group (p = 0.360). The incidence of HP was higher in patients with HBV DNA ≥ 2000 IU/ml than in patients with HBV DNA < 2000 IU/ml, but this difference was not statistically significant (85% vs. 68%, respectively; p = 0.062). Conclusions: Although the HP rate in inactive hepatitis-B carriers was higher than the control group, there were no intergroup differences with respect to atrophy, intestinal metaplasia, activity, inflammation, and peptic ulcer frequency.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"106 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124160218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.105525
B. Kanat, F. Cay, N. Kutluer, Nurullah Aksoy, M. Bozan, Ö. Solmaz, Z. Karagöz, Sinan Irtegün, Y. Aydin
of calculated analysed according to the of the patients (gender and preoperative thyroid nodule sizes, and postoperative pathological mass sizes. age, preoperative nodule size, and tumour size evaluated according to There were a total of 60 patients (14 (23%) male and 46 (77%) fe-male). The pathology revealed 16 (26.7%) malignant and 44 (73.3%) benign biopsies. The mean age was 46.72 ±12.08 years (20–74). We found that age, preoperative nodule size (cm), pathological tumour size (cm), and thyroid function tests were not significantly associated with malignancy. However, when age, preoperative nodule size, and tumour sizes were evaluated according to gender, it was found that tumour sizes were significantly larger in men than in women ( p < 0.001). In addition, the mean age of male patients was higher than that of women ( p = 0.025). Conclusions: The malignancy rate has increased in the thyroidectomies performed in our centre. This finding is consistent with relevant studies from the last 30 years. Therefore, it is likely that clinicians will continue to handle an increased number of thyroid malignancies.
{"title":"Have malignancy rates increased in thyroidectomy cases?","authors":"B. Kanat, F. Cay, N. Kutluer, Nurullah Aksoy, M. Bozan, Ö. Solmaz, Z. Karagöz, Sinan Irtegün, Y. Aydin","doi":"10.5114/AMSCD.2021.105525","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.105525","url":null,"abstract":"of calculated analysed according to the of the patients (gender and preoperative thyroid nodule sizes, and postoperative pathological mass sizes. age, preoperative nodule size, and tumour size evaluated according to There were a total of 60 patients (14 (23%) male and 46 (77%) fe-male). The pathology revealed 16 (26.7%) malignant and 44 (73.3%) benign biopsies. The mean age was 46.72 ±12.08 years (20–74). We found that age, preoperative nodule size (cm), pathological tumour size (cm), and thyroid function tests were not significantly associated with malignancy. However, when age, preoperative nodule size, and tumour sizes were evaluated according to gender, it was found that tumour sizes were significantly larger in men than in women ( p < 0.001). In addition, the mean age of male patients was higher than that of women ( p = 0.025). Conclusions: The malignancy rate has increased in the thyroidectomies performed in our centre. This finding is consistent with relevant studies from the last 30 years. Therefore, it is likely that clinicians will continue to handle an increased number of thyroid malignancies.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128023365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.87003
S. Ueda, T. Ichiseki, Daisuke Soma, N. Kawahara
Introduction: The underlying pathophysiology of venous thromboembolism (VTE) in upper limb surgery has been scarcely reported. This prompted us to investigate, using transoesophageal echocardiography (TEE) intraoperatively, the impact on haemodynamics in reverse shoulder arthroplasty (RSA) as compared with total hip arthroplasty (THA). Material and methods: The subjects comprised five shoulders undergoing RSA (RSA group) in our department. In all cases TEE was performed intraoperatively, with the haemodynamic state of the right atrium and superior vena cava monitored throughout the intraoperative period. As investigated items, blood D-dimer values were measured and compared intraoperatively, on postoperative day 1, day 4, week 1, and week 2. As a control group, five cases undergoing THA under the same conditions were compared with the RSA group. Results: Intraoperatively, in both RSA and THA groups, echogenic emboli were identified in the right atrium on TEE during bone reaming and artificial joint insertion. No significant differences were found between the two groups with respect to intraoperative or postoperative D-dimer changes. Also, in neither group was deep vein thrombosis (DVT) or pulmonary embolism (PE) detected either by lower limb venous ultrasonography or lung ventilation-perfusion scintigraphy. Conclusions: Fat emboli occur as frequently in upper limb surgery as in lower limb surgery, and the possibility of fat embolism syndrome as a postoperative complication needs to be kept in mind. Measurement of D-dimer values is useful in the early detection of DVT in upper limb surgery.
{"title":"Right atrial fat emboli detection and changes in D-dimer values in reverse shoulder arthroplasty: a comparison with total hip arthroplasty","authors":"S. Ueda, T. Ichiseki, Daisuke Soma, N. Kawahara","doi":"10.5114/amscd.2019.87003","DOIUrl":"https://doi.org/10.5114/amscd.2019.87003","url":null,"abstract":"Introduction: The underlying pathophysiology of venous thromboembolism (VTE) in upper limb surgery has been scarcely reported. This prompted us to investigate, using transoesophageal echocardiography (TEE) intraoperatively, the impact on haemodynamics in reverse shoulder arthroplasty (RSA) as compared with total hip arthroplasty (THA). Material and methods: The subjects comprised five shoulders undergoing RSA (RSA group) in our department. In all cases TEE was performed intraoperatively, with the haemodynamic state of the right atrium and superior vena cava monitored throughout the intraoperative period. As investigated items, blood D-dimer values were measured and compared intraoperatively, on postoperative day 1, day 4, week 1, and week 2. As a control group, five cases undergoing THA under the same conditions were compared with the RSA group. Results: Intraoperatively, in both RSA and THA groups, echogenic emboli were identified in the right atrium on TEE during bone reaming and artificial joint insertion. No significant differences were found between the two groups with respect to intraoperative or postoperative D-dimer changes. Also, in neither group was deep vein thrombosis (DVT) or pulmonary embolism (PE) detected either by lower limb venous ultrasonography or lung ventilation-perfusion scintigraphy. Conclusions: Fat emboli occur as frequently in upper limb surgery as in lower limb surgery, and the possibility of fat embolism syndrome as a postoperative complication needs to be kept in mind. Measurement of D-dimer values is useful in the early detection of DVT in upper limb surgery.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"62 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131315252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.105385
N. Yılmaz, M. Yıldırım, Hanım Seval Savaş, H. Cicek, O. Sever
Despite advances in diagnostic and therapeutic methods, gastrointestinal (GI) cancers have both a high incidence and a high mortality rate. In addition to surgery, chemotherapy and radiotherapy, novel modalities such as immunotherapy are increasingly used in the treatment of these cancers. However, the prognosis in GI cancers remains poor despite the availability of these treatments, which prompted the search for new prognostic and predictive markers. High-mobility group box-1 (HMGB1) is a non-histone DNA protein which is known as a nuclear transcription factor. The search for new therapeutic targets has also gained importance. In this review, the prognostic and predictive role of HMGB1 in gastrointestinal cancers will be discussed in light of current literature.
{"title":"The role of HMGB1 in gastrointestinal cancers","authors":"N. Yılmaz, M. Yıldırım, Hanım Seval Savaş, H. Cicek, O. Sever","doi":"10.5114/AMSCD.2021.105385","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.105385","url":null,"abstract":"Despite advances in diagnostic and therapeutic methods, gastrointestinal (GI) cancers have both a high incidence and a high mortality rate. In addition to surgery, chemotherapy and radiotherapy, novel modalities such as immunotherapy are increasingly used in the treatment of these cancers. However, the prognosis in GI cancers remains poor despite the availability of these treatments, which prompted the search for new prognostic and predictive markers. High-mobility group box-1 (HMGB1) is a non-histone DNA protein which is known as a nuclear transcription factor. The search for new therapeutic targets has also gained importance. In this review, the prognostic and predictive role of HMGB1 in gastrointestinal cancers will be discussed in light of current literature.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"404 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116077859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2019.86741
N. Nermine, M. Shehata, Y. Madian, Mohamed Hussien BadrEldin
{"title":"Does treatment with sub-lingual allergen-specific immunotherapy reduce adenoid size and improve quality of life among Egyptian children?","authors":"N. Nermine, M. Shehata, Y. Madian, Mohamed Hussien BadrEldin","doi":"10.5114/AMSCD.2019.86741","DOIUrl":"https://doi.org/10.5114/AMSCD.2019.86741","url":null,"abstract":"","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124588252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.105408
Aziza Ahmed, S. Abdelkawi, M. Elgohary, Ayman Elshinawy, D. Fouad
Introduction: To compare the efficacy of bevacizumab and rose bengal photodynamic therapy (RB-PDT) in the treatment of corneal neovascularization (CNV). Material and methods: The study design included the induction of CNV by suture placement in three groups of New Zealand rabbits: (1) a group with CNV without any treatment; (2) a group treated with subconjunctival injection of bevacizumab (25 mg/eye); (3) a group treated with intravenous injection of rose bengal and exposed to 532 nm photodynamic therapy. For 4 weeks, the animals were followed up by slit-lamp to analyze the extent of CNV, evaluate the corneal protein secondary structure, and determine the oxidative stress index (OSI). Results: After 4 weeks, traces of neovascularization were observed only in the bevacizumab treated group with grade 0.5. The contents of α -helix and β -sheet were 17% and 61% in CNV, 32%, and 46% in bevacizumab and 40% and 36% in RB-PDT groups vs. 43% and 35% for the control group. Moreover, the percentage changes in the total oxidative status (TOS) for CNV, bevacizumab and RB-PDT groups were 97.1%, 14.6%, and 1.0%, respectively, with respect to the control. The total antioxidant status (TAC) showed no significant changes ( p > 0.05) for both treated groups. The percentage of changes in OSI was 15.9% and 1.3% in bevacizumab, and RB-PDT treated groups compared with the control group. Conclusions: Both modes of treatment were effective in the regression of CNV, but RB-PDT was more efficient than bevacizumab by improving the corneal protein secondary structure and the oxidative stress.
{"title":"Comparative study of the efficacy of bevacizumab \u0000and rose bengal photodynamic therapy for treatment of corneal neovascularization","authors":"Aziza Ahmed, S. Abdelkawi, M. Elgohary, Ayman Elshinawy, D. Fouad","doi":"10.5114/AMSCD.2021.105408","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.105408","url":null,"abstract":"Introduction: To compare the efficacy of bevacizumab and rose bengal photodynamic therapy (RB-PDT) in the treatment of corneal neovascularization (CNV). Material and methods: The study design included the induction of CNV by suture placement in three groups of New Zealand rabbits: (1) a group with CNV without any treatment; (2) a group treated with subconjunctival injection of bevacizumab (25 mg/eye); (3) a group treated with intravenous injection of rose bengal and exposed to 532 nm photodynamic therapy. For 4 weeks, the animals were followed up by slit-lamp to analyze the extent of CNV, evaluate the corneal protein secondary structure, and determine the oxidative stress index (OSI). Results: After 4 weeks, traces of neovascularization were observed only in the bevacizumab treated group with grade 0.5. The contents of α -helix and β -sheet were 17% and 61% in CNV, 32%, and 46% in bevacizumab and 40% and 36% in RB-PDT groups vs. 43% and 35% for the control group. Moreover, the percentage changes in the total oxidative status (TOS) for CNV, bevacizumab and RB-PDT groups were 97.1%, 14.6%, and 1.0%, respectively, with respect to the control. The total antioxidant status (TAC) showed no significant changes ( p > 0.05) for both treated groups. The percentage of changes in OSI was 15.9% and 1.3% in bevacizumab, and RB-PDT treated groups compared with the control group. Conclusions: Both modes of treatment were effective in the regression of CNV, but RB-PDT was more efficient than bevacizumab by improving the corneal protein secondary structure and the oxidative stress.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122431399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.89899
Selçuk Gülmez, N. Kurt
Introduction: Choledocholithiasis is one of the undesirable consequences of gallbladder stones. Identifying such patients before cholecystectomy will prevent biliary leakage which develops secondarily to stones in the common bile duct (CBD). Scoring systems can be useful for prevention of complications. Material and methods: A total of 201 patients with symptomatic cholecystolithiasis were prospectively evaluated with regards to stone presence in the CBD. These evaluations identified those patients suspected of having CBD stones. Parameters were established as clinically obstructive jaundice or acute cholangitis attack, biochemically abnormal liver functions tests (LFT), radiological identification of CBD stone or choledochal dilatation (> 8 mm) as revealed by ultrasonography (USG). Residual stone controls were conducted through abdominal USG and LFT in the 3rd and 6th postoperative months. The patients’ physical examinations were routinely conducted at each follow-up. Patients with common bile duct stones and those without were statistically compared as per the following data: age, sex, cholangitis, g-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), Aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholesterol, triglyceride, total bilirubin, direct bilirubin, CBD stone presence and choledochal size as revealed by USG. Results: The parameters of our scoring system were: choledocholithiasis and choledochal dilatation in USG, total and direct bilirubin elevation, cholangitis episode in the last month, elevated AST, ALT, ALP, GGT, age ≥ 55 and TG level. Twenty-seven patients had choledocholithiasis. With this scoring system, the minimum score required for preoperative ERCP was 9. The rate of simultaneous CBD stones was 13.4%. Conclusions: Selective cholangiography that uses this scoring system brings about more cost utility than that of its routine performance.
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