Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.86740
T. Sidiropoulou, Aikaterini Karaferi, George Stachtos, Maria Alepaki, A. Karakosta, M. Dauri, G. Kostopanagiotou
Introduction: Surgery and anaesthesia may affect the outcomes of cancer. The aim of the study was to evaluate the effect of propofol or sevoflurane on cancer biomarkers such as interleukins, adhesion molecules, and EGFR. Material and methods: Eighty patients scheduled for colorectal cancer surgery were randomised to either propofol or sevoflurane anaesthesia. Blood samples for interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor α (TNF-α), interferon α (IFN-α), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), sE-selectin, and sEGFR measurements were obtained before induction of anaesthesia, at the end of surgery, and 72 h postoperatively. Results: Complete samples were obtained from 71 patients. Demographic data and anaesthesia/surgery-related data were similar between the two groups. There were significant differences produced by sevoflurane vs. propofol on the sE-selectin (median (IQR) 57.1 (59.2) vs. 42.7 (22.9) ng/ml, p = 0.011) and sEGFR (median (IQR) 49905.7 (22673.5) vs. 25.657.2 (13842.1) ng/ml, p < 0.001) concentrations postoperatively, while sEGFR plasma levels also showed a significant difference during surgery (median (IQR) 32964.5 (14402.5) vs. 25567.0 (13315.4) ng/ml, p = 0.04). IL-10 levels were significantly higher in the propofol group postoperatively (median (IQR) 13.7 (18.5) vs. 14.9 (66.6) pg/ml, p = 0.05). Conclusions: Given the role of EGFR and adhesion molecules on tumour progression and the generation of metastases, the inhibitory effect of propofol observed in this study might prove useful in the future. Further studies in larger populations investigating the effect of anaesthetic agents on these biomarkers are warranted.
手术和麻醉可能影响癌症的预后。该研究的目的是评估异丙酚或七氟醚对癌症生物标志物(如白细胞介素、粘附分子和EGFR)的影响。材料和方法:80例结肠直肠癌手术患者随机分为异丙酚组和七氟醚组。在麻醉诱导前、手术结束时和术后72 h采集血液样本，检测白细胞介素(IL)-6、IL-8、IL-10、肿瘤坏死因子α (TNF-α)、干扰素α (IFN-α)、可溶性细胞内粘附分子-1 (sICAM-1)、可溶性血管细胞粘附分子-1 (sVCAM-1)、硒选择素和sEGFR。结果:71例患者标本完整。两组的人口学数据和麻醉/手术相关数据相似。七氟醚与异丙酚对术后se -选择素(中位数(IQR) 57.1 (59.2) vs. 42.7 (22.9) ng/ml, p = 0.011)和sEGFR(中位数(IQR) 49905.7 (22673.5) vs. 25.657.2 (13842.1) ng/ml, p < 0.001)浓度产生显著差异，术中sEGFR血浆水平也显示显著差异(中位数(IQR) 32964.5 (14402.5) vs. 25567.0 (13315.4) ng/ml, p = 0.04)。术后异丙酚组IL-10水平明显升高(IQR中位数为13.7(18.5)比14.9 (66.6)pg/ml, p = 0.05)。结论:考虑到EGFR和粘附分子在肿瘤进展和转移产生中的作用，本研究中观察到的异丙酚的抑制作用可能在未来被证明是有用的。在更大的人群中进一步研究麻醉药对这些生物标志物的影响是有必要的。
{"title":"Propofol but not sevoflurane decreases circulating levels of sEGFR and sE-selectin after colorectal cancer surgery","authors":"T. Sidiropoulou, Aikaterini Karaferi, George Stachtos, Maria Alepaki, A. Karakosta, M. Dauri, G. Kostopanagiotou","doi":"10.5114/amscd.2019.86740","DOIUrl":"https://doi.org/10.5114/amscd.2019.86740","url":null,"abstract":"Introduction: Surgery and anaesthesia may affect the outcomes of cancer. The aim of the study was to evaluate the effect of propofol or sevoflurane on cancer biomarkers such as interleukins, adhesion molecules, and EGFR. Material and methods: Eighty patients scheduled for colorectal cancer surgery were randomised to either propofol or sevoflurane anaesthesia. Blood samples for interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor α (TNF-α), interferon α (IFN-α), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), sE-selectin, and sEGFR measurements were obtained before induction of anaesthesia, at the end of surgery, and 72 h postoperatively. Results: Complete samples were obtained from 71 patients. Demographic data and anaesthesia/surgery-related data were similar between the two groups. There were significant differences produced by sevoflurane vs. propofol on the sE-selectin (median (IQR) 57.1 (59.2) vs. 42.7 (22.9) ng/ml, p = 0.011) and sEGFR (median (IQR) 49905.7 (22673.5) vs. 25.657.2 (13842.1) ng/ml, p < 0.001) concentrations postoperatively, while sEGFR plasma levels also showed a significant difference during surgery (median (IQR) 32964.5 (14402.5) vs. 25567.0 (13315.4) ng/ml, p = 0.04). IL-10 levels were significantly higher in the propofol group postoperatively (median (IQR) 13.7 (18.5) vs. 14.9 (66.6) pg/ml, p = 0.05). Conclusions: Given the role of EGFR and adhesion molecules on tumour progression and the generation of metastases, the inhibitory effect of propofol observed in this study might prove useful in the future. Further studies in larger populations investigating the effect of anaesthetic agents on these biomarkers are warranted.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134396100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2019.86739
H. El-Sayed, S. Mehanna, Nermine El Maraghy, S. Younes, A. Hassan, Mahmoud M. Sheded, Z. Khedr
Introduction: Hepatitis C virus is a blood-borne infection and one of the major global problems. In Egypt, the prevalence is reported to be the highest. Infection through unsafe medical procedures is considered now the primary cause of infection. The study aims to assess the knowledge, attitude and practice of doctors regarding infection control guidelines in Ismailia governorate. Material and methods: A cross sectional study was conducted on a sample of physicians (355) in Ismailia governorate using a questionnaire to collect data on their knowledge and attitude concerning the control measures related to their years of experiences. Results: Most of the physicians (89.6%) regardless of their years of experience have had contact with blood products. Those who had a history of needle stick injury accounted for 56.3%, with a statistically significant difference as to the highest number being middle career physicians. Concerning knowledge about infection control policies in their hospitals, it was relatively low among all groups. Conclusions: Despite all efforts exerted by the infection control professionals, infections still remain a major unpleasant side effect of health care, often causing harm to patients.. Although Egypt has made great progress in implementing the infection control procedures and policies, there is still a huge problem as the practices of physicians do not really reflect their knowledge and they still do not follow the infection control policies. Education, monitoring, improved availability of resources and disciplinary measures are necessary to improve infection control in health facilities that should be applied to all physicians.
{"title":"Assessment of doctors’ knowledge, attitude and practice for hepatitis C virus infection control guidelines in Egypt","authors":"H. El-Sayed, S. Mehanna, Nermine El Maraghy, S. Younes, A. Hassan, Mahmoud M. Sheded, Z. Khedr","doi":"10.5114/amscd.2019.86739","DOIUrl":"https://doi.org/10.5114/amscd.2019.86739","url":null,"abstract":"Introduction: Hepatitis C virus is a blood-borne infection and one of the major global problems. In Egypt, the prevalence is reported to be the highest. Infection through unsafe medical procedures is considered now the primary cause of infection. The study aims to assess the knowledge, attitude and practice of doctors regarding infection control guidelines in Ismailia governorate. Material and methods: A cross sectional study was conducted on a sample of physicians (355) in Ismailia governorate using a questionnaire to collect data on their knowledge and attitude concerning the control measures related to their years of experiences. Results: Most of the physicians (89.6%) regardless of their years of experience have had contact with blood products. Those who had a history of needle stick injury accounted for 56.3%, with a statistically significant difference as to the highest number being middle career physicians. Concerning knowledge about infection control policies in their hospitals, it was relatively low among all groups. Conclusions: Despite all efforts exerted by the infection control professionals, infections still remain a major unpleasant side effect of health care, often causing harm to patients.. Although Egypt has made great progress in implementing the infection control procedures and policies, there is still a huge problem as the practices of physicians do not really reflect their knowledge and they still do not follow the infection control policies. Education, monitoring, improved availability of resources and disciplinary measures are necessary to improve infection control in health facilities that should be applied to all physicians.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117274180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2020.92722
L. Sułkowski, C. Osuch, Maciej Matyja, A. Matyja
Introduction: Photodynamic therapy is a minimally invasive clinical treatment modality for a variety of premalignant and malignant conditions combining a photosensitizing drug, oxygen and light irradiation. Hematoporphyrin is an organic photosensitizer, which mediates inhibition of endothelial cell proliferation and induces apoptosis. Human serum albumin is an endogenous drug carrier for hematoporphyrin. The present study aimed to investigate the hematoporphyrin binding to human serum albumin, which is its transport protein. Material and methods: The chemical reagents were hematoporphyrin (Hp), human serum albumin (HSA) and bovine serum albumin (BSA). In the experiment two techniques were used: spectrofluorimetry and UV-Vis absorption spectrophotometry. Results: The binding sites for Hp were identified in the tertiary structure of HSA by fluorescence quenching technique. The experiment with BSA delivered additional data on Hp-albumin interactions close to Trp135. The participation of tyrosyl residues apart from tryptophanyl ones was discussed. A decrease of the polarity in the binding sites, testifying to possible hydrogen bonding in the binding sites, was also described. The binding and quenching constants Hp-HSA and Hp-BSA were determined as well as the number of binding sites. Conclusions: Hp locates in subdomain IIA in the tertiary structure of HSA. The location in subdomain I close to Trp135 is also possible. Hp is also able to interact within tyrosyl residues.
{"title":"Hematoporphyrin binding sites on human serum albumin","authors":"L. Sułkowski, C. Osuch, Maciej Matyja, A. Matyja","doi":"10.5114/amscd.2020.92722","DOIUrl":"https://doi.org/10.5114/amscd.2020.92722","url":null,"abstract":"Introduction: Photodynamic therapy is a minimally invasive clinical treatment modality for a variety of premalignant and malignant conditions combining a photosensitizing drug, oxygen and light irradiation. Hematoporphyrin is an organic photosensitizer, which mediates inhibition of endothelial cell proliferation and induces apoptosis. Human serum albumin is an endogenous drug carrier for hematoporphyrin. The present study aimed to investigate the hematoporphyrin binding to human serum albumin, which is its transport protein. Material and methods: The chemical reagents were hematoporphyrin (Hp), human serum albumin (HSA) and bovine serum albumin (BSA). In the experiment two techniques were used: spectrofluorimetry and UV-Vis absorption spectrophotometry. Results: The binding sites for Hp were identified in the tertiary structure of HSA by fluorescence quenching technique. The experiment with BSA delivered additional data on Hp-albumin interactions close to Trp135. The participation of tyrosyl residues apart from tryptophanyl ones was discussed. A decrease of the polarity in the binding sites, testifying to possible hydrogen bonding in the binding sites, was also described. The binding and quenching constants Hp-HSA and Hp-BSA were determined as well as the number of binding sites. Conclusions: Hp locates in subdomain IIA in the tertiary structure of HSA. The location in subdomain I close to Trp135 is also possible. Hp is also able to interact within tyrosyl residues.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115246238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2019.81668
Y. Kayar, M. Ağın
{"title":"The relationship between demographic and anthropometric characteristics and diabetic complications and number of hospitalizations in hospitalized diabetic patients","authors":"Y. Kayar, M. Ağın","doi":"10.5114/AMSCD.2019.81668","DOIUrl":"https://doi.org/10.5114/AMSCD.2019.81668","url":null,"abstract":"","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122503025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.105393
L. Sułkowski, A. Matyja, C. Osuch, Maciej Matyja
Introduction: Hematoporphyrin is a photosensitizer used in photodynamic therapy of various malignant diseases. It is carried to the cancer tissue by serum albumins. Spectrofluorimetric spectra of hematoporphyrin–serum albumin complexes were examined in vitro. Material and methods: The chemicals were: hematoporphyrin, human serum albumin and bovine serum albumin. The spectra were recorded on a Kontron SFM-25 Instrument AG at two excitation wavelengths: λex = 280 nm and λex = 295 nm. The spectra of hematoporphyrin 1.5 × 10 –5 M as well as spectra of complexes of hematoporphyrin–human serum albumin (1.5 × 10–5 M Hp – 1.25 × 10–6 M HSA) and hematoporphyrin–bovine serum albumin (1.5 × 10–5 M Hp – 3.5 × 10–7 M BSA) were recorded repetitively for 8 days and compared to the initial spectrum. Results: Formation of a complex with human serum albumin extends the stability of the hematoporphyrin spectrum. This extension is greater at excitation λex = 295 nm. Different stability of complexes with bovine and human serum albumins most likely does not result from an actual lower stability of bovine serum albumin complexes, but from the fact that dissimilarity in the structure of both albumins enables additional spectroscopic observations within subdomain IB in the bovine serum albumin molecule. Conclusions: Spectrofluorimetric spectra are stable longer when hematoporphyrin forms a complex with human serum albumin. The present data may be important for understanding the mechanism of hematoporphyrin transportation to the target cancer tissue and effectiveness of photodynamic therapy.
简介:血卟啉是一种光敏剂，用于各种恶性疾病的光动力治疗。它通过血清白蛋白携带到癌组织。体外测定血卟啉-血清白蛋白复合物的荧光光谱。材料与方法:化学成分为血卟啉、人血清白蛋白和牛血清白蛋白。在Kontron SFM-25仪器AG上记录了λex = 280 nm和λex = 295 nm两个激发波长下的光谱。重复记录血卟啉1.5 × 10 - 5 M的光谱，血卟啉-人血清白蛋白(1.5 × 10 - 5 M Hp - 1.25 × 10 - 6 M HSA)和血卟啉-牛血清白蛋白(1.5 × 10 - 5 M Hp - 3.5 × 10 - 7 M BSA)复合物的光谱，持续8 d，并与初始光谱进行比较。结果:血卟啉与人血清白蛋白形成络合物，提高了血卟啉光谱的稳定性。这种扩展在λex = 295 nm时更大。牛和人血清白蛋白复合物的不同稳定性很可能不是由于牛血清白蛋白复合物的实际稳定性较低，而是由于两种白蛋白结构的不同使得在牛血清白蛋白分子的IB亚结构域内进行额外的光谱观察成为可能。结论:血卟啉与人血清白蛋白形成络合物时，荧光光谱稳定性较长。目前的数据可能对了解血卟啉转运到靶癌组织的机制和光动力治疗的有效性具有重要意义。
{"title":"Stability of spectrofluorimetric spectra \u0000of hematoporphyrin–serum albumin complexes: \u0000in vitro study","authors":"L. Sułkowski, A. Matyja, C. Osuch, Maciej Matyja","doi":"10.5114/AMSCD.2021.105393","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.105393","url":null,"abstract":"Introduction: Hematoporphyrin is a photosensitizer used in photodynamic therapy of various malignant diseases. It is carried to the cancer tissue by serum albumins. Spectrofluorimetric spectra of hematoporphyrin–serum albumin complexes were examined in vitro. Material and methods: The chemicals were: hematoporphyrin, human serum albumin and bovine serum albumin. The spectra were recorded on a Kontron SFM-25 Instrument AG at two excitation wavelengths: λex = 280 nm and λex = 295 nm. The spectra of hematoporphyrin 1.5 × 10 –5 M as well as spectra of complexes of hematoporphyrin–human serum albumin (1.5 × 10–5 M Hp – 1.25 × 10–6 M HSA) and hematoporphyrin–bovine serum albumin (1.5 × 10–5 M Hp – 3.5 × 10–7 M BSA) were recorded repetitively for 8 days and compared to the initial spectrum. Results: Formation of a complex with human serum albumin extends the stability of the hematoporphyrin spectrum. This extension is greater at excitation λex = 295 nm. Different stability of complexes with bovine and human serum albumins most likely does not result from an actual lower stability of bovine serum albumin complexes, but from the fact that dissimilarity in the structure of both albumins enables additional spectroscopic observations within subdomain IB in the bovine serum albumin molecule. Conclusions: Spectrofluorimetric spectra are stable longer when hematoporphyrin forms a complex with human serum albumin. The present data may be important for understanding the mechanism of hematoporphyrin transportation to the target cancer tissue and effectiveness of photodynamic therapy.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128166888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2019.86814
R. Yamout, W. Ammar, Jiana Tabbara, Souha Fares, Moubadda Assi, A. Sibai
recruited a Using receiver operating characteristics curve analy-ses, we evaluated different waist circumference cutoff points for the optimal combination of sensitivity and specificity that distinguish men and women with concomitant presence of impaired blood sugar and hypertension. Results: The optimal waist circumference cutoffs for prediction of the outcome were 98.5 cm in men and 91.5 cm in women, yielding better predictive characteristics than those recommended by the International Diabetes Federation (IDF). Based on the study values, the prevalence rates of central obesity in our sample (36.2% in males and 40.2% in females) were lower than those estimated using the IDF cutoff values (55.2% and 79.7%, respec-tively). Conclusions: Findings from this first examination of optimal central obesity cutoff points in Lebanon confirm the need for nation-wide studies with more inclusive cardio-metabolic outcomes for the development of appropriate screening protocols.
{"title":"Waist circumference cutoff points for predicting metabolic abnormalities in Lebanese adults","authors":"R. Yamout, W. Ammar, Jiana Tabbara, Souha Fares, Moubadda Assi, A. Sibai","doi":"10.5114/AMSCD.2019.86814","DOIUrl":"https://doi.org/10.5114/AMSCD.2019.86814","url":null,"abstract":"recruited a Using receiver operating characteristics curve analy-ses, we evaluated different waist circumference cutoff points for the optimal combination of sensitivity and specificity that distinguish men and women with concomitant presence of impaired blood sugar and hypertension. Results: The optimal waist circumference cutoffs for prediction of the outcome were 98.5 cm in men and 91.5 cm in women, yielding better predictive characteristics than those recommended by the International Diabetes Federation (IDF). Based on the study values, the prevalence rates of central obesity in our sample (36.2% in males and 40.2% in females) were lower than those estimated using the IDF cutoff values (55.2% and 79.7%, respec-tively). Conclusions: Findings from this first examination of optimal central obesity cutoff points in Lebanon confirm the need for nation-wide studies with more inclusive cardio-metabolic outcomes for the development of appropriate screening protocols.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129204805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.105843
P. Atencio, Rosa Arboiro-Pinel, A. Cabello, F. Conesa-Buendía, M. Górgolas, A. Mediero, M. Díaz-Curiel
Results: The mean age was 33.11 ±6.6 years, and they were 56.4% Caucasian and 43.6% Latin American. Regarding lifestyle and risk factors, 57% had previous exposure to tobacco and 31% reported drug use. Low BMD ( Z -score < –2.0) was found in 21.4% of the patients, and partially degraded and degraded in 25% and 1.7%, respectively in TBS. We find significative prevalence of bone involvement among naïve HIV-infected men under 50 years old. Conclusions: Further studies are necessary to evaluate if BMD assessment should be recommended in young HIV-infected patients.
{"title":"Trabecular bone score and 3D-DXA in young, antiretroviral treatment-naïve patients in Madrid","authors":"P. Atencio, Rosa Arboiro-Pinel, A. Cabello, F. Conesa-Buendía, M. Górgolas, A. Mediero, M. Díaz-Curiel","doi":"10.5114/AMSCD.2021.105843","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.105843","url":null,"abstract":"Results: The mean age was 33.11 ±6.6 years, and they were 56.4% Caucasian and 43.6% Latin American. Regarding lifestyle and risk factors, 57% had previous exposure to tobacco and 31% reported drug use. Low BMD ( Z -score < –2.0) was found in 21.4% of the patients, and partially degraded and degraded in 25% and 1.7%, respectively in TBS. We find significative prevalence of bone involvement among naïve HIV-infected men under 50 years old. Conclusions: Further studies are necessary to evaluate if BMD assessment should be recommended in young HIV-infected patients.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"2008 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125578484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/amscd.2022.121209
Ahmed Faisal Kareem Alkaabi, E. Caylak, Yasar Yazgan, Ali Al-Jubooir
higher compared with that among the administrative employees (21.42 ±3.64); this difference was statistically significant between the groups ( p = 0.036). Conclusions: Improving work conditions could decrease the stress felt by emergency nurses. It is necessary to improve the conditions and to reduce the duration of nurses’ work, to increase the number of nurses in emergency departments, to institutionalize the nursing profession, to pay attention to specialized education, and to improve economic conditions.
{"title":"Assessment of psychological stress in emergency nurses: a descriptive study","authors":"Ahmed Faisal Kareem Alkaabi, E. Caylak, Yasar Yazgan, Ali Al-Jubooir","doi":"10.5114/amscd.2022.121209","DOIUrl":"https://doi.org/10.5114/amscd.2022.121209","url":null,"abstract":"higher compared with that among the administrative employees (21.42 ±3.64); this difference was statistically significant between the groups ( p = 0.036). Conclusions: Improving work conditions could decrease the stress felt by emergency nurses. It is necessary to improve the conditions and to reduce the duration of nurses’ work, to increase the number of nurses in emergency departments, to institutionalize the nursing profession, to pay attention to specialized education, and to improve economic conditions.","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"267 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123107971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2021.107850
Rona Kartika, I. Alwi, E. Yunir, S. Waspadji, F. Suyatna, S. Immanuel, S. Sungkar, J. Rachmat, M. Reksodiputro, T. Silalahi, S. Bardosono
{"title":"Comparison of cotton swab to Whatman cellulose paper as media for examination of biomarkers from diabetic ulcers","authors":"Rona Kartika, I. Alwi, E. Yunir, S. Waspadji, F. Suyatna, S. Immanuel, S. Sungkar, J. Rachmat, M. Reksodiputro, T. Silalahi, S. Bardosono","doi":"10.5114/AMSCD.2021.107850","DOIUrl":"https://doi.org/10.5114/AMSCD.2021.107850","url":null,"abstract":"","PeriodicalId":169652,"journal":{"name":"Archives of Medical Science - Civilization Diseases","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115018844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.5114/AMSCD.2019.85654
C. Turkler, T. Kiremitli
Introduction: This study primarily aimed to investigate the associations between unclassified HPV genotypes and cervical lesions. Material and methods: This was a retrospective review of 411 patients with HPV positivity. The participants were divided into two groups: Group X contained HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 while group Y contained unclassified HPV genotypes such as 42, 54, 61, 62, 71, 81, 83, 84 and 89. The X and Y groups were compared in terms of demographic characteristics and related cervical pathologies. We investigated the potential of HPV genotypes in group Y to develop cervical neoplasia. Results: HPV 16 is the most common genotype in group X (28.5%) whereas HPV 83 is the most common genotype in group Y (4.9%). Group X and group Y were statistically similar with respect to age (p = 0.231), parity (p = 0.617), occupation (p = 0.535), marital status (p = 0.644), education level (p = 0.316), smoking (p = 0.352), gynecological findings (p = 0.201), Pap smear results (p = 0.427), and colposcopy findings (p = 0.476). When compared to group X, normal cervical biopsy was significantly more frequent (18.6% vs. 39.1%), chronic cervicitis was significantly less frequent (49.5% vs. 36.9%), CIN 1 was significantly less frequent (12.9% vs. 8.7%) and CIN 2 was significantly less frequent (5.6% vs. 2.2%) (p = 0.012). Cervical cancer was diagnosed in three patients of group X and one patient of group Y (1.6% vs. 2.2%). Conclusions: Screening programs for cervical cancer are generally performed to detect HPV genotypes with high oncogenic potential. The importance of unclassified HPV genotypes should be investigated in large scale studies so that the success of screening programs and vaccination can be improved.
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