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Improving geographic access to methadone clinics 改善美沙酮诊所的地理可及性
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108836
Anthony Bonifonte , Erin Garcia

Introduction

Opioid misuse is a nationwide public health crisis. Methadone treatment is proven to be highly successful in preventing opioid use disorder, reducing the use of illicit drugs, and preventing overdoses. Clients acquire methadone daily from clinics, making geographic access crucial for the initiation of and adherence to treatment.

Methods

This work estimates unsatisfied methadone demand due to lack of geographic access at a census tract level and models the problem of identifying optimal locations to open new methadone clinics. The objective function of the model is a weighted combination of providing access to individuals with unmet methadone demand and improving the travel time of individuals currently attending a clinic. Data on existing methadone clinics and statewide methadone demand is acquired from Substance Abuse and Mental Health Services Administration (SAMHSA) surveys from 2019. Unsatisfied demand is estimated through a linear regression model after aggregating the population, heroin use, and satisfied methadone demand at the state level.

Results

Nationwide, we find 18.2 % of the United States population does not have geographic access to a methadone clinic and estimate 77,973 individuals in these areas would attend a clinic if geographic access barriers were removed (95 % CI: 67,413–88,532). In a case study of six Midwestern states, we find that geography significantly contributes to the value of opening additional clinics and we see large differences in expected gains between states sharing similar characteristics such as population and satisfied methadone demand. The number of additional clients served by opening one new clinic ranges from 180 to 804 across these six states, representing between 8.4 % and 16.2 % of state unmet demand. Between 1.2 % and 14.1 % of existing clients were reassigned with a single newly opened clinic, with a one-way average travel distance improvement between 6.3 and 11.9 miles / person / day for these clients.

Conclusions

The results demonstrate the large unserved methadone demand in the United States, the significant improvement in methadone access for new and existing clients that can be achieved by opening new clinics, and the important role state-specific geography plays in these decisions.

阿片类药物滥用是一个全国性的公共卫生危机。事实证明,美沙酮治疗在预防阿片类药物使用障碍、减少非法药物使用和预防过量使用方面非常成功。客户每天从诊所获得美沙酮,使得地理上的可及性对于开始和坚持治疗至关重要。方法本研究估计了由于人口普查区缺乏地理通道而导致的未满足的美沙酮需求,并对确定开设新美沙酮诊所的最佳地点的问题进行了建模。该模型的目标函数是为未满足美沙酮需求的个体提供途径和改善当前就诊个体的出行时间的加权组合。现有美沙酮诊所和全州美沙酮需求的数据来自2019年以来物质滥用和精神卫生服务管理局(SAMHSA)的调查。在汇总人口、海洛因使用情况和州一级已满足的美沙酮需求后,通过线性回归模型估计未满足的需求。结果在全国范围内,我们发现18.2%的美国人口没有地理上的美沙酮诊所,如果地理上的障碍被消除,估计这些地区的77,973人会去诊所就诊(95% CI: 67,413-88,532)。在对中西部六个州的案例研究中,我们发现地理位置对开设额外诊所的价值有很大贡献,我们看到在人口和满足美沙酮需求等特征相似的州之间,预期收益存在很大差异。在这六个州,开设一家新诊所所服务的额外客户数量从180到804不等,占州未满足需求的8.4%到16.2%。1.2%至14.1%的现有客户被重新分配到一家新开的诊所,这些客户的单程平均旅行距离在6.3至11.9英里/人/天之间。结论:研究结果表明,美国存在大量未服务的美沙酮需求,通过开设新诊所可以显著改善新老客户的美沙酮可及性,并且各州具体地理因素在这些决策中起着重要作用。
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引用次数: 1
Research to law: A qualitative study of Massachusetts' 2018 Care Act expanding emergency department initiation of medication for opioid use disorder 法律研究:对马萨诸塞州2018年《护理法》的定性研究,该法案扩大了急诊科对阿片类药物使用障碍药物的使用。
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108803
Rachel H. Alinsky , Catherine Silva , Hoover Adger , Emma E. McGinty

Background

Initiating medication for opioid use disorder (MOUD) during emergency department (ED) visits is an important innovation to engage individuals in addiction treatment. In 2018, Massachusetts passed the CARE Act, becoming the first state to legislate that hospitals with EDs must be able to offer MOUD. We performed a qualitative study to explore factors influencing policy enactment.

Methods

Semi-structured interviews were conducted in 2019 with ten key stakeholders involved in the policymaking process representing state government, hospitals, physician professional societies, and recovery/behavioral health organizations. Data were analyzed in 2020–2021 using a hybrid inductive-deductive approach.

Results

The first key theme stakeholders expressed was the importance of research and public health consensus; they described consensus building within existing coalitions regarding the pressing need for action, and supporting expansion of treatment with this evidence-based strategy. Second, stakeholders discussed overcoming financing and feasibility concerns by passing budget-neutral legislation and ensuring flexibility for diverse hospital types. Lastly, stakeholders looked towards implementation, describing the implementation guide development process and ensuring capacity for continuing treatment existed throughout the state.

Conclusions

This study suggests that research supporting the effectiveness of ED MOUD induction drove the passage of this state legislation. Long-term collaboration between diverse stakeholders towards a common goal of increasing access to evidence-based treatment to address the opioid epidemic was also perceived as facilitating the law's passage. Policymakers and advocates in other states may look towards Massachusetts's legislative process as a model for implementing similar legislation as part of their strategies to address the drug overdose crisis.

背景:在急诊科(ED)就诊时启动阿片类药物使用障碍(mod)的药物治疗是一项重要的创新,可以让个体参与成瘾治疗。2018年,马萨诸塞州通过了《护理法案》(CARE Act),成为第一个立法规定拥有急诊科的医院必须能够提供mod的州。本研究以质性研究探讨政策制定的影响因素。方法在2019年对州政府、医院、医师专业协会和康复/行为健康组织等参与决策过程的10个关键利益相关者进行了半结构化访谈。使用混合归纳-演绎方法分析2020-2021年的数据。结果利益相关者表达的第一个关键主题是研究和公共卫生共识的重要性;他们描述了在现有联盟内就迫切需要采取行动达成的共识,并支持利用这一循证战略扩大治疗。第二,利益相关者讨论了通过预算中立立法和确保不同类型医院的灵活性来克服融资和可行性问题。最后,利益相关者展望了实施,描述了实施指南的发展过程,并确保在整个州存在持续治疗的能力。结论本研究表明,支持ED诱导的有效性的研究推动了国家立法的通过。与会者还认为,各利益攸关方之间为实现增加获得循证治疗以应对类阿片流行病这一共同目标而开展的长期合作有助于促进该法律的通过。其他州的政策制定者和倡导者可能会将马萨诸塞州的立法程序视为实施类似立法的典范,作为解决药物过量危机战略的一部分。
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引用次数: 0
Factors associated with clinician treatment recommendations for patients with a new diagnosis of opioid use disorder 与临床医生对阿片类药物使用障碍新诊断患者的治疗建议相关的因素
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108827
Lewei (Allison) Lin , Victoria D. Powell , Colin Macleod , Amy S.B. Bohnert , Pooja Lagisetty

Background

This study examined factors associated with treatment recommendations for patients with a new diagnosis of opioid use disorder (OUD), comparing recommendations for patients with clear signs of OUD versus those with lower likelihood of OUD.

Methods

The study conducted a retrospective medical chart review in a randomly selected national sample of 520 Veteran Health Administration patients with a new opioid-related electronic health record (EHR) diagnosis from 2012 to 2017. The study categorized patients as having “high likelihood” or “lower likelihood of OUD” based on the presence or absence of clinician documentation in medical records of specific qualifying criteria (e.g., clinician documentation of patient meeting diagnostic criteria for OUD, etc). Analyses examined the association between baseline demographic and clinical characteristics with recommendations for medication and other treatments for OUD.

Results

Among patients with a new diagnosis of OUD, 28.7 % (n = 149) were recommended medication treatment, 52.5 % (n = 273) were recommended specialty substance use disorder (SUD) treatment, and 41.9 % (n = 218) were recommended treatment in non-SUD mental health settings. In adjusted models, high likelihood of OUD (AOR 8.31, 95 % CI 4.81–15.03) was strongly associated with the clinician recommending medications for OUD, while age 56–75 (compared to <35, AOR 0.36, 95 % CI 0.18–0.69), stimulant use disorder (AOR 0.28, 95 % CI 0.15–0.53), and rural residence (AOR 0.51, 95 % CI 0.30–0.85) were associated with lower likelihood of being recommended medication treatment.

Conclusions

Differentiating among patients with EHR diagnoses of OUD to identify the subset with higher likelihood of underlying OUD is important to accurately understand OUD treatment rates and disparities. However, even among patients with a clear diagnosis of OUD, medication treatment is still recommended less often than other treatments, suggesting interventions are needed to encourage clinicians to prioritize medication treatment as a first-line treatment, especially for older, rural patients and those with polysubstance use.

本研究考察了与阿片类药物使用障碍(OUD)新诊断患者的治疗建议相关的因素,比较了有明显OUD迹象的患者和发生OUD可能性较低的患者的建议。方法对2012年至2017年全国随机抽取520例阿片类药物相关电子健康记录(EHR)新诊断的退伍军人卫生管理局患者进行回顾性病历回顾。该研究将患者分为“高可能性”或“低可能性”,基于医疗记录中是否存在特定资格标准的临床医生文件(例如,临床医生文件证明患者符合OUD的诊断标准等)。分析检查了基线人口统计学和临床特征与OUD药物治疗和其他治疗建议之间的关系。结果在新诊断为OUD的患者中,28.7% (n = 149)推荐药物治疗,52.5% (n = 273)推荐特殊物质使用障碍(SUD)治疗,41.9% (n = 218)推荐非SUD精神卫生机构治疗。在调整后的模型中,患OUD的高可能性(AOR 8.31, 95% CI 4.81-15.03)与临床医生推荐OUD药物的可能性密切相关,而56-75岁(与35岁相比,AOR 0.36, 95% CI 0.18-0.69)、兴奋剂使用障碍(AOR 0.28, 95% CI 0.15-0.53)和农村居住(AOR 0.51, 95% CI 0.30-0.85)与推荐药物治疗的可能性较低相关。结论在EHR诊断为OUD的患者中进行区分,以确定潜在OUD可能性较高的亚群,对于准确了解OUD治疗率和差异具有重要意义。然而,即使在明确诊断为OUD的患者中,药物治疗的推荐率仍然低于其他治疗方法,这表明需要采取干预措施,鼓励临床医生优先考虑药物治疗作为一线治疗,特别是对于老年人,农村患者和多物质使用患者。
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引用次数: 2
Emergency department interventions for opioid use disorder: A synthesis of emerging models 急诊部门对阿片类药物使用障碍的干预:新兴模型的综合
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108837
Cindy Parks Thomas , Maureen T. Stewart , Cynthia Tschampl , Kumba Sennaar , Daniel Schwartz , Judith Dey

Introduction

Opioid overdose deaths are increasing, and improving access to evidence-based treatment is necessary. Emergency department (ED) initiation of treatment for opioid use disorder (OUD) via medications and referral to treatment is one approach that leverages a critical health care entry point for individuals with OUD. Efforts to engage patients in treatment through the ED are growing, but systematic analysis of program features as implemented and challenges across different models remains limited. Lessons from early adopter programs may benefit clinicians and others looking to offer ED-initiated treatment for OUD.

Methods

We conducted case studies of five ED-based efforts to address OUD across the United States, selected for diversity in structure, approach, and geography. We conducted telephone interviews with 37 individuals (ED physicians, ED nurses, navigators, hospital administrators, community providers, and state policymakers) affiliated with the five programs. Interviews were transcribed, coded, and analyzed using a framework analysis approach, identifying relevant lessons for replication.

Results

These five programs (an academic medical center, two large urban hospitals, a rural community hospital, and a community-based program) successfully implemented ED-initiated MOUD. Often a champion with knowledge of OUD treatment and a reliable connection with outpatient treatment began the program. The approach to patient identification varied from universal screening to relying on patient self-identification. Substance use treatment navigators provide crucial services but can be difficult to pay for within current reimbursement frameworks. Barriers to implementation include lack of knowledge about treatment options and effectiveness, stigma, community treatment capacity limits, and health insurance and reimbursement policies. Facilitators of success include taking a patient-centered, low-barrier approach, having a passionate champion, a strong structure with health system support, and a relationship with community partners. Metrics for success vary across programs. Some programs are expanding to include treating the use of other substances such as alcohol and stimulants.

Conclusion

ED-initiated MOUD is feasible across different settings. Research and real world efforts need to promote programs that include OUD treatment as standard in ED treatment.

阿片类药物过量死亡正在增加,有必要改善获得循证治疗的机会。急诊科(ED)通过药物治疗和转诊治疗开始治疗阿片类药物使用障碍(OUD)是一种利用OUD患者关键卫生保健切入点的方法。通过急诊科让患者参与治疗的努力正在增加,但对不同模式下实施的项目特征和挑战的系统分析仍然有限。早期应用项目的经验教训可能会使临床医生和其他希望为OUD提供ed启动治疗的人受益。方法:我们对美国五个以教育为基础的解决OUD的努力进行了案例研究,选择了结构、方法和地理上的多样性。我们对与五个项目相关的37个人(急诊科医生、急诊科护士、导航员、医院管理人员、社区提供者和州决策者)进行了电话采访。对访谈进行转录、编码,并使用框架分析方法进行分析,确定可复制的相关经验教训。结果5个项目(1个学术性医疗中心、2个大型城市医院、1个农村社区医院和1个社区项目)成功实施了ed启动模式。通常是一个对OUD治疗有了解并且与门诊治疗有可靠联系的冠军开始这个项目。患者鉴定的方法从普遍筛查到依赖患者自我鉴定各不相同。药物使用治疗导航员提供至关重要的服务,但在目前的报销框架内可能难以支付。实施的障碍包括缺乏关于治疗选择和有效性的知识、耻辱、社区治疗能力限制以及健康保险和报销政策。促进成功的因素包括采取以患者为中心的低障碍方法,拥有热情的拥护者,具有卫生系统支持的强大结构以及与社区合作伙伴的关系。衡量成功的标准因项目而异。一些项目正在扩大,包括治疗酒精和兴奋剂等其他物质的使用。结论启动模式在不同的环境下都是可行的。研究和现实世界的努力需要促进将OUD治疗作为ED治疗的标准方案。
{"title":"Emergency department interventions for opioid use disorder: A synthesis of emerging models","authors":"Cindy Parks Thomas ,&nbsp;Maureen T. Stewart ,&nbsp;Cynthia Tschampl ,&nbsp;Kumba Sennaar ,&nbsp;Daniel Schwartz ,&nbsp;Judith Dey","doi":"10.1016/j.jsat.2022.108837","DOIUrl":"10.1016/j.jsat.2022.108837","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Opioid overdose deaths are increasing, and improving access to evidence-based treatment is necessary. </span>Emergency department<span> (ED) initiation of treatment for opioid use disorder (OUD) via medications and referral to treatment is one approach that leverages a critical health care entry point for individuals with OUD. Efforts to engage patients in treatment through the ED are growing, but systematic analysis of program features as implemented and challenges across different models remains limited. Lessons from early adopter programs may benefit clinicians and others looking to offer ED-initiated treatment for OUD.</span></p></div><div><h3>Methods</h3><p>We conducted case studies of five ED-based efforts to address OUD across the United States, selected for diversity in structure, approach, and geography. We conducted telephone interviews with 37 individuals (ED physicians, ED nurses, navigators, hospital administrators, community providers, and state policymakers) affiliated with the five programs. Interviews were transcribed, coded, and analyzed using a framework analysis approach, identifying relevant lessons for replication.</p></div><div><h3>Results</h3><p>These five programs (an academic medical center, two large urban hospitals, a rural community hospital, and a community-based program) successfully implemented ED-initiated MOUD. Often a champion with knowledge of OUD treatment and a reliable connection with outpatient treatment began the program. The approach to patient identification varied from universal screening to relying on patient self-identification. Substance use treatment navigators provide crucial services but can be difficult to pay for within current reimbursement frameworks. Barriers to implementation include lack of knowledge about treatment options and effectiveness, stigma, community treatment capacity limits, and health insurance and reimbursement policies. Facilitators of success include taking a patient-centered, low-barrier approach, having a passionate champion, a strong structure with health system<span> support, and a relationship with community partners. Metrics for success vary across programs. Some programs are expanding to include treating the use of other substances such as alcohol and stimulants.</span></p></div><div><h3>Conclusion</h3><p>ED-initiated MOUD is feasible across different settings. Research and real world efforts need to promote programs that include OUD treatment as standard in ED treatment.</p></div>","PeriodicalId":17148,"journal":{"name":"Journal of Substance Abuse Treatment","volume":"141 ","pages":"Article 108837"},"PeriodicalIF":3.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40510544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Predictors of engagement and retention in care at a low-threshold substance use disorder bridge clinic 低阈值物质使用障碍桥诊所护理参与和保留的预测因素
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108848
Sarah E. Wakeman , Sydney McGovern , Laura Kehoe , Martha T. Kane , Elizabeth A. Powell , Sarah K. Casey , Giovanie M. Yacorps , Jasmine R. Irvin , Windia Rodriguez , Susan Regan

Introduction

People with substance user disorder (SUD) have frequent intersections with the health care system; however, engagement and retention in SUD care remain low, particularly for marginalized populations. Low-threshold treatment models that aim to eliminate barriers to care are one proposed intervention to increase access and equity in SUD treatment.

Methods

This is a retrospective, cohort study of patients treated at a low-threshold bridge clinic from 2016 to 2021. The study's primary aim was to describe patient characteristics associated with engagement, defined as two or more completed visits, and treatment retention at 60 days, defined as a completed visit 45-to-75 days after first visit. A secondary outcome was transfer to ongoing treatment after bridge clinic. The study analyzed multivariable models assessing demographic and clinical predictors for each outcome using generalized estimating equations.

Results

The study found that 1857 patients completed 2730 care episodes. The mean age was 38.7 years old, 70 % were male, 30 % female, 79 % White, 7 % Black, 9 % Latinx, and 97 % spoke English. Opioid use disorder (OUD) was the most common type of SUD, seen among 84 % of episodes, followed by alcohol (30 %), and stimulant use disorder (28 %). Seventy percent of bridge clinic episodes of care resulted in engagement, 38 % were retained at 60 days, and 28 % had transfer to care documented. In adjusted analyses, engagement was lower for Black patients compared to White patients and higher for patients who received buprenorphine or naltrexone. Retention for Black patients was also lower compared to White patients and higher for patients who were unhoused and patients who received buprenorphine or naltrexone. Transfer of care was more likely among patients who received buprenorphine.

Conclusions

At a low-threshold bridge clinic 70 % of patients successfully engaged in care and 38 % were retained at two months. While OUD and AUD were most prevalent, stimulant use was common in this population. Patients who received buprenorphine or naltrexone had higher engagement, and retention, and those receiving buprenorphine also had higher care transfer. Black patients had lower rates of engagement and retention. Treatment providers need to adopt low-threshold SUD care models to eliminate racial disparities and address the needs of people using stimulants.

物质使用障碍(SUD)患者与卫生保健系统有频繁的交集;然而,对SUD护理的参与和保留仍然很低,特别是对边缘化人群。旨在消除护理障碍的低阈值治疗模式是增加SUD治疗可及性和公平性的一种建议干预措施。方法本研究是一项回顾性队列研究,研究对象为2016年至2021年在低门槛桥诊所接受治疗的患者。该研究的主要目的是描述与参与相关的患者特征,定义为两次或两次以上的完整就诊,以及60天内的治疗保留,定义为首次就诊后45- 75天的完整就诊。第二个结果是在桥诊所后转入持续治疗。该研究分析了使用广义估计方程评估每种结果的人口统计学和临床预测因素的多变量模型。结果1857例患者共完成2730次护理。平均年龄为38.7岁,70%为男性,30%为女性,79%为白人,7%为黑人,9%为拉丁裔,97%为英语。阿片类药物使用障碍(OUD)是最常见的SUD类型,在84%的发作中出现,其次是酒精(30%)和兴奋剂使用障碍(28%)。70%的桥式临床护理事件导致参与,38%在60天保留,28%转移到有记录的护理。在调整分析中,与白人患者相比,黑人患者的参与度较低,而接受丁丙诺啡或纳曲酮治疗的患者参与度较高。黑人患者的保留率也低于白人患者,而无家可归的患者和接受丁丙诺啡或纳曲酮治疗的患者保留率更高。接受丁丙诺啡治疗的患者更有可能转移治疗。结论在低阈桥诊所,70%的患者成功进行了护理,38%的患者在两个月后保留。虽然OUD和AUD最普遍,但兴奋剂的使用在这一人群中很常见。接受丁丙诺啡或纳曲酮治疗的患者有更高的敬业度和保留率,接受丁丙诺啡治疗的患者也有更高的护理转移。黑人患者的参与率和保留率较低。治疗提供者需要采用低阈值的SUD护理模式,以消除种族差异,满足兴奋剂使用者的需求。
{"title":"Predictors of engagement and retention in care at a low-threshold substance use disorder bridge clinic","authors":"Sarah E. Wakeman ,&nbsp;Sydney McGovern ,&nbsp;Laura Kehoe ,&nbsp;Martha T. Kane ,&nbsp;Elizabeth A. Powell ,&nbsp;Sarah K. Casey ,&nbsp;Giovanie M. Yacorps ,&nbsp;Jasmine R. Irvin ,&nbsp;Windia Rodriguez ,&nbsp;Susan Regan","doi":"10.1016/j.jsat.2022.108848","DOIUrl":"10.1016/j.jsat.2022.108848","url":null,"abstract":"<div><h3>Introduction</h3><p><span>People with substance user disorder (SUD) have frequent intersections with the health care system; however, engagement and retention in SUD care remain low, particularly for </span>marginalized populations<span>. Low-threshold treatment models that aim to eliminate barriers to care are one proposed intervention to increase access and equity in SUD treatment.</span></p></div><div><h3>Methods</h3><p>This is a retrospective, cohort study of patients treated at a low-threshold bridge clinic from 2016 to 2021. The study's primary aim was to describe patient characteristics associated with engagement, defined as two or more completed visits, and treatment retention at 60 days, defined as a completed visit 45-to-75 days after first visit. A secondary outcome was transfer to ongoing treatment after bridge clinic. The study analyzed multivariable models assessing demographic and clinical predictors for each outcome using generalized estimating equations.</p></div><div><h3>Results</h3><p><span><span>The study found that 1857 patients completed 2730 care episodes. The mean age was 38.7 years old, 70 % were male, 30 % female, 79 % White, 7 % Black, 9 % Latinx, and 97 % spoke English. Opioid use disorder (OUD) was the most common type of SUD, seen among 84 % of episodes, followed by alcohol (30 %), and stimulant use disorder (28 %). Seventy percent of bridge clinic episodes of care resulted in engagement, 38 % were retained at 60 days, and 28 % had transfer to care documented. In adjusted analyses, engagement was lower for Black patients compared to White patients and higher for patients who received </span>buprenorphine or </span>naltrexone. Retention for Black patients was also lower compared to White patients and higher for patients who were unhoused and patients who received buprenorphine or naltrexone. Transfer of care was more likely among patients who received buprenorphine.</p></div><div><h3>Conclusions</h3><p>At a low-threshold bridge clinic 70 % of patients successfully engaged in care and 38 % were retained at two months. While OUD and AUD<span> were most prevalent, stimulant use was common in this population. Patients who received buprenorphine or naltrexone had higher engagement, and retention, and those receiving buprenorphine also had higher care transfer. Black patients had lower rates of engagement and retention. Treatment providers need to adopt low-threshold SUD care models to eliminate racial disparities and address the needs of people using stimulants.</span></p></div>","PeriodicalId":17148,"journal":{"name":"Journal of Substance Abuse Treatment","volume":"141 ","pages":"Article 108848"},"PeriodicalIF":3.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40600908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can nicotine replacement therapy be personalized? A statistical learning analysis 尼古丁替代疗法可以个性化吗?统计学习分析
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108847
Scott Veldhuizen , Laurie Zawertailo , Sarwar Hussain , Sabrina Voci , Peter Selby

Background

Technology has made automated care personalization practical, but useful personalization requires information about systematic differences between individuals in the effectiveness of different interventions. Here, we used observational data to search for differences in smoking cessation treatment outcomes associated with interactions between participant characteristics and different types and doses of nicotine replacement therapy (NRT).

Methods

We analyzed 33,077 enrollments in a large primary care smoking cessation program in Ontario, Canada. We considered 10 types and combinations of NRT, as well as the provided daily dose of nicotine. We used ridge regression to fit one main effects model and one model including all possible interactions between these measures and a range of demographic and health variables. We then compared the predictive accuracy of these models in a held-out 25 % testing subset using areas under the receiver operating characteristic curve (AUROC) and the integrated discrimination improvement index (IDI). We used random forest multiple imputation to address missing data.

Results

The model including main effects only modestly predicted quit success at 6 months (AUROC = 0.646, 95 % CI = 0.631, 0.660). The final model with all interactions had essentially identical performance (AUROC = 0.640, 95 % CI = 0.626, 0.654; IDI = −0.0066).

Conclusion

We found no evidence of meaningful interactions between treatment outcomes and participants' characteristics, NRT type, or NRT dose. Although data are observational, these findings suggest that the effectiveness of different types and doses of NRT do not vary substantially with participant characteristics. Personalization based on the overall likelihood of quit success, or using genetic or other biological data, remains possible.

技术已经使自动化护理个性化成为现实,但有用的个性化需要关于不同干预措施有效性的个体之间系统差异的信息。在这里,我们使用观察性数据来寻找与参与者特征和不同类型和剂量的尼古丁替代疗法(NRT)之间相互作用相关的戒烟治疗结果的差异。方法:我们分析了加拿大安大略省一个大型初级保健戒烟项目的33,077名登记患者。我们考虑了10种NRT的类型和组合,以及提供的每日尼古丁剂量。我们使用脊回归来拟合一个主效应模型和一个包括这些措施与一系列人口和健康变量之间所有可能相互作用的模型。然后,我们使用受试者工作特征曲线下面积(AUROC)和综合判别改善指数(IDI)比较了这些模型在25%测试子集中的预测准确性。我们使用随机森林多重插值来解决缺失数据。结果包含主效应的模型仅能适度预测6个月戒烟成功(AUROC = 0.646, 95% CI = 0.631, 0.660)。所有相互作用的最终模型的性能基本相同(AUROC = 0.640, 95% CI = 0.626, 0.654;idi =−0.0066)。结论:我们没有发现治疗结果与受试者特征、NRT类型或NRT剂量之间有意义的相互作用的证据。虽然数据是观察性的,但这些发现表明,不同类型和剂量的NRT的有效性并不因参与者的特征而有很大差异。基于戒烟成功的总体可能性,或使用基因或其他生物学数据的个性化仍然是可能的。
{"title":"Can nicotine replacement therapy be personalized? A statistical learning analysis","authors":"Scott Veldhuizen ,&nbsp;Laurie Zawertailo ,&nbsp;Sarwar Hussain ,&nbsp;Sabrina Voci ,&nbsp;Peter Selby","doi":"10.1016/j.jsat.2022.108847","DOIUrl":"10.1016/j.jsat.2022.108847","url":null,"abstract":"<div><h3>Background</h3><p>Technology has made automated care personalization practical, but useful personalization requires information about systematic differences between individuals in the effectiveness of different interventions. Here, we used observational data to search for differences in smoking cessation<span><span> treatment outcomes associated with interactions between participant characteristics and different types and doses of </span>nicotine replacement therapy (NRT).</span></p></div><div><h3>Methods</h3><p><span>We analyzed 33,077 enrollments in a large primary care </span>smoking cessation program in Ontario, Canada. We considered 10 types and combinations of NRT, as well as the provided daily dose of nicotine. We used ridge regression to fit one main effects model and one model including all possible interactions between these measures and a range of demographic and health variables. We then compared the predictive accuracy of these models in a held-out 25 % testing subset using areas under the receiver operating characteristic curve (AUROC) and the integrated discrimination improvement index (IDI). We used random forest multiple imputation to address missing data.</p></div><div><h3>Results</h3><p>The model including main effects only modestly predicted quit success at 6 months (AUROC = 0.646, 95 % CI = 0.631, 0.660). The final model with all interactions had essentially identical performance (AUROC = 0.640, 95 % CI = 0.626, 0.654; IDI = −0.0066).</p></div><div><h3>Conclusion</h3><p>We found no evidence of meaningful interactions between treatment outcomes and participants' characteristics, NRT type, or NRT dose. Although data are observational, these findings suggest that the effectiveness of different types and doses of NRT do not vary substantially with participant characteristics. Personalization based on the overall likelihood of quit success, or using genetic or other biological data, remains possible.</p></div>","PeriodicalId":17148,"journal":{"name":"Journal of Substance Abuse Treatment","volume":"141 ","pages":"Article 108847"},"PeriodicalIF":3.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40600907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment retention, return to use, and recovery support following COVID-19 relaxation of methadone take-home dosing in two rural opioid treatment programs: A mixed methods analysis 两种农村阿片类药物治疗方案中美沙酮带回家剂量放松后的治疗保留、恢复使用和康复支持:混合方法分析
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108801
Kim A. Hoffman , Canyon Foot , Ximena A. Levander , Ryan Cook , Javier Ponce Terashima , John W. McIlveen , P. Todd Korthuis , Dennis McCarty

Objectives

In March 2020, the Substance Abuse and Mental Health Services Administration permitted Opioid Treatment Programs (OTPs) to relax restrictions on take-home methadone and promoted telehealth to minimize potential exposures to COVID-19. We assessed the effects of COVID-19-related changes on take-home methadone dosing in two OTPs serving five rural Oregon counties.

Methods

We used a mixed-methods convergent design. The OTPs extracted urine drug test (UDT) results, take-home methadone regimens, and treatment retention from the electronic health record (EHR) for patients (n = 377). A mixed-effects negative binomial regression model assessed patient-level differences in take-home doses before and after the COVID-19 policy changes and the associations with treatment discontinuation, and UDT positivity. Semi-structured qualitative interviews (n = 32) explored patient reactions to increased take-home dosing and reduced clinic visits to provide context for quantitative findings.

Results

The number of take-home doses increased in the post-COVID-19 period for patients engaged in treatment for more than 180 days (median: 8 vs 13 take-home doses per month, p = 0.011). Take-homes did not increase for patients with fewer days of treatment. Each percentage point increase in take-home dosing above what would be expected without COVID-19 policy changes was negatively associated with the percent of UDT positive for opioids (B = −0.12, CI [−0.21, −0.04], p = 0.005) and the probability of treatment discontinuation (aOR = 0.97, CI [0.95, 0.99], p = 0.003). Qualitative analysis revealed three themes explaining how increased take-home dosing supported recovery: 1) value of feeling trusted with increased responsibility; 2) reduced travel time permitted increased employment and recreation; and 3) reduced exposure to individuals less stable in recovery and potential triggers.

Conclusions

Take-home methadone dose relaxations were associated with increased methadone take-home doses, improved retention, and decreased UDT opioid positive results among clinically stable patients. Qualitative findings suggest that fewer take-home restrictions are feasible and desirable and do not pose safety or public health harms.

2020年3月,美国药物滥用和精神卫生服务管理局允许阿片类药物治疗项目(OTPs)放宽对带回家的美沙酮的限制,并促进远程医疗,以尽量减少对COVID-19的潜在暴露。我们评估了为俄勒冈州五个农村县服务的两个otp中与covid -19相关的变化对美沙酮带回家剂量的影响。方法采用混合方法收敛设计。OTPs提取了377例患者的尿药检(UDT)结果、带回家的美沙酮方案和电子健康记录(EHR)中的治疗保留。混合效应负二项回归模型评估了COVID-19政策变化前后患者带回家剂量的差异,以及与停药和UDT阳性的关系。半结构化定性访谈(n = 32)探讨了患者对增加带回家剂量和减少门诊就诊的反应,为定量结果提供背景。结果在接受治疗超过180天的患者中,covid -19后带回家的剂量增加(中位数:每月8剂vs 13剂,p = 0.011)。治疗天数较少的患者,带回家的钱并没有增加。在没有COVID-19政策变化的情况下,带回家剂量每增加一个百分点,与阿片类药物UDT阳性百分比(B = - 0.12, CI [- 0.21, - 0.04], p = 0.005)和停药概率(aOR = 0.97, CI [0.95, 0.99], p = 0.003)呈负相关。定性分析揭示了三个主题,解释了增加的带回家剂量如何支持康复:1)承担更多责任的信任感的价值;2)减少旅行时间,增加就业和娱乐;3)减少与恢复不稳定和潜在诱因的个体的接触。结论在临床稳定的患者中,美沙酮剂量放松与美沙酮带回家剂量增加、保留率改善和UDT阿片阳性结果降低相关。定性调查结果表明,减少带回家的限制是可行和可取的,不会对安全或公共卫生造成危害。
{"title":"Treatment retention, return to use, and recovery support following COVID-19 relaxation of methadone take-home dosing in two rural opioid treatment programs: A mixed methods analysis","authors":"Kim A. Hoffman ,&nbsp;Canyon Foot ,&nbsp;Ximena A. Levander ,&nbsp;Ryan Cook ,&nbsp;Javier Ponce Terashima ,&nbsp;John W. McIlveen ,&nbsp;P. Todd Korthuis ,&nbsp;Dennis McCarty","doi":"10.1016/j.jsat.2022.108801","DOIUrl":"10.1016/j.jsat.2022.108801","url":null,"abstract":"<div><h3>Objectives</h3><p>In March 2020, the Substance Abuse and Mental Health Services Administration permitted Opioid Treatment Programs (OTPs) to relax restrictions on take-home methadone and promoted telehealth to minimize potential exposures to COVID-19. We assessed the effects of COVID-19-related changes on take-home methadone dosing in two OTPs serving five rural Oregon counties.</p></div><div><h3>Methods</h3><p>We used a mixed-methods convergent design. The OTPs extracted urine drug test (UDT) results, take-home methadone regimens, and treatment retention from the electronic health record (EHR) for patients (<em>n</em> = 377). A mixed-effects negative binomial regression model assessed patient-level differences in take-home doses before and after the COVID-19 policy changes and the associations with treatment discontinuation, and UDT positivity. Semi-structured qualitative interviews (<em>n</em> = 32) explored patient reactions to increased take-home dosing and reduced clinic visits to provide context for quantitative findings.</p></div><div><h3>Results</h3><p>The number of take-home doses increased in the post-COVID-19 period for patients engaged in treatment for more than 180 days (median: 8 vs 13 take-home doses per month, <em>p</em> = 0.011). Take-homes did not increase for patients with fewer days of treatment. Each percentage point increase in take-home dosing above what would be expected without COVID-19 policy changes was negatively associated with the percent of UDT positive for opioids (B = −0.12, CI [−0.21, −0.04], <em>p</em> = 0.005) and the probability of treatment discontinuation (aOR = 0.97, CI [0.95, 0.99], <em>p</em> = 0.003). Qualitative analysis revealed three themes explaining how increased take-home dosing supported recovery: 1) value of feeling trusted with increased responsibility; 2) reduced travel time permitted increased employment and recreation; and 3) reduced exposure to individuals less stable in recovery and potential triggers.</p></div><div><h3>Conclusions</h3><p>Take-home methadone dose relaxations were associated with increased methadone take-home doses, improved retention, and decreased UDT opioid positive results among clinically stable patients. Qualitative findings suggest that fewer take-home restrictions are feasible and desirable and do not pose safety or public health harms.</p></div>","PeriodicalId":17148,"journal":{"name":"Journal of Substance Abuse Treatment","volume":"141 ","pages":"Article 108801"},"PeriodicalIF":3.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9676383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Accessibility of substance use treatment: A qualitative study from the non-service users' perspective 物质使用治疗的可及性:非服务使用者视角的质性研究
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/j.jsat.2022.108779
Laura Caris , Thijs Beckers

Introduction

Despite having effective treatments for substance use disorders, the majority of people with a substance use disorder do not receive treatment, which leads to adverse personal, health, and social consequences. Experiences of non-service users have hardly been investigated in the literature. This study, which we conducted in the Netherlands, assessed the barriers to and facilitators of accessibility to substance use treatment for non-service users with substance use disorders.

Methods

The study team conducted a total of 10 individual, semi-structured interviews with participants recruited with the help of assertive outreach teams and public health services. A topic list guided the interviews. The interviews were transcribed, and the study team performed a thematic analysis.

Results

Six main themes related to the health care accessibility of substance use treatment emerged: treatment factors, stigmatization, personal factors, consequences of use, knowledge deficits, and social support. Personal factors, especially the non-service users' motivation, was a central determinant of whether they accessed substance use treatment. Social support and consequences of the substance use were perceived as facilitating access to treatment. Stigmatization and knowledge deficits had an important negative impact on the substance users' intrinsic motivation and thus on their ability to access health care. Specifically, stigmatization by health care professionals contributed to suboptimal treatment and recovery.

Conclusions

This study recommends interventions for health care professionals aimed at decreasing their stigma toward and knowledge deficits about substance use disorder. This study highlights the key role that primary health care providers can have in identifying substance use problems and facilitating the pathway to health care services for those with substance use disorders.

尽管对物质使用障碍有有效的治疗方法,但大多数物质使用障碍患者没有接受治疗,这导致了不利的个人、健康和社会后果。非服务使用者的经验在文献中几乎没有被调查。我们在荷兰进行的这项研究评估了药物使用障碍的非服务使用者获得药物使用治疗的障碍和促进因素。方法研究小组对在自信的外展小组和公共卫生服务机构的帮助下招募的参与者进行了10次单独的半结构化访谈。一份主题清单指导着采访。访谈被记录下来,研究小组进行了专题分析。结果出现了与药物使用治疗的卫生保健可及性相关的六个主题:治疗因素、污名化、个人因素、使用后果、知识缺陷和社会支持。个人因素,特别是非服务使用者的动机,是他们是否获得药物使用治疗的主要决定因素。社会支持和药物使用的后果被认为有助于获得治疗。污名化和知识缺陷对药物使用者的内在动机产生了重要的负面影响,从而影响了他们获得卫生保健的能力。具体来说,卫生保健专业人员的污名化导致了不理想的治疗和康复。结论本研究建议卫生保健专业人员采取干预措施,以减少他们对物质使用障碍的耻辱感和知识缺陷。这项研究强调了初级卫生保健提供者在确定物质使用问题和促进物质使用障碍患者获得卫生保健服务的途径方面可以发挥的关键作用。
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引用次数: 2
C2: editorial board C2:编委会
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/S0740-5472(22)00140-4
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引用次数: 0
TOC (update) TOC(更新)
IF 3.9 2区 医学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2022-10-01 DOI: 10.1016/S0740-5472(22)00141-6
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引用次数: 0
期刊
Journal of Substance Abuse Treatment
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