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Association between Mortality and Time Spent Out of Bed in Older-Adult Nursing Home Residents 老年人护理之家居民死亡率与下床时间的关系。
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-20 DOI: 10.1016/j.jamda.2024.105458
Shoji Kinoshita MD, PhD , Akio Shimizu RD, PhD , Naoki Yamada MD, PhD , Ryo Momosaki MD, PhD, MPH , Hidetaka Wakabayashi MD, PhD , Kotomi Sakai SLHT, PhD, MPH , Haruka Tohara DDS, PhD , Ryosuke Yanagida DDS , Tokiko Isowa RN, PHN, PhD , Kenta Ushida RPT, MMSc , Masahiro Abo MD, PhD

Objectives

For older adults, spending time out of bed is important for preventing functional decline, but its relationship to mortality is not clear. In this study, we aimed to investigate the association between mortality and time spent out of bed in Japanese older-adult nursing home residents.

Design

We conducted a cohort study using data from the Long-term Care Information System for Evidence database.

Setting and Participants

We used data collected between April 2022 and March 2024 from older-adult nursing home residents who required assistance with the activities of daily living.

Methods

We compared outcome data between residents who spent 6 or more hours per day out of bed (group L) and those who spent less than 6 hours per day out of bed (group S). The outcome was all-cause mortality. Data were analyzed using Kaplan-Meier curves and Cox regression models.

Results

Data from 185 older-adult nursing home residents (median age: 89 years; 141 women) were analyzed. Group L included 144 residents (77.8% of all participants). Of the 185 participants, 40 died during the observation period. Mortality in group L was significantly lower than in group S (16.7% vs 39.0%, P = .002). Kaplan-Meier curve analysis after the log-rank test revealed a significantly higher mortality in group S than group L. Univariate and multivariate Cox regression analyses with robust (Huber-White) standard errors identified the factor of time spent out of bed (≥6 h) as a significant and independent risk factor for mortality.

Conclusion and Implications

More time spent out of bed is associated with lower mortality in older-adult nursing home residents who require assistance with the activities of daily living.
目的:对于老年人来说,花时间离开床对预防功能衰退很重要,但其与死亡率的关系尚不清楚。在这项研究中,我们的目的是调查死亡率与日本老年人养老院居民的床上时间之间的关系。设计:我们使用来自长期护理信息系统证据数据库的数据进行了一项队列研究。环境和参与者:我们使用了2022年4月至2024年3月期间从需要日常生活活动帮助的老年养老院居民中收集的数据。方法:我们比较了每天下床时间超过6小时的住院患者(L组)和每天下床时间少于6小时的住院患者(S组)的结果数据。结果是全因死亡率。数据分析采用Kaplan-Meier曲线和Cox回归模型。结果:数据来自185名老年人养老院居民(中位年龄:89岁;141名女性)进行了分析。L组144名居民(占所有参与者的77.8%)。在185名参与者中,有40人在观察期间死亡。L组死亡率显著低于S组(16.7% vs 39.0%, P = 0.002)。log-rank检验后的Kaplan-Meier曲线分析显示,S组的死亡率显著高于l组。单因素和多因素Cox回归分析显示,具有稳健(Huber-White)标准误差的因素确定,下床时间(≥6小时)是死亡率的重要独立危险因素。结论和意义:对于需要帮助进行日常生活活动的老年人来说,更多的卧床时间与较低的死亡率相关。
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引用次数: 0
Evaluation of COVID-19 Diagnosis Codes for Identification of SARS-CoV-2 Infections in a Nursing Home Cohort, 2022–2023 2022-2023年敬老院队列SARS-CoV-2感染诊断代码评价
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-18 DOI: 10.1016/j.jamda.2024.105440
Arshiya Patel MPH , Amanda B. Payne PhD, MPH , Dustin W. Currie PhD, MPH , Thomas Franceschini MBA , Amber Gensheimer MSN, RN , Joseph D. Lutgring MD , Sujan C. Reddy MD, MSc , Kelly M. Hatfield DrPH, MSPH

Objectives

This study aimed to evaluate the utility of electronic health record (EHR) diagnosis codes for monitoring SARS-CoV-2 infections among nursing home residents.

Design

A retrospective cohort study design was used to analyze data collected from nursing homes operating under the tradename Signature Healthcare between January 2022 and June 2023.

Setting and Participants

Data from 31,136 nursing home residents across 76 facilities in Kentucky, Tennessee, Indiana, Ohio, North Carolina, Georgia, Alabama, and Virginia were included.

Methods

Resident demographics, diagnosis codes associated with clinical diagnoses (including COVID-19), and SARS-CoV-2 testing information were collected from the EHR and supplemental testing data sources. We described the rates of infection and the clinical characteristics of residents with incident-positive SARS-CoV-2 tests and new-onset COVID-19 diagnoses. Positive predictive values (PPVs) of COVID-19 diagnosis codes were calculated for residents stratified by whether a resident was continuously present in a facility for ±3 days from the diagnosis onset date listed in EHRs, using positive SARS-CoV-2 tests to confirm infection.

Results

A total of 4876 incident-positive SARS-CoV-2 tests and 6346 new-onset COVID-19 diagnoses were recorded during the study period. Weekly rates of new-onset diagnoses were significantly higher than positive test rates, although trends followed similar trajectories. Among residents continuously present in the nursing home ±3 days from the diagnosis onset date, the PPV of COVID-19 diagnosis codes was high (3395 of 3685 = 92%; 95% CI, 91%–93%). The PPV among this group significantly varied by study quarter (P < .001). The PPV was substantially lower for 2661 diagnoses among residents not continuously present in the nursing home (24%; 95% CI, 22%–26%).

Conclusions and Implications

This study demonstrates the utility of diagnosis codes for assessment of COVID-19 epidemiology and trends when testing data are unavailable for residents during their stay in a nursing home. Future research should explore strategies to evaluate the utility of diagnosis codes at admission and discharge to nursing homes to enhance surveillance efforts.
目的:本研究旨在评估电子健康档案(EHR)诊断代码在养老院居民SARS-CoV-2感染监测中的应用价值。设计:采用回顾性队列研究设计,分析从2022年1月至2023年6月以Signature Healthcare商标经营的养老院收集的数据。环境和参与者:来自肯塔基州、田纳西州、印第安纳州、俄亥俄州、北卡罗来纳州、佐治亚州、阿拉巴马州和弗吉尼亚州76家养老院的31,136名养老院居民的数据包括在内。方法:从电子病历和补充检测数据源中收集居民人口统计信息、与临床诊断(包括COVID-19)相关的诊断代码和SARS-CoV-2检测信息。我们描述了SARS-CoV-2检测阳性和新发COVID-19诊断的居民的感染率和临床特征。根据居民是否从电子病历中列出的诊断发病日期起连续在医疗机构中居住±3天,使用阳性SARS-CoV-2检测确认感染,对分层居民计算COVID-19诊断代码的阳性预测值(ppv)。结果:在研究期间,共记录4876例SARS-CoV-2事件阳性检测和6346例新发COVID-19诊断。每周新发诊断率明显高于阳性检测率,尽管趋势遵循相似的轨迹。在自诊断发病日起±3 d内持续在养老院居住的居民中,COVID-19诊断代码PPV较高(3685 / 3395 = 92%;95% ci, 91%-93%)。两组患者的PPV在不同研究季度间差异有统计学意义(P < 0.001)。在没有持续住在养老院的居民中,2661例诊断的PPV明显较低(24%;95% ci, 22%-26%)。结论和意义:本研究表明,当居民在养老院居住期间无法获得检测数据时,诊断代码在评估COVID-19流行病学和趋势方面的效用。未来的研究应探索评估疗养院入院和出院时诊断代码的效用的策略,以加强监测工作。
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引用次数: 0
Long-Stay Nursing Home Residents with Dementia: Telemedicine Mental Health Use during the COVID-19 Pandemic 患有痴呆症的长期护理之家居民:COVID-19大流行期间远程医疗心理健康的使用
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-16 DOI: 10.1016/j.jamda.2024.105438
Qiuyuan Qin MS , Helena Temkin-Greener PhD , Adam Simning PhD , Reza Yousefi-Nooraie PhD , Shubing Cai PhD

Objective

To examine racial and ethnic differences in telemedicine mental health (tele-MH) use among nursing home (NH) long-stay residents with Alzheimer’s disease and related dementias (ADRD) during the pandemic.

Design

Observational study.

Setting and Participants

The 2020–2021 Minimum Data Set 3.0, Medicare datasets, and Nursing Home Compare data were linked. A total of 259,467 NH long-stay residents with ADRD and 14,159 NHs were included.

Methods

The outcome variable was the percentage of NH ADRD long-stayers who used tele-MH in 2021. The main independent variables were NH racial and ethnic compositions (ie, percentages of Black and Hispanic residents) and individual race and ethnicity. We conducted a set of logistic regression models with NH random effect. We first included only individual characteristics and then added NH characteristics.

Results

Approximately 7% and 35% of the study cohort had tele-MH use and MH use in 2021, respectively. In our study cohort, 13.7% were Black, 6.6% were Hispanic, and 79.7% were white residents. The mean age was 83.4. After adjusting for NH characteristics, we found residents in NHs with a high proportion of Hispanic residents were more likely to use tele-MH both compared with those in NHs with a low proportion [odds ratio (OR), 1.867; 95% CI, 1.566–2.226], whereas residents in NHs with a high proportion of Black residents were less likely to use tele-MH both compared with those in NHs with a low proportion (OR, 0.843; 95% CI, 0.928–0.997).

Conclusions and Implications

Telemedicine may offer an opportunity for NHs with a higher proportion of Hispanic residents to better address their needs for MH services. However, NHs with a higher proportion of Black residents may face challenges in telemedicine adoption. Future studies are needed to better understand factors that could impact tele-MH use in NHs and reasons that lead to racial and ethnic differences.
目的:探讨大流行期间阿尔茨海默病及相关痴呆(ADRD)长期居住在养老院(NH)的居民远程医疗心理健康(tele-MH)使用的种族差异。设计:观察性研究。环境和参与者:2020-2021年最低数据集3.0、医疗保险数据集和养老院比较数据被链接。共包括259,467名患有ADRD的NH长期居民和14,159名NHs居民。方法:结局变量为2021年使用远程mh的NH ADRD长期住院患者的百分比。主要的自变量是NH种族和民族构成(即黑人和西班牙裔居民的百分比)和个人种族和民族。我们建立了一套具有NH随机效应的logistic回归模型。我们首先只考虑了个体特征,然后加入了NH特征。结果:大约7%和35%的研究队列在2021年分别使用远程MH和MH。在我们的研究队列中,13.7%为黑人,6.6%为西班牙裔,79.7%为白人。平均年龄为83.4岁。在调整了NH特征后,我们发现西班牙裔居民比例高的NHs居民比西班牙裔居民比例低的NHs居民更有可能使用远程mh(优势比[OR], 1.867;95% CI, 1.566-2.226),而黑人居民比例高的NHs居民与黑人居民比例低的NHs居民相比,使用远程mh的可能性更小(OR, 0.843;95% ci, 0.928-0.997)。结论和意义:远程医疗可能为西班牙裔居民比例较高的NHs提供机会,以更好地解决他们对MH服务的需求。然而,黑人居民比例较高的NHs在采用远程医疗方面可能面临挑战。未来的研究需要更好地了解可能影响NHs远程mh使用的因素以及导致种族和民族差异的原因。
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引用次数: 0
Environmental and Clinical Factors Concerning Gastrointestinal Bleeding: An Umbrella Review of Meta-Analyses. 胃肠道出血的环境和临床因素:荟萃分析综述。
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-13 DOI: 10.1016/j.jamda.2024.105412
Keqian Yi, Yu Ma, Pengcheng Zhang, Haiyu He, Yueying Lin, Dali Sun

Objectives: Gastrointestinal bleeding, an emergency and critical disease, is affected by multiple factors. This study aims to systematically summarize and appraise various factors associated with gastrointestinal bleeding.

Design: Umbrella review.

Setting and participants: Meta-analyses that evaluated environmental and clinical factors concerning gastrointestinal bleeding.

Methods: We conducted a systematic search to identify eligible meta-analyses. For each included study, the risk estimates, heterogeneity estimates, small-study effects, excess significance tests, and publication biases were recalculated and appraised. Furthermore, we considered the methodologic quality and classified the evidence.

Results: In this study, 51 beneficial and 44 harmful associations were found. This study found that preemptive transjugular intrahepatic portosystemic shunt was the most reliable treatment to reduce gastroesophageal variceal bleeding and mortality risk, followed by antibiotics. For gastroduodenal ulcer bleeding, Yunnan Baiyao and proton pump inhibitors (PPIs) were relatively dependable treatment drugs, and the comparatively reliable prophylactic drugs comprised PPIs and H2-receptor antagonists. Patients with hemodynamic instability and larger ulcers had a higher risk of rebleeding. Both weekend admissions and the combination of selective serotonin reuptake inhibitors and nonsteroidal anti-inflammatory drugs were high-risk factors for upper gastrointestinal bleeding and mortality. We also found that tranexamic acid was a credible drug for overall gastrointestinal bleeding. Meanwhile, aspirin, warfarin, diabetes, and renal failure were all high-risk factors.

Conclusions and implications: Altogether, many factors can substantially influence gastrointestinal bleeding. Therefore, in daily life and clinical practice, we should not only remain cautious in prescribing and taking some drugs but also pay attention to the management of lifestyle and underlying diseases. If necessary, protective drugs should be properly supplemented.

目的:消化道出血是一种受多种因素影响的急危疾病。本研究旨在系统总结和评价与消化道出血相关的各种因素。设计:伞式审查。环境和参与者:荟萃分析评估与胃肠道出血有关的环境和临床因素。方法:我们进行了系统搜索,以确定符合条件的meta分析。对于每一项纳入的研究,重新计算和评价风险估计、异质性估计、小研究效应、过度显著性检验和发表偏倚。此外,我们还考虑了方法质量并对证据进行了分类。结果:本研究发现51种有益关联,44种有害关联。本研究发现,先发制人的经颈静脉肝内门静脉系统分流术是减少胃食管静脉曲张出血和死亡风险的最可靠的治疗方法,其次是抗生素。对于胃十二指肠溃疡出血,云南白药和质子泵抑制剂(PPIs)是相对可靠的治疗药物,而相对可靠的预防药物是PPIs和h2受体拮抗剂。血流动力学不稳定和较大溃疡的患者再出血的风险较高。周末入院以及选择性血清素再摄取抑制剂和非甾体抗炎药的联合使用是上消化道出血和死亡率的高危因素。我们还发现氨甲环酸是治疗消化道出血的可靠药物。同时,阿司匹林、华法林、糖尿病和肾衰竭都是高危因素。结论和意义:总的来说,许多因素可以实质上影响胃肠道出血。因此,在日常生活和临床实践中,我们不仅要谨慎地开处方和服用一些药物,还要注意生活方式和基础疾病的管理。必要时应适当补充保护性药物。
{"title":"Environmental and Clinical Factors Concerning Gastrointestinal Bleeding: An Umbrella Review of Meta-Analyses.","authors":"Keqian Yi, Yu Ma, Pengcheng Zhang, Haiyu He, Yueying Lin, Dali Sun","doi":"10.1016/j.jamda.2024.105412","DOIUrl":"https://doi.org/10.1016/j.jamda.2024.105412","url":null,"abstract":"<p><strong>Objectives: </strong>Gastrointestinal bleeding, an emergency and critical disease, is affected by multiple factors. This study aims to systematically summarize and appraise various factors associated with gastrointestinal bleeding.</p><p><strong>Design: </strong>Umbrella review.</p><p><strong>Setting and participants: </strong>Meta-analyses that evaluated environmental and clinical factors concerning gastrointestinal bleeding.</p><p><strong>Methods: </strong>We conducted a systematic search to identify eligible meta-analyses. For each included study, the risk estimates, heterogeneity estimates, small-study effects, excess significance tests, and publication biases were recalculated and appraised. Furthermore, we considered the methodologic quality and classified the evidence.</p><p><strong>Results: </strong>In this study, 51 beneficial and 44 harmful associations were found. This study found that preemptive transjugular intrahepatic portosystemic shunt was the most reliable treatment to reduce gastroesophageal variceal bleeding and mortality risk, followed by antibiotics. For gastroduodenal ulcer bleeding, Yunnan Baiyao and proton pump inhibitors (PPIs) were relatively dependable treatment drugs, and the comparatively reliable prophylactic drugs comprised PPIs and H<sub>2</sub>-receptor antagonists. Patients with hemodynamic instability and larger ulcers had a higher risk of rebleeding. Both weekend admissions and the combination of selective serotonin reuptake inhibitors and nonsteroidal anti-inflammatory drugs were high-risk factors for upper gastrointestinal bleeding and mortality. We also found that tranexamic acid was a credible drug for overall gastrointestinal bleeding. Meanwhile, aspirin, warfarin, diabetes, and renal failure were all high-risk factors.</p><p><strong>Conclusions and implications: </strong>Altogether, many factors can substantially influence gastrointestinal bleeding. Therefore, in daily life and clinical practice, we should not only remain cautious in prescribing and taking some drugs but also pay attention to the management of lifestyle and underlying diseases. If necessary, protective drugs should be properly supplemented.</p>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":" ","pages":"105412"},"PeriodicalIF":4.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Nursing Home Changes in Antipsychotic Use on Outcomes among Residents with Dementia 养老院抗精神病药物使用变化对痴呆患者预后的影响
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-10 DOI: 10.1016/j.jamda.2024.105439
Andrew R. Zullo PharmD, PhD , Melissa R. Riester PharmD , Hiren Varma MS , Lori A. Daiello PharmD, ScM , Lauren B. Gerlach DO, MS , Antoinette B. Coe PharmD, PhD , Kali S. Thomas PhD , Richa Joshi MS, MBA , Tingting Zhang MD, PhD , Theresa I. Shireman PhD , Julie P.W. Bynum MD, MPH

Objectives

Little information exists on whether nationwide efforts to reduce antipsychotic use among nursing home (NH) residents with Alzheimer's disease and related dementias improved mortality and hospitalization outcomes for residents. Our objective was to examine the effect of NH decreases in antipsychotic use on outcomes for residents with Alzheimer's disease and related dementias.

Design

Observational nationwide study that emulated a series of cluster randomized trials.

Setting and Participants

Long-stay NH residents with Alzheimer's disease and related dementias in US NHs.

Methods

The study used data from Medicare claims to emulate cluster randomized trials in which NHs were assigned to either decrease or maintain/increase antipsychotic use. Outcome ascertainment for the first trial began on April 1, 2012 (ie, following the announcement of the National Partnership to Improve Dementia Care in NHs). The last day of follow-up was December 31, 2017. Outcomes measured included 12-month all-cause mortality, all-cause hospitalization, and hospitalization for stroke, myocardial infarction, fracture, and psychiatric conditions. Use of other psychotropic medications was also evaluated. Inverse-probability-of-treatment-weighted pooled Poisson regression models estimated covariate-adjusted risk ratios (RRs).

Results

The adjusted risks of death (RR, 1.01; 95% CLs, 1.00, 1.01), all-cause hospitalization (RR, 1.00; 95% CLs, 1.00, 1.01), and hospitalization for specific causes were similar between resident-trials in NHs that decreased vs maintained/increased antipsychotic use. Use of antidepressants, anxiolytic/sedative-hypnotics, anticonvulsant/mood stabilizers, and antidementia medications was slightly higher among resident-trials in NHs that decreased antipsychotic use.

Conclusions and Implications

Decreases in NH antipsychotic use do not appear to improve resident outcomes. Intensive initiatives focused predominantly on achieving a decrease in antipsychotic use may not be effective at improving mortality and hospitalization outcomes for residents with Alzheimer's disease and related dementias. These findings suggest the need for better strategies that incorporate safe and effective nonpharmacological or pharmacological alternatives for managing neuropsychiatric symptoms of dementia.
目的:关于全国范围内减少阿尔茨海默病和相关痴呆养老院(NH)居民抗精神病药物使用是否能改善居民死亡率和住院治疗结果的信息很少。我们的目的是检查NH减少抗精神病药物使用对阿尔茨海默病和相关痴呆患者预后的影响。设计:全国范围的观察性研究,模拟了一系列的集群随机试验。背景和参与者:长期居住在美国国家医疗服务体系中患有阿尔茨海默病和相关痴呆的NH居民。方法:该研究使用来自医疗保险索赔的数据来模拟集群随机试验,其中NHs被分配减少或维持/增加抗精神病药物的使用。第一次试验的结果确定始于2012年4月1日(即,在国民保健服务中改善痴呆症护理国家伙伴关系宣布之后)。随访的最后一天为2017年12月31日。测量的结果包括12个月的全因死亡率、全因住院以及因中风、心肌梗死、骨折和精神疾病住院。其他精神药物的使用情况也进行了评估。治疗逆概率加权泊松回归模型估计协变量调整风险比(rr)。结果:调整后的死亡风险(RR, 1.01;95% CLs, 1.00, 1.01),全因住院(RR, 1.00;95% CLs(1.00, 1.01)和因特定原因住院治疗在减少与维持/增加抗精神病药物使用的NHs住院试验中相似。抗抑郁药、抗焦虑药/镇静催眠药、抗惊厥药/情绪稳定剂和抗痴呆药的使用在减少抗精神病药使用的NHs住院试验中略高。结论和意义:NH抗精神病药物使用的减少似乎并没有改善住院患者的预后。主要侧重于减少抗精神病药物使用的强化举措可能无法有效改善阿尔茨海默病及相关痴呆患者的死亡率和住院治疗结果。这些发现表明需要更好的策略,包括安全有效的非药物或药物替代治疗痴呆症的神经精神症状。
{"title":"Effects of Nursing Home Changes in Antipsychotic Use on Outcomes among Residents with Dementia","authors":"Andrew R. Zullo PharmD, PhD ,&nbsp;Melissa R. Riester PharmD ,&nbsp;Hiren Varma MS ,&nbsp;Lori A. Daiello PharmD, ScM ,&nbsp;Lauren B. Gerlach DO, MS ,&nbsp;Antoinette B. Coe PharmD, PhD ,&nbsp;Kali S. Thomas PhD ,&nbsp;Richa Joshi MS, MBA ,&nbsp;Tingting Zhang MD, PhD ,&nbsp;Theresa I. Shireman PhD ,&nbsp;Julie P.W. Bynum MD, MPH","doi":"10.1016/j.jamda.2024.105439","DOIUrl":"10.1016/j.jamda.2024.105439","url":null,"abstract":"<div><h3>Objectives</h3><div>Little information exists on whether nationwide efforts to reduce antipsychotic use among nursing home (NH) residents with Alzheimer's disease and related dementias improved mortality and hospitalization outcomes for residents. Our objective was to examine the effect of NH decreases in antipsychotic use on outcomes for residents with Alzheimer's disease and related dementias.</div></div><div><h3>Design</h3><div>Observational nationwide study that emulated a series of cluster randomized trials.</div></div><div><h3>Setting and Participants</h3><div>Long-stay NH residents with Alzheimer's disease and related dementias in US NHs.</div></div><div><h3>Methods</h3><div>The study used data from Medicare claims to emulate cluster randomized trials in which NHs were assigned to either decrease or maintain/increase antipsychotic use. Outcome ascertainment for the first trial began on April 1, 2012 (ie, following the announcement of the National Partnership to Improve Dementia Care in NHs). The last day of follow-up was December 31, 2017. Outcomes measured included 12-month all-cause mortality, all-cause hospitalization, and hospitalization for stroke, myocardial infarction, fracture, and psychiatric conditions. Use of other psychotropic medications was also evaluated. Inverse-probability-of-treatment-weighted pooled Poisson regression models estimated covariate-adjusted risk ratios (RRs).</div></div><div><h3>Results</h3><div>The adjusted risks of death (RR, 1.01; 95% CLs, 1.00, 1.01), all-cause hospitalization (RR, 1.00; 95% CLs, 1.00, 1.01), and hospitalization for specific causes were similar between resident-trials in NHs that decreased vs maintained/increased antipsychotic use. Use of antidepressants, anxiolytic/sedative-hypnotics, anticonvulsant/mood stabilizers, and antidementia medications was slightly higher among resident-trials in NHs that decreased antipsychotic use.</div></div><div><h3>Conclusions and Implications</h3><div>Decreases in NH antipsychotic use do not appear to improve resident outcomes. Intensive initiatives focused predominantly on achieving a decrease in antipsychotic use may not be effective at improving mortality and hospitalization outcomes for residents with Alzheimer's disease and related dementias. These findings suggest the need for better strategies that incorporate safe and effective nonpharmacological or pharmacological alternatives for managing neuropsychiatric symptoms of dementia.</div></div>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":"26 3","pages":"Article 105439"},"PeriodicalIF":4.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Sources and Experiences of Joy in Caregiving: Insights From Formal Caregivers in Long-Term Care 探索护理中快乐的来源和体验:来自长期护理中正式照顾者的见解。
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-09 DOI: 10.1016/j.jamda.2024.105437
Lillian Hung RN, PhD , Nathan A. Boucher DrPH, PA, MPA, MS , Lily Haopu Ren PhD , Karen Lok Yi Wong RSW, MA, MSW , Joey Oi Yee Wong PhD , Yong Zhao MD , Tiffany Wu MSc

Objectives

To explore and understand the sources and experiences of joy in caregiving among formal caregivers in Canadian long-term care (LTC).

Design

A qualitative study with interpretative descriptive design.

Setting and Participants

The participants consisted of 20 formal caregivers from a large public LTC home in British Columbia, Canada, focusing on those with at least 6 months of direct caregiving experience.

Methods

Convenience sampling was conducted to recruit participants. Data were collected through 3 focus groups, with discussions moderated by the primary investigator, and were audio recorded and transcribed. Reflexive thematic analysis was used to identify themes, combining inductive and deductive strategies. To enhance rigor and trustworthiness, the research team engaged in reflective practices, leveraging diverse expertise, and ensuring a rich description of the study context. The study received ethical approval, and participant confidentiality was maintained through pseudonyms.

Results

Three interconnected themes of joy in caregiving were identified: (1) Joy in caregiving is a relational and dynamic process that evolves over time and coexists with other emotions, such as sadness and grief. (2) Joy is driven by an attitude shaped by the environment, stemming from an internal attitude, and contributing to a deeper sense of fulfillment despite challenges. (3) Joy in caregiving builds personal team resilience that reduces burnout, fostering compassion and creating a supportive atmosphere through gratitude and shared experiences, benefiting caregivers and residents.

Conclusions and Implications

This study highlights the relational and evolving nature of joy in caregiving, the influence of internal attitudes and supportive environments, and the impact of joy on resilience and burnout. The findings contribute to characterizing how joy functions within caregiving contexts—specifically for LTC workers—and its broader implications for caregiver well-being and team dynamics.
目的:探讨和了解加拿大长期护理(LTC)中正式护理人员照顾快乐的来源和体验。设计:具有解释性描述设计的定性研究。环境和参与者:参与者包括来自加拿大不列颠哥伦比亚省一家大型公共LTC家庭的20名正式护理人员,重点是那些至少有6个月直接护理经验的人。方法:采用方便抽样的方法进行调查。数据通过3个焦点小组收集,讨论由主要研究者主持,并录音和转录。运用反身性主位分析识别主位,归纳与演绎相结合。为了提高严谨性和可信度,研究团队进行了反思实践,利用了不同的专业知识,并确保对研究背景进行了丰富的描述。该研究获得了伦理批准,参与者通过笔名保密。结果:发现了照顾快乐的三个相互关联的主题:(1)照顾快乐是一个随时间演变的关系动态过程,并与其他情绪(如悲伤和悲伤)共存。(2)快乐是由环境塑造的一种态度所驱动的,源于一种内在的态度,并有助于在挑战中获得更深层次的满足感。(3)照护的乐趣可以建立个人团队的弹性,减少倦怠,培养同情心,并通过感恩和分享经验创造支持氛围,使照护者和住院患者受益。结论与启示:本研究强调了护理中快乐的关系和演变性质,内部态度和支持环境的影响,以及快乐对恢复力和倦怠的影响。这些发现有助于描述快乐在照顾环境中的作用——特别是对LTC员工——以及它对照顾者幸福感和团队动力的更广泛影响。
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引用次数: 0
Frail Older Adults with High Anticholinergic Burden are at Risk of Orthostatic Hypotension 抗胆碱能负荷高的体弱老年人有发生直立性低血压的风险。
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-04 DOI: 10.1016/j.jamda.2024.105436
Mehmet Ilkin Naharci PhD

Objectives

Frailty has been shown to be linked with orthostatic hypotension (OH) in older adults, but the role of anticholinergic drugs in this relationship never has been explored. The purpose of this was to examine the relationship between anticholinergic burden (ACB) and OH in frail older adults living in the community and to examine whether this association differs according to polypharmacy.

Design

A cross-sectional study.

Setting and Participants

Frail community-dwelling individuals aged ≥65 years admitted to the geriatric outpatient clinic (n = 399).

Methods

Frailty status was defined by having ≥3 clinical features of the Fried Frailty Index. OH was a drop of ≥20 mm Hg in systolic blood pressure or a drop of ≥10 mm Hg in diastolic blood pressure 1 or 3 min after rising from a sitting position. ACB for each participant was categorized as none (ACB = 0), low (ACB = 1), or high (ACB ≥2). Multivariate logistic regression models were implemented to examine the association of ACB with OH.

Results

The mean age of the sample was 79.8 years and 59.9% were women; 59 (13.3%) participants had OH. Exposure to anticholinergics was present in 41.4% of the participants, polypharmacy in 48.1%, and potentially inappropriate drug use in 44.1%. Multivariate analysis yielded a statistically significant risk of high ACB-related OH in the fully adjusted model [OR: 4.14 (1.33–12.86), P = .014]. None of the interaction terms of ACB with polypharmacy were significant in any model.

Conclusions and Implications

In frail older people, because exposure to a high anticholinergic load may be associated with OH, special attention should be paid to anticholinergics in medical treatment to prevent a reduction in blood pressure upon standing.
目的:虚弱已被证明与老年人直立性低血压(OH)有关,但抗胆碱能药物在这种关系中的作用从未被探索过。本研究的目的是研究生活在社区的体弱老年人抗胆碱能负荷(ACB)与OH之间的关系,并研究这种关联是否因多种用药而有所不同。设计:横断面研究。环境和参与者:老年门诊收治的≥65岁社区居住体弱个体(n = 399)。方法:以具有≥3个Fried衰弱指数临床特征来定义虚弱状态。OH是指从坐姿起身后1分钟或3分钟收缩压下降≥20 mm Hg或舒张压下降≥10 mm Hg。每个参与者的ACB分为无(ACB = 0)、低(ACB = 1)和高(ACB≥2)。采用多变量logistic回归模型检验ACB与OH的关系。结果:本组患者平均年龄79.8岁,女性占59.9%;59例(13.3%)患者有OH。41.4%的参与者暴露于抗胆碱能药物,48.1%的参与者服用多种药物,44.1%的参与者可能不适当使用药物。多因素分析显示,在完全调整模型中,acb相关的高OH风险具有统计学意义[OR: 4.14 (1.33-12.86), P = 0.014]。在任何模型中,ACB与多药的相互作用项均不显著。结论和意义:在体弱多病的老年人中,由于暴露于高抗胆碱能负荷可能与OH有关,在医学治疗中应特别注意抗胆碱能药物,以防止站立时血压下降。
{"title":"Frail Older Adults with High Anticholinergic Burden are at Risk of Orthostatic Hypotension","authors":"Mehmet Ilkin Naharci PhD","doi":"10.1016/j.jamda.2024.105436","DOIUrl":"10.1016/j.jamda.2024.105436","url":null,"abstract":"<div><h3>Objectives</h3><div>Frailty has been shown to be linked with orthostatic hypotension (OH) in older adults, but the role of anticholinergic drugs in this relationship never has been explored. The purpose of this was to examine the relationship between anticholinergic burden (ACB) and OH in frail older adults living in the community and to examine whether this association differs according to polypharmacy.</div></div><div><h3>Design</h3><div>A cross-sectional study.</div></div><div><h3>Setting and Participants</h3><div>Frail community-dwelling individuals aged ≥65 years admitted to the geriatric outpatient clinic (n = 399).</div></div><div><h3>Methods</h3><div>Frailty status was defined by having ≥3 clinical features of the Fried Frailty Index. OH was a drop of ≥20 mm Hg in systolic blood pressure or a drop of ≥10 mm Hg in diastolic blood pressure 1 or 3 min after rising from a sitting position. ACB for each participant was categorized as none (ACB = 0), low (ACB = 1), or high (ACB ≥2). Multivariate logistic regression models were implemented to examine the association of ACB with OH.</div></div><div><h3>Results</h3><div>The mean age of the sample was 79.8 years and 59.9% were women; 59 (13.3%) participants had OH. Exposure to anticholinergics was present in 41.4% of the participants, polypharmacy in 48.1%, and potentially inappropriate drug use in 44.1%. Multivariate analysis yielded a statistically significant risk of high ACB-related OH in the fully adjusted model [OR: 4.14 (1.33–12.86), <em>P</em> = .014]. None of the interaction terms of ACB with polypharmacy were significant in any model.</div></div><div><h3>Conclusions and Implications</h3><div>In frail older people, because exposure to a high anticholinergic load may be associated with OH, special attention should be paid to anticholinergics in medical treatment to prevent a reduction in blood pressure upon standing.</div></div>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":"26 3","pages":"Article 105436"},"PeriodicalIF":4.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
General Information
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/S1525-8610(24)00871-5
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引用次数: 0
Measurement Practice of Slow Gait Speed for Motoric Cognitive Risk Syndrome: A Systematic Review 运动性认知风险综合征的缓慢步速测量实践:系统回顾
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.jamda.2024.105361
Lina Wang PhD , Liming Su MD , Lulu Shi MD , Dan Zhao PhD , Chen Zhang BSMed , Bei Wu PhD

Objectives

Individuals with motoric cognitive risk (MCR) syndrome have a high dementia risk. However, a knowledge gap exists in the measurement procedure for slow gait speed, which is a crucial component of MCR diagnosis. The study aimed to systematically review slow gait speed measurement practices in MCR diagnosis to identify critical constructs in gait speed measurement procedure.

Design

Systematic review.

Setting and Participants

Included studies were conducted in clinical and community settings, involving participants with MCR receiving gait speed measurement.

Methods

A systematic search across PubMed, Medline, Embase, CINHAL (EBSCO), Web of Science, Cochrane Library, and ProQuest Dissertation from inception until January 2024 for articles with detailed MCR diagnosis. Study quality was evaluated with the Joanna Briggs Institute (JBI) Critical Appraisal Checklists and slow gait speed measurement methods were summarized through narrative synthesis.

Results

From 27,600 unique entries, 50 relevant studies with 55 cohorts were identified and included in the review. Slow gait speed measurement methods in existing MCR studies showed heterogeneity in measurement tools, start/end protocols and buffer distance, walking test distance, number of tests, calculation methods, and cutoff values. Commonly, manual stopwatches and 4-meter walking test distance with a 2-meter buffer at each end at a usual pace were used, averaging 2 tests for gait speed analysis, with the need for cohort-specific slow gait cutoff values.

Conclusions and Implications

The measurement practices of slow gait speed in MCR diagnosis were heterogeneous. A relatively comprehensive gait speed measurement procedure with 7 constructs was initially delineated in this study based on synthesis analysis, with the potential to improve diagnostic accuracy and consistency of MCR, although further validation is still needed.
研究目的运动性认知风险(MCR)综合征患者有很高的痴呆风险。然而,作为 MCR 诊断的重要组成部分,慢步态速度的测量程序存在知识空白。该研究旨在系统回顾MCR诊断中缓慢步态速度的测量方法,以确定步态速度测量程序中的关键结构:设计:系统回顾:纳入的研究均在临床和社区环境中进行,涉及接受步速测量的 MCR 患者:方法:从开始到 2024 年 1 月,在 PubMed、Medline、Embase、CINHAL (EBSCO)、Web of Science、Cochrane Library 和 ProQuest Dissertation 等网站上进行系统检索,以获取详细的 MCR 诊断文章。研究质量采用乔安娜-布里格斯研究所(JBI)的批判性评估检查表进行评估,并通过叙事综合法对缓慢步速测量方法进行总结:从 27,600 个独立条目中,确定了 50 项相关研究和 55 个队列,并将其纳入综述。现有 MCR 研究中的慢步速度测量方法在测量工具、开始/结束方案和缓冲距离、步行测试距离、测试次数、计算方法和临界值等方面存在异质性。常见的方法是使用手动秒表和4米步行测试距离,两端各2米缓冲距离,以正常速度步行,平均2次测试进行步态速度分析,同时需要针对队列的慢步态临界值:在 MCR 诊断中,对缓慢步速的测量方法各不相同。本研究在综合分析的基础上初步确定了一个包含 7 个结构的相对全面的步速测量程序,该程序有可能提高 MCR 诊断的准确性和一致性,但仍需进一步验证。
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引用次数: 0
Directions & Connections
IF 4.2 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/S1525-8610(24)00872-7
{"title":"Directions & Connections","authors":"","doi":"10.1016/S1525-8610(24)00872-7","DOIUrl":"10.1016/S1525-8610(24)00872-7","url":null,"abstract":"","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":"26 1","pages":"Article 105450"},"PeriodicalIF":4.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143098577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of the American Medical Directors Association
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