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Systematic Review and Meta-Analysis: Effectiveness of Intensive Community Care Services and Psychosocial Interventions for Adolescents With Severe Mental Health Problems 系统回顾和荟萃分析:强化社区护理服务和社会心理干预对严重精神健康问题青少年的有效性
IF 13.3 1区 医学 Q1 PEDIATRICS Pub Date : 2026-01-22 DOI: 10.1016/j.jaac.2026.01.006
Shabeer Syed, Ana Pascual Sanchez, Pleasant Adesiyan, Katherine Rabot, Leigh J. Sanson, Rebecca Eaton, Dennis Ougrin
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引用次数: 0
Illegal: A Disappeared Novel 非法:一本消失的小说
IF 13.3 1区 医学 Q1 PEDIATRICS Pub Date : 2026-01-15 DOI: 10.1016/j.jaac.2025.12.013
Kayla Chory, Suzie Hong, Shawn Singh Sidhu
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引用次数: 0
Brain Stimulation Therapies for Clinicians, Second Edition 临床医生的脑刺激疗法,第二版
IF 13.3 1区 医学 Q1 PEDIATRICS Pub Date : 2026-01-14 DOI: 10.1016/j.jaac.2025.12.015
Ebrahim Payberah
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引用次数: 0
Precision Optimization of Behavioral Activation for Major and Subthreshold Depression: A Meta-Analysis of Exploring Dose-Response Relationships and Moderating Factors 重度和阈下抑郁症行为激活的精确优化:剂量-反应关系及调节因素的meta分析
IF 13.3 1区 医学 Q1 PEDIATRICS Pub Date : 2026-01-05 DOI: 10.1016/j.jaac.2025.12.019
Xiaolong Huang, Wei Luo, Jiacheng Luo, Yan Zhang, Yuqi Chen, Yuqing Luo, Bin Sun, Yanling Zhou
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引用次数: 0
Transcriptional Signatures of Mitochondrial Metabolism Predict Esketamine-Induced rACC Structural Changes in Adolescent Major Depression. 线粒体代谢的转录特征预测艾氯胺酮诱导的青少年重度抑郁症的rACC结构变化。
IF 9.5 1区 医学 Q1 PEDIATRICS Pub Date : 2025-12-31 DOI: 10.1016/j.jaac.2025.12.011
Weicheng Li, Xiaofeng Lan, Chengyu Wang, Xiaoyu Chen, Zhanjie Luo, Fan Zhang, Guanxi Liu, Zitao Wu, Junhao Shen, Ziying Chen, Haobing Zhu, Xuan Liu, Yiyun Xue, Hanna Lu, Jichun Zhang, Xiangdong Sun, Kenji Hashimoto, Yuping Ning, Yanling Zhou
<p><strong>Objective: </strong>To investigate neurobiological mechanisms through which esketamine produces rapid antidepressant effects in adolescents with major depressive disorder (MDD), focusing on structural changes in the rostral anterior cingulate cortex (rACC) and associated molecular pathways.</p><p><strong>Method: </strong>A total of 49 adolescents (13-18 years of age) with DSM-5 MDD were randomized to receive intravenous esketamine (0.25 mg/kg) or midazolam (0.02 mg/kg) over 5 days (3 infusions total) and were compared with 25 age-matched healthy controls. Structural magnetic resonance imaging scans were obtained at baseline and 24 hours post treatment to assess bilateral rACC surface area, volume, and thickness using FreeSurfer. Clinical symptoms were evaluated using the Hamilton Depression Rating Scale and Columbia-Suicide Severity Rating Scale. Transcriptomic-neuroimaging coupling analyses were performed using partial least squares regression on Allen Human Brain Atlas data, followed by gene set enrichment and protein-protein interaction analyses.</p><p><strong>Results: </strong>At baseline, adolescents with MDD showed increased right rACC surface area compared with healthy controls (Cohen d = 0.47, 95% CI = 0.08, 1.02, p = .020). Following esketamine treatment, right rACC surface area decreased to levels comparable to those of healthy controls (Cohen d = 0.17, 95% CI = -0.41, 0.75, p = .523), showing a significant group by time interaction (F<sub>1,47</sub> = 8.06, partial η<sup>2</sup> = 0.15, p = .006). In the esketamine group, greater reductions in right rACC surface area were associated with larger decreases in Hamilton Depression Rating Scale scores (r = -0.44, 95% CI = -0.77, -0.09, p = .040). Partial least-squares regression analysis identified a brain-gene coupling component (r = 0.44, p = .008; p_spin = .018) enriched for pathways related to mitochondrial energy metabolism (oxidative phosphorylation: normalized enrichment score = 5.66, false discovery rate <0.001; tricarboxylic acid cycle: normalized enrichment score = 5.33, false discovery rate <0.001). Protein-protein interaction network analysis highlighted electron transport chain complexes I and V as central modules.</p><p><strong>Conclusion: </strong>Esketamine rapidly reduced elevated right rACC surface area in adolescents with MDD, and this structural change correlated with clinical improvement. Moreover, enhanced mitochondrial function-particularly oxidative phosphorylation and electron transport chain activity-may contribute to these structural and clinical effects, providing insight into the mechanisms underlying esketamine's antidepressant action.</p><p><strong>Clinical trial registration information: </strong>A Study to evaluate the efficacy and safety of Esketamine combined with oral antidepressants in the treatment of major depressive disorder with suicidal ideation; https://www.chictr.org.cn/showproj.html?proj=66172 DIVERSITY & INCLUSION STATEMENT: We worked
目的:探讨艾氯胺酮对青少年重度抑郁症(MDD)产生快速抗抑郁作用的神经生物学机制,重点研究吻侧前扣带皮层(rACC)的结构变化及其相关分子通路。方法:49名患有《精神障碍诊断与统计手册》(第5版)的青少年(年龄:13-18岁),随机接受静脉注射艾氯胺酮(0.25 mg/kg)或咪达唑仑(0.02 mg/kg) 5天(共3次),并与25名年龄匹配的健康对照组进行比较。在基线和治疗后24小时进行结构磁共振成像扫描,使用FreeSurfer评估双侧rACC的表面积、体积和厚度。临床症状评估采用汉密尔顿抑郁评定量表和哥伦比亚自杀严重程度评定量表。利用偏最小二乘回归对Allen人脑图谱数据进行转录组-神经成像耦合分析,然后进行基因集富集和蛋白质相互作用分析。结果:在基线时,与健康对照组相比,MDD青少年右rACC表面积增加(Cohen’s d = 0.47, 95%可信区间[0.08,1.02],p = 0.020)。艾氯胺酮治疗后,右rACC表面积下降到与健康对照组相当的水平(Cohen’s d = 0.17, 95%可信区间[-0.41,0.75],p = 0.523),显示出显著的组×时间相互作用(F(1,47) = 8.06,偏η2 = 0.15, p = 0.006)。在艾氯胺酮组中,右侧rACC表面积的较大减少与汉密尔顿抑郁评定量表得分的较大下降相关(r = -0.44, 95%可信区间[-0.77,-0.09],p = 0.040)。偏最小二乘回归分析发现,脑-基因耦合成分(r = 0.44, p = 0.008; p_spin = 0.018)富集于线粒体能量代谢相关途径(氧化磷酸化:归一化富集评分= 5.66,错误发现率< 0.001;三羧酸循环:归一化富集评分= 5.33,错误发现率< 0.001)。蛋白质-蛋白质相互作用网络分析强调电子传递链复合物I和V是中心模块。结论:艾氯胺酮可迅速降低MDD青少年右rACC表面积升高,这种结构变化与临床改善相关。此外,线粒体功能的增强——特别是氧化磷酸化和电子传递链活性——可能有助于这些结构和临床效果,为艾氯胺酮抗抑郁作用的潜在机制提供了见解。
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引用次数: 0
Editorial: We Need More Research on Youth Suicide. 社论:我们需要更多关于青少年自杀的研究。
IF 9.5 1区 医学 Q1 PEDIATRICS Pub Date : 2025-12-30 DOI: 10.1016/j.jaac.2025.12.018
Daniel P Dickstein
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引用次数: 0
Meta-Analysis: Parenting Children and Adolescents with Attention-Deficit/Hyperactivity Disorder Compared to Healthy Controls. 荟萃分析:与健康对照组相比,有注意缺陷/多动障碍的儿童和青少年的养育方式。
IF 9.5 1区 医学 Q1 PEDIATRICS Pub Date : 2025-12-30 DOI: 10.1016/j.jaac.2025.12.016
Tudor Văidean, Anca Dobrean, Elena Predescu, Marie B H Yap, Raluca Diana Georgescu

Objective: This systematic review and meta-analysis aimed to quantify differences in parenting practices between families of children with attention-deficit/hyperactivity disorder (ADHD) and typically developing controls.

Method: We conducted a systematic review and meta-analysis of studies comparing parenting practices among children and adolescents (≤18 years) with a specialist-confirmed ADHD diagnosis and non-clinical controls. PubMed, PsycINFO, Web of Science, and Scopus were searched from inception through August 12, 2025, without language restrictions. Studies were eligible if they used validated instruments to assess at least one parenting dimension and reported comparative data. Sixty-two studies were included (N = 13,105; ADHD = 6,543; controls = 6,562) from 19 countries. We computed pooled standardized mean differences (Hedges' g) using random-effects models and evaluated heterogeneity (Q and I2), 95% prediction intervals, and risk of bias (Newcastle-Ottawa Scale). Meta-regression and subgroup analyses examined potential moderators.

Results: Parents of children with ADHD showed significantly lower levels of positive parenting (g = -0.37, 95% CI -0.46 to -0.27) and higher levels of negative parenting (g = 0.47, 95% CI 0.39 to 0.56) than controls. Strongest effects were found for authoritative parenting (g = -0.56), warmth (g = -0.45), abuse (g = 0.60), family conflict (g = 0.52), and hostility (g = 0.51). Heterogeneity was high (I2 ≥ 90%), and no consistent moderators or small-study effects were identified.

Conclusion: Parenting differs significantly between families of children with and without ADHD. Interventions should promote structured, warm, and non-coercive parenting. High heterogeneity and cross-sectional designs limit causal inference.

目的:本系统综述和荟萃分析旨在量化有注意缺陷多动障碍(ADHD)儿童的家庭与正常发展的对照组之间养育方式的差异。方法:我们对专家确诊ADHD的儿童和青少年(≤18岁)和非临床对照的父母教养做法进行了系统回顾和荟萃分析。PubMed, PsycINFO, Web of Science和Scopus从开始到2025年8月12日进行了搜索,没有语言限制。如果研究使用有效的工具来评估至少一个养育方面并报告比较数据,则研究是合格的。纳入了来自19个国家的62项研究(N = 13,105; ADHD = 6,543;对照= 6,562)。我们使用随机效应模型计算合并标准化平均差异(Hedges’g),并评估异质性(Q和I2)、95%预测区间和偏倚风险(纽卡斯尔-渥太华量表)。元回归和亚组分析检查了潜在的调节因素。结果:与对照组相比,ADHD儿童的父母表现出较低水平的积极父母教养(g = -0.37, 95% CI -0.46至-0.27)和较高水平的消极父母教养(g = 0.47, 95% CI 0.39至0.56)。对权威教养(g = -0.56)、温暖(g = -0.45)、虐待(g = 0.60)、家庭冲突(g = 0.52)和敌意(g = 0.51)的影响最大。异质性高(I2≥90%),未发现一致的调节因子或小研究效应。结论:ADHD患儿家庭与非ADHD患儿家庭的教养方式存在显著差异。干预措施应促进有组织的、温暖的和非强制性的养育。高异质性和横断面设计限制了因果推断。
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引用次数: 0
Child and Youth Artwork 儿童及青少年艺术作品
IF 9.5 1区 医学 Q1 PEDIATRICS Pub Date : 2025-12-26 DOI: 10.1016/S0890-8567(25)02125-2
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引用次数: 0
Editors’ Best of 2025 2025年最佳编辑
IF 9.5 1区 医学 Q1 PEDIATRICS Pub Date : 2025-12-26 DOI: 10.1016/j.jaac.2025.10.011
Douglas K. Novins MD, Robert R. Althoff MD, PhD, Melissa A. Brotman PhD, Melissa P. DelBello MD, Alysa E. Doyle PhD, Lisa R. Fortuna MD, MPH, MDiv, Mary A. Fristad PhD, ABPP, Christel M. Middeldorp MD, PhD, Wanjikũ F.M. Njoroge MD, Cynthia E. Rogers MD, Manpreet Kaur Singh MD, MS
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引用次数: 0
Hats Off: Journal Awards 2025 脱帽致敬:2025年期刊奖
IF 9.5 1区 医学 Q1 PEDIATRICS Pub Date : 2025-12-26 DOI: 10.1016/j.jaac.2025.10.009
Douglas K. Novins MD (Editor-in-Chief), Tami D. Benton MD (President, American Academy of Child and Adolescent Psychiatry), Tonya White MD, PhD, Tony T. Yang MD, PhD (2024 Award Winners)
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引用次数: 0
期刊
Journal of the American Academy of Child and Adolescent Psychiatry
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