Pub Date : 2026-01-22DOI: 10.1016/j.jfma.2026.01.047
Shangshang Wang, Wenrou Chen, Danhong Yang
{"title":"Comment on \"Utilization and stakeholder perspectives on traditional Chinese medicine in Taiwan's integrated home-based medical care: a mixed-methods study\".","authors":"Shangshang Wang, Wenrou Chen, Danhong Yang","doi":"10.1016/j.jfma.2026.01.047","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.047","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.jfma.2026.01.037
Yi-Song Huang, Shu-Zhen Fang
{"title":"Durable outcomes with Atezo-Bev: Uncovering predictors and unmet needs in advanced liver cancer.","authors":"Yi-Song Huang, Shu-Zhen Fang","doi":"10.1016/j.jfma.2026.01.037","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.037","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.jfma.2026.01.038
Gang Chen
{"title":"Decoding the hemoglobin-RDW crosstalk: HRR as a low-cost predictor of fragility fracture.","authors":"Gang Chen","doi":"10.1016/j.jfma.2026.01.038","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.038","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1016/j.jfma.2026.01.036
Tu Thai Bao Nguyen, Yi-Jie Kuo, Quang Son Tran, Yu-Pin Chen
{"title":"Response to \"Red cell distribution width in geriatric hip fracture: Integrating biomarkers for refined prognostic stratification and clinical decision making\".","authors":"Tu Thai Bao Nguyen, Yi-Jie Kuo, Quang Son Tran, Yu-Pin Chen","doi":"10.1016/j.jfma.2026.01.036","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.036","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.jfma.2026.01.034
Ning Ding, Xiaoyan Ma
{"title":"Comment on \"Risk factors for incident or persistent SARC-F-defined sarcopenia in patients with end-stage kidney disease: a cohort study\".","authors":"Ning Ding, Xiaoyan Ma","doi":"10.1016/j.jfma.2026.01.034","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.034","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.jfma.2026.01.041
Juanli Lv, Huihui Zhu
{"title":"Beyond one size fits all: Towards BMI specific gestational weight gain guidelines for Asian women.","authors":"Juanli Lv, Huihui Zhu","doi":"10.1016/j.jfma.2026.01.041","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.041","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.jfma.2026.01.048
Sha-Sha Zhu, Zhi-Min Wang, Lian-Ping He
{"title":"Healing where you live: The trend of home-based TCM in Taiwan-stakeholder voices and systemic shifts.","authors":"Sha-Sha Zhu, Zhi-Min Wang, Lian-Ping He","doi":"10.1016/j.jfma.2026.01.048","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.048","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.jfma.2026.01.042
Guan-Jhou Chen, Miao-Hui Huang, Chien-Ching Hung
{"title":"Sexual transmission of HCV should not be overlooked among MSM without HIV infection.","authors":"Guan-Jhou Chen, Miao-Hui Huang, Chien-Ching Hung","doi":"10.1016/j.jfma.2026.01.042","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.042","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.jfma.2026.01.045
Haonan Jin
{"title":"Comment on \"Optimizing maternal weight gain to improve neonatal Health: A nationwide birth cohort analysis in Taiwan\".","authors":"Haonan Jin","doi":"10.1016/j.jfma.2026.01.045","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.045","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: and purpose: Delta-like 1 homologue (DLK1), a transmembrane and secreted protein, is a non-canonical Notch ligand. DLK1 is also a hepatic stem/progenitor cell marker in both fetal liver and hepatocellular carcinoma (HCC). However, the role of DLK1 in HCC remains incompletely characterized.
Methods: We examined DLK1 expression patterns in 90 HCC specimens and paired adjacent non-tumorous liver tissues after surgical resection by using immunoblot analysis, and investigated their associations with clinicopathological parameters. The oncogenic functions of DLK1 were also analyzed in vitro.
Results: DLK1 protein levels were significantly upregulated in HCC tissues compared to adjacent normal liver tissues in about 36/90 (40 %) of patients, and high DLK1 expression in tumor was associated with shorter overall and disease-free survivals. Moreover, DLK1 expression in HCC tissues positively correlated with advanced BCLC stages and big tumor sizes. Subsequent in vitro experiments demonstrated that recombinant DLK1 (rDLK1) protein, markedly promoted the proliferation of hepatoma cells. Furthermore, genetic manipulation of cellular DLK1 levels regulates the proliferation and colonies formation of HCC cells in vitro.
Conclusion: Our findings suggest that elevated DLK1 expression in HCC is linked to advanced BCLC stages, big tumor sizes and poor prognosis in HCC patients after surgical resection. DLK1 seems to serve as a valuable biomarker and may be a candidate for therapeutic targeting of HCC pending further validation.
{"title":"Delta-like 1 homologue (DLK1) predicts clinical outcomes in patients with hepatocellular carcinoma.","authors":"Kuan-Fu Huang, Tian-Huei Chu, Kuo-Chin Chang, Cheng-Kun Wu, Ming-Chao Tsai, Chao-Cheng Huang, Tsung-Hui Hu, Ming-Hong Tai","doi":"10.1016/j.jfma.2026.01.022","DOIUrl":"https://doi.org/10.1016/j.jfma.2026.01.022","url":null,"abstract":"<p><strong>Background: </strong>and purpose: Delta-like 1 homologue (DLK1), a transmembrane and secreted protein, is a non-canonical Notch ligand. DLK1 is also a hepatic stem/progenitor cell marker in both fetal liver and hepatocellular carcinoma (HCC). However, the role of DLK1 in HCC remains incompletely characterized.</p><p><strong>Methods: </strong>We examined DLK1 expression patterns in 90 HCC specimens and paired adjacent non-tumorous liver tissues after surgical resection by using immunoblot analysis, and investigated their associations with clinicopathological parameters. The oncogenic functions of DLK1 were also analyzed in vitro.</p><p><strong>Results: </strong>DLK1 protein levels were significantly upregulated in HCC tissues compared to adjacent normal liver tissues in about 36/90 (40 %) of patients, and high DLK1 expression in tumor was associated with shorter overall and disease-free survivals. Moreover, DLK1 expression in HCC tissues positively correlated with advanced BCLC stages and big tumor sizes. Subsequent in vitro experiments demonstrated that recombinant DLK1 (rDLK1) protein, markedly promoted the proliferation of hepatoma cells. Furthermore, genetic manipulation of cellular DLK1 levels regulates the proliferation and colonies formation of HCC cells in vitro.</p><p><strong>Conclusion: </strong>Our findings suggest that elevated DLK1 expression in HCC is linked to advanced BCLC stages, big tumor sizes and poor prognosis in HCC patients after surgical resection. DLK1 seems to serve as a valuable biomarker and may be a candidate for therapeutic targeting of HCC pending further validation.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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