Pub Date : 2025-12-20DOI: 10.1016/j.jfma.2025.12.007
Juanli Lv, Huihui Zhu
{"title":"Pembrolizumab in advanced endometrial cancer: Dosing equivalence and molecular insights from an Asian cohort.","authors":"Juanli Lv, Huihui Zhu","doi":"10.1016/j.jfma.2025.12.007","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.007","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.jfma.2025.12.028
Teng Wang, Xiaofei Li
{"title":"The unresolved link between MASLD and long-term ferritin dynamics in HCV-cured patients.","authors":"Teng Wang, Xiaofei Li","doi":"10.1016/j.jfma.2025.12.028","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.028","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.jfma.2025.12.031
Yu-Jie Huang, Shang-Yu Chou, Yan-Ye Su, Wen-Ling Tsai, Fu-Min Fang
{"title":"Reply to comment on \"Prospective longitudinal study of patient-reported dysphagia in nasopharyngeal carcinoma treated with intensity-modulated proton therapy\".","authors":"Yu-Jie Huang, Shang-Yu Chou, Yan-Ye Su, Wen-Ling Tsai, Fu-Min Fang","doi":"10.1016/j.jfma.2025.12.031","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.031","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.jfma.2025.12.030
Chih-Chieh Yu, An-Li Yu
{"title":"Response to comment on \"Left atrial reservoir strain as a surrogate marker for atrial fibrillation burden in patients with non-valvular atrial fibrillation\".","authors":"Chih-Chieh Yu, An-Li Yu","doi":"10.1016/j.jfma.2025.12.030","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.030","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.jfma.2025.12.035
Jianan Zhang
{"title":"Does Pre-DAA NLR truly add no value to FIB-4 for predicting Post-SVR liver complications in HCV patients.","authors":"Jianan Zhang","doi":"10.1016/j.jfma.2025.12.035","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.035","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.jfma.2025.12.025
Shaoxuan Wei, Yixuan Ma, Nan Zhang, Lu Guo, Wenchao Yao, Xiaoli Hou, Haibing Li, Bing Zhang, Liu Zhang, Lei Xing, Jingyuan Gao, Shouling Wu, Faming Tian
Purpose: To evaluate the prospective association between the hemoglobin-to-red blood cell distribution width ratio (HRR) and the incidence of fragility fractures in a general Chinese population.
Methods: A prospective cohort of 80,515 Chinese adults (mean age: 52.1 years, 79.6 % men) was followed from 2006 to 2023. HRR was calculated as hemoglobin divided by red cell distribution width and categorized into quartiles. The incident fragility fractures were identified via medical records. Cox-proportional hazards models were employed to assess the association between HRR and fracture risk, adjusting for demographics, lifestyle factors, clinical measurements, and medication use. Multiple sensitivity analyses were used to verify the robustness of the results.
Results: Over a mean follow-up of 15.6 years, 1730 participants sustained fragility fractures. Higher HRR was associated with a lower fracture risk. In fully adjusted models, the highest HRR quartile had a 19 % lower risk than the lowest (HR 0.81, 95 % CI 0.70-0.94; P-trend <0.05). Each one SD increase in HRR corresponded to a 7 % reduction in fracture risk (HR 0.93, 95 % CI 0.88-0.97). The inverse association was significant in men and those aged <60 years, but not in women or in individuals aged >60 years. The findings remained robust in sensitivity analyses and competing-risk models.
Conclusion: This large-scale study is the first to demonstrate a significant inverse association between HRR and fragility fracture risk. HRR remained an independent protective factor after multivariable adjustment, and, as a simple, low-cost inflammatory biomarker, it demonstrates potential for early identification and risk stratification of high-risk individuals.
目的：评估中国普通人群中血红蛋白与红细胞分布宽度比（HRR）与脆性骨折发生率之间的前瞻性关联。方法：从2006年到2023年，对80,515名中国成年人（平均年龄：52.1岁，79.6%为男性）进行前瞻性队列研究。HRR的计算方法是血红蛋白除以红细胞分布宽度，并分为四分位数。事故脆性骨折是通过医疗记录确定的。采用cox比例风险模型评估HRR与骨折风险之间的关系，并对人口统计学、生活方式因素、临床测量和药物使用进行调整。采用多重敏感性分析验证结果的稳健性。结果：在平均15.6年的随访中，1730名参与者出现脆性骨折。HRR越高，骨折风险越低。在完全调整后的模型中，HRR最高的四分位数比最低的四分位数的风险低19% （HR 0.81, 95% CI 0.70-0.94； p趋势60年）。这些发现在敏感性分析和竞争风险模型中仍然是可靠的。结论：这项大规模研究首次证明了HRR与脆性骨折风险之间存在显著的负相关关系。在多变量调整后，HRR仍然是一个独立的保护因素，作为一种简单、低成本的炎症生物标志物，它显示了早期识别和高风险个体风险分层的潜力。
{"title":"Hemoglobin-to-red blood cell distribution width ratio and risk of fragility fracture: A 16-year prospective cohort study.","authors":"Shaoxuan Wei, Yixuan Ma, Nan Zhang, Lu Guo, Wenchao Yao, Xiaoli Hou, Haibing Li, Bing Zhang, Liu Zhang, Lei Xing, Jingyuan Gao, Shouling Wu, Faming Tian","doi":"10.1016/j.jfma.2025.12.025","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.025","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the prospective association between the hemoglobin-to-red blood cell distribution width ratio (HRR) and the incidence of fragility fractures in a general Chinese population.</p><p><strong>Methods: </strong>A prospective cohort of 80,515 Chinese adults (mean age: 52.1 years, 79.6 % men) was followed from 2006 to 2023. HRR was calculated as hemoglobin divided by red cell distribution width and categorized into quartiles. The incident fragility fractures were identified via medical records. Cox-proportional hazards models were employed to assess the association between HRR and fracture risk, adjusting for demographics, lifestyle factors, clinical measurements, and medication use. Multiple sensitivity analyses were used to verify the robustness of the results.</p><p><strong>Results: </strong>Over a mean follow-up of 15.6 years, 1730 participants sustained fragility fractures. Higher HRR was associated with a lower fracture risk. In fully adjusted models, the highest HRR quartile had a 19 % lower risk than the lowest (HR 0.81, 95 % CI 0.70-0.94; P-trend <0.05). Each one SD increase in HRR corresponded to a 7 % reduction in fracture risk (HR 0.93, 95 % CI 0.88-0.97). The inverse association was significant in men and those aged <60 years, but not in women or in individuals aged >60 years. The findings remained robust in sensitivity analyses and competing-risk models.</p><p><strong>Conclusion: </strong>This large-scale study is the first to demonstrate a significant inverse association between HRR and fragility fracture risk. HRR remained an independent protective factor after multivariable adjustment, and, as a simple, low-cost inflammatory biomarker, it demonstrates potential for early identification and risk stratification of high-risk individuals.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-18DOI: 10.1016/j.jfma.2025.12.026
Yuanxia Li, Shuyan Liu
{"title":"Comment on \"Left atrial reservoir strain as a surrogate marker for atrial fibrillation burden in patients with non-valvular atrial fibrillation\".","authors":"Yuanxia Li, Shuyan Liu","doi":"10.1016/j.jfma.2025.12.026","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.026","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-17DOI: 10.1016/j.jfma.2025.12.029
Yu-Ping Chang, Jia-Horng Kao, Chen-Hua Liu
{"title":"Response to \"The unresolved link between MASLD and long-term ferritin dynamics in HCV-cured patients\".","authors":"Yu-Ping Chang, Jia-Horng Kao, Chen-Hua Liu","doi":"10.1016/j.jfma.2025.12.029","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.029","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for neonates with refractory respiratory failure. However, outcomes and associated risk factors in Taiwanese population are lacking.
Methods: This single-center retrospective cohort study recruited all neonates who received ECMO support for respiratory failure in our institute from 2009 to 2023. The primary outcome was the survival to hospital discharge. The secondary outcome was favorable neurological outcome. Demographic data, indications, management, and laboratory data were compared between survived and non-survived groups to identify factors associated with outcomes.
Results: Forty-eight patients were enrolled in this study and 23 (48 %) survived to hospital discharge. Among survived patients, 20 (42 %) had favorable neurological outcomes. One year survival was 40 %. Comparisons between the survived group and the non-survived found that factors associated with overall mortality included premature birth (hazard ratio, 2.77), low birth weight (hazard ratio, 2.67), bicarbonate level <20 mmol/L 24 h after ECMO initiation (hazard ratio, 3.75), and need of renal replacement therapy (hazard ratio, 4.01). Multivariate analysis identified low birth weight and requirement for renal replacement therapy as independent risk factors for mortality.
Conclusion: The survival rate after ECMO support for neonates with respiratory failure in this cohort is 48 %. Low birth weight and the requirement for renal replacement therapy are associated with mortality.
{"title":"Clinical characteristics and outcomes in neonates with respiratory failure requiring venoarterial extracorporeal membrane oxygenation support in Taiwan.","authors":"Ying-Hao Yu, Heng-Wen Chou, Chien-Heng Lai, Ching-Chia Wang, Frank Leigh Lu, Po-Nien Tsao, Chih-Hsien Wang, Shu-Chien Huang, Yih-Sharng Chen, En-Ting Wu","doi":"10.1016/j.jfma.2025.12.017","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.017","url":null,"abstract":"<p><strong>Background: </strong>Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for neonates with refractory respiratory failure. However, outcomes and associated risk factors in Taiwanese population are lacking.</p><p><strong>Methods: </strong>This single-center retrospective cohort study recruited all neonates who received ECMO support for respiratory failure in our institute from 2009 to 2023. The primary outcome was the survival to hospital discharge. The secondary outcome was favorable neurological outcome. Demographic data, indications, management, and laboratory data were compared between survived and non-survived groups to identify factors associated with outcomes.</p><p><strong>Results: </strong>Forty-eight patients were enrolled in this study and 23 (48 %) survived to hospital discharge. Among survived patients, 20 (42 %) had favorable neurological outcomes. One year survival was 40 %. Comparisons between the survived group and the non-survived found that factors associated with overall mortality included premature birth (hazard ratio, 2.77), low birth weight (hazard ratio, 2.67), bicarbonate level <20 mmol/L 24 h after ECMO initiation (hazard ratio, 3.75), and need of renal replacement therapy (hazard ratio, 4.01). Multivariate analysis identified low birth weight and requirement for renal replacement therapy as independent risk factors for mortality.</p><p><strong>Conclusion: </strong>The survival rate after ECMO support for neonates with respiratory failure in this cohort is 48 %. Low birth weight and the requirement for renal replacement therapy are associated with mortality.</p>","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jfma.2025.12.008
Zhongxia Wang
{"title":"Comment on \"Development and validation of machine learning models for mortality risk stratification in acute pancreatitis patients complicated by acute kidney injury\".","authors":"Zhongxia Wang","doi":"10.1016/j.jfma.2025.12.008","DOIUrl":"https://doi.org/10.1016/j.jfma.2025.12.008","url":null,"abstract":"","PeriodicalId":17305,"journal":{"name":"Journal of the Formosan Medical Association","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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