Journal of the Renin-Angiotensin-Aldosterone System最新文献_第10页

Treatment of Essential Hypertension with Emphasis in the Renin-Angiotensin System: How to Prevent Secondary Outcomes without Adding Fuel to the Fire 以肾素-血管紧张素系统为重点治疗原发性高血压:如何在不火上浇油的情况下预防继发性结局

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-18 DOI: 10.5772/INTECHOPEN.86853

G. L. Salvador

The effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blocker AT-1 (ARBs) in reducing the systemic hypertension (SH) is widely known. However their comparative outcomes resulting from prolonged use remain unknown. The objective of this chapter is to discuss the evidence of prospective randomized double-blind clinical trials; all the events result from prolonged use of ACEIs or ARBs in hypertensive patients. In lowering blood pressure, the use of ACE inhibitors or ARBs reduces, in long-term use, the risk of acute myocardial infarction, stroke, and heart failure. However, the use of ACEIs is effective in an overall quantitative analysis; the total mortality regarding cardiovascular causes an outcome that was not observed with the use of ARBs. This fact is assumed to be related to the higher plasma concentration of bradykinin in the use of ACEIs, a well-known cardiovascular-protective factor.

血管紧张素转换酶抑制剂(ACEIs)和血管紧张素II受体阻滞剂AT-1 (ARBs)在降低全体性高血压(SH)方面的有效性已广为人知。然而，长期使用的比较结果尚不清楚。本章的目的是讨论前瞻性随机双盲临床试验的证据;所有这些事件都是由于高血压患者长期使用acei或arb所致。在降低血压方面，长期使用ACE抑制剂或arb可降低急性心肌梗死、中风和心力衰竭的风险。但是，在总体定量分析中使用经济效益指数是有效的;与心血管原因相关的总死亡率，这是使用arb时未观察到的结果。这一事实被认为与使用acei时血浆缓激肽浓度较高有关，这是一种众所周知的心血管保护因子。

引用次数: 0

From Angiotensin to Renin to Prorenin and from the Adrenal to the Kidney to the Placenta and the Lungs: An Historical Journey 从血管紧张素到肾素再到原肾素，从肾上腺到肾脏再到胎盘和肺:一个历史的旅程

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-17 DOI: 10.5772/INTECHOPEN.87041

A. Poisner

In 1966 I carried out a study on the role of calcium on angiotensin’s stimulant effects on the adrenal medulla. Since then I have been studying the renin-angiotensin system (RAS) for over a half-century in a wide variety of biological preparations, while awareness of its complexity has exploded. My journey has involved studies on genes, proteins, organelles, cells, tissues, glands, organs and whole animals. This chapter reviews what my colleagues and I have learned from these different levels of organization and is not meant to be an update on all features of the RAS. My studies have included experiments on: perfused cat adrenal glands; genetic and second messenger control of catecholamine synthesis and secretion from cultured bovine chromaffin cells and from rats in vivo; renin storage and release in the rat kidney and secretory granules; properties of isolated renin, prorenin and renin-like proteins; hormonal and second messenger control of prorenin secretion from human utero-placental tissues; renin/prorenin in a variety of tumors; and the effect of RAS drugs in a rodent model of pulmonary fat embolism. This most recent study has direct clinical application. I conclude with what I have learned about biomedical research and lessons for the future.

1966年，我进行了一项关于钙在血管紧张素对肾上腺髓质的刺激作用中的作用的研究。从那时起，我一直在研究肾素血管紧张素系统(RAS)半个多世纪，在各种各样的生物制剂中，同时对其复杂性的认识也在爆炸。我的旅程涉及基因、蛋白质、细胞器、细胞、组织、腺体、器官和整个动物的研究。本章回顾了我和我的同事从这些不同层次的组织中学到的东西，并不是要更新RAS的所有特征。我的研究包括:灌注猫肾上腺的实验;体外培养的牛和大鼠嗜铬细胞合成和分泌儿茶酚胺的遗传和第二信使调控肾素在大鼠肾脏和分泌颗粒中的储存和释放;分离肾素、原肾素和肾素样蛋白的性质人子宫胎盘组织泌乳素分泌的激素和第二信使调控肾素/原肾素在多种肿瘤中的表达;以及RAS药物对小鼠肺脂肪栓塞模型的影响。这项最新的研究有直接的临床应用。最后，我总结了我对生物医学研究的了解和对未来的教训。

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引用次数: 0

Effects of telmisartan and losartan treatments on bone turnover markers in patients with newly diagnosed stage I hypertension 替米沙坦和氯沙坦治疗对新诊断I期高血压患者骨转换标志物的影响

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-01 DOI: 10.1177/1470320319862741

B. I. Aydoğan, Emrah Erarslan, U. Ünlütürk, S. Güllü

Introduction: Telmisartan is an angiotensin-II receptor type-1 blocker and a partial agonist for peroxisome proliferator-activated receptor-γ. The aim of this study was to determine the potential effects of telmisartan on bone metabolism and turnover markers. Methods: Forty-two patients with newly diagnosed stage I hypertension who were prescribed telmisartan 80 mg/day or losartan 100 mg/day were included. Serum levels of calcium, phosphorus, 25-hydroxy vitamin D, bone-specific alkaline phosphatase, osteocalcin, interleukin 6 and 24-hour urinary N-terminal telopeptide were measured at the beginning and after 12 weeks of treatment. Results: When treatment arms were evaluated together, significantly increased 25-hydroxy vitamin D levels (p=0.01), and decreased parathormone (PTH) (p<0.001), bone-specific alkaline phosphatase (p=0.01), osteocalcin (p=0.045), urinary N-terminal telopeptide (p<0.001) and interleukin 6 levels (p=0.006) were observed. After eliminating the 25-hydroxy vitamin D effect, significant changes were not observed at any of the parameters. None of the levels of parameters were different between groups. Conclusions: Neither telmisartan, despite its partial peroxisome proliferator-activated receptor-γ agonistic effect, nor losartan treatment had significant effects on bone turnover markers in newly diagnosed stage I hypertensive patients.

替米沙坦是一种血管紧张素- ii受体1型阻滞剂和过氧化物酶体增殖激活受体-γ的部分激动剂。本研究的目的是确定替米沙坦对骨代谢和代谢标志物的潜在影响。方法:采用替米沙坦80 mg/d或氯沙坦100 mg/d治疗的新诊断I期高血压患者42例。在治疗开始和治疗12周后测定血清钙、磷、25-羟基维生素D、骨特异性碱性磷酸酶、骨钙素、白细胞介素6和24小时尿n端端肽水平。结果:各治疗组合并评估时，25-羟基维生素D水平显著升高(p=0.01)，甲状旁腺激素(PTH) (p<0.001)、骨特异性碱性磷酸酶(p=0.01)、骨钙素(p=0.045)、尿n端端肽(p<0.001)和白细胞介素6 (p=0.006)水平显著降低。在排除了25-羟基维生素D的影响后，在任何参数上都没有观察到显著的变化。各组间各项参数水平均无差异。结论:尽管替米沙坦具有部分过氧化物酶体增殖物激活受体-γ激动作用，但氯沙坦治疗对新诊断的I期高血压患者骨转换标志物均无显著影响。

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引用次数: 6

Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study 他汀类药物联合ACE抑制剂治疗对原发性高血压患者内皮功能和血压的影响——一项随机、双盲、安慰剂对照交叉研究

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-01 DOI: 10.1177/1470320319868890

P. Ruszkowski, Anna Masajtis-Zagajewska, M. Nowicki

Background: The aim of this study was to compare the influence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on endothelial function and blood pressure in patients with essential hypertension on long-term angiotensin-converting enzyme inhibitor therapy. Method: The study was designed as a prospective, double-blind, randomised, placebo controlled, crossover clinical trial. Twenty patients with essential hypertension were treated with an angiotensin-converting enzyme inhibitor; the control group included 10 healthy subjects. Hypertensive patients received in random order 80 mg of fluvastatin daily or placebo for 6 weeks. The following parameters were assessed at baseline and after each treatment period: serum lipids, flow-mediated vasodilation, activity of von Willebrand factor, concentration of vascular endothelial growth factor, C-reactive protein and 24-hour blood pressure profile. Results: Hypertensive patients did not differ from healthy subjects with respect to age, body mass and biochemical parameters, with the exception of C-reactive protein, which was higher in hypertensive patients (P=0.02). After statin therapy, low-density lipoprotein cholesterol (P<0.0001), C-reactive protein (P=0.03), von Willebrand factor (P=0.03) and vascular endothelial growth factor (P<0.01) decreased and flow-mediated vasodilation improved (P<0.001). Statins had no significant effect on blood pressure. Conclusions: Statins added to angiotensin-converting enzyme inhibitors may improve endothelial function and ameliorate inflammation independently of blood pressure.

背景:本研究的目的是比较长期血管紧张素转换酶抑制剂治疗3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂对原发性高血压患者内皮功能和血压的影响。方法:采用前瞻性、双盲、随机、安慰剂对照的交叉临床试验。用血管紧张素转换酶抑制剂治疗20例原发性高血压患者;对照组为10名健康受试者。高血压患者随机接受每日80mg氟伐他汀或安慰剂治疗，持续6周。在基线和每个治疗期后评估以下参数:血脂、血流介导的血管舒张、血管性血变因子活性、血管内皮生长因子浓度、c反应蛋白和24小时血压。结果:高血压患者在年龄、体重、生化指标等方面与健康者无显著差异，但c反应蛋白高于高血压患者(P=0.02)。他汀类药物治疗后，低密度脂蛋白胆固醇(P<0.0001)、c反应蛋白(P=0.03)、血管性血变因子(P=0.03)和血管内皮生长因子(P<0.01)降低，血流介导的血管舒张改善(P<0.001)。他汀类药物对血压没有显著影响。结论:他汀类药物加入血管紧张素转换酶抑制剂可以改善内皮功能和改善炎症，而不依赖于血压。

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引用次数: 15

No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake. 血管紧张素受体阻滞剂坎地沙坦对高钠和低钠大鼠脑血管自动调节无影响。

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-01 DOI: 10.1177/1470320319874615

Sigurdur T Sigurdsson, Peter Bie, Arne H Nielsen, Svend Strandgaard, Olaf B Paulson

Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin-angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na⁺) and low (0.004% Na⁺) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level.

脑血流的自动调节(CBF)表明，尽管血压在很大范围内波动，但CBF是恒定的。已知抑制肾素-血管紧张素系统(RAS)可降低CBF自动调节的下限和上限。我们之前的研究表明，这包括血管紧张素受体阻滞剂坎地沙坦的抑制作用。在本研究中，我们研究了ARB坎地沙坦对两组高钠(4.0% Na+)和低钠(0.004% Na+)饮食的Sprague-Dawley大鼠CBF自动调节下限的影响。对照组动物给予相同的饮食，但不给予ARB。用激光多普勒法研究脑血流。控制出血降低了血压。结果表明，高钠和低钠饮食、低肾素和高肾素水平分别阻断坎地沙坦对CBF自动调节的影响。这在高盐饮食和低肾素水平的大鼠中是意料之中的，但在低盐饮食和高肾素水平的大鼠中却出乎意料。

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引用次数: 0

The characteristics of captopril challenge test–positive patients using various criteria 卡托普利挑战试验阳性患者的特点

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-01 DOI: 10.1177/1470320319870891

Satoshi Kidoguchi, Naoki Sugano, Naomi Hayashi-Ishikawa, Norihiko Morisawa, Goro Tokudome, T. Yokoo

Introduction: The captopril challenge test (CCT) is the major confirmatory test for primary aldosteronism (PA), and frequently carried out because of its convenience. However, it presents false-negative results with a certain probability, and as there are many criteria for CCT, it is not concluded yet which criteria to use. Materials and methods: A total of 71 PA patients were evaluated. We compared CCT-positive and CCT-negative patients in the following three criteria: plasma aldosterone/renin ratio (ARR) >200 after the CCT (criterion 1); plasma aldosterone concentration (PAC) >120 pg/ml after the CCT (criterion 2); and PAC suppression <30% of PAC before CCT (criterion 3). Results: The positive rate was 70.4%, 64.8% and 54.9% for criterion 1, criterion 2 and criterion 3, respectively. With criterion 1, the baseline plasma renin activity was lower, thus baseline ARR was higher in CCT-positive patients. With criterion 2, PAC was higher and estimated sodium intake and K were lower in CCT-positive patients. With criterion 3, K and PAC were lower in CCT-positive patients. Although it was not significant, in the patients with high sodium intake, the positive rate of criterion 1 was higher than that of the other criteria. Conclusions: ARR>200 is the valuable criterion for the diagnosis of PA.

卡托普利激发试验(CCT)是原发性醛固酮增多症(PA)的主要确诊试验，因其方便而经常进行。但是，它有一定的概率出现假阴性结果，而且由于CCT的标准很多，目前还没有确定使用哪个标准。材料与方法:对71例PA患者进行评估。我们比较了CCT阳性和CCT阴性患者的以下三个标准:CCT后血浆醛固酮/肾素比值(ARR) >200(标准1);CCT后血浆醛固酮浓度(PAC) > 120pg /ml(标准2);PAC抑制200是诊断PA的有价值的标准。

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引用次数: 3

ACE insertion/deletion genetic polymorphism, serum ACE levels and high dietary salt intake influence the risk of obesity development among the Saudi adult population ACE插入/缺失基因多态性、血清ACE水平和高饮食盐摄入量影响沙特成年人群肥胖发展的风险

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-07-01 DOI: 10.1177/1470320319870945

J. Sabir, A. Omri, Imran Ali Khan, B. Banaganapalli, N. Hajrah, Houda Zrelli, A. M. Omar, M. Alharbi, Alawiah M. Alhebshi, R. Jansen, A. Altaf, N. Shaik, Muhummadh Khan

Introduction: Angiotensin-converting enzyme (ACE), which contributes to adipocyte growth, differentiation and function, has recently been linked with both salt metabolism and obesity development. Therefore, this study has aimed to investigate the putative relationship between ACE genetic polymorphism, serum ACE levels and salt consumption on the risk of developing obesity in the Saudi population. Materials and methods: ACE genotype status of 267 adult Saudi volunteers (124 obese and 143 non-obese) was correlated with their serum ACE activity and dietary salt intake amounts. Results: Obesity was more prevalent in deletion-deletion genotype individuals (p<0.03), under dominant, co-dominant and monoallelic conditions (p<0.04). Deletion allele corresponds to serum ACE activity in obese patients (p<0.05). The amount of salt intake (<6 g/d) was significantly associated with obesity and particularly high in deletion-deletion and insertion-deletion genotype carriers (p<0.001). STITCH analysis underlined interactions of the ACE protein with sodium molecule, REN, ACE2, KNG1 and AGTR1 in a biological network. Conclusions: Our findings suggest the positive association between ACE deletion genotype, serum ACE activity and sodium intake with risk of obesity development in the Saudi population.

血管紧张素转换酶(ACE)，有助于脂肪细胞的生长、分化和功能，最近被认为与盐代谢和肥胖的发展有关。因此，本研究旨在探讨沙特人群中ACE基因多态性、血清ACE水平和盐摄入量与肥胖风险之间的可能关系。材料与方法:267名沙特成年志愿者(124名肥胖，143名非肥胖)的ACE基因型状况与血清ACE活性和膳食盐摄入量相关。结果:肥胖在缺失-缺失基因型个体中更为普遍(p<0.03)，在显性、共显性和单等位条件下(p<0.04)。缺失等位基因与肥胖患者血清ACE活性相关(p<0.05)。盐摄入量(<6 g/d)与肥胖显著相关，在缺失-缺失和插入-缺失基因型携带者中尤为显著(p<0.001)。STITCH分析强调了ACE蛋白与钠分子、REN、ACE2、KNG1和AGTR1在生物网络中的相互作用。结论:我们的研究结果表明，在沙特人群中，ACE缺失基因型、血清ACE活性和钠摄入量与肥胖发展风险呈正相关。

{"title":"ACE insertion/deletion genetic polymorphism, serum ACE levels and high dietary salt intake influence the risk of obesity development among the Saudi adult population","authors":"J. Sabir, A. Omri, Imran Ali Khan, B. Banaganapalli, N. Hajrah, Houda Zrelli, A. M. Omar, M. Alharbi, Alawiah M. Alhebshi, R. Jansen, A. Altaf, N. Shaik, Muhummadh Khan","doi":"10.1177/1470320319870945","DOIUrl":"https://doi.org/10.1177/1470320319870945","url":null,"abstract":"Introduction: Angiotensin-converting enzyme (ACE), which contributes to adipocyte growth, differentiation and function, has recently been linked with both salt metabolism and obesity development. Therefore, this study has aimed to investigate the putative relationship between ACE genetic polymorphism, serum ACE levels and salt consumption on the risk of developing obesity in the Saudi population. Materials and methods: ACE genotype status of 267 adult Saudi volunteers (124 obese and 143 non-obese) was correlated with their serum ACE activity and dietary salt intake amounts. Results: Obesity was more prevalent in deletion-deletion genotype individuals (p<0.03), under dominant, co-dominant and monoallelic conditions (p<0.04). Deletion allele corresponds to serum ACE activity in obese patients (p<0.05). The amount of salt intake (<6 g/d) was significantly associated with obesity and particularly high in deletion-deletion and insertion-deletion genotype carriers (p<0.001). STITCH analysis underlined interactions of the ACE protein with sodium molecule, REN, ACE2, KNG1 and AGTR1 in a biological network. Conclusions: Our findings suggest the positive association between ACE deletion genotype, serum ACE activity and sodium intake with risk of obesity development in the Saudi population.","PeriodicalId":17330,"journal":{"name":"Journal of the Renin-Angiotensin-Aldosterone System","volume":"281 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76793625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Connexin-Based Channels and RhoA/ROCK Pathway in Angiotensin II-Induced Kidney Damage 基于连接蛋白的通道和RhoA/ROCK通路在血管紧张素ii诱导的肾损伤中

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-06-22 DOI: 10.5772/INTECHOPEN.87040

G. Gómez, V. Velarde, J. Sáez

The incidence of chronic kidney diseases is increasing worldwide, and there is no efficient therapy to reduce this phenomenon. The main therapies currently available focus on the control of blood pressure and the optimization of the blockade of the renin-angiotensin system (RAS). In addition, it is known that in several models of kidney damage, the amounts of connexins are altered. On the other hand, fasudil, a selective ROCK blocker, has shown renoprotective effects. The beneficial effects of blocking the RhoA/ROCK pathway in renal function may be related to its action of reducing macrophage infiltration, inflammation, and oxidative stress (OS), its expression of extracellular matrix genes and proteinuria, or to its effects on connexin abundance. Even though a correlation has been found between renal damage, caused by an increase in the RAS activity, connexins, and the RhoA/ROCK signaling pathway, it has not yet been possible to clearly determine its functional significance. Moreover, it has not been possible to identify the preponderance of this signaling pathway in the development of chronic kidney diseases. Here, we describe the advances in this subject.

慢性肾脏疾病的发病率在全球范围内呈上升趋势，目前尚无有效的治疗方法来减少这一现象。目前可用的主要治疗方法集中在控制血压和优化肾素-血管紧张素系统(RAS)的封锁。此外，已知在几种肾损伤模型中，连接蛋白的数量发生了改变。另一方面，选择性ROCK阻滞剂法舒地尔显示出肾保护作用。阻断RhoA/ROCK通路对肾功能的有益作用可能与其减少巨噬细胞浸润、炎症和氧化应激(OS)的作用，其细胞外基质基因和蛋白尿的表达，或其对连接蛋白丰度的影响有关。尽管已经发现由RAS活性、连接蛋白增加引起的肾损害与RhoA/ROCK信号通路之间存在相关性，但尚不能明确确定其功能意义。此外，还不可能确定这种信号通路在慢性肾脏疾病的发展中的优势。在这里，我们将描述这一学科的进展。

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引用次数: 3

The impact of At1r inhibition via losartan on the anti-leukaemic effects of doxorubicin in acute myeloid leukaemia. 氯沙坦抑制At1r对阿霉素治疗急性髓性白血病抗白血病作用的影响。

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-04-01 DOI: 10.1177/1470320319851310

Mehdi Ghasemi, Mufide Okay, Seyhan Turk, Ronak Naeemaee, Ebru Guver, Umit Y Malkan, Salih Aksu, Nilgun Sayinalp, Ibrahim C Haznedaroglu

Introduction: Bone marrow renin-angiotensin system(RAS) modulates acute myeloid leukaemia(AML).The aim of this study is to clarify the relationships between RAS and AML, and to show the effect of losartan and doxorubicin treatment in AML cell lines.

Methods: AML cell lines including CESS, HL-60, MO-1, P31/FUJ, GDM-1 and KASUMI-3 were used as models in this study.

Results: After treating the six AML cell lines with a combination of losartan and doxorubicin, they were divided into two groups based on their behaviour: one became more sensitive to drug treatment (Group A) and the other had no change observed in behaviour after drug treatment (Group B). In silico analyses showed that Group A is involved in cellular apoptosis, while Group B is involved in tumour angiogenesis further supporting the in vitro results.

Conclusion: The combined treatment of the AML cell lines with losartan and doxorubicin resulted in an increase in sensitivity of some of the cell lines. Those leukaemic cells are modulated via the induction of apoptosis, whereas the other cells resistant to the drug treatment are closely related to tumour angiogenesis indicating that RAS-AT1R seems to be differently expressed in different leukaemic blast cells and tumour microenvironments. Pharmaco-biological actions of RAS inhibitors may be different in distinct leukaemic cells based on the pathological behaviour of AML genomic subtypes.

骨髓肾素-血管紧张素系统(RAS)调节急性髓性白血病(AML)。本研究的目的是阐明RAS与AML之间的关系，并展示氯沙坦和阿霉素治疗AML细胞系的效果。方法:以CESS、HL-60、MO-1、P31/FUJ、GDM-1、KASUMI-3等AML细胞系为模型。结果:用氯沙坦和阿霉素联合治疗6株AML细胞株后，根据其行为分为两组:一组对药物治疗更加敏感(a组)，另一组在药物治疗后行为无变化(B组)。计算机分析表明，a组参与细胞凋亡，而B组参与肿瘤血管生成，进一步支持了体外研究结果。结论:氯沙坦与阿霉素联合治疗AML细胞系可提高部分细胞系的敏感性。这些白血病细胞通过诱导凋亡被调节，而其他对药物治疗有耐药性的细胞与肿瘤血管生成密切相关，这表明RAS-AT1R似乎在不同的白血病母细胞和肿瘤微环境中表达不同。基于AML基因组亚型的病理行为，RAS抑制剂在不同白血病细胞中的药物生物学作用可能不同。

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引用次数: 5

Reviewers list 审阅人员列表

IF 2.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System

Pub Date : 2019-01-01 DOI: 10.1177/1470320319831142

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Adaya, Ceyla Aguilar, Marie-Isabel Allen, Terri Almeida, Madison Arumugam, Vijaya Barbosa da Silva, Sandra Barwood, Martin Bernardi, Stella Borghi, Claudio Bourgi, Ali Braszko, Jan Canto, Patricia Capewell, Simon Capuccio, Franco Cardillo, Carmine Carlsson, AC Chappell, Mark Danilov, Sergei Delevatti, RS der Groot, Joris Du, Jun-Bao Ekholm, Mikael Erbas, Tomris Ferrario, Carlos Fonseca-Alaniz, MH Fuller, Peter Funder, John Gismondi, Ronaldo Goessler, Karla Gregg, Lucile Gromotowicz-Poplawska, Anna Gros, Robert Hayashi, Kaori Hering, Dagmara Hevia, Vital Ho, Jean Holtzenberg, Maria ISORDIA-SALAS, IRMA Jalil, Jorge Jin, Hongfang Kamei, Motohiro Kosar, Ali Kurlak, Lesi Li, Qifu Liu, Fang-zhou Liu, L Lu, Xifeng MacGregor, Graham Miak, Radoslaw Mohan, Irwin Moraes, Karen Morimoto, Satoshi Murakami, T Narayan, Prakash Ohashi, N Omboni, Stefano Rodriguez, R Roks, Anton Rossi, Gianpaolo Rubio Guerra, Alberto Francisco Säemann, Marcus Saigusa, T Sever, Peter Sharifi, Niura Shenoy, Vinayak Shu, Daisy Siltari, Aino Simao, S Simoes e Silva, Ana Simone, Giuseppe Simonyte, Sandrita Simonyte, Sandrita Song, Ping Stegbauer, Johannes Tain, You-Lin White, Andrew Woo, KT Xue, B Zhao, Qinchum Zhu, Mei Reviewers list

{"title":"Reviewers list","authors":"","doi":"10.1177/1470320319831142","DOIUrl":"https://doi.org/10.1177/1470320319831142","url":null,"abstract":"Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Adaya, Ceyla Aguilar, Marie-Isabel Allen, Terri Almeida, Madison Arumugam, Vijaya Barbosa da Silva, Sandra Barwood, Martin Bernardi, Stella Borghi, Claudio Bourgi, Ali Braszko, Jan Canto, Patricia Capewell, Simon Capuccio, Franco Cardillo, Carmine Carlsson, AC Chappell, Mark Danilov, Sergei Delevatti, RS der Groot, Joris Du, Jun-Bao Ekholm, Mikael Erbas, Tomris Ferrario, Carlos Fonseca-Alaniz, MH Fuller, Peter Funder, John Gismondi, Ronaldo Goessler, Karla Gregg, Lucile Gromotowicz-Poplawska, Anna Gros, Robert Hayashi, Kaori Hering, Dagmara Hevia, Vital Ho, Jean Holtzenberg, Maria ISORDIA-SALAS, IRMA Jalil, Jorge Jin, Hongfang Kamei, Motohiro Kosar, Ali Kurlak, Lesi Li, Qifu Liu, Fang-zhou Liu, L Lu, Xifeng MacGregor, Graham Miak, Radoslaw Mohan, Irwin Moraes, Karen Morimoto, Satoshi Murakami, T Narayan, Prakash Ohashi, N Omboni, Stefano Rodriguez, R Roks, Anton Rossi, Gianpaolo Rubio Guerra, Alberto Francisco Säemann, Marcus Saigusa, T Sever, Peter Sharifi, Niura Shenoy, Vinayak Shu, Daisy Siltari, Aino Simao, S Simoes e Silva, Ana Simone, Giuseppe Simonyte, Sandrita Simonyte, Sandrita Song, Ping Stegbauer, Johannes Tain, You-Lin White, Andrew Woo, KT Xue, B Zhao, Qinchum Zhu, Mei Reviewers list","PeriodicalId":17330,"journal":{"name":"Journal of the Renin-Angiotensin-Aldosterone System","volume":"107 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83552127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0