{"title":"A case of Bowen disease on the sole associated with human papillomavirus type 33","authors":"K. Murao, K. Yamasaki, Y. Kubo","doi":"10.3812/jocd.38.57","DOIUrl":"https://doi.org/10.3812/jocd.38.57","url":null,"abstract":"77歳，女性．左足底の皮膚腫瘍に気づき，当科を受診した．左足底の土踏まず部近くに，直径5 mmの境界が比較的明瞭でわずかに周囲より隆起する，淡褐色で軽度角化する結節を認めた．病理組織では，角質は肥厚し，表皮全層性に核の大小不同，濃染など異型性を示す腫瘍細胞が増殖し，配列は乱れていた．顆粒層近くと肥厚した角層内には胞体の明るいkoilocyteを多数認めた．パラフィン包埋切片よりDNAを抽出し，ヒト乳頭腫ウイルス（human papillomavirus; HPV）の検索を行ったところ，粘膜型，ハイリスク型であるHPV33型のDNAが検出された．足底にBowen病が生じることは非常にまれであるが，これまでの報告例でしばしば粘膜型のHPVが病変部より検出されている．外陰部，手指のBowen病はHPV感染との関連が強いことはよく知られているが，足底のBowen病もHPVが発症に関与している可能性の高い病変であると考える．","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86860071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Tsunemi, Naoko Mori, Yumiko Uchikata, Tsuyoshi Kani, K. Matsui
{"title":"Investigation of the effectiveness and safety of ozenoxacin lotion (Zebiax® Lotion 2%) on superficial skin infections by a drug use-results survey","authors":"Y. Tsunemi, Naoko Mori, Yumiko Uchikata, Tsuyoshi Kani, K. Matsui","doi":"10.3812/jocd.38.906","DOIUrl":"https://doi.org/10.3812/jocd.38.906","url":null,"abstract":"","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82142448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryo Ogawa, N. Umegaki, Masayuki Urabe, S. Ishizaki, Masaru Tanaka
Eruptive syringoma is a rare type of syringoma, a benign tumor of the eccrine ducts, and is characterized by the presence of widespread hyperpigmented papules on the trunk with onset around puberty. Here, we report two cases of eruptive syringoma presenting with characteristic dermoscopic findings. Case 1 involved a 21-year-old man who had developed a widespread skin rash on his trunk around the age of 19 years. Clinical examination showed small brown papules spreading on the trunk and both axillae. The differential diagnoses included verruca plana and Darier's disease. Case 2 involved a 67-year-old man who had been aware of itchy brown papules on the trunk since he was in his twenties. Dermoscopy in cases 1 and 2 showed homogeneous light brown pigmentation with multifocal whitish areas and a delicate pigment network at the periphery, which are typical characteristics of eruptive syringoma. Histopathological examination showed numerous small ducts and islands of epithelium embedded in a fibrous stroma in the upper dermis. These findings were compatible with the diagnosis of eruptive syringoma in cases 1 and 2. On comparing the dermoscopic and histopathological findings of syringoma, the whitish area with unclear borders corresponded to the fibrous stroma in the upper dermis, and the unclear borders corresponded to the dermal lesion. Therefore, dermoscopy differentiate skin verruca
{"title":"Two cases of eruptive syringoma presenting with characteristic dermoscopic findings","authors":"Ryo Ogawa, N. Umegaki, Masayuki Urabe, S. Ishizaki, Masaru Tanaka","doi":"10.3812/jocd.38.618","DOIUrl":"https://doi.org/10.3812/jocd.38.618","url":null,"abstract":"Eruptive syringoma is a rare type of syringoma, a benign tumor of the eccrine ducts, and is characterized by the presence of widespread hyperpigmented papules on the trunk with onset around puberty. Here, we report two cases of eruptive syringoma presenting with characteristic dermoscopic findings. Case 1 involved a 21-year-old man who had developed a widespread skin rash on his trunk around the age of 19 years. Clinical examination showed small brown papules spreading on the trunk and both axillae. The differential diagnoses included verruca plana and Darier's disease. Case 2 involved a 67-year-old man who had been aware of itchy brown papules on the trunk since he was in his twenties. Dermoscopy in cases 1 and 2 showed homogeneous light brown pigmentation with multifocal whitish areas and a delicate pigment network at the periphery, which are typical characteristics of eruptive syringoma. Histopathological examination showed numerous small ducts and islands of epithelium embedded in a fibrous stroma in the upper dermis. These findings were compatible with the diagnosis of eruptive syringoma in cases 1 and 2. On comparing the dermoscopic and histopathological findings of syringoma, the whitish area with unclear borders corresponded to the fibrous stroma in the upper dermis, and the unclear borders corresponded to the dermal lesion. Therefore, dermoscopy differentiate skin verruca","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75633492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"One hundred five cases of chronic spontaneous urticaria treated with omalizumab","authors":"Tomonobu Ito, Y. Okubo, K. Harada","doi":"10.3812/jocd.38.892","DOIUrl":"https://doi.org/10.3812/jocd.38.892","url":null,"abstract":"","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90977712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delayed injection-site reactions caused by COVID-19 vaccine: COVID arm.","authors":"Y. Matsudate","doi":"10.3812/jocd.38.754","DOIUrl":"https://doi.org/10.3812/jocd.38.754","url":null,"abstract":"","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76127815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"顔面に生じた粘膜関連リンパ組織節外性辺縁帯リンパ腫（extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue）の1例","authors":"Keiko Takada, Nagisa Yoshihara, Etsuko Komiyama, Shigaku Ikeda","doi":"10.3812/JOCD.38.624","DOIUrl":"https://doi.org/10.3812/JOCD.38.624","url":null,"abstract":"","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78884527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A questionnaire survey on the current status of treatment of patients with recurrent genital herpes","authors":"D. Watanabe, Aya Osuga, Hiroaki Fukuda, Yoshinobu Kikukawa","doi":"10.3812/jocd.38.445","DOIUrl":"https://doi.org/10.3812/jocd.38.445","url":null,"abstract":"再発性性器ヘルペス（recurrent genital herpes：RGH）患者232名と，皮膚科，婦人科・産婦人科（以下，婦人科），泌尿器科の医師231名を対象に，RGHの患者ニーズおよび医師の診療実態に関するアンケート調査を行った． 回答を得た患者の男女比は6：4で，再発頻度が年1～2回の患者が8割を占めた．患者全体の6割が内服抗ウイルス薬（以下，内服薬）を単独または併用で使用していたのに対し，3割は外用抗ウイルス薬（以下，外用薬）のみで治療していると回答した．現在の治療を「満足」とした患者は，Patient Initiated Therapy（以下，PIT）で44.6%，5日間投与で31.1%，再発抑制療法で32.5%，外用薬のみで17.6%であった． 診断にウイルス抗体検査を用いると回答した医師のうち，受診時の皮疹におけるウイルスの有無を判断する目的で抗体検査を実施すると回答した医師は，婦人科および泌尿器科で半数を超えた． RGH診療で重視することは患者と医師で大きく異なり，最も差が大きかった項目は「再発をなくす」（患者38.8%：医師16.9%）であった． 本調査の結果，日本性感染症学会等の診療ガイドラインで推奨されている内服治療が治療の中心であったものの，外用薬のみでの治療が一定数行われており，ガイドラインが十分に浸透してない可能性も考えられた． 内服薬による治療は，外用薬のみの治療に比べ患者満足度が高かった．RGHにおいては再発を完全に防ぐことは困難であるが，内服療法を基本とした，患者自身が積極的に再発に対処できる治療が活用されると共に，患者の悩みや希望に寄り添った患者指導が行われるようになることが望まれる．","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78032086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alopecia areata (AA) is a commonly encountered autoimmune-mediated hair loss disease clinically characterized by well-demarcated hair loss patches and histologically by dense peribulbar lymphocytic cell infiltration leading to the destruction of hair follicles. Because of its distinctive clinical presentation, other hair loss diseases presenting clear hair loss patches can be misdiagnosed as AA. Thus, the confirmation of AA diagnosis by the combination of diagnostic approaches, including physical examination, hair pull test, trichoscopy, and skin biopsy is important. Trichotillomania (TT), scarring alopecia (represented by lichen planopilaris and chronic lupus erythematosus), tinea capitis, and triangular alopecia can manifest hair loss patches or areas hardly distinguishable from those in AA. Such findings as the absence of hair shaft pluckability or atrophic changes in the hair bulb, microscopic detection of fungi within isolated plucked hair shafts should be helpful to distinguish the aforementioned non-AA hair loss diseases from AA. Trichoscopic detection of follicular microhemorrhage, V-sign, and flame hairs are useful for the diagnosis of TT, while loss of the hair ostia is typical for scarring alopecia. Triangular alopecia is less frequently encountered and is distinguished by the presence of vellus-like hairs with in clinically hair loss patches as detected by trichoscopy. AA may present hair loss pattern resembling those of androgenetic alopecia (AGA) and female patten hair loss (FPHL). Hair miniaturization may be observed in the recovery phase of AA and in AGA
{"title":"A guide to distinguish alopecia areata from other hair loss diseases presenting similar clinical manifestations","authors":"M. Ohyama","doi":"10.3812/jocd.38.611","DOIUrl":"https://doi.org/10.3812/jocd.38.611","url":null,"abstract":"Alopecia areata (AA) is a commonly encountered autoimmune-mediated hair loss disease clinically characterized by well-demarcated hair loss patches and histologically by dense peribulbar lymphocytic cell infiltration leading to the destruction of hair follicles. Because of its distinctive clinical presentation, other hair loss diseases presenting clear hair loss patches can be misdiagnosed as AA. Thus, the confirmation of AA diagnosis by the combination of diagnostic approaches, including physical examination, hair pull test, trichoscopy, and skin biopsy is important. Trichotillomania (TT), scarring alopecia (represented by lichen planopilaris and chronic lupus erythematosus), tinea capitis, and triangular alopecia can manifest hair loss patches or areas hardly distinguishable from those in AA. Such findings as the absence of hair shaft pluckability or atrophic changes in the hair bulb, microscopic detection of fungi within isolated plucked hair shafts should be helpful to distinguish the aforementioned non-AA hair loss diseases from AA. Trichoscopic detection of follicular microhemorrhage, V-sign, and flame hairs are useful for the diagnosis of TT, while loss of the hair ostia is typical for scarring alopecia. Triangular alopecia is less frequently encountered and is distinguished by the presence of vellus-like hairs with in clinically hair loss patches as detected by trichoscopy. AA may present hair loss pattern resembling those of androgenetic alopecia (AGA) and female patten hair loss (FPHL). Hair miniaturization may be observed in the recovery phase of AA and in AGA","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83454168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and safety of fosravuconazole in patients with onychomycosis in our clinic","authors":"W. Naka","doi":"10.3812/jocd.38.62","DOIUrl":"https://doi.org/10.3812/jocd.38.62","url":null,"abstract":"目的と方法：実臨床における爪白癬患者に対するホスラブコナゾールL-リシンエタノール付加物（ネイリンⓇカプセル，以下ホスラブコナゾール）の有効性および安全性を検討する目的で，2018年8月～2020年2月に当院を受診し，爪白癬の診断の下にホスラブコナゾールを処方された患者を対象としてカルテ情報を収集した． 結果：対象は爪白癬患者360例（足爪白癬340例，手爪白癬28例，そのうち両者の重複例8例）で，男女とも70歳台が最も多かった．ホスラブコナゾール12週投与を終了し投与開始から1年以上経過した足爪白癬84例における治療成績は完全治癒59例（70.2％），転帰不明22例（26.2％），無効3例（3.6％）であった．完全治癒は治療開始後3カ月と6～12カ月に確認できた例が多く，転帰不明例の多くはドロップアウト（最終来院）時に改善傾向を示していた．360例中ホスラブコナゾール12週の投与を完結できた症例は249例（69.2％）で，治験で除外されていた高齢者や若年者，手の爪白癬または難治な爪白癬に対しても本薬の高い有効性が認められた．投薬中の臨床検査にて260例中ALT/ASTは18例（6.9%）に，γ-GTPは61例（23.5％）に異常値を認めたが，皮膚症状など他の副作用を含め重篤な例はなかった． 結論：ホスラブコナゾールは実臨床においても完全治癒率と投与継続率が高く，肝機能検査など適切な対処により重篤な副作用を回避できることから，合併症などで内服が困難な例や外用薬で早期完治が期待できる例を除き，すべての爪白癬症例において早く確実に治すための第一選択薬として用いられるべき薬剤と思われる．","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73725257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nobukazu Hayashi, Yuri Sasaki, I. Kurokawa, M. Tanioka, F. Furukawa, Y. Miyachi, Yuki Yamamoto, M. Kawashima
{"title":"Survey of dermatologists on the clinical need for oral isotretinoin in the treatment of acne conglobata and severe acne vulgaris","authors":"Nobukazu Hayashi, Yuri Sasaki, I. Kurokawa, M. Tanioka, F. Furukawa, Y. Miyachi, Yuki Yamamoto, M. Kawashima","doi":"10.3812/jocd.38.629","DOIUrl":"https://doi.org/10.3812/jocd.38.629","url":null,"abstract":"","PeriodicalId":17355,"journal":{"name":"Journal of The Japan Organization of Clinical Dermatologists","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83961908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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