{"title":"Wheat and chaff in Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) in clinics and laboratory.","authors":"Umberto Tirelli, Marianno Franzini, Salvatore Chirumbolo","doi":"10.1186/s12967-025-07397-z","DOIUrl":"10.1186/s12967-025-07397-z","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"24 1","pages":"20"},"PeriodicalIF":7.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12772095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1186/s12967-025-07292-7
Aymin Javed, Nadeem Javaid, Muhammad Shafiq, Jin-Ghoo Choi, Nabil Alrajeh
{"title":"A 3-tier information fusioned framework featuring explainable deep active optimized CRNet for accurate heart disease prediction.","authors":"Aymin Javed, Nadeem Javaid, Muhammad Shafiq, Jin-Ghoo Choi, Nabil Alrajeh","doi":"10.1186/s12967-025-07292-7","DOIUrl":"10.1186/s12967-025-07292-7","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":" ","pages":"27"},"PeriodicalIF":7.5,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1186/s12967-025-07378-2
T S Ramasubramanian, Pichet Adstamongkonkul, Christina M Scribano, Christin Johnson, Sean Caenepeel, Laura C F Hrycyniak, Lindsey C Vedder, Nicholas Dana, Christian Baltes, Victoria Browning, Yuan-I Chen, Thomas Dietz, Evan Flietner, Nicholas Kaplewski, Anna Kellner, Michael Korrer, Chao Liu, Nathan Marhefke, Payton McDonnell, Amreen Nasreen, Victoria Pope, Abhijeet Prasad, Jordyn Richardson, Sidney Schneider, Mikaela M Schultz, Chetan Sood, Aishwarya Sunil, Erika von Euw, Eric Wait, Ellen E Wargowski, Pooja Advani, Barbara Broome, Antje Bruckbauer, Andrew Godwin, Nima Kokabi, Yanyan Lou, Robert C G Martin, Mercedes Robaina, Giuseppe Toia, Joshua Routh, Andreas Friedl, Kevin Eliceiri, Michael Szulczewski, Scott Johnson, Jon Oliner, Jérôme Galon, Christian Capitini, Debabrata Mukhopadhyay, Janis Taube, David Braun, Hinco J Gierman
{"title":"A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity.","authors":"T S Ramasubramanian, Pichet Adstamongkonkul, Christina M Scribano, Christin Johnson, Sean Caenepeel, Laura C F Hrycyniak, Lindsey C Vedder, Nicholas Dana, Christian Baltes, Victoria Browning, Yuan-I Chen, Thomas Dietz, Evan Flietner, Nicholas Kaplewski, Anna Kellner, Michael Korrer, Chao Liu, Nathan Marhefke, Payton McDonnell, Amreen Nasreen, Victoria Pope, Abhijeet Prasad, Jordyn Richardson, Sidney Schneider, Mikaela M Schultz, Chetan Sood, Aishwarya Sunil, Erika von Euw, Eric Wait, Ellen E Wargowski, Pooja Advani, Barbara Broome, Antje Bruckbauer, Andrew Godwin, Nima Kokabi, Yanyan Lou, Robert C G Martin, Mercedes Robaina, Giuseppe Toia, Joshua Routh, Andreas Friedl, Kevin Eliceiri, Michael Szulczewski, Scott Johnson, Jon Oliner, Jérôme Galon, Christian Capitini, Debabrata Mukhopadhyay, Janis Taube, David Braun, Hinco J Gierman","doi":"10.1186/s12967-025-07378-2","DOIUrl":"10.1186/s12967-025-07378-2","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"24 1","pages":"18"},"PeriodicalIF":7.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12763878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1186/s12967-025-07486-z
David C Klonoff, Agatha F Scheideman, Mandy M Shao, Cindy N Ho, Alessandra T Ayers, Johan Jendle, Henry G Wykowski, Lutz Heinemann
{"title":"The need for clear medical data ownership laws.","authors":"David C Klonoff, Agatha F Scheideman, Mandy M Shao, Cindy N Ho, Alessandra T Ayers, Johan Jendle, Henry G Wykowski, Lutz Heinemann","doi":"10.1186/s12967-025-07486-z","DOIUrl":"10.1186/s12967-025-07486-z","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"24 1","pages":"5"},"PeriodicalIF":7.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12763853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1186/s12967-025-07650-5
Hao Wei, Lisha Xiang, Yu Zhou, Yanxi Huang, Lei Liu, Dan Cao
{"title":"Targeting NKG2D/NKG2DL axis in cancer immunotherapy: mechanisms and therapeutic applications.","authors":"Hao Wei, Lisha Xiang, Yu Zhou, Yanxi Huang, Lei Liu, Dan Cao","doi":"10.1186/s12967-025-07650-5","DOIUrl":"https://doi.org/10.1186/s12967-025-07650-5","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Glioblastoma multiforme (GBM), the most aggressive primary brain tumor, is associated with extremely poor patient prognosis. Temozolomide (TMZ) resistance remains a major cause of treatment failure. Protein arginine methyltransferase 6 (PRMT6) plays critical roles in tumorigenesis, but its function and regulatory mechanisms in GBM TMZ resistance have not been elucidated. While the hypoxic microenvironment is a hallmark feature of GBM, its epigenetic regulatory mechanisms in drug resistance remain unclear.
Methods: We analyzed PRMT6 expression and prognostic value in GBM using public databases (TCGA, CGGA). TMZ resistance was assessed through in vitro assays (CCK-8, flow cytometry, colony formation) and in vivo xenograft models. Molecular mechanisms of the HIF-1α/PRMT6/G3BP1 axis were investigated via RNA sequencing, ChIP-qPCR, dual-luciferase reporter assays, and co-immunoprecipitation.
Results: PRMT6 was highly expressed in GBM and correlated with poor prognosis. Hypoxia transcriptionally activated PRMT6 through HIF-1α. Elevated PRMT6 expression promoted TMZ resistance, while its knockdown enhanced drug sensitivity. Mechanistically, PRMT6 interacted with transcription factor GABPA to upregulate stress granule core protein G3BP1, subsequently suppressing pro-apoptotic BCL2L13 and conferring chemoresistance. In vivo studies confirmed that both PRMT6 and G3BP1 significantly influenced TMZ resistance.
Conclusion: This study provides evidence that hypoxia mediates TMZ resistance in GBM through the HIF-1α/PRMT6/G3BP1 axis, identifying PRMT6 and G3BP1 as promising therapeutic targets to overcome chemoresistance.
{"title":"Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1.","authors":"Shuyang Chen, Peng Yu, Yongqing Sun, Yuting Yan, Boxiang Zhang, Guangyu Li","doi":"10.1186/s12967-025-07618-5","DOIUrl":"https://doi.org/10.1186/s12967-025-07618-5","url":null,"abstract":"<p><strong>Background: </strong>Glioblastoma multiforme (GBM), the most aggressive primary brain tumor, is associated with extremely poor patient prognosis. Temozolomide (TMZ) resistance remains a major cause of treatment failure. Protein arginine methyltransferase 6 (PRMT6) plays critical roles in tumorigenesis, but its function and regulatory mechanisms in GBM TMZ resistance have not been elucidated. While the hypoxic microenvironment is a hallmark feature of GBM, its epigenetic regulatory mechanisms in drug resistance remain unclear.</p><p><strong>Methods: </strong>We analyzed PRMT6 expression and prognostic value in GBM using public databases (TCGA, CGGA). TMZ resistance was assessed through in vitro assays (CCK-8, flow cytometry, colony formation) and in vivo xenograft models. Molecular mechanisms of the HIF-1α/PRMT6/G3BP1 axis were investigated via RNA sequencing, ChIP-qPCR, dual-luciferase reporter assays, and co-immunoprecipitation.</p><p><strong>Results: </strong>PRMT6 was highly expressed in GBM and correlated with poor prognosis. Hypoxia transcriptionally activated PRMT6 through HIF-1α. Elevated PRMT6 expression promoted TMZ resistance, while its knockdown enhanced drug sensitivity. Mechanistically, PRMT6 interacted with transcription factor GABPA to upregulate stress granule core protein G3BP1, subsequently suppressing pro-apoptotic BCL2L13 and conferring chemoresistance. In vivo studies confirmed that both PRMT6 and G3BP1 significantly influenced TMZ resistance.</p><p><strong>Conclusion: </strong>This study provides evidence that hypoxia mediates TMZ resistance in GBM through the HIF-1α/PRMT6/G3BP1 axis, identifying PRMT6 and G3BP1 as promising therapeutic targets to overcome chemoresistance.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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