首页 > 最新文献

Journal of the Medical Association of Thailand = Chotmaihet thangphaet最新文献

英文 中文
Postoperative Thrombocytopenia and Coagulopathy in Cardiac Surgery with Cardiopulmonary Bypass: Incidence and Outcomes after Non-Red Cell Blood Product Transfusion 心脏手术合并体外循环术后血小板减少和凝血功能障碍:非红细胞血液制品输血后的发病率和结果
Q4 Medicine Pub Date : 2023-07-14 DOI: 10.35755/jmedassocthai.2023.07.13862
Background: Cardiopulmonary bypass (CPB) activates inflammatory and fibrinolytic pathways, potentially disrupting hemostasis. Transfusion of non-red cell blood product is a conventional method of restoring hemostasis and treating coagulopathy and thrombocytopenia, the two common adverse outcomes of CPB.Objective: To determine the incidence and outcomes of postoperative thrombocytopenia and coagulopathy in adult Thai cardiac surgery patients with CPB receiving non-red cell blood product transfusions.Materials and Methods: The present study included patients aged 18 years and older that underwent cardiac surgery with CPB at Siriraj Hospital between January 2017 and June 2018. Enrolled patients were divided into four groups, no non-red cell blood products in Group 1, platelets (PLT) only in Group 2, fresh frozen plasma (FFP) and/or cryoprecipitate (cryo) in Group 3, and PLT, FFP and/or cryo in Group 4. Patients, clinical status and histories, intraoperative outcomes, and perioperative outcomes were collected and assessed for all groups. Postoperative thrombocytopenia was defined by PLT counts less than 100,000 cells/mm³. Coagulopathy was defined by prothrombin time (PT) or activated partial thromboplastin time (aPTT) greater than 1.5 of its institutional reference values. Non-red cell blood product transfusions for cardiac patients were determined by their attending physician.Results: Of the 360 patients included, 61.7% were male, with a mean (±SD) age of 65.3±11.7 years, and BMI of 24.1±4.0 kg/m². Most patients were classified as ASA-PS class 3 (71.9%), had elective surgeries (96.4%), history of antiplatelet use (65.8%), and coronary artery bypass graft (CABG) surgical procedure (56.9%). Postoperative thrombocytopenia was significantly more prevalent in Group 1 at 11.6%, followed by Group 3 at 9.5%, Group 4 at 3.7%, and Group 2 at 0% (p=0.010). Post-operative coagulopathy was more prevalent in Group 3 at 4.8%, followed by Group 2 at 4.1%, Group 1 at 3.9%, and Group 4 at 0.7%. Group 4 had a significantly greater incidence of anticoagulant use at 17.8% (p=0.007) and significantly longer CPB durations compared to the other groups at 146.6±74.7 minutes (p<0.01).Conclusion: The researchers’ study confirmed that preoperative antithrombotic use prior to cardiac surgical procedures and longer CPB duration influences physicians’ decision to transfuse. The present study recommended prohibiting prophylactic administration of FFP and PLT as well as implementing restrictive non-red cell blood product transfusion strategies.Keywords: Thrombocytopenia; Coagulopathy; Non-red Cell Blood Product Transfusion; Cardiopulmonary Bypass; Cardiac Surgery
背景:体外循环(CPB)激活炎症和纤溶途径,潜在地破坏止血。输血非红细胞血液制品是恢复止血和治疗凝血功能障碍和血小板减少症的常规方法,这是CPB的两种常见不良后果。目的:了解泰国成年心脏手术CPB患者接受非红细胞血制品输血后血小板减少和凝血功能障碍的发生率和结局。材料与方法:本研究纳入了2017年1月至2018年6月期间在Siriraj医院接受CPB心脏手术的18岁及以上患者。入组患者分为四组,第一组无非红细胞血制品,第二组仅含血小板(PLT),第三组为新鲜冷冻血浆(FFP)和/或冷冻沉淀(cryo),第四组为PLT、FFP和/或冷冻。收集并评估所有组的患者、临床状况和病史、术中结局和围术期结局。术后血小板减少的定义是血小板计数小于100,000细胞/mm³。凝血功能障碍的定义是凝血酶原时间(PT)或活化部分凝血活酶时间(aPTT)大于其机构参考值的1.5倍。心脏病患者的非红细胞血液制品输注由其主治医师决定。结果:360例患者中,男性占61.7%,平均(±SD)年龄为65.3±11.7岁,BMI为24.1±4.0 kg/m²。大多数患者被分类为ASA-PS 3级(71.9%),有择期手术(96.4%),有抗血小板使用史(65.8%),有冠状动脉旁路移植术(CABG)手术(56.9%)。术后血小板减少发生率在第1组为11.6%,第3组为9.5%,第4组为3.7%,第2组为0% (p=0.010)。术后凝血功能障碍在第3组更为普遍,为4.8%,其次是第2组4.1%,第1组3.9%,第4组0.7%。第4组抗凝剂使用率为17.8% (p=0.007), CPB持续时间为146.6±74.7 min,明显高于其他组(p<0.01)。结论:研究人员的研究证实,心脏外科手术前的术前抗血栓治疗和较长的CPB持续时间影响医生是否输血的决定。本研究建议禁止预防性使用FFP和PLT,并实施限制性非红细胞制品输血策略。关键词:血小板减少症;凝血障碍;非红细胞输血;心肺旁路;心脏手术
{"title":"Postoperative Thrombocytopenia and Coagulopathy in Cardiac Surgery with Cardiopulmonary Bypass: Incidence and Outcomes after Non-Red Cell Blood Product Transfusion","authors":"","doi":"10.35755/jmedassocthai.2023.07.13862","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.07.13862","url":null,"abstract":"Background: Cardiopulmonary bypass (CPB) activates inflammatory and fibrinolytic pathways, potentially disrupting hemostasis. Transfusion of non-red cell blood product is a conventional method of restoring hemostasis and treating coagulopathy and thrombocytopenia, the two common adverse outcomes of CPB.\u0000\u0000Objective: To determine the incidence and outcomes of postoperative thrombocytopenia and coagulopathy in adult Thai cardiac surgery patients with CPB receiving non-red cell blood product transfusions.\u0000\u0000Materials and Methods: The present study included patients aged 18 years and older that underwent cardiac surgery with CPB at Siriraj Hospital between January 2017 and June 2018. Enrolled patients were divided into four groups, no non-red cell blood products in Group 1, platelets (PLT) only in Group 2, fresh frozen plasma (FFP) and/or cryoprecipitate (cryo) in Group 3, and PLT, FFP and/or cryo in Group 4. Patients, clinical status and histories, intraoperative outcomes, and perioperative outcomes were collected and assessed for all groups. Postoperative thrombocytopenia was defined by PLT counts less than 100,000 cells/mm³. Coagulopathy was defined by prothrombin time (PT) or activated partial thromboplastin time (aPTT) greater than 1.5 of its institutional reference values. Non-red cell blood product transfusions for cardiac patients were determined by their attending physician.\u0000\u0000Results: Of the 360 patients included, 61.7% were male, with a mean (±SD) age of 65.3±11.7 years, and BMI of 24.1±4.0 kg/m². Most patients were classified as ASA-PS class 3 (71.9%), had elective surgeries (96.4%), history of antiplatelet use (65.8%), and coronary artery bypass graft (CABG) surgical procedure (56.9%). Postoperative thrombocytopenia was significantly more prevalent in Group 1 at 11.6%, followed by Group 3 at 9.5%, Group 4 at 3.7%, and Group 2 at 0% (p=0.010). Post-operative coagulopathy was more prevalent in Group 3 at 4.8%, followed by Group 2 at 4.1%, Group 1 at 3.9%, and Group 4 at 0.7%. Group 4 had a significantly greater incidence of anticoagulant use at 17.8% (p=0.007) and significantly longer CPB durations compared to the other groups at 146.6±74.7 minutes (p<0.01).\u0000\u0000Conclusion: The researchers’ study confirmed that preoperative antithrombotic use prior to cardiac surgical procedures and longer CPB duration influences physicians’ decision to transfuse. The present study recommended prohibiting prophylactic administration of FFP and PLT as well as implementing restrictive non-red cell blood product transfusion strategies.\u0000\u0000Keywords: Thrombocytopenia; Coagulopathy; Non-red Cell Blood Product Transfusion; Cardiopulmonary Bypass; Cardiac Surgery","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74860950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasoalveolar Rhabdomyosarcoma Presenting as Traumatic Nasal Injury: A Rare Case Report Mimicking Organized Hematoma 鼻肺泡横纹肌肉瘤表现为外伤性鼻损伤:一例罕见的模拟组织血肿的病例报告
Q4 Medicine Pub Date : 2023-07-14 DOI: 10.35755/jmedassocthai.2023.07.13866
The nasoalveolar region is an uncommon area of all rhabdomyosarcoma (RMS) cases. RMS has a bimodal distribution in children, occurring in those aged two to four years and 12 to 16 years. The authors presented an unusual case of alveolar RMS that presented at a young age, in an uncommon region, with an atypical presentation, and imaging findings mimicking organized hematoma and complicated nasoalveolar cyst. Confounding as a result of the presence of trauma can delay diagnosis and treatment.Keywords: Nasoalveolar; Rhabdomyosarcoma; Hematoma
鼻肺泡区是所有横纹肌肉瘤(RMS)病例中不常见的区域。RMS在儿童中呈双峰分布,发生在2至4岁和12至16岁的儿童中。作者提出了一个不寻常的肺泡RMS病例,出现在年轻的时候,在一个不寻常的区域,具有不典型的表现,和成像结果模拟有组织的血肿和复杂的鼻肺泡囊肿。由于创伤的存在而造成的混淆会延误诊断和治疗。关键词:Nasoalveolar;横纹肌肉瘤;血肿
{"title":"Nasoalveolar Rhabdomyosarcoma Presenting as Traumatic Nasal Injury: A Rare Case Report Mimicking Organized Hematoma","authors":"","doi":"10.35755/jmedassocthai.2023.07.13866","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.07.13866","url":null,"abstract":"The nasoalveolar region is an uncommon area of all rhabdomyosarcoma (RMS) cases. RMS has a bimodal distribution in children, occurring in those aged two to four years and 12 to 16 years. The authors presented an unusual case of alveolar RMS that presented at a young age, in an uncommon region, with an atypical presentation, and imaging findings mimicking organized hematoma and complicated nasoalveolar cyst. Confounding as a result of the presence of trauma can delay diagnosis and treatment.\u0000\u0000Keywords: Nasoalveolar; Rhabdomyosarcoma; Hematoma","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91196858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a Thai Herbal Remedy in Patients with Mild Chronic Plaque Psoriasis: An Observer-Blinded Randomized, Standard Treatment-Controlled Trial 一种泰国草药治疗轻度慢性斑块型银屑病的疗效:一项观察者盲法随机标准治疗对照试验
Q4 Medicine Pub Date : 2023-07-14 DOI: 10.35755/jmedassocthai.2023.07.13864
Background: Psoriasis is a chronic non-infectious inflammatory skin disease caused by genetic and environmental predispositions. There is a Thai herbal remedy for psoriasis recorded in Wat Pho’s marble inscriptions, consisting of Dictyophora indusiate Fisch, Psilocybe cubensis (Earle) Sing, and sesame oil.Objective: To compare the efficacy and safety of a Thai herbal remedy as an alternative treatment to the standard treatment of 0.1% triamcinolone lotion in patients with mild chronic plaque psoriasis.Materials and Methods: A randomized, split-body controlled design was conducted in 30 mild chronic plaque-type psoriasis patients with symmetrically distributed psoriasis rashes. Each patient was randomized to apply a Thai herbal remedy on a rash on one side of the body and 0.1% triamcinolone lotion on the other side, using the same dosage of twice daily for eight weeks. Efficacy was assessed at week 1, 2, 4, and 8 by the Targeted Area Score (TAS). The Self-Assessment Score (SAS) at week 8 was compared to the baseline. Safety was assessed through the interviews at each visit. Product satisfaction was evaluated by the visual analog scale (VAS).Results: The TAS and SAS for erythema, desquamation, and induration decreased in both treatment groups, with no significant difference. However, product satisfaction in color (p=0.012), odor (p=0.013), and absorption (p=0.003) were significantly higher in the 0.1% triamcinolone lotion group.Conclusion: The present study showed that the Thai herbal remedy was safe and efficacious in treating chronic plaque-type psoriasis, therefore, can be used as an alternative treatment.Keywords: Thai herbal remedy; Psoriasis; Dictyophora indusiate Fisch; Psilocybe cubensis (Earle) Sing; Sesame oil
背景:银屑病是一种由遗传和环境易感性引起的慢性非感染性炎症性皮肤病。在卧佛寺的大理石铭文中记载了一种治疗牛皮癣的泰国草药,由工业鱼、裸盖菇(Earle) Sing和香油组成。目的:比较泰国草药替代0.1%曲安奈德洗剂治疗轻度慢性斑块型银屑病的疗效和安全性。材料与方法:对30例均匀分布银屑病皮疹的轻度慢性斑块型银屑病患者进行随机、分体对照设计。每位患者被随机分配在身体一侧的皮疹上涂抹泰国草药,另一侧涂抹0.1%曲安奈德洗剂,使用相同剂量,每天两次,持续8周。在第1、2、4和8周通过目标区域评分(TAS)评估疗效。第8周的自评评分(SAS)与基线比较。安全性通过每次访问时的访谈进行评估。采用视觉模拟量表(VAS)评价产品满意度。结果:两组红斑、脱屑、硬结的TAS和SAS均降低,差异无统计学意义。然而,0.1%曲安奈德洗剂组在颜色(p=0.012)、气味(p=0.013)和吸收率(p=0.003)方面的产品满意度显著高于0.1%曲安奈德洗剂组。结论:本研究表明泰方中药治疗慢性斑块型银屑病安全有效,可作为一种替代治疗方法。关键词:泰药;牛皮癣;工业鱼;裸盖菇;芝麻油
{"title":"Efficacy of a Thai Herbal Remedy in Patients with Mild Chronic Plaque Psoriasis: An Observer-Blinded Randomized, Standard Treatment-Controlled Trial","authors":"","doi":"10.35755/jmedassocthai.2023.07.13864","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.07.13864","url":null,"abstract":"Background: Psoriasis is a chronic non-infectious inflammatory skin disease caused by genetic and environmental predispositions. There is a Thai herbal remedy for psoriasis recorded in Wat Pho’s marble inscriptions, consisting of Dictyophora indusiate Fisch, Psilocybe cubensis (Earle) Sing, and sesame oil.\u0000\u0000Objective: To compare the efficacy and safety of a Thai herbal remedy as an alternative treatment to the standard treatment of 0.1% triamcinolone lotion in patients with mild chronic plaque psoriasis.\u0000\u0000Materials and Methods: A randomized, split-body controlled design was conducted in 30 mild chronic plaque-type psoriasis patients with symmetrically distributed psoriasis rashes. Each patient was randomized to apply a Thai herbal remedy on a rash on one side of the body and 0.1% triamcinolone lotion on the other side, using the same dosage of twice daily for eight weeks. Efficacy was assessed at week 1, 2, 4, and 8 by the Targeted Area Score (TAS). The Self-Assessment Score (SAS) at week 8 was compared to the baseline. Safety was assessed through the interviews at each visit. Product satisfaction was evaluated by the visual analog scale (VAS).\u0000\u0000Results: The TAS and SAS for erythema, desquamation, and induration decreased in both treatment groups, with no significant difference. However, product satisfaction in color (p=0.012), odor (p=0.013), and absorption (p=0.003) were significantly higher in the 0.1% triamcinolone lotion group.\u0000\u0000Conclusion: The present study showed that the Thai herbal remedy was safe and efficacious in treating chronic plaque-type psoriasis, therefore, can be used as an alternative treatment.\u0000\u0000Keywords: Thai herbal remedy; Psoriasis; Dictyophora indusiate Fisch; Psilocybe cubensis (Earle) Sing; Sesame oil","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80506101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Accuracy of Thyroid Cancer Using the American Thyroid Association Guidelines and American College of Radiology-Thyroid Imaging Reporting and Data System 使用美国甲状腺协会指南和美国放射学会甲状腺影像报告和数据系统诊断甲状腺癌的准确性
Q4 Medicine Pub Date : 2023-07-14 DOI: 10.35755/jmedassocthai.2023.07.13780
Objective: To compare the American Thyroid Association (ATA) classification system of 2015 with the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) of 2017 to determine the superior system to predict cancer risk in thyroid nodules.Materials and Methods: The present study was a retrospective study that included patients with thyroid nodule(s) referred to the department of radiology for fine-needle aspiration (FNA) between February 2019 and March 2021. The authors assessed the ability of either system to predict malignancy based on FNA cytology results. Sensitivity, specificity, negative predictive values (NPV), and positive predictive values (PPV) were calculated.Results: One hundred sixty-five nodules were reviewed based on the ATA guideline of 2015 and ACR-TI-RADS of 2017. The sensitivity, specificity, PPV, and NPV of the ATA guidelines were 95.45%, 65.04%, 29.58%, and 98.94%, respectively, while that of the ACR-TI-RADS were 95.45%, 62.24%, 28%, and 98.89%, respectively.Conclusion: The ATA guidelines of 2015 and the ACR-TI-RADS of 2017 have comparable sensitivity and NPV for thyroid carcinoma diagnosis with moderate specificity for both systems. These results confirm a high probability of both systems rejecting malignancy.Keywords: Thyroid; FNA; ATA guideline; ACR-TI-RADs
目的:比较2015年美国甲状腺协会(ATA)分类系统与2017年美国放射学会(ACR)甲状腺影像学报告与数据系统(TI-RADS),以确定预测甲状腺结节癌风险的更优系统。材料和方法:本研究是一项回顾性研究,纳入了2019年2月至2021年3月期间在放射科接受细针穿刺(FNA)治疗的甲状腺结节患者。作者根据FNA细胞学结果评估了两种系统预测恶性肿瘤的能力。计算敏感性、特异性、阴性预测值(NPV)和阳性预测值(PPV)。结果:根据2015年的ATA指南和2017年的ACR-TI-RADS对165个结节进行了回顾。ATA指南的敏感性、特异性、PPV和NPV分别为95.45%、65.04%、29.58%和98.94%,而ACR-TI-RADS的敏感性、特异性、PPV和NPV分别为95.45%、62.24%、28%和98.89%。结论:2015年的ATA指南与2017年的ACR-TI-RADS诊断甲状腺癌的敏感性和NPV相当,两种系统的特异性均中等。这些结果证实了两个系统排斥恶性肿瘤的高概率。关键词:甲状腺;FNA);ATA指南;ACR-TI-RADs
{"title":"Diagnostic Accuracy of Thyroid Cancer Using the American Thyroid Association Guidelines and American College of Radiology-Thyroid Imaging Reporting and Data System","authors":"","doi":"10.35755/jmedassocthai.2023.07.13780","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.07.13780","url":null,"abstract":"Objective: To compare the American Thyroid Association (ATA) classification system of 2015 with the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) of 2017 to determine the superior system to predict cancer risk in thyroid nodules.\u0000\u0000Materials and Methods: The present study was a retrospective study that included patients with thyroid nodule(s) referred to the department of radiology for fine-needle aspiration (FNA) between February 2019 and March 2021. The authors assessed the ability of either system to predict malignancy based on FNA cytology results. Sensitivity, specificity, negative predictive values (NPV), and positive predictive values (PPV) were calculated.\u0000\u0000Results: One hundred sixty-five nodules were reviewed based on the ATA guideline of 2015 and ACR-TI-RADS of 2017. The sensitivity, specificity, PPV, and NPV of the ATA guidelines were 95.45%, 65.04%, 29.58%, and 98.94%, respectively, while that of the ACR-TI-RADS were 95.45%, 62.24%, 28%, and 98.89%, respectively.\u0000\u0000Conclusion: The ATA guidelines of 2015 and the ACR-TI-RADS of 2017 have comparable sensitivity and NPV for thyroid carcinoma diagnosis with moderate specificity for both systems. These results confirm a high probability of both systems rejecting malignancy.\u0000\u0000Keywords: Thyroid; FNA; ATA guideline; ACR-TI-RADs","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77195695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Factors and Impact of Secondary Pulmonary Infection on Mortality in Patients with Hypoxemic COVID-19 Pneumonia: A Retrospective Cohort Study 低氧血症COVID-19肺炎患者继发肺部感染对死亡率的预测因素及影响:一项回顾性队列研究
Q4 Medicine Pub Date : 2023-07-14 DOI: 10.35755/jmedassocthai.2023.07.13765
Background: Secondary pulmonary infection (SPI) is a severe complication in patients with COVID-19.Objective: To investigate the risk factors, mortality rates, and complications associated with SPI in hypoxemic COVID-19 pneumonia patients.Materials and Methods: A retrospective cohort study was conducted at Saraburi Hospital, analyzing medical records of 512 hospitalized COVID-19 patients. The Fine-Gray model identified risk factors for SPI.Results: SPI was diagnosed in 25.4% of hypoxemic COVID-19 pneumonia patients. SPI patients (mean age of 65.9±15.1 years) had higher inflammation biomarkers, increased in-hospital mortality (IHM), and more complications than non-SPI patients. The primary pathogens causing IHM were gram-negative bacteria in 59.23%. Risk factors for SPI included age of 65 years or older (sHR 1.52; 95% CI 1.03 to 2.25; p=0.032), obesity (sHR 1.52; 95% CI 1.04 to 2.23; p=0.028), invasive mechanical ventilation (sHR 2.87; 95% CI 1.64 to 5.02; p<0.001), lactate dehydrogenase (LDH) level of 520 U/L or more (sHR 2.37; 95% CI 1.69 to 3.33; p=0.027), and catheter-related bloodstream infection (sHR 2.74; 95% CI 1.71 to 4.40; p<0.001). SPI patients had an IHM rate of 74.62%. Multivariable analysis showed higher IHM in SPI patients (aOR 5.29; 95% CI 2.70 to 10.36) compared to non-SPI patients.Conclusion: SPI is a common and harmful complication in hypoxemic COVID-19 pneumonia. Older age, obesity, invasive mechanical ventilation, elevated LDH levels, and catheter-related bloodstream infection are significant risk factors for SPI. Early detection and prevention strategies are crucial to mitigate the short-term consequences of SPI in COVID-19 patients.Keywords: COVID-19; Secondary pulmonary infection; Mortality; Risk factors
背景:继发性肺部感染(SPI)是COVID-19患者的严重并发症。目的:探讨低氧血症COVID-19肺炎患者SPI相关危险因素、死亡率及并发症。材料与方法:在萨拉布里医院进行回顾性队列研究,分析512例住院COVID-19患者的医疗记录。Fine-Gray模型确定了SPI的危险因素。结果:新冠肺炎低氧血症患者SPI阳性率为25.4%。SPI患者(平均年龄65.9±15.1岁)比非SPI患者有更高的炎症生物标志物、更高的住院死亡率(IHM)和更多的并发症。引起IHM的主要病原菌为革兰氏阴性菌,占59.23%。SPI的危险因素包括65岁及以上(sHR 1.52;95% CI 1.03 ~ 2.25;p=0.032),肥胖(sHR 1.52;95% CI 1.04 ~ 2.23;p=0.028),有创机械通气(sHR 2.87;95% CI 1.64 ~ 5.02;p<0.001),乳酸脱氢酶(LDH)水平520 U/L及以上(sHR 2.37;95% CI 1.69 ~ 3.33;p=0.027),导管相关血流感染(sHR 2.74;95% CI 1.71 - 4.40;p < 0.001)。SPI患者的IHM率为74.62%。多变量分析显示SPI患者IHM较高(aOR 5.29;95% CI 2.70 - 10.36)与非spi患者相比。结论:SPI是COVID-19低氧性肺炎常见且有害的并发症。老年、肥胖、有创机械通气、LDH水平升高和导管相关血流感染是SPI的重要危险因素。早期发现和预防策略对于减轻COVID-19患者SPI的短期后果至关重要。关键词:COVID-19;继发性肺部感染;死亡率;风险因素
{"title":"Predictive Factors and Impact of Secondary Pulmonary Infection on Mortality in Patients with Hypoxemic COVID-19 Pneumonia: A Retrospective Cohort Study","authors":"","doi":"10.35755/jmedassocthai.2023.07.13765","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.07.13765","url":null,"abstract":"Background: Secondary pulmonary infection (SPI) is a severe complication in patients with COVID-19.\u0000\u0000Objective: To investigate the risk factors, mortality rates, and complications associated with SPI in hypoxemic COVID-19 pneumonia patients.\u0000\u0000Materials and Methods: A retrospective cohort study was conducted at Saraburi Hospital, analyzing medical records of 512 hospitalized COVID-19 patients. The Fine-Gray model identified risk factors for SPI.\u0000\u0000Results: SPI was diagnosed in 25.4% of hypoxemic COVID-19 pneumonia patients. SPI patients (mean age of 65.9±15.1 years) had higher inflammation biomarkers, increased in-hospital mortality (IHM), and more complications than non-SPI patients. The primary pathogens causing IHM were gram-negative bacteria in 59.23%. Risk factors for SPI included age of 65 years or older (sHR 1.52; 95% CI 1.03 to 2.25; p=0.032), obesity (sHR 1.52; 95% CI 1.04 to 2.23; p=0.028), invasive mechanical ventilation (sHR 2.87; 95% CI 1.64 to 5.02; p<0.001), lactate dehydrogenase (LDH) level of 520 U/L or more (sHR 2.37; 95% CI 1.69 to 3.33; p=0.027), and catheter-related bloodstream infection (sHR 2.74; 95% CI 1.71 to 4.40; p<0.001). SPI patients had an IHM rate of 74.62%. Multivariable analysis showed higher IHM in SPI patients (aOR 5.29; 95% CI 2.70 to 10.36) compared to non-SPI patients.\u0000\u0000Conclusion: SPI is a common and harmful complication in hypoxemic COVID-19 pneumonia. Older age, obesity, invasive mechanical ventilation, elevated LDH levels, and catheter-related bloodstream infection are significant risk factors for SPI. Early detection and prevention strategies are crucial to mitigate the short-term consequences of SPI in COVID-19 patients.\u0000\u0000Keywords: COVID-19; Secondary pulmonary infection; Mortality; Risk factors","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73041356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Snoring in Pregnancy and Its Maternal-Fetal Outcomes at Vajira Hospital Vajira医院妊娠期打鼾的患病率及其母胎结局
Q4 Medicine Pub Date : 2023-07-14 DOI: 10.35755/jmedassocthai.2023.07.13869
Background: Snoring is an important symptom that is associated with obstructive sleep apnea and increases the risk of adverse pregnancy outcomes. In Thailand, the prevalence of snoring during pregnancy is uncertain. Determining the prevalence and characteristics may reduce the prevalence of snoring and improve pregnancy outcomes.Objective: The primary outcome was to determine the prevalence of snoring in Thai pregnant women in the third trimester, including pregnancy and chronic onset. The secondary outcome was to investigate the associations between pregnancy outcome and habitual snorer or those identified as high risk by the Thai Berlin Questionnaire.Materials and Methods: Three hundred eighty-two singleton pregnant women aged at least 18 years and at least 33 weeks of gestational age were recruited from the antenatal care clinic at Vajira Hospital, Navamindradhiraj University, between November 2021 and September 2022 and filled out the Thai Berlin Questionnaire. The 382 pregnant women were identified the presence of snoring or high risk of OSA in the previous month. Medical records, including demographic information and pregnancy outcomes, were collected, and analyzed.Results: The prevalence of snoring was 31.4% in the third trimester of pregnancy of which 27% were pregnancy onset snoring and 4.4% were chronic onset snoring. Habitual snoring was significantly different from non-snoring in regard to the requirement for positive-pressure ventilation in newborns (aOR 6.67, 95% CI 1.2 to 35.54). The high risk group had significantly more pregnancy induced hypertension than the low risk group (aOR 5.96, 95% CI 2.15 to 16.5), gestational hypertension (aOR 13.6, 95% CI 2.1 to 86.8), preeclampsia (aOR 4.07, 95% CI 1.09 to 15.2), severe preeclampsia (aOR 4.9, 95% CI 1.15 to 20.93), preterm birth (aOR 6.21, 95% CI 1.58 to 24.42), and low birth weight of newborn (aOR 6.09, 95% CI 2.5 to 14.87).Conclusion: The prevalence of snoring among Thai pregnant women was comparable to previous Western studies. Screening pregnant women at risk of the symptom may provide an early chance to lower the prevalence of snoring and adverse pregnancy outcomes.Keywords: Snoring; Snoring in pregnancy; Pregnancy outcomes
背景:打鼾是与阻塞性睡眠呼吸暂停有关的重要症状,并增加不良妊娠结局的风险。在泰国,怀孕期间打鼾的流行程度尚不确定。确定打鼾的患病率和特征可以减少打鼾的患病率,改善妊娠结局。目的:主要结局是确定泰国孕妇在妊娠晚期(包括妊娠和慢性发作)打鼾的患病率。次要结果是调查妊娠结局与习惯性打鼾者或泰国柏林问卷确定的高风险者之间的关系。材料与方法:在2021年11月至2022年9月期间,从Navamindradhiraj大学Vajira医院的产前保健诊所招募了382名年龄至少为18岁,孕龄至少为33周的单胎孕妇,并填写了泰国柏林问卷。382名孕妇在前一个月被确定有打鼾或阻塞性睡眠呼吸暂停的高风险。收集并分析了包括人口统计信息和妊娠结局在内的医疗记录。结果:妊娠晚期打鼾发生率为31.4%,其中妊娠性打鼾占27%,慢性打鼾占4.4%。在新生儿正压通气需求方面,习惯性打鼾组与非打鼾组差异有统计学意义(aOR为6.67,95% CI为1.2 ~ 35.54)。高危组妊高征发生率明显高于低危组(aOR 5.96, 95% CI 2.15 ~ 16.5)、妊娠期高血压发生率(aOR 13.6, 95% CI 2.1 ~ 86.8)、先兆子痫发生率(aOR 4.07, 95% CI 1.09 ~ 15.2)、重度先兆子痫发生率(aOR 4.07, 95% CI 1.15 ~ 20.93)、早产发生率(aOR 6.21, 95% CI 1.58 ~ 24.42)、新生儿低出生体重发生率(aOR 6.09, 95% CI 2.5 ~ 14.87)。结论:泰国孕妇打鼾的患病率与之前的西方研究相当。筛查有症状风险的孕妇可能提供早期机会,降低打鼾的患病率和不良妊娠结局。关键词:打鼾;怀孕时打鼾;妊娠结局
{"title":"Prevalence of Snoring in Pregnancy and Its Maternal-Fetal Outcomes at Vajira Hospital","authors":"","doi":"10.35755/jmedassocthai.2023.07.13869","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.07.13869","url":null,"abstract":"Background: Snoring is an important symptom that is associated with obstructive sleep apnea and increases the risk of adverse pregnancy outcomes. In Thailand, the prevalence of snoring during pregnancy is uncertain. Determining the prevalence and characteristics may reduce the prevalence of snoring and improve pregnancy outcomes.\u0000\u0000Objective: The primary outcome was to determine the prevalence of snoring in Thai pregnant women in the third trimester, including pregnancy and chronic onset. The secondary outcome was to investigate the associations between pregnancy outcome and habitual snorer or those identified as high risk by the Thai Berlin Questionnaire.\u0000\u0000Materials and Methods: Three hundred eighty-two singleton pregnant women aged at least 18 years and at least 33 weeks of gestational age were recruited from the antenatal care clinic at Vajira Hospital, Navamindradhiraj University, between November 2021 and September 2022 and filled out the Thai Berlin Questionnaire. The 382 pregnant women were identified the presence of snoring or high risk of OSA in the previous month. Medical records, including demographic information and pregnancy outcomes, were collected, and analyzed.\u0000\u0000Results: The prevalence of snoring was 31.4% in the third trimester of pregnancy of which 27% were pregnancy onset snoring and 4.4% were chronic onset snoring. Habitual snoring was significantly different from non-snoring in regard to the requirement for positive-pressure ventilation in newborns (aOR 6.67, 95% CI 1.2 to 35.54). The high risk group had significantly more pregnancy induced hypertension than the low risk group (aOR 5.96, 95% CI 2.15 to 16.5), gestational hypertension (aOR 13.6, 95% CI 2.1 to 86.8), preeclampsia (aOR 4.07, 95% CI 1.09 to 15.2), severe preeclampsia (aOR 4.9, 95% CI 1.15 to 20.93), preterm birth (aOR 6.21, 95% CI 1.58 to 24.42), and low birth weight of newborn (aOR 6.09, 95% CI 2.5 to 14.87).\u0000\u0000Conclusion: The prevalence of snoring among Thai pregnant women was comparable to previous Western studies. Screening pregnant women at risk of the symptom may provide an early chance to lower the prevalence of snoring and adverse pregnancy outcomes.\u0000\u0000Keywords: Snoring; Snoring in pregnancy; Pregnancy outcomes","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75426169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of COVID-19 Self-Risk Assessment Tool for Infection Prevention among Working-Age Population COVID-19自我风险评估工具在劳动年龄人群中预防感染的有效性
Q4 Medicine Pub Date : 2023-06-15 DOI: 10.35755/jmedassocthai.2023.06.13860
Background: Given the ongoing impact of the COVID-19 pandemic, self-risk assessment tools are crucial for individuals, particularly the working-age group, to evaluate their infection risk. There is a lack of such tools as of early 2021.Objective: To develop and evaluate the effectiveness of the self-assessment test application named Thai Save Thai (TST) for determining individuals’ risk level of COVID-19 infection before entering premises.Materials and Methods: The present research consisted of two phases between April 2021 and July 2022. In the first phase, factory workers from all regions of the country were recruited using population allocation sampling. TST was used for self-assessment three times within two-week period to determine risk levels. The second phase evaluated the sensitivity, specificity and predictive value of TST among 320 subjects underwent reverse transcription polymerase chain reaction (RT-PCR) testing.Results: TST showed varying percentages for each risk level: normal, 44.4%, 38.8%, 29.2%; low, 54.3%, 60.8%, 70.5%; high, 0.2%, 0.02%, 0.1%; very high, 1.1%, 0.36%, 0.21%; and infection results, 0.02%, 0%, 0.05%. TST indicated a sensitivity of 95.7% (95% CI 87.3 to 104.0), a specificity of 75.0% (95% CI 63.2 to 86.8) for detecting infection. Sensitivity for very high-risk level was 85.7% (95% CI 59.8 to 111.6) with 63.9% specificity (95% CI 51.9 to 76.0). The high-risk level had a sensitivity of 75% (95% CI 32.6 to 117) with specificity of 28.1% (95% CI 20.6 to 35.5), while the low-risk level had sensitivity of 90% (95% CI 71.4 to 109.0) with specificity of 27.1% (95% CI 19.8 to 34.3). The negative predictive value (NPV) were the same value as 97.5% at all results.Conclusion: TST application is a self-risk screening tool that effectively discriminates between different risk levels and provides sensitivity for detecting infection with NPV for all assessment results. This application can enable individuals to assess their risk level of COVID-19 infection before entering any premises.Keywords: Self-risk assessment; COVID-19; Infection; Verify of entry; Working-age
背景:鉴于2019冠状病毒病大流行的持续影响,自我风险评估工具对于个人,特别是工作年龄群体,评估其感染风险至关重要。到2021年初,还缺乏这样的工具。目的:开发并评价泰铢自评测试应用程序(TST)在个人进入场所前确定COVID-19感染风险水平的有效性。材料与方法:本研究分为2021年4月至2022年7月两个阶段。在第一阶段,采用人口分配抽样方法从全国所有地区招募工厂工人。TST在两周内进行三次自我评估,以确定风险水平。第二阶段对320名接受逆转录聚合酶链反应(RT-PCR)检测的受试者进行TST的敏感性、特异性和预测值评估。结果:TST在不同危险水平中所占比例不同:正常、44.4%、38.8%、29.2%;低,54.3%,60.8%,70.5%;高,0.2%,0.02%,0.1%;非常高,1.1%,0.36%,0.21%;感染结果分别为0.02%、0%、0.05%。TST检测感染的敏感性为95.7% (95% CI 87.3 ~ 104.0),特异性为75.0% (95% CI 63.2 ~ 86.8)。高危水平的敏感性为85.7% (95% CI 59.8 ~ 111.6),特异性为63.9% (95% CI 51.9 ~ 76.0)。高危水平的敏感性为75% (95% CI 32.6 ~ 117),特异性为28.1% (95% CI 20.6 ~ 35.5),低危水平的敏感性为90% (95% CI 71.4 ~ 109.0),特异性为27.1% (95% CI 19.8 ~ 34.3)。阴性预测值(NPV)均为97.5%。结论:TST应用是一种自我风险筛查工具,可有效区分不同风险水平,并对所有评估结果提供检测NPV感染的敏感性。该应用程序可以使个人在进入任何场所之前评估其感染COVID-19的风险水平。关键词:自我风险评估;COVID-19;感染;入境证明;工作年龄
{"title":"Effectiveness of COVID-19 Self-Risk Assessment Tool for Infection Prevention among Working-Age Population","authors":"","doi":"10.35755/jmedassocthai.2023.06.13860","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.06.13860","url":null,"abstract":"Background: Given the ongoing impact of the COVID-19 pandemic, self-risk assessment tools are crucial for individuals, particularly the working-age group, to evaluate their infection risk. There is a lack of such tools as of early 2021.\u0000\u0000Objective: To develop and evaluate the effectiveness of the self-assessment test application named Thai Save Thai (TST) for determining individuals’ risk level of COVID-19 infection before entering premises.\u0000\u0000Materials and Methods: The present research consisted of two phases between April 2021 and July 2022. In the first phase, factory workers from all regions of the country were recruited using population allocation sampling. TST was used for self-assessment three times within two-week period to determine risk levels. The second phase evaluated the sensitivity, specificity and predictive value of TST among 320 subjects underwent reverse transcription polymerase chain reaction (RT-PCR) testing.\u0000\u0000Results: TST showed varying percentages for each risk level: normal, 44.4%, 38.8%, 29.2%; low, 54.3%, 60.8%, 70.5%; high, 0.2%, 0.02%, 0.1%; very high, 1.1%, 0.36%, 0.21%; and infection results, 0.02%, 0%, 0.05%. TST indicated a sensitivity of 95.7% (95% CI 87.3 to 104.0), a specificity of 75.0% (95% CI 63.2 to 86.8) for detecting infection. Sensitivity for very high-risk level was 85.7% (95% CI 59.8 to 111.6) with 63.9% specificity (95% CI 51.9 to 76.0). The high-risk level had a sensitivity of 75% (95% CI 32.6 to 117) with specificity of 28.1% (95% CI 20.6 to 35.5), while the low-risk level had sensitivity of 90% (95% CI 71.4 to 109.0) with specificity of 27.1% (95% CI 19.8 to 34.3). The negative predictive value (NPV) were the same value as 97.5% at all results.\u0000\u0000Conclusion: TST application is a self-risk screening tool that effectively discriminates between different risk levels and provides sensitivity for detecting infection with NPV for all assessment results. This application can enable individuals to assess their risk level of COVID-19 infection before entering any premises.\u0000\u0000Keywords: Self-risk assessment; COVID-19; Infection; Verify of entry; Working-age","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91009966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chest Radiograph Findings Monitoring with Time Course of COVID-19 Pediatrics Patients 新冠肺炎儿科患者胸片表现随时间变化的监测
Q4 Medicine Pub Date : 2023-06-15 DOI: 10.35755/jmedassocthai.2023.06.13854
Na
Objective: To study image findings in covid pediatric patients, both in the first diagnosis images and follow-up images to see disease progression over time.Materials and Methods: The present research was conducted in all pediatric patients aged 0 to 18 years diagnosed as Covid-19 infection and admitted at Phramongkutklao Hospital during the study period. Image findings were retrospectively reviewed by an experienced pediatric radiologist and Brixia score was given. The maximum severity score and timing to reach this score were calculated and recorded in all patients.Results: During the study period, 428 films were collected from 170 patients. Most patients were male with a mean age of 9.89 years. Most common presenting symptom was fever. One-fourth of the studied patients had underlying illnesses. Most patients were symptomatic patients with 156 out of 170 (91.8%). The first X-ray showed abnormalities in 64.7% of symptomatic group and 42.9% in asymptomatic group. Common lobes of lungs involved were middle and lower lobes, which was slightly right-side predominate. Mean Brixia score was 2.79 (0 to 12) and 2.97 (0 to 14) in asymptomatic and symptomatic patients, respectively, which was not statistically significant. Time to reach maximum severity score was phase 1 (0 to 4 days) for symptomatic patients and phase 2 (5 to 8 days) for asymptomatic ones. For patients with normal first X-ray, abnormalities could be detected on later films, mostly in phase 1 and 2.Conclusion: Screening X-ray at the first diagnosis had high rates of abnormality detection regardless of symptom. For patients with normal first X-ray, abnormalities could be detected on later films, mostly in phase 1 and 2. Therefore, even with the fear of unnecessary exposure to radiation in children, X-ray should be performed at the first diagnosis regardless of symptom. Appropriate timing to follow-up X-ray was phase 2, at day 5 to 8 of disease.Keywords: Covid 19 X-ray; Covid in children; X-ray of pediatric covid
目的:研究covid儿童患者的影像学表现,包括首次诊断图像和随访图像,以了解疾病随时间的进展。材料与方法:本研究纳入研究期间在Phramongkutklao医院确诊为Covid-19感染的所有0 - 18岁儿童患者。影像结果由经验丰富的儿科放射科医生回顾并给予Brixia评分。计算并记录所有患者的最大严重程度评分和达到该评分的时间。结果:在研究期间,共收集170例患者的428张胶片。患者以男性为主,平均年龄9.89岁。最常见的症状是发烧。四分之一的被研究患者有潜在疾病。170例患者中有症状者最多,156例(91.8%)。有症状组64.7%、无症状组42.9%首次x线检查异常。常见的受累肺叶为中、下肺叶,以略右侧为主。无症状组和有症状组的平均Brixia评分分别为2.79(0 ~ 12)和2.97(0 ~ 14),差异无统计学意义。达到最大严重程度评分的时间为有症状患者的1期(0 ~ 4天),无症状患者的2期(5 ~ 8天)。对于第一次x线片正常的患者,在随后的x线片上可以发现异常,主要是在第1期和第2期。结论:不论症状如何,首次诊断时x线筛查异常检出率高。对于第一次x线片正常的患者,在随后的x线片上可以发现异常,主要是在第1期和第2期。因此,即使担心儿童受到不必要的辐射照射,在第一次诊断时也应进行x光检查,无论症状如何。随访x线的适当时间为第2阶段,在疾病的第5天至第8天。关键词:Covid - 19 x射线;儿童感染Covid;小儿covid x线检查
{"title":"Chest Radiograph Findings Monitoring with Time Course of COVID-19 Pediatrics Patients","authors":"Na","doi":"10.35755/jmedassocthai.2023.06.13854","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.06.13854","url":null,"abstract":"Objective: To study image findings in covid pediatric patients, both in the first diagnosis images and follow-up images to see disease progression over time.\u0000\u0000Materials and Methods: The present research was conducted in all pediatric patients aged 0 to 18 years diagnosed as Covid-19 infection and admitted at Phramongkutklao Hospital during the study period. Image findings were retrospectively reviewed by an experienced pediatric radiologist and Brixia score was given. The maximum severity score and timing to reach this score were calculated and recorded in all patients.\u0000\u0000Results: During the study period, 428 films were collected from 170 patients. Most patients were male with a mean age of 9.89 years. Most common presenting symptom was fever. One-fourth of the studied patients had underlying illnesses. Most patients were symptomatic patients with 156 out of 170 (91.8%). The first X-ray showed abnormalities in 64.7% of symptomatic group and 42.9% in asymptomatic group. Common lobes of lungs involved were middle and lower lobes, which was slightly right-side predominate. Mean Brixia score was 2.79 (0 to 12) and 2.97 (0 to 14) in asymptomatic and symptomatic patients, respectively, which was not statistically significant. Time to reach maximum severity score was phase 1 (0 to 4 days) for symptomatic patients and phase 2 (5 to 8 days) for asymptomatic ones. For patients with normal first X-ray, abnormalities could be detected on later films, mostly in phase 1 and 2.\u0000\u0000Conclusion: Screening X-ray at the first diagnosis had high rates of abnormality detection regardless of symptom. For patients with normal first X-ray, abnormalities could be detected on later films, mostly in phase 1 and 2. Therefore, even with the fear of unnecessary exposure to radiation in children, X-ray should be performed at the first diagnosis regardless of symptom. Appropriate timing to follow-up X-ray was phase 2, at day 5 to 8 of disease.\u0000\u0000Keywords: Covid 19 X-ray; Covid in children; X-ray of pediatric covid","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84747842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Pulmonary Arterial Hypertension and Risk Factors in End Stage Renal Disease Patients with Peritoneal Dialysis and Hemodialysis 终末期肾脏疾病腹膜透析与血液透析患者肺动脉高压及危险因素的比较
Q4 Medicine Pub Date : 2023-06-15 DOI: 10.35755/jmedassocthai.2023.06.13858
Background: Pulmonary arterial hypertension (PAH) is associated with high mortality and frequent complications in end stage renal disease patients. Epidemiological data for this disorder across the spectrum of end stage renal disease in Thai patients is limited.Objective: To compare the prevalence and risk factors of PAH in hemodialysis and peritoneal dialysis in end stage renal disease among the Thai patients.Materials and Methods: The authors retrospectively studied in patients with end stage renal disease at Pranangklao Hospital between January 2016 and December 2021.Results: A total of 201 patients were enrolled. The average age of patients was 55.57±16.22 years (47.3% male). Most patients had hypertension. Most patients had been prescribed folic acid. The number of patients with mean pulmonary artery pressure >20 mmHg was 81 (77.1%) in the hemodialysis group and 52 (54.2%) in the peritoneal dialysis group (p<0.001). PAH in hemodialysis was higher than peritoneal dialysis (OR 2.86, 95% CI 1.56 to 5.24, p<0.001). The following were factors associated with PAH: history of coronary artery disease (OR 2.77, 95% CI 1.29 to 5.94, p<0.009), history of beta-blocker use (OR 2.09, 95% CI 1.15 to 3.79, p<0.015), left ventricular ejection fraction by Simpson’s method (OR 0.95, 95% CI 0.92 to 0.98, p<0.001). The variable associated with PAH (peritoneal dialysis group) in multivariate logistic regression was Hemodialysis (adjusted OR 3.16, 95% CI 1.66 to 6.03, p<0.001).Conclusion: End stage renal disease in Thai patients undergoing hemodialysis carry a three-fold risk of pulmonary hypertension than peritoneal dialysis patients.Keywords: Pulmonary hypertension; Hemodialysis; Peritoneal dialysis
背景:肺动脉高压(PAH)与终末期肾病患者的高死亡率和频繁并发症相关。这种疾病在泰国终末期肾病患者中的流行病学数据是有限的。目的:比较泰国终末期肾病患者血液透析和腹膜透析中PAH的患病率及危险因素。材料和方法:作者回顾性研究了2016年1月至2021年12月在Pranangklao医院就诊的终末期肾病患者。结果:共纳入201例患者。患者平均年龄55.57±16.22岁,男性占47.3%。大多数患者有高血压。大多数患者都服用了叶酸。血液透析组平均肺动脉压> 20mmhg的患者为81例(77.1%),腹膜透析组为52例(54.2%)(p<0.001)。血液透析组PAH高于腹膜透析组(OR 2.86, 95% CI 1.56 ~ 5.24, p<0.001)。以下是与PAH相关的因素:冠状动脉疾病史(OR 2.77, 95% CI 1.29 ~ 5.94, p<0.009), β受体阻滞剂使用史(OR 2.09, 95% CI 1.15 ~ 3.79, p<0.015),辛普森法左心室射血分数(OR 0.95, 95% CI 0.92 ~ 0.98, p<0.001)。在多因素logistic回归中,与PAH(腹膜透析组)相关的变量是血液透析(校正OR 3.16, 95% CI 1.66 ~ 6.03, p<0.001)。结论:终末期肾病患者接受血液透析的肺动脉高压风险是腹膜透析患者的三倍。关键词:肺动脉高压;血液透析;腹膜透析
{"title":"Comparison of Pulmonary Arterial Hypertension and Risk Factors in End Stage Renal Disease Patients with Peritoneal Dialysis and Hemodialysis","authors":"","doi":"10.35755/jmedassocthai.2023.06.13858","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.06.13858","url":null,"abstract":"Background: Pulmonary arterial hypertension (PAH) is associated with high mortality and frequent complications in end stage renal disease patients. Epidemiological data for this disorder across the spectrum of end stage renal disease in Thai patients is limited.\u0000\u0000Objective: To compare the prevalence and risk factors of PAH in hemodialysis and peritoneal dialysis in end stage renal disease among the Thai patients.\u0000\u0000Materials and Methods: The authors retrospectively studied in patients with end stage renal disease at Pranangklao Hospital between January 2016 and December 2021.\u0000\u0000Results: A total of 201 patients were enrolled. The average age of patients was 55.57±16.22 years (47.3% male). Most patients had hypertension. Most patients had been prescribed folic acid. The number of patients with mean pulmonary artery pressure >20 mmHg was 81 (77.1%) in the hemodialysis group and 52 (54.2%) in the peritoneal dialysis group (p<0.001). PAH in hemodialysis was higher than peritoneal dialysis (OR 2.86, 95% CI 1.56 to 5.24, p<0.001). The following were factors associated with PAH: history of coronary artery disease (OR 2.77, 95% CI 1.29 to 5.94, p<0.009), history of beta-blocker use (OR 2.09, 95% CI 1.15 to 3.79, p<0.015), left ventricular ejection fraction by Simpson’s method (OR 0.95, 95% CI 0.92 to 0.98, p<0.001). The variable associated with PAH (peritoneal dialysis group) in multivariate logistic regression was Hemodialysis (adjusted OR 3.16, 95% CI 1.66 to 6.03, p<0.001).\u0000\u0000Conclusion: End stage renal disease in Thai patients undergoing hemodialysis carry a three-fold risk of pulmonary hypertension than peritoneal dialysis patients.\u0000\u0000Keywords: Pulmonary hypertension; Hemodialysis; Peritoneal dialysis","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83168141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Outcomes of Superficial Parotidectomy with Intraoperative Facial Nerve Monitoring: Experience in Sawanpracharak Hospital 2020 to 2022 术中面神经监测下腮腺浅表性切除术的效果:沙文普拉恰拉克医院2020 ~ 2022年的经验
Q4 Medicine Pub Date : 2023-06-15 DOI: 10.35755/jmedassocthai.2023.06.13861
Objective: To determine the outcomes of patients undergone parotidectomy with or without facial nerve monitoring.Materials and Methods: The present study was a retrospective study that included 35 patients underwent superficial parotidectomy with pathologic findings of benign parotid tumor. The patients were divided into two groups. Intraoperative facial nerve monitoring was performed in 15 patients and did not monitor in 20 patients. Data were compared between the surgical groups with intraoperative facial nerve monitoring and the groups without intraoperative facial nerve monitoring using the chi-square test and independent t-test.Results: Patients who underwent parotidectomy between January 1, 2020 and December 31, 2022, whose pathologic findings were benign, a total of 35 cases were divided into 15 patients underwent surgery with intraoperative facial nerve monitoring and 20 patients underwent surgery without intraoperative facial nerve monitoring. There was no statistical difference in operation time and saliva leakage. However, there was a statistical difference in intraoperative blood loss, postoperative facial nerve weakness rate, and postoperative earlobe numbness.Conclusion: The most common complication of parotidectomy is paralysis of the facial nerve. The present study showed that intraoperative facial nerve monitoring can reduce facial nerve paralysis, blood loss during surgery and postoperative earlobe numbness.Keywords: Intraoperative facial nerve monitoring; Parotidectomy; Parotid tumor
目的:探讨面神经监测对腮腺切除术患者预后的影响。材料与方法:本研究是一项回顾性研究,包括35例经腮腺浅表性切除术的患者,病理表现为腮腺良性肿瘤。患者被分为两组。术中面神经监测15例,未监测20例。采用卡方检验和独立t检验比较术中监测面神经的手术组与未监测面神经的手术组的数据。结果:2020年1月1日至2022年12月31日行腮腺切除术的患者,病理表现均为良性,共35例,其中术中有面神经监测的15例,术中无面神经监测的20例。两组手术时间及唾液漏出无统计学差异。两组术中出血量、术后面神经无力率、术后耳垂麻木程度差异有统计学意义。结论:腮腺切除术最常见的并发症是面神经麻痹。本研究表明术中面神经监测可以减少面神经麻痹、术中失血和术后耳垂麻木。关键词:术中面神经监测;腮腺切除术;腮腺肿瘤
{"title":"The Outcomes of Superficial Parotidectomy with Intraoperative Facial Nerve Monitoring: Experience in Sawanpracharak Hospital 2020 to 2022","authors":"","doi":"10.35755/jmedassocthai.2023.06.13861","DOIUrl":"https://doi.org/10.35755/jmedassocthai.2023.06.13861","url":null,"abstract":"Objective: To determine the outcomes of patients undergone parotidectomy with or without facial nerve monitoring.\u0000\u0000Materials and Methods: The present study was a retrospective study that included 35 patients underwent superficial parotidectomy with pathologic findings of benign parotid tumor. The patients were divided into two groups. Intraoperative facial nerve monitoring was performed in 15 patients and did not monitor in 20 patients. Data were compared between the surgical groups with intraoperative facial nerve monitoring and the groups without intraoperative facial nerve monitoring using the chi-square test and independent t-test.\u0000\u0000Results: Patients who underwent parotidectomy between January 1, 2020 and December 31, 2022, whose pathologic findings were benign, a total of 35 cases were divided into 15 patients underwent surgery with intraoperative facial nerve monitoring and 20 patients underwent surgery without intraoperative facial nerve monitoring. There was no statistical difference in operation time and saliva leakage. However, there was a statistical difference in intraoperative blood loss, postoperative facial nerve weakness rate, and postoperative earlobe numbness.\u0000\u0000Conclusion: The most common complication of parotidectomy is paralysis of the facial nerve. The present study showed that intraoperative facial nerve monitoring can reduce facial nerve paralysis, blood loss during surgery and postoperative earlobe numbness.\u0000\u0000Keywords: Intraoperative facial nerve monitoring; Parotidectomy; Parotid tumor","PeriodicalId":17486,"journal":{"name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77119238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1