: Seborrheic dermatitis (SD) is a common disorder of the skin, which is dermatologically manifested by erythematous patches covered by yellow-grey scales. It mostly appears on the face, scalp, upper chest, and back. Half of the adult population is estimated to be affected by seborrheic dermatitis of the scalp. Although its prevalence is very high, the etiology has not been very well known. Numerous intrinsic and external environmental factors such as excessive sebum secretions, fungal colonization of the surface of the skin, genetic susceptibility, and dynamics, among others, can result in the development of the disease. Unani medicine is familiar with this disease under the entity named ‘Tasherul Raas/Huzaz’. Various herbal and mineral-origin drugs have been declared in the Unani classical literature for the treatment of SD. In the present paper, topical Unani drugs particularly beneficial for scalp seborrheic dermatitis are discussed.
{"title":"Antifungal Topical Drugs for Seborrheic Dermatitis of Scalp in Unani Medicine","authors":"Shabnam Ansari, I. Ahmad, S. Alam, S. Alam","doi":"10.5812/jssc.105233","DOIUrl":"https://doi.org/10.5812/jssc.105233","url":null,"abstract":": Seborrheic dermatitis (SD) is a common disorder of the skin, which is dermatologically manifested by erythematous patches covered by yellow-grey scales. It mostly appears on the face, scalp, upper chest, and back. Half of the adult population is estimated to be affected by seborrheic dermatitis of the scalp. Although its prevalence is very high, the etiology has not been very well known. Numerous intrinsic and external environmental factors such as excessive sebum secretions, fungal colonization of the surface of the skin, genetic susceptibility, and dynamics, among others, can result in the development of the disease. Unani medicine is familiar with this disease under the entity named ‘Tasherul Raas/Huzaz’. Various herbal and mineral-origin drugs have been declared in the Unani classical literature for the treatment of SD. In the present paper, topical Unani drugs particularly beneficial for scalp seborrheic dermatitis are discussed.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122511171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Linear atrophoderma of Moulin (LAM) is a rare dermatologic disorder characterized by hyperpigmented atrophic plaques following the Blaschko lines (BL). The trunk and limbs are the usual sites affected. Isolated facial involvement is an exceedingly rare entity. Despite a comprehensive medical literature search, the author could find only two cases of LAM where the lesions are exclusively localized to the face. In this article, the author presents the third case of LAM localized to face only. Case Presentation: A 26-year-old male complained of multiple linear non-pruritic pigmented lesions over the left side of the nose and glabellar area of six months’ duration. There was no history of erythema, thickening/hardening of skin, or violaceous border surrounding the lesions. On clinical examination, there were multiple hyperpigmented brownish lesions, the majority of which were depressed, involving the left ala and bridge of nose laterally and glabellar area in a Blaschkoid pattern. Diagnosis of LAM was established based on suggestive history and clinical examination. Conclusions: LAM is a rare disorder, and the facial localization makes it exceedingly rare. It should be kept in the differential diagnosis when hyperpigmented depressed lesions are present in a Blaschkoid pattern on the face.
{"title":"Linear Atrophoderma of Moulin Localized to Face: An Exceedingly Rare Entity","authors":"T. Arif","doi":"10.5812/jssc.106255","DOIUrl":"https://doi.org/10.5812/jssc.106255","url":null,"abstract":"Introduction: Linear atrophoderma of Moulin (LAM) is a rare dermatologic disorder characterized by hyperpigmented atrophic plaques following the Blaschko lines (BL). The trunk and limbs are the usual sites affected. Isolated facial involvement is an exceedingly rare entity. Despite a comprehensive medical literature search, the author could find only two cases of LAM where the lesions are exclusively localized to the face. In this article, the author presents the third case of LAM localized to face only. Case Presentation: A 26-year-old male complained of multiple linear non-pruritic pigmented lesions over the left side of the nose and glabellar area of six months’ duration. There was no history of erythema, thickening/hardening of skin, or violaceous border surrounding the lesions. On clinical examination, there were multiple hyperpigmented brownish lesions, the majority of which were depressed, involving the left ala and bridge of nose laterally and glabellar area in a Blaschkoid pattern. Diagnosis of LAM was established based on suggestive history and clinical examination. Conclusions: LAM is a rare disorder, and the facial localization makes it exceedingly rare. It should be kept in the differential diagnosis when hyperpigmented depressed lesions are present in a Blaschkoid pattern on the face.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125241897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Belgaumkar, R. Chavan, N. Deshmukh, Nupur Vasudeo Warke
Background: Vitiligo is a common, acquired, mucocutaneous discoloration characterized by well-circumscribed depigmented macules. It has profound potential for cosmetic disfigurement and social stigma, which is an often neglected aspect of the disease. Objectives: To analyze the impact of vitiligo on the quality of life (Qol) of patients in western India and To determine the contributory factors. Methods: A cross-sectional, observational study was conducted at a tertiary care hospital on 60 patients with vitiligo (were enrolled after informed consent and ethical approval). Basic patient-related (age, gender, socioeconomic status, co-morbidities) and vitiligo-related variables (body surface area involved, stability, duration of disease, treatment modality) were noted. This information were collated with QoL using a standardized questionnaire, the Dermatology Life Quality Index (DLQI). Statistical analysis was performed using Spearman’s rank correlation coefficient, Pearson’s r, unpaired t-test (SPSS version 16). Results: Mean DLQI score of the study sample was 3.15 ± 4.2 (small effect on QoL). The mean DLQI score in females (3.97) was significantly higher than in males (1.92) (P = 0.046). Also, the DLQI demonstrated a significant positive correlation with body surface area involvement (Spearman’s correlation coefficient = 0.306) (P = 0.018). Other factors were not found to affect the DLQI. Conclusions: Various modifiable and non-modifiable factors influence the QoL of vitiligo patients. Gender- associated stigma may be alleviated by counseling and creating awareness, while the body surface area involvement may be addressed by instituting early and appropriate treatment. The clinician must be vigilant for any subtle signs of impairment of QoL to enable timely intervention.
背景:白癜风是一种常见的、获得性的皮肤粘膜变色，其特征是界限分明的色素沉着斑。它对美容毁容和社会耻辱具有深远的潜力，这是该疾病经常被忽视的一个方面。目的:分析白癜风对印度西部地区患者生活质量的影响，探讨其影响因素。方法:在一家三级医院对60例白癜风患者进行横断面观察性研究(经知情同意和伦理批准后入组)。记录了与患者相关的基本变量(年龄、性别、社会经济地位、合并症)和与白癜风相关的变量(涉及的体表面积、稳定性、疾病持续时间、治疗方式)。使用标准化问卷皮肤病生活质量指数(DLQI)将这些信息与生活质量进行核对。统计学分析采用Spearman’s秩相关系数、Pearson’s r、unpaired t检验(SPSS version 16)。结果:研究样本DLQI平均评分为3.15±4.2分(对生活质量影响较小)。女性DLQI平均评分(3.97)明显高于男性(1.92)(P = 0.046)。DLQI与体表受累呈显著正相关(Spearman相关系数= 0.306)(P = 0.018)。其他因素未发现影响DLQI。结论:各种可改变和不可改变的因素影响白癜风患者的生活质量。与性别相关的耻辱感可以通过咨询和提高意识来缓解，而体表受病可以通过早期和适当的治疗来解决。临床医生必须对生活质量受损的任何细微迹象保持警惕，以便及时干预。
{"title":"Impact of Vitiligo on Quality of Life: A Cross-sectional Pilot Study from Western India","authors":"V. Belgaumkar, R. Chavan, N. Deshmukh, Nupur Vasudeo Warke","doi":"10.5812/jssc.107184","DOIUrl":"https://doi.org/10.5812/jssc.107184","url":null,"abstract":"Background: Vitiligo is a common, acquired, mucocutaneous discoloration characterized by well-circumscribed depigmented macules. It has profound potential for cosmetic disfigurement and social stigma, which is an often neglected aspect of the disease. Objectives: To analyze the impact of vitiligo on the quality of life (Qol) of patients in western India and To determine the contributory factors. Methods: A cross-sectional, observational study was conducted at a tertiary care hospital on 60 patients with vitiligo (were enrolled after informed consent and ethical approval). Basic patient-related (age, gender, socioeconomic status, co-morbidities) and vitiligo-related variables (body surface area involved, stability, duration of disease, treatment modality) were noted. This information were collated with QoL using a standardized questionnaire, the Dermatology Life Quality Index (DLQI). Statistical analysis was performed using Spearman’s rank correlation coefficient, Pearson’s r, unpaired t-test (SPSS version 16). Results: Mean DLQI score of the study sample was 3.15 ± 4.2 (small effect on QoL). The mean DLQI score in females (3.97) was significantly higher than in males (1.92) (P = 0.046). Also, the DLQI demonstrated a significant positive correlation with body surface area involvement (Spearman’s correlation coefficient = 0.306) (P = 0.018). Other factors were not found to affect the DLQI. Conclusions: Various modifiable and non-modifiable factors influence the QoL of vitiligo patients. Gender- associated stigma may be alleviated by counseling and creating awareness, while the body surface area involvement may be addressed by instituting early and appropriate treatment. The clinician must be vigilant for any subtle signs of impairment of QoL to enable timely intervention.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130596871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Anetoderma is an elastolytic disorder, categorized by singular or multiple areas of macules or papules, which can lead to the herniation of subcutaneous tissue. Anetoderma is rare, and its incidence is unknown. Primary anetoderma or idiopathic anetoderma occurs when there is no underlying associated skin disease with unknown pathogenesis. It can be classified into two major forms: (A) the Jadassohn-Pellizzari type and (B) the Schweninger-Buzzi type. Little is known about the specific pathophysiologic processes underlying anetoderma, although the phagocytic destruction of the elastic fibers has been postulated as a major role-player in the lesions. Our case highlights the incidence of primary anetoderma in a Southeast Asian adolescent girl with the onset during infancy that spread throughout the child’s development, without a family history of the disease.
{"title":"Primary Anetoderma in an Infant: A Case Report From Southeast Asia","authors":"M. Ghaznawie, Raymond Widjajahakim, I. Effendy","doi":"10.5812/jssc.102241","DOIUrl":"https://doi.org/10.5812/jssc.102241","url":null,"abstract":": Anetoderma is an elastolytic disorder, categorized by singular or multiple areas of macules or papules, which can lead to the herniation of subcutaneous tissue. Anetoderma is rare, and its incidence is unknown. Primary anetoderma or idiopathic anetoderma occurs when there is no underlying associated skin disease with unknown pathogenesis. It can be classified into two major forms: (A) the Jadassohn-Pellizzari type and (B) the Schweninger-Buzzi type. Little is known about the specific pathophysiologic processes underlying anetoderma, although the phagocytic destruction of the elastic fibers has been postulated as a major role-player in the lesions. Our case highlights the incidence of primary anetoderma in a Southeast Asian adolescent girl with the onset during infancy that spread throughout the child’s development, without a family history of the disease.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115822813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The number of skin biopsies has increased over the last three decades, but benchmarks based on the number of biopsies required to capture skin cancers are lacking. To determine the most common dermatopathology diagnoses, reports of all 85,785 dermatopathology specimens examined in the Department of Dermatology at the University of Florida from January 2017 to December 2017 were reviewed. 78,353 non-excisional specimens were evaluated for diagnosis. 7,432 excisional specimens consisting of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and dysplastic nevi were evaluated for residual tumor and marginal status. The fifteen most common diagnoses accounted for 84% of all biopsies, and an additional 30 entities accounted for 12% of all biopsies. The remaining 4% of cases were composed of only 206 diagnoses. This pattern reflects current dermatology practice in the United States, wherein the 20 most commonly encountered diseases account for 85.4% of all diagnoses made by dermatologists. Among the total number of biopsies, 90.7% of specimens were neoplasms and 9.3% were inflammatory or infectious disorders. Uncommon (4%) and inflammatory or infectious (9.3%) disorders comprise a small minority of academic dermatopathology, with implications for resident and fellowship training.
{"title":"Analysis of the Most Commonly Encountered Diagnoses in Academic Dermatopathology","authors":"V. Vincek, E. Rudnick, K. Motaparthi, A. Walker","doi":"10.5812/jssc.105911","DOIUrl":"https://doi.org/10.5812/jssc.105911","url":null,"abstract":": The number of skin biopsies has increased over the last three decades, but benchmarks based on the number of biopsies required to capture skin cancers are lacking. To determine the most common dermatopathology diagnoses, reports of all 85,785 dermatopathology specimens examined in the Department of Dermatology at the University of Florida from January 2017 to December 2017 were reviewed. 78,353 non-excisional specimens were evaluated for diagnosis. 7,432 excisional specimens consisting of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and dysplastic nevi were evaluated for residual tumor and marginal status. The fifteen most common diagnoses accounted for 84% of all biopsies, and an additional 30 entities accounted for 12% of all biopsies. The remaining 4% of cases were composed of only 206 diagnoses. This pattern reflects current dermatology practice in the United States, wherein the 20 most commonly encountered diseases account for 85.4% of all diagnoses made by dermatologists. Among the total number of biopsies, 90.7% of specimens were neoplasms and 9.3% were inflammatory or infectious disorders. Uncommon (4%) and inflammatory or infectious (9.3%) disorders comprise a small minority of academic dermatopathology, with implications for resident and fellowship training.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117162631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kamil, N. Nor, C. Ngiu, M. R. A. Manaf, S. Thevarajah, A. Jamil, M. Arumugam
Background: Psoriasis patients have an increased risk for non-alcoholic fatty liver disease (NAFLD). Controlled attenuation parameter (CAP) on transient elastography is more sensitive than abdominal ultrasonography in detecting liver steatosis. Objectives: To determine the prevalence of NAFLD in psoriasis and to identify its predisposing factors. Methods: A cross-sectional study was performed involving 109 psoriasis patients aged > 18 years in two tertiary dermatology clinics in Kuala Lumpur. Patients on hepatotoxic drugs, had excessive alcohol intake, and other secondary causes of chronic liver diseases were excluded. Anthropometrics, blood pressure, Psoriasis Area and Severity Index (PASI), liver function test, lipid profile, and fasting blood glucose were obtained. CAP on transient elastography was performed to diagnose NAFLD. The clinical characteristics of psoriasis patients were compared between patients with and without NAFLD. Results: The prevalence of NAFLD was 85.3%. NAFLD in psoriasis patients was associated with a higher weight (P < 0.0005), body mass index (BMI) (P < 0.0005), waist circumference (P < 0.0005), and metabolic syndrome (P = 0.002). Fasting blood glucose (5.3 [1.8] mmol/L, p=0.010), triglyceride (1.4 [0.8] mmol/L, P < 0.0005), and alanine transaminase (28.5 [26] U/L, P = 0.001) were higher in patients with NAFLD compared with those without it. PASI and systolic blood pressure correlated significantly with NAFLD severity. BMI (OR = 1.63, 95% CI: 1.127 - 2.357, P = 0.009), triglyceride level (OR = 130.74, 95% CI = 2.94 - 812, P = 0.012), and PASI (OR = 1.138, 95% CI = 1.004 - 1.290, P = 0.043) were the significant predictors of NAFLD. Conclusions: NAFLD should be screened in all psoriasis patients, especially in patients with high BMI, metabolic syndrome, and severe psoriasis, despite having a normal biochemical profile. Early detection of asymptomatic NAFLD is essential for preventive management, including to reduce hepatotoxicity risk of psoriasis pharmacotherapy.
背景:银屑病患者发生非酒精性脂肪性肝病(NAFLD)的风险增加。瞬时弹性成像控制衰减参数(CAP)对肝脏脂肪变性的检测比腹部超声更灵敏。目的:了解银屑病NAFLD的患病率，并探讨其易感因素。方法:对吉隆坡两家三级皮肤科诊所的109名年龄> 18岁的银屑病患者进行横断面研究。排除服用肝毒性药物、过量饮酒和其他继发性慢性肝病的患者。测量人体测量、血压、银屑病面积及严重程度指数(PASI)、肝功能、血脂、空腹血糖。应用瞬时弹性成像CAP诊断NAFLD。比较有无NAFLD的银屑病患者的临床特点。结果:NAFLD患病率为85.3%。牛皮癣患者NAFLD与较高的体重(P < 0.0005)、体重指数(BMI) (P < 0.0005)、腰围(P < 0.0005)和代谢综合征(P = 0.002)相关。NAFLD患者空腹血糖(5.3 [1.8]mmol/L, p=0.010)、甘油三酯(1.4 [0.8]mmol/L, p < 0.0005)、丙氨酸转氨酶(28.5 [26]U/L, p= 0.001)高于非NAFLD患者。PASI和收缩压与NAFLD严重程度显著相关。BMI (OR = 1.63, 95% CI = 1.127 ~ 2.357, P = 0.009)、甘油三酯水平(OR = 130.74, 95% CI = 2.94 ~ 812, P = 0.012)和PASI (OR = 1.138, 95% CI = 1.004 ~ 1.290, P = 0.043)是NAFLD的显著预测因子。结论:NAFLD应在所有牛皮癣患者中进行筛查，特别是高BMI、代谢综合征和严重牛皮癣患者，尽管其生化特征正常。早期发现无症状NAFLD对于预防管理至关重要，包括降低银屑病药物治疗的肝毒性风险。
{"title":"Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) Diagnosed by Controlled Attenuation Parameter on Transient Elastography and Its Predisposing Factors in Psoriasis","authors":"M. Kamil, N. Nor, C. Ngiu, M. R. A. Manaf, S. Thevarajah, A. Jamil, M. Arumugam","doi":"10.5812/jssc.103245","DOIUrl":"https://doi.org/10.5812/jssc.103245","url":null,"abstract":"Background: Psoriasis patients have an increased risk for non-alcoholic fatty liver disease (NAFLD). Controlled attenuation parameter (CAP) on transient elastography is more sensitive than abdominal ultrasonography in detecting liver steatosis. Objectives: To determine the prevalence of NAFLD in psoriasis and to identify its predisposing factors. Methods: A cross-sectional study was performed involving 109 psoriasis patients aged > 18 years in two tertiary dermatology clinics in Kuala Lumpur. Patients on hepatotoxic drugs, had excessive alcohol intake, and other secondary causes of chronic liver diseases were excluded. Anthropometrics, blood pressure, Psoriasis Area and Severity Index (PASI), liver function test, lipid profile, and fasting blood glucose were obtained. CAP on transient elastography was performed to diagnose NAFLD. The clinical characteristics of psoriasis patients were compared between patients with and without NAFLD. Results: The prevalence of NAFLD was 85.3%. NAFLD in psoriasis patients was associated with a higher weight (P < 0.0005), body mass index (BMI) (P < 0.0005), waist circumference (P < 0.0005), and metabolic syndrome (P = 0.002). Fasting blood glucose (5.3 [1.8] mmol/L, p=0.010), triglyceride (1.4 [0.8] mmol/L, P < 0.0005), and alanine transaminase (28.5 [26] U/L, P = 0.001) were higher in patients with NAFLD compared with those without it. PASI and systolic blood pressure correlated significantly with NAFLD severity. BMI (OR = 1.63, 95% CI: 1.127 - 2.357, P = 0.009), triglyceride level (OR = 130.74, 95% CI = 2.94 - 812, P = 0.012), and PASI (OR = 1.138, 95% CI = 1.004 - 1.290, P = 0.043) were the significant predictors of NAFLD. Conclusions: NAFLD should be screened in all psoriasis patients, especially in patients with high BMI, metabolic syndrome, and severe psoriasis, despite having a normal biochemical profile. Early detection of asymptomatic NAFLD is essential for preventive management, including to reduce hepatotoxicity risk of psoriasis pharmacotherapy.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128654310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: This mini review aims to describe the main physicochemical properties and characteristics of cyclodextrin derivatives (CDs) having been used in various skin-related formulations over the last nearly 50 years. Due to many misunderstandings and inconsistent data on the Internet, the basic properties of CDs, water content, solubility properties, and maximum complexing capabilities are summarized. CDs are grouped by their solubility properties and briefly described by chemical synthesis to reveal the potential contaminants. Soluble and insoluble CD-based polymers are also discussed.
{"title":"Cyclodextrins in Skin Formulations and Transdermal Delivery","authors":"L. Jicsinszky, G. Cravotto","doi":"10.5812/jssc.102561","DOIUrl":"https://doi.org/10.5812/jssc.102561","url":null,"abstract":": This mini review aims to describe the main physicochemical properties and characteristics of cyclodextrin derivatives (CDs) having been used in various skin-related formulations over the last nearly 50 years. Due to many misunderstandings and inconsistent data on the Internet, the basic properties of CDs, water content, solubility properties, and maximum complexing capabilities are summarized. CDs are grouped by their solubility properties and briefly described by chemical synthesis to reveal the potential contaminants. Soluble and insoluble CD-based polymers are also discussed.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134579130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Multiple autoimmune syndrome (MAS) is a rare syndrome in which the patient is diagnosed with three or more autoimmune diseases. Autoimmune skin disorders, such as vitiligo, alopecia areata, lupus erythematosus, Sjogren's syndrome, or dermatitis herpetiformis, often take part in MAS. The etiology of the syndrome is still unknown, but immunological, hormonal, genetic, and environmental factors possibly play a role. Case Presentation: A 63-year-old woman was admitted to our department with a rare combination of several autoimmune diseases, including vitiligo, autoimmune thyroiditis, and recently diagnosed diabetes mellitus. Although the immediate cause of her hospitalization was erysipelas of the left leg, type 3 MAS was suspected, based on the simultaneous presence of three autoimmune diseases. Type 3 MAS groups together conditions such as autoimmune thyroid disease, myasthenia gravis, thymoma, Sjogren's syndrome, pernicious anemia, idiopathic thrombocytopenic purpura, Addison’s disease, type 1 diabetes mellitus, vitiligo, autoimmune hemolytic anemia, systemic lupus erythematosus, and dermatitis herpetiformis. The only criterion that needed to be fulfilled in our case, to establish the diagnosis of type 3 MAS, was a specific subtype of diabetes, namely, late-onset autoimmune diabetes (LADA). Conclusions: We presented a patient with possible type 3 MAS. Further investigations are needed for the diagnosis of LADA by a more precise serological examination of anti-IA and anti-GAD 65 antibodies.
{"title":"Probable Multiple Autoimmune Syndrome in a Patient with Vitiligo, Autoimmune Thyroiditis, and Diabetes Mellitus: A Case Report","authors":"L. Dourmishev, J. Pozharashka, L. Miteva","doi":"10.5812/jssc.103596","DOIUrl":"https://doi.org/10.5812/jssc.103596","url":null,"abstract":"Introduction: Multiple autoimmune syndrome (MAS) is a rare syndrome in which the patient is diagnosed with three or more autoimmune diseases. Autoimmune skin disorders, such as vitiligo, alopecia areata, lupus erythematosus, Sjogren's syndrome, or dermatitis herpetiformis, often take part in MAS. The etiology of the syndrome is still unknown, but immunological, hormonal, genetic, and environmental factors possibly play a role. Case Presentation: A 63-year-old woman was admitted to our department with a rare combination of several autoimmune diseases, including vitiligo, autoimmune thyroiditis, and recently diagnosed diabetes mellitus. Although the immediate cause of her hospitalization was erysipelas of the left leg, type 3 MAS was suspected, based on the simultaneous presence of three autoimmune diseases. Type 3 MAS groups together conditions such as autoimmune thyroid disease, myasthenia gravis, thymoma, Sjogren's syndrome, pernicious anemia, idiopathic thrombocytopenic purpura, Addison’s disease, type 1 diabetes mellitus, vitiligo, autoimmune hemolytic anemia, systemic lupus erythematosus, and dermatitis herpetiformis. The only criterion that needed to be fulfilled in our case, to establish the diagnosis of type 3 MAS, was a specific subtype of diabetes, namely, late-onset autoimmune diabetes (LADA). Conclusions: We presented a patient with possible type 3 MAS. Further investigations are needed for the diagnosis of LADA by a more precise serological examination of anti-IA and anti-GAD 65 antibodies.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128261476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Izmirli, Hasret Ecevit, H. Okuyan, E. Rifaioǧlu
Background: Acne vulgaris is the most common inflammatory skin disease. It is primarily observed in adolescents and is characterized by comedones, papules, pustules, nodules, and cysts on the face, back, chest, chin, and body skin. Acne vulgaris affects about 80% of teenagers and continues beyond the age of 25 years in 3% of men and 12% of women in the world. Isotretinoin is one of themostcommontreatmentagentsforacnevulgaris, whichcausesoxidativeDNAdamageinthecell. Asanimportantindicator of oxidative DNA damage, 8-hydroxy-2’-deoxyguanosine is repaired with an enzyme called human 8-oxoguanine DNA glycosylase 1 (hOGG1). Objectives: WeaimedtoevaluateoxidativeDNAdamageinacnevulgarisbeforeandafterisotretinointreatmentbymeasuringthe 8-OHdG and hOGG1 levels. Methods: The8-OHdGandhOGG1levelswereevaluatedfromserumsamplesusingtheenzyme-linkedimmunosorbentassay(ELISA) method. Both the serum 8-OHdG (P < 0.05; P < 0.0001) and hOGG1 (P < 0.05; P = 0.04) levels were found to be statistically higher in the sixth month after isotretinoin treatment. Results: In this first report, the 8-OHdG and hOGG1 levels were found to be statistically significantly high after isotretinoin treatment. According to our results, the 8-OHdG level increased under isotretinoin administration in acne vulgaris patients. Conclusions: Consequently, healing via hOGG1 likely continues after dropping isotretinoin for DNA.
{"title":"8-OHdG and hOGG1 as Oxidative DNA Damage Markers in Acne Vulgaris Patients Under Isotretinoin Treatment","authors":"M. Izmirli, Hasret Ecevit, H. Okuyan, E. Rifaioǧlu","doi":"10.5812/jssc.103492","DOIUrl":"https://doi.org/10.5812/jssc.103492","url":null,"abstract":"Background: Acne vulgaris is the most common inflammatory skin disease. It is primarily observed in adolescents and is characterized by comedones, papules, pustules, nodules, and cysts on the face, back, chest, chin, and body skin. Acne vulgaris affects about 80% of teenagers and continues beyond the age of 25 years in 3% of men and 12% of women in the world. Isotretinoin is one of themostcommontreatmentagentsforacnevulgaris, whichcausesoxidativeDNAdamageinthecell. Asanimportantindicator of oxidative DNA damage, 8-hydroxy-2’-deoxyguanosine is repaired with an enzyme called human 8-oxoguanine DNA glycosylase 1 (hOGG1). Objectives: WeaimedtoevaluateoxidativeDNAdamageinacnevulgarisbeforeandafterisotretinointreatmentbymeasuringthe 8-OHdG and hOGG1 levels. Methods: The8-OHdGandhOGG1levelswereevaluatedfromserumsamplesusingtheenzyme-linkedimmunosorbentassay(ELISA) method. Both the serum 8-OHdG (P < 0.05; P < 0.0001) and hOGG1 (P < 0.05; P = 0.04) levels were found to be statistically higher in the sixth month after isotretinoin treatment. Results: In this first report, the 8-OHdG and hOGG1 levels were found to be statistically significantly high after isotretinoin treatment. According to our results, the 8-OHdG level increased under isotretinoin administration in acne vulgaris patients. Conclusions: Consequently, healing via hOGG1 likely continues after dropping isotretinoin for DNA.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126983332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marília Gabriele Prado Albuquerque Ferreira, Fatima Abou Ghaouche de Moraes, L. M. Prado, A. Pascoli, G. Hernandez, N. P. R. Filho, O. R. Matiz, Rafaela Bortolotti Viéra, M. Tinucci-Costa, A. B. Nardi, A. Antunes
Introduction: The present report aimed at describing an atypical presentation of a cutaneous transmissible venereal tumor (TVT) in a dog. Case Presentation: The case was admitted at the Veterinary Hospital of the Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brazil, due to the presence of multiple ulcerated, crusty, and occasionally coalescing cutaneous nodules. The disease was first diagnosed by a practitioner 15 months before the referral to the UNESP Veterinary Hospital. Thus, the dog had already been subjected to the vincristine antineoplastic chemotherapy for the treatment of cutaneous TVT 15 months ago. As a diagnostic approach, cytological, histopathological, and immunohistochemical analyses were performed. The patient was then subjected to antineoplastic chemotherapy based on vincristine, doxorubicin, and bleomycin protocols; nonetheless, it was not successful, and the patient passed away 16 months after the primary diagnosis of TVT. Conclusions: TVT can be more aggressive than usually expected, and the correct diagnosis and appropriate treatment can reduce the risk of chemotherapy resistance.
{"title":"Atypical Presentation and Aggressive Behavior of the Transmissible Venereal Tumor in a Dog: A Case Report","authors":"Marília Gabriele Prado Albuquerque Ferreira, Fatima Abou Ghaouche de Moraes, L. M. Prado, A. Pascoli, G. Hernandez, N. P. R. Filho, O. R. Matiz, Rafaela Bortolotti Viéra, M. Tinucci-Costa, A. B. Nardi, A. Antunes","doi":"10.5812/jssc.102980","DOIUrl":"https://doi.org/10.5812/jssc.102980","url":null,"abstract":"Introduction: The present report aimed at describing an atypical presentation of a cutaneous transmissible venereal tumor (TVT) in a dog. Case Presentation: The case was admitted at the Veterinary Hospital of the Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brazil, due to the presence of multiple ulcerated, crusty, and occasionally coalescing cutaneous nodules. The disease was first diagnosed by a practitioner 15 months before the referral to the UNESP Veterinary Hospital. Thus, the dog had already been subjected to the vincristine antineoplastic chemotherapy for the treatment of cutaneous TVT 15 months ago. As a diagnostic approach, cytological, histopathological, and immunohistochemical analyses were performed. The patient was then subjected to antineoplastic chemotherapy based on vincristine, doxorubicin, and bleomycin protocols; nonetheless, it was not successful, and the patient passed away 16 months after the primary diagnosis of TVT. Conclusions: TVT can be more aggressive than usually expected, and the correct diagnosis and appropriate treatment can reduce the risk of chemotherapy resistance.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114622055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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