Kopal Agrawal, V. Belgaumkar, R. Chavan, N. Deshmukh
Background: Hirsutism is defined as excess terminal hair growth over androgen-dependent areas in women. It may cause significant social and psychological stigma with a negative impact on the quality of life. However, there is a dearth of data regarding this important parameter from the Indian sub-continent. Objectives: A cross-sectional study was performed to elucidate the quality of life of women with hirsutism using the dermatology life quality index (DLQI). Methods: The severity of hirsutism was graded by modified Ferriman-Gallwey Score (F-G score) and correlated with quality of life by employing self-administered questionnaires of DLQI. Results: Of 40 women with hirsutism (mean DLQI score 5.55 ± 1.501), 3% demonstrated no effect, 52% small effect, and 45% moderate effect. Among domains, “symptoms and feelings” had the highest mean DLQI. Moreover, F-G score and DLQI had a weak positive but insignificant correlation. There was no significant correlation between DLQI and variables like age, marital status, occupation, and polycystic ovarian syndrome (PCOS). Conclusions: Hirsutism had a small to moderate impact on the quality of life, with symptoms and feelings as the most affected domain.
{"title":"Impact of Hirsutism on the Quality of Life: A Cross-Sectional Pilot Study from Dermatology Life Quality Index Western India","authors":"Kopal Agrawal, V. Belgaumkar, R. Chavan, N. Deshmukh","doi":"10.5812/jssc-123857","DOIUrl":"https://doi.org/10.5812/jssc-123857","url":null,"abstract":"Background: Hirsutism is defined as excess terminal hair growth over androgen-dependent areas in women. It may cause significant social and psychological stigma with a negative impact on the quality of life. However, there is a dearth of data regarding this important parameter from the Indian sub-continent. Objectives: A cross-sectional study was performed to elucidate the quality of life of women with hirsutism using the dermatology life quality index (DLQI). Methods: The severity of hirsutism was graded by modified Ferriman-Gallwey Score (F-G score) and correlated with quality of life by employing self-administered questionnaires of DLQI. Results: Of 40 women with hirsutism (mean DLQI score 5.55 ± 1.501), 3% demonstrated no effect, 52% small effect, and 45% moderate effect. Among domains, “symptoms and feelings” had the highest mean DLQI. Moreover, F-G score and DLQI had a weak positive but insignificant correlation. There was no significant correlation between DLQI and variables like age, marital status, occupation, and polycystic ovarian syndrome (PCOS). Conclusions: Hirsutism had a small to moderate impact on the quality of life, with symptoms and feelings as the most affected domain.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134279781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Diabetic foot ulcer (DFU) remains a devastating and prevalent complication of diabetes, which leads to significant morbidity, mortality, and economic implications. Outcomes of DFU management are still unsatisfactory, warranting innovations to improve them. One accessible and promising potential for treating DFU is autologous platelet-rich plasma (PRP), a blood product abundant in bioactive molecules. Platelet-rich plasma has been used in other fields of medicine to treat various conditions. Evidence Acquisition: While there is substantial research studying the use of PRP for DFU, these studies are regarded as having flaws in methodology. Hence, this systematic review aims to bridge the knowledge gap by only including randomized controlled trials (RCT). Results: After sifting through various databases, six studies were included. This review focused on specific outcomes, namely percentage of patients with healed wounds, wound size, and time to closure. Conclusions: The authors found that PRP has performed well with regards to healing DFU wounds with a high rate of healing, which leads to a shorter time to wound closure.
{"title":"Autologous Platelet-Rich Plasma in The Management of Diabetic Foot Ulcer: A Systematic Review of Randomized Controlled Trials","authors":"Dewi Fibrini, I. E. Lister, I. Rosadi","doi":"10.5812/jssc-126907","DOIUrl":"https://doi.org/10.5812/jssc-126907","url":null,"abstract":"Context: Diabetic foot ulcer (DFU) remains a devastating and prevalent complication of diabetes, which leads to significant morbidity, mortality, and economic implications. Outcomes of DFU management are still unsatisfactory, warranting innovations to improve them. One accessible and promising potential for treating DFU is autologous platelet-rich plasma (PRP), a blood product abundant in bioactive molecules. Platelet-rich plasma has been used in other fields of medicine to treat various conditions. Evidence Acquisition: While there is substantial research studying the use of PRP for DFU, these studies are regarded as having flaws in methodology. Hence, this systematic review aims to bridge the knowledge gap by only including randomized controlled trials (RCT). Results: After sifting through various databases, six studies were included. This review focused on specific outcomes, namely percentage of patients with healed wounds, wound size, and time to closure. Conclusions: The authors found that PRP has performed well with regards to healing DFU wounds with a high rate of healing, which leads to a shorter time to wound closure.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125117620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Landro, L. Martucci, M. Margulies, A. L. Douglas Price, H. Caviglia
Background: Platelet-rich plasma is an autologous blood product defined by a concentration of platelets higher than baseline. Enough evidence supports its application for the treatment of orthopedic disorders. Objectives: The aim of this study was to report the absence of infection and/or complication events related to platelet-rich plasma treatment in patients with musculoskeletal disorders of diverse etiologies. Methods: This transversal and descriptive study included a total of 513 patients, presenting either common orthopedic disorders or hemophilic synovitis/arthropathy. Peripheral whole blood was collected in the presence of anticoagulant and centrifuged. Platelet-rich fraction was separated under sterile conditions. Before injection, the affected area was sanitized and covered with sterile field drapes. Injections were performed in the procedure room under ultrasound image. No anesthesia or antibiotics were administered. Data were analyzed using Pearson’s chi-square test and Cramer’s V test. Results: Of the 923 procedures, 63.2% were intra-articular, and 36.8% were performed in soft tissues. Intra-articular injections were more common in patients with hemophilia, compared with patients without hemophilia (P < 0.001). The most commonly affected anatomical sites were: the knee, the ankle, the hip, and the elbow, with a higher prevalence of ankle and elbow disorders in patients with hemophilia, compared with patients without hemophilia (P < 0.001). Among patients with hemophilia, 13 presented HCV infection, one presented HIV infection, and three were coinfected with HCV and HIV. Twelve patients presented inhibitors. No complications were observed during blood extraction or after platelet-rich plasma injection. No infections occurred at the site of injection. Conclusions: Our platelet-rich plasma preparation and administration protocol under sterile conditions considerably reduce the chances of contamination and further complications associated with it. The occurrence of infection after intra-articular or soft tissue injection was nil in this study, even in patients with hemophilia.
{"title":"Platelet-Rich Plasma for Musculoskeletal Disorders: No Infection Reported in Daily Practice","authors":"M. Landro, L. Martucci, M. Margulies, A. L. Douglas Price, H. Caviglia","doi":"10.5812/jssc-126321","DOIUrl":"https://doi.org/10.5812/jssc-126321","url":null,"abstract":"Background: Platelet-rich plasma is an autologous blood product defined by a concentration of platelets higher than baseline. Enough evidence supports its application for the treatment of orthopedic disorders. Objectives: The aim of this study was to report the absence of infection and/or complication events related to platelet-rich plasma treatment in patients with musculoskeletal disorders of diverse etiologies. Methods: This transversal and descriptive study included a total of 513 patients, presenting either common orthopedic disorders or hemophilic synovitis/arthropathy. Peripheral whole blood was collected in the presence of anticoagulant and centrifuged. Platelet-rich fraction was separated under sterile conditions. Before injection, the affected area was sanitized and covered with sterile field drapes. Injections were performed in the procedure room under ultrasound image. No anesthesia or antibiotics were administered. Data were analyzed using Pearson’s chi-square test and Cramer’s V test. Results: Of the 923 procedures, 63.2% were intra-articular, and 36.8% were performed in soft tissues. Intra-articular injections were more common in patients with hemophilia, compared with patients without hemophilia (P < 0.001). The most commonly affected anatomical sites were: the knee, the ankle, the hip, and the elbow, with a higher prevalence of ankle and elbow disorders in patients with hemophilia, compared with patients without hemophilia (P < 0.001). Among patients with hemophilia, 13 presented HCV infection, one presented HIV infection, and three were coinfected with HCV and HIV. Twelve patients presented inhibitors. No complications were observed during blood extraction or after platelet-rich plasma injection. No infections occurred at the site of injection. Conclusions: Our platelet-rich plasma preparation and administration protocol under sterile conditions considerably reduce the chances of contamination and further complications associated with it. The occurrence of infection after intra-articular or soft tissue injection was nil in this study, even in patients with hemophilia.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129927467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Nilforoushzadeh, M. Amirkhani, Farnoosh Seirafianpour, Farzaneh Mashayekhi, P. Hejazi, A. Goodarzi
{"title":"Skin Stem Cells in Iran","authors":"M. Nilforoushzadeh, M. Amirkhani, Farnoosh Seirafianpour, Farzaneh Mashayekhi, P. Hejazi, A. Goodarzi","doi":"10.5812/jssc-126442","DOIUrl":"https://doi.org/10.5812/jssc-126442","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128204256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kachare, V. Belgaumkar, Shefali Prashant Deshpande, Chakor Vora, S. Pradhan
Introduction: Sunitinib is an inhibitor of tumor angiogenesis and has been used as the first-line drug in metastatic renal cell carcinoma (RCC). Sunitinib attracts attention due to its cutaneous toxicities, which are unusual but can range from benign self-resolving skin rash to severe systemic involvement. Herein, we report a 51-year-old male case with metastatic RCC, clear cell type. Case Presentation: Due to multifocal metastatic disease, the patient was started on tablet sunitinib 50 mg once daily (2 weeks on and 1 week off protocol) with palliative intent. On the 4th day of the second cycle, the case developed multiple reticulate palpable purpuric lesions over bilateral shins without any other constitutional or systemic symptoms, such as fever, joint pain, or abdominal pain. Skin histopathology was consistent with clinical suspicion of cutaneous small-vessel vasculitis. The potential involvement of other organs was ruled out. The lesions resolved completely within 2 weeks through symptomatic treatment with topical fluocinolone acetonide 0.01% cream and emollients. Conclusions: Sunitinib was continued uninterrupted without other organ involvement or the reappearance of lesions. Therefore, oncology care providers should always be vigilant and thoroughly evaluate any cutaneous toxicities associated with sunitinib, although it is a rare manifestation.
{"title":"Sunitinib-Induced Cutaneous Small-Vessel Vasculitis: A Rare Case Report","authors":"S. Kachare, V. Belgaumkar, Shefali Prashant Deshpande, Chakor Vora, S. Pradhan","doi":"10.5812/jssc-126370","DOIUrl":"https://doi.org/10.5812/jssc-126370","url":null,"abstract":"Introduction: Sunitinib is an inhibitor of tumor angiogenesis and has been used as the first-line drug in metastatic renal cell carcinoma (RCC). Sunitinib attracts attention due to its cutaneous toxicities, which are unusual but can range from benign self-resolving skin rash to severe systemic involvement. Herein, we report a 51-year-old male case with metastatic RCC, clear cell type. Case Presentation: Due to multifocal metastatic disease, the patient was started on tablet sunitinib 50 mg once daily (2 weeks on and 1 week off protocol) with palliative intent. On the 4th day of the second cycle, the case developed multiple reticulate palpable purpuric lesions over bilateral shins without any other constitutional or systemic symptoms, such as fever, joint pain, or abdominal pain. Skin histopathology was consistent with clinical suspicion of cutaneous small-vessel vasculitis. The potential involvement of other organs was ruled out. The lesions resolved completely within 2 weeks through symptomatic treatment with topical fluocinolone acetonide 0.01% cream and emollients. Conclusions: Sunitinib was continued uninterrupted without other organ involvement or the reappearance of lesions. Therefore, oncology care providers should always be vigilant and thoroughly evaluate any cutaneous toxicities associated with sunitinib, although it is a rare manifestation.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121648264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Avila-alvarez, Luz Marina Gomez-Vargas, Maria Camila Velez-Pelaez
Introduction: The nail bed is a fundamental structure of the nail unit. Given its close relationship with the nail plate, the distal matrix, and the hyponychium, how it interacts with these structures is still a matter of study. Case Presentation: We describe clinical cases of patients with traumatic destruction of the nail bed treated with mechanical dermabrasion in a reference center. Both clinical cases had a satisfactory response to the treatment, which supports the proposed theories about the functioning of the nail bed. Conclusions: The nail bed is a dynamic tissue that closely interacts with adjacent structures and responds to forces applied to it.
{"title":"The Nail Bed: Theories of Its Functioning and Therapeutic Mechanisms of Dermabrasion","authors":"A. Avila-alvarez, Luz Marina Gomez-Vargas, Maria Camila Velez-Pelaez","doi":"10.5812/jssc-123012","DOIUrl":"https://doi.org/10.5812/jssc-123012","url":null,"abstract":"Introduction: The nail bed is a fundamental structure of the nail unit. Given its close relationship with the nail plate, the distal matrix, and the hyponychium, how it interacts with these structures is still a matter of study. Case Presentation: We describe clinical cases of patients with traumatic destruction of the nail bed treated with mechanical dermabrasion in a reference center. Both clinical cases had a satisfactory response to the treatment, which supports the proposed theories about the functioning of the nail bed. Conclusions: The nail bed is a dynamic tissue that closely interacts with adjacent structures and responds to forces applied to it.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125818689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gautam Kumar Singh, D. Mitra, Sourabh Kumar, Nishant Raman, Pankaj Das, P. Sharma
Background: Herpes zoster (HZ) is a viral disease caused by the reactivation of the varicella-zoster virus characterized by distinctive prodromal pain followed by herpetiform vesicular eruptions. The immunocompromised states, such as old age, diabetes, human immunodeficiency virus (HIV) infection, and immunosuppressive drugs, are known predisposing factors in this regard. Objectives: The study aimed to investigate the clinic-epidemiological profile of HZ cases attending a tertiary care center. Methods: All consecutive cases of HZ reported to the dermatology outpatient department (OPD) at a tertiary care dermatological center in North India within January - June in 2019 were enrolled after obtaining informed consent and ethical clearance. The clinical profile of patients was noted on predesigned proforma. Laboratory investigations, including complete blood count, routine urine examination, renal function test, and blood sugar, were performed. The HIV antibody was tested by enzyme-linked immunosorbent assay in all cases. The data were analyzed by tabulation, mean, standard deviation on Microsoft Excel for Windows 10 operating system. Results: A total of 190 HZ cases were enrolled, that constituted 0.84% of total dermatology OPD cases of the above-mentioned duration. There were 126 male and 64 female subjects with a gender ratio of 2: 1. Out of the total number of cases, 53% were below 50 years of age, and 59% had a definite history of chickenpox. Moreover, 66 (34%) cases had comorbidities, which included 43 (22% of total cases) cases with some form of immune suppression. In addition, 11 cases were HIV positive, out of whom 2 subjects were diagnosed with HIV infection while evaluating HZ. More than 90% of cases had prodrome before eruptions. Thoracic dermatome was most commonly involved, followed by the trigeminal nerve. Corneal involvement was observed in 4 out of 11 cases of HZ ophthalmicus. The resolution period was within the range of 8 - 15 days. Moreover, 51 (27%) cases developed some complications. Postherpetic neuralgia (PHN) was present in 41 (21.5%) cases. Conclusions: The HZ constituted 0.84% of total dermatology OPD in 6 months and reflected a sizable burden in a tertiary care centre. The presence of this disease in a relatively young population or in the male gender might be due to the demographic characteristics of the dependent clientele. There was a higher incidence of PHN (21.5%) in prolonged follow-up. The involvement of thoracic dermatome as the most common segment in HZ and PHN and association with diabetes mellitus is consistent with the results of other studies.
{"title":"A Clinico-Epidemiological Study of Cases of Herpes Zoster in a Tertiary Care Hospital","authors":"Gautam Kumar Singh, D. Mitra, Sourabh Kumar, Nishant Raman, Pankaj Das, P. Sharma","doi":"10.5812/jssc.122913","DOIUrl":"https://doi.org/10.5812/jssc.122913","url":null,"abstract":"Background: Herpes zoster (HZ) is a viral disease caused by the reactivation of the varicella-zoster virus characterized by distinctive prodromal pain followed by herpetiform vesicular eruptions. The immunocompromised states, such as old age, diabetes, human immunodeficiency virus (HIV) infection, and immunosuppressive drugs, are known predisposing factors in this regard. Objectives: The study aimed to investigate the clinic-epidemiological profile of HZ cases attending a tertiary care center. Methods: All consecutive cases of HZ reported to the dermatology outpatient department (OPD) at a tertiary care dermatological center in North India within January - June in 2019 were enrolled after obtaining informed consent and ethical clearance. The clinical profile of patients was noted on predesigned proforma. Laboratory investigations, including complete blood count, routine urine examination, renal function test, and blood sugar, were performed. The HIV antibody was tested by enzyme-linked immunosorbent assay in all cases. The data were analyzed by tabulation, mean, standard deviation on Microsoft Excel for Windows 10 operating system. Results: A total of 190 HZ cases were enrolled, that constituted 0.84% of total dermatology OPD cases of the above-mentioned duration. There were 126 male and 64 female subjects with a gender ratio of 2: 1. Out of the total number of cases, 53% were below 50 years of age, and 59% had a definite history of chickenpox. Moreover, 66 (34%) cases had comorbidities, which included 43 (22% of total cases) cases with some form of immune suppression. In addition, 11 cases were HIV positive, out of whom 2 subjects were diagnosed with HIV infection while evaluating HZ. More than 90% of cases had prodrome before eruptions. Thoracic dermatome was most commonly involved, followed by the trigeminal nerve. Corneal involvement was observed in 4 out of 11 cases of HZ ophthalmicus. The resolution period was within the range of 8 - 15 days. Moreover, 51 (27%) cases developed some complications. Postherpetic neuralgia (PHN) was present in 41 (21.5%) cases. Conclusions: The HZ constituted 0.84% of total dermatology OPD in 6 months and reflected a sizable burden in a tertiary care centre. The presence of this disease in a relatively young population or in the male gender might be due to the demographic characteristics of the dependent clientele. There was a higher incidence of PHN (21.5%) in prolonged follow-up. The involvement of thoracic dermatome as the most common segment in HZ and PHN and association with diabetes mellitus is consistent with the results of other studies.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122393442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Urakov, Natalya A Urakova, Albina A. Shchemeleva, Evgeny L. Fisher
: A review of the literature shows that bruises impair the aesthetic appearance of the skin. At the same time, official medicine has no cure for urgent skin discoloration in the area of bruises. Attention is drawn to the fact that alkaline hydrogen peroxide solutions effectively decolorize blemishes and the traces of blood by local interaction under in vitro and in vivo conditions. It has been shown that the main ingredients of these solutions are water, hydrogen peroxide, and sodium hydrogen carbonate. Some products have been developed for bleaching blood stains and marks on textiles, bandages, skin, nails, and inside the skin in the area of bruises. Here, the leading medical technologies for whitening cosmetic products are reviewed.
{"title":"Bruising and Bleaching Cosmetics","authors":"A. Urakov, Natalya A Urakova, Albina A. Shchemeleva, Evgeny L. Fisher","doi":"10.5812/jssc.122867","DOIUrl":"https://doi.org/10.5812/jssc.122867","url":null,"abstract":": A review of the literature shows that bruises impair the aesthetic appearance of the skin. At the same time, official medicine has no cure for urgent skin discoloration in the area of bruises. Attention is drawn to the fact that alkaline hydrogen peroxide solutions effectively decolorize blemishes and the traces of blood by local interaction under in vitro and in vivo conditions. It has been shown that the main ingredients of these solutions are water, hydrogen peroxide, and sodium hydrogen carbonate. Some products have been developed for bleaching blood stains and marks on textiles, bandages, skin, nails, and inside the skin in the area of bruises. Here, the leading medical technologies for whitening cosmetic products are reviewed.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133551555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The quest for finding a regenerative material for periodontal defects is everlasting. Numerous resorbable, nonresorbable, synthetic, and autogenous materials have been tried and tested in this regard. The periosteum has gained popularity in this field as it has exhibited osteogenic properties. The harvest of the periosteum is hassle-free and does not cause additional surgical sites. Case Presentation: The present case report demonstrates the successful use of the periosteum as a barrier membrane in the treatment of an intrabony defect. A 25-year-old female patient reported a complaint of food lodgement and bleeding gums. Clinical and radiographic examinations suggested an intrabony defect concerning the maxillary molar. The periosteum pedicle as a barrier membrane, along with bone graft, was used to treat the defect. Conclusions: The outcome was favorable in defect filling and soft tissue thickness.
{"title":"Periosteum as Barrier Membrane: A Case Report","authors":"S. Bhatnagar, A. Chandra","doi":"10.5812/jssc.122218","DOIUrl":"https://doi.org/10.5812/jssc.122218","url":null,"abstract":"Introduction: The quest for finding a regenerative material for periodontal defects is everlasting. Numerous resorbable, nonresorbable, synthetic, and autogenous materials have been tried and tested in this regard. The periosteum has gained popularity in this field as it has exhibited osteogenic properties. The harvest of the periosteum is hassle-free and does not cause additional surgical sites. Case Presentation: The present case report demonstrates the successful use of the periosteum as a barrier membrane in the treatment of an intrabony defect. A 25-year-old female patient reported a complaint of food lodgement and bleeding gums. Clinical and radiographic examinations suggested an intrabony defect concerning the maxillary molar. The periosteum pedicle as a barrier membrane, along with bone graft, was used to treat the defect. Conclusions: The outcome was favorable in defect filling and soft tissue thickness.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126526498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Khalili, S. Shamsi meymandi, Rezvan Amiri, Mahin Aflatoonian, Shirin Alimortazavi
Background: Seborrheic keratosis is a benign epidermal proliferation, which is highly common in sun-exposed areas. This study evaluated the clinicopathological characteristics of seborrheic keratosis lesions in patients referred to the Afzalipour Hospital, Kerman, Iran. Methods: This retrospective cross-sectional study investigated ninety-nine skin biopsies of seborrheic keratosis lesions. The patients’ demographic features and the clinical and pathological features of the lesions were recorded. Then the correlation between pathological subtypes and demographics and clinical features was evaluated. Independent t-test and chi-square tests were used to assess the correlation between quantitative and qualitative data, respectively. Results: A majority of the patients were female (56.6%) in the sixth decade of their lives (33.3%). The lesions were more frequent in sun-exposed areas (65.6%). The most common pathological subtypes were acanthotic (47.5%), hyperkeratotic (27.3%), and adenoid (14.1%), and horn cyst (75.8%) and squamous eddies (5.1%) were the most and the least prevalent pathological features, respectively. Moreover, no significant correlation was noticed between pathological subtypes with the patients’ age or sun-exposed areas (P = 0.257 & P = 0.05, respectively) Conclusions: The most common pathological subtype in this study was the acanthotic type. There was no correlation between pathological subtypes and the patients’ demographic features. The most common clinicopathological correlation was associated with the sun-protected lesions.
{"title":"Clinicopathological Evaluation of Seborrheic Keratosis Lesions in Patients Referred to Afzalipour Hospital, Kerman, Iran","authors":"M. Khalili, S. Shamsi meymandi, Rezvan Amiri, Mahin Aflatoonian, Shirin Alimortazavi","doi":"10.5812/jssc.122310","DOIUrl":"https://doi.org/10.5812/jssc.122310","url":null,"abstract":"Background: Seborrheic keratosis is a benign epidermal proliferation, which is highly common in sun-exposed areas. This study evaluated the clinicopathological characteristics of seborrheic keratosis lesions in patients referred to the Afzalipour Hospital, Kerman, Iran. Methods: This retrospective cross-sectional study investigated ninety-nine skin biopsies of seborrheic keratosis lesions. The patients’ demographic features and the clinical and pathological features of the lesions were recorded. Then the correlation between pathological subtypes and demographics and clinical features was evaluated. Independent t-test and chi-square tests were used to assess the correlation between quantitative and qualitative data, respectively. Results: A majority of the patients were female (56.6%) in the sixth decade of their lives (33.3%). The lesions were more frequent in sun-exposed areas (65.6%). The most common pathological subtypes were acanthotic (47.5%), hyperkeratotic (27.3%), and adenoid (14.1%), and horn cyst (75.8%) and squamous eddies (5.1%) were the most and the least prevalent pathological features, respectively. Moreover, no significant correlation was noticed between pathological subtypes with the patients’ age or sun-exposed areas (P = 0.257 & P = 0.05, respectively) Conclusions: The most common pathological subtype in this study was the acanthotic type. There was no correlation between pathological subtypes and the patients’ demographic features. The most common clinicopathological correlation was associated with the sun-protected lesions.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122643450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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