V. Tadić, A. Zugic, S. Djordjevic, I. Zizović, I. Homšek, D. Mišić, I. Nešić
The aim of this study was to develop and validate sensitive RP-HPLC method for determination of usnic acid, as potential marker substance of the herbal product for oromucosal use being the complex mixture of plant extracts and an essential oil, including the extract of Usnea barbata. Analysis of usnic acid in the tested formulation was performed through an extraction with methanol, prior to injection on the HPLC column (Zorbax Eclipse XDB-C18 600 Bar (4.6?100 mm, 1.8 ?m)). Employed gradient procedure of the solvents (phosphoric acid (pH 2.5) and acetonitrile), at flow rate of 0.1 mL/min allowed efficient and reproducible separation of usnic acid from other compounds present in the investigated complex mixture. The established suitability, linearity, precision, accuracy and selectivity/specificity of this assay implied its applicability as a reliable examination in the stability study of the investigated multi-ingredient herbal preparation.
本研究的目的是建立并验证一种灵敏的反相高效液相色谱法(RP-HPLC)，用于测定山茱萸酸的含量。山茱萸酸是一种由植物提取物和精油组成的复杂混合物，其中包括山茱萸提取物。在高效液相色谱柱(Zorbax Eclipse XDB-C18 600 Bar (4.6?100毫米，1.8 ?m))。采用溶剂(磷酸(pH 2.5)和乙腈)的梯度法，在0.1 mL/min的流速下，可以从所研究的复杂混合物中有效地分离出usic酸和其他化合物。该方法的适宜性、线性度、精密度、准确度和选择性/特异性表明其可作为一种可靠的检测方法用于所研究的多成分中药制剂的稳定性研究。
{"title":"The RP-HPLC method for analysis of usnic acid as potential marker of herbal drugs-based formulations containing Usnea barbata","authors":"V. Tadić, A. Zugic, S. Djordjevic, I. Zizović, I. Homšek, D. Mišić, I. Nešić","doi":"10.2298/jsc201216045t","DOIUrl":"https://doi.org/10.2298/jsc201216045t","url":null,"abstract":"The aim of this study was to develop and validate sensitive RP-HPLC method for determination of usnic acid, as potential marker substance of the herbal product for oromucosal use being the complex mixture of plant extracts and an essential oil, including the extract of Usnea barbata. Analysis of usnic acid in the tested formulation was performed through an extraction with methanol, prior to injection on the HPLC column (Zorbax Eclipse XDB-C18 600 Bar (4.6?100 mm, 1.8 ?m)). Employed gradient procedure of the solvents (phosphoric acid (pH 2.5) and acetonitrile), at flow rate of 0.1 mL/min allowed efficient and reproducible separation of usnic acid from other compounds present in the investigated complex mixture. The established suitability, linearity, precision, accuracy and selectivity/specificity of this assay implied its applicability as a reliable examination in the stability study of the investigated multi-ingredient herbal preparation.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68506667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonal Bhabal, S. Shaikh, Ishita Yellapurkar, G. Pavale, M. Ramana
A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity. The in vitro anticancer activity of the synthesized compounds 4(a-h) was evaluated against four human cancer cell lines namely lung (A549), breast (MCF-7), liver (HEPG2) and prostate (PC-3) cancer. Compounds 4c, 4d, 4g and 4h exhibited good activity with GI50 <10 ?g ml-1 against all four human cancer cell lines which was comparable to standard drug Adriamycin. Additionally, antibacterial activity of synthesized compounds was estimated using resazurin microtiter assay (REMA) and compared with standard drug Ampicillin. Among the synthesized compounds, 4c, 4d, 4g and 4h showed in good antibacterial activity and all the synthesized compounds were found to be more active towards gram negative than gram positive. These promising results obtained from in vitro anticancer and antibacterial activity, inferred that the synthesized compounds are capable of being anticancer as well as antibacterial agent.
合成了一系列新型氟化1,5-苯并噻唑类衍生物，并对其体外抗癌和抗菌活性进行了表征和评价。合成的化合物4(a-h)对肺癌(A549)、乳腺癌(MCF-7)、肝癌(HEPG2)和前列腺癌(PC-3)四种人癌细胞的体外抗癌活性进行了评价。化合物4c、4d、4g和4h对四种人类癌细胞具有良好的活性，其GI50 <10 μ g ml-1，与标准药物阿霉素相当。此外，采用瑞唑脲微效价测定法(REMA)评估合成化合物的抗菌活性，并与标准药物氨苄西林进行比较。在所合成的化合物中，4c、4d、4g和4h均表现出较好的抗菌活性，且所有化合物对革兰氏阴性菌的活性均高于革兰氏阳性菌。从体外抗癌和抗菌活性的研究结果来看，所合成的化合物具有抗癌和抗菌的双重作用。
{"title":"Synthesis of novel fluorinated 1,5-benzothiazepine derivatives and their biological evaluation as anticancer and antibacterial agent","authors":"Sonal Bhabal, S. Shaikh, Ishita Yellapurkar, G. Pavale, M. Ramana","doi":"10.2298/jsc210428041b","DOIUrl":"https://doi.org/10.2298/jsc210428041b","url":null,"abstract":"A series of novel fluorinated 1,5-benzothiazepine derivatives were synthesized, characterized and evaluated for in vitro anticancer and antibacterial activity. The in vitro anticancer activity of the synthesized compounds 4(a-h) was evaluated against four human cancer cell lines namely lung (A549), breast (MCF-7), liver (HEPG2) and prostate (PC-3) cancer. Compounds 4c, 4d, 4g and 4h exhibited good activity with GI50 <10 ?g ml-1 against all four human cancer cell lines which was comparable to standard drug Adriamycin. Additionally, antibacterial activity of synthesized compounds was estimated using resazurin microtiter assay (REMA) and compared with standard drug Ampicillin. Among the synthesized compounds, 4c, 4d, 4g and 4h showed in good antibacterial activity and all the synthesized compounds were found to be more active towards gram negative than gram positive. These promising results obtained from in vitro anticancer and antibacterial activity, inferred that the synthesized compounds are capable of being anticancer as well as antibacterial agent.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"321 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68507781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Touba Eslaminejad, Yaghoub Pourshojaei, M. Naghizadeh, Hoda Eslami, Mohammad Daneshpajouh, A. Hassanzadeh
Iron homeostasis is altered in tumours in response to a perturbation in the expression of iron-dependent proteins. Therefore, iron chelators make cancerous cells more vulnerable to iron deficiency. Compounds having thiosemicarbazide scaffold with the ability to metal complex formation have the potential to act as anticancer. A series of thiosemicarbazide derivatives were designed, synthesized successfully and their cytotoxicity was then tested on some cancerous as well as laboratory normal model systems by using colorimetric assay based on WST-1 reagent. According to the cytotoxicity results, some compounds showed high toxicity effect on both the cancerous and healthy cell lines. The results of toxicity assays on U87 and A549 cell lines showed the survivability less than 50% at all concentrations higher than 10 ppm for all the synthesized compounds. The MCF-7 cell line approximately exhibited the same behaviour and had survivability less than 60%. The 3T3 in compared with HUVEC cell line showed a completely different behaviour against the synthesized compounds and had survivability more than 50%. The selectivity index was also measured and based on the study results this could be concluded that the cytotoxicity profile of the synthesized compounds on 3T3 cell line shows a significant difference, indicating a good anticancer effect for these compounds.
{"title":"Synthesis of some benzylidene thiosemicarbazide derivatives and evaluation of their cytotoxicity on U87, MCF-7, A549, 3T3 and HUVEC cell lines","authors":"Touba Eslaminejad, Yaghoub Pourshojaei, M. Naghizadeh, Hoda Eslami, Mohammad Daneshpajouh, A. Hassanzadeh","doi":"10.2298/jsc210630016e","DOIUrl":"https://doi.org/10.2298/jsc210630016e","url":null,"abstract":"Iron homeostasis is altered in tumours in response to a perturbation in the expression of iron-dependent proteins. Therefore, iron chelators make cancerous cells more vulnerable to iron deficiency. Compounds having thiosemicarbazide scaffold with the ability to metal complex formation have the potential to act as anticancer. A series of thiosemicarbazide derivatives were designed, synthesized successfully and their cytotoxicity was then tested on some cancerous as well as laboratory normal model systems by using colorimetric assay based on WST-1 reagent. According to the cytotoxicity results, some compounds showed high toxicity effect on both the cancerous and healthy cell lines. The results of toxicity assays on U87 and A549 cell lines showed the survivability less than 50% at all concentrations higher than 10 ppm for all the synthesized compounds. The MCF-7 cell line approximately exhibited the same behaviour and had survivability less than 60%. The 3T3 in compared with HUVEC cell line showed a completely different behaviour against the synthesized compounds and had survivability more than 50%. The selectivity index was also measured and based on the study results this could be concluded that the cytotoxicity profile of the synthesized compounds on 3T3 cell line shows a significant difference, indicating a good anticancer effect for these compounds.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68508032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allu Udayasri, Manchikanti Chandrasekhar, Brahmeswararao Naga, Ganesh Varanasi, D. Ramakrishna
The present work reports the synthesis of three new nitrogen-containing heteronuclear molecules (two pyrimidines and one pyrrolopyrimidine). Based on the 12 principles of green chemistry, chemical methodologies are planned and executed. Various phase transfer catalysts were examined in the crucial step to execute C-N bond formation (through SnAr mechanism), TBAI was found to be a better option than that of TBand CTAB. The one-pot synthetic methodology was optimized involving Wittig olefination and bromination to achieve a key precursor for the synthesis of a new pyrrolopyrimidine.
{"title":"Green chemical principles based regioselective functionalization of 2,4,6-trichloropyrimidine-5-carbaldehyde: Application in the synthesis of new pyrimidines and pyrrolopyrimidine","authors":"Allu Udayasri, Manchikanti Chandrasekhar, Brahmeswararao Naga, Ganesh Varanasi, D. Ramakrishna","doi":"10.2298/jsc210804063u","DOIUrl":"https://doi.org/10.2298/jsc210804063u","url":null,"abstract":"The present work reports the synthesis of three new nitrogen-containing heteronuclear molecules (two pyrimidines and one pyrrolopyrimidine). Based on the 12 principles of green chemistry, chemical methodologies are planned and executed. Various phase transfer catalysts were examined in the crucial step to execute C-N bond formation (through SnAr mechanism), TBAI was found to be a better option than that of TBand CTAB. The one-pot synthetic methodology was optimized involving Wittig olefination and bromination to achieve a key precursor for the synthesis of a new pyrrolopyrimidine.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68508984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nadia Mihoubi, S. Ferhat, R. Alouaoui, A. Ibrir, M. Nedjhioui, A. Badis
The aim of this study consists of the production of a bio-surfactant from a new bacterial strain, Marinobacter hydrocarbono clasticus SF (96.76 % simila-rity) isolated from soil contaminated by hydrocarbons in Hassi-Messaoud. (Southern Algeria) to treat liquid effluent from slaughterhouse water. The characteristics of organic matter biodegradation tests were discussed. Despite the high pollutant load and the unfavorable Physico-chemical composition of the effluent, the specific growth rate of the isolated strain after 10 days of incubation in the range of 0-30 g L-1 of NaCl was at neutral pH 7.4 and temperature of 45 ?C. The best bio-surfactant production yield was obtained after 72 h of incubation and under the optimal production conditions such as diesel as carbon source, ammonium chloride as nitrogen source, and a C/N ration of 5. The bio-surfactant produced is of glycolipid type with a low critical micellar concentration (CMC), good emulsifying power, and chemical and functional stability. Significant pollutant removal efficiency was obtained using the bacterial strain (up to 82 %) and the bio-surfactant (up to 96 %). Several anions, such as nitrates, phosphates, ammonium, and suspended solids, were measured.
{"title":"Optimization of the slaughterhouse water treatment rate by a new Marinobacter carbonoclasticus SF and its biosurfactant","authors":"Nadia Mihoubi, S. Ferhat, R. Alouaoui, A. Ibrir, M. Nedjhioui, A. Badis","doi":"10.2298/jsc211029023m","DOIUrl":"https://doi.org/10.2298/jsc211029023m","url":null,"abstract":"The aim of this study consists of the production of a bio-surfactant from a new bacterial strain, Marinobacter hydrocarbono clasticus SF (96.76 % simila-rity) isolated from soil contaminated by hydrocarbons in Hassi-Messaoud. (Southern Algeria) to treat liquid effluent from slaughterhouse water. The characteristics of organic matter biodegradation tests were discussed. Despite the high pollutant load and the unfavorable Physico-chemical composition of the effluent, the specific growth rate of the isolated strain after 10 days of incubation in the range of 0-30 g L-1 of NaCl was at neutral pH 7.4 and temperature of 45 ?C. The best bio-surfactant production yield was obtained after 72 h of incubation and under the optimal production conditions such as diesel as carbon source, ammonium chloride as nitrogen source, and a C/N ration of 5. The bio-surfactant produced is of glycolipid type with a low critical micellar concentration (CMC), good emulsifying power, and chemical and functional stability. Significant pollutant removal efficiency was obtained using the bacterial strain (up to 82 %) and the bio-surfactant (up to 96 %). Several anions, such as nitrates, phosphates, ammonium, and suspended solids, were measured.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68510506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Valerija Madzgalj, A. Petrovic, U. Čakar, V. Maras, Ivana Sofrenić, V. Tešević
This study aimed to show aromatic profile of wines produced from two autochthonous grape cultivars Krstac (K) and Zizak (Z). During the wine production two enzymatic preparations (EP) (Lallzyme cuvee blanc (CB) and Lallzyme enzymatic preparation ? (EB)) and different time of skin contact (4 and 8 h) were applied. Aromatic compounds were detected by GC/FID-MS analysis. Significantly higher content of total detected aromatic compounds compared to appropriate controls (168.54 and 161.72 mg L-1) was observed for K EB4h (176.33 mg L-1) and Z CB4h (177.29 mg L-1) wines. Skin contact and usage of EP mostly increased content of 2-phenylethyl and isoamyl alcohols. Wines from both varieties showed higher content of hexanoic and octanoic acids compared to control. It is interesting to emphasize that content of esters which are responsible for fruity aroma of wine which is important for pleasant taste (isoamyl acetate - banana, ethyl hexanoate - ripe banana, 2-phenylethyl acetate - powerful fruity rose like) were increased in all samples compared to controls. The highest grades after sensory evaluation were obtained for K EB 8h (18.0 out of 20.0) and Z CB 8h (18.2 out of 20.0).
{"title":"The influence of different enzymatic preparations and skin contact time on aromatic profile of wines produced from autochthonous grape varieties Krstac and Zizak","authors":"Valerija Madzgalj, A. Petrovic, U. Čakar, V. Maras, Ivana Sofrenić, V. Tešević","doi":"10.2298/jsc220311056m","DOIUrl":"https://doi.org/10.2298/jsc220311056m","url":null,"abstract":"This study aimed to show aromatic profile of wines produced from two autochthonous grape cultivars Krstac (K) and Zizak (Z). During the wine production two enzymatic preparations (EP) (Lallzyme cuvee blanc (CB) and Lallzyme enzymatic preparation ? (EB)) and different time of skin contact (4 and 8 h) were applied. Aromatic compounds were detected by GC/FID-MS analysis. Significantly higher content of total detected aromatic compounds compared to appropriate controls (168.54 and 161.72 mg L-1) was observed for K EB4h (176.33 mg L-1) and Z CB4h (177.29 mg L-1) wines. Skin contact and usage of EP mostly increased content of 2-phenylethyl and isoamyl alcohols. Wines from both varieties showed higher content of hexanoic and octanoic acids compared to control. It is interesting to emphasize that content of esters which are responsible for fruity aroma of wine which is important for pleasant taste (isoamyl acetate - banana, ethyl hexanoate - ripe banana, 2-phenylethyl acetate - powerful fruity rose like) were increased in all samples compared to controls. The highest grades after sensory evaluation were obtained for K EB 8h (18.0 out of 20.0) and Z CB 8h (18.2 out of 20.0).","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68513889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, cation exchange and acid activation processes were applied to determine the effects of different cationic compositions of clinoptilolite on ammonia (NH3) adsorption properties. Thermogravimetric (TG), differential thermal analysis (DTA), X-ray diffraction (XRD), X-ray fluorescence (XRF) and nitrogen adsorption techniques were used for the characterization of the clinoptilolite samples. As a result of ion exchange and acid activation, the amount, type, and location of exchangeable cations in the structure significantly affected the thermal properties as well as NH3 removal efficiency. Ammonia adsorption isotherms were obtained at 298 K up to 100 kPa volumetrically. In addition, NH3 adsorption capacities of the clinoptilolite samples within this study (3.823 to 5.372 mmol g-1) were compared with those of the other materials (1.77 to 12.2 mmol g-1) in terms of their textural and structural differences.
{"title":"Ammonia removal by natural modified clinoptilolite","authors":"Aytaç Günal, Burcu Erdoğan","doi":"10.2298/jsc211110051g","DOIUrl":"https://doi.org/10.2298/jsc211110051g","url":null,"abstract":"In this study, cation exchange and acid activation processes were applied to determine the effects of different cationic compositions of clinoptilolite on ammonia (NH3) adsorption properties. Thermogravimetric (TG), differential thermal analysis (DTA), X-ray diffraction (XRD), X-ray fluorescence (XRF) and nitrogen adsorption techniques were used for the characterization of the clinoptilolite samples. As a result of ion exchange and acid activation, the amount, type, and location of exchangeable cations in the structure significantly affected the thermal properties as well as NH3 removal efficiency. Ammonia adsorption isotherms were obtained at 298 K up to 100 kPa volumetrically. In addition, NH3 adsorption capacities of the clinoptilolite samples within this study (3.823 to 5.372 mmol g-1) were compared with those of the other materials (1.77 to 12.2 mmol g-1) in terms of their textural and structural differences.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68510485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The water hyacinth biomass was used for the synthesis of activated carbons in process of chemical activation with ZnCl2, followed by controlled pyrolysis. The applied impregnation weight ratios ZnCl2 and dry hyacinth biomass were in the range of 0.5 - 3.5. The carbonization was conducted at four different temperatures (T= 400-700?C) under an inert atmosphere. The highest yield of activated carbon was obtained for the impregnation ratio of 0.5 and carbonization temperature of 400?C. The samples were characterized using elemental analysis, adsorption-desorption isotherms of nitrogen and SEM analysis. The activated carbon obtained with an impregnation ratio 2.0 and carbonization temperature of 500?C (2.0AC500) showed the highest values of specific surface area and total pore volume of 1317 m2 g-1 and 0.697 cm3 g-1, respectively. The adsorption of glyphosate, pesticide with a strong negative environmental impact, was fast process, with equilibrium time of 120 min. The adsorption isotherms were fitted with Langmuir and Freundlich model. The Langmuir adsorption capacity of qmax=240.8 mg g-1 for 2.0AC500 classified the selected adsorbent as a very efficient one. The tested adsorption process followed the kinetics of the pseudo-second-order model.
{"title":"Synthesis of activated carbons from water hyacinth biomass and its application as adsorbents in water pollution control","authors":"Ahmad Mohammaad, M. Kijevčanin","doi":"10.2298/jsc212121006m","DOIUrl":"https://doi.org/10.2298/jsc212121006m","url":null,"abstract":"The water hyacinth biomass was used for the synthesis of activated carbons in process of chemical activation with ZnCl2, followed by controlled pyrolysis. The applied impregnation weight ratios ZnCl2 and dry hyacinth biomass were in the range of 0.5 - 3.5. The carbonization was conducted at four different temperatures (T= 400-700?C) under an inert atmosphere. The highest yield of activated carbon was obtained for the impregnation ratio of 0.5 and carbonization temperature of 400?C. The samples were characterized using elemental analysis, adsorption-desorption isotherms of nitrogen and SEM analysis. The activated carbon obtained with an impregnation ratio 2.0 and carbonization temperature of 500?C (2.0AC500) showed the highest values of specific surface area and total pore volume of 1317 m2 g-1 and 0.697 cm3 g-1, respectively. The adsorption of glyphosate, pesticide with a strong negative environmental impact, was fast process, with equilibrium time of 120 min. The adsorption isotherms were fitted with Langmuir and Freundlich model. The Langmuir adsorption capacity of qmax=240.8 mg g-1 for 2.0AC500 classified the selected adsorbent as a very efficient one. The tested adsorption process followed the kinetics of the pseudo-second-order model.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"30 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68512015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Drljaca, Ljiljana Vukic, Dajana Dragic, A. Borkovic, T. Botic, P. Dugic, Saša Papuga, Marko Solic, S. Maletić, P. Gvero, Jelena Savkovic
Wood ash is a complex mixture of inorganic and organic compounds. It is heterogeneous in composition, which can vary considerably. Ash is mainly disposed of in landfills, which poses a risk for air, soil and groundwater contamination by trace elements. In order for wood biomass ash to be used as a secondary raw material, it is necessary to perform leaching tests, to determine which microelements it contains, and which of them could be released into the environment during the ash disposal. Sequential extraction showed that in the exchangeable and carbonate fraction, the most volatile metals As, Cd, Zn and Pb are released the most from the ash of deciduous trees, while the leaching of ash from coniferous trees is significantly lower. The evaluation of risk assessment code (RAC) for the tested biomass ash samples, indicates that Pb is a high-risk leaching element due to its condensation on the ash particles. By performing TCLP (Toxicity Characteristic Leaching Procedure) and SPLP (Synthetic Precipitation Leaching Procedure) tests, it was established that the released concentrations of tested metals are below the maximum allowable concentration, given by the Regulation. The leaching tests of composites, prepared from wood ash in combination with cement, indicate that the leaching of ash is reduced to a minimum, and that all heavy metals are bound in a cement matrix, which indicates the possibility of using wood ash for construction purposes.
{"title":"Leaching of heavy metals from wood biomass ash, before and after binding in cement composite","authors":"D. Drljaca, Ljiljana Vukic, Dajana Dragic, A. Borkovic, T. Botic, P. Dugic, Saša Papuga, Marko Solic, S. Maletić, P. Gvero, Jelena Savkovic","doi":"10.2298/jsc220217054d","DOIUrl":"https://doi.org/10.2298/jsc220217054d","url":null,"abstract":"Wood ash is a complex mixture of inorganic and organic compounds. It is heterogeneous in composition, which can vary considerably. Ash is mainly disposed of in landfills, which poses a risk for air, soil and groundwater contamination by trace elements. In order for wood biomass ash to be used as a secondary raw material, it is necessary to perform leaching tests, to determine which microelements it contains, and which of them could be released into the environment during the ash disposal. Sequential extraction showed that in the exchangeable and carbonate fraction, the most volatile metals As, Cd, Zn and Pb are released the most from the ash of deciduous trees, while the leaching of ash from coniferous trees is significantly lower. The evaluation of risk assessment code (RAC) for the tested biomass ash samples, indicates that Pb is a high-risk leaching element due to its condensation on the ash particles. By performing TCLP (Toxicity Characteristic Leaching Procedure) and SPLP (Synthetic Precipitation Leaching Procedure) tests, it was established that the released concentrations of tested metals are below the maximum allowable concentration, given by the Regulation. The leaching tests of composites, prepared from wood ash in combination with cement, indicate that the leaching of ash is reduced to a minimum, and that all heavy metals are bound in a cement matrix, which indicates the possibility of using wood ash for construction purposes.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68513302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sladjana Stanisavljevic, Bojana Sreco-Zelenovic, Mirjana Popsavin, M. Rodić, V. Popsavin, V. Kojić
Four novel conformationally restricted (?)-muricatacin analogues bearing a methoxy group at the C-5 position, with an alkoxymethyl group ?s the C-7 side chain, have been synthesised and their in vitro antiproliferative activity was evaluated against a panel of seven human tumour cell lines, as well as a single normal cell line. All analogues (9-12) showed diverse antiproliferative effects against all tested human malignant cell lines, but were devoid of any significant cytotoxicity towards the normal foetal lung fibroblasts (MRC-5). A SAR study reveals that the introduction of THF ring, exchange of C-8 methylene group in the side chain of muricatacin analogues with the O-8 ether functionality, as well as the length of side chain may be beneficial for the antiproliferative effects of these lactones. All novel analogues were more potent than lead compound, (?)-muricatacin, against HL-60 cell line.
{"title":"Divergent synthesis and antitumour activity of novel conformationally constrained (−)-muricatacin analogues","authors":"Sladjana Stanisavljevic, Bojana Sreco-Zelenovic, Mirjana Popsavin, M. Rodić, V. Popsavin, V. Kojić","doi":"10.2298/jsc220613069s","DOIUrl":"https://doi.org/10.2298/jsc220613069s","url":null,"abstract":"Four novel conformationally restricted (?)-muricatacin analogues bearing a methoxy group at the C-5 position, with an alkoxymethyl group ?s the C-7 side chain, have been synthesised and their in vitro antiproliferative activity was evaluated against a panel of seven human tumour cell lines, as well as a single normal cell line. All analogues (9-12) showed diverse antiproliferative effects against all tested human malignant cell lines, but were devoid of any significant cytotoxicity towards the normal foetal lung fibroblasts (MRC-5). A SAR study reveals that the introduction of THF ring, exchange of C-8 methylene group in the side chain of muricatacin analogues with the O-8 ether functionality, as well as the length of side chain may be beneficial for the antiproliferative effects of these lactones. All novel analogues were more potent than lead compound, (?)-muricatacin, against HL-60 cell line.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68514479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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