Rahmiana Zein, Hamdhan Fathony, Putri Ramadhani, D Deswati
This study discusses kapok husk (KH) activated by HNO3 as a biosorbent for methylene blue dye and analyzes its adsorption ability. The adsorption capacity of KH is 330.161 mg g-1 with optimum conditions at pH 9, concentration 5500 mg L-1, contact time 15 minutes, and biosorbent temperature 25 ?C. The isotherm study followed the Langmuir isotherm model, as seen from the R2 value of 0.9993 and maximum adsorption capacity of 312.5 mg g-1, which indicated a monolayer layer in the adsorption process. The kinetic data show that KH followed the pseudo-second-order model. The results of the TGA analysis show that thermal stability affects the performance of biosorbents in the adsorption process. FTIR and SEM-EDS characterization results showed that electrostatic interactions, cation exchange, and pore filling regulate the methylene blue dye adsorption mechanism on the surface of the KH. The reusability of KH through adsorption-desorption cycle analysis was achieved five times. This indicates that the biosorbent can be economically feasible for real wastewater treatment based on its good reusability and simple preparation and activation.
{"title":"Facile chemically activation process of kapok husk as a low-cost biosorbent for removal methylene blue dye in aqueous solution","authors":"Rahmiana Zein, Hamdhan Fathony, Putri Ramadhani, D Deswati","doi":"10.2298/jsc230303084z","DOIUrl":"https://doi.org/10.2298/jsc230303084z","url":null,"abstract":"This study discusses kapok husk (KH) activated by HNO3 as a biosorbent for methylene blue dye and analyzes its adsorption ability. The adsorption capacity of KH is 330.161 mg g-1 with optimum conditions at pH 9, concentration 5500 mg L-1, contact time 15 minutes, and biosorbent temperature 25 ?C. The isotherm study followed the Langmuir isotherm model, as seen from the R2 value of 0.9993 and maximum adsorption capacity of 312.5 mg g-1, which indicated a monolayer layer in the adsorption process. The kinetic data show that KH followed the pseudo-second-order model. The results of the TGA analysis show that thermal stability affects the performance of biosorbents in the adsorption process. FTIR and SEM-EDS characterization results showed that electrostatic interactions, cation exchange, and pore filling regulate the methylene blue dye adsorption mechanism on the surface of the KH. The reusability of KH through adsorption-desorption cycle analysis was achieved five times. This indicates that the biosorbent can be economically feasible for real wastewater treatment based on its good reusability and simple preparation and activation.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134888981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovana Araskov, Predrag Ristic, Aleksandar Visnjevac, Andrej Milivojac, Dragana Mitic, Nenad Filipovic, Tamara Todorovic
An octahedral complex of Zn(II) with a ligand from a class of pyridine-based 1,3-selenazolyl-hydrazones was synthesized and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. The purity of the complex was confirmed by elemental analysis. Two ligands are coordinated in the neutral NNN-tridentate form forming a complex cation, while the positive charge is neutralized by [ZnCl4]2-. Complex crystallizes in monoclinic C2/c space group with the Zn atoms situated in a special position. The packing features of the novel complex were analyzed using Hirshfeld surfaces, construction of 2D pseudosymmetric plot and DFT quantum mechanical calculations and compared with the previously published sulfur-based isostere. The key difference in the structures, imposed by replacement of sulfur with selenium, were identified.
{"title":"Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone: Synthesis, structural characterization and DFT study","authors":"Jovana Araskov, Predrag Ristic, Aleksandar Visnjevac, Andrej Milivojac, Dragana Mitic, Nenad Filipovic, Tamara Todorovic","doi":"10.2298/jsc230831079a","DOIUrl":"https://doi.org/10.2298/jsc230831079a","url":null,"abstract":"An octahedral complex of Zn(II) with a ligand from a class of pyridine-based 1,3-selenazolyl-hydrazones was synthesized and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. The purity of the complex was confirmed by elemental analysis. Two ligands are coordinated in the neutral NNN-tridentate form forming a complex cation, while the positive charge is neutralized by [ZnCl4]2-. Complex crystallizes in monoclinic C2/c space group with the Zn atoms situated in a special position. The packing features of the novel complex were analyzed using Hirshfeld surfaces, construction of 2D pseudosymmetric plot and DFT quantum mechanical calculations and compared with the previously published sulfur-based isostere. The key difference in the structures, imposed by replacement of sulfur with selenium, were identified.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135008719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovana Buha-Markovic, Ana Marinkovic, J. Savić, Aleksa Krstić, A. Savic, M. Ristić
Lignite and coal waste used as feed fuels in thermal power plants (TPPs) and semi-industrial fluidized bed boiler (FBB), as well as their representative fly ashes (FAs), were examined. Fly ashes were compared employing anions and cations content in correspondent water extracts, trace elements and polycyclic aromatic hydrocarbon concentrations, as well as health risk assessments of substances known to be of concern for public health. Fluoride and sulfate contents in water extracted FAs are far below the legislation limits for waste, classifying all investigated FAs as non-hazardous. Among investigated trace elements, Cd content is the lowest, while Mn content is the highest. The highest enrichment ratios are noticed for As, Pb, Hg, Cu, V and Cr. The results indicate that total PAHs content is elevated in FA from the combustion of coal waste (AFB), with fluoranthene prevailing. The cancer risk of As and the non-cancer risk of As and Ni in some FAs surpass their respective permissible limits. The incremental lifetime cancer risk of an adult population indicates a potential PAHs risk in AFB, whereas all other fly ashes are within safe limits.
{"title":"Health risk assessment of potentially harmful substances from fly ashes generated by coal and coal waste combustion","authors":"Jovana Buha-Markovic, Ana Marinkovic, J. Savić, Aleksa Krstić, A. Savic, M. Ristić","doi":"10.2298/jsc220130048m","DOIUrl":"https://doi.org/10.2298/jsc220130048m","url":null,"abstract":"Lignite and coal waste used as feed fuels in thermal power plants (TPPs) and semi-industrial fluidized bed boiler (FBB), as well as their representative fly ashes (FAs), were examined. Fly ashes were compared employing anions and cations content in correspondent water extracts, trace elements and polycyclic aromatic hydrocarbon concentrations, as well as health risk assessments of substances known to be of concern for public health. Fluoride and sulfate contents in water extracted FAs are far below the legislation limits for waste, classifying all investigated FAs as non-hazardous. Among investigated trace elements, Cd content is the lowest, while Mn content is the highest. The highest enrichment ratios are noticed for As, Pb, Hg, Cu, V and Cr. The results indicate that total PAHs content is elevated in FA from the combustion of coal waste (AFB), with fluoranthene prevailing. The cancer risk of As and the non-cancer risk of As and Ni in some FAs surpass their respective permissible limits. The incremental lifetime cancer risk of an adult population indicates a potential PAHs risk in AFB, whereas all other fly ashes are within safe limits.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68513313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The structure, conductivity, melting points and caloric melting effects of the (Li2CO3-Na2CO3-K2CO3)eut melt/MgO nanopowder heterogeneous system with MgO concentration up to 70 vol % have been investigated. A wide variety of methods (DSC, XRD, BET, high resolution scanning electron microscope, AC impedance method, IR and Raman spectroscopy) were used to evaluate samples and research. It is revealed that at the values of effective thickness of the salt phase interlayer between MgO particles below 100 nm there is an abrupt decrease in the melting points of the salt and the normalized phase transition enthalpy of the heterogeneous system. The activation energy of the electrical conductivity rises as the values of effective thickness of the melt phase interlayer between MgO particles decreases. The study established the lack of any chemical interaction between MgO and carbonate melt at 400-600??. In situ Raman spectroscopy of the (Li2CO3-Na2CO3-K2CO3)eut melt/MgO nanopowder systems revealed the solvation of solid particles by salt-melt ions.
{"title":"Physicochemical properties of the heterogeneous system Li2CO3-Na2CO3-K2CO3/MgO","authors":"I. Zakiryanova, E. Nikolaeva, I. Korzun","doi":"10.2298/jsc230201023z","DOIUrl":"https://doi.org/10.2298/jsc230201023z","url":null,"abstract":"The structure, conductivity, melting points and caloric melting effects of the (Li2CO3-Na2CO3-K2CO3)eut melt/MgO nanopowder heterogeneous system with MgO concentration up to 70 vol % have been investigated. A wide variety of methods (DSC, XRD, BET, high resolution scanning electron microscope, AC impedance method, IR and Raman spectroscopy) were used to evaluate samples and research. It is revealed that at the values of effective thickness of the salt phase interlayer between MgO particles below 100 nm there is an abrupt decrease in the melting points of the salt and the normalized phase transition enthalpy of the heterogeneous system. The activation energy of the electrical conductivity rises as the values of effective thickness of the melt phase interlayer between MgO particles decreases. The study established the lack of any chemical interaction between MgO and carbonate melt at 400-600??. In situ Raman spectroscopy of the (Li2CO3-Na2CO3-K2CO3)eut melt/MgO nanopowder systems revealed the solvation of solid particles by salt-melt ions.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present work describes the synthesis of a new class of glycolipids with systematic variation in the linkage region as well as in the aglycon part using Cu(I) catalyzed click reaction. The linkage region between sugar and the aglycon part was diversified using amide, amido-triazole, and 5-benzoyl triazole moieties. The structural diversity of glycolipids was further amplified by incorporating several polar peptide foldamer groups such as triazole, amide, peptide, or N-aryl peptoid in the aglycon part of it. The newly designed glycolipids were derived from the amalgamation of different peptide bond mimics. This work reports the first use of N-aryl peptoid in the synthesis of glycolipids. The newly synthesized glycolipids were characterized using different spectroscopic and spectrometric analyses. The impact of the amide bond as well as the triazole ring in the linkage region on the morphology of the glycolipids was analyzed by comparing their self-assembly using SEM analysis. The geometries of the glycolipids were also optimized using density functional theory and the optimized structures were found to be minima in the potential energy surfaces.
{"title":"Click mediated synthesis of functionalized glycolipids with peptide-peptoid linkages","authors":"Anadi Singhamahapatra, Chinmayee Pattnaik, Prasad Kar, Chandra Nayak, Narayan Sahoo, Satyanarayan Sahoo","doi":"10.2298/jsc230201030s","DOIUrl":"https://doi.org/10.2298/jsc230201030s","url":null,"abstract":"The present work describes the synthesis of a new class of glycolipids with systematic variation in the linkage region as well as in the aglycon part using Cu(I) catalyzed click reaction. The linkage region between sugar and the aglycon part was diversified using amide, amido-triazole, and 5-benzoyl triazole moieties. The structural diversity of glycolipids was further amplified by incorporating several polar peptide foldamer groups such as triazole, amide, peptide, or N-aryl peptoid in the aglycon part of it. The newly designed glycolipids were derived from the amalgamation of different peptide bond mimics. This work reports the first use of N-aryl peptoid in the synthesis of glycolipids. The newly synthesized glycolipids were characterized using different spectroscopic and spectrometric analyses. The impact of the amide bond as well as the triazole ring in the linkage region on the morphology of the glycolipids was analyzed by comparing their self-assembly using SEM analysis. The geometries of the glycolipids were also optimized using density functional theory and the optimized structures were found to be minima in the potential energy surfaces.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68516850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ceren Kaya, O. Bayındır, Saruhan Saklar, O. Atakol, Hüseyin Çelikkan
The coating of aluminum nitride (AlN) powder has a great importance industrially and environmentally. AlN can be rapidly hydrolyzed to aluminum hydroxide and ammonia in the atmosphere or water media. To prevent the hydrolysis of AlN, the inorganic or organic based coatings are used frequently. First time, in this study, the phosphate esters as organophosphate coating were used for the inhibition of hydrolysis reaction of AlN in its water suspension. Phenyl phosphate showed the best inhibition against AlN hydrolysis with an easy application technique and as low as 0.005 M diluted concentration. AlN coating efficiency was proved by spectroscopic and imaging methods. It was concluded that the coating acquired the protective properties of phenyl phosphate through its water repellence.
{"title":"Preventing hydrolysis of AlN powders with organophosphate coating in aqueous media","authors":"Ceren Kaya, O. Bayındır, Saruhan Saklar, O. Atakol, Hüseyin Çelikkan","doi":"10.2298/jsc230321029k","DOIUrl":"https://doi.org/10.2298/jsc230321029k","url":null,"abstract":"The coating of aluminum nitride (AlN) powder has a great importance industrially and environmentally. AlN can be rapidly hydrolyzed to aluminum hydroxide and ammonia in the atmosphere or water media. To prevent the hydrolysis of AlN, the inorganic or organic based coatings are used frequently. First time, in this study, the phosphate esters as organophosphate coating were used for the inhibition of hydrolysis reaction of AlN in its water suspension. Phenyl phosphate showed the best inhibition against AlN hydrolysis with an easy application technique and as low as 0.005 M diluted concentration. AlN coating efficiency was proved by spectroscopic and imaging methods. It was concluded that the coating acquired the protective properties of phenyl phosphate through its water repellence.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68517213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
U. Marceta, M. Vučinić-Vasić, Jordana Ninkov, Strahinja Ilic, B. Vujic
Four monitoring campaigns of sedimentable dust were provided from two large non-sanitary landfills (Zrenjanin and Novi Sad) in Serbia during 2021. Particle size analysis by laser diffraction and inductively coupled plasma - optical emission spectrometry (ICP-OES) were carried out in order to obtain particle size distribution (PSD) and toxic elements (TEs) concentrations. The health risk assessment of the landfill employees was performed according to United States Environmental Protection Agency (US EPA) methods based on TEs concentrations. The particle size distribution results demonstrated that the majority of sedimentable dust samples mass were not concentrated neither within PM2.5 neither within PM10 fraction. Analysis revealed high concentration of TEs at both landfills: an extremely high concentration of Cr and Zn in samples from Zrenjanin landfill was detected. Health risk potential of elements was as follows for both landfills: Cr > Co > Pb > Ni > Zn > Cu. According to the results, maximal hazard index (HI) for landfill employees in Zrenjanin (1.97*10-1) and Novi Sad (1.13*10-1) showed that non-cancer risk was very low. For both landfill sites, cancer risk (CR) was highest for Cr (2.75*10-5 for Zrenjanin and 2.02*10-7 for Novi Sad), though still within the defined threshold for tolerable cancer risk.
2021年期间，从塞尔维亚的两个大型非卫生垃圾填埋场(Zrenjanin和Novi Sad)开展了四次可沉积粉尘监测活动。采用激光衍射和电感耦合等离子体-光学发射光谱(ICP-OES)分析了样品的粒径分布(PSD)和有毒元素(TEs)浓度。根据美国环境保护署(EPA)基于TEs浓度的方法对垃圾填埋场工作人员进行了健康风险评估。粒径分布结果表明，大部分可沉降尘样品质量既不集中在PM2.5范围内，也不集中在PM10范围内。分析显示，两个垃圾填埋场的TEs浓度都很高:在Zrenjanin垃圾填埋场的样品中检测到极高浓度的Cr和Zn。两个填埋场的元素健康风险潜势如下:Cr > Co > Pb > Ni > Zn > Cu。结果表明，Zrenjanin和Novi Sad的最大危害指数(HI)分别为1.97*10-1和1.13*10-1，非癌风险极低。对于这两个垃圾填埋场，CR的癌症风险(CR)最高(Zrenjanin为2.75*10-5,Novi Sad为2.02*10-7)，尽管仍在规定的可耐受癌症风险阈值之内。
{"title":"Health risk assessment of toxic elements in sedimentable dust from landfills","authors":"U. Marceta, M. Vučinić-Vasić, Jordana Ninkov, Strahinja Ilic, B. Vujic","doi":"10.2298/jsc230413032m","DOIUrl":"https://doi.org/10.2298/jsc230413032m","url":null,"abstract":"Four monitoring campaigns of sedimentable dust were provided from two large non-sanitary landfills (Zrenjanin and Novi Sad) in Serbia during 2021. Particle size analysis by laser diffraction and inductively coupled plasma - optical emission spectrometry (ICP-OES) were carried out in order to obtain particle size distribution (PSD) and toxic elements (TEs) concentrations. The health risk assessment of the landfill employees was performed according to United States Environmental Protection Agency (US EPA) methods based on TEs concentrations. The particle size distribution results demonstrated that the majority of sedimentable dust samples mass were not concentrated neither within PM2.5 neither within PM10 fraction. Analysis revealed high concentration of TEs at both landfills: an extremely high concentration of Cr and Zn in samples from Zrenjanin landfill was detected. Health risk potential of elements was as follows for both landfills: Cr > Co > Pb > Ni > Zn > Cu. According to the results, maximal hazard index (HI) for landfill employees in Zrenjanin (1.97*10-1) and Novi Sad (1.13*10-1) showed that non-cancer risk was very low. For both landfill sites, cancer risk (CR) was highest for Cr (2.75*10-5 for Zrenjanin and 2.02*10-7 for Novi Sad), though still within the defined threshold for tolerable cancer risk.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68517446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Stjepanović, A. Janković, B. Vulovic, R. Matovic, R. Saicic
The synthesis of an angular triquinane, which could serve as a suitable platform for the synthesis of several natural products (panaginsene, silphinene, senoxydene) is described. The synthesis is based on two consecutive cyclopentene annulations, where alkenes were used as latent carbonyl functionalities (via Wacker reaction), and cyclopentenone annulation was effected by aldol condensation.
{"title":"Synthetic study on the angular triquinanes","authors":"M. Stjepanović, A. Janković, B. Vulovic, R. Matovic, R. Saicic","doi":"10.2298/jsc230627046s","DOIUrl":"https://doi.org/10.2298/jsc230627046s","url":null,"abstract":"The synthesis of an angular triquinane, which could serve as a suitable platform for the synthesis of several natural products (panaginsene, silphinene, senoxydene) is described. The synthesis is based on two consecutive cyclopentene annulations, where alkenes were used as latent carbonyl functionalities (via Wacker reaction), and cyclopentenone annulation was effected by aldol condensation.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68517467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teodora Vitomirov, Božidar Čobeljić, Andrej Pevec, Dušanka D. Radanović, I. Novaković, M. Savić, K.K. Andjelković, M. Sumar-Ristovic
The condensation product of 7-acetyl-6-azaindole and Girard's T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)- N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2?6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3- N3) azide bridge binding mode has not yet occurred in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P-1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3?) ligand, and BF4? counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.
{"title":"Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity","authors":"Teodora Vitomirov, Božidar Čobeljić, Andrej Pevec, Dušanka D. Radanović, I. Novaković, M. Savić, K.K. Andjelković, M. Sumar-Ristovic","doi":"10.2298/jsc230623044v","DOIUrl":"https://doi.org/10.2298/jsc230623044v","url":null,"abstract":"The condensation product of 7-acetyl-6-azaindole and Girard's T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)- N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2?6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3- N3) azide bridge binding mode has not yet occurred in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P-1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3?) ligand, and BF4? counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68517828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danijela Nikolic, Marija Gencic, Jelena Aksic, Niko Radulovic, Dusan Dimic, Goran Kaludjerovic
Organotin(IV) compounds show great potential as antitumor metallodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterized by high bioavailability and low toxicity. In this contribution, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4- phenylbutanamide (HL1) and N-hydroxy-2-propylpentanamide (HL2), have been prepared and characterized using FTIR, 1H, 13C, and 119Sn NMR spectroscopy. Particular emphasis was put on the binding characteristics of ligands. The structures were additionally analyzed by the Density functional theory at B3LYP-D3BJ/6-311++G(d,p)(H,C,N,O)/LanL2DZ(Sn) level. The theoretical IR and NMR spectra were compared to the spectroscopic data, and it was concluded that the predicted structures described well the experimental ones. The stability of different isomers of HL1 and HL2 was assessed by the Natural Bond Orbital analysis, and the importance of intramolecular hydrogen bond was outlined. The interactions between donor atoms and Sn were investigated and correlated with changes in chemical shift and wavenumbers of characteristic vibrations.
{"title":"Diorganotin(IV) complexes with hydroxamic acids derivatives of some histone deacetylases inhibitors","authors":"Danijela Nikolic, Marija Gencic, Jelena Aksic, Niko Radulovic, Dusan Dimic, Goran Kaludjerovic","doi":"10.2298/jsc230630064n","DOIUrl":"https://doi.org/10.2298/jsc230630064n","url":null,"abstract":"Organotin(IV) compounds show great potential as antitumor metallodrugs with lower toxicity and higher antiproliferative activity. Histone deacetylases (HDAC) inhibitors are characterized by high bioavailability and low toxicity. In this contribution, the two novel octahedral organotin(IV) complexes of physiologically active hydroxamate-based ligands, N-hydroxy-4- phenylbutanamide (HL1) and N-hydroxy-2-propylpentanamide (HL2), have been prepared and characterized using FTIR, 1H, 13C, and 119Sn NMR spectroscopy. Particular emphasis was put on the binding characteristics of ligands. The structures were additionally analyzed by the Density functional theory at B3LYP-D3BJ/6-311++G(d,p)(H,C,N,O)/LanL2DZ(Sn) level. The theoretical IR and NMR spectra were compared to the spectroscopic data, and it was concluded that the predicted structures described well the experimental ones. The stability of different isomers of HL1 and HL2 was assessed by the Natural Bond Orbital analysis, and the importance of intramolecular hydrogen bond was outlined. The interactions between donor atoms and Sn were investigated and correlated with changes in chemical shift and wavenumbers of characteristic vibrations.","PeriodicalId":17489,"journal":{"name":"Journal of The Serbian Chemical Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135550598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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