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What I was thinking/what I would do differently: Biological markers and mechanisms of mental health. 我在想什么/我会采取什么不同的做法:心理健康的生物标志和机制。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-08-28 DOI: 10.1002/jts.23083
Raül Andero, Tanja Jovanovic, Murray B Stein, Arieh Y Shalev

At the 39th meeting of the International Society of Traumatic Stress Studies, four leading scientists and clinicians were invited to reflect on their careers, focusing on the biological mechanisms and markers of traumatic stress. Dr. Raul Andero has contributed to understanding how stress alters memory networks in the brain, influencing the development of novel treatments. Dr. Tanja Jovanovic has pioneered the measurement and mechanistic understanding of fear learning, bridging basic and clinical research. Dr. Murray B. Stein has scaled up clinical and lab observations to large populations, refining the field's understanding of traumatic stress. Dr. Arieh Y Shalev has shaped the definition of traumatic stress, pioneering the longitudinal investigation of stress and integrating advanced computational methods to identify individuals at risk. These panelists were asked to reflect on their initial problems, ambitions, concerns, and unexpected challenges, as well as the influence of their work, on new research trajectories. Their insights provide valuable lessons about the process and content of their work, and their pioneering efforts have significantly advanced our understanding of the biological mechanisms and markers of traumatic stress.

在国际创伤性应激反应研究学会(International Society of Traumatic Stress Studies)第 39 届会议上,四位顶尖科学家和临床医生应邀回顾了他们的职业生涯,重点探讨了创伤性应激反应的生物机制和标志物。劳尔-安德罗博士在理解压力如何改变大脑记忆网络方面做出了贡献,影响了新型治疗方法的开发。塔尼娅-约万诺维奇(Tanja Jovanovic)博士开创了恐惧学习的测量和机理理解,在基础研究和临床研究之间架起了一座桥梁。Murray B. Stein 博士将临床和实验室观察结果推广到大量人群,完善了该领域对创伤压力的理解。Arieh Y Shalev 博士塑造了创伤性压力的定义,开创了压力纵向调查的先河,并整合了先进的计算方法来识别高危人群。这些小组成员被要求反思他们最初遇到的问题、抱负、担忧和意想不到的挑战,以及他们的工作对新研究轨迹的影响。他们的见解为我们提供了有关其工作过程和内容的宝贵经验,他们的开创性努力极大地推动了我们对创伤应激的生物机制和标志物的理解。
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引用次数: 0
What I was thinking/what I would do differently: Clinical research. 我在想什么/我会采取什么不同的做法:临床研究
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-09-01 DOI: 10.1002/jts.23084
Terence M Keane, Sheila A M Rauch, Richard A Bryant

At the 2023 International Society for Traumatic Stress Studies annual meeting, a panel of three distinguished investigators and clinicians convened to reflect on their careers, their contributions to the field of traumatic stress disorders, and the lessons learned over the years. Dr. Terence M. Keane has guided the development and deployment of evidence-based care, shaping evaluation guidelines and best treatment practices for traumatic stress pathology. Dr. Sheila Rauch, a pioneer in the development of prolonged exposure therapy, has significantly contributed to the treatment of posttraumatic stress disorder (PTSD) and other traumatic stress disorders. Dr. Richard Bryant has developed targeted psychological treatments for traumatic stress and prolonged grief, adapting to the diverse needs, mechanisms, and cultural contexts of patients. These individuals' collective experiences span from the establishment of the PTSD diagnosis to the current proliferation of scientific knowledge on its epidemiology, assessment, and treatment. Their unique yet overlapping contributions have provided invaluable guidelines for the next generation of clinicians and investigators. This panel discussion offers a retrospective look at their careers and a forward-looking perspective on the future of traumatic stress treatment.

在 2023 年国际创伤性应激反应研究学会年会上,由三位杰出的研究人员和临床医生组成的专家小组回顾了他们的职业生涯、对创伤性应激障碍领域的贡献以及多年来的经验教训。特伦斯-基恩(Terence M. Keane)博士指导了循证医疗的发展和部署,制定了创伤应激病理学的评估指南和最佳治疗方法。希拉-劳奇(Sheila Rauch)博士是开发长时间暴露疗法的先驱,为治疗创伤后应激障碍(PTSD)和其他创伤应激障碍做出了重大贡献。理查德-布莱恩特(Richard Bryant)博士针对创伤应激和长期悲伤开发了有针对性的心理治疗方法,以适应患者的不同需求、机制和文化背景。从创伤后应激障碍诊断的确立到目前有关其流行病学、评估和治疗的科学知识的普及,这些人的集体经历跨越了这一时期。他们独特而又重叠的贡献为下一代临床医生和研究人员提供了宝贵的指导方针。本小组讨论回顾了他们的职业生涯,并以前瞻性的视角展望了创伤应激治疗的未来。
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引用次数: 0
Medical traumatic stress: Integrating evidence-based clinical applications from health and trauma psychology. 医疗创伤应激:整合健康心理学和创伤心理学的循证临床应用。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-07-06 DOI: 10.1002/jts.23075
Sacha McBain, Matthew J Cordova

Medical events in both childhood and adulthood, including components of the illness or injury and subsequent medical intervention, recovery, and disability, are increasingly being recognized as potentially traumatic. There has been an increased focus on scholarly work related to medical trauma and medically induced posttraumatic stress disorder (PTSD). Existing evidence suggests that trauma-focused treatment can promote both physical and psychological recovery. However, there continues to be a dearth of clinical guidance on how to (a) best identify and treat prior trauma exposure that complicates adjustment to illness and increases the risk for medically induced PTSD and (b) address medically induced PTSD while concurrently targeting health-related concerns (e.g., pain, adjustment to illness, acquired disability) that may negatively impact recovery. Originally presented as a premeeting institute at the 2023 Annual Meeting of the International Society for Traumatic Stress Studies, this paper describes the biopsychosocial impacts of medical trauma on adults and considerations for assessment and intervention in both traditional trauma and integrated care settings. This includes clinical applications, including assessment, case conceptualization, and health and rehabilitation interventions, that can promote health-related adjustment and coping within the context of trauma-focused treatment.

人们越来越认识到,儿童期和成年期的医疗事件,包括疾病或伤害的组成部分以及随后的医疗干预、恢复和残疾,都可能造成创伤。与医疗创伤和医疗诱发的创伤后应激障碍(PTSD)相关的学术研究越来越受到重视。现有证据表明,以创伤为重点的治疗可以促进身心康复。然而,在以下方面仍然缺乏临床指导:(a) 如何最好地识别和治疗先前的创伤暴露,这些创伤暴露会使疾病适应复杂化,并增加医源性创伤后应激障碍的风险;(b) 在解决医源性创伤后应激障碍的同时,如何解决可能对康复产生负面影响的健康相关问题(如疼痛、疾病适应、后天残疾)。本文最初作为国际创伤应激研究学会 2023 年年会的会前研讨会,介绍了医疗创伤对成人的生物心理社会影响,以及在传统创伤和综合护理环境中进行评估和干预的注意事项。其中包括临床应用,包括评估、病例概念化以及健康和康复干预,这些可以在以创伤为重点的治疗中促进与健康相关的调整和应对。
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引用次数: 0
Conceptualizing disparities and differences in the psychobiology of traumatic stress. 将创伤压力心理生物学中的差异和不同概念化。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI: 10.1002/jts.23081
Kelly A Correa, Vasiliki Michopoulos, Jennifer S Stevens, Nathaniel G Harnett

Understanding biological pathways that mediate trauma-related psychopathology is a major goal for traumatic stress studies. There is growing interest in studying differences in neural, physiological, and behavioral correlates of traumatic stress across demographic groups (e.g., sex/gender, race/ethnicity). However, challenges remain in how to appropriately conceptualize the source, mechanisms, and practical utility of between-group variation. The present brief conceptual review discusses ethnicity, race, and sex/gender-related variability relevant to understanding the psychobiology of traumatic stress in the context of traumatic stress studies. We discuss recent evidence related to socioenvironmental influences on ethnoracial variability in the brain and behavior relevant to traumatic stress, as well as sex/gender associations in neurophysiology that may contribute to the development of adverse posttraumatic sequelae. We further synthesize these findings by discussing intersectional influences of sex/gender- and race/ethnicity-related factors on trauma-related physical and mental health outcomes. The present review provides an important foundation for future research on disparities and individual differences in traumatic stress to move the field toward more effective assessment and treatment approaches.

了解介导创伤相关精神病理学的生物学途径是创伤应激研究的一个主要目标。人们对研究不同人口群体(如性/性别、种族/民族)在创伤应激的神经、生理和行为相关性方面的差异越来越感兴趣。然而,如何恰当地概念化群体间差异的来源、机制和实际效用仍然是一个挑战。本简要概念综述讨论了在创伤应激研究中与理解创伤应激心理生物学相关的民族、种族和性别/性别相关变异。我们讨论了社会环境对创伤应激相关的大脑和行为的人种变异性的影响,以及神经生理学中可能导致创伤后不良后遗症发展的性/性别关联的最新证据。通过讨论与性/性别和种族/人种相关的因素对创伤相关身心健康结果的交叉影响,我们进一步综合了这些发现。本综述为今后研究创伤应激的差异和个体差异奠定了重要基础,从而推动该领域朝着更有效的评估和治疗方法迈进。
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引用次数: 0
Walking the line between fidelity and flexibility: A conceptual review of personalized approaches to manualized treatments for posttraumatic stress disorder. 在忠实性和灵活性之间游刃有余:创伤后应激障碍手册化治疗个性化方法的概念回顾。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-07-02 DOI: 10.1002/jts.23073
Tara E Galovski, Reginald D V Nixon, Shannon Kehle-Forbes

The heterogeneity of the core symptoms of posttraumatic stress disorder (PTSD), high rates of comorbid mental and physical health conditions, and substantial impact of the disorder on functioning and well-being contribute to complex clinical presentations that can be challenging to treat. Despite these challenges, there are excellent manualized treatments for PTSD with significant empirical support. Although the success of frontline treatments for PTSD is evident, there remains room for improvement as indicated by suboptimal response and attrition rates. To address challenges to optimal therapy outcomes (COTOs), researchers have conducted numerous clinical trials designed to (a) enhance the core structure of treatment protocols to increase flexibility or (b) expand the protocols to address comorbid conditions that inhibit recovery. However, it is implausible to ever conduct the number of enhancement and expansion clinical trials necessary to test manual modifications for the universe of possible COTOs. This conceptual review describes the concept of a personalized model of therapy that leverages a case formulation approach to implementing an evidence-based treatment for PTSD. This personalized approach provides guidance for the clinician in assessing the patient's COTOs, monitoring them throughout treatment, and relying on the patient's idiosyncratic data to inform treatment decisions, including how and when to diverge from treatment when clinically indicated and ensuring a clear path to return to trauma-focused work when the COTO is stabilized. This personalized, case formulation approach to treating PTSD provides guidance for adopting a more flexible approach to treating clinically complex patients while ensuring fidelity to the protocol.

创伤后应激障碍(PTSD)核心症状的异质性、精神和身体健康状况的高并发率以及该障碍对功能和福祉的巨大影响,导致临床表现复杂,治疗起来极具挑战性。尽管存在这些挑战,但创伤后应激障碍仍有很好的手册化治疗方法,并得到了大量的经验支持。尽管创伤后应激障碍的一线治疗取得了明显的成功,但仍有改进的余地,这体现在不理想的反应率和减员率上。为了应对最佳治疗结果(CTOs)所面临的挑战,研究人员开展了大量临床试验,旨在(a)加强治疗方案的核心结构,以提高灵活性;或(b)扩展治疗方案,以解决抑制康复的合并症。然而,要进行大量必要的增强和扩展临床试验,以测试针对所有可能的 COTO 进行的手动修改,是不可能的。本概念性综述描述了个性化治疗模式的概念,该模式利用病例制定法来实施创伤后应激障碍的循证治疗。这种个性化方法为临床医生评估患者的 COTO、在整个治疗过程中对其进行监控以及依靠患者的特异性数据为治疗决策提供指导,包括在有临床指征时如何以及何时偏离治疗,并确保在 COTO 稳定后有明确的路径返回以创伤为重点的工作。这种治疗创伤后应激障碍的个性化病例制定方法为采用更灵活的方法治疗临床复杂的患者提供了指导,同时确保忠实于治疗方案。
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引用次数: 0
Engaging the child-parent relationship to treat early trauma: The challenge and promise of scaling with fidelity. 利用儿童与家长的关系治疗早期创伤:忠实扩展的挑战与希望。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI: 10.1002/jts.23077
Alicia F Lieberman, Chandra Ghosh Ippen

There is an urgent imperative to scale up access to effective, family-focused mental health services for trauma-exposed infants, toddlers, and preschoolers, who represent the most vulnerable and most underserved sector of the clinical child population. This article describes the process of scaling child-parent psychotherapy, an evidence-based treatment currently used in 39 U.S. states and six countries, as an example of the promise and challenge of large-scale implementation of relationship-based treatments.

婴幼儿和学龄前儿童是临床儿童群体中最脆弱、最得不到充分服务的群体,因此当务之急是扩大为遭受创伤的婴幼儿和学龄前儿童提供有效的、以家庭为中心的心理健康服务。本文介绍了儿童-家长心理疗法的推广过程,这是一种基于证据的治疗方法,目前在美国 39 个州和 6 个国家使用,以此为例说明大规模实施基于关系的治疗方法的前景和挑战。
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引用次数: 0
What I was thinking/what I would do differently: Technology-enabled traumatic stress support. 我在想什么/我会采取什么不同的做法:通过技术提供创伤应激支持。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.1002/jts.23095
Brian P Marx, Barabara O Rothbaum, Eric Vermetten

At the 39th meeting of the International Society of Traumatic Stress Studies, three leading researchers and clinicians in technology-enabled traumatic stress support were invited to reflect on their careers and contributions to the field. Dr. Brian P. Marx has led the development of large-scale technologies to screen, assess, and treat traumatic stress pathology across diverse etiologies and needs. Dr. Barbara O. Rothbaum, a pioneer in the development of virtual reality for exposure therapy, has demonstrated the efficacy and scalability of digital treatment for traumatic stress. Retired Col. Dr. Eric Vermetten has worked extensively on the intersection of basic mechanisms, novel psychological and biological treatment, and technology for scalable assessment and treatment, primarily in military and mass casualty contexts. The panelists were asked to reflect on their initial ambitions, concerns, unexpected challenges, and the influence of their work on new research trajectories. Their insights provide valuable lessons about the process and content of their work, and their pioneering efforts have significantly advanced the field of technology-enabled traumatic stress support.

在国际创伤性应激反应研究学会(International Society of Traumatic Stress Studies)第 39 届会议上,三位创伤性应激反应技术支持领域的顶尖研究人员和临床医生应邀回顾了他们的职业生涯和对该领域的贡献。Brian P. Marx 博士领导开发了大规模技术,用于筛查、评估和治疗不同病因和需求的创伤应激病理学。Barbara O. Rothbaum 博士是开发用于暴露疗法的虚拟现实技术的先驱,她证明了创伤压力数字化治疗的有效性和可扩展性。退役上校 Eric Vermetten 博士在基本机制、新型心理和生物治疗以及可扩展评估和治疗技术的交叉领域开展了广泛的工作,主要是在军事和重大人员伤亡方面。小组成员被要求反思他们最初的抱负、关注的问题、意想不到的挑战以及他们的工作对新研究轨迹的影响。他们的见解为他们的工作过程和内容提供了宝贵的经验,他们的开拓性努力极大地推动了创伤应激支持技术领域的发展。
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引用次数: 0
Tipping the scales for global mental health: A summary of the Presidential Panel at the 39th Annual Meeting of the International Society for Traumatic Stress Studies. 全球心理健康的天平:国际创伤压力研究学会第 39 届年会主席小组讨论摘要。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI: 10.1002/jts.23085
Marit Sijbrandij, Judith K Bass, Kenneth Carswell, Syed Usman Hamdani, Eirini Karyotaki

In the past decade, there has been an increasing focus within scientific research on how to assist people affected by the negative consequences of trauma and crises around the globe. As many countries struggle with a lack of resources to deliver mental health interventions, scalable strategies have been developed to help more people in need. These scalable strategies were the theme of the 39th annual meeting of the International Society for Traumatic Stress Studies (ISTSS). The presidential panel, chaired by Marit Sijbrandij during her ISTSS presidency, brought together a group of experts in the field of scalable interventions: Kenneth Carswell, Syed Usman Hamdani, Judy Bass, and Eirini Karyotaki. The panel highlighted the current state of the evidence on scalable interventions for adults and children and outlined important next steps for research and implementation. These recommendations include further improving the availability of, and evidence for, scalable interventions through increased training and sustained funding; conducting more studies in underrepresented samples, such as children and adolescents; and promoting open access availability of research findings worldwide. In this paper, we provide an overview of the topics discussed in the panel as well as the key takeaways.

在过去十年中,科学研究越来越关注如何帮助全球受创伤和危机负面影响的人们。由于许多国家都在为缺乏资源来提供心理健康干预措施而苦苦挣扎,因此,人们制定了可扩展的战略来帮助更多需要帮助的人。这些可扩展战略是国际创伤压力研究学会(ISTSS)第 39 届年会的主题。由玛丽特-西布兰迪(Marit Sijbrandij)在担任 ISTSS 主席期间主持的主席小组会议汇集了可扩展干预领域的众多专家:他们是:肯尼斯-卡斯韦尔(Kenneth Carswell)、赛义德-乌斯曼-哈姆达尼(Syed Usman Hamdani)、朱迪-巴斯(Judy Bass)和埃里妮-卡里奥塔基(Eirini Karyotaki)。专家小组强调了针对成人和儿童的可扩展干预措施的证据现状,并概述了下一步研究和实施的重要步骤。这些建议包括:通过加强培训和持续资助,进一步改善可扩展干预措施的可用性和证据;在儿童和青少年等代表性不足的样本中开展更多研究;以及促进研究成果在全球范围内的开放获取。在本文中,我们将概述小组讨论的主题以及主要收获。
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引用次数: 0
The three axioms of resilience. 复原力的三个公理。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-06-05 DOI: 10.1002/jts.23071
George A Bonanno, Maren Westphal

This article summarizes the growing literature on resilience in the face of aversive and potentially traumatic events (PTEs) in three basic axioms: (a) resilience is a common outcome, 2) there are no "key" traits to resilience (resilience is not a type), and (c) resilient outcomes occur through flexible self-regulation. The first axiom highlights the limitation of a traditional, binary view of trauma in terms of the presence-absence of posttraumatic stress disorder, emphasizing instead the heterogeneity of trauma outcomes. Four prototypical trajectories are reviewed: chronic symptoms; delayed symptoms; recovery; and the most common trajectory, resilience. The second axiom reviews the paradoxical inability of known correlates of resilience to adequately predict resilient outcomes. Resilience is instead described as a multifaceted phenomenon with no singular set of key traits, as various factors contribute to resilient outcomes in complex ways. The third axiom provides an explanation of how resilience can emerge from this complex array by introducing the concept of flexible self-regulation. The flexibility mindset is described as providing the motivation for flexible responding. The flexibility sequence is described as explaining the mechanisms underlying flexibility in terms of three serial stages: context sensitivity, strategy repertoire, and feedback adjustment. The final section briefly considers clinical implications.

面对厌恶性和潜在创伤事件(PTEs),抗逆力是一种常见的结果;2)抗逆力没有 "关键 "特征(抗逆力不是一种类型);3)抗逆力结果是通过灵活的自我调节产生的。第一条公理强调了以创伤后应激障碍的存在与否来看待创伤的传统二元观点的局限性,转而强调了创伤结果的异质性。本文回顾了四种原型轨迹:慢性症状、延迟症状、康复以及最常见的恢复力轨迹。第二条公理回顾了抗逆力的已知相关因素无法充分预测抗逆力结果这一矛盾现象。抗逆力被描述为一种多方面的现象,没有一套单一的关键特征,因为各种因素以复杂的方式促成了抗逆力的结果。第三条公理通过引入灵活自我调节的概念,解释了抗逆力如何从这一系列复杂的因素中产生。灵活心态被描述为灵活应对的动力。灵活性序列被描述为从三个序列阶段来解释灵活性的内在机制:情境敏感性、策略再现和反馈调整。最后一节简要探讨了其临床意义。
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引用次数: 0
A functional approach to defining and repairing moral injury: Evidence, change agents, clinical strategies, and lessons learned. 界定和修复道德伤害的功能性方法:证据、变革推动者、临床策略和经验教训。
IF 2.4 3区 医学 Q2 PSYCHIATRY Pub Date : 2024-10-01 Epub Date: 2024-06-04 DOI: 10.1002/jts.23063
Brett T Litz

This is a conceptual overview of a premeeting institute (PMI) I presented at the 39th International Society for Traumatic Stress Studies (ISTSS) annual meeting in November 2023 entitled, "A Functional Approach to Repairing Moral Injury and Traumatic Loss in Context: Evidence, Change Agents, Clinical Strategies, and Lessons Learned." This paper was invited by the co-chairs of the Scientific Program Committee, Isaac Galatzer-Levy and Katharina Schultebraucks. I first describe the aims of the PMI and then summarize the foundational assumptions that led me to expand adaptive disclosure and create adaptive disclosure-enhanced (AD-E). The foundational assumptions are that (a) moral injury is a unique measurable potential clinical problem, (b) moral injury damages the sustaining building blocks to personal and collective humanity, and (c) repairing moral injury requires corrective humanizing and virtuous experiences and connections. I then provide an overview of AD-E and describe two new change agents- loving-kindness meditation and letter writing-that augment the original AD in service of promoting corrective experiences in the social world that are valued, valuing, and promote the experience of belonging.

这是我在 2023 年 11 月举行的第 39 届国际创伤应激研究学会(ISTSS)年会上所做的会前研 究(PMI)的概念性概述,题为 "修复道德伤害和创伤损失的功能性方法":证据、变革者、临床策略和经验教训"。本文应科学项目委员会联合主席艾萨克-加拉策-列维(Isaac Galatzer-Levy)和卡塔琳娜-舒尔特布劳克斯(Katharina Schultebraucks)的邀请而作。我首先介绍了 PMI 的目的,然后总结了促使我扩大适应性披露并创建适应性披露增强型(AD-E)的基本假设。这些基本假设是:(a)道德伤害是一个独特的、可测量的、潜在的临床问题;(b)道德伤害损害了个人和集体人性的基石;(c)修复道德伤害需要纠正人性化和良性的体验和联系。然后,我概述了 AD-E,并介绍了两种新的改变媒介--慈爱冥想和写信--它们增强了原有的 AD,以促进社会世界中的矫正体验,这些体验是有价值的、有价值的,并能促进归属感体验。
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引用次数: 0
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Journal of traumatic stress
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