Pub Date : 2025-01-31DOI: 10.1016/j.jve.2025.100585
Mobin Ibne Mokbul , Shuvajit Saha , Samiha Nahar Tuli , Fatema Binte Nur , A.M. Khairul Islam , Tariful Islam , Shirsho Shreyan , Alok Bijoy Bhadra , Golam Dastageer Prince , Irfath Sharmin Eva , Mustari Nailah Tabassum , Ferdous Wahid , Md Irfan Bin Kayes , Nazim Hassan Ziad , Mohammad Delwer Hossain Hawlader
The emergence of the Nipah virus (NiV) poses a significant global health threat, particularly in South-East Asian countries. This cross-sectional nationwide study is a pioneer in assessing knowledge levels of NiV outbreak among the general population in Bangladesh. It was conducted among the general population of Bangladesh from 15th January to 10th February 2024. A conveniently selected sample of individuals participated in the assessment of their knowledge about NiV. A semi-structured questionnaire was used as the data collection tool. After data curation, a total of 2121 responses that met the inclusion criteria were retained for analysis. Among 2121 participants, 69.38 % were aware of NiV. Overall, 62 % demonstrated good knowledge of the virus. The main sources of information were social media (29.9 %), television (25.41 %), educational institutions (18.95 %), newspapers (13.65 %), friends (6.39 %), and workplaces (5.91 %). Multivariate logistic regression analysis showed that participants aged 31–40 years had lower odds of poor knowledge (OR = 0.57, 95 % CI: 0.39–0.82, p < 0.01) compared to those aged 21–30. Females had higher odds of poor knowledge (OR = 1.38, 95 % CI: 1.05–1.81, p = 0.02) than males. Lower education levels were associated with higher odds of poor knowledge. Moreover, non-healthcare workers also had higher odds of poor knowledge compared to healthcare workers. There were regional differences, with varying odds in Rangpur (OR = 0.43, 95 % CI: 0.26–0.70, p < 0.01), Khulna (OR = 1.70, 95 % CI: 1.10–2.61, p = 0.01), and Mymensingh (OR = 2.77, 95 % CI: 1.70–4.53, p < 0.01) compared to Dhaka. The current study underscores the importance of evidence-based educational strategies, and may guide government and policymakers to design future targeted interventions to enhance public health literacy and mitigate the spread of NiV in Bangladesh as well as in its neighbouring countries.
{"title":"Assessment of the general population knowledge about the emergence of Nipah virus outbreak in Bangladesh: A nationwide cross-sectional study","authors":"Mobin Ibne Mokbul , Shuvajit Saha , Samiha Nahar Tuli , Fatema Binte Nur , A.M. Khairul Islam , Tariful Islam , Shirsho Shreyan , Alok Bijoy Bhadra , Golam Dastageer Prince , Irfath Sharmin Eva , Mustari Nailah Tabassum , Ferdous Wahid , Md Irfan Bin Kayes , Nazim Hassan Ziad , Mohammad Delwer Hossain Hawlader","doi":"10.1016/j.jve.2025.100585","DOIUrl":"10.1016/j.jve.2025.100585","url":null,"abstract":"<div><div>The emergence of the Nipah virus (NiV) poses a significant global health threat, particularly in South-East Asian countries. This cross-sectional nationwide study is a pioneer in assessing knowledge levels of NiV outbreak among the general population in Bangladesh. It was conducted among the general population of Bangladesh from 15th January to 10th February 2024. A conveniently selected sample of individuals participated in the assessment of their knowledge about NiV. A semi-structured questionnaire was used as the data collection tool. After data curation, a total of 2121 responses that met the inclusion criteria were retained for analysis. Among 2121 participants, 69.38 % were aware of NiV. Overall, 62 % demonstrated good knowledge of the virus. The main sources of information were social media (29.9 %), television (25.41 %), educational institutions (18.95 %), newspapers (13.65 %), friends (6.39 %), and workplaces (5.91 %). Multivariate logistic regression analysis showed that participants aged 31–40 years had lower odds of poor knowledge (OR = 0.57, 95 % CI: 0.39–0.82, p < 0.01) compared to those aged 21–30. Females had higher odds of poor knowledge (OR = 1.38, 95 % CI: 1.05–1.81, p = 0.02) than males. Lower education levels were associated with higher odds of poor knowledge. Moreover, non-healthcare workers also had higher odds of poor knowledge compared to healthcare workers. There were regional differences, with varying odds in Rangpur (OR = 0.43, 95 % CI: 0.26–0.70, p < 0.01), Khulna (OR = 1.70, 95 % CI: 1.10–2.61, p = 0.01), and Mymensingh (OR = 2.77, 95 % CI: 1.70–4.53, p < 0.01) compared to Dhaka. The current study underscores the importance of evidence-based educational strategies, and may guide government and policymakers to design future targeted interventions to enhance public health literacy and mitigate the spread of NiV in Bangladesh as well as in its neighbouring countries.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"11 1","pages":"Article 100585"},"PeriodicalIF":3.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143146405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The hepatitis A virus (HAV) and rotavirus are mainly transmitted through fecal-oral and person-to-person contact, and cause severe gastrointestinal complications and liver disease. This work used reverse vaccinology and immunoinformatic methods to create a novel bivalent vaccine against rotavirus and HAV. The amino acid sequences of HAV-rotavirus proteins (VP1 and VP8∗) were retrieved from the GenBank database. Various computational approaches were employed to predict highly conserved regions and the most immunogenic B-cell and T-cell epitopes of VP8 and VP1 of rotavirus and HAV proteins in both humans and BALB/c. Moreover, the predicted fusion protein was analyzed regarding primary and secondary structures and homology validation. In this study, we used two highly conserved peptide sequences of VP8 and VP1 of rotavirus and HAV that induce T and B cell immunogenicity. According to T-cell epitope prediction, this area comprises 2713 antigenic peptides for HLA class II and 30 HLA class I antigenic peptides, both of which are virtually entirely conserved in the Iranian population. In this study, validation as well as analysis of the secondary and three-dimensional structure of the VP8∗-rotavirus + AAY + HAV-VP1 fusion protein, with the aim of designing a multi-epitope vaccine with different receptors. TLR 3, 4 high immunogenic binding ability with immunological properties and interaction between multi-epitope target and TLR were predicted, and it is expected that the target fusion protein has stable antigenic potency and compatible half-life. The above is suggested as a universal vaccination program.
{"title":"Development of a novel bivalent vaccine candidate against hepatitis A virus and rotavirus using reverse vaccinology and immunoinformatics","authors":"Hassan Yarmohammadi , Abbas Akhavan Sepahi , Mojtaba Hamidi-fard , Mohammadreza Aghasadeghi , Golnaz Bahramali","doi":"10.1016/j.jve.2024.100578","DOIUrl":"10.1016/j.jve.2024.100578","url":null,"abstract":"<div><div>The hepatitis A virus (HAV) and rotavirus are mainly transmitted through fecal-oral and person-to-person contact, and cause severe gastrointestinal complications and liver disease. This work used reverse vaccinology and immunoinformatic methods to create a novel bivalent vaccine against rotavirus and HAV. The amino acid sequences of HAV-rotavirus proteins (VP1 and VP8∗) were retrieved from the GenBank database. Various computational approaches were employed to predict highly conserved regions and the most immunogenic B-cell and T-cell epitopes of VP8 and VP1 of rotavirus and HAV proteins in both humans and BALB/c. Moreover, the predicted fusion protein was analyzed regarding primary and secondary structures and homology validation. In this study, we used two highly conserved peptide sequences of VP8 and VP1 of rotavirus and HAV that induce T and B cell immunogenicity. According to T-cell epitope prediction, this area comprises 2713 antigenic peptides for HLA class II and 30 HLA class I antigenic peptides, both of which are virtually entirely conserved in the Iranian population. In this study, validation as well as analysis of the secondary and three-dimensional structure of the VP8∗-rotavirus + AAY + HAV-VP1 fusion protein, with the aim of designing a multi-epitope vaccine with different receptors. TLR 3, 4 high immunogenic binding ability with immunological properties and interaction between multi-epitope target and TLR were predicted, and it is expected that the target fusion protein has stable antigenic potency and compatible half-life. The above is suggested as a universal vaccination program.</div></div>","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"11 1","pages":"Article 100578"},"PeriodicalIF":3.5,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100434
M. Nühn, N. Sabet, K. Van Abeelen, P. Schipper, A. Basson, A. Wensing, L. De Witte, M. Papathanasopoulos, M. Nijhuis, J. Symons, Justine T. Blonk, Nanouk Zuidmeer
{"title":"7.5 – 00009 Postmortem analyses of the central nervous system in individuals with HIV demonstrate that infection of microglia contributes to inflammatory pathways despite viral suppression","authors":"M. Nühn, N. Sabet, K. Van Abeelen, P. Schipper, A. Basson, A. Wensing, L. De Witte, M. Papathanasopoulos, M. Nijhuis, J. Symons, Justine T. Blonk, Nanouk Zuidmeer","doi":"10.1016/j.jve.2024.100434","DOIUrl":"10.1016/j.jve.2024.100434","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 27-28"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100447
D. Reeves, M. Litchford, C. Fish, A. Farrell-Sherman, N. Ahmed, M. Poindexter, N. Cassidy, J. Neary, D. Wamalwa, A. Langat, D. Chebet, H. Moraa, J. Slyker, S. Benki-Nugent, L. Cohn, J. Schiffer, J. Overbaugh, G. John-Stewart, D. Lehman
{"title":"ST2.2 – 00065 Models and correlates of intact and defective HIV DNA decay in Kenyan children over 8 years of ART","authors":"D. Reeves, M. Litchford, C. Fish, A. Farrell-Sherman, N. Ahmed, M. Poindexter, N. Cassidy, J. Neary, D. Wamalwa, A. Langat, D. Chebet, H. Moraa, J. Slyker, S. Benki-Nugent, L. Cohn, J. Schiffer, J. Overbaugh, G. John-Stewart, D. Lehman","doi":"10.1016/j.jve.2024.100447","DOIUrl":"10.1016/j.jve.2024.100447","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 36"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100476
R. Matus Nicodemos, D. Ambrozak, D. Douek, R. Koup
{"title":"PP2.6 – 00048 The HIV reservoir can be established in either quiescent or senescent CD4 T cells","authors":"R. Matus Nicodemos, D. Ambrozak, D. Douek, R. Koup","doi":"10.1016/j.jve.2024.100476","DOIUrl":"10.1016/j.jve.2024.100476","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 56-57"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100481
M. Yang, U. Mbonye, S. Wu, C.M. Chang, J. Karn
{"title":"PP2.11 – 00011 The cellular factors BRD4 and HSF1 are critical initiators of P-TEFbdependent HIV-1 latency reversal in primary T cells","authors":"M. Yang, U. Mbonye, S. Wu, C.M. Chang, J. Karn","doi":"10.1016/j.jve.2024.100481","DOIUrl":"10.1016/j.jve.2024.100481","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Page 59"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100452
D. Gludish, J. Choi
{"title":"PP1.3 – 00155 Robust proviral transcription but complete restriction of HIV virion production in fetal liver macrophages: a new model for viral persistence in tissue-resident macrophages","authors":"D. Gludish, J. Choi","doi":"10.1016/j.jve.2024.100452","DOIUrl":"10.1016/j.jve.2024.100452","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 40-41"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100492
S. Rutsaert, J. De Clercq, L. Vandekerckhove, S. Gerlo
{"title":"PP4.5 – 00144 Unveiling Cellular Phenotypes and Transcriptional Dynamics in Early Treated Acute HIV Infection","authors":"S. Rutsaert, J. De Clercq, L. Vandekerckhove, S. Gerlo","doi":"10.1016/j.jve.2024.100492","DOIUrl":"10.1016/j.jve.2024.100492","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 66-67"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jve.2024.100453
K.L. Walker, Y. Thomas, S. Arif, S. Samer, C. Rische, R. Krier, J.A. O’Sullivan, R.L. Redondo, A.M. Carias, T. Russo, M. McRaven, E. Allen, C.T. Thuruthiyil, F. Engleman, E. Martinelli, F. Villinger, B. Bochner, T.J. Hope
{"title":"PP1.4 – 00138 SIV and HIV Infection of Mast Cells","authors":"K.L. Walker, Y. Thomas, S. Arif, S. Samer, C. Rische, R. Krier, J.A. O’Sullivan, R.L. Redondo, A.M. Carias, T. Russo, M. McRaven, E. Allen, C.T. Thuruthiyil, F. Engleman, E. Martinelli, F. Villinger, B. Bochner, T.J. Hope","doi":"10.1016/j.jve.2024.100453","DOIUrl":"10.1016/j.jve.2024.100453","url":null,"abstract":"","PeriodicalId":17552,"journal":{"name":"Journal of Virus Eradication","volume":"10 ","pages":"Pages 41-42"},"PeriodicalIF":3.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143181386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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