This study aims to describe the ultrasound characteristics of keratoacanthoma (KA), providing valuable insights for non-invasive diagnosis and differentiation from well-differentiated cutaneous squamous cell carcinoma (wcSCC).
Methods
Ultrasound characteristics of 16 KA and 13 wcSCC conformed by surgical pathology were retrospective analyzed.
Results
KA patients were younger (mean age 63.13 years) compared with wcSCC patients (mean age 76.23 years). Ultrasound characteristics revealed that KA lesions were generally smaller, more frequently domed-shaped (87.50 vs 38.46%), exophytic (93.75 vs 30.77%), and well-defined (93.75 vs 53.85%) compared with wcSCC. Both lesion types predominantly showed hypoechoic internal echoes and inhomogeneous echotexture. The prevalence of hyperechoic superficial area was notably high in both groups (93.75 vs 84.62%), precluding the reliable use of this feature as a discriminatory marker between these two distinct neoplastic entities. KA lesions were mostly confined to the epidermis and superficial dermis (87.50%), while wcSCC cases frequently infiltrated into the subcutaneous fat layer (84.62%). Color Doppler imaging demonstrated higher vascularity in wcSCC lesions, with 61.5% showing Grade 3 flow, compared with KA lesions, where 62.5% exhibited Grade 2 flow.
Conclusions
High-frequency ultrasound reveals distinct ultrasound characteristics differentiating KA from wcSCC, offering a promising non-invasive tool for preliminary diagnosis and treatment planning.
目的：本研究旨在描述角化棘皮瘤（KA）的超声特征，为无创诊断和与分化良好的皮肤鳞状细胞癌（wcSCC）的鉴别提供有价值的见解：方法：回顾性分析了 16 例 KA 和 13 例经手术病理确诊的 wcSCC 的超声特征：结果：与 wcSCC 患者（平均年龄 76.23 岁）相比，KA 患者更年轻（平均年龄 63.13 岁）。超声特征显示，与 wcSCC 相比，KA 病变一般较小，多呈圆顶形（87.50 vs 38.46%）、外生性（93.75 vs 30.77%）和界限清楚（93.75 vs 53.85%）。两种病变类型都主要表现为内部回声不足和回声纹理不均匀。高回声表层区域在两组中的发生率都很高（93.75% vs 84.62%），因此无法将这一特征作为区分这两种不同肿瘤实体的可靠标志。KA 病变大多局限于表皮和真皮浅层（87.50%），而 wcSCC 病例则经常浸润到皮下脂肪层（84.62%）。彩色多普勒成像显示，wcSCC 病变中的血管密度更高，61.5% 显示 3 级血流，而 KA 病变中 62.5% 显示 2 级血流：结论：高频超声显示了区分 KA 和 wcSCC 的独特超声特征，为初步诊断和治疗计划提供了一种前景广阔的无创工具。
{"title":"Ultrasound Characteristics of Keratoacanthoma","authors":"Yan-xuan Chen MD, Jian-feng Liang MD, Ling-li Xiao MD, De-rui Zhan MD, Jing Wang MD","doi":"10.1002/jum.16622","DOIUrl":"10.1002/jum.16622","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to describe the ultrasound characteristics of keratoacanthoma (KA), providing valuable insights for non-invasive diagnosis and differentiation from well-differentiated cutaneous squamous cell carcinoma (wcSCC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ultrasound characteristics of 16 KA and 13 wcSCC conformed by surgical pathology were retrospective analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>KA patients were younger (mean age 63.13 years) compared with wcSCC patients (mean age 76.23 years). Ultrasound characteristics revealed that KA lesions were generally smaller, more frequently domed-shaped (87.50 vs 38.46%), exophytic (93.75 vs 30.77%), and well-defined (93.75 vs 53.85%) compared with wcSCC. Both lesion types predominantly showed hypoechoic internal echoes and inhomogeneous echotexture. The prevalence of hyperechoic superficial area was notably high in both groups (93.75 vs 84.62%), precluding the reliable use of this feature as a discriminatory marker between these two distinct neoplastic entities. KA lesions were mostly confined to the epidermis and superficial dermis (87.50%), while wcSCC cases frequently infiltrated into the subcutaneous fat layer (84.62%). Color Doppler imaging demonstrated higher vascularity in wcSCC lesions, with 61.5% showing Grade 3 flow, compared with KA lesions, where 62.5% exhibited Grade 2 flow.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>High-frequency ultrasound reveals distinct ultrasound characteristics differentiating KA from wcSCC, offering a promising non-invasive tool for preliminary diagnosis and treatment planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"435-443"},"PeriodicalIF":2.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert M. Hoffmann MD, Mark I. Neuman MD, MPH, Michelle Du BS, Michael C. Monuteaux ScD, Andrew F. Miller MD, Jeffrey T. Neal MD, Kyle A. Nelson MD, Cynthia A. Gravel MD
Objective
We sought to assess whether the presence and extent of lung ultrasound (LUS) findings were associated with asthma exacerbation severity in children.
Methods
We enrolled a convenience sample of patients aged 5–18 years presenting with acute asthma exacerbation to a tertiary care pediatric emergency department. Severity of an asthma exacerbation (mild, moderate, severe) was assessed within 1 hour of the LUS using the Hospital Asthma Severity Score, a validated asthma assessment tool. LUS was performed by trained pediatric emergency providers. The presence of LUS findings (B-lines, consolidations, pleural effusion, and pleural line abnormalities) was assessed using a standardized criterion based on consensus guidelines.
Results
A total of 111 patients with a median age of 8 years (interquartile range 6–12) were enrolled. LUS was positive in 57% of patients. Pleural line abnormalities were observed in 34%, B-lines in 29%, consolidations <1 cm in 24%, and consolidations ≥1 cm in 7%. Patients with moderate and severe asthma exacerbations were more likely to have any B-lines (31% and 43%, respectively) than patients with mild exacerbations (12%; P = .021); however, the presence of ≥3 B-lines or confluent B-lines did not differ across severity groups. The presence of other findings did not differ based on asthma severity.
Conclusions
LUS findings are observed in a substantial portion of children presenting with asthma exacerbations. B-lines were the only LUS finding significantly associated with asthma severity, while lung consolidations <1 cm and >1 cm were not correlated with severity. These findings provide valuable information for the diagnostic use of LUS in pediatric patients with asthma exacerbation.
{"title":"Lung Ultrasound Findings in Children With Asthma Exacerbations","authors":"Robert M. Hoffmann MD, Mark I. Neuman MD, MPH, Michelle Du BS, Michael C. Monuteaux ScD, Andrew F. Miller MD, Jeffrey T. Neal MD, Kyle A. Nelson MD, Cynthia A. Gravel MD","doi":"10.1002/jum.16617","DOIUrl":"10.1002/jum.16617","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We sought to assess whether the presence and extent of lung ultrasound (LUS) findings were associated with asthma exacerbation severity in children.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled a convenience sample of patients aged 5–18 years presenting with acute asthma exacerbation to a tertiary care pediatric emergency department. Severity of an asthma exacerbation (mild, moderate, severe) was assessed within 1 hour of the LUS using the Hospital Asthma Severity Score, a validated asthma assessment tool. LUS was performed by trained pediatric emergency providers. The presence of LUS findings (B-lines, consolidations, pleural effusion, and pleural line abnormalities) was assessed using a standardized criterion based on consensus guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 111 patients with a median age of 8 years (interquartile range 6–12) were enrolled. LUS was positive in 57% of patients. Pleural line abnormalities were observed in 34%, B-lines in 29%, consolidations <1 cm in 24%, and consolidations ≥1 cm in 7%. Patients with moderate and severe asthma exacerbations were more likely to have any B-lines (31% and 43%, respectively) than patients with mild exacerbations (12%; <i>P</i> = .021); however, the presence of ≥3 B-lines or confluent B-lines did not differ across severity groups. The presence of other findings did not differ based on asthma severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LUS findings are observed in a substantial portion of children presenting with asthma exacerbations. B-lines were the only LUS finding significantly associated with asthma severity, while lung consolidations <1 cm and >1 cm were not correlated with severity. These findings provide valuable information for the diagnostic use of LUS in pediatric patients with asthma exacerbation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"535-544"},"PeriodicalIF":2.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiwen Deng MD, Qiao Zeng MD, Yu Zhao MD, Zhen Hu MD, Changmiao Zhan MD, Liangyun Guo PhD, Binghuang Lai MD, Zhiping Huang MD, Zhiyong Fu MD, Chunquan Zhang PhD
Objectives
To evaluate the value of radiomics based on ultrasonography in differentiating follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) and construct a tool for preoperative noninvasive predicting FTC and FTA.
Methods
The clinical data and ultrasound images of 389 patients diagnosed with FTC or FTA postoperatively were retrospectively analyzed at 3 institutions from January 2017 to December 2023. Patients in our hospital were randomly assigned in a 7:3 ratio to training cohort and validation cohort. External test cohort consisted of data collected from other 2 hospitals. Radiomics features were used to develop models based on different machine learning classifiers. A combined model was developed combining radiomics features with clinical characteristics and a nomogram was depicted. The performance of the models was assessed by area under the receiver operating characteristic curve (AUC), calibration curve and decision curve.
Results
Radiomics model based on random forest showed best performance in discriminating FTC and FTA, with AUCs 0.880 (95% confidence interval [CI]: 0.8290–0.9308), 0.871 (95% CI: 0.7690–0.9734), and 0.821 (95% CI: 0.7036–0.9389) in training, validation, and test cohort, respectively. The combined model presented better efficacy comparing with clinical model and radiomics model, with AUCs 0.883 (95% CI: 0.8359–0.9295), 0.874 (95% CI: 0.7873–0.9615), and 0.876 (0.7809–0.9714) in training, validation, and test cohort, respectively. The calibration curves suggested good consistency and decision curves showed the highest overall clinical benefit for the combined model.
Conclusions
Ultrasound radiomics model based on random forest is feasible to differentiate FTC and FTA, and the combined model is an intuitively noninvasive tool for FTC and FTA preoperative identification.
{"title":"Model Based on Ultrasound Radiomics and Machine Learning to Preoperative Differentiation of Follicular Thyroid Neoplasm","authors":"Yiwen Deng MD, Qiao Zeng MD, Yu Zhao MD, Zhen Hu MD, Changmiao Zhan MD, Liangyun Guo PhD, Binghuang Lai MD, Zhiping Huang MD, Zhiyong Fu MD, Chunquan Zhang PhD","doi":"10.1002/jum.16620","DOIUrl":"10.1002/jum.16620","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the value of radiomics based on ultrasonography in differentiating follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) and construct a tool for preoperative noninvasive predicting FTC and FTA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The clinical data and ultrasound images of 389 patients diagnosed with FTC or FTA postoperatively were retrospectively analyzed at 3 institutions from January 2017 to December 2023. Patients in our hospital were randomly assigned in a 7:3 ratio to training cohort and validation cohort. External test cohort consisted of data collected from other 2 hospitals. Radiomics features were used to develop models based on different machine learning classifiers. A combined model was developed combining radiomics features with clinical characteristics and a nomogram was depicted. The performance of the models was assessed by area under the receiver operating characteristic curve (AUC), calibration curve and decision curve.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Radiomics model based on random forest showed best performance in discriminating FTC and FTA, with AUCs 0.880 (95% confidence interval [CI]: 0.8290–0.9308), 0.871 (95% CI: 0.7690–0.9734), and 0.821 (95% CI: 0.7036–0.9389) in training, validation, and test cohort, respectively. The combined model presented better efficacy comparing with clinical model and radiomics model, with AUCs 0.883 (95% CI: 0.8359–0.9295), 0.874 (95% CI: 0.7873–0.9615), and 0.876 (0.7809–0.9714) in training, validation, and test cohort, respectively. The calibration curves suggested good consistency and decision curves showed the highest overall clinical benefit for the combined model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ultrasound radiomics model based on random forest is feasible to differentiate FTC and FTA, and the combined model is an intuitively noninvasive tool for FTC and FTA preoperative identification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"567-579"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Size Differences of Breast Cancer and Benign Tumors Measured by Two-Dimensional Ultrasound and Contrast-Enhanced Ultrasound","authors":"Hideaki Ishida MD, PhD, Hiroko Naganuma MD, PhD","doi":"10.1002/jum.16621","DOIUrl":"10.1002/jum.16621","url":null,"abstract":"","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"589-590"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Sun MD, Jianqiu Huang MD, Jinhua Shao PhD, Jianwen Luo PhD, Qiong He PhD, Ligang Cui MD
Objectives
The aim of this study was to use quantitative ultrasound (QUS) parameters to assess the muscle mass and quality in patients with lymphoma. Additionally, the study aimed to investigate the relationship between these QUS parameters and post-chemotherapy myelosuppression.
Methods
The study cohort comprised 202 patients diagnosed with lymphoma (105 males, 97 females; mean age 57.0 ± 14.9 years). The skeletal muscle index (SMI) and mean skeletal muscle density (SMD) were measured on CT and used as the gold standards to evaluate low skeletal muscle mass and quality. The muscle thickness (MT) of the forearm flexor and extensor muscles was measured in both the relaxed and contracted states, while the normalized non-linear parameter B/A (MusQBOX.NLP) and normalized mean intensity (MusQBOX.NMI) were extracted from retained ultrasound radiofrequency signals. The correlations between the QUS parameters and grip strength were assessed. Models were constructed using these QUS parameters to predict low SMI and SMD, and to evaluate whether these factors were independently associated with post-chemotherapy myelosuppression.
Results
The MT in both the relaxed and contracted states exhibited the strongest correlations with grip strength, while the MusQBOX.NLP and MusQBOX.NMI were only weakly correlated with grip strength. Models incorporating QUS parameters to predict low SMI and SMD achieved high area under the receiver operating characteristic curve values. The MT, MusQBOX.NLP, and MusQBOX.NMI were independent factors associated with post-chemotherapy myelosuppression.
Conclusions
QUS parameters show promise in characterizing muscle strength, mass, and quality. They are also independent factors influencing post-chemotherapy myelosuppression.
{"title":"Quantitative Ultrasound Parameters as Predictors of Chemotherapy Toxicity in Lymphoma","authors":"Yang Sun MD, Jianqiu Huang MD, Jinhua Shao PhD, Jianwen Luo PhD, Qiong He PhD, Ligang Cui MD","doi":"10.1002/jum.16618","DOIUrl":"10.1002/jum.16618","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study was to use quantitative ultrasound (QUS) parameters to assess the muscle mass and quality in patients with lymphoma. Additionally, the study aimed to investigate the relationship between these QUS parameters and post-chemotherapy myelosuppression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study cohort comprised 202 patients diagnosed with lymphoma (105 males, 97 females; mean age 57.0 ± 14.9 years). The skeletal muscle index (SMI) and mean skeletal muscle density (SMD) were measured on CT and used as the gold standards to evaluate low skeletal muscle mass and quality. The muscle thickness (MT) of the forearm flexor and extensor muscles was measured in both the relaxed and contracted states, while the normalized non-linear parameter B/A (MusQBOX.NLP) and normalized mean intensity (MusQBOX.NMI) were extracted from retained ultrasound radiofrequency signals. The correlations between the QUS parameters and grip strength were assessed. Models were constructed using these QUS parameters to predict low SMI and SMD, and to evaluate whether these factors were independently associated with post-chemotherapy myelosuppression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The MT in both the relaxed and contracted states exhibited the strongest correlations with grip strength, while the MusQBOX.NLP and MusQBOX.NMI were only weakly correlated with grip strength. Models incorporating QUS parameters to predict low SMI and SMD achieved high area under the receiver operating characteristic curve values. The MT, MusQBOX.NLP, and MusQBOX.NMI were independent factors associated with post-chemotherapy myelosuppression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>QUS parameters show promise in characterizing muscle strength, mass, and quality. They are also independent factors influencing post-chemotherapy myelosuppression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"545-555"},"PeriodicalIF":2.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present study was to assess the reliability of aponeurosis and muscle thickness of the hamstrings using ultrasound (US).
Methods
US images were captured from the semitendinosus (ST) and biceps femoris long head (BFlh) of 30 individuals (15 females), undergoing two testing sessions with a 24-hour interval. Measurements were taken at six sites along the thigh at two knee angles (0° = full extension and 90°) in prone position. Aponeurosis and muscle thickness across the entire length of ST and BFlh were evaluated using computational image segmentation which generated ~360 data points per participant.
Results
The intraclass correlation coefficients ranged from 0.937 to 0.998 while the standard error of measurement varied from 0.88 to 2.72% for superficial aponeurosis, from 1.41 to 2.29% for deep aponeurosis, and from 1.50 to 4.22% for muscle thickness. The minimal detectable change ranged from 2.44 to 7.56% for the superficial aponeurosis, from 3.57 to 6.27% for deep aponeurosis, and from 4.17 to 11.70% for BF and ST muscle thickness.
Conclusions
Evaluation of hamstring aponeurosis and muscle thickness measurements at rest displayed very high reliability and, hence, such measurements can be used to diagnose changes in thickness due to injury or exercise interventions.
{"title":"Reliability of Semitendinosus and Biceps Femoris Aponeurosis Thickness Using B-Mode Ultrasound","authors":"Chrysostomos Sahinis PhD, Eleftherios Kellis PhD","doi":"10.1002/jum.16616","DOIUrl":"10.1002/jum.16616","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of the present study was to assess the reliability of aponeurosis and muscle thickness of the hamstrings using ultrasound (US).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>US images were captured from the semitendinosus (ST) and biceps femoris long head (BFlh) of 30 individuals (15 females), undergoing two testing sessions with a 24-hour interval. Measurements were taken at six sites along the thigh at two knee angles (0° = full extension and 90°) in prone position. Aponeurosis and muscle thickness across the entire length of ST and BFlh were evaluated using computational image segmentation which generated ~360 data points per participant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The intraclass correlation coefficients ranged from 0.937 to 0.998 while the standard error of measurement varied from 0.88 to 2.72% for superficial aponeurosis, from 1.41 to 2.29% for deep aponeurosis, and from 1.50 to 4.22% for muscle thickness. The minimal detectable change ranged from 2.44 to 7.56% for the superficial aponeurosis, from 3.57 to 6.27% for deep aponeurosis, and from 4.17 to 11.70% for BF and ST muscle thickness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Evaluation of hamstring aponeurosis and muscle thickness measurements at rest displayed very high reliability and, hence, such measurements can be used to diagnose changes in thickness due to injury or exercise interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"521-534"},"PeriodicalIF":2.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diego Lerma-Puertas PhD, Ana Aguerri MD, Gema Pardina MD, Cristina Paules PhD, David Lerma-Irureta MD, Daniel Oros PhD, Sara Ruiz-Martínez PhD
Management of suspected large for gestational age (LGA) fetuses remains unclear because ultrasound-estimated fetal weight (EFW) is not accurate. This was a systematic review of observational studies on fetal soft tissues measurements used alone or in combination to create a new EFW formula, to improve the screening for LGA fetuses. Studies were scored using a predefined set of independently agreed methodological criteria and an overall quality score was assigned for study design, statistical analysis, and reporting methods. There is a need to standardize methodologies for soft fetal tissue measurements. We propose a set of suggestions for this purpose.
{"title":"Methodology Used in Studies Aimed at Measuring Fetal Soft Tissues by 2D Ultrasound for the Screening of Large for Gestational Age Fetuses","authors":"Diego Lerma-Puertas PhD, Ana Aguerri MD, Gema Pardina MD, Cristina Paules PhD, David Lerma-Irureta MD, Daniel Oros PhD, Sara Ruiz-Martínez PhD","doi":"10.1002/jum.16614","DOIUrl":"10.1002/jum.16614","url":null,"abstract":"<p>Management of suspected large for gestational age (LGA) fetuses remains unclear because ultrasound-estimated fetal weight (EFW) is not accurate. This was a systematic review of observational studies on fetal soft tissues measurements used alone or in combination to create a new EFW formula, to improve the screening for LGA fetuses. Studies were scored using a predefined set of independently agreed methodological criteria and an overall quality score was assigned for study design, statistical analysis, and reporting methods. There is a need to standardize methodologies for soft fetal tissue measurements. We propose a set of suggestions for this purpose.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"365-379"},"PeriodicalIF":2.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kenneth B. Bader PhD, Frederic Padilla PhD, Kevin J. Haworth PhD, Nicholas Ellens PhD, Diane Dalecki PhD, Douglas L. Miller PhD, Keith A. Wear PhD, Bioeffects Committee of the American Institute of Ultrasound in Medicine
A 2012 review of therapeutic ultrasound was published to educate researchers and physicians on potential applications and concerns for unintended bioeffects (doi: 10.7863/jum.2012.31.4.623). This review serves as an update to the parent article, highlighting advances in therapeutic ultrasound over the past 12 years. In addition to general mechanisms for bioeffects produced by therapeutic ultrasound, current applications, and the pre-clinical and clinical stages are outlined. An overview is provided for image guidance methods to monitor and assess treatment progress. Finally, other topics relevant for the translation of therapeutic ultrasound are discussed, including computational modeling, tissue-mimicking phantoms, and quality assurance protocols.
{"title":"Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update","authors":"Kenneth B. Bader PhD, Frederic Padilla PhD, Kevin J. Haworth PhD, Nicholas Ellens PhD, Diane Dalecki PhD, Douglas L. Miller PhD, Keith A. Wear PhD, Bioeffects Committee of the American Institute of Ultrasound in Medicine","doi":"10.1002/jum.16611","DOIUrl":"10.1002/jum.16611","url":null,"abstract":"<p>A 2012 review of therapeutic ultrasound was published to educate researchers and physicians on potential applications and concerns for unintended bioeffects (doi: 10.7863/jum.2012.31.4.623). This review serves as an update to the parent article, highlighting advances in therapeutic ultrasound over the past 12 years. In addition to general mechanisms for bioeffects produced by therapeutic ultrasound, current applications, and the pre-clinical and clinical stages are outlined. An overview is provided for image guidance methods to monitor and assess treatment progress. Finally, other topics relevant for the translation of therapeutic ultrasound are discussed, including computational modeling, tissue-mimicking phantoms, and quality assurance protocols.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"381-433"},"PeriodicalIF":2.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Double aortic arch with an atretic left aortic arch can resemble like a right aortic arch with an aberrant left subclavian artery or a right aortic arch with mirror image branching. Differentiating these closely resembling fetal aortic arch abnormalities is important for proper prenatal counselling and immediate neonatal evaluation. In this pictorial essay, we describe these three cases and its typical imaging features using conventional and four-dimensional echocardiography.
{"title":"Differentiating Closely Resembling Fetal Aortic Arch Abnormalities Using Conventional and Four-Dimensional Echocardiography","authors":"Balaganesh Karmegaraj MD, DM, Sowmya Vijayakumar MD","doi":"10.1002/jum.16615","DOIUrl":"10.1002/jum.16615","url":null,"abstract":"<p>Double aortic arch with an atretic left aortic arch can resemble like a right aortic arch with an aberrant left subclavian artery or a right aortic arch with mirror image branching. Differentiating these closely resembling fetal aortic arch abnormalities is important for proper prenatal counselling and immediate neonatal evaluation. In this pictorial essay, we describe these three cases and its typical imaging features using conventional and four-dimensional echocardiography.</p>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"581-588"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa M. Trommelen MD, Robert A. De Leeuw MD, PhD, Thierry Van den Bosch MD, PhD, Judith A. F. Huirne MD, PhD
Objectives
The reported prevalence of adenomyosis ranges widely due to different study populations, diagnostic tests and criteria. Categorizing the severity of disease may prove important. This study aims to develop a semi-quantifiable sonographic method to grade the severity of adenomyosis and assess the feasibility and interobserver reliability of this method.
Methods
Cross-sectional pilot study performed at a gynecology outpatient clinic, included 35 premenopausal women with adenomyosis, not taking hormonal medication. Diagnosis required ≥1 direct sonographic feature of adenomyosis. Two-dimensional (2D) grayscale video clips and 3-dimensional (3D) volumes of the uterus of the first 5 patients were evaluated using 6 offline methods to assess feasibility. Feasible methods were analyzed for interobserver (n = 3) reliability (Fleiss kappa or intraclass correlation) and compared with current ultrasound methods (Cohen's weighted kappa and Spearman's rank correlation). Current methods include real-time estimation (mild/moderate/severe) and counting the individual sonographic features.
Results
“eXtended Imaging virtual organ computer-aided analysis (XI VOCAL) counting” (counting affected slices of 20 parallel slices in the 3D volume), “Multiplanar and 3D rendering (MPR) estimation” (grading volume by eyeballing in multiplanar render mode), and “2D-clip estimation” (grading volume in 2D-clips) emerged as feasible methods. “XI VOCAL counting” and “2D-clip estimation” demonstrated good interobserver reliability, whereas “MPR estimation” had poor reliability. Comparison with real-time estimation showed moderate reliability with all methods. “XI VOCAL counting” and “MPR estimation” correlated positively with the number of sonographic features.
Conclusion
“XI VOCAL counting” demonstrated to be feasible with good interobserver reliability to assess the severity of adenomyosis in an objective, systematic, and semi-quantifiable fashion and should be validated with large-scale studies for future use. Future studies should also explore the association between sonographic severity and symptoms of adenomyosis.
{"title":"Grading Sonographic Severity of Adenomyosis","authors":"Lisa M. Trommelen MD, Robert A. De Leeuw MD, PhD, Thierry Van den Bosch MD, PhD, Judith A. F. Huirne MD, PhD","doi":"10.1002/jum.16612","DOIUrl":"10.1002/jum.16612","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The reported prevalence of adenomyosis ranges widely due to different study populations, diagnostic tests and criteria. Categorizing the severity of disease may prove important. This study aims to develop a semi-quantifiable sonographic method to grade the severity of adenomyosis and assess the feasibility and interobserver reliability of this method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional pilot study performed at a gynecology outpatient clinic, included 35 premenopausal women with adenomyosis, not taking hormonal medication. Diagnosis required ≥1 direct sonographic feature of adenomyosis. Two-dimensional (2D) grayscale video clips and 3-dimensional (3D) volumes of the uterus of the first 5 patients were evaluated using 6 offline methods to assess feasibility. Feasible methods were analyzed for interobserver (n = 3) reliability (Fleiss kappa or intraclass correlation) and compared with current ultrasound methods (Cohen's weighted kappa and Spearman's rank correlation). Current methods include real-time estimation (mild/moderate/severe) and counting the individual sonographic features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>“eXtended Imaging virtual organ computer-aided analysis (XI VOCAL) counting” (counting affected slices of 20 parallel slices in the 3D volume), “Multiplanar and 3D rendering (MPR) estimation” (grading volume by eyeballing in multiplanar render mode), and “2D-clip estimation” (grading volume in 2D-clips) emerged as feasible methods. “XI VOCAL counting” and “2D-clip estimation” demonstrated good interobserver reliability, whereas “MPR estimation” had poor reliability. Comparison with real-time estimation showed moderate reliability with all methods. “XI VOCAL counting” and “MPR estimation” correlated positively with the number of sonographic features.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>“XI VOCAL counting” demonstrated to be feasible with good interobserver reliability to assess the severity of adenomyosis in an objective, systematic, and semi-quantifiable fashion and should be validated with large-scale studies for future use. Future studies should also explore the association between sonographic severity and symptoms of adenomyosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17563,"journal":{"name":"Journal of Ultrasound in Medicine","volume":"44 3","pages":"495-506"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jum.16612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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