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Reporting Perinatal Substance Use to Child Protective Services: Obstetric Provider Perspectives on the Impact on Care. 向儿童保护服务机构报告围产期药物使用情况:产科医生对护理影响的看法。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI: 10.1089/jwh.2023.0822
Joy S Kaufman, Kimberly A Yonkers, Caro Maltz, Carolyn M Friedhoff, Amalia Londoño Tobon, Amanda Mele, Madeleine Tessier-Kay, Olga Grechukhina, Heather Lipkind, Nancy Byatt, Ariadna Forray

Objective: To understand obstetric provider perspectives on child protective services (CPS)-mandated reporting requirements and how they affect care for pregnant and postpartum patients with opioid use disorder (OUD). Methods: Key informant interviews were conducted virtually with obstetricians, nurse practitioners, and social workers caring for obstetric patients (n = 12). Providers were asked about their experience as mandated reporters working with patients with OUD. Transcripts were independently coded by two staff, and content analysis was used to identify themes. Results: Our analysis resulted in six thematic areas, including CPS-mandated strengths, concerns related to CPS reporting requirements, implementation of mandates, supporting patients after CPS report, communication between stakeholders, and the impact on care. Providers noted that the fear of CPS involvement causes some patients to delay or not engage in care. Other patients are hesitant to accept medications for OUD for fear of CPS involvement. The inconsistencies in how reporting mandates are applied and how CPS handles cases make communication about the policies challenging for providers and create anxiety for patients. Conclusions: The results of this study indicate that mandated reporting requirements and the potential for CPS involvement are perceived to have minimal positive effects on perinatal individuals with OUD and may negatively affect patients and their care. Clinicaltrials.gov number: NCT04240392.

目的:了解产科医疗服务提供者对儿童保护服务 (CPS) 强制报告要求的看法,以及这些要求如何影响对患有阿片类药物使用障碍 (OUD) 的孕妇和产后患者的护理。方法:对产科医生、执业护士和护理产科病人的社会工作者(n = 12)进行了虚拟关键信息访谈。询问了医疗服务提供者作为法定报告人与 OUD 患者打交道的经历。访谈记录由两名工作人员独立编码,并通过内容分析确定主题。结果:我们的分析得出了六个主题领域,包括 CPS 强制报告的优势、与 CPS 报告要求相关的担忧、强制报告的实施、CPS 报告后对患者的支持、利益相关者之间的沟通以及对护理的影响。医疗服务提供者指出,对 CPS 介入的恐惧导致一些患者推迟或不参与护理。还有一些患者因为害怕 CPS 的介入而迟迟不愿接受治疗 OUD 的药物。在如何执行报告任务和 CPS 如何处理案件方面存在的不一致,使得医疗服务提供者在政策沟通方面面临挑战,并给患者带来焦虑。结论:本研究结果表明,强制报告要求和 CPS 参与的可能性被认为对患有 OUD 的围产期患者的积极影响微乎其微,并可能对患者及其护理产生负面影响。Clinicaltrials.gov 编号:NCT04240392:NCT04240392。
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引用次数: 0
Counseling Women About Sexual Health Effects of Contraceptives. 就避孕药对性健康的影响为妇女提供咨询。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-06-07 DOI: 10.1089/jwh.2023.0625
Suneela Vegunta, Lisa E Houston, Nicola A Nicholson, Paru S David

Background: Choosing a contraceptive method is a pivotal decision for patients, whereas health care professionals (HCPs) face challenges in providing suitable recommendations. Adverse sexual effects often lead to dissatisfaction and discontinuation of contraceptives, underscoring the importance of thorough counseling and shared decision making between HCPs and patients. Objective: This article aims to investigate the relationship between contraceptive methods and female sexual function through a comprehensive review of available literature, emphasizing the importance of considering sexual health in contraceptive prescription and management. Methods: A systematic analysis of existing literature, incorporating studies utilizing validated sexual health questionnaires, was conducted to elucidate the intricate interplay between contraceptives and female sexual function. Results: The review encompasses various contraceptive methods, including combined hormonal contraceptives, progestin-only pills, depot medroxyprogesterone acetate, subdermal contraceptive implants, hormonal intrauterine devices, permanent sterilization, and barrier methods. Insights gleaned from the analysis shed light on the impact of these methods on female sexual health. Conclusion: Comprehensive understanding of the effects of contraceptives on female sexual function is crucial for both HCPs and patients. By integrating sexual health considerations into contraceptive surveillance, compliance can be improved, contraceptive efficacy optimized, and the risk of unwanted pregnancies minimized. This review underscores the significance of tailored counseling and shared decision making in contraceptive management, particularly for cisgender women.

背景:选择避孕方法对患者来说是一个关键的决定,而医疗保健专业人员(HCP)在提供合适的建议时却面临着挑战。性方面的不良反应往往会导致对避孕药具的不满和停用,这就强调了全面咨询和医护人员与患者共同决策的重要性。目的:本文旨在研究避孕药具与性功能障碍之间的关系:本文旨在通过全面回顾现有文献,研究避孕方法与女性性功能之间的关系,强调在避孕处方和管理中考虑性健康的重要性。方法:对现有文献进行系统分析:通过对现有文献进行系统分析,并结合使用有效性健康问卷进行的研究,阐明避孕药具和女性性功能之间错综复杂的相互作用。结果综述涵盖了各种避孕方法,包括复合荷尔蒙避孕药、纯孕激素避孕药、醋酸甲羟孕酮、皮下避孕植入物、荷尔蒙宫内节育器、永久绝育和屏障法。从分析中获得的启示揭示了这些方法对女性性健康的影响。结论全面了解避孕药物对女性性功能的影响对保健医生和患者都至关重要。通过将性健康因素纳入避孕监测,可以提高依从性,优化避孕效果,并将意外怀孕的风险降至最低。这篇综述强调了在避孕管理中进行有针对性的咨询和共同决策的重要性,尤其是对顺性别女性而言。
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引用次数: 0
Understanding and Offering Counseling to Your Patients about the First Over the Counter Progestin-Only Oral Contraceptive (OPill®). 了解首款非处方纯孕激素口服避孕药 (OPill®) 并为患者提供相关咨询。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-09-16 DOI: 10.1089/jwh.2024.0896
Suneela Vegunta, Vivian C Iloabuchi, Sara Shihab
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引用次数: 0
Analysis of Faculty Gender and Race in Scholarly Achievements in Academic Neurology. 神经病学学术成就中的教师性别和种族分析。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-07-10 DOI: 10.1089/jwh.2023.0983
Sima I Patel, Parneet Grewal, Christa O'Hana S Nobleza, Neishay Ayub, Kim-Eng Ky, Doris H Kung, Suma Shah, Myriam Abdennadher, Halley B Alexander, Natasha Frost, Kamala Rodrigues, Sarah Durica, Seema Nagpal, June Yoshii-Contreras, Katherine Zarroli, Padmaja Sudhakar, Chen Zhao, Sol De Jesus, Deborah Bradshaw, Nicole Brescia, Nancy Foldvary-Schaefer, Laura Tormoehlen, Laurie Gutmann, Sneha Mantri, Ailing Yang, Annie He, Cynthia Zheng, Mark Fiecas, Julie K Silver, Alyssa F Westring, Sasha Alick-Lindstrom, Jane B Allendorfer

Background: Intersection of gender and race and/or ethnicity in academic medicine is understudied; we aim to understand these factors in relation to scholarly achievements for neurology faculty. Methods: Faculty from 19 US neurology departments completed a survey (2021-2022) to report rank, leadership positions, publications, funded projects, awards, and speaker invitations. Regression analyses examined effects of gender, race, and their intersectionality on these achievements. Women, Black/Indigenous/People of Color (BIPOC), and BIPOC women were comparator groups. Results: Four hundred sixty-two faculty responded: 55% women, 43% men; 31% BIPOC, 63% White; 21% BIPOC women, 12% BIPOC men, 36% White women, 31% White men. Men and White faculty are more likely to be full professors than women and BIPOC faculty. The number of leadership positions, funded projects, awards, and speaker invitations are significantly greater in White compared to BIPOC faculty. Relative to BIPOC women, the number of leadership positions is significantly higher among BIPOC men, White women, and White men. Publication numbers for BIPOC men are lower, number of funded projects and speaker invitations for White women are higher, and number of awards among White men and White women is higher compared to BIPOC women. Discussion: Our study highlights that inequities in academic rank, award number, funded projects, speakership invitations, and leadership roles disproportionately impacted BIPOC women. More studies are needed to evaluate gender and race and/or ethnicity intersectionality effects on faculty achievements, reasons for inequities, recognition, and potential solutions.

背景:我们旨在了解这些因素与神经病学教师学术成就的关系。研究方法来自美国 19 个神经病学系的教师完成了一项调查(2021-2022 年),报告了他们的职级、领导职位、出版物、资助项目、奖项和演讲邀请。回归分析研究了性别、种族及其交叉性对这些成就的影响。女性、黑人/土著/有色人种 (BIPOC) 和 BIPOC 女性为比较组。结果:422 名教职员工做出了回应:55%为女性,43%为男性;31%为黑人/原住民/有色人种,63%为白人;21%为黑人/原住民/有色人种女性,12%为黑人/原住民/有色人种男性,36%为白人女性,31%为白人男性。男性和白人教师比女性和黑人、印度裔和华裔教师更有可能成为全职教授。在领导职位、资助项目、奖项和演讲邀请的数量上,白人教员明显多于女性和男性。与 BIPOC 女性相比,BIPOC 男性、白人女性和白人男性的领导职位数量明显较多。与黑人、印度裔和华裔女性相比,白人、印度裔和华裔男性的出版物数量较少,白人女性的资助项目和演讲邀请数量较多,白人男性和白人女性的获奖数量较多。讨论:我们的研究突出表明,在学术级别、获奖数量、资助项目、演讲邀请和领导角色方面的不平等对 BIPOC 女性的影响尤为严重。需要进行更多的研究,以评估性别、种族和/或民族交叉性对教师成就的影响、不平等的原因、认可度和潜在的解决方案。
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引用次数: 0
A Prospective Study on Lifestyle Factors, Body Mass Index Changes, and Lipitension Risk in Japanese Young and Middle-Aged Women. 关于日本中青年女性生活方式因素、体重指数变化和血脂风险的前瞻性研究。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-07-16 DOI: 10.1089/jwh.2024.0073
Rupa Singh, Jou-Yin Chen, Steven R Hawks, Yukiko Wagatsuma

Background: This study investigates how lifestyle factors and westernization contribute to obesity and examines the influence of body mass index (BMI) changes and lifestyle factors on "lipitension," a significant risk factor for heart disease and metabolic syndrome. Methods: This prospective study focused on women aged 20-64 without pre-existing hypertension and dyslipidemia who underwent regular medical checkups between April 2016 and March 2022. Anthropometric measurements and blood pressure, along with low-density lipoprotein, high-density lipoprotein, and triglycerides levels, were assessed. Results: Over an average 46.5-month follow-up, 11.5% of initially healthy young and middle-aged women developed lipitension. Categorizing participants based on BMI changes revealed stable (63.8%), decreased (12.5%), and increased (23.8%) groups within this 11.5%. Increased BMI is linked with a heightened hazard risk for lipitension. Women with increased BMI who refrained from snacking (aHR [95% confidence interval (CI)] = 2.750 [1.433-5.279]), avoided late-night eating (aHR [95% CI] = 1.346 [1.032-1.754]), and engaged in alcohol consumption (aHR [95% CI] = 2.037 [1.138-3.646]) showed an elevated risk. Conversely, within the decreased BMI group, behaviors like skipping breakfast (aHR [95% CI] = 0.190 [0.047-0.764]), eating quickly (aHR [95% CI] = 0.457 [0.215-0.972]), and not eating late (aHR [95% CI] = 0.665 [0.467-0.948]) were associated to a reduced lipitension. Subgroup analysis for women with BMI <23 revealed specific behaviors influencing lipitension risk in both BMI-increased and BMI-stable groups. Conclusion: Customized interventions, including for women with BMI <23, enhance heart health, mitigating global lifestyle diseases and obesity.

研究背景本研究探讨了生活方式因素和西方化是如何导致肥胖的,并研究了体重指数(BMI)变化和生活方式因素对 "血脂升高 "的影响,"血脂升高 "是心脏病和代谢综合征的一个重要风险因素。研究方法这项前瞻性研究的对象是 20-64 岁的女性,她们在 2016 年 4 月至 2022 年 3 月期间接受了定期体检,但未患有高血压和血脂异常。对人体测量数据、血压以及低密度脂蛋白、高密度脂蛋白和甘油三酯水平进行了评估。结果:在平均 46.5 个月的随访期间,11.5% 最初健康的中青年女性患上了脂血症。根据体重指数的变化对参与者进行分类,发现在这 11.5%的参与者中,有稳定组(63.8%)、下降组(12.5%)和上升组(23.8%)。体重指数(BMI)的增加与血脂升高的危险风险有关。体重指数增加的妇女如果不吃零食(aHR [95% 置信区间 (CI)] = 2.750 [1.433-5.279])、避免深夜进食(aHR [95% CI] = 1.346 [1.032-1.754])和饮酒(aHR [95% CI] = 2.037 [1.138-3.646]),则风险会升高。相反,在体重指数下降组中,不吃早餐(aHR [95% CI] = 0.190 [0.047-0.764])、快速进食(aHR [95% CI] = 0.457 [0.215-0.972])和不晚饭(aHR [95% CI] = 0.665 [0.467-0.948])等行为与血脂升高有关。对有体重指数(BMI)的妇女进行分组分析 得出结论:定制干预措施,包括针对体重指数(BMI)女性的干预措施
{"title":"A Prospective Study on Lifestyle Factors, Body Mass Index Changes, and Lipitension Risk in Japanese Young and Middle-Aged Women.","authors":"Rupa Singh, Jou-Yin Chen, Steven R Hawks, Yukiko Wagatsuma","doi":"10.1089/jwh.2024.0073","DOIUrl":"10.1089/jwh.2024.0073","url":null,"abstract":"<p><p><b><i>Background:</i></b> This study investigates how lifestyle factors and westernization contribute to obesity and examines the influence of body mass index (BMI) changes and lifestyle factors on \"lipitension,\" a significant risk factor for heart disease and metabolic syndrome. <b><i>Methods:</i></b> This prospective study focused on women aged 20-64 without pre-existing hypertension and dyslipidemia who underwent regular medical checkups between April 2016 and March 2022. Anthropometric measurements and blood pressure, along with low-density lipoprotein, high-density lipoprotein, and triglycerides levels, were assessed. <b><i>Results:</i></b> Over an average 46.5-month follow-up, 11.5% of initially healthy young and middle-aged women developed lipitension. Categorizing participants based on BMI changes revealed stable (63.8%), decreased (12.5%), and increased (23.8%) groups within this 11.5%. Increased BMI is linked with a heightened hazard risk for lipitension. Women with increased BMI who refrained from snacking (aHR [95% confidence interval (CI)] = 2.750 [1.433-5.279]), avoided late-night eating (aHR [95% CI] = 1.346 [1.032-1.754]), and engaged in alcohol consumption (aHR [95% CI] = 2.037 [1.138-3.646]) showed an elevated risk. Conversely, within the decreased BMI group, behaviors like skipping breakfast (aHR [95% CI] = 0.190 [0.047-0.764]), eating quickly (aHR [95% CI] = 0.457 [0.215-0.972]), and not eating late (aHR [95% CI] = 0.665 [0.467-0.948]) were associated to a reduced lipitension. Subgroup analysis for women with BMI <23 revealed specific behaviors influencing lipitension risk in both BMI-increased and BMI-stable groups. <b><i>Conclusion:</i></b> Customized interventions, including for women with BMI <23, enhance heart health, mitigating global lifestyle diseases and obesity.</p>","PeriodicalId":17636,"journal":{"name":"Journal of women's health","volume":" ","pages":"1576-1586"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies and Resources for Academic Success in Neurology. 神经病学学术成功的策略和资源。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-07-16 DOI: 10.1089/jwh.2024.0609
Alexis N Simpkins
{"title":"Strategies and Resources for Academic Success in Neurology.","authors":"Alexis N Simpkins","doi":"10.1089/jwh.2024.0609","DOIUrl":"10.1089/jwh.2024.0609","url":null,"abstract":"","PeriodicalId":17636,"journal":{"name":"Journal of women's health","volume":" ","pages":"1429-1430"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Management of Fibroids: A Changing Landscape. 子宫肌瘤的手术治疗:不断变化的格局。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-10-07 DOI: 10.1089/jwh.2024.0131
Lulu Yu, Regina Huang, Chioma Okuagu, Elise Bardawil, Joyce Balls-Berry, Whitney Trotter Ross

Background: Uterine fibroids affect patients' quality of life and contribute significantly to health care costs. Studies from 2009 to 2011 demonstrated that fibroids disproportionately affect Black women, with lower odds of uterine preservation and minimally invasive approaches. Objective: This is a retrospective cohort study of data abstracted from the National Surgical Quality Improvement Program database from 2015 to 2019 examining trends in surgical management of uterine fibroids and exploring disparities in surgical approach in a modern cohort. Results: In total, 52,909 women underwent hysterectomy and 15,485 women underwent myomectomy between 2015 and 2019. Over the study period, the overall number of surgeries for fibroids increased by 44.2% with minimally invasive hysterectomy responsible for the majority of this increase. The proportion of patients who underwent myomectomy significantly increased (20.85% to 24.62%, p value <0.0001), whereas hysterectomy significantly decreased (79.15% to 75.38%, p value <0.0001). Bivariate analysis identified younger age, non-White race, and body mass index (BMI) <25 as significantly associated with performance of myomectomy. Non-Hispanic Black (adjusted odds ratio [aOR]: 3.55, 95% confidence interval [CI]: 3.23-3.89), Asian (aOR: 3.26, 95% CI: 2.80-3.80), and Hispanic Black (aOR: 5.50, 95% CI: 3.29-9.25) women were more likely to undergo myomectomy than non-Hispanic White women. Conclusion: Surgical treatment for fibroids increased over time, shifting toward uterine preservation. Myomectomy performance is associated with lower age and BMI and identifying as a racial and/or ethnic minority. These trends may represent improved access to surgical treatment of fibroids, resulting from the growth of minimally invasive gynecological surgery as a specialty and advocacy for equitable health care for all patients.

背景:子宫肌瘤会影响患者的生活质量,并大大增加医疗成本。2009 年至 2011 年的研究表明,子宫肌瘤对黑人女性的影响尤为严重,她们保留子宫和采用微创方法的几率较低。目的:这是一项回顾性队列研究:这是一项回顾性队列研究,研究对象是从国家外科质量改进计划数据库中摘录的 2015 年至 2019 年的数据,研究子宫肌瘤手术治疗的趋势,并探讨现代队列中手术方法的差异。结果:2015年至2019年期间,共有52909名女性接受了子宫切除术,15485名女性接受了子宫肌瘤剔除术。在研究期间,子宫肌瘤手术总数增加了44.2%,其中微创子宫切除术占了大部分。接受子宫肌瘤剔除术的患者比例明显增加(从20.85%增至24.62%,P值P值 结论:子宫肌瘤手术治疗的增加主要归因于微创子宫切除术:随着时间的推移,子宫肌瘤的手术治疗逐渐转向保留子宫。子宫肌瘤切除术的实施与较低的年龄和体重指数以及少数种族和/或少数族裔身份有关。这些趋势可能表明,随着微创妇科手术这一专科的发展,以及倡导为所有患者提供公平的医疗保健服务,子宫肌瘤手术治疗的可及性有所提高。
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引用次数: 0
Perceived Barriers to Pap Screening Influence Adherence to Screening Recommendations Among Black Women. 黑人妇女对子宫颈抹片筛查的认知障碍影响了对筛查建议的依从性。
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-06-05 DOI: 10.1089/jwh.2023.1024
Adebola Adegboyega, JungHee Kang, Adaeze Aroh, Lovoria B Williams

Objectives: The aim of this study was to determine the Health Belief Model (HBM) constructs associated with Pap screening adherence among a sample of African American and sub-Saharan African immigrant women in the United States. Methods: A descriptive cross-sectional study was conducted via an online survey. Participants were recruited from central Kentucky counties. Ninety-one eligible women participated (mean age 38 ± 12 years), 49.5% identified as African American. Twenty-nine percent indicated never being screened or not being up-to-date. Self-reported demographic data, HBM constructs for Pap screening, and Pap screening history were collected. Bivariate and logistic regressions were performed. Results: There was a significant negative association between perceived barriers and being up-to-date. For every one-point increase in perceived barriers, the odds of being up-to-date decreased by 81%, (p = 0.004; CI: 0.06-0.60), findings from further evaluation of the barrier construct showed that barriers significantly associated with screening include items related to lack of knowledge about where to get a Pap screening, lack of time to attend the screening, screening-associated shame and pain, negligence, and age. There were no other significant HBM constructs associated with up-to-date Pap screening status. There was no difference in perceived barriers between African American and sub-Saharan African women. Conclusions: Despite public health efforts to decrease screening barriers, a perception of barriers exists among Black women. Continued efforts to address screening barriers as well as the perception of barriers are warranted among Black women.

研究目的本研究旨在确定在美国的非裔美国人和撒哈拉以南非洲移民妇女样本中,与坚持巴氏筛查相关的健康信念模型(HBM)结构。研究方法通过在线调查进行了一项描述性横断面研究。参与者来自肯塔基州中部各县。符合条件的 91 名妇女参加了调查(平均年龄为 38 ± 12 岁),49.5% 的妇女被认定为非洲裔美国人。29%的人表示从未接受过筛查或没有接受过最新筛查。收集了自我报告的人口统计学数据、子宫颈抹片筛查的 HBM 结构和子宫颈抹片筛查史。进行了二元回归和逻辑回归。结果显示感知障碍与是否及时接受检查之间存在明显的负相关。对障碍结构的进一步评估结果显示,与筛查显著相关的障碍包括:不知道去哪里做巴氏筛查、没有时间参加筛查、与筛查相关的羞耻感和痛苦、疏忽和年龄。没有其他重要的 HBM 构建与最新的巴氏筛查状况相关。非裔美国妇女和撒哈拉以南非洲妇女在感知障碍方面没有差异。结论:尽管公共卫生部门为减少筛查障碍做出了努力,但黑人妇女仍然认为存在筛查障碍。有必要在黑人妇女中继续努力解决筛查障碍以及对障碍的认知问题。
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引用次数: 0
Initiation of Oral Endocrine Therapy and Survival Benefit Among Women with Early-Stage Breast Cancer. 早期乳腺癌妇女口服内分泌疗法的启动与生存获益
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1089/jwh.2023.0971
Jingjing Qian, Bang Truong

Introduction: Endocrine therapy (ET) is the cornerstone of systemic treatment for patients with estrogen receptor positive breast cancer, but its uptake and adherence need further improvement. This observational study assessed ET initiation and 1-year adherence and its survival benefit among female Medicare beneficiaries with early-stage breast cancer. Materials and Methods: This retrospective cohort study analyzed the linked 2011-2019 Surveillance, Epidemiology, and End Results-Medicare data. Female beneficiaries newly diagnosed with hormone receptor positive, stage I-III breast cancer were included. Beneficiaries who initiated tamoxifen, anastrozole, letrozole, or exemestane within 3 months after cancer diagnosis were defined as initiators (n = 24,289), and those who never initiated these treatments were noninitiators (n = 8,899). Adherence was measured using proportion of days covered (PDC) in the continuous 12 months follow-up period. Multivariable logistic regression models were used to assess factors associated with ET initiation and adherence (PDC ≥ 80%), controlling for covariates. Weighted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause and breast cancer related mortality between initiators and noninitiators and by adherence status. Results: Among eligible female beneficiaries (n = 55,893), 43% initiated ET within 3 months of cancer diagnosis. Among initiators, 77% had PDC ≥ 80% during the first year. Patient's demographics (e.g., older age, race/ethnicity) and baseline health services utilization (e.g., mammography) were associated with ET initiation and adherence. ET initiation and adherence was associated with reduced risk of all-cause (adjusted HR = 0.62, 0.59-0.66; HR = 0.55, 0.53-0.59; respectively) and breast cancer related (adjusted HR = 0.57, 0.50-0.64; HR = 0.41, 0.36-0.47; respectively) mortality compared with noninitiators. Conclusion: Women with early-stage breast cancer who initiate ET and are adherent to treatment may achieve survival benefits compared with noninitiators.

简介内分泌治疗(ET)是雌激素受体阳性乳腺癌患者全身治疗的基石,但其吸收率和依从性需要进一步提高。本观察性研究评估了早期乳腺癌女性医保受益人开始接受 ET 治疗和坚持 ET 治疗 1 年的情况及其对生存的益处。材料与方法:这项回顾性队列研究分析了 2011-2019 年监测、流行病学和最终结果-医疗保险的相关数据。研究纳入了新诊断为激素受体阳性、I-III 期乳腺癌的女性受益人。在癌症确诊后 3 个月内开始使用他莫昔芬、阿那曲唑、来曲唑或依西美坦的受益人被定义为开始治疗者(n = 24,289),从未开始这些治疗的受益人为未开始治疗者(n = 8,899)。在连续 12 个月的随访期间,用覆盖天数比例(PDC)来衡量依从性。多变量逻辑回归模型用于评估 ET 启动和依从性(PDC ≥ 80%)的相关因素,同时控制协变量。加权 Cox 比例危险模型用于估算ET启动者和非启动者之间以及不同依从性状态下的全因死亡率和乳腺癌相关死亡率的危险比(HRs)和 95% 置信区间(CIs)。结果:在符合条件的女性受益人(n = 55,893)中,43%的人在确诊癌症后 3 个月内开始接受 ET 治疗。在启动者中,77%的患者第一年的 PDC ≥ 80%。患者的人口统计学特征(如年龄较大、种族/民族)和基线医疗服务使用情况(如乳房 X 线照相术)与 ET 的启动和依从性有关。与未开始使用 ET 的患者相比,开始使用 ET 和坚持使用 ET 可降低全因(调整后 HR = 0.62,0.59-0.66;HR = 0.55,0.53-0.59;分别为 0.57,0.50-0.64;HR = 0.41,0.36-0.47;分别为 0.41,0.36-0.47)死亡率和乳腺癌相关死亡率的风险。结论与未接受 ET 治疗的患者相比,接受 ET 并坚持治疗的早期乳腺癌女性患者可获得生存益处。
{"title":"Initiation of Oral Endocrine Therapy and Survival Benefit Among Women with Early-Stage Breast Cancer.","authors":"Jingjing Qian, Bang Truong","doi":"10.1089/jwh.2023.0971","DOIUrl":"10.1089/jwh.2023.0971","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Endocrine therapy (ET) is the cornerstone of systemic treatment for patients with estrogen receptor positive breast cancer, but its uptake and adherence need further improvement. This observational study assessed ET initiation and 1-year adherence and its survival benefit among female Medicare beneficiaries with early-stage breast cancer. <b><i>Materials and Methods:</i></b> This retrospective cohort study analyzed the linked 2011-2019 Surveillance, Epidemiology, and End Results-Medicare data. Female beneficiaries newly diagnosed with hormone receptor positive, stage I-III breast cancer were included. Beneficiaries who initiated tamoxifen, anastrozole, letrozole, or exemestane within 3 months after cancer diagnosis were defined as initiators (<i>n</i> = 24,289), and those who never initiated these treatments were noninitiators (<i>n</i> = 8,899). Adherence was measured using proportion of days covered (PDC) in the continuous 12 months follow-up period. Multivariable logistic regression models were used to assess factors associated with ET initiation and adherence (PDC ≥ 80%), controlling for covariates. Weighted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause and breast cancer related mortality between initiators and noninitiators and by adherence status. <b><i>Results:</i></b> Among eligible female beneficiaries (<i>n</i> = 55,893), 43% initiated ET within 3 months of cancer diagnosis. Among initiators, 77% had PDC ≥ 80% during the first year. Patient's demographics (e.g., older age, race/ethnicity) and baseline health services utilization (e.g., mammography) were associated with ET initiation and adherence. ET initiation and adherence was associated with reduced risk of all-cause (adjusted HR = 0.62, 0.59-0.66; HR = 0.55, 0.53-0.59; respectively) and breast cancer related (adjusted HR = 0.57, 0.50-0.64; HR = 0.41, 0.36-0.47; respectively) mortality compared with noninitiators. <b><i>Conclusion:</i></b> Women with early-stage breast cancer who initiate ET and are adherent to treatment may achieve survival benefits compared with noninitiators.</p>","PeriodicalId":17636,"journal":{"name":"Journal of women's health","volume":" ","pages":"1509-1517"},"PeriodicalIF":3.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Differences in Colonoscopy Indications and Findings: Results from a Large Multicenter Database. 结肠镜检查适应症和结果的性别差异:大型多中心数据库的结果
IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.1089/jwh.2024.0301
Naim Abu-Freha, Revital Guterman, Ruhama Elhayany, Daniel L Cohen, Daniela Munteanu, Vitaly Dizengof, Avraham Yitzhak, Rawi Hazzan, Alexander Fich

Background: Sex-based differences are common among diseases. We aimed to investigate the differences in colonoscopy indications and its findings between males and females. Methods: A large, multi-center, cross-sectional, retrospective study included all colonoscopies performed between 2016 and 2021 in seven endoscopy departments. The indications and findings of the procedures were compared between males and females. Results: A total of 151,411 (52.6%) women and 136,519 (47.4%) men were included, aged 56.54 ± 12.9 years and 56.59 ± 12.7. Cecal intubation was similar (95.6% vs 95.5%, p = 0.251). More females had excellent or good bowel preparation compared to males (71.4% vs 65.6%). Colonoscopy due to abdominal pain, constipation, diarrhea, and anemia was higher in females compared to males (15% vs 9.9%, 3.9% vs 2.2%, and 7.6% vs 4.9%, p < 0.001, respectively), while positive FOBT, rectal bleeding and post-polypectomy surveillance and screening were more common indications among males (9.5% vs 7.8%, 10.7% vs 7.8%, and 10.8% vs 7.1%, respectively). On colonoscopy, males were found to have significantly higher colorectal cancer and polyps (0.5% vs 0.4% and 35.1% vs 24.6%). Polyp detection rates were lower in females across all indications, whereas diverticulosis rates were higher in males. However, a clinically significant difference regarding diverticulosis was observed only in patients with anemia as the indication. Conclusions: Notable differences exist between males and females in terms of the indications and findings on colonoscopy. This highlights the need for identifying the factors contributing to these differences and the developing sex-specific approaches for the diagnosis and management of gastrointestinal diseases.

背景:在各种疾病中,性别差异很常见。我们旨在研究男性和女性在结肠镜检查适应症和检查结果方面的差异。研究方法一项大型、多中心、横断面、回顾性研究纳入了七个内镜科室在 2016 年至 2021 年期间进行的所有结肠镜检查。比较了男性和女性的手术适应症和结果。研究结果共纳入 151411 名女性(52.6%)和 136519 名男性(47.4%),年龄分别为(56.54±12.9)岁和(56.59±12.7)岁。盲肠插管情况相似(95.6% vs 95.5%,p = 0.251)。与男性相比,更多女性(71.4% 对 65.6%)进行了出色或良好的肠道准备。与男性相比,女性因腹痛、便秘、腹泻和贫血而进行结肠镜检查的比例更高(分别为 15% vs 9.9%、3.9% vs 2.2% 和 7.6% vs 4.9%,p < 0.001),而 FOBT 阳性、直肠出血和息肉切除术后监测和筛查是男性更常见的适应症(分别为 9.5% vs 7.8%、10.7% vs 7.8% 和 10.8% vs 7.1%)。在结肠镜检查中,男性患结直肠癌和息肉的比例明显更高(分别为 0.5% 对 0.4% 和 35.1% 对 24.6%)。在所有适应症中,女性的息肉检出率较低,而男性的憩室率较高。然而,只有在以贫血为适应症的患者中才观察到憩室病的临床显著差异。结论:男性和女性在结肠镜检查的适应症和结果方面存在明显差异。这表明有必要找出造成这些差异的因素,并制定针对不同性别的胃肠道疾病诊断和治疗方法。
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Journal of women's health
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