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Systematic Review on Eating Disorder Examination-Questionnaire 6.0 (EDE-Q 6.0): An Agenda for a Test Adaptation in Malaysia 进食障碍考试-问卷6.0 (ed - q 6.0)的系统评价:马来西亚的一个测试适应议程
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-05
Nasehah Mohd Taib, J. H. Abdul Khaiyom, Nor Diana Mohd Mahudin
This study aims to systematically search and review the literature on the Eating Disorder Examination-Questionnaire 6.0 (EDE-Q 6.0) across cultures, in terms of their psychometric properties. Electronic search engines and databases, namely, Scopus, OvidMedline, Google Scholar, and reference tracking were used. The search terms used were eating disorder examination-questionnaire, EDE-Q, psychometrics, reliability, validity, and utility. Studies were included if they conducted psychometric evaluations on the EDE-Q 6.0 (i.e., English version) or adapted EDE-Q 6.0. The PRISMA guideline was also applied in the selection of articles for review. Nineteen papers on EDE-Q, specifically on the sixth version were reviewed. EDE-Q 6.0 has been translated and adapted to various languages and psychometrically evaluated on Japanese, Portuguese, American, Finnish, French, Norwegian, British, Australian, Italian, Iranian, and German populations. EDE-Q 6.0 has recorded good to excellent internal reliability across languages and cultures. Mixtures of findings were found concerning its stability and validity. The factorial structure of EDE-Q 6.0 is very controversial with limited fitness into its initial theoretical four-factor structure. Nonetheless, EDE-Q 6.0 recorded high utility values. The EDE-Q 6.0 is yet to be adapted into Malay for the Malaysian population, hence, calls for further research on its adaptation and its psychometric properties. Keywords: Systematic review; EDE-Q 6.0; test adaptation; test validation
本研究旨在系统检索和回顾不同文化背景下有关饮食失调检查问卷6.0 (ed - q 6.0)的相关文献,分析其心理测量学特征。使用电子搜索引擎和数据库,即Scopus、OvidMedline、谷歌Scholar和文献追踪。使用的搜索词是饮食失调检查问卷,ed -q,心理测量学,信度,效度和效用。对ed - q 6.0(即英文版)或改编版ed - q 6.0进行心理测量评估的研究均被纳入。在选择文章进行审查时也采用了PRISMA指南。本文综述了19篇关于ed - q的论文,特别是关于第六版的论文。EDE-Q 6.0已被翻译并改编成多种语言,并对日本、葡萄牙、美国、芬兰、法国、挪威、英国、澳大利亚、意大利、伊朗和德国人群进行了心理测量学评估。ed - q 6.0记录了良好到优秀的跨语言和文化的内部可靠性。关于其稳定性和有效性,发现了不同的结果。ed - q 6.0的析因结构非常有争议,其初始理论四因素结构的适应度有限。尽管如此,ed - q 6.0记录了较高的效用值。ed - q 6.0还没有被马来西亚人改编成马来语,因此,需要进一步研究它的适应性和它的心理测量特性。关键词:系统评价;EDE-Q 6.0;测试适应;测试验证
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引用次数: 0
A Scoping Review of Assessment Tools and Factors Influencing Spoken Language Development Among Pediatric Cochlear Implant Users 影响儿童人工耳蜗使用者口语发展的评估工具和因素的范围综述
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-01
Deepashini Harithasan, C. Umat
The spoken language development strongly depends on the normally functioning auditory system. For children with severe or profound hearing loss, cochlear implant has become the best solution in improving and promoting spoken language, quality of life, self-esteem and social well-being. Standardized self-report questionnaires are considered as the most widely used and low-cost approach to measure spoken language development among children. We aimed to provide an overview of the questionnaires available for assessing the spoken language development among children with cochlear implant. In addition, factors that may influence the development of good spoken language were also reviewed. A literature search from January 2010 to December 2020 making use of the Science Direct and PubMed databases was conducted. Medical Subject Headings (MeSH) and other key words for the search were (communication OR language) AND cochlear implant AND (children OR pediatric) AND (questionnaire OR survey). Research articles that were identified in the database using the keywords were refined by year. Only original articles were selected. Articles that quoted all the selected key words in the title and abstract; and written in English with full text were included in the review. Twelve instruments were utilized in the methodology of the 10 articles. Only one instrument was specific for spoken language assessment of children with cochlear implant. The age at which a child received an implant, good rehabilitation program and active involvement of parents was found to influence development of good spoken language skills among the cochlear implanted children. Cochlear implants provide deaf children with the opportunity to develop spoken language skills. Longer use of a cochlear implant dramatically affects the amount of spoken language. Rather, it was cochlear implantation at a younger age that served to assists spoken language competence. Keywords: Cochlear implant; communication; factors; spoken language; questionnaire; children
口语的发展很大程度上依赖于听觉系统的正常运作。对于重度或重度听力损失儿童,人工耳蜗已成为改善和促进口语、生活质量、自尊和社会福祉的最佳解决方案。标准化的自我报告问卷被认为是衡量儿童口语发展的最广泛使用和低成本的方法。我们的目的是为评估人工耳蜗儿童口语发展的问卷提供一个概述。此外,还对影响良好口语发展的因素进行了综述。利用Science Direct和PubMed数据库检索2010年1月至2020年12月的文献。医学主题词(MeSH)和其他搜索关键词为(沟通或语言)、人工耳蜗、(儿童或儿科)和(问卷或调查)。使用关键词在数据库中识别的研究文章按年进行细化。只有原创文章被选中。在标题和摘要中引用所有选定关键词的文章;并以英文撰写,并附有全文。在10篇文章的方法中使用了12种工具。只有一种仪器可用于人工耳蜗儿童的口语评估。儿童接受人工耳蜗的年龄、良好的康复计划和父母的积极参与影响了植入人工耳蜗儿童良好口语技能的发展。人工耳蜗为失聪儿童提供了发展口语技能的机会。长时间使用人工耳蜗会显著影响口语量。更确切地说,在年轻时植入人工耳蜗有助于提高口语能力。关键词:人工耳蜗;沟通;因素;口语;问卷调查;孩子们
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引用次数: 0
Chronic Spontaneous Urticaria in Adult Patients: Evaluating the Effect of Loratadine on Weight and Metabolic Syndrome 成人慢性自发性荨麻疹患者:评价氯雷他定对体重和代谢综合征的影响
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-14
Heah SWEE KUAN, A. Jamil, M. Arumugam, Tang MIN MOON, N. Mustafa
Antihistamine is standard chronic spontaneous urticaria (CSU) therapy. Weight gain is a side effect of concern as prolonged high dose therapy is common. We investigated the effects of 12-weeks loratadine therapy on weight, appetite and parameters of metabolic syndrome (MetS). A cohort study was performed involving CSU patients aged ≥18 years. Patients with diseases or on drugs affecting weight or appetite were excluded. CSU was treated according to standard management. Weight, height, waist circumference (WC), body mass index (BMI) and blood pressure (BP), Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI), hunger and satiety questionnaire, fasting blood sugar (FBS) and fasting lipid profile (FLP) were obtained at baseline, week 6 and week 12. Loratadine cumulative dose were determined. Thirteen (33.33 %) males and 26 (66.67 %) females aged 33.00 (12.00) years participated. Median weight was 62.55 (18.30) kg, BMI 24.60 (6.80) kg/m2, 13(33.33%) patients had normal weight, 12 (30.77%) overweight, 11 (28.21%) obese and 3 (7.69%) underweight. Significant weight gain was observed at week 6, 67.56 ± 16.14 kg vs 68.16 ± 16.95 kg, p < 0.05 and 67.56 ± 16.14 kg vs 64.73 ± 14.60 kg, p = 0.04 at week 12. Changes in BMI, WC, BP, FBS and FLP were insignificant. Three patients developed MetS. Hunger and satiety scores were unaffected. Loratadine induced weight gain despite no effects on appetite. Weight should be monitored in patients on long term loratadine therapy. Keywords: Urticaria; loratadine; weight gain; metabolic syndrome; appetite
抗组胺药是标准的慢性自发性荨麻疹(CSU)治疗。由于长期高剂量治疗是常见的,体重增加是令人担忧的副作用。我们研究了12周氯雷他定治疗对体重、食欲和代谢综合征(MetS)参数的影响。一项队列研究纳入年龄≥18岁的CSU患者。排除患有疾病或正在服用影响体重或食欲的药物的患者。颅内伤按规范处理。在基线、第6周和第12周获得体重、身高、腰围(WC)、体重指数(BMI)和血压(BP)、荨麻疹活动评分7 (UAS7)、皮肤病生活质量指数(DLQI)、饥饿和饱腹感问卷、空腹血糖(FBS)和空腹血脂(FLP)。测定氯雷他定累积剂量。年龄33.00(12.00)岁,男性13例(33.33%),女性26例(66.67%)。中位体重为62.55 (18.30)kg, BMI为24.60 (6.80)kg/m2,体重正常13例(33.33%),超重12例(30.77%),肥胖11例(28.21%),体重不足3例(7.69%)。第6周体重显著增加,67.56±16.14 kg比68.16±16.95 kg, p < 0.05;第12周体重显著增加,67.56±16.14 kg比64.73±14.60 kg, p = 0.04。BMI、WC、BP、FBS、FLP变化不显著。3名患者出现了MetS。饥饿和饱腹感得分不受影响。氯雷他定导致体重增加,但对食欲没有影响。长期服用氯雷他定的患者应监测体重。关键词:荨麻疹;氯雷他定;体重增加;代谢综合征;食欲
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引用次数: 0
A Scoping Review on Knowledge, Attitude and Perception of the Public on Smoking Ban Policy by the Ministry of Health Malaysia 马来西亚卫生部关于公众对禁烟政策的知识、态度和看法的范围审查
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-07
J. Bakar, Syed Ismail Syed Mohamad, Hamidah Yusof, Ida Zaliza Zainol Abidin
Malaysia is one of the countries that have signed the WHO Framework Convention on Tobacco Control (FCTC). The WHO FCTC is a form of evidence-based agreement that recognises the right of all people to attain the highest standard of health. Policies established by the government were in line with the WHO requirements to gazette the nationwide smoking ban so that enforcement measures can be taken to control smoking activities in public places. The purpose of this scoping review is to give an overview of the extent of knowledge, attitude, and the perception of the public on smoking ban policies implemented in Malaysia. The keyword search strategy was as follows: smoking AND policy AND Malaysia AND (knowledge OR attitude OR perception) for publications between the year 2015-2021, conducted through several databases including Medline (search results of 5 publications), Web of Science (search results of 9 publications) and Scopus (search results of 19 publications). A total of 12 articles were considered relevant to answer the research objectives. We found that the level of knowledge, attitude, and perception of the public towards the smoking ban policy in Malaysia was still defective and inadequate. Therefore, it is hoped that the results of this multifactorial relationship study could cultivate governance in administration and governmental policies to imbue competency and efficiency. Keywords: Governance; policy and implementation; government; tobacco; Malaysia
马来西亚是签署《世界卫生组织烟草控制框架公约》的国家之一。《世界卫生组织烟草控制框架公约》是一种以证据为基础的协议,承认所有人都有权达到最高标准的健康。政府制定的政策符合世界卫生组织发布全国禁烟令的要求,以便采取执法措施控制公共场所的吸烟活动。这项范围审查的目的是概述公众对马来西亚实施的禁烟政策的知识、态度和看法的程度。关键词搜索策略为:吸烟和政策以及马来西亚和(知识或态度或感知),针对2015-2021年间的出版物,通过Medline(5份出版物的搜索结果)、Web of Science(9份出版物的搜索结果)和Scopus(19份出版物的搜索结果)等多个数据库进行。共有12篇文章被认为与研究目标相关。我们发现,公众对马来西亚禁烟政策的知识、态度和认知水平仍然存在缺陷和不足。因此,希望本多因子关系研究的结果,能够培养行政治理和政府政策,以灌输胜任力和效率。关键词:公司治理;政策和实施;政府;烟草;马来西亚
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引用次数: 0
A Case Study on Sibling Relational Problem: Its Clinical Significance in Managing A Dyslexic Adolescent with Mild Depressive Disorder 兄弟姐妹关系问题的个案研究:对一名患有轻度抑郁障碍的阅读障碍青少年的临床意义
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-04
A. Thiagarajan, N. Muhammad
The purpose of this case study was to see the impacts of managing sibling relational problem on mild depressive disorder. This approach was applied on a 15-year-old girl, who has dyslexia. She was found to have mild depression for one year that was precipitated by her poor relationship with her younger sibling. The intervention used in managing this case was adapted from the Siblings Are Special Module, a special programme that helps to alleviate anger and frustration that siblings had on each other. These 5 session interventions also included leisure activities that helped them to overcome their ongoing conflicts and were conducted over 3 months period. Parents were involved in the last 2 sessions in order to promote positive parenting. She showed a marked improvement in her psychological wellbeing and family relationship especially with her siblings at the end of the intervention. In conclusion, the intervention used to improve sibling relationship has shown to be effective in improving the mental health of the adolescents. Keywords: Adolescent; depressive disorder; siblings
本案例研究的目的是观察处理兄弟姐妹关系问题对轻度抑郁障碍的影响。这一方法应用于一名患有阅读障碍的15岁女孩。她被发现患有轻度抑郁症达一年之久,这是由于她与弟弟妹妹关系不佳。用于处理这起案件的干预措施改编自“兄弟姐妹是特别模块”,这是一个有助于缓解兄弟姐妹之间的愤怒和沮丧情绪的特别计划。这5次会议的干预措施还包括帮助他们克服持续冲突的休闲活动,为期3个月。家长们参与了最后两次会议,以促进积极的育儿方式。在干预结束时,她表现出心理健康和家庭关系的显著改善,尤其是与兄弟姐妹的关系。总之,用于改善兄弟姐妹关系的干预措施已被证明对改善青少年的心理健康是有效的。关键词:青少年;抑郁障碍;兄弟姐妹
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引用次数: 0
Association between Knowledge, Attitude, and Practice of Nutrition and Food Labels among Selected Higher Educational Institution Students in Klang Valley 巴生谷部分高校学生营养知识、态度和实践与食品标签的关系
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-09
Loo SHI YEE, Anis Wahida Md Nazri, Nur Eizzati Farhani Rosle, Kok PEI YEE, Phang CHIN YI, Lee YI YI, Vanitha Mariappan, S. Krishnasamy
Nutrition information on food labels guides consumers to purchase healthier food choices. Besides nutrition information, other factors influence a purchase. This study aims to determine the association between the knowledge, attitude, and practice (KAP) among tertiary students on nutrition and food labels. In this cross-sectional study, a total of 190 students from three tertiary institutions within Klang Valley completed an online survey. Self-administered questionnaires on sociodemographic profiles and KAP questions, available in Malay and English, were distributed. Association between KAP was determined using Spearman's Rho test, while multiple linear regression was used to assess predictors of KAP scores. Mean body mass index (BMI) of the respondents were 20.8 kg/m2. The total mean score for knowledge on food labels was 8.93, followed by attitude and practice with 3.86 and 3.11, respectively. There was a significant correlation between attitude and practice (p<0.005). Nutrient and total calorie information on food labels influenced purchases, with 56.3% of respondents reported looking at the total calorie content, followed by 55.7% and 49.5% checking on sugar and fats, respectively. In addition, other factors such as expiry date (60.9%) and price (59.9%) also influenced purchases. Overall, respondents have a positive attitude on food selection, but male respondents have better knowledge levels than females. However, female respondents interpret food labelling effectively compared to male respondents. Despite having good knowledge and attitude towards nutrition, respondents were still making poor choices. A more extensive range of healthier food options and targeted healthy eating campaigns may empower students to choose more nutritious foods. Keywords: Knowledge; attitude; practices; food labels; tertiary students
食品标签上的营养信息指导消费者购买更健康的食品。除了营养信息,其他因素也会影响购买。本研究旨在探讨大专学生对营养与食品标签之认知、态度与行为(KAP)之关系。在这项横断面研究中,来自巴生谷三所高等院校的190名学生完成了一项在线调查。分发了马来文和英文的关于社会人口概况和KAP问题的自填调查表。使用Spearman's Rho检验确定KAP之间的相关性,并使用多元线性回归评估KAP评分的预测因子。被调查者的平均身体质量指数(BMI)为20.8 kg/m2。食品标签知识的总平均得分为8.93分,其次是态度和做法,分别为3.86分和3.11分。态度与行为有显著相关(p<0.005)。食品标签上的营养和总卡路里信息影响了购买行为,56.3%的受访者表示会查看总卡路里含量,其次是55.7%和49.5%的受访者会查看糖和脂肪。此外,其他因素,如到期日(60.9%)和价格(59.9%)也影响购买。总体而言,受访者对食物选择持积极态度,但男性受访者的知识水平高于女性。然而,与男性受访者相比,女性受访者对食品标签的理解更有效。尽管受访者对营养有良好的知识和态度,但仍然做出了糟糕的选择。更广泛的健康食品选择和有针对性的健康饮食活动可能使学生能够选择更有营养的食物。关键词:知识;态度;实践;食品标签;高等教育的学生
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引用次数: 0
Ayres Sensory Integration ® Implementation in Malaysian Occupational Therapists: Challenges and Limitations Ayres感觉统合®在马来西亚职业治疗师的实施:挑战和限制
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-12
Farah Samsu Rahman, Masne Kadar, D. Harun
One of the most popular interventions provided by occupational therapists for pediatric clients is Ayres Sensory Integration® (ASI). Strict fidelity measures consisting of procedural and structural elements must be adhered to when using it. These fidelity measures distinguish Ayres Sensory Integration® from other sensory-based interventions. This study involved the development of a survey instrument and outlined the challenges that Malaysian occupational therapists face when using Ayres sensory integration® (ASI). The questionnaire development involved the processes of assessing its validity and reliability. A total of 161 occupational therapists working in various healthcare settings responded to the survey by answering a self-administered questionnaire. The results identified eight themes or issues: (1) Inadequate Training, (2) Resource Issues, (3) Physical Constraints, (4) Time Constraints, (5) Limited Information/ Support Provided By Family, (6) Limited Support From Management, (7) Limited Information/Support Provided By Suppliers, and (8) Issues in Implementing Evidence-Based Practice. Identifying the challenges of implementing ASI is an important aspect of improving occupational therapy assessments and interventions, which would establish the effectiveness of the interventions provided. Keywords: Ayres sensory integration; occupational therapy intervention; fidelity measures; sensory processing issues
职业治疗师为儿科客户提供的最受欢迎的干预措施之一是Ayres Sensory Integration®(ASI)。使用时必须遵守由程序和结构元素组成的严格保真度测量。这些保真度测量将Ayres Sensory Integration®与其他基于感官的干预措施区分开来。这项研究涉及一种调查工具的开发,并概述了马来西亚职业治疗师在使用Ayres感觉统合®(ASI)时面临的挑战。调查表的编制涉及评估其有效性和可靠性的过程。共有161名在不同医疗机构工作的职业治疗师回答了一份自我管理的问卷。研究结果确定了八个主题或问题:(1)培训不足,(2)资源问题,(3)身体限制,(4)时间限制,(5)家庭提供的信息/支持有限,(6)管理层提供的支持有限。识别实施ASI的挑战是改进职业治疗评估和干预措施的一个重要方面,这将确定所提供干预措施的有效性。关键词:艾尔斯感觉统合;职业治疗干预;保真度度量;感官处理问题
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引用次数: 0
Prevalence of Turkish Parent Refusal and Hesitance Rate and Its Associated Factors in Childhood Vaccination 土耳其儿童疫苗接种中父母拒绝和犹豫率的患病率及其相关因素
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-02
Ali Özlem, Arzu Özlem, M. Koçak, N. Mehmet
The Rejection of childhood vaccination is still a major issue in many countries. The aim of the study was to assess prevalence of Turkish parent refusal and hesitance rate and its associated factors in Childhood vaccination. A crosssectional study was carried out at the General Pediatric Poly Clinic of Ankara Keçören Training and Research Hospital from January – to April 2020. Data was collected using a questionnaire via face to face interviews with parents. We included parents who have 6 months to 7 years old children, who visited the clinic during the study period and who accepted to join the study. A total of 809 mothers and 132 fathers participated in the survey. Among the parents, 1.2% of them refused the vaccination of their children and 4.8 % of them had incomplete vaccination of their children. More than half (67.4%) of the parents have a high level of knowledge about vaccines. knowledge level was statistically significantly different based on the participant’s occupation, income, education background and father’s age (P <0.05). A majority (72.2%) of the participants had good attitudes toward childhood vaccination, there is no statistically significance based on their occupation, age, income and education background (P > 0.05). Parents with one child had bad attitudes towards vaccines (35.4%). Keywords: Childhood vaccine; vaccine hesitance; vaccine rejection
拒绝儿童接种疫苗仍然是许多国家的一个主要问题。本研究的目的是评估土耳其父母拒绝和犹豫率的患病率及其在儿童疫苗接种中的相关因素。2020年1月至4月,在安卡拉科伦培训研究医院的综合儿科保利诊所进行了一项横断面研究。数据是通过与家长面对面访谈的方式使用问卷收集的。我们包括有6个月至7岁孩子的父母,他们在研究期间访问了诊所,并接受了参与研究。共有809名母亲和132名父亲参加了调查。在家长中,1.2%的家长拒绝为孩子接种疫苗,4.8%的家长为孩子接种了不完整的疫苗。超过一半(67.4%)的父母对疫苗有很高的了解。根据参与者的职业、收入、教育背景和父亲的年龄,知识水平差异有统计学意义(P 0.05)。有一个孩子的父母对疫苗的态度不好(35.4%)。关键词:儿童疫苗;疫苗犹豫;疫苗排斥
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引用次数: 1
Impact of COVID-19 Lockdown on Physical Activity and Mental Health among Undergraduate Students COVID-19封锁对大学生身体活动和心理健康的影响
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-06
Sheng Hui Kioh, Aun QUIN LIM, Jin YIE CHONG, Zhi KEAT CHAN
With the sudden change of environment and limited studies on the effects of COVID-19 lockdown among university students, this study therefore aims to examine the effects of COVID-19 lockdown on physical activity level and mental health among university students in Malaysia. This is a cross-sectional study involving university students studying in Klang Valley, Malaysia. Demographics information, living status during COVID-19, physical activity level and mental health status were obtained through online questionnaire via Microsoft forms. Paired T-test was used to compare the effect of physical activity level and mental health status during COVID-19 lockdown. Data on falls was available for 383 participants with 254 (66.3 %) women and 129 (33.7%) men. Overall, the metabolic equivalent task (MET) of vigorous, moderate, mild, and total MET has decreased during COVID-19 lockdown as compared to before COVID-19 lockdown. Approximately an increment of 6% of participants reported having depression and anxiety during COVID-19 lockdown. In conclusion, significant impact on physical activity level and mental health was found in our study. Our study findings could therefore assist educational institutions and policymakers in forming strategies to improve student’s overall health, yet further longitudinal studies should be performed to examine the long-term effects of COVID-19 lockdown. Keywords: Pandemic; students; sedentary; depression; anxiety
鉴于环境的突然变化和对新冠肺炎封锁对大学生影响的有限研究,本研究旨在研究新冠肺炎封锁对马来西亚大学生身体活动水平和心理健康的影响。这是一项涉及马来西亚巴生谷大学生的横断面研究。通过微软表格,通过在线问卷获得人口统计信息、新冠肺炎期间的生活状况、体力活动水平和心理健康状况。配对T检验用于比较新冠肺炎封锁期间身体活动水平和心理健康状况的影响。383名参与者的跌倒数据可用,其中254名(66.3%)为女性,129名(33.7%)为男性。总体而言,与新冠肺炎封锁前相比,新冠肺炎封锁期间,剧烈、中度、轻度和总代谢当量任务(MET)有所下降。约有6%的参与者报告在新冠肺炎封锁期间患有抑郁症和焦虑症。总之,在我们的研究中发现了对身体活动水平和心理健康的显著影响。因此,我们的研究结果可以帮助教育机构和政策制定者制定改善学生整体健康的策略,但还应进行进一步的纵向研究,以检查新冠肺炎封锁的长期影响。关键词:流行病;学生;久坐不动的抑郁症焦虑
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引用次数: 0
Potentials of Immunonutrition in Wound Healing: A Review 免疫营养在伤口愈合中的潜力:综述
Pub Date : 2022-07-01 DOI: 10.17576/jskm-2022-2002-03
Yap Wei Boon, Nur Farhana Azizan, Elynna Azura Hasnol, Kavipriya Krishnan, Sivanesan Rajeswaran, Jia YIN CHOW, Noraihan Irwan, Pavitra Indrajoth, Pramila Mani MARAN, MUNIRAH ISMAIL, M. Ismail
A delayed wound healing process can lead to detrimental complications in chronic wound patients such as tissue necrosis and systemic infections. Application of immunonutrition (IN) in experimental animal models and chronic wound patients has shown promising and improved wound healing processes. IN restores the supply of essential nutrients that are critical for cell growth and tissue repair in the wounded subjects. Several commonly found nutrients in IN formulations include polyunsaturated fatty acids (PUFAs), essential amino acids, trace elements such as zinc and vitamins. Recently, some studies suggested the use of traditionally used herbs like curcumin in IN recipes due to its efficient wound healing properties. The roles and functions of IN in wound healing encompass recruitment of white blood cells, platelets and fibroblasts into the wounded area during the coagulation and inflammation phases, enhancement of fibroblast proliferation, collagen synthesis and neovascularization in the proliferation phase; and lastly, regulation of tissue re-epithelization for wound closure and recovery. In this review, the roles and functions of individual nutrients were deliberately discussed alongside their mechanisms of action in wound healing. This aims to provide a more holistic insight into the potentials of those nutrients when used as part of IN for major wound patients. Despite its remarkable effects in wound healing, several criteria should be considered in an IN formulation: the type and severity of wounds, administration timing and mode of administration, and concoction of immune-boosting nutrients in order to ensure the optimal wound healing effects. Keywords: Wound healing; immunonutrition; PUFAs; amino acids; vitamins
伤口愈合过程延迟会导致慢性伤口患者出现有害并发症,如组织坏死和全身感染。免疫营养(IN)在实验动物模型和慢性伤口患者中的应用显示出良好的伤口愈合过程。IN恢复了对受伤受试者的细胞生长和组织修复至关重要的基本营养素的供应。in配方中常见的几种营养素包括多不饱和脂肪酸(PUFA)、必需氨基酸、锌和维生素等微量元素。最近,一些研究表明,由于姜黄素具有有效的伤口愈合特性,因此在in配方中使用姜黄素等传统草药。IN在伤口愈合中的作用和功能包括在凝血和炎症阶段将白细胞、血小板和成纤维细胞募集到受伤区域,在增殖阶段增强成纤维细胞增殖、胶原合成和新生血管形成;最后,组织再上皮化对伤口闭合和恢复的调节。在这篇综述中,专门讨论了个体营养素的作用和功能,以及它们在伤口愈合中的作用机制。这旨在为这些营养素作为主要创伤患者IN的一部分时的潜力提供更全面的见解。尽管in在伤口愈合方面有显著效果,但在配方中应考虑几个标准:伤口的类型和严重程度、给药时间和给药方式,以及免疫增强营养素的配制,以确保最佳的伤口愈合效果。关键词:伤口愈合;免疫营养;PUFA;氨基酸;维生素
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Jurnal Sains Kesihatan Malaysia
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