Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.8
Leli Hesti Indriyati, S. GeaPandhita, N. Anis, A. Suraya
Ischemic Heart Disease (IHD) is one of the leading causes of morbidity and mortality in many countries, including Indonesia. Therefore, cardiovascular risk-prediction models are required in clinical practice for early detection in high-risk populations, including the worker population. This study intends to develop a predictive risk measure for early detection of IHD incidences among employees in Jakarta, Indonesia. Source of data was the database of 4,100 medical check-up (MCU) results of employees and entrepreneurs in Jakarta and surrounding areas in January to October 2019. Multivariate analysis showed that being aged >40 years (p=0.000; OR=5.329 (95% CI 2.621-10.833)), having a history of dyspnea (p=0.000; OR=5.699 (95% CI 2.524-12.871)), smoking (p=0.048; OR=2.007 (95% CI 1.924-4.359)) and HDL<50 mg/dL (p=0.049; OR=1.811 (95% CI 1.099-3.281)) were all good predictors to detect IHD in the worker population. The combination of these predictors results with a cut-off point of 2.5, showed accuracy (79.2% sensitivity and 66.3% specificity). Workers who have a score >2.5 are at high risk of developing IHD in the future. This scoring system can be used by workers or companies to take early preventive measures.
缺血性心脏病(IHD)是包括印度尼西亚在内的许多国家发病率和死亡率的主要原因之一。因此，在临床实践中需要建立心血管风险预测模型，以便在包括工人在内的高危人群中进行早期发现。本研究旨在开发一种预测风险措施，以早期发现印度尼西亚雅加达的员工中IHD的发病率。数据来源是2019年1月至10月雅加达及周边地区员工和企业家的4100次体检结果数据库。多因素分析显示，年龄>40岁(p=0.000;OR=5.329 (95% CI 2.621-10.833))，有呼吸困难史(p=0.000;OR=5.699 (95% CI 2.524-12.871))，吸烟(p=0.048;OR=2.007 (95% CI 1.924-4.359))和HDL2.5在未来发展为IHD的风险很高。这个计分系统可以被工人或公司用来采取早期预防措施。
{"title":"Predictive measure for Ischemic Heart Disease among Workers in Jakarta, Indonesia","authors":"Leli Hesti Indriyati, S. GeaPandhita, N. Anis, A. Suraya","doi":"10.21776/ub.jkb.2021.031.04.8","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.8","url":null,"abstract":"Ischemic Heart Disease (IHD) is one of the leading causes of morbidity and mortality in many countries, including Indonesia. Therefore, cardiovascular risk-prediction models are required in clinical practice for early detection in high-risk populations, including the worker population. This study intends to develop a predictive risk measure for early detection of IHD incidences among employees in Jakarta, Indonesia. Source of data was the database of 4,100 medical check-up (MCU) results of employees and entrepreneurs in Jakarta and surrounding areas in January to October 2019. Multivariate analysis showed that being aged >40 years (p=0.000; OR=5.329 (95% CI 2.621-10.833)), having a history of dyspnea (p=0.000; OR=5.699 (95% CI 2.524-12.871)), smoking (p=0.048; OR=2.007 (95% CI 1.924-4.359)) and HDL<50 mg/dL (p=0.049; OR=1.811 (95% CI 1.099-3.281)) were all good predictors to detect IHD in the worker population. The combination of these predictors results with a cut-off point of 2.5, showed accuracy (79.2% sensitivity and 66.3% specificity). Workers who have a score >2.5 are at high risk of developing IHD in the future. This scoring system can be used by workers or companies to take early preventive measures.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80535160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.9
Widya Trianita Suwatri, D. Hanafy, Sugisman Sugisman
The benefit of coronary artery bypass graft (CABG) for coronary artery disease (CAD) with Ejection Fraction (EF) 30% and ischemic burden (IB) 10% is still debatable. The objective of this study is to analyze mortality and morbidity in patients with EF 30% and ischemic burden 10% undergoing OPCAB compared to traditional CABG (TCABG). The retrospective analytic cohort study was performed using data from January 2015–November 2018 at National Cardiovascular Center Harapan Kita Jakarta, Indonesia. 109 patients were included. 35 patients undergoing OPCAB and 74 patients undergoing TCABG. The primary outcomes were mortality rate, morbidity rate, and length of stay. Arrhythmia is statistically lower in OPCAB compared to TCABG (8.6% vs 39.2%; p=0.001). Kidney injury is statistically lower in OPCAB (8.6% vs 27.0 %; p=0.027). Stroke is statistically lower in OPCAB (1.0 % vs 17.6%; p=0,032). There is no significant difference between OPCAB and TCABG in mortality, 5.7% vs 16.2%, (RR=3.20; CI 95%=0.67–15.12; p= 0.126). There was a statistically significant difference in the occurrence of postoperative morbidity in CAD patients with EF <30% and IB<10% who underwent OPCAB surgery compared with patients who underwent TCABG. Mortality that occurred after OPCAB procedure was lower in CAD patients with EF < 30% and IB<10% compared to TCABG although the statistical difference was not significant. Therefore, patients with this condition are more advisable to undergo OPCAB.
冠状动脉旁路移植术(CABG)对射血分数(EF) 30%和缺血负荷(IB) 10%的冠状动脉疾病(CAD)的益处仍有争议。本研究的目的是分析OPCAB与传统CABG (TCABG)相比，EF为30%，缺血负担为10%的患者的死亡率和发病率。回顾性分析队列研究使用2015年1月至2018年11月在印度尼西亚雅加达Harapan Kita National Cardiovascular Center进行的数据，共纳入109例患者。35例接受OPCAB, 74例接受TCABG。主要结局是死亡率、发病率和住院时间。与TCABG相比，OPCAB组的心律失常在统计学上更低(8.6% vs 39.2%;p = 0.001)。OPCAB组肾损伤发生率较低(8.6% vs 27.0%;p = 0.027)。OPCAB组卒中发生率较低(1.0% vs 17.6%;p = 0032)。OPCAB和TCABG的死亡率无显著差异，分别为5.7%和16.2%，(RR=3.20;CI 95% = 0.67 - -15.12;p = 0.126)。EF <30%、IB<10%的CAD患者行OPCAB手术与行TCABG患者术后发病率比较，差异有统计学意义。与TCABG相比，EF < 30%和IB<10%的CAD患者OPCAB手术后的死亡率较低，但统计学差异无显著性。因此，这种情况的患者更建议进行OPCAB。
{"title":"Cardiovascular Outcomes in High-Risk Patients Undergoing OPCAB Surgery Compared to Traditional CABG","authors":"Widya Trianita Suwatri, D. Hanafy, Sugisman Sugisman","doi":"10.21776/ub.jkb.2021.031.04.9","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.9","url":null,"abstract":"The benefit of coronary artery bypass graft (CABG) for coronary artery disease (CAD) with Ejection Fraction (EF) 30% and ischemic burden (IB) 10% is still debatable. The objective of this study is to analyze mortality and morbidity in patients with EF 30% and ischemic burden 10% undergoing OPCAB compared to traditional CABG (TCABG). The retrospective analytic cohort study was performed using data from January 2015–November 2018 at National Cardiovascular Center Harapan Kita Jakarta, Indonesia. 109 patients were included. 35 patients undergoing OPCAB and 74 patients undergoing TCABG. The primary outcomes were mortality rate, morbidity rate, and length of stay. Arrhythmia is statistically lower in OPCAB compared to TCABG (8.6% vs 39.2%; p=0.001). Kidney injury is statistically lower in OPCAB (8.6% vs 27.0 %; p=0.027). Stroke is statistically lower in OPCAB (1.0 % vs 17.6%; p=0,032). There is no significant difference between OPCAB and TCABG in mortality, 5.7% vs 16.2%, (RR=3.20; CI 95%=0.67–15.12; p= 0.126). There was a statistically significant difference in the occurrence of postoperative morbidity in CAD patients with EF <30% and IB<10% who underwent OPCAB surgery compared with patients who underwent TCABG. Mortality that occurred after OPCAB procedure was lower in CAD patients with EF < 30% and IB<10% compared to TCABG although the statistical difference was not significant. Therefore, patients with this condition are more advisable to undergo OPCAB.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77620599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.11
Siska Puji Lestari, T. A. Wihastuti, D. D. S. L. Ismail
Diabetes mellitus is a health problem that will affect the health status of patients. Motivational interviewing a counseling technique focusing on clients and it is designed for helping individuals explore and accomplish ambivalence in behavior. This systematic review aimed at describing effectiveness motivationaI interviewing on self-management of diabetes mellitus type 2 patients. There are 1359 articles of 526 ScienceDirect articles, 422 ProQuest, 290 PubMed, and 121 Ebsco articles. The systematic review method began by identifying 20 articles from four electronic databases for previous studies that were published during 2011-2021. The results of the systematic review obtained that motivational interviewing can provide improved self-management and control blood glucose DM type 2 patients. The conclusion motivational interviewing can affect the patient's self-management especially on blood glucose profile, dietary compliance, quality of life, self-efficacy, HbA1c levels of DM type 2 patients.
{"title":"Effectiveness of Motivational Interviewing on Self-Management of Type 2 Diabetes Mellitus Patients: A Systematic Review","authors":"Siska Puji Lestari, T. A. Wihastuti, D. D. S. L. Ismail","doi":"10.21776/ub.jkb.2021.031.04.11","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.11","url":null,"abstract":"Diabetes mellitus is a health problem that will affect the health status of patients. Motivational interviewing a counseling technique focusing on clients and it is designed for helping individuals explore and accomplish ambivalence in behavior. This systematic review aimed at describing effectiveness motivationaI interviewing on self-management of diabetes mellitus type 2 patients. There are 1359 articles of 526 ScienceDirect articles, 422 ProQuest, 290 PubMed, and 121 Ebsco articles. The systematic review method began by identifying 20 articles from four electronic databases for previous studies that were published during 2011-2021. The results of the systematic review obtained that motivational interviewing can provide improved self-management and control blood glucose DM type 2 patients. The conclusion motivational interviewing can affect the patient's self-management especially on blood glucose profile, dietary compliance, quality of life, self-efficacy, HbA1c levels of DM type 2 patients.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74213424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.2
Idsap Peramiarti
Diarrhea is defecation with a frequency more often than usual (three times or more) a day (10 mL/kg/day) with a soft or liquid consistency, even in the form of water alone. Pathogenic bacteria, such as Escherichia coli, Salmonella typhimurium, and Shigella sp., play a role in many cases, to which antibiotics are prescribed as the first-line therapy. However, since antibiotic resistance cases are often found, preventive therapies are needed, such as consuming yogurt, which is produced through a fermentation process by lactic acid bacteria (LAB). This research aimed to determine the activity of lactic acid bacteria (Liactobacillus bulgaricus and Streptococcus thermophilus) in yogurt in inhibiting the growth of the pathogenic bacteria E. coli, S. typhimurium, and Shigella sp. The research applied in vitro with the liquid dilution test method and the true experimental design research method with post-test-only and control group design. The design was used to see the inhibitory effect of yogurt LAB on the growth of E. coli, S. typhimurium, and Shigell sp. to compare the effect of several different yogurt concentrations, namely 20%, 40%, 60%, and 80%. The results of the Least Significance Different analysis showed that there was a significant difference between yogurt with a concentration of 0% and that with various concentrations in inhibiting the growth of E. coli, S. typhimurium, and Shigella sp. with a p-value of <0.05. Whereas, there was no significant difference in the various concentrations of yogurt in inhibiting the growth of the three kinds of bacteria with a p-value of > 0.05.
{"title":"Lactic Acid Bacteria (Lactobacillus bulgaricus and Streptococcus thermophillus) in Yogurt Inhibit the Growth of Escherichia coli, Salmonella typhimurium, and Shigella sp. In Vitro","authors":"Idsap Peramiarti","doi":"10.21776/ub.jkb.2021.031.04.2","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.2","url":null,"abstract":"Diarrhea is defecation with a frequency more often than usual (three times or more) a day (10 mL/kg/day) with a soft or liquid consistency, even in the form of water alone. Pathogenic bacteria, such as Escherichia coli, Salmonella typhimurium, and Shigella sp., play a role in many cases, to which antibiotics are prescribed as the first-line therapy. However, since antibiotic resistance cases are often found, preventive therapies are needed, such as consuming yogurt, which is produced through a fermentation process by lactic acid bacteria (LAB). This research aimed to determine the activity of lactic acid bacteria (Liactobacillus bulgaricus and Streptococcus thermophilus) in yogurt in inhibiting the growth of the pathogenic bacteria E. coli, S. typhimurium, and Shigella sp. The research applied in vitro with the liquid dilution test method and the true experimental design research method with post-test-only and control group design. The design was used to see the inhibitory effect of yogurt LAB on the growth of E. coli, S. typhimurium, and Shigell sp. to compare the effect of several different yogurt concentrations, namely 20%, 40%, 60%, and 80%. The results of the Least Significance Different analysis showed that there was a significant difference between yogurt with a concentration of 0% and that with various concentrations in inhibiting the growth of E. coli, S. typhimurium, and Shigella sp. with a p-value of <0.05. Whereas, there was no significant difference in the various concentrations of yogurt in inhibiting the growth of the three kinds of bacteria with a p-value of > 0.05. ","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79962360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.13
Farhad Bal'afif, D. W. Wardhana, T. A. Nazwar, Novia Ayuning Nastiti
Ventriculoperitoneal (VP) Shunt is a commonly performed surgical procedure and offers a good result in the treatment of hydrocephalus. In general, 25% of the complication rate of this surgical procedure is abdominal complications. Anal extrusion of a peritoneal catheter is a rare complication ranging from 0.1 to 0.7% of all shunt surgeries. This study presents a rare case of anal extrusion of ventriculoperitoneal shunt in a 1-year-old female child who was asymptomatic. The physical examination revealed swelling and redness along the shunt tract on the retro auricular region, soft abdomen, and no catheter was observed in the anal. This study found several contributing factors affecting the complications in the anal extrusion of a peritoneal catheter, that are thin bowel wall in children and sharp tip and stiff end of VP shunt. The shunt should be disconnected from the abdominal wall, and the lower end should be removed through the rectum by colonoscopy or sigmoidoscopy/proctoscopy or by applying gentle traction on the protruding tube. This study concludes that due to potentially life-threatening consequences and case rarity, thorough anamnesis, physical examination, and objective investigation are needed to determine the appropriate management for anal extrusion of ventriculoperitoneal shunt.
{"title":"Anal Extrusion of Ventriculoperitoneal Shunt: A Case Report and Review of Literature","authors":"Farhad Bal'afif, D. W. Wardhana, T. A. Nazwar, Novia Ayuning Nastiti","doi":"10.21776/ub.jkb.2021.031.04.13","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.13","url":null,"abstract":"Ventriculoperitoneal (VP) Shunt is a commonly performed surgical procedure and offers a good result in the treatment of hydrocephalus. In general, 25% of the complication rate of this surgical procedure is abdominal complications. Anal extrusion of a peritoneal catheter is a rare complication ranging from 0.1 to 0.7% of all shunt surgeries. This study presents a rare case of anal extrusion of ventriculoperitoneal shunt in a 1-year-old female child who was asymptomatic. The physical examination revealed swelling and redness along the shunt tract on the retro auricular region, soft abdomen, and no catheter was observed in the anal. This study found several contributing factors affecting the complications in the anal extrusion of a peritoneal catheter, that are thin bowel wall in children and sharp tip and stiff end of VP shunt. The shunt should be disconnected from the abdominal wall, and the lower end should be removed through the rectum by colonoscopy or sigmoidoscopy/proctoscopy or by applying gentle traction on the protruding tube. This study concludes that due to potentially life-threatening consequences and case rarity, thorough anamnesis, physical examination, and objective investigation are needed to determine the appropriate management for anal extrusion of ventriculoperitoneal shunt. ","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77424166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.3
Ratna Adelia Pravitasari
Hepatic encephalopathy (HE) is brain dysfunction manifested as a broad spectrum of neuropsychiatric abnormalities caused by hepatic insufficiency or portosystemic shunting due to portal hypertension. Portal hypertension in liver cirrhosis also causes ascites, as the most common clinical manifestation. Further, immune dysfunction, one of which is decreased total lymphocyte count (TLC), happens at liver cirrhosis, which triggers the systemic inflammatory response. This systemic inflammatory response plays a role in HE. Objective of this study is to know the correlation between ascites and TLC with occurence of HE in liver cirrhosis patient. This study was conducted by retrospective cohort design in Saiful Anwar Hospital. Determination of sample amount at this study used total sampling method. Hepatic encephalopathy diagnosis was based on West Haven Criteria. Ascites was determined by physical examination and/or abdominal ultasonography. Total lymphocyte count data was taken from medical record, with complete blood count examination used XS-800i hematology analyzer machine. Data were analyzed using a logistic regression test, with p<0.05 was considered significant and Confidence Interval (CI) 95%. Seventy-eight liver cirrhosis patients were observed using a retrospective cohort method regarding the HE occurrence, and physical examination for ascites and laboratory examination were performed. The statistical analysis result of the correlation between ascites and HE is significant with an odds ratio of 5.108 and CI of 1.36-19.25. On the other hand, TLC has no significant correlation with the occurrence of HE. Based on this analysis result, it is concluded that ascites has a correlation with HE, but TLC does not.
{"title":"Correlation between Ascites and Total Lymphocyte Count with Occurrence of Hepatic Encephalopathy in Liver Cirrhosis Patients","authors":"Ratna Adelia Pravitasari","doi":"10.21776/ub.jkb.2021.031.04.3","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.3","url":null,"abstract":"Hepatic encephalopathy (HE) is brain dysfunction manifested as a broad spectrum of neuropsychiatric abnormalities caused by hepatic insufficiency or portosystemic shunting due to portal hypertension. Portal hypertension in liver cirrhosis also causes ascites, as the most common clinical manifestation. Further, immune dysfunction, one of which is decreased total lymphocyte count (TLC), happens at liver cirrhosis, which triggers the systemic inflammatory response. This systemic inflammatory response plays a role in HE. Objective of this study is to know the correlation between ascites and TLC with occurence of HE in liver cirrhosis patient. This study was conducted by retrospective cohort design in Saiful Anwar Hospital. Determination of sample amount at this study used total sampling method. Hepatic encephalopathy diagnosis was based on West Haven Criteria. Ascites was determined by physical examination and/or abdominal ultasonography. Total lymphocyte count data was taken from medical record, with complete blood count examination used XS-800i hematology analyzer machine. Data were analyzed using a logistic regression test, with p<0.05 was considered significant and Confidence Interval (CI) 95%. Seventy-eight liver cirrhosis patients were observed using a retrospective cohort method regarding the HE occurrence, and physical examination for ascites and laboratory examination were performed. The statistical analysis result of the correlation between ascites and HE is significant with an odds ratio of 5.108 and CI of 1.36-19.25. On the other hand, TLC has no significant correlation with the occurrence of HE. Based on this analysis result, it is concluded that ascites has a correlation with HE, but TLC does not. ","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80830030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.10
T. N. Kridaningsih, M. Widiyanti, S. Adiningsih, H. Hutapea, E. Fitriana, Evi Iriani Natalia
HIV-TB co-infection still becomes a health problem in Indonesia, including in Nabire district, Papua province, which has the highest number of cases. HIV and TB infections are closely related and affect the epidemiology of one another. This study aims to determine the profile description of HIV-TB co-infected patients in Nabire. This research is a descriptive study with a cross-sectional design on 90 people with HIV/AIDS selected consecutively. Data were analyzed univariately and presented in the form of a frequency distribution table. The results showed that of 55 HIV/AIDS co-infected TB patients, almost all (90.9%) were Papuan ethnic, 70.9% were female and aged 30 to 49 years (50.9%) with a mean of 31.309.36 years. The majority of HIV-TB co-infected patients were married (63.6%), holding secondary education (58.2%), working (67.3%), engaging in sexual activity after 17 years of age, only having one sexual partner, and did not use drugs or obtain blood transfusions. The clinical profile of HIV-TB patients showed that 67.3% of the patients were with baseline CD4 count ≤350 cells/mm3, 64.8% had CD4 count at the time of study >350 cells/mm3, and viral load values fewer than 5000 copies/ml (87.3%). The therapy most widely received for patients with HIV-TB coinfection was the combination of ARV 3TC+EFV+TDF (76.4%). The most common clinical symptoms of HIV/AIDS patients were weight loss (56.4%), cough (40%), recurrent oral thrush (36.4%), chickenpox (32.7%), and tuberculosis lymph nodes (18.2%).
{"title":"Profile of HIV/AIDS Patients Coinfected with Tuberculosis in Bumi Wonorejo Health Centre and Santo Rafael Clinic Nabire, Papua","authors":"T. N. Kridaningsih, M. Widiyanti, S. Adiningsih, H. Hutapea, E. Fitriana, Evi Iriani Natalia","doi":"10.21776/ub.jkb.2021.031.04.10","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.10","url":null,"abstract":"HIV-TB co-infection still becomes a health problem in Indonesia, including in Nabire district, Papua province, which has the highest number of cases. HIV and TB infections are closely related and affect the epidemiology of one another. This study aims to determine the profile description of HIV-TB co-infected patients in Nabire. This research is a descriptive study with a cross-sectional design on 90 people with HIV/AIDS selected consecutively. Data were analyzed univariately and presented in the form of a frequency distribution table. The results showed that of 55 HIV/AIDS co-infected TB patients, almost all (90.9%) were Papuan ethnic, 70.9% were female and aged 30 to 49 years (50.9%) with a mean of 31.309.36 years. The majority of HIV-TB co-infected patients were married (63.6%), holding secondary education (58.2%), working (67.3%), engaging in sexual activity after 17 years of age, only having one sexual partner, and did not use drugs or obtain blood transfusions. The clinical profile of HIV-TB patients showed that 67.3% of the patients were with baseline CD4 count ≤350 cells/mm3, 64.8% had CD4 count at the time of study >350 cells/mm3, and viral load values fewer than 5000 copies/ml (87.3%). The therapy most widely received for patients with HIV-TB coinfection was the combination of ARV 3TC+EFV+TDF (76.4%). The most common clinical symptoms of HIV/AIDS patients were weight loss (56.4%), cough (40%), recurrent oral thrush (36.4%), chickenpox (32.7%), and tuberculosis lymph nodes (18.2%).","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87247813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.1
Gery Rifano Hardanto, Selamat Budijitno, H. Hardian
Breast cancer incident continues to increase globally. The surgical management can be combined with other therapeutic modalities, including chemotherapy, radiation, and immunotherapy, such as Artemisia vulgaris (AV). This study aimed to determine the effect of AV extract on Granzyme expression and tumor mass diameter growth of C3H mice with adenocarcinoma mammae. Twenty-four female C3H mice were randomly divided into groups of K (control), P1 (AC chemotherapy), P2 (AV extract), and P3 (combination). Adenocarcinoma mammae were inoculated from donor mice. Two cycles of chemotherapy by Adriamycin 0.18 mg and Cyclophosphamide 1.8 mg were given intravenously, while Artemisia vulgaris 13 mg (0.2 ml) was given orally once per day. Granzyme expression was assessed using immunohistochemical staining, while tumor mass diameter growth was measured using tumor calipers. There was a significant negative correlation between and tumor mass diameter growth (p=0,001 and r=-0,911). Artemisia vulgaris increases the apoptotic effects of Adriamycin-Cyclophosphamide chemotherapy by increasing Granzyme expression and decreasing tumor mass diameter growth in adenocarcinoma mammae C3H mice.
{"title":"Effect of Artemisia vulgaris Extract on Granzyme Expression and Tumor Mass Diameter (Study of Adriamycin Cyclophosphamide Chemotherapy in Adenocarcinoma Mammae C3H Mice Model)","authors":"Gery Rifano Hardanto, Selamat Budijitno, H. Hardian","doi":"10.21776/ub.jkb.2021.031.04.1","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.1","url":null,"abstract":"Breast cancer incident continues to increase globally. The surgical management can be combined with other therapeutic modalities, including chemotherapy, radiation, and immunotherapy, such as Artemisia vulgaris (AV). This study aimed to determine the effect of AV extract on Granzyme expression and tumor mass diameter growth of C3H mice with adenocarcinoma mammae. Twenty-four female C3H mice were randomly divided into groups of K (control), P1 (AC chemotherapy), P2 (AV extract), and P3 (combination). Adenocarcinoma mammae were inoculated from donor mice. Two cycles of chemotherapy by Adriamycin 0.18 mg and Cyclophosphamide 1.8 mg were given intravenously, while Artemisia vulgaris 13 mg (0.2 ml) was given orally once per day. Granzyme expression was assessed using immunohistochemical staining, while tumor mass diameter growth was measured using tumor calipers. There was a significant negative correlation between and tumor mass diameter growth (p=0,001 and r=-0,911). Artemisia vulgaris increases the apoptotic effects of Adriamycin-Cyclophosphamide chemotherapy by increasing Granzyme expression and decreasing tumor mass diameter growth in adenocarcinoma mammae C3H mice.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84892323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-31DOI: 10.21776/ub.jkb.2021.031.04.4
Z. A. Prasetyo, Taufiq Nur Budaya, B. Daryanto
Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting the elderly, and Transurethral Resection of the Prostate (TURP) is a gold standard surgical procedure in BPH patients. Although the TURP rate is high, the publication of TURP profile data in Indonesia is still limited. This study aimed at determining the characteristics of BPH patients who underwent TURP at Saiful Anwar General Hospital. This study is a descriptive study by collecting data of 162 BPH patients who underwent TURP from January 2015 to August 2017. TURP is primarily performed in patients aged 61-70 years (39.5%). Recurrent urinary retention was the most common indication for the procedure (54.9%) followed by bladder stone (21%), pharmacological therapy failure (10.5%), inguinal hernia (8%), severe Lower Urinary Tract Symptoms (LUTS) (3.7%), and renal insufficiency (1.9%). As many as 58% of patients who underwent TURP had a prostate volume higher than 50 ml. Urinary retention is the most common complaint among BPH patients who underwent TURP, and recurrent urinary retention is the most common TURP indicator.
{"title":"Characteristics of Benign Prostatic Hyperplasia (BPH) Patients Undergoing Transurethral Resection of the Prostate (TURP)","authors":"Z. A. Prasetyo, Taufiq Nur Budaya, B. Daryanto","doi":"10.21776/ub.jkb.2021.031.04.4","DOIUrl":"https://doi.org/10.21776/ub.jkb.2021.031.04.4","url":null,"abstract":"Benign prostatic hyperplasia (BPH) is one of the most common diseases affecting the elderly, and Transurethral Resection of the Prostate (TURP) is a gold standard surgical procedure in BPH patients. Although the TURP rate is high, the publication of TURP profile data in Indonesia is still limited. This study aimed at determining the characteristics of BPH patients who underwent TURP at Saiful Anwar General Hospital. This study is a descriptive study by collecting data of 162 BPH patients who underwent TURP from January 2015 to August 2017. TURP is primarily performed in patients aged 61-70 years (39.5%). Recurrent urinary retention was the most common indication for the procedure (54.9%) followed by bladder stone (21%), pharmacological therapy failure (10.5%), inguinal hernia (8%), severe Lower Urinary Tract Symptoms (LUTS) (3.7%), and renal insufficiency (1.9%). As many as 58% of patients who underwent TURP had a prostate volume higher than 50 ml. Urinary retention is the most common complaint among BPH patients who underwent TURP, and recurrent urinary retention is the most common TURP indicator. ","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89633919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-27DOI: 10.21776/UB.JKB.2021.031.03.4
Wirmando Wirmando, A. Astari, Laily Yuliatun
Providing health care for criminals is very complex, stressful, and challenging for the general hospital nurses who are usually not habituated to treat them. The nurses are required to keep their caring and professional work. Providing health care for criminals puts the nurses into a risky working environment. They are susceptible to physical and psychological aggressions that can influence their practices and their applied nursing care quality. The objective of this research is to explore the general hospital nurses' experience in providing health care for the criminals. This is qualitative method research with a phenomenological approach. The data collection was done by a deep interview for 10 nurses. The applied data analysis is the Interpretative Analysis Phenomenology (IPA). The six themes found in the research are: 1) feeling discomfort in working, 2) experiencing emotional conflict, 3) working in an unsafe environment, 4) having difficulties in creating a therapeutic relationship, 5) unnatural caring emergence, and 6) not wanting the police officers to get involved in treating the patients. The security and emotional feeling factors of the nurses become the greatest challenges. They make the nurses difficult to create a therapeutic relationship and lead to unnatural caring committed by the nurses. Therefore, it is important for the nurses to internalize and reflect sincere caring as the essential principles in the nursing profession. Thus, it can reach the objectives of nursing, service equality, and patient recovery.
{"title":"The Nurses' Experience in Providing Health Care for Criminals in General Hospital","authors":"Wirmando Wirmando, A. Astari, Laily Yuliatun","doi":"10.21776/UB.JKB.2021.031.03.4","DOIUrl":"https://doi.org/10.21776/UB.JKB.2021.031.03.4","url":null,"abstract":"Providing health care for criminals is very complex, stressful, and challenging for the general hospital nurses who are usually not habituated to treat them. The nurses are required to keep their caring and professional work. Providing health care for criminals puts the nurses into a risky working environment. They are susceptible to physical and psychological aggressions that can influence their practices and their applied nursing care quality. The objective of this research is to explore the general hospital nurses' experience in providing health care for the criminals. This is qualitative method research with a phenomenological approach. The data collection was done by a deep interview for 10 nurses. The applied data analysis is the Interpretative Analysis Phenomenology (IPA). The six themes found in the research are: 1) feeling discomfort in working, 2) experiencing emotional conflict, 3) working in an unsafe environment, 4) having difficulties in creating a therapeutic relationship, 5) unnatural caring emergence, and 6) not wanting the police officers to get involved in treating the patients. The security and emotional feeling factors of the nurses become the greatest challenges. They make the nurses difficult to create a therapeutic relationship and lead to unnatural caring committed by the nurses. Therefore, it is important for the nurses to internalize and reflect sincere caring as the essential principles in the nursing profession. Thus, it can reach the objectives of nursing, service equality, and patient recovery.","PeriodicalId":17705,"journal":{"name":"Jurnal Kedokteran Brawijaya","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89326935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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