Pub Date : 2021-03-20DOI: 10.11150/kansenshogakuzasshi.95.133
Yoshinori Takahashi, R. Osawa, Masakatsu Taira, S. Ando, N. Hosokawa
{"title":"African Tick-bite Fever in a Woman who Travelled to Republic of South Africa","authors":"Yoshinori Takahashi, R. Osawa, Masakatsu Taira, S. Ando, N. Hosokawa","doi":"10.11150/kansenshogakuzasshi.95.133","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.133","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90165419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-20DOI: 10.11150/kansenshogakuzasshi.95.137
Nagisa Ujida, K. Matsubara, K. Isome, A. Iwata, Hiroshi Takegawa, Y. Sasaki, M. Ohkusu, N. Ishiwada
{"title":"Invasive Haemophilus influenzae Type f Disease Caused by a β-Lactamase-Negative Ampicillin-Resistant Strain in a 5-Year-Old Child","authors":"Nagisa Ujida, K. Matsubara, K. Isome, A. Iwata, Hiroshi Takegawa, Y. Sasaki, M. Ohkusu, N. Ishiwada","doi":"10.11150/kansenshogakuzasshi.95.137","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.137","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74724966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-20DOI: 10.11150/kansenshogakuzasshi.95.117
K. Yanagihara, N. Kaku, Hiromichi Suzuki, M. Nagao, H. Niimi, T. Matsumoto, H. Mikamo
{"title":"Results of the 1st Questionnaire Survey on the Gastrointestinal Infection","authors":"K. Yanagihara, N. Kaku, Hiromichi Suzuki, M. Nagao, H. Niimi, T. Matsumoto, H. Mikamo","doi":"10.11150/kansenshogakuzasshi.95.117","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.117","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83932958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-20DOI: 10.11150/KANSENSHOGAKUZASSHI.95.129
Naonori Maeda, N. Mori, M. Shinjoh, O. Komiyama
{"title":"Perinatal-neonatal Management of an Infant Born to a Mother with COVID-19 Infection： Prevention of the Mother-to-child Transmission and Nosocomial Infection","authors":"Naonori Maeda, N. Mori, M. Shinjoh, O. Komiyama","doi":"10.11150/KANSENSHOGAKUZASSHI.95.129","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.95.129","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76420109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.11150/KANSENSHOGAKUZASSHI.95.32
M. Ujiie, Y. Kato, J. Kuroki, Toshikazu Terashima, Toshiyuki Ito, Tomohiro Asaoka, M. Shirano, Y. Kakinoki
The novel coronavirus disease 2019 (COVID-19) was first reported to the World Health Organization by the WHO country office in China in December 2019 and has since become a worldwide pandemic In Japan, COVID-19 is a designated infectious disease under the Infectious Disease Control Act, meaning that hospitalization or isolation measures are required for infected persons It has been noted that in some cases, patients show positive PCR test results even after discharge from the hospital upon meeting the discharge criteria for COVID-19 However, so far, there is a lack of substantial evidence on the pathogenesis of re-infection or relapse in patients with COVID-19 We report 4 cases of COVID-19 who showed repeat-positive PCR test results for SARS-COV-2 after discharge from the hospital, and assessed their infectivity using clinical information collected via a public epidemiological survey All 4 cases showed a repeat-positive PCR test results within 40 days of the initial onset of symptoms All the PCR test results showed high Ct values of 33 or higher in the repeat-positive test In addition, neutralizing antibodies were detected in all cases within 3 days from the date of the repeat-positive test Furthermore, an epidemiological survey was conducted in 18 persons who were in close contact with the 4 cases, and 11 of them tested negative by the PCR test, and no case of secondary infection was found Based on these findings, the risk of secondary infection from the 4 cases was considered as low No specimens collected at the time of the first infection or virus culture test results were available for further evaluation Issues remain to be resolved in respect of the systems needed for cooperation with healthcare providers and the laboratory testing required for the evaluation of re-infection In order to further elucidate the pathogenesis of COVID-19, and to provide appropriate medical care, it is essential to evaluate the infectivity of patients with a repeat-positive PCR test and to accumulate further knowledge about the disease
{"title":"A Review of Four Cases of COVID-19 with a Repeat-positive PCR Test for SARS-CoV-2 after Hospital Discharge","authors":"M. Ujiie, Y. Kato, J. Kuroki, Toshikazu Terashima, Toshiyuki Ito, Tomohiro Asaoka, M. Shirano, Y. Kakinoki","doi":"10.11150/KANSENSHOGAKUZASSHI.95.32","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.95.32","url":null,"abstract":"The novel coronavirus disease 2019 (COVID-19) was first reported to the World Health Organization by the WHO country office in China in December 2019 and has since become a worldwide pandemic In Japan, COVID-19 is a designated infectious disease under the Infectious Disease Control Act, meaning that hospitalization or isolation measures are required for infected persons It has been noted that in some cases, patients show positive PCR test results even after discharge from the hospital upon meeting the discharge criteria for COVID-19 However, so far, there is a lack of substantial evidence on the pathogenesis of re-infection or relapse in patients with COVID-19 We report 4 cases of COVID-19 who showed repeat-positive PCR test results for SARS-COV-2 after discharge from the hospital, and assessed their infectivity using clinical information collected via a public epidemiological survey All 4 cases showed a repeat-positive PCR test results within 40 days of the initial onset of symptoms All the PCR test results showed high Ct values of 33 or higher in the repeat-positive test In addition, neutralizing antibodies were detected in all cases within 3 days from the date of the repeat-positive test Furthermore, an epidemiological survey was conducted in 18 persons who were in close contact with the 4 cases, and 11 of them tested negative by the PCR test, and no case of secondary infection was found Based on these findings, the risk of secondary infection from the 4 cases was considered as low No specimens collected at the time of the first infection or virus culture test results were available for further evaluation Issues remain to be resolved in respect of the systems needed for cooperation with healthcare providers and the laboratory testing required for the evaluation of re-infection In order to further elucidate the pathogenesis of COVID-19, and to provide appropriate medical care, it is essential to evaluate the infectivity of patients with a repeat-positive PCR test and to accumulate further knowledge about the disease","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85889992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.11150/kansenshogakuzasshi.95.1
T. Takazono, T. Miyazaki, Yuki Yoshida, S. Kojima, N. Hosogaya, H. Mukae
Background ： Elderly subjects aged 75 or over with influenza are considered at high risk of developing severe influenza and influenza-related complications. Therefore, early therapeutic intervention with anti-influenza medications is more important in elderly patients. randomized of global phase III study in patients at high risk of influenza-related complications (CAPSTONE-2, N=2,184) analyzed in a subgroup of patients 75 years of or older (N=156). The primary endpoint the to improvement of (TTIIS). The clinical secondary endpoints the resolution of and the virological secondary endpoints included the change in infectious virus titer. In addition, adverse events were also assessed as the safety endpoint. compared to the placebo or oseltamivir group. In regard to adverse events, no clear differences were observed among three groups. Conclusions ： Baloxavir was superior to placebo in alleviating the symptoms of influenza in patients aged 75 or older. The results suggest a larger treatment benefit of baloxavir as compared to that of oseltamivir, based on the greater degree of reduction in the influenza virus titers.
{"title":"Efficacy and Safety of Baloxavir Marboxil in Influenza Patients aged 75 or Over： A Sub-Group Analysis of CAPSTONE-2 Study","authors":"T. Takazono, T. Miyazaki, Yuki Yoshida, S. Kojima, N. Hosogaya, H. Mukae","doi":"10.11150/kansenshogakuzasshi.95.1","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.1","url":null,"abstract":"Background ： Elderly subjects aged 75 or over with influenza are considered at high risk of developing severe influenza and influenza-related complications. Therefore, early therapeutic intervention with anti-influenza medications is more important in elderly patients. randomized of global phase III study in patients at high risk of influenza-related complications (CAPSTONE-2, N=2,184) analyzed in a subgroup of patients 75 years of or older (N=156). The primary endpoint the to improvement of (TTIIS). The clinical secondary endpoints the resolution of and the virological secondary endpoints included the change in infectious virus titer. In addition, adverse events were also assessed as the safety endpoint. compared to the placebo or oseltamivir group. In regard to adverse events, no clear differences were observed among three groups. Conclusions ： Baloxavir was superior to placebo in alleviating the symptoms of influenza in patients aged 75 or older. The results suggest a larger treatment benefit of baloxavir as compared to that of oseltamivir, based on the greater degree of reduction in the influenza virus titers.","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79627150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.11150/kansenshogakuzasshi.95.9
Yusaku Akash, Hiromichi Suzuki, Yuto Takeuch, A. Ueda, Yumi Hirose, Hironori Imai, H. Ishikawa
{"title":"Influence of Illness Duration on the Sensitivity and Specificity of Influenza Antigen Testing： A Prospective Observational Study Using Real-time PCR","authors":"Yusaku Akash, Hiromichi Suzuki, Yuto Takeuch, A. Ueda, Yumi Hirose, Hironori Imai, H. Ishikawa","doi":"10.11150/kansenshogakuzasshi.95.9","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.9","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77027233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.11150/KANSENSHOGAKUZASSHI.95.37
T. Terashima
The first wave of the coronavirus disease 2019 (COVID-19) epidemic occurred between March 2020 and May 2020 in Japan The first epidemic wave in Chiba prefecture was analyzed based on the case series reported by the official health department of Chiba prefecture The mean interval from the onset of symptoms to a definitive diagnosis by PCR was 6 9 days The number of cases of infection, onset of symptoms, and of definitive diagnosis peaked on March 31, April 2 and April 10, respectively The effective reproduction number was below 1 0 in February, 2 0 to 3 0 between March 17 and March 27, and decreased to under 1 0 again after April 2, 2020 Some patients with an infectious duration of more than 10 days showed an effective reproduction number in the 3 0 to 4 0 range at the peak of the first epidemic
{"title":"Analysis of the First Epidemic Wave of Coronavirus Disease 2019 in Chiba Prefecture","authors":"T. Terashima","doi":"10.11150/KANSENSHOGAKUZASSHI.95.37","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.95.37","url":null,"abstract":"The first wave of the coronavirus disease 2019 (COVID-19) epidemic occurred between March 2020 and May 2020 in Japan The first epidemic wave in Chiba prefecture was analyzed based on the case series reported by the official health department of Chiba prefecture The mean interval from the onset of symptoms to a definitive diagnosis by PCR was 6 9 days The number of cases of infection, onset of symptoms, and of definitive diagnosis peaked on March 31, April 2 and April 10, respectively The effective reproduction number was below 1 0 in February, 2 0 to 3 0 between March 17 and March 27, and decreased to under 1 0 again after April 2, 2020 Some patients with an infectious duration of more than 10 days showed an effective reproduction number in the 3 0 to 4 0 range at the peak of the first epidemic","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75939271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.11150/kansenshogakuzasshi.95.17
Masayuki Sasahara, A. Saito, Y. Miyasaka, T. Hayashi, Kentaro Kodama, T. Hori
{"title":"A Case of Pulmonary Nocardiosis Caused by Nocardia otitidiscaviarum in which the Causative Bacterium was Identified by MALDI-TOF MS","authors":"Masayuki Sasahara, A. Saito, Y. Miyasaka, T. Hayashi, Kentaro Kodama, T. Hori","doi":"10.11150/kansenshogakuzasshi.95.17","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.17","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90546030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.11150/KANSENSHOGAKUZASSHI.95.21
Ryuichi Sato, T. Nagasaki, Risa Kusuta, Yuma Hama, T. Ueda, Masanori Azuma, Y. Miyazaki, K. Ota, Yusuke Kusakabe, Yusei Fukushima, Y. Yasui, A. Tanaka, Y. Hasegawa
Background: Previous reports have documented ground-glass opacities (GGOs), followed by appearance of the crazy pavement pattern and consolidation as the typical findings on chest computed tomography (CT) in patients with Coronavirus Disease-2019 (COVID-19) Case: A 69-year-old man with chronic renal failure and diabetes mellitus presented with a 2-day history of fever and fatigue, without cough or sputum production Chest auscultation revealed coarse crackles at the right base Laboratory findings included a normal leukocyte count, normal serum procalcitonin level, and a slightly elevated serum C-reactive protein level Chest CT performed on day 2 after symptom onset revealed consolidation in the right lower lobe with an air bronchogram The patient was tentatively diagnosed as having bacterial pneumonia, however, antibiotic treatment with ampicillin/sulbactam yielded no improvement of the symptoms, respiratory status, or laboratory findings A repeat chest CT revealed changes in the findings of the right lower lobe from areas of focal consolidation to GGOs GGOs and areas of consolidation were also detected in the other lung lobes A polymerase chain reaction test for Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) returned a positive result Discussion: Focal areas of lung consolidation is an atypical radiological presentation of coronavirus pneumonia It is possible that the initial findings of CT represented those of bacterial pneumonia which responded to the antibiotic therapy, and that the GGOs that developed subsequently reflected new-onset SARS-CoV-2 pneumonia However, the symptom of fatigue without cough or sputum, a normal leukocyte count, and a poor response to antibiotics are not typical findings of bacterial pneumonia Our experience suggests that it is important to consider other or concomitant diseases when the initial treatment is followed by a deteriorating clinical course in patients with pneumonia Moreover, it is essential to prevent the spread of hospital-acquired infection, especially if epidemic diseases need to be included in the initial differential diagnosis
{"title":"A Case of Focal Pulmonary Consolidation with An Air Bronchogram in A Patient with Coronavirus Disease-2019","authors":"Ryuichi Sato, T. Nagasaki, Risa Kusuta, Yuma Hama, T. Ueda, Masanori Azuma, Y. Miyazaki, K. Ota, Yusuke Kusakabe, Yusei Fukushima, Y. Yasui, A. Tanaka, Y. Hasegawa","doi":"10.11150/KANSENSHOGAKUZASSHI.95.21","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.95.21","url":null,"abstract":"Background: Previous reports have documented ground-glass opacities (GGOs), followed by appearance of the crazy pavement pattern and consolidation as the typical findings on chest computed tomography (CT) in patients with Coronavirus Disease-2019 (COVID-19) Case: A 69-year-old man with chronic renal failure and diabetes mellitus presented with a 2-day history of fever and fatigue, without cough or sputum production Chest auscultation revealed coarse crackles at the right base Laboratory findings included a normal leukocyte count, normal serum procalcitonin level, and a slightly elevated serum C-reactive protein level Chest CT performed on day 2 after symptom onset revealed consolidation in the right lower lobe with an air bronchogram The patient was tentatively diagnosed as having bacterial pneumonia, however, antibiotic treatment with ampicillin/sulbactam yielded no improvement of the symptoms, respiratory status, or laboratory findings A repeat chest CT revealed changes in the findings of the right lower lobe from areas of focal consolidation to GGOs GGOs and areas of consolidation were also detected in the other lung lobes A polymerase chain reaction test for Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) returned a positive result Discussion: Focal areas of lung consolidation is an atypical radiological presentation of coronavirus pneumonia It is possible that the initial findings of CT represented those of bacterial pneumonia which responded to the antibiotic therapy, and that the GGOs that developed subsequently reflected new-onset SARS-CoV-2 pneumonia However, the symptom of fatigue without cough or sputum, a normal leukocyte count, and a poor response to antibiotics are not typical findings of bacterial pneumonia Our experience suggests that it is important to consider other or concomitant diseases when the initial treatment is followed by a deteriorating clinical course in patients with pneumonia Moreover, it is essential to prevent the spread of hospital-acquired infection, especially if epidemic diseases need to be included in the initial differential diagnosis","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89969570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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