Pub Date : 2022-03-20DOI: 10.11150/kansenshogakuzasshi.96.56
Takehito Kasamatsu, Akihiro Kajita, Kuniyori Hatakeyama, K. Uno
Objective: We investigated whether there was a difference in the antibody profile after Pfizer/BioNtech vaccination in persons who had already been infected with COVID-19 and those who had not. Method: Blood samples were obtained before, after the first dose and after the second dose of Pfizer/BioNtech vaccine inoculation in 4 subjects with a history of COVID-19 infection and 62 subjects without a history of COVID-19 infection after obtaining their informed consent. The differences in the antibody titers were examined between those with and without a prior history of COVID-19. Result: As compared with those without a prior history of COVID-19, those with a prior history of COVID-19 showed significantly higher antibody titers after the first inoculation, and the antibody titers were significantly higher than even those after the second inoculation of subjects without a prior history of COVID-19.
{"title":"Transition in the SARS-CoV2 Antibody Profile after Pfizer/BioNtech Vaccine Inoculation in Persons With and Without a History of COVID-19","authors":"Takehito Kasamatsu, Akihiro Kajita, Kuniyori Hatakeyama, K. Uno","doi":"10.11150/kansenshogakuzasshi.96.56","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.96.56","url":null,"abstract":"Objective: We investigated whether there was a difference in the antibody profile after Pfizer/BioNtech vaccination in persons who had already been infected with COVID-19 and those who had not. Method: Blood samples were obtained before, after the first dose and after the second dose of Pfizer/BioNtech vaccine inoculation in 4 subjects with a history of COVID-19 infection and 62 subjects without a history of COVID-19 infection after obtaining their informed consent. The differences in the antibody titers were examined between those with and without a prior history of COVID-19. Result: As compared with those without a prior history of COVID-19, those with a prior history of COVID-19 showed significantly higher antibody titers after the first inoculation, and the antibody titers were significantly higher than even those after the second inoculation of subjects without a prior history of COVID-19.","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75634522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-20DOI: 10.11150/kansenshogakuzasshi.96.61
H. Hagiya, K. Tokumasu, Mikako Obika, F. Otsuka
{"title":"Should Infectious Diseases Training be Mandatory in a Fellowship Program?","authors":"H. Hagiya, K. Tokumasu, Mikako Obika, F. Otsuka","doi":"10.11150/kansenshogakuzasshi.96.61","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.96.61","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74679602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.11150/kansenshogakuzasshi.96.1
Sachie Koyama, Noriyuki Watanabe, H. Karaushi, Yoshitada Taji, K. Mitsutake, Yasuhiro Ebihara
{"title":"Epidemiological Analysis of MRSA Isolated from Blood Cultures at Our Hospital","authors":"Sachie Koyama, Noriyuki Watanabe, H. Karaushi, Yoshitada Taji, K. Mitsutake, Yasuhiro Ebihara","doi":"10.11150/kansenshogakuzasshi.96.1","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.96.1","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88506072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.11150/kansenshogakuzasshi.96.25
K. Takada, S. Adachi, Takashi Otsuka, S. Tsuji, Kimihiko Yoshida, N. Tokura, Taro Nakano
{"title":"A Case of Ramsay Hunt Syndrome with Aseptic Meningitis that Developed after the Second Dose of the COVID-19 Vaccine","authors":"K. Takada, S. Adachi, Takashi Otsuka, S. Tsuji, Kimihiko Yoshida, N. Tokura, Taro Nakano","doi":"10.11150/kansenshogakuzasshi.96.25","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.96.25","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72690887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety of A Pneumococcal 13-valent Conjugate Vaccine in Elderly Japanese Patients in Daily Practice: Results of A Drug Use-Results Survey","authors":"Noriko Matsumoto, Masayuki Ohkura, Bennett Lee, Tomoyuki Hayamizu","doi":"10.11150/kansenshogakuzasshi.96.15","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.96.15","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76039609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-20DOI: 10.11150/kansenshogakuzasshi.96.29
Manri Kawakami, F. Ikeda, S. Fujioka, H. Fujita, Koji Kida, N. Ohashi
{"title":"A Case of Human Granulocytic Anaplasmosis Suspected to be Complicated by Cholangitis","authors":"Manri Kawakami, F. Ikeda, S. Fujioka, H. Fujita, Koji Kida, N. Ohashi","doi":"10.11150/kansenshogakuzasshi.96.29","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.96.29","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75455935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-20DOI: 10.11150/kansenshogakuzasshi.95.391
Kazushi Funayama
The Japanese government recommends isolation at dedicated facilities for prevention of household transmission of COVID-19, however, the relation between the time of start of isolation at facilities and the household secondary attack incidence rate is still unknown. Since COVID-19 is contagious from 2 days prior to symptom onset and the viral load is the maximal just after the onset of symptoms, we thought that household infection could have already occurred even if the patient is isolated at a facility soon after the diagnosis. Therefore, we examined the relationship between the period from 2 days before symptom onset and the start of isolation at a facility (the infection exposure period) and the household secondary attack incidence rate among 1,075 index cases in households who were under isolation at facilities. We defined transmissions in households as cases in which household secondary transmission occurred to more than one person, and the household secondary attack incidence rate as the value obtained by dividing the number of households in which secondary transmission occurred by the total number of households. Evaluation of the household secondary attack incidence rate for each infection exposure period revealed that household secondary transmission did not occur in cases with an infection exposure period of 3 days, and the household secondary incidence rate was 22.6% (95% CI, 16.9%-29.5%) for an infection exposure period of 7 days, and 45.5% (95% CI, 21.3%-72.0%) for infection exposure periods of 12 days or more (regression analysis: y=0.037x-0.047;R2=0.863;p < 0.01). These findings suggest that the household secondary attack incidence rate increased as the infection exposure period increased, and that the household secondary attack incidence rate could be reduced to half (from 45.5% for an infection exposure period of 12 days to 22.6% for a period of 7 days) if we could start isolation so as to keep the infection exposure period at 7 days or less (5 days or less after the onset).
{"title":"The Relationship Between the Time of Start of Isolation at Facilities and Prevention of Household Transmission in COVID-19 Patients","authors":"Kazushi Funayama","doi":"10.11150/kansenshogakuzasshi.95.391","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.391","url":null,"abstract":"The Japanese government recommends isolation at dedicated facilities for prevention of household transmission of COVID-19, however, the relation between the time of start of isolation at facilities and the household secondary attack incidence rate is still unknown. Since COVID-19 is contagious from 2 days prior to symptom onset and the viral load is the maximal just after the onset of symptoms, we thought that household infection could have already occurred even if the patient is isolated at a facility soon after the diagnosis. Therefore, we examined the relationship between the period from 2 days before symptom onset and the start of isolation at a facility (the infection exposure period) and the household secondary attack incidence rate among 1,075 index cases in households who were under isolation at facilities. We defined transmissions in households as cases in which household secondary transmission occurred to more than one person, and the household secondary attack incidence rate as the value obtained by dividing the number of households in which secondary transmission occurred by the total number of households. Evaluation of the household secondary attack incidence rate for each infection exposure period revealed that household secondary transmission did not occur in cases with an infection exposure period of 3 days, and the household secondary incidence rate was 22.6% (95% CI, 16.9%-29.5%) for an infection exposure period of 7 days, and 45.5% (95% CI, 21.3%-72.0%) for infection exposure periods of 12 days or more (regression analysis: y=0.037x-0.047;R2=0.863;p < 0.01). These findings suggest that the household secondary attack incidence rate increased as the infection exposure period increased, and that the household secondary attack incidence rate could be reduced to half (from 45.5% for an infection exposure period of 12 days to 22.6% for a period of 7 days) if we could start isolation so as to keep the infection exposure period at 7 days or less (5 days or less after the onset).","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75510741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-20DOI: 10.11150/kansenshogakuzasshi.95.396
Tatsuki Mura, Yoshihiro Nishita, M. Taga, Y. Iinuma
{"title":"Cases of Transmission of Human Metapneumovirus Infection Mimicking COVID-19 in Adults","authors":"Tatsuki Mura, Yoshihiro Nishita, M. Taga, Y. Iinuma","doi":"10.11150/kansenshogakuzasshi.95.396","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.95.396","url":null,"abstract":"","PeriodicalId":17713,"journal":{"name":"Kansenshogaku Zasshi","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73188574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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