R. Kasraei, F. Fadaei, F. Nejatbakhsh, M. Bozorgi, P. Mansouri, L. Shirbeigi
Background: Many patients, chiefly teenagers, seek effective treatment for acne vulgaris. Besides topical treatments, antibiotics, and anti-androgens, herbal treatments have been used against it. Objectives: This study aims to evaluate the effects of an herbal combination based on Prunus domestica L., Tamarindus indica L., Terminalia chebula L., Ziziphus jujube L., and Cassia fistula L. on acne vulgaris. Methods: This randomized, triple-blind, placebo-controlled, two-arm parallel trial was conducted in patients with mild-to-moderate acne vulgaris. Patients were randomized, 55 in each group, to receive either herbal syrup or placebo (10 cc every 8 hours) for 12 weeks and were followed for 4 weeks. The severity of acne and participants’ psychological status was assessed by acne severity index (ASI) and Cardiff acne disability index (CADI), respectively. Results: No significant changes were observed up to the sixth week of treatment in both groups (P ≥ 0.05). From 6 weeks to 12 weeks, the outcomes indicated a significant reduction in the mean number of comedones (P < 0.030), papules (P < 0.045), pustules (P < 0.026), nodules (P < 0.044), and ASI (P < 0.001) in the herbal syrup group compared to the placebo group. Nevertheless, this did not continue after 4 weeks of follow-up (16th week). Conclusions: The herbal syrup could be an alternative treatment in patients with mild to moderate acne vulgaris. Indeed, more clinical trials are needed to confirm its efficacy and safety.
{"title":"The Efficacy of a Herbal Syrup (Containing Plum, Jujube, Yellow Myrobalan, Golden Shower, Tamarind, Honey) in the Treatment of Mild to Moderate Acne Vulgaris: A Triple- Blinded Randomized Clinical Trial","authors":"R. Kasraei, F. Fadaei, F. Nejatbakhsh, M. Bozorgi, P. Mansouri, L. Shirbeigi","doi":"10.5812/jjnpp-137370","DOIUrl":"https://doi.org/10.5812/jjnpp-137370","url":null,"abstract":"Background: Many patients, chiefly teenagers, seek effective treatment for acne vulgaris. Besides topical treatments, antibiotics, and anti-androgens, herbal treatments have been used against it. Objectives: This study aims to evaluate the effects of an herbal combination based on Prunus domestica L., Tamarindus indica L., Terminalia chebula L., Ziziphus jujube L., and Cassia fistula L. on acne vulgaris. Methods: This randomized, triple-blind, placebo-controlled, two-arm parallel trial was conducted in patients with mild-to-moderate acne vulgaris. Patients were randomized, 55 in each group, to receive either herbal syrup or placebo (10 cc every 8 hours) for 12 weeks and were followed for 4 weeks. The severity of acne and participants’ psychological status was assessed by acne severity index (ASI) and Cardiff acne disability index (CADI), respectively. Results: No significant changes were observed up to the sixth week of treatment in both groups (P ≥ 0.05). From 6 weeks to 12 weeks, the outcomes indicated a significant reduction in the mean number of comedones (P < 0.030), papules (P < 0.045), pustules (P < 0.026), nodules (P < 0.044), and ASI (P < 0.001) in the herbal syrup group compared to the placebo group. Nevertheless, this did not continue after 4 weeks of follow-up (16th week). Conclusions: The herbal syrup could be an alternative treatment in patients with mild to moderate acne vulgaris. Indeed, more clinical trials are needed to confirm its efficacy and safety.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42362728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Yaghoobi, S. Ghanbari, Maryam Hataminejad, H. Azizi
Background: Surgery is the main treatment for hydatid cyst disease, during which the spillage of live protoscoleces is a major cause of hydatidosis recurrence. Scolicidal agents are used to prevent this problem. However, they may have some unpleasant side effects. Objectives: This study assessed the scolicidal effects of Alhagi maurorum hydroalcoholic extract on developing secondary cysts in BALB/c mice infected with Echinococcus granulosus parasites. Methods: BALB/c mice were inoculated intraperitoneally with viable protoscoleces. One month after the infection, the mice were randomly divided into 4 groups (7 per group). Group 1 (control group) was orally administered PBS daily. Group 2 was orally administered albendazole daily (150 mg/kg). Group 3 was orally administered Alhagi maurorum hydroalcoholic extract daily (500 mg/kg). Group 4 was orally administered Alhagi maurorum hydroalcoholic extract daily (250 mg/kg). After 6 weeks of treatment, the weight (g), size (mm), number, and fertility of hydatid cysts were measured after the euthanasia and necropsy of all mice. Results: The weight (g), size (mm), and the number of cysts was significantly lower in the groups receiving 500 mg/kg Alhagi maurorum hydroalcoholic extract, 250 mg/kg Alhagi maurorum hydroalcoholic extract, and 150 mg/kg albendazole than in the control group (P < 0.05). The fertility percentage of hydatid cysts did not show a significant difference between the four groups (P > 0.05). Moreover, there were no statistically significant differences in the parasitological parameters between the three groups: Alhagi maurorum hydroalcoholic extract 500 mg/kg, Alhagi maurorum hydroalcoholic extract 250 mg/kg, and albendazole 150 mg/kg (P > 0.05). Conclusions: The findings demonstrated the effect of Alhagi maurorum hydroalcoholic extract against protoscoleces in BALB/c mice. However, cellular and molecular research should be carried out to gain a deeper understanding of the various effects of this extract on hydatid cysts.
{"title":"Effect of Alhagi maurorum Hydroalcoholic Extract on Preventing Secondary Hydatid Cysts in BALB/c Mice","authors":"H. Yaghoobi, S. Ghanbari, Maryam Hataminejad, H. Azizi","doi":"10.5812/jjnpp-135321","DOIUrl":"https://doi.org/10.5812/jjnpp-135321","url":null,"abstract":"Background: Surgery is the main treatment for hydatid cyst disease, during which the spillage of live protoscoleces is a major cause of hydatidosis recurrence. Scolicidal agents are used to prevent this problem. However, they may have some unpleasant side effects. Objectives: This study assessed the scolicidal effects of Alhagi maurorum hydroalcoholic extract on developing secondary cysts in BALB/c mice infected with Echinococcus granulosus parasites. Methods: BALB/c mice were inoculated intraperitoneally with viable protoscoleces. One month after the infection, the mice were randomly divided into 4 groups (7 per group). Group 1 (control group) was orally administered PBS daily. Group 2 was orally administered albendazole daily (150 mg/kg). Group 3 was orally administered Alhagi maurorum hydroalcoholic extract daily (500 mg/kg). Group 4 was orally administered Alhagi maurorum hydroalcoholic extract daily (250 mg/kg). After 6 weeks of treatment, the weight (g), size (mm), number, and fertility of hydatid cysts were measured after the euthanasia and necropsy of all mice. Results: The weight (g), size (mm), and the number of cysts was significantly lower in the groups receiving 500 mg/kg Alhagi maurorum hydroalcoholic extract, 250 mg/kg Alhagi maurorum hydroalcoholic extract, and 150 mg/kg albendazole than in the control group (P < 0.05). The fertility percentage of hydatid cysts did not show a significant difference between the four groups (P > 0.05). Moreover, there were no statistically significant differences in the parasitological parameters between the three groups: Alhagi maurorum hydroalcoholic extract 500 mg/kg, Alhagi maurorum hydroalcoholic extract 250 mg/kg, and albendazole 150 mg/kg (P > 0.05). Conclusions: The findings demonstrated the effect of Alhagi maurorum hydroalcoholic extract against protoscoleces in BALB/c mice. However, cellular and molecular research should be carried out to gain a deeper understanding of the various effects of this extract on hydatid cysts.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46023052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Niroomanesh, Zeinab Shaker Ardakani, M. Shirazi, F. Haghollahi, M. Shariat, G. Amin, MirFarbod Hojati Bagheri
Background: One of the important causes of neonatal mortality and morbidity is preterm birth. There is little evidence about the role of garlic in preventing preterm labor. Objectives: This study aimed to investigate the role of garlic tablets in preventing premature birth. Methods: This is a double-blind clinical trial. Five hundred and thirty-seven singleton pregnant women in the 16th to 26th week of pregnancy with a history of threatened preterm delivery (delivery before the 37th week of pregnancy) were included in this study. The participants were randomly divided into intervention (n = 272) and control groups (n = 265). The intervention group received garlic tablets (500 mg/day) every 24 hours for 10 weeks and 250 mg intramuscular progesterone every week until 36 weeks or delivery time. The control group received placebo tablets plus 250 mg intramuscular progesterone (every week until 36 weeks). The primary outcome was the incidence of Preterm delivery (gestational age < 37 weeks). Quantitative variables were expressed as frequency and percentage and compared using the chi-square or Fisher exact test with a small sample size. Numerical data were presented as mean and standard deviation. We used the Kolmogorov-Smirnov test to determine the normality of the data distribution. After that, the relationships of continuous variables with normal distribution were investigated using the Independent T Student test, and continuous variables without normal distribution were investigated with the non-parametric Mann-Whitney test. Multivariate logistic regression analysis estimated different variables' interaction and confounding effects. Results: Four hundred and forty-five had term delivery (82.9%), and 92 (17.1%) had preterm delivery. Seventeen participants in the intervention group (6.3%) and 75 (28.3%) in the control group had preterm delivery (P < 0.001). By considering preterm labor as dependent and other independent variables, the study group (intervention or control) was the only predictor of preterm labor (OR-3.6, CI: 95%: 1.98 - 6.5, P < 0.001). Conclusions: The results showed that the combined treatment of oral garlic tablets and intramuscular progesterone significantly prolonged pregnancy or improved outcomes. Garlic tablets seem to be effective in preventing preterm birth.
{"title":"The Effect of Garlic Tablet for Preventing Preterm Labor: A Randomized Clinical Trial","authors":"S. Niroomanesh, Zeinab Shaker Ardakani, M. Shirazi, F. Haghollahi, M. Shariat, G. Amin, MirFarbod Hojati Bagheri","doi":"10.5812/jjnpp-137008","DOIUrl":"https://doi.org/10.5812/jjnpp-137008","url":null,"abstract":"Background: One of the important causes of neonatal mortality and morbidity is preterm birth. There is little evidence about the role of garlic in preventing preterm labor. Objectives: This study aimed to investigate the role of garlic tablets in preventing premature birth. Methods: This is a double-blind clinical trial. Five hundred and thirty-seven singleton pregnant women in the 16th to 26th week of pregnancy with a history of threatened preterm delivery (delivery before the 37th week of pregnancy) were included in this study. The participants were randomly divided into intervention (n = 272) and control groups (n = 265). The intervention group received garlic tablets (500 mg/day) every 24 hours for 10 weeks and 250 mg intramuscular progesterone every week until 36 weeks or delivery time. The control group received placebo tablets plus 250 mg intramuscular progesterone (every week until 36 weeks). The primary outcome was the incidence of Preterm delivery (gestational age < 37 weeks). Quantitative variables were expressed as frequency and percentage and compared using the chi-square or Fisher exact test with a small sample size. Numerical data were presented as mean and standard deviation. We used the Kolmogorov-Smirnov test to determine the normality of the data distribution. After that, the relationships of continuous variables with normal distribution were investigated using the Independent T Student test, and continuous variables without normal distribution were investigated with the non-parametric Mann-Whitney test. Multivariate logistic regression analysis estimated different variables' interaction and confounding effects. Results: Four hundred and forty-five had term delivery (82.9%), and 92 (17.1%) had preterm delivery. Seventeen participants in the intervention group (6.3%) and 75 (28.3%) in the control group had preterm delivery (P < 0.001). By considering preterm labor as dependent and other independent variables, the study group (intervention or control) was the only predictor of preterm labor (OR-3.6, CI: 95%: 1.98 - 6.5, P < 0.001). Conclusions: The results showed that the combined treatment of oral garlic tablets and intramuscular progesterone significantly prolonged pregnancy or improved outcomes. Garlic tablets seem to be effective in preventing preterm birth.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48356661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. El Bouazzi, Samira Jaouhar, F. Talbi, Zainab Toujami, Ahmed Chbihi Kaddouri, Sidi Mohamed Raoui, A. El Ouali Lalami
Background: Self-medication is a significant public health problem that negatively affects human health. Many Moroccans have turned to this practice as a form of prevention or treatment for the newly emerged coronavirus disease 2019 (COVID-19) worldwide. Objectives: This study is the first research conducted in Morocco in the context of this pandemic, aiming to explore the prevalence, sources of information, causes, and risk factors of self-medication during the pandemic period. Methods: A cross-sectional survey using a self-administered questionnaire was conducted in the city of Meknes (North Central of Morocco) from March 2022 to June 2022 to investigate the level of self-medication practices before and during the COVID-19 pandemic. Results: The survey included 400 respondents from the general population (mean age = 34.97 ± 15.8 years). The self-medication rate was obtained as 291 (72.75%). There was a statistically significant decrease in the number of respondents practicing self-medication during COVID-19 compared to the pre-pandemic period. Most medications used for self-medication to prevent or treat COVID-19 were supplements such as vitamin C (81.10%) and zinc (74.91%), followed by acetaminophen (72.51%) and herbal products (69.41%). In the bivariate logistic regression model, age, gender, education level, self-reported health, sector of activity, and medical insurance were analyzed. Multivariate analyses showed that the youngest age group (≤ 30 years) (odds ratio (OR) = 1.59; 95% confidence interval (CI): 0.96 - 2.78), university education (OR = 1.47; 95% CI: 0.87 - 2.99), and better self-reported health (OR = 2.83; 95% CI: 1.43 - 3.71) were independently associated with self-medication. Conclusions: Self-medication was a serious health concern in Morocco during the COVID-19 pandemic. This study will be of great interest to the authorities in order to develop new pandemic management strategies, particularly self-medication awareness programs.
{"title":"Self-medication During the Coronavirus Disease 2019 Pandemic in North Central of Morocco: Prevalence, Causes, and Associated Factors","authors":"O. El Bouazzi, Samira Jaouhar, F. Talbi, Zainab Toujami, Ahmed Chbihi Kaddouri, Sidi Mohamed Raoui, A. El Ouali Lalami","doi":"10.5812/jjnpp-137345","DOIUrl":"https://doi.org/10.5812/jjnpp-137345","url":null,"abstract":"Background: Self-medication is a significant public health problem that negatively affects human health. Many Moroccans have turned to this practice as a form of prevention or treatment for the newly emerged coronavirus disease 2019 (COVID-19) worldwide. Objectives: This study is the first research conducted in Morocco in the context of this pandemic, aiming to explore the prevalence, sources of information, causes, and risk factors of self-medication during the pandemic period. Methods: A cross-sectional survey using a self-administered questionnaire was conducted in the city of Meknes (North Central of Morocco) from March 2022 to June 2022 to investigate the level of self-medication practices before and during the COVID-19 pandemic. Results: The survey included 400 respondents from the general population (mean age = 34.97 ± 15.8 years). The self-medication rate was obtained as 291 (72.75%). There was a statistically significant decrease in the number of respondents practicing self-medication during COVID-19 compared to the pre-pandemic period. Most medications used for self-medication to prevent or treat COVID-19 were supplements such as vitamin C (81.10%) and zinc (74.91%), followed by acetaminophen (72.51%) and herbal products (69.41%). In the bivariate logistic regression model, age, gender, education level, self-reported health, sector of activity, and medical insurance were analyzed. Multivariate analyses showed that the youngest age group (≤ 30 years) (odds ratio (OR) = 1.59; 95% confidence interval (CI): 0.96 - 2.78), university education (OR = 1.47; 95% CI: 0.87 - 2.99), and better self-reported health (OR = 2.83; 95% CI: 1.43 - 3.71) were independently associated with self-medication. Conclusions: Self-medication was a serious health concern in Morocco during the COVID-19 pandemic. This study will be of great interest to the authorities in order to develop new pandemic management strategies, particularly self-medication awareness programs.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47227081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Sexual dysfunction is one of the most common problems of women affecting their living standards. Concerns about the side effects of chemical drugs and the tendency to use complementary medicine have led to the introduction of herbal medicines as an alternative option to improve this disorder. Objectives: This study was planned to systematically investigate the effects of herbal medicines on sexual function and sexual satisfaction of women of reproductive age. Data Sources: All related articles published in English or Persian from 2000 to February 28, 2022, were reviewed. The international databases of Google Scholar, Science Direct, PubMed, Web of Science, Scopus, and Cochrane Library, and the national SID database were searched. Then, the articles were reviewed by two independent researchers. The data were combined using meta-analysis and the random effect model. Results: The findings of 12 studies entered into the meta-analysis showed that in the group of herbal medicines, the total score of female sexual function significantly improved (0.95; %95 CI: 0.803 - 1.097) (P = 0.001). Also, the sexual satisfaction score was higher in the group of herbal medicines (0.84; %95 CI: 0.476 - 1.21), which was significant (P = 0.001). Conclusions: Herbal medicines positively affect sexual function and sexual satisfaction of women of reproductive age and can be an effective and safe treatment for female sexual dysfunction (FSD). However, more studies with larger sample sizes on women of reproductive age are needed to achieve definitive conclusions.
{"title":"The Effects of Herbal Medicines on Sexual Function and Sexual Satisfaction among Women: A Systematic Review and Meta-Analysis","authors":"Asma Zalpour, E. Zare, M. Nasiri","doi":"10.5812/jjnpp-134275","DOIUrl":"https://doi.org/10.5812/jjnpp-134275","url":null,"abstract":"Context: Sexual dysfunction is one of the most common problems of women affecting their living standards. Concerns about the side effects of chemical drugs and the tendency to use complementary medicine have led to the introduction of herbal medicines as an alternative option to improve this disorder. Objectives: This study was planned to systematically investigate the effects of herbal medicines on sexual function and sexual satisfaction of women of reproductive age. Data Sources: All related articles published in English or Persian from 2000 to February 28, 2022, were reviewed. The international databases of Google Scholar, Science Direct, PubMed, Web of Science, Scopus, and Cochrane Library, and the national SID database were searched. Then, the articles were reviewed by two independent researchers. The data were combined using meta-analysis and the random effect model. Results: The findings of 12 studies entered into the meta-analysis showed that in the group of herbal medicines, the total score of female sexual function significantly improved (0.95; %95 CI: 0.803 - 1.097) (P = 0.001). Also, the sexual satisfaction score was higher in the group of herbal medicines (0.84; %95 CI: 0.476 - 1.21), which was significant (P = 0.001). Conclusions: Herbal medicines positively affect sexual function and sexual satisfaction of women of reproductive age and can be an effective and safe treatment for female sexual dysfunction (FSD). However, more studies with larger sample sizes on women of reproductive age are needed to achieve definitive conclusions.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48182502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehrnoosh Zakerkish, A. Hemmati, Faranak Jalili Sebardan, Nader Shakiba Maram
Background: Diabetes is one of the causes of mortality worldwide. Turmeric, ginger, and black pepper have antioxidant and anti-inflammatory properties. Objectives: The present study was performed to evaluate the effect of Curcumex supplement (Turmeric herbal capsule (320 mg), ginger (150 mg), and black pepper (4 mg) on fasting blood glucose levels, HbA1c levels, insulin resistance, and serum lipid profile in type 2 diabetic patients. Methods: This study was a double-blind, randomized controlled trial conducted on 60 patients with type 2 diabetes who were randomly divided into the intervention (n=30) and placebo (n=30) groups. The intervention group received the Curcumex supplement capsule twice a day, every 12 hours for 90 days, and the placebo group received the same amount and duration of the starch capsule. At the beginning and end of the study, blood sugar indices, including fasting blood sugar levels, plasma insulin levels, HbA1C levels, HOMA-B, HOMA-IR, and lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol (Chol), triglyceride (TG), and very low-density lipoprotein (VLDL)) were assessed. Results: The mean values of age, gender, and body mass index (BMI) were not significantly different between the two groups before the study. There was a statistically significant difference and decrease between mean scores of blood sugar indices, including serum levels of HbA1C (P = 0.003), plasma insulin (P = 0.015), HOMA-IR (P = 0.001), fasting blood glucose (P = 0.06), and BMI (P = 0.016) after the intervention. After the intervention, no significant changes were not observed in other variables, such as HDL, LDL, Chol, TG, and VLDL. Conclusions: The consumption of curcumex supplement capsules in patients with type 2 diabetes reduces serum levels of HbA1C, plasma insulin, HOMA-IR, fasting blood glucose, and BMI.
{"title":"Effect of Curcumex on Serum Lipid Profile and Fasting Blood Glucose, HbA1c, and Insulin Resistance Levels in Type 2 Diabetic Patients: A Randomized, Double-Blind Clinical Trial","authors":"Mehrnoosh Zakerkish, A. Hemmati, Faranak Jalili Sebardan, Nader Shakiba Maram","doi":"10.5812/jjnpp-136383","DOIUrl":"https://doi.org/10.5812/jjnpp-136383","url":null,"abstract":"Background: Diabetes is one of the causes of mortality worldwide. Turmeric, ginger, and black pepper have antioxidant and anti-inflammatory properties. Objectives: The present study was performed to evaluate the effect of Curcumex supplement (Turmeric herbal capsule (320 mg), ginger (150 mg), and black pepper (4 mg) on fasting blood glucose levels, HbA1c levels, insulin resistance, and serum lipid profile in type 2 diabetic patients. Methods: This study was a double-blind, randomized controlled trial conducted on 60 patients with type 2 diabetes who were randomly divided into the intervention (n=30) and placebo (n=30) groups. The intervention group received the Curcumex supplement capsule twice a day, every 12 hours for 90 days, and the placebo group received the same amount and duration of the starch capsule. At the beginning and end of the study, blood sugar indices, including fasting blood sugar levels, plasma insulin levels, HbA1C levels, HOMA-B, HOMA-IR, and lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol (Chol), triglyceride (TG), and very low-density lipoprotein (VLDL)) were assessed. Results: The mean values of age, gender, and body mass index (BMI) were not significantly different between the two groups before the study. There was a statistically significant difference and decrease between mean scores of blood sugar indices, including serum levels of HbA1C (P = 0.003), plasma insulin (P = 0.015), HOMA-IR (P = 0.001), fasting blood glucose (P = 0.06), and BMI (P = 0.016) after the intervention. After the intervention, no significant changes were not observed in other variables, such as HDL, LDL, Chol, TG, and VLDL. Conclusions: The consumption of curcumex supplement capsules in patients with type 2 diabetes reduces serum levels of HbA1C, plasma insulin, HOMA-IR, fasting blood glucose, and BMI.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48173323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdolrasoul Namjou, Ebrahim Razavie, E. Heidarian, N. Yazdani, M. Rafieian-kopaei
Background: Hirudotherapy is very common in traditional Iranian medicine for treating various diseases, including hyperglycemia. However, there is no scientific research to evaluate its effect on diabetes mellitus and the possible side effects. Objectives: This study aimed to evaluate the biochemical and histopathological changes in healthy and diabetic male rats treated with leeches. Methods: This experimental study was performed on 28 male Albino Wistar rats randomly divided into control, diabetic, and two treatment groups (control and diabetic rats treated with Hirudo medicinalis). Hirudotherapy was done in 3 to 5 minutes every 5 days for 28 consecutive days. At the end of the study, blood glucose, biochemical activity of the liver, kidney, and serum lipid enzymes were evaluated by enzymatic methods. Pathological changes in liver, kidney, and pancreas tissues were studied in the experimental groups. Results: The levels of blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatinine (Cr), urea, and phosphorus significantly increased in diabetic rats treated with leeches compared to the control group (P
{"title":"Effects of Hirudotherapy in Alloxan-induced Diabetic Male Rats: Histopathological and Biochemical Changes","authors":"Abdolrasoul Namjou, Ebrahim Razavie, E. Heidarian, N. Yazdani, M. Rafieian-kopaei","doi":"10.5812/jjnpp-120208","DOIUrl":"https://doi.org/10.5812/jjnpp-120208","url":null,"abstract":"Background: Hirudotherapy is very common in traditional Iranian medicine for treating various diseases, including hyperglycemia. However, there is no scientific research to evaluate its effect on diabetes mellitus and the possible side effects. Objectives: This study aimed to evaluate the biochemical and histopathological changes in healthy and diabetic male rats treated with leeches. Methods: This experimental study was performed on 28 male Albino Wistar rats randomly divided into control, diabetic, and two treatment groups (control and diabetic rats treated with Hirudo medicinalis). Hirudotherapy was done in 3 to 5 minutes every 5 days for 28 consecutive days. At the end of the study, blood glucose, biochemical activity of the liver, kidney, and serum lipid enzymes were evaluated by enzymatic methods. Pathological changes in liver, kidney, and pancreas tissues were studied in the experimental groups. Results: The levels of blood glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatinine (Cr), urea, and phosphorus significantly increased in diabetic rats treated with leeches compared to the control group (P","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41670027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Diabetes is a chronic metabolic disease that impairs plasma lipid levels and prone a person to cardiovascular diseases. Since standard therapies in diabetes control fail in many patients, using herbal medicines in these patients has been considered. Objectives: The present study aimed to evaluate the effect of Nigella sativa (NS) seed powder on blood sugar and fat profile in type 2 diabetic patients. Methods: Eighty patients with type 2 diabetes were recruited and randomly assigned into control and experimental groups. The experimental group received a capsule containing Nigella sativa seed powder for two months, and the control group received a placebo. Blood glucose and lipid profile data were statistically analyzed at the end of two months. This study was implemented in 2019 - 2020 year, in a diabetic clinic in Khomein City. This study was conducted at a diabetic clinic in Khomein City during the 2019 - 2020 year. The groups were compared using a repeated measures analysis of variance (ANOVA) test. Results: The mean age of patients was 53.82 in the experimental group and 55.12 in the control group. In comparison between the two measurements before and after the interventions, the variables glycosylated hemoglobin (HbA1c), cholesterol (Chol), and high-density lipoprotein (HDL) showed a statistically significant difference (P = 0.0001). The interactive effect between the control and intervention groups before and after the interventions was statistically significant for the postprandial glucose (PPG) variable (P = 0.035). Conclusions: The results of our study showed that the consumption of NS seed in diabetic patients could change the fat profile and reduce hemoglobin HbA1c, which indicated that Nigella sativa seed had been effective in reducing blood sugar over time.
{"title":"The Effect of Nigella sativa Powder on Blood Sugar and Lipid Profiles in Type 2 Diabetic Patients","authors":"Javad Javaheri, M. Asgari, R. Ghafarzadegan","doi":"10.5812/jjnpp-135757","DOIUrl":"https://doi.org/10.5812/jjnpp-135757","url":null,"abstract":"Background: Diabetes is a chronic metabolic disease that impairs plasma lipid levels and prone a person to cardiovascular diseases. Since standard therapies in diabetes control fail in many patients, using herbal medicines in these patients has been considered. Objectives: The present study aimed to evaluate the effect of Nigella sativa (NS) seed powder on blood sugar and fat profile in type 2 diabetic patients. Methods: Eighty patients with type 2 diabetes were recruited and randomly assigned into control and experimental groups. The experimental group received a capsule containing Nigella sativa seed powder for two months, and the control group received a placebo. Blood glucose and lipid profile data were statistically analyzed at the end of two months. This study was implemented in 2019 - 2020 year, in a diabetic clinic in Khomein City. This study was conducted at a diabetic clinic in Khomein City during the 2019 - 2020 year. The groups were compared using a repeated measures analysis of variance (ANOVA) test. Results: The mean age of patients was 53.82 in the experimental group and 55.12 in the control group. In comparison between the two measurements before and after the interventions, the variables glycosylated hemoglobin (HbA1c), cholesterol (Chol), and high-density lipoprotein (HDL) showed a statistically significant difference (P = 0.0001). The interactive effect between the control and intervention groups before and after the interventions was statistically significant for the postprandial glucose (PPG) variable (P = 0.035). Conclusions: The results of our study showed that the consumption of NS seed in diabetic patients could change the fat profile and reduce hemoglobin HbA1c, which indicated that Nigella sativa seed had been effective in reducing blood sugar over time.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49584771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sevda Shayesteh, A. Garjani, S. Azadi, P. Asgharian
Background: Myocardial infarction (MI) is the leading cause of death among cardiovascular diseases. Reperfusion, the most harmful phase, is accompanied by inflammatory, oxidative, and apoptotic cascades in cardiomyocytes, impairing the hemodynamic and histologic status of the cardiac tissue. The Scrophularia genus is well known for the cardioprotective effects of its species, showing beneficial impacts on blood pressure and arrhythmias in previous studies. Objectives: Regarding the mechanisms involved in MI and the cardioprotective effects of the Scrophularia genus, in this study, we evaluated the cardioprotective effects of Scrophularia atropatana on MI. Methods: Isoproterenol (ISO) injections (100 mg/kg, sc, 24-hour intervals) were used to induce MI in rats. In intervention groups, two hours after the first ISO injection, 5, 10, and 20 mg/kg S. atropatana extract was administered by gavage (24-hour intervals) for three days. Cardiac hemodynamic parameters were measured by placing a catheter into the right carotid artery and the left ventricle. Total antioxidant status (TAS), malondialdehyde (MDA) and lactate levels, and histopathologic changes were evaluated. Results: Induction of MI was accompanied by declined median arterial pressure (MAP), left ventricular systolic pressure (LVSP), and total antioxidant status (TAS) levels. In contrast, the heart rate, left ventricle end-diastolic pressure (LVEDP), malondialdehyde (MDA), and lactate levels were elevated in the MI group. Scrophularia atropatana treatment increased the MAP, LVSP, and TAS levels and significantly reduced the heart rate, LVEDP, MDA, and lactate levels. Also, S. atropatana treatment prevented histopathologic changes post-MI. Conclusions: The improving effects of S. atropatana on MI injuries suggest its potential as a complementary cardioprotective medication.
{"title":"The Beneficial Effects of Scrophularia atropatana Methanolic Extract on Myocardial Infarction in Rats","authors":"Sevda Shayesteh, A. Garjani, S. Azadi, P. Asgharian","doi":"10.5812/jjnpp-134493","DOIUrl":"https://doi.org/10.5812/jjnpp-134493","url":null,"abstract":"Background: Myocardial infarction (MI) is the leading cause of death among cardiovascular diseases. Reperfusion, the most harmful phase, is accompanied by inflammatory, oxidative, and apoptotic cascades in cardiomyocytes, impairing the hemodynamic and histologic status of the cardiac tissue. The Scrophularia genus is well known for the cardioprotective effects of its species, showing beneficial impacts on blood pressure and arrhythmias in previous studies. Objectives: Regarding the mechanisms involved in MI and the cardioprotective effects of the Scrophularia genus, in this study, we evaluated the cardioprotective effects of Scrophularia atropatana on MI. Methods: Isoproterenol (ISO) injections (100 mg/kg, sc, 24-hour intervals) were used to induce MI in rats. In intervention groups, two hours after the first ISO injection, 5, 10, and 20 mg/kg S. atropatana extract was administered by gavage (24-hour intervals) for three days. Cardiac hemodynamic parameters were measured by placing a catheter into the right carotid artery and the left ventricle. Total antioxidant status (TAS), malondialdehyde (MDA) and lactate levels, and histopathologic changes were evaluated. Results: Induction of MI was accompanied by declined median arterial pressure (MAP), left ventricular systolic pressure (LVSP), and total antioxidant status (TAS) levels. In contrast, the heart rate, left ventricle end-diastolic pressure (LVEDP), malondialdehyde (MDA), and lactate levels were elevated in the MI group. Scrophularia atropatana treatment increased the MAP, LVSP, and TAS levels and significantly reduced the heart rate, LVEDP, MDA, and lactate levels. Also, S. atropatana treatment prevented histopathologic changes post-MI. Conclusions: The improving effects of S. atropatana on MI injuries suggest its potential as a complementary cardioprotective medication.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46292701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microemulsions and Natural Products","authors":"Saeed Mohammad Soleymani, A. Salimi","doi":"10.5812/jjnpp-137644","DOIUrl":"https://doi.org/10.5812/jjnpp-137644","url":null,"abstract":"<jats:p />","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49603309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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