: Medication-related Osteonecrosis of the jaw (MRONJ) is a serious but low prevalence disease in which the surgical margins of bone resection are clinically determinated by the surgeon based on subjetive parameters. Because of this, fluorescence-guided bone resection has been proposed. The objetive of this study is to describe the current knowledge of fluorescence-guided bone resection in patients with MRONJ. Scoping Review was carried out, searching the databases of PubMed, ScienceDirect and Web of Science, using the boolean operator AND and OR. Inclusion and exclusion criteria were applied. Of 66 articles, 13 were selected that met the eligibility criteriaThe technique of fluorescence with tetracyclines (FT) and autofluorescence (AF) is used, describing a success of 85 to 100 % and 77.3 to 100 % in 1 to 12.9 and 4 to 13.1 months respectively. There was 100 % Clinical-Histopathological correlation for vital and necrotic bone tissue. Fluorescence-guided bone resection is able to clinically discriminate between vital and necrotic bone tissue, allowing the delimitation of surgical margins based on objective and reproducible parameters. In addition, it allows to standardize the surgical procedure.
{"title":"Resección Ósea Guiada por Fluorescencia en Pacientes con Osteonecrosis Mandibular Asociada a Medicamentos: Scoping Review","authors":"Joaquín Roco-Bazáez, Ariel Pinto-Galleguillos, Jessika Dethlefs-Canto","doi":"10.4067/s0718-381x2022000200321","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000200321","url":null,"abstract":": Medication-related Osteonecrosis of the jaw (MRONJ) is a serious but low prevalence disease in which the surgical margins of bone resection are clinically determinated by the surgeon based on subjetive parameters. Because of this, fluorescence-guided bone resection has been proposed. The objetive of this study is to describe the current knowledge of fluorescence-guided bone resection in patients with MRONJ. Scoping Review was carried out, searching the databases of PubMed, ScienceDirect and Web of Science, using the boolean operator AND and OR. Inclusion and exclusion criteria were applied. Of 66 articles, 13 were selected that met the eligibility criteriaThe technique of fluorescence with tetracyclines (FT) and autofluorescence (AF) is used, describing a success of 85 to 100 % and 77.3 to 100 % in 1 to 12.9 and 4 to 13.1 months respectively. There was 100 % Clinical-Histopathological correlation for vital and necrotic bone tissue. Fluorescence-guided bone resection is able to clinically discriminate between vital and necrotic bone tissue, allowing the delimitation of surgical margins based on objective and reproducible parameters. In addition, it allows to standardize the surgical procedure.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"668 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120881568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.4067/s0718-381x2022000200279
Lorena Isbej, Natacha Oyarzo, M. J. Contreras, Duniel Ortuño, Marusella Lam, Patricia García
{"title":"Evaluación de la Susceptibilidad Antimicrobiana de Porphyromonas gingivalis Aisladas de Pacientes Periodontales en Población Chilena","authors":"Lorena Isbej, Natacha Oyarzo, M. J. Contreras, Duniel Ortuño, Marusella Lam, Patricia García","doi":"10.4067/s0718-381x2022000200279","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000200279","url":null,"abstract":"","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122499457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.4067/s0718-381x2022000200214
Ellen dos-Santos, Walas Cazassa Vieira, Fabiano Luiz Heggendorn
This study aims to demonstrate, through a clinical case report, the applicability of the use of microtomography (μCT) in the histopathological evaluation of a ranula lesion on the oral floor and to evaluate the use of 2 % elemental iodine solution as a contrast agent, in order to obtain a better contrast effect in a tissue sample, thus facilitating the identification of anatomical structures, the histomorphological evaluation and the potential use of μCT in the imaging diagnosis of lesions. Different parameters were evaluated for obtaining images in SkyScan 1172, in a biopsied piece, when impregnated in a 10 % formalin solution and in a 2 % elemental iodine solution, when impregnated for 24h and 48h. Contrast agent impregnation was evaluated using the Hounsfield unit. The use of μCT allowed the identification of sialoliths dispersed inside the biopsy specimen, while the impregnation with Elemental iodine 2 % for 24h resulted in a better contrast when compared to the other conditions. The use of the Hounsfield unit allowed an adequate evaluation of the contrast obtained when the different parameters of impregnation and image acquisition were applied. The comparison between the 3D images with and without a specific marker highlighted a better evidencing of the soft tissues, with an improvement in the contrast of the images, also allowing the identification of the glandular duct obstructed by the sialoliths, allowing a conclusive histopathological evaluation of the biopsied lesion.
{"title":"Pathological Evaluation by Microtomography of Ranula. Clinical Case Report","authors":"Ellen dos-Santos, Walas Cazassa Vieira, Fabiano Luiz Heggendorn","doi":"10.4067/s0718-381x2022000200214","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000200214","url":null,"abstract":"This study aims to demonstrate, through a clinical case report, the applicability of the use of microtomography (μCT) in the histopathological evaluation of a ranula lesion on the oral floor and to evaluate the use of 2 % elemental iodine solution as a contrast agent, in order to obtain a better contrast effect in a tissue sample, thus facilitating the identification of anatomical structures, the histomorphological evaluation and the potential use of μCT in the imaging diagnosis of lesions. Different parameters were evaluated for obtaining images in SkyScan 1172, in a biopsied piece, when impregnated in a 10 % formalin solution and in a 2 % elemental iodine solution, when impregnated for 24h and 48h. Contrast agent impregnation was evaluated using the Hounsfield unit. The use of μCT allowed the identification of sialoliths dispersed inside the biopsy specimen, while the impregnation with Elemental iodine 2 % for 24h resulted in a better contrast when compared to the other conditions. The use of the Hounsfield unit allowed an adequate evaluation of the contrast obtained when the different parameters of impregnation and image acquisition were applied. The comparison between the 3D images with and without a specific marker highlighted a better evidencing of the soft tissues, with an improvement in the contrast of the images, also allowing the identification of the glandular duct obstructed by the sialoliths, allowing a conclusive histopathological evaluation of the biopsied lesion.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"2022 34","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134477084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.4067/s0718-381x2022000200195
Caroline Gomes Carvalho, Bianca Rodrigues Terrabuio, Ludimila Lemes Moura, Brena Rodrigues Manzano, Guilherme Simpione, Raquel D'Aquino Garcia Caminha, P. S. da Silva Santos
˚ ABSTRACT: To report a rare case of erythema multiforme (EM) associated with methotrexate (MTX) with cutaneous and oral manifestations and to compare it to existing cases in which MTX was not used for cancer treatment. A 56-years-old female, in physical examination skin lesions and multiple oral ulcers associated with pain during manipulation were observed,˚ and underwent˚ treatment for rheumatoid arthritis with Methotrexate 2.5mg. During examination patient-reported that 15 days ago she had undergone a rheumatoid factor examination, doubling the MTX dosage (10mg / day) without doctor’s consent. The diagnostic hypothesis of EM.˚ The medical conduct consisted of the suspension of MTX and prescription of a vitamin complex with folinic acid. Local dental therapy for to control oral lesions,˚ pain control and lip hydration was performed using low-level laser therapy (Twin Laser, P: 40mW, T: 50s, DE: 50J / cm), benzydamine hydrochloride spray, purified lanolin for lip dryness, and toothpaste without sodium lauryl sulfate to prevent burning. After 12 days, there was significant remission of oral and skin signs and symptoms, which confirmed the diagnosis was EM due to MTX intoxication. Thorough clinical evaluation and anamnesis favored diagnosis and early multi-professional management provided remission of oral and skin lesions, prevented systemic complications.
摘要:报告1例罕见的甲氨蝶呤(MTX)伴发多发性红斑(EM)，伴有皮肤和口腔表现，并与现有未使用MTX治疗的病例进行比较。56岁女性，体检时发现皮肤病变，口腔溃疡多发，并伴有推拿疼痛，接受类风湿关节炎甲氨蝶呤2.5mg治疗。检查时，患者报告15天前接受类风湿因子检查，未经医生同意将甲氨蝶呤剂量加倍(10mg /天)。EM的诊断假设为:MTX悬浮液和叶酸复合维生素处方。采用低水平激光治疗(双激光，P: 40mW, T: 50s, DE: 50J / cm)，盐酸苄胺喷雾，纯化羊毛脂用于唇部干燥，不含十二烷基硫酸钠的牙膏用于预防烧灼，进行局部口腔治疗以控制口腔病变，控制疼痛和唇部水化。12天后，口腔和皮肤体征和症状明显缓解，证实诊断为MTX中毒所致的EM。全面的临床评估和记忆有助于诊断和早期多专业治疗，缓解口腔和皮肤病变，防止全身并发症。
{"title":"Oral Manifestations of Erythema Multiforme due to Methotrexate Intoxication","authors":"Caroline Gomes Carvalho, Bianca Rodrigues Terrabuio, Ludimila Lemes Moura, Brena Rodrigues Manzano, Guilherme Simpione, Raquel D'Aquino Garcia Caminha, P. S. da Silva Santos","doi":"10.4067/s0718-381x2022000200195","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000200195","url":null,"abstract":"˚ ABSTRACT: To report a rare case of erythema multiforme (EM) associated with methotrexate (MTX) with cutaneous and oral manifestations and to compare it to existing cases in which MTX was not used for cancer treatment. A 56-years-old female, in physical examination skin lesions and multiple oral ulcers associated with pain during manipulation were observed,˚ and underwent˚ treatment for rheumatoid arthritis with Methotrexate 2.5mg. During examination patient-reported that 15 days ago she had undergone a rheumatoid factor examination, doubling the MTX dosage (10mg / day) without doctor’s consent. The diagnostic hypothesis of EM.˚ The medical conduct consisted of the suspension of MTX and prescription of a vitamin complex with folinic acid. Local dental therapy for to control oral lesions,˚ pain control and lip hydration was performed using low-level laser therapy (Twin Laser, P: 40mW, T: 50s, DE: 50J / cm), benzydamine hydrochloride spray, purified lanolin for lip dryness, and toothpaste without sodium lauryl sulfate to prevent burning. After 12 days, there was significant remission of oral and skin signs and symptoms, which confirmed the diagnosis was EM due to MTX intoxication. Thorough clinical evaluation and anamnesis favored diagnosis and early multi-professional management provided remission of oral and skin lesions, prevented systemic complications.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130840756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.4067/s0718-381x2022000200227
Lorena Lírio Sossai, Guilherme da Rocha Scalzer Lopes, Lorrany Barros Del-Piero, Maria da Penha Zago-Gomes, Stephanie Rezende Alvarenga Moulin, Jefferson David Melo de Matos, Leonardo Jiro Nomura Nakano, Valdir Cabral Andrade, M. Bottino, Selva Maria Gonçalves Guerra, A. Feitosa
˚ ABSTRACT: The aim of this study was to evaluate the dental and periodontal condition of alcohol-dependents from a Brazilian Recovery Center. Sixty male individuals (30 alcoholic and 30 non-alcoholic) and aged between 32 and 72 years old were clinically evaluated. Interviews, dental and periodontal clinical examinations were obtained from all participants. The Pearson Chi-Square Test and Exact Fisher test were used to compare categorical data. The t-Student(cid:213)s test was adopted for non-categorical data. Multiple logistic regressions were used to evaluate the association of variables in the groups. The alcoholics were younger, consumed more tobacco, had lower frequency of tooth brushing and dental flossing, higher number of missing and decayed teeth, more residual root, and more teeth with presence of visible plaque index (OR = 0.5, 95 % Cl = 4.4 to 5.5), when compared to the non-alcoholics. Alcoholics at the Recovery Center performed poor oral hygiene, had higher number of sites with periodontal disease, and worse oral hygiene than non-alcoholic individuals. As regards professional follow-up, there was similarity between the groups evaluated.
{"title":"Dental and Periodontal Conditions in Alcoholics from a Brazilian Recovery Centera","authors":"Lorena Lírio Sossai, Guilherme da Rocha Scalzer Lopes, Lorrany Barros Del-Piero, Maria da Penha Zago-Gomes, Stephanie Rezende Alvarenga Moulin, Jefferson David Melo de Matos, Leonardo Jiro Nomura Nakano, Valdir Cabral Andrade, M. Bottino, Selva Maria Gonçalves Guerra, A. Feitosa","doi":"10.4067/s0718-381x2022000200227","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000200227","url":null,"abstract":"˚ ABSTRACT: The aim of this study was to evaluate the dental and periodontal condition of alcohol-dependents from a Brazilian Recovery Center. Sixty male individuals (30 alcoholic and 30 non-alcoholic) and aged between 32 and 72 years old were clinically evaluated. Interviews, dental and periodontal clinical examinations were obtained from all participants. The Pearson Chi-Square Test and Exact Fisher test were used to compare categorical data. The t-Student(cid:213)s test was adopted for non-categorical data. Multiple logistic regressions were used to evaluate the association of variables in the groups. The alcoholics were younger, consumed more tobacco, had lower frequency of tooth brushing and dental flossing, higher number of missing and decayed teeth, more residual root, and more teeth with presence of visible plaque index (OR = 0.5, 95 % Cl = 4.4 to 5.5), when compared to the non-alcoholics. Alcoholics at the Recovery Center performed poor oral hygiene, had higher number of sites with periodontal disease, and worse oral hygiene than non-alcoholic individuals. As regards professional follow-up, there was similarity between the groups evaluated.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117042199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.4067/s0718-381x2022000100013
Eduardo Quea-Cahuana, Wiliam Ramirez-Mesias, María del Carmen Manrique-Coras, Silvana Anduaga-Lescano, Rafael Morales-Vadillo, César F. Cayo-Rojas
The aim of the experimental in vitro study was to evaluate the antimicrobial efficacy of Portland cement (CP) compared with Mineral Trioxide Aggregate (MTA) against Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans) strains at 24, 48 and 72 hours after sowing. For this, the agar diffusion technique was used. The base layer was made with Müller-Hinton Agar in which 6 mm diameter holes were made in order to contain the study cements and subsequently measure the zone of microbial inhibition around the materials using a digital vernier caliper. The Student's t test was used to compare the difference between CP and MTA and the ANOVA analysis to evaluate the differences between the three study times. The results showed that both against E. faecalis and C. albicans, CP had a greater inhibition than MTA, these differences being statistically significant (p <0.05). When the three study times were compared for each cement, there were no significant differences (p> 0.05). Likewise, C. albicans presented higher inhibition values than E. faecalis in the two cements studied. It was concluded that CP had greater antimicrobial efficacy than MTA regardless of the time evaluated.
{"title":"Eficacia Antimicrobiana del Cemento Portland Comparado con el Mineral Trióxido Agregado Frente a Enterococcus faecalis y Candida albicans","authors":"Eduardo Quea-Cahuana, Wiliam Ramirez-Mesias, María del Carmen Manrique-Coras, Silvana Anduaga-Lescano, Rafael Morales-Vadillo, César F. Cayo-Rojas","doi":"10.4067/s0718-381x2022000100013","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000100013","url":null,"abstract":"The aim of the experimental in vitro study was to evaluate the antimicrobial efficacy of Portland cement (CP) compared with Mineral Trioxide Aggregate (MTA) against Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans) strains at 24, 48 and 72 hours after sowing. For this, the agar diffusion technique was used. The base layer was made with Müller-Hinton Agar in which 6 mm diameter holes were made in order to contain the study cements and subsequently measure the zone of microbial inhibition around the materials using a digital vernier caliper. The Student's t test was used to compare the difference between CP and MTA and the ANOVA analysis to evaluate the differences between the three study times. The results showed that both against E. faecalis and C. albicans, CP had a greater inhibition than MTA, these differences being statistically significant (p <0.05). When the three study times were compared for each cement, there were no significant differences (p> 0.05). Likewise, C. albicans presented higher inhibition values than E. faecalis in the two cements studied. It was concluded that CP had greater antimicrobial efficacy than MTA regardless of the time evaluated.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123891597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.4067/s0718-381x2022000100073
Rodrigo Osorio-Larraín, Francisca Morales-Lara, Jennifer Palacios-Pereira, Camila Corral-Núñez
Cerebral palsy (CP) is a neurological disorder that affects approximately 2 out of every 1,000 live births. It is described as a group of developmental disorders of movement, balance, and posture, which cause activity limitation. Some studies have suggested that CP may increase the risk of dental trauma injuries (DTI). The objective of this study was to review the available scientific evidence on the prevalence and trends of DTI in people with CP, and to compare it with the prevalence of people without it. A systematic search was carried out in Pubmed, Scielo and Lilacs. Titles and abstracts were evaluated, excluding clinical case reports, systematic reviews, duplicate articles and/ or not relevant to the topic. Articles reporting the prevalence of DTI in people with CP were included. It was extracted OSORIO-LARRAÍN, R.; MORALES-LARA, F.; PALACIOS-PEREIRA, J.; CORRAL-NÚÑEZ, C. Traumatismo dentoalveolar en personas con parálisis cerebral. Revisión sistemática y metaanálisis. Int. J. Odontostomat., 16(1):73-80, 2022.
{"title":"Traumatismo Dentoalveolar en Personas con Parálisis Cerebral. Revisión Sistemática y Metaanálisis","authors":"Rodrigo Osorio-Larraín, Francisca Morales-Lara, Jennifer Palacios-Pereira, Camila Corral-Núñez","doi":"10.4067/s0718-381x2022000100073","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000100073","url":null,"abstract":"Cerebral palsy (CP) is a neurological disorder that affects approximately 2 out of every 1,000 live births. It is described as a group of developmental disorders of movement, balance, and posture, which cause activity limitation. Some studies have suggested that CP may increase the risk of dental trauma injuries (DTI). The objective of this study was to review the available scientific evidence on the prevalence and trends of DTI in people with CP, and to compare it with the prevalence of people without it. A systematic search was carried out in Pubmed, Scielo and Lilacs. Titles and abstracts were evaluated, excluding clinical case reports, systematic reviews, duplicate articles and/ or not relevant to the topic. Articles reporting the prevalence of DTI in people with CP were included. It was extracted OSORIO-LARRAÍN, R.; MORALES-LARA, F.; PALACIOS-PEREIRA, J.; CORRAL-NÚÑEZ, C. Traumatismo dentoalveolar en personas con parálisis cerebral. Revisión sistemática y metaanálisis. Int. J. Odontostomat., 16(1):73-80, 2022.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134472304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.4067/s0718-381x2022000100023
Raquel D'Aquino Garcia Caminha, Guilherme Simpione, Vanessa Soares Soares Lara, P. S. da Silva Santos
Pazopanib, an antiangiogenic agent, has shown promising results in controlling tumor growth and metastasis in patients with renal cell carcinoma. The use of pazopanib in the management of malignancies has increased over recent years, with more patients at risk of developing medication-related osteonecrosis of the jaw (MRONJ). This paper presents the first case report of MRONJ associated with pazopanib monotherapy. A 59-year-old man was referred to the dental clinic with complaints of dysphagia and dysgeusia. The patient was prescribed pazopanib (400 mg) daily following surgical treatment and chemotherapy for metastatic renal cell carcinoma. He had undergone extraction of the maxillary left second premolar nine weeks previously. Intraoral examination revealed exposed necrotic bone, which was treated effectively with leukocyte and platelet-rich fibrin (LPRF). The patient was followed up for 150 days after dental treatment with no signs of relapse.
{"title":"Medication-Related Osteonecrosis of the Jaw Associated with Pazopanib Monotherapy","authors":"Raquel D'Aquino Garcia Caminha, Guilherme Simpione, Vanessa Soares Soares Lara, P. S. da Silva Santos","doi":"10.4067/s0718-381x2022000100023","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000100023","url":null,"abstract":"Pazopanib, an antiangiogenic agent, has shown promising results in controlling tumor growth and metastasis in patients with renal cell carcinoma. The use of pazopanib in the management of malignancies has increased over recent years, with more patients at risk of developing medication-related osteonecrosis of the jaw (MRONJ). This paper presents the first case report of MRONJ associated with pazopanib monotherapy. A 59-year-old man was referred to the dental clinic with complaints of dysphagia and dysgeusia. The patient was prescribed pazopanib (400 mg) daily following surgical treatment and chemotherapy for metastatic renal cell carcinoma. He had undergone extraction of the maxillary left second premolar nine weeks previously. Intraoral examination revealed exposed necrotic bone, which was treated effectively with leukocyte and platelet-rich fibrin (LPRF). The patient was followed up for 150 days after dental treatment with no signs of relapse.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133868243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-01DOI: 10.4067/s0718-381x2022000100109
Lucas Alves da Mota Santana, Sara Ferreira dos Santos Costa, John Nadson Andrade Pinho, Helio Igor Melo de Alburquerque, S. Martins Paiva, Wilton Mitsunari Takeshita, R. C. do Amaral, Liane Maciel de Almeida Souza
The emergence of new coronavirus variants imposed a challenge to the theory of herd immunity. The P.1 (B.1.1.28.1) and delta (B.1.617.2) lineages are more contagious and cause more severe symptoms beyond deaths. For this reason, vaccines have become the only way to control the pandemic (Lopez Bernal et al., 2021; Sabino et al., 2021). This letter discusses some points concerning the impact and benefits of the beginning of COVID-19 vaccination among oral and maxillofacial surgeons of a Public Health Center in Aracaju, Sergipe state (Northeast of Brazil). These surgeons deal every day and directly with COVID-19 patients.
新型冠状病毒变体的出现对群体免疫理论提出了挑战。P.1 (B.1.1.28.1)和delta (B.1.617.2)谱系的传染性更强，造成的症状比死亡更严重。因此，疫苗已成为控制大流行的唯一途径(Lopez Bernal et al.， 2021;Sabino et al.， 2021)。这封信讨论了在塞尔吉佩州阿拉卡朱(巴西东北部)公共卫生中心的口腔颌面外科医生中开始接种COVID-19疫苗的影响和益处。这些外科医生每天都直接与COVID-19患者打交道。
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Pub Date : 2022-03-01DOI: 10.4067/s0718-381x2022000100027
Rossana Reim Del´Gaudio Pignataro, Jefferson David Melo de-Matos, Ísis Luzcybel Ribeiro Pinto, Renata de Paulo Samico, M. Bottino, Nathália de Carvalho Ramos, Renata Marques de Melo Marinho
The most common failure in implantology are due to mechanical instability. Torque loosening or fracture of the screws are the most frequent complications. Furthermore, the fractured screw retrieval is complicated and time-consuming. So, modifications in the design of implant systems are justifiable to offer a greater degree of biomechanical stability. Thus, the present study proposes to evaluate an experimental geometry for abutment screw regarding failure probability and torque loss. Twenty implant/abutments sets (e-fix, A.S. Technology – Titanium Fix) were divided into the following groups (n=10 in each group): (1) Conventional screw (Screw neck ø 1.5 mm) and (2) Experimental screw (screw neck constricted ø 1.2 mm). The abutments were tightened with a controlled torque meter device following the manufacturer’s recommendations. Mechanical cycling was carried out with a load of 50 N.cm during 5 x 10 cycles with a frequency of 2 Hz at a temperature of 37 °C (ISO 14801). A digital torque meter was used to measure the reverse torque values of the prosthetic screw and the micro abutment screw, before and after loading. Data were statistically analyzed by One-way Anova and Tukey test (95 %). The results of the mean values of torque loss of the micro abutment screw were 58.44 % for the control group and 55.31 % for the experimental group and the mean torque loss for the prosthetic screw was 53.3 % and 61.3 % of the conventional and experimental groups, respectively. The survival probability was 100 % for both screw groups. It was concluded that experimental screw showed a similar behavior to conventional screws, showing similar reliability after fatigue life testing.
在种植术中最常见的失败是由于机械不稳定。扭矩松动或螺钉断裂是最常见的并发症。此外，螺钉复位复杂且费时。因此，修改植入系统的设计是合理的，以提供更大程度的生物力学稳定性。因此，本研究提出了一种关于失效概率和扭矩损失的基台螺钉的实验几何形状。20组种植体/基台(e-fix, A.S. Technology - Titanium Fix)分为以下组(每组n=10):(1)常规螺钉(螺钉颈ø 1.5 mm)和(2)实验螺钉(螺钉颈缩窄ø 1.2 mm)。根据制造商的建议，用控制扭矩计装置拧紧基台。在温度为37°C (ISO 14801)的条件下，以50n .cm的载荷在5 x 10次循环中以2 Hz的频率进行机械循环。采用数字扭矩计测量假体螺钉和微基台螺钉在加载前后的反向扭矩值。资料采用单因素方差分析和Tukey检验(95%)进行统计学分析。结果:对照组微基牙螺钉的扭矩损失平均值为58.44%，试验组为55.31%，常规组和试验组的假体螺钉的扭矩损失平均值分别为53.3%和61.3%。两组患者的生存率均为100%。试验结果表明，试验螺杆与常规螺杆具有相似的性能，在疲劳寿命试验中表现出相似的可靠性。
{"title":"Survival Analysis and Torque Loosening of Experimental Screw After Mechanical Performance for Micro Conical Abutment","authors":"Rossana Reim Del´Gaudio Pignataro, Jefferson David Melo de-Matos, Ísis Luzcybel Ribeiro Pinto, Renata de Paulo Samico, M. Bottino, Nathália de Carvalho Ramos, Renata Marques de Melo Marinho","doi":"10.4067/s0718-381x2022000100027","DOIUrl":"https://doi.org/10.4067/s0718-381x2022000100027","url":null,"abstract":"The most common failure in implantology are due to mechanical instability. Torque loosening or fracture of the screws are the most frequent complications. Furthermore, the fractured screw retrieval is complicated and time-consuming. So, modifications in the design of implant systems are justifiable to offer a greater degree of biomechanical stability. Thus, the present study proposes to evaluate an experimental geometry for abutment screw regarding failure probability and torque loss. Twenty implant/abutments sets (e-fix, A.S. Technology – Titanium Fix) were divided into the following groups (n=10 in each group): (1) Conventional screw (Screw neck ø 1.5 mm) and (2) Experimental screw (screw neck constricted ø 1.2 mm). The abutments were tightened with a controlled torque meter device following the manufacturer’s recommendations. Mechanical cycling was carried out with a load of 50 N.cm during 5 x 10 cycles with a frequency of 2 Hz at a temperature of 37 °C (ISO 14801). A digital torque meter was used to measure the reverse torque values of the prosthetic screw and the micro abutment screw, before and after loading. Data were statistically analyzed by One-way Anova and Tukey test (95 %). The results of the mean values of torque loss of the micro abutment screw were 58.44 % for the control group and 55.31 % for the experimental group and the mean torque loss for the prosthetic screw was 53.3 % and 61.3 % of the conventional and experimental groups, respectively. The survival probability was 100 % for both screw groups. It was concluded that experimental screw showed a similar behavior to conventional screws, showing similar reliability after fatigue life testing.","PeriodicalId":177464,"journal":{"name":"International journal of odontostomatology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129284832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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