ABSTRACT Presently the community tends to avoid the use of modern medicine and turn to nature (back to nuture) with traditional medicine using medicinal plants. The exploration of medicinal plant used in traditional medicine in Pidie District aims to explore the potential of plant species used, record the plant parts used, how to process and to use the plants and how to obtain them from the nature habitat. The method used for data collection is exploratory surveys and Participatory Rural Appraisal (PRA) methods. The data obtained were analyzed descriptively and showed in the form of tables and images. The results of the study found 106 types of plants used in traditional medicine that were spread into 67 plant families. The most widely used of medicinal plant species were from the Zingiberaceae family. The most widely used plant part is the leaf part. The method of medicinal processing is done by boiling (decoction), the results of the ingredients are used as oral administration by drinks. Generally, the plants used for medicine by the people of Pidie Distric are wild plants, and 68% of which grow from home gardens and fields. ABSTRAK Kecenderungan masyarakat saat ini mulai menolak penggunaan obat moderen dan beralih ke alam (back to nuture) dengan pengobatan tradisional menggunakan tumbuhan obat. Ekspolarsi jenis tumbuhan obat yang digunakan dalam pengobatan tradisonal di Kabupaten Pidie bertujuan untuk menggali potensi jenis tumbuhan yang digunakan, mendata bagian yang digunakan, cara pengolahan dan penggunaan tumbuhan serta cara mendapatkannya dari alam. Metode yang dilakukan dalam pengumpulan data adalah survey eksploratif dan Participatory Rural Appraisal (PRA). Data yang diperoleh dianalisa secara deskriptif dan ditampilkan dalam bentuk tabel dan gambar. Hasil penelitian didapatkan 106 spesies tumbuhan obat yang digunakan dalam pengobatan tradisional yang berasal dari 67 famili. Spesies tumbuhan obat yang paling banyak digunakan di wilayah Pidie berasal dari famili Zingiberaceae. Bagian tumbuhan obat yang paling banyak digunakan adalah bagian daun. Cara pengolahan tumbuhan obat secara umum dilakukan dengan perebusan, hasil ramuan digunakan dalam bentuk minuman. Secara umum tumbuhan yang digunakan untuk obat oleh masyarakat Kabupaten Pidie adalah jenis tumbuhan liar, dan sebanyak 68% tumbuh dari pekarangan rumah maupun kebun atau ladang.
摘要:目前，社会倾向于避免使用现代医学而转向自然(回归自然)，使用药用植物的传统医学。Pidie地区传统医学药用植物开发旨在发掘植物品种的利用潜力，记录植物的使用部位，如何加工和利用植物，以及如何从自然栖息地获取植物。数据收集方法采用探索性调查和参与式农村评估(PRA)方法。对所得数据进行描述性分析，并以表格和图像的形式显示。研究结果发现，106种用于传统医学的植物分布在67个植物科中。应用最广泛的药用植物是姜科植物。最广泛使用的植物部分是叶子部分。药物加工的方法是通过煮沸(煎煮)，其成分的结果被用作饮料的口服给药。一般来说，皮迪区人民用于医药的植物是野生植物，其中68%生长在家庭花园和田地里。【摘要】蒙古古纳罕土豆泥是一种传统的土豆泥，传统的土豆泥是一种现代土豆泥。Ekspolarsi jenis tumunakan obat yang digunakan dalam pengobatan传统di Kabupaten Pidie bertujuan untuk menggali潜能jenis tumbuhan yang digunakan, mendata bagian yang digunakan, cara pengolahan dan penggunaan tumbuhan serta cara mendapatkanya dari alam。研究了参与式农村评价(PRA)在农村发展中的应用。数据yang diperoleh dianalisa secara deskriptif dan ditampilkan dalam bentuk tabel dan gambar。Hasil penelitian didapatkan 106种tumbuhan obat yang digunakan dalam pengobatan传统yang berasal dari 67科。姜科植物:姜科植物。Bagian tumbuhan obat yang paling banyak digunakan adalah Bagian daun。卡拉蓬戈拉罕tumbuhan obat secara umumumdilakukan dengan perbusan, hasil ramuan digunakan dalam bentuk minuman。Secara umum tumbuhan yang digunakan untuk obat oleh masyarakat Kabupaten Pidie adalah jenis tumbuhan liar, dan sebanyak 68% tumbuh dari pekarangan rumah maupun kebun atau ladang。
{"title":"EKSPLORASI SPESIES TUMBUHAN BERKHASIAT OBAT BERBASIS PENGETAHUAN LOKAL DI KABUPATEN PIDIE","authors":"Saudah Saudah, Vera Viena, Ernilasari Ernilasari","doi":"10.22435/jtoi.v12i2.952","DOIUrl":"https://doi.org/10.22435/jtoi.v12i2.952","url":null,"abstract":"ABSTRACT \u0000Presently the community tends to avoid the use of modern medicine and turn to nature (back to nuture) with traditional medicine using medicinal plants. The exploration of medicinal plant used in traditional medicine in Pidie District aims to explore the potential of plant species used, record the plant parts used, how to process and to use the plants and how to obtain them from the nature habitat. The method used for data collection is exploratory surveys and Participatory Rural Appraisal (PRA) methods. The data obtained were analyzed descriptively and showed in the form of tables and images. The results of the study found 106 types of plants used in traditional medicine that were spread into 67 plant families. The most widely used of medicinal plant species were from the Zingiberaceae family. The most widely used plant part is the leaf part. The method of medicinal processing is done by boiling (decoction), the results of the ingredients are used as oral administration by drinks. Generally, the plants used for medicine by the people of Pidie Distric are wild plants, and 68% of which grow from home gardens and fields. \u0000ABSTRAK \u0000Kecenderungan masyarakat saat ini mulai menolak penggunaan obat moderen dan beralih ke alam (back to nuture) dengan pengobatan tradisional menggunakan tumbuhan obat. Ekspolarsi jenis tumbuhan obat yang digunakan dalam pengobatan tradisonal di Kabupaten Pidie bertujuan untuk menggali potensi jenis tumbuhan yang digunakan, mendata bagian yang digunakan, cara pengolahan dan penggunaan tumbuhan serta cara mendapatkannya dari alam. Metode yang dilakukan dalam pengumpulan data adalah survey eksploratif dan Participatory Rural Appraisal (PRA). Data yang diperoleh dianalisa secara deskriptif dan ditampilkan dalam bentuk tabel dan gambar. Hasil penelitian didapatkan 106 spesies tumbuhan obat yang digunakan dalam pengobatan tradisional yang berasal dari 67 famili. Spesies tumbuhan obat yang paling banyak digunakan di wilayah Pidie berasal dari famili Zingiberaceae. Bagian tumbuhan obat yang paling banyak digunakan adalah bagian daun. Cara pengolahan tumbuhan obat secara umum dilakukan dengan perebusan, hasil ramuan digunakan dalam bentuk minuman. Secara umum tumbuhan yang digunakan untuk obat oleh masyarakat Kabupaten Pidie adalah jenis tumbuhan liar, dan sebanyak 68% tumbuh dari pekarangan rumah maupun kebun atau ladang. \u0000 ","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74052243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT The process of excessive free radicals in our body plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. The recently study reported that free radical and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Therefore, natural antioxidants can be explored to prevent degenerative diseases and in the present paper we have investigated antioxidant activity of extracts from Nicolaia speciose (Bl.) Horan flower and Muntingia calabura L. fruit for its free radical scavenging activity using 2,2-diphenyl, 1-picryl hydrazil (DPPH) radical scavenging activity. The results revealed that both ethyl acetate fractions of N. speciaose and M. calabura have the highest antioxidant activitiy with IC50 29.81 and 14.48 µg/ml respectively. The antioxidant activity of both ethanolic extracts were more potent than hexan and water fractions with IC50 39.27 and 137.20 µg/ml respectively. The investigation of IC50 values indicated that the antioxidant activity show moderate to very active. Active compounds were identified using thin layer chromatography with FeCl3, AlCl3, 2,4-DNPH and anisaldehide-H2SO4 spray reagents. Chromatogram of ethylacetate fraction showed that spots on the hRf 12 and 56 were thought to contain phenolic compounds with a carbonyl group, while the hRf 37 was suspected flavone compounds with 3-OH group and the hRf 50 was alleged the ortho-dihydroxy flavone or ortho hydroxy and free carbonyl. Chromatogram of ethyl acetate of talok fruits fraction showed that spots on the hRf 19.31 and 44 were suspected flavone compounds with ortho-hydroxy-carbonyl group and or ortho-hydroxy. ABSTRAK Radikal bebas berlebih dalam tubuh dapat memicu tumbuhnya sel kanker, penyumbatan pembuluh jantung, kerusakan oksidatif otak dan penuaan dini. Hal ini menyebabkan penelitian tentang potensi antioksidan terus mengalami peningkatan, terutama antioksidan alami dari tanaman. Bunga kecombrang (Nicolaia speciosa (BI.) Horan) dan buah talok (Muntingia Calabura L.) dilaporkan aktif sebagai antioksidan dan mengandung senyawa aktif dengan tingkat kepolaran yang berbeda. Oleh karena itu, penelitian ini bertujuan untuk menguji aktivitas dengan penangkapan radikal bebas fraksi-fraksi ekstrak bunga kecombrang dan buah talok serta karakterisasi golongan senyawa aktifnya. Hasil fraksinasi ekstrak diuji dengan larutan DPPH 0,4 mM dan diukur dengan spektrofotometer UV-Vis pada panjang gelombang 517 nm. Hasil absorbansi sampel dan kontrol diolah untuk mendapatkan persen penangkapan radikal DPPH dan aktivitas antioksidan dievaluasi melalui nilai IC50. Senyawa aktif diidentifikasi menggunakan kromatografi lapis tipis dengan penampak bercak FeCl3, AlCl3, 2,4-DNPH dan anisaldehid-H2SO4. Fraksi-fraksi ekstrak bunga kecombrang dan buah talok menunjukkan tingkat kekuatan
我们体内自由基过多的过程在慢性和退行性疾病如癌症、自身免疫性疾病、衰老、白内障、类风湿关节炎、心血管和神经退行性疾病的发展中起着重要作用。最近的研究报告说，自由基和氧化剂扮演着双重角色，既是有毒的，也是有益的化合物，因为它们对身体可能有害，也可能有益。因此，天然抗氧化剂可用于预防退行性疾病，本研究对Nicolaia speciose (Bl.) Horan花和Muntingia calabura L.果实提取物的抗氧化活性进行了研究，利用2,2-二苯基，1-苦胆酰肼(DPPH)自由基清除活性进行了研究。结果表明，两种部位的抗氧化活性最高，IC50分别为29.81和14.48µg/ml。乙醇提取物的抗氧化活性均高于正己烷和水提取物，IC50分别为39.27和137.20µg/ml。IC50值的测定表明，其抗氧化活性为中~极活性。用FeCl3, AlCl3, 2,4- dnph和茴香醛- h2so4喷雾试剂进行薄层色谱鉴定。乙酸乙酯组分的色谱分析表明，hrf12和hrf56上的斑点可能含有含有羰基的酚类化合物，hrf37上的斑点可能含有含有3-OH基团的黄酮化合物，hrf50上的斑点可能含有邻二羟基黄酮或邻羟基游离羰基。桃果提取物的乙酸乙酯层析表明，hrf19.31和hrf44上的斑点为邻羟基羰基和邻羟基疑似黄酮类化合物。【摘要】根茎性bebeas berlebih dalam tubuh dapat memicu tumbuhnya sel kanker, penyumbatan penbuluh jantung, kerusakan okatiff, takak和penuuah dini。Hal ini menyebabkan penelitian tentang potentii antioksidan terus mengalami peningkatan, terutama antioksidan alami dari tanaman。邦加·科姆布兰(Nicolaia speciosa) (BI.)【翻译】【译文】【译文】破旧的，破旧的】【译文】【译文】【译文】我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是，我想说的是。Hasil fraksinasi ekstrak diukur dengan larutan DPPH 0,4 mM丹diukur dengan光谱英尺紫外-可见帕达panjang gelombang 517 nm。采用吸光度法和对照法，研究了三聚氰胺的抗氧化活性、抗氧化活性和抗氧化活性。Senyawa aktif diidentitikasi menggunakan kema . dengan penampak bercak FeCl3, alcl3,2,4 - dnph和茴香醛- h2so4。我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说，我是说。Fraksi的用法和样例:Fraksi的用法和样例:Fraksi的用法和样例:Fraksi的用法和样例:帕特拉克是一名印度裔美国人，但他说，这是一项潜在的反俄活动，是一项反俄活动，是一项反俄活动。Fraksi air, ekstrak乙醇serta, Fraksi heksan bunga kecombrang memiliki IC50 sebesar 39,27µg/ml, 44,08µg/ml, dan 135,36µg/ml。Sedangkan ekstrak乙醇，fraksi air, fraksi heksan buah talok memiliki IC50 sebesar 137,20µg/ml, 282,47µg/ml, dan 2611,70µg/ml。Hasil KLT fraksi - asetat buah komkombrang menunjukkan bahwa berkkpa hRf 12 dan 56 mengandung senyawa fenolik dengan gugus karbonil, sedangkan hRf 37 diduga senyawa flavon dengan gugus 3-OH danpada hRf 50 merupakan flavon dengan -dihidroksi dan atau -hidroksi karbonil bebas。Kemudian hasil KLT fraksi etil asetat buah talok menunjukkan bahwa bercak dengan汝hRf 19日31日丹44 merupakan flavon dengan gugu o-hidroksi karbonil丹atau gugu o-dihidroksi。Bercak pada hrf31 juga menginkasikan adanya senyawa萜类化合物。
{"title":"UJI PENANGKAPAN RADIKAL 2,2-difenil-1-pikrilhidrazil (DPPH) OLEH EKSTRAK ETANOL BUNGA KECOMBRANG (Nicolaia speciosa (Bl.) Horan) DAN BUAH TALOK (M. calabura L. )","authors":"Tatang Irianti, Hari Purnomo, Kuswandi Kuswandi, Sindu Nuranto, Damiana Nitya Kanistri, Yosi Bayu Murti, Sofa Farida","doi":"10.22435/jtoi.v12i1.1582","DOIUrl":"https://doi.org/10.22435/jtoi.v12i1.1582","url":null,"abstract":"ABSTRACT \u0000The process of excessive free radicals in our body plays a major part in the development of chronic and degenerative illness such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, cardiovascular and neurodegenerative diseases. The recently study reported that free radical and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. Therefore, natural antioxidants can be explored to prevent degenerative diseases and in the present paper we have investigated antioxidant activity of extracts from Nicolaia speciose (Bl.) Horan flower and Muntingia calabura L. fruit for its free radical scavenging activity using 2,2-diphenyl, 1-picryl hydrazil (DPPH) radical scavenging activity. The results revealed that both ethyl acetate fractions of N. speciaose and M. calabura have the highest antioxidant activitiy with IC50 29.81 and 14.48 µg/ml respectively. The antioxidant activity of both ethanolic extracts were more potent than hexan and water fractions with IC50 39.27 and 137.20 µg/ml respectively. The investigation of IC50 values indicated that the antioxidant activity show moderate to very active. Active compounds were identified using thin layer chromatography with FeCl3, AlCl3, 2,4-DNPH and anisaldehide-H2SO4 spray reagents. Chromatogram of ethylacetate fraction showed that spots on the hRf 12 and 56 were thought to contain phenolic compounds with a carbonyl group, while the hRf 37 was suspected flavone compounds with 3-OH group and the hRf 50 was alleged the ortho-dihydroxy flavone or ortho hydroxy and free carbonyl. Chromatogram of ethyl acetate of talok fruits fraction showed that spots on the hRf 19.31 and 44 were suspected flavone compounds with ortho-hydroxy-carbonyl group and or ortho-hydroxy. \u0000ABSTRAK \u0000Radikal bebas berlebih dalam tubuh dapat memicu tumbuhnya sel kanker, penyumbatan pembuluh jantung, kerusakan oksidatif otak dan penuaan dini. Hal ini menyebabkan penelitian tentang potensi antioksidan terus mengalami peningkatan, terutama antioksidan alami dari tanaman. Bunga kecombrang (Nicolaia speciosa (BI.) Horan) dan buah talok (Muntingia Calabura L.) dilaporkan aktif sebagai antioksidan dan mengandung senyawa aktif dengan tingkat kepolaran yang berbeda. Oleh karena itu, penelitian ini bertujuan untuk menguji aktivitas dengan penangkapan radikal bebas fraksi-fraksi ekstrak bunga kecombrang dan buah talok serta karakterisasi golongan senyawa aktifnya. Hasil fraksinasi ekstrak diuji dengan larutan DPPH 0,4 mM dan diukur dengan spektrofotometer UV-Vis pada panjang gelombang 517 nm. Hasil absorbansi sampel dan kontrol diolah untuk mendapatkan persen penangkapan radikal DPPH dan aktivitas antioksidan dievaluasi melalui nilai IC50. Senyawa aktif diidentifikasi menggunakan kromatografi lapis tipis dengan penampak bercak FeCl3, AlCl3, 2,4-DNPH dan anisaldehid-H2SO4. Fraksi-fraksi ekstrak bunga kecombrang dan buah talok menunjukkan tingkat kekuatan ","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74810305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.22435/jtoi.v12i1.1807
N. Rahmawati, I. Sholikhah
ABSTRACT Talinum paniculatum (som Java) reported to have many pharmacological activities such as increasing spermatozoa quality, cell regenerations, fertility, and antibacterial effect both empirically and scientifically. This study aimed to prove the combination infusion effects of som Java, gotu kola, and temulawak on introduction, climbing, and coitus levels as well as testosterone levels in male Sprague Dawley (SD) rats. SD rats were divided into 2 groups, control group received aquadest, treatment group received formula a mixture of som java Talinum paniculatum) root, gotu kola (Centella asiatica) herb, and Javanese turmeric (Curcuma xanthorrhiza) rhizome with the dose of 491,2 mg/200 g BW for 7 consecutive days. Artificial estrus of female SD rats were induced by administering estradiol valerat 2 mg/200 g BW 48 hours before observation. The determined parameters were levels of testosterone as well as introduction, climbing and coitus frequencies. Administration of estradiol valerat led to artificial estrus induction of female SD rats. The administration of the combination infusion dose 491.2 mg/200 g BW significantly increased testosterone level as well as introduction and climbing frequencies of male SD rats as of 27.77%; 86.39% and 69.17% respectively. ABSTRAK Som jawa (Talinum paniculatum) secara empiris dan ilmiah terbukti telah banyak dimanfaatkan oleh masyarakat untuk mengatasi berbagai masalah kesehatan diantaranya untuk meningkatkan kualitas dan kuantitas spermatozoa, regenerasi sel, fertilitas, dan sebagai antibakteri. Penelitian ini dilakukan untuk membuktikan efek peningkatan kadar hormon testosteron serta frekuensi introduction, climbing, dan coitus tikus jantan SD dari pengaruh infusa kombinasi som jawa, pegagan, dan temulawak. Hewan uji tikus galur SD dibagi menjadi 2 kelompok, yaitu kelompok kontrol diberikan akuades, sedangkan kelompok perlakuan diberikan infusa ramuan akar som jawa, herba pegagan, dan rimpang temulawak dosis 491,2 mg/200 g bb selama 7 hari berturut-turut. Induksi estrus artifisial tikus betina dengan pemberian estradiol valerat 2 mg/200 g bb dilakukan 48 jam sebelum pengamatan. Parameter yang diukur meliputi kadar testosterone, frekuensi introduction, climbing, dan coitus. Dibandingkan dengan kelompok kontrol, pemberian infusa ramuan tidak berefek pada frekunsi coitus, namun mampu meningkatkan kadar testosteron serta frekuensi introduction dan climbing tikus jantan sebesar 27,77; 86,39 dan 69,17%.
摘要经实证和科学报道，爪哇Talinum paniculatum (som Java)具有提高精子质量、细胞再生、生育能力和抗菌作用等药理活性。本研究旨在证明苏木爪哇、gotu kola和temulawak联合输注对雄性Sprague Dawley (SD)大鼠的引种、攀爬、交媾水平和睾丸激素水平的影响。SD大鼠分为2组，对照组给予aquadest，治疗组给予爪哇(Talinum paniculatum)根、枸杞(Centella asiatica)草本、爪哇姜黄(Curcuma xanthorrhiza)根茎的合剂，剂量为491、2 mg/200 g BW，连续7 d。观察前48小时给予雌二醇2 mg/200 g BW诱导雌性SD大鼠人工发情。测定的参数是睾酮水平以及引入、攀爬和交媾频率。雌戊酸雌二醇可诱导雌性SD大鼠人工发情。联合输注剂量491.2 mg/200 g BW显著提高雄性SD大鼠睾酮水平，使雄性SD大鼠的睾酮水平和攀爬频率提高27.77%;分别为86.39%和69.17%。【摘要】虎尾虱(Talinum paniculatum)的secara empiris dan ilmiah terbukti telah banyak dimanfaatkan oleh masyarakat untuk mengatasi berbagai masalah kesehatan diantaranya untuk meningkatkan kualitas dan kuantitas)精子、再生细胞、生育能力、抗虎尾虱。Penelitian ini dilakukan untuk membuktikan efek peningkatan kadar激素睾丸激素serta frekuensis引进，攀爬，dan coitus tikus jantan SD dari pengaruh infusa kombinasi som jawa, pegagan, dan temulawak。河湾龙柏，雅图龙柏防治龙柏，沙当龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏，龙柏。黄芪发情人工黄芪黄芪雌二醇2 mg/200 g bb。参数阳diukur meliputi kadar睾酮，frekuensis介绍，攀爬，丹交媾。滇滇滇滇，滇滇滇滇，滇滇滇滇滇，滇滇滇滇滇，滇滇滇，27,77;86 39丹69 17%
{"title":"THE COMBINATION INFUSION OF Talinum paniculatum (Jacq.) Gaertn., Centella asiatica (L.) Urb. AND Curcuma xanthorrhiza Roxb. EFFECTS ON TESTOSTERONE LEVELS AND INTRODUCTION, CLIMBING AND COITUS FREQUENCIES IN MALE SPRAGUE-DAWLEY RATS","authors":"N. Rahmawati, I. Sholikhah","doi":"10.22435/jtoi.v12i1.1807","DOIUrl":"https://doi.org/10.22435/jtoi.v12i1.1807","url":null,"abstract":"ABSTRACT \u0000Talinum paniculatum (som Java) reported to have many pharmacological activities such as increasing spermatozoa quality, cell regenerations, fertility, and antibacterial effect both empirically and scientifically. This study aimed to prove the combination infusion effects of som Java, gotu kola, and temulawak on introduction, climbing, and coitus levels as well as testosterone levels in male Sprague Dawley (SD) rats. SD rats were divided into 2 groups, control group received aquadest, treatment group received formula a mixture of som java Talinum paniculatum) root, gotu kola (Centella asiatica) herb, and Javanese turmeric (Curcuma xanthorrhiza) rhizome with the dose of 491,2 mg/200 g BW for 7 consecutive days. Artificial estrus of female SD rats were induced by administering estradiol valerat 2 mg/200 g BW 48 hours before observation. The determined parameters were levels of testosterone as well as introduction, climbing and coitus frequencies. Administration of estradiol valerat led to artificial estrus induction of female SD rats. The administration of the combination infusion dose 491.2 mg/200 g BW significantly increased testosterone level as well as introduction and climbing frequencies of male SD rats as of 27.77%; 86.39% and 69.17% respectively. \u0000ABSTRAK \u0000Som jawa (Talinum paniculatum) secara empiris dan ilmiah terbukti telah banyak dimanfaatkan oleh masyarakat untuk mengatasi berbagai masalah kesehatan diantaranya untuk meningkatkan kualitas dan kuantitas spermatozoa, regenerasi sel, fertilitas, dan sebagai antibakteri. Penelitian ini dilakukan untuk membuktikan efek peningkatan kadar hormon testosteron serta frekuensi introduction, climbing, dan coitus tikus jantan SD dari pengaruh infusa kombinasi som jawa, pegagan, dan temulawak. Hewan uji tikus galur SD dibagi menjadi 2 kelompok, yaitu kelompok kontrol diberikan akuades, sedangkan kelompok perlakuan diberikan infusa ramuan akar som jawa, herba pegagan, dan rimpang temulawak dosis 491,2 mg/200 g bb selama 7 hari berturut-turut. Induksi estrus artifisial tikus betina dengan pemberian estradiol valerat 2 mg/200 g bb dilakukan 48 jam sebelum pengamatan. Parameter yang diukur meliputi kadar testosterone, frekuensi introduction, climbing, dan coitus. Dibandingkan dengan kelompok kontrol, pemberian infusa ramuan tidak berefek pada frekunsi coitus, namun mampu meningkatkan kadar testosteron serta frekuensi introduction dan climbing tikus jantan sebesar 27,77; 86,39 dan 69,17%. \u0000 \u0000 \u0000 \u0000 \u0000 ","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85426859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-30DOI: 10.22435/jtoi.v12i1.1078
Sofa Farida, Tofan Aries Mana, T. F. Dewi
ABSTRACT "Ramuan kebugaran" or Physical Improvement Herb is one results of Saintifikasi Jamu research that has been proven its efficacy through clinical research. The concoction herbs consists of Javanese turmeric rhizome, turmeric rhizome, meniran herbs and it was prepared as decoction. Herbs in the capsule dosage form is considered easier to consume and more appropriate in determining the dosage. This research aimed to study the right filler for capsule dosage form of “Ekstrak Ramuan Jamu Kebugaran” (ERJK) for fulfilling the quality requirements. The ERJK extraction is obtained by infundation method, the extract filtrate was added with fillers, dried, and powdered. The filler used was avicel 102 (ERJK-1), lactose (ERJK-2) and amylum (ERJK-3). The powders were tested for flowability, tapping indexes, and microorganism contamination tests. The capsules dosage form were tested for weight uniformity and disintegration time. The results of the ERJK-1, ERJK-2 and ERJK-3 quality parameters test showed the flow times were respectively 6.3, 7.8 and 5.8 seconds; the tapping indexes were 14.3, 15.35 and 13.0%; yeast count were 1.2, 2.85 and 2.95 col/g; the total plate count were 2.0; 1.0 and 1.0 col/g; capsul weight uniformity (mg) were 677.04±5.30 (CV: 0.78%); 663.95±8.54 (CV: 1.28%) and 678.38±4.93 (CV: 0.72%); capsul disintegration time (minute) were 25.60, 27.89 and 26.47. The evaluation of quality parameters shows that avicel 102 is the better filler of ERJK compared to lactose and amylum. ABSTRAK Ramuan kebugaran merupakan salah satu jamu hasil riset Saintifikasi Jamu yang efektifitas khasiatnya telah terbukti melalui uji klinik. Ramuan tersebut berupa simplisia rimpang temulawak, rimpang kunyit dan herba meniran dan disiapkan melalui proses perebusan. Ramuan dalam bentuk sediaan kapsul dipandang lebih mudah dikonsumsi dan lebih tepat dalam penentuan dosis. Tujuan penelitian ini adalah mengkaji bahan pengisi yang tepat untuk kapsul ekstrak ramuan jamu kebugaran (ERJK) yang memenuhi persyaratan kualitas. Ekstraksi ERJK dengan metode infundasi, filtrat ekstrak ditambahkan bahan pengisi, dikeringkan kemudian diserbuk. Pengisi yang digunakan adalah avicel 102 (ERJK-1), laktosa (ERJK-2) dan amilum (ERJK-3). Serbuk sampel dilakukan uji sifat alir, indeks pengetapan, serta uji cemaran mikroorganisme. Sediaan kapsul diuji keseragaman bobot dan waktu hancur. Hasil uji parameter kualitas ERJK-1, ERJK-2 dan ERJK-3 menunjukkan waktu alir berturut-turut 6,3, 7,8, dan 5,8 detik; indeks pengetapan berturut-turut 14,3, 15,4 dan 13,0%; angka Jamur berturut-turut 1,2, 2,85 dan 2,95 kol/g; angka lempeng total berturut-turut 2,0; 1,0 dan1,0 kol/g; keseragaman bobot kapsul (mg) berturut-turut 677,04±5,30 (CV: 0,78%), 663,95±8,54 (CV: 1,28%) dan 678,38±4,93 (CV: 0,72%); uji waktu hancur kapsul (menit) berturut-turut 25,60, 27,89 dan 26,47. Evaluasi parameter kualitas menunjukkan avicel 102 paling baik digunakan sebagai pengisi ERJK dibandingkan laktosa dan amilum.
【摘要】“健体药”是一种经临床研究证实其疗效的中药。该制剂由爪哇姜黄、姜黄、梅兰三种草药配制而成。胶囊剂型的草药被认为更容易食用，并且在确定剂量时更合适。本研究的目的是为了研究“拉曼加木”(ERJK)胶囊剂型的合适填充剂，以满足其质量要求。采用基入法提取ERJK，提取滤液加入填料，干燥，成粉。使用的填充物为avicel 102 (ERJK-1)、乳糖(ERJK-2)和淀粉(ERJK-3)。对粉末进行了流动性、攻丝指标和微生物污染检测。对胶囊剂型进行了重量均匀性和崩解时间的测定。ERJK-1、ERJK-2和ERJK-3质量参数测试结果显示，流动时间分别为6.3、7.8和5.8秒;挖掘指数分别为14.3、15.35和13.0%;酵母计数分别为1.2、2.85和2.95 col/g;总板数2.0;1.0和1.0 col/g;胶囊质量均匀度(mg)为677.04±5.30 (CV: 0.78%);663.95±8.54(简历:1.28%)和678.38±4.93(简历:0.72%);胶囊崩解时间分别为25.60、27.89和26.47分钟。质量参数评价表明，与乳糖和淀粉相比，avicel 102是更好的ERJK填料。ABSTRAK Ramuan kebugaran merupakan salah研究嘉姆hasil riset Saintifikasi嘉姆杨efektifitas khasiatnya telah terbukti melalui里头klinik。Ramuan tersebut berupa simplisia rimpang temulawak, rimpang kunyit和herbmeniran和disiapkan melaluis propro釜山。Ramuan dalam bentuk sediaan kapsul dipandang lebih mudah dikonsumsi danlebih tepat dalam pentuan dosis。图juan penelitian ini adalah mengkaji bahan pengisi yang tepat untuk kapsul ekstrak ramuan jamu kebugaran (ERJK) yang memenuhi persyaratan kualitas。[footnoteref: 1] [footnoteref: 1] [footnoteref: 1] [footnoteref: 1]。彭isi yang digunakan adalah avicel 102 (ERJK-1)， laktosa (ERJK-2)和amilum (ERJK-3)。Serbuk样品dilakukan uji sifat alir, indeks pengetapan, serta uji cemaran微生物。Sediaan kapsul diuji keseragaman bobot dan waktu hancur。Hasil uji参数kualitas ERJK-1, ERJK-2丹ERJK-3 menunjukkan waktu alir berturut-turut 6,3,7,8，丹5,8 detik;油墨pengetapan berturut-turut 14,3,15,4丹13,0%;angka Jamur berturut-turut 1、2、2、85、2、95 kol/g;Angka lempeng total berturut-turut 2 0;1、0µl/g;keseragaman bobot kapsul (mg) berturut-turut 677,04±5,30 (CV: 0.78%)， 663,95±8,54 (CV: 1.28%)和678,38±4,93 (CV: 0.72%);Uji waktu hancur kapsul (menit) berturut-turut 25,60,27,89 Dan 26,47。评价参数kualitas menunjukkan avicel 102 paling baik digunakan sebagai pengisi ERJK dibandingkan laktosa danilum。
{"title":"KARAKTERISTIK MUTU KAPSUL RAMUAN KEBUGARAN UNTUK SAINTIFIKASI JAMU","authors":"Sofa Farida, Tofan Aries Mana, T. F. Dewi","doi":"10.22435/jtoi.v12i1.1078","DOIUrl":"https://doi.org/10.22435/jtoi.v12i1.1078","url":null,"abstract":"ABSTRACT \u0000\"Ramuan kebugaran\" or Physical Improvement Herb is one results of Saintifikasi Jamu research that has been proven its efficacy through clinical research. The concoction herbs consists of Javanese turmeric rhizome, turmeric rhizome, meniran herbs and it was prepared as decoction. Herbs in the capsule dosage form is considered easier to consume and more appropriate in determining the dosage. This research aimed to study the right filler for capsule dosage form of “Ekstrak Ramuan Jamu Kebugaran” (ERJK) for fulfilling the quality requirements. The ERJK extraction is obtained by infundation method, the extract filtrate was added with fillers, dried, and powdered. The filler used was avicel 102 (ERJK-1), lactose (ERJK-2) and amylum (ERJK-3). The powders were tested for flowability, tapping indexes, and microorganism contamination tests. The capsules dosage form were tested for weight uniformity and disintegration time. The results of the ERJK-1, ERJK-2 and ERJK-3 quality parameters test showed the flow times were respectively 6.3, 7.8 and 5.8 seconds; the tapping indexes were 14.3, 15.35 and 13.0%; yeast count were 1.2, 2.85 and 2.95 col/g; the total plate count were 2.0; 1.0 and 1.0 col/g; capsul weight uniformity (mg) were 677.04±5.30 (CV: 0.78%); 663.95±8.54 (CV: 1.28%) and 678.38±4.93 (CV: 0.72%); capsul disintegration time (minute) were 25.60, 27.89 and 26.47. The evaluation of quality parameters shows that avicel 102 is the better filler of ERJK compared to lactose and amylum. \u0000ABSTRAK \u0000Ramuan kebugaran merupakan salah satu jamu hasil riset Saintifikasi Jamu yang efektifitas khasiatnya telah terbukti melalui uji klinik. Ramuan tersebut berupa simplisia rimpang temulawak, rimpang kunyit dan herba meniran dan disiapkan melalui proses perebusan. Ramuan dalam bentuk sediaan kapsul dipandang lebih mudah dikonsumsi dan lebih tepat dalam penentuan dosis. Tujuan penelitian ini adalah mengkaji bahan pengisi yang tepat untuk kapsul ekstrak ramuan jamu kebugaran (ERJK) yang memenuhi persyaratan kualitas. Ekstraksi ERJK dengan metode infundasi, filtrat ekstrak ditambahkan bahan pengisi, dikeringkan kemudian diserbuk. Pengisi yang digunakan adalah avicel 102 (ERJK-1), laktosa (ERJK-2) dan amilum (ERJK-3). Serbuk sampel dilakukan uji sifat alir, indeks pengetapan, serta uji cemaran mikroorganisme. Sediaan kapsul diuji keseragaman bobot dan waktu hancur. Hasil uji parameter kualitas ERJK-1, ERJK-2 dan ERJK-3 menunjukkan waktu alir berturut-turut 6,3, 7,8, dan 5,8 detik; indeks pengetapan berturut-turut 14,3, 15,4 dan 13,0%; angka Jamur berturut-turut 1,2, 2,85 dan 2,95 kol/g; angka lempeng total berturut-turut 2,0; 1,0 dan1,0 kol/g; keseragaman bobot kapsul (mg) berturut-turut 677,04±5,30 (CV: 0,78%), 663,95±8,54 (CV: 1,28%) dan 678,38±4,93 (CV: 0,72%); uji waktu hancur kapsul (menit) berturut-turut 25,60, 27,89 dan 26,47. Evaluasi parameter kualitas menunjukkan avicel 102 paling baik digunakan sebagai pengisi ERJK dibandingkan laktosa dan amilum. \u0000 ","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90459281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Chrysophyllum cainito L. is a plant which empirically used as traditional medicine. The pharmacological effect of C. cainito is caused by secondary metabolite activity contain in the leaves. The aim of this research was to know the metabolites profile in n-hexane extract, ethyl acetate extract, and methanol extract of C. cainito leaves using UPLC-QToF-MS/MS. Dried powder of C. cainito leaves was extracted with n-hexane, ethyl acetate, and methanol with gradual extraction using Ultrasonic Assisted Extraction (UAE). Each extract was prepared with methanol and DCM solvent then injected 5 µl into UPLC-QToF-MS/MS and analyzed with Masslynx 4.1 softwares and Chemspider. The result showed that there were 28 compounds from n-hexane extract with diethyltoluamide as major compound, 47 compounds from ethyl acetate extract with loliolide as major compound, and 34 compounds from methanol extract with eplerenone as major compound. Based on literature study, there were also several compounds that likely having activity as phytoestrogens. Keyword: Metabolite profiling, chrysophyllum cainito L., UPLC QToF-MS/MS ABSTRAK Chrysophyllum cainito L. merupakan tumbuhan yang secara empiris digunakan sebagai obat tradisional. Efek farmakologi tersebut disebabkan adanya aktivitas dari berbagai senyawa metabolit sekunder yang terkandung dalam daun C. cainito. Tujuan dari penelitian ini untuk mengetahui profil metabolit ekstrak n-heksana, ekstrak etil asetat, dan ekstrak metanol daun C. cainito menggunakan UPLC-QToF-MS/MS. Serbuk kering daun C. cainito diekstraksi secara bertingkat menggunakan n-heksana, etil asetat, dan metanol dengan metode UAE. Masing-masing ekstrak dipreparasi dengan metanol dan DCM lalu diinjeksikan sebanyak 5 µl ke dalam UPLC-QToF-MS/MS, kemudian dianalisis dengan software Masslynx 4.1 dan Chemspider. Hasil menunjukkan profil metabolit dari masing-masing ekstrak daun C. cainito, yaitu ekstrak n-heksana dengan 28 senyawa dan diethyltoluamide sebagai senyawa mayor, 47 senyawa terkandung dalam ekstrak etil asetat dengan senyawa mayor loliolide, dan 34 senyawa terkandung dalam ekstrak metanol dengan senyawa mayor yaitu eplerenone. Dari studi literatur diketahui terdapat beberapa senyawa yang memiliki aktivitas sebagai fitoestrogen. Kata Kunci: Metabolite profiling, Chrysophyllum cainito L., UPLC QToF-MS/MS
金菊(Chrysophyllum cainito L.)是一种传统药用植物。蛇藤的药理作用是由其叶片中含有的次生代谢物活性引起的。本研究采用UPLC-QToF-MS/MS方法，了解肉桂叶正己烷提取物、乙酸乙酯提取物和甲醇提取物的代谢产物谱。以正己烷、乙酸乙酯和甲醇为萃取剂，采用超声辅助萃取法(UAE)逐步提取茜草叶干粉。各提取液以甲醇和DCM溶剂配制，进样5µl UPLC-QToF-MS/MS，使用Masslynx 4.1软件和Chemspider进行分析。结果表明，以二乙基甲苯酰胺为主要化合物的正己烷提取物中有28个化合物，以油橄榄内酯为主要化合物的乙酸乙酯提取物中有47个化合物，以乙烯酮为主要化合物的甲醇提取物中有34个化合物。根据文献研究，也有几种化合物可能具有植物雌激素的活性。关键词:代谢物谱分析，金菊，UPLC, QToF-MS/MS研究结果表明，在杨氏菌群中，白藜芦醇的代谢作用与白藜芦醇的代谢作用是一致的。图juan dari penelitian, untutuk menggetahui剖面，代谢谱，代谢谱，代谢谱，代谢谱，代谢谱，代谢谱，代谢谱，代谢谱，代谢谱，代谢谱。Serbuk kering, C. cainito diekstraksi secara bertingkat menggunakan n . heksana, etil asetat, danmetodengan meuva。采用hplc - qtof -MS/MS /MS，采用化学分析软件Masslynx 4.1和Chemspider。Hasil menunjukkan剖面代谢dari masing-masing ekstrak daan C. cainito, yitu ekstrak n . heksana dengan 28 senyawa dan二乙基氨基sebagai senyawa mayor, 47 senyawa terkandung dalam ekstrak etil asetat dengan senyawa mayor loliolide, 34 senyawa terkandung dalam ekstrak甲醇dengan senyawa mayor yiteplerone。达利研究文献diketahui terdapat beberapa senyawa yang memoriliki aktivitas sebagai fitestrogen。Kata Kunci:金菊代谢物谱分析，UPLC QToF-MS/MS
{"title":"PROFIL METABOLIT BERBAGAI EKSTRAK DAUN Chrysophyllum cainito L. MENGGUNAKAN UPLC-QTOF-MS/MS","authors":"Burhan Ma’arif, Roihatul Muti’ah","doi":"10.22435/jtoi.v12i1.672","DOIUrl":"https://doi.org/10.22435/jtoi.v12i1.672","url":null,"abstract":"ABSTRACT \u0000Chrysophyllum cainito L. is a plant which empirically used as traditional medicine. The pharmacological effect of C. cainito is caused by secondary metabolite activity contain in the leaves. The aim of this research was to know the metabolites profile in n-hexane extract, ethyl acetate extract, and methanol extract of C. cainito leaves using UPLC-QToF-MS/MS. Dried powder of C. cainito leaves was extracted with n-hexane, ethyl acetate, and methanol with gradual extraction using Ultrasonic Assisted Extraction (UAE). Each extract was prepared with methanol and DCM solvent then injected 5 µl into UPLC-QToF-MS/MS and analyzed with Masslynx 4.1 softwares and Chemspider. The result showed that there were 28 compounds from n-hexane extract with diethyltoluamide as major compound, 47 compounds from ethyl acetate extract with loliolide as major compound, and 34 compounds from methanol extract with eplerenone as major compound. Based on literature study, there were also several compounds that likely having activity as phytoestrogens. \u0000Keyword: Metabolite profiling, chrysophyllum cainito L., UPLC QToF-MS/MS \u0000 \u0000 \u0000ABSTRAK \u0000Chrysophyllum cainito L. merupakan tumbuhan yang secara empiris digunakan sebagai obat tradisional. Efek farmakologi tersebut disebabkan adanya aktivitas dari berbagai senyawa metabolit sekunder yang terkandung dalam daun C. cainito. Tujuan dari penelitian ini untuk mengetahui profil metabolit ekstrak n-heksana, ekstrak etil asetat, dan ekstrak metanol daun C. cainito menggunakan UPLC-QToF-MS/MS. Serbuk kering daun C. cainito diekstraksi secara bertingkat menggunakan n-heksana, etil asetat, dan metanol dengan metode UAE. Masing-masing ekstrak dipreparasi dengan metanol dan DCM lalu diinjeksikan sebanyak 5 µl ke dalam UPLC-QToF-MS/MS, kemudian dianalisis dengan software Masslynx 4.1 dan Chemspider. Hasil menunjukkan profil metabolit dari masing-masing ekstrak daun C. cainito, yaitu ekstrak n-heksana dengan 28 senyawa dan diethyltoluamide sebagai senyawa mayor, 47 senyawa terkandung dalam ekstrak etil asetat dengan senyawa mayor loliolide, dan 34 senyawa terkandung dalam ekstrak metanol dengan senyawa mayor yaitu eplerenone. Dari studi literatur diketahui terdapat beberapa senyawa yang memiliki aktivitas sebagai fitoestrogen. \u0000Kata Kunci: Metabolite profiling, Chrysophyllum cainito L., UPLC QToF-MS/MS","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84318644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-29DOI: 10.22435/jtoi.v12i1.1266
Risha Fillah Fithria, R. Wulandari, D. Hidayati, Pia Annisa, Nilam Eka Putri
ABSTRACT Certain group of people empirically use peanut shell stew in the treatment of thrombocytopenia due to dengue fever. The active compounds suspected to play a role in the activity of thrombocytopenia from peanut shell are flavonoids. Flavonoids can be extracted using heat and cold methods. This study aims to determine the antithrombocytopenia activity of peanut shell extract and infusa on heparin induced Balb/C mice. This study is an experimental research with randomized matched pre and postest control group design. Peanut shell extraction was done in a cool way by maseration using 70% ethanol solvent, and hot way by infundation using aquadest solvent. Forty-eight Balb/C mice were divided into 8 groups consisting of control group CMC Na 0.5 mL/20gBW/day, control group aquadest 0,5mL/20gBW/day, 3 groups of peanut shell ethanol extract (0.019, 0.038, and 0.076) g/20gBW/day, and 3 groups of peanut shell infusa (0.026, 0.052; 0.104) g/20gBW/day. All treatments were given orally. The decrease of platelet count in Balb/C mice using 26 UI/20gBW subcutan heparin induction. The measurement of the platelet count is performed by taking blood samples in the lateral veins of the tail. Platelet counts data before and after treatment was tested with dependent T-test. Differences in platelet increases across the groups were tested by 2 way anova and continued with a LSD test with 95% confidence level. The results showed that peanut shell ethanol extract had better antitrombocytopenia activity than peanut shell infusa.
摘要:某组患者经验性应用花生壳炖汤治疗登革热所致血小板减少症。花生壳中被怀疑在血小板减少症活性中起作用的活性化合物是类黄酮。黄酮类化合物可采用冷热法提取。本研究旨在探讨花生壳提取物及浸出液对肝素诱导的Balb/C小鼠抗血小板减少的作用。本研究为随机匹配前后对照组设计的实验研究。花生壳的提取采用70%乙醇冷浸法，湿浸法热浸法。48只Balb/C小鼠分为8组，对照组CMC Na 0.5 mL/20gBW/day，对照组aquadest 0、5mL/20gBW/day，花生壳乙醇提取物3组(0.019、0.038、0.076)g/20gBW/day，花生壳浸出液3组(0.026、0.052;0.104) 20 g / gbw /天。所有治疗均为口服。26 μ u /20gBW皮下肝素诱导Balb/C小鼠血小板计数的减少。血小板计数的测量是通过在尾巴的侧静脉中采集血液样本来完成的。治疗前后血小板计数数据采用依赖t检验。各组间血小板增加的差异采用双因素方差分析检验，并继续采用95%置信水平的LSD检验。结果表明，花生壳乙醇提取物具有较好的抗血小板减少活性。
{"title":"ANTITHROMBOCYTOPENIA ACTIVITY OF PEANUT SHELL (Arachis hypogea L.) EXTRACT AND INFUSA ON HEPARIN INDUCED BALB/C MICE","authors":"Risha Fillah Fithria, R. Wulandari, D. Hidayati, Pia Annisa, Nilam Eka Putri","doi":"10.22435/jtoi.v12i1.1266","DOIUrl":"https://doi.org/10.22435/jtoi.v12i1.1266","url":null,"abstract":"ABSTRACT \u0000Certain group of people empirically use peanut shell stew in the treatment of thrombocytopenia due to dengue fever. The active compounds suspected to play a role in the activity of thrombocytopenia from peanut shell are flavonoids. Flavonoids can be extracted using heat and cold methods. This study aims to determine the antithrombocytopenia activity of peanut shell extract and infusa on heparin induced Balb/C mice. This study is an experimental research with randomized matched pre and postest control group design. Peanut shell extraction was done in a cool way by maseration using 70% ethanol solvent, and hot way by infundation using aquadest solvent. Forty-eight Balb/C mice were divided into 8 groups consisting of control group CMC Na 0.5 mL/20gBW/day, control group aquadest 0,5mL/20gBW/day, 3 groups of peanut shell ethanol extract (0.019, 0.038, and 0.076) g/20gBW/day, and 3 groups of peanut shell infusa (0.026, 0.052; 0.104) g/20gBW/day. All treatments were given orally. The decrease of platelet count in Balb/C mice using 26 UI/20gBW subcutan heparin induction. The measurement of the platelet count is performed by taking blood samples in the lateral veins of the tail. Platelet counts data before and after treatment was tested with dependent T-test. Differences in platelet increases across the groups were tested by 2 way anova and continued with a LSD test with 95% confidence level. The results showed that peanut shell ethanol extract had better antitrombocytopenia activity than peanut shell infusa.","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79318972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-21DOI: 10.22435/JTOI.V11I2.1003
Arif Setiawansyah, A. Hakim, D. G. Wirasisya
ABSTRACT Neem (Azadirachta indica A.Juss) is a plant that potentially developed for antibacterial agent for both the leaves and barks. The aims of this study were to compare the effectiveness of the antibacterial activity of neem leav es and stem barks extract and to identify the antibacterial compounds of the most active fractions. The extraction method was done using sonication method. Antibacterial activity was evaluated using wells solid diffusion method and TLC-Bioautography. Extract fractionation was conducted using liquid-liquid partitioning method. The chemical compounds of extracts and fractions were analyzed using TLC and GCMS. The result of sonication extraction obtained neem leaves oil (12,02%), leaves crude extract (4,3%) and stem barks crude extract (16,85%). The major chemical constituents of GCMS analysis are 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (6,06%), L-proline,1-Acetyl-(CAS) Acetylproline (5,85%), 4-hydroxy-2-methyl-pyrrolidine-2-carboxylic acid (21,42%), 2,3-Dyhidrobenzofuran (2,69%), alpha-D-methylglucopyranoside (4,54%), palmitic acid (2,92%), Arabino-hex-1-enitol, 1,5-Anhydro-2-deoxy-(CAS) glucal (31,69%). Phytochemical screening of neem leaves oil, leaves and barks crude extract revealed the presence of alkaloids, flavonoids, phenols, saponins, triterpenoids, steroids and sterols. Antibacterial test results showed neem leaves oil was more effective than leaves and stem barks crude extract against Escherichia coli. The n-hexane fraction showed higher antibacterial activity than ethyl acetate fraction and ethanol fraction. Phytochemical screening of n-hexane fraction showed the presence of triterpenoids, steroids, sterols and phenols. Mimba (Azadirachta indica A.Juss) merupakan tanaman yang berpotensi dikembangkan sebagai antibakteri baik bagian daun maupun kulit batang. Penelitian ini bertujuan untuk membandingkan efektivitas antibakteri ekstrak daun dan kulit batang mimba terhadap Escherichia coli dan untuk mengidentifikasi golongan senyawa potensial antibakteri pada fraksi teraktif. Pengujian aktivitas antibakteri dilakukan dengan metode difusi padat menggunakan sumuran dan KLT-Bioautografi. Fraksinasi ekstrak dilakukan dengan metode partisi. Komponen kimia ekstrak dan fraksi dianalisis menggunakan KLT dan GCMS. Hasil ekstraksi sonikasi diperoleh minyak daun (12,02%), ekstrak kasar daun (4,3%) dan ekstrak kasar kulit batang (16,85%). Skrining fitokimia menunjukkan minyak daun, ekstrak kasar daun dan ekstrak kulit batang mimba mengandung senyawa alkaloid, flavonoid, fenolik, saponin, triterpenoid, steroid dan sterol. Komponen kimia mayor hasil analisis GCMS minyak daun mimba adalah 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (6,06%), L-proline,1-Acetyl-(CAS)Acetylproline (5,85%), 4-hydroxy-2-methyl-pyrrolidine-2-carboxylic acid (21,42%), 2,3-dyhidrobenzofuran (2,69%), Alpha-d-methylglucopyranoside (4,54%), Asam Palmitat (2,92%), Arabino-hex-1-enitol, 1,5-anhydro-2-deoxy-(CAS)glucal (31,69%). Hasil
印楝(Azadirachta indica a . juss)是一种极具开发潜力的植物。本研究的目的是比较印楝叶和茎皮提取物的抑菌活性，并鉴定最有效的抑菌化合物。提取方法采用超声法。采用井固扩散法和薄层色谱-生物自显影法评价其抑菌活性。提取液采用液-液分馏法进行分馏。采用薄层色谱(TLC)和气相色谱(GCMS)分析提取物和馏分的化学成分。超声提取得到印楝叶油(12.02%)、叶粗提物(4.3%)和茎皮粗提物(16.85%)。GCMS分析的主要化学成分为2,3-二氢-3,5-二羟基-6-甲基-4- h -吡喃-4-酮(6,06%)，l-脯氨酸，1-乙酰基-(CAS)乙酰脯氨酸(5,85%)，4-羟基-2-甲基吡咯烷-2-羧酸(21,42%)，2,3-二氢苯并呋喃(2,69%)，α -d -甲基葡萄糖苷(4,54%)，棕榈酸(2,92%)，阿拉伯-己-1-烯醇，1,5-无羟基-2-脱氧-(CAS)葡萄糖(31,69%)。对印楝叶油、叶皮粗提物进行植物化学筛选，发现其含有生物碱、类黄酮、酚类、皂苷、三萜、甾体和甾醇。抑菌试验结果表明，印楝叶油对大肠杆菌的抑菌效果优于叶、茎皮粗提物。正己烷部位的抑菌活性高于乙酸乙酯部位和乙醇部位。正己烷馏分的植物化学筛选结果显示含有三萜、甾体、甾醇和酚类化合物。米巴(Azadirachta indica A.Juss) merupakan tanaman yang berpotensi dikembangkan sebagai antibakteri baik bagian daum maupun kulit batang。Penelitian ini bertujuan untuk研究结果表明，该菌株具有抗细菌活性，并具有抗细菌活性，同时具有抗细菌活性。企鹅活性物，抗细菌，迪拉库坎，登根，方法，扩散，蒙古纳坎，苏木兰，klt -生物自传。我的意思是，我的意思是，我的意思是，我的意思是。Komponen kimia ekstrak和frakakan分析，menggunakan KLT和GCMS。Hasil ekstraksi sonikasi diperoleh minyak daun (12.02%)， ekstrak kasar daun(4.3%)和ekstrak kasar kulit batang(16.85%)。生物碱、类黄酮、茴香醚、皂苷、三萜、甾烷甾醇。Komponen kimia mayor hasil分析GCMS minyak dawn mimba adalah 2,3-二氢-3,5-二羟基-6-甲基-4- h -吡喃-4-酮(6,06%)，l-脯氨酸，1-乙酰基-(CAS)乙酰脯氨酸(5,85%)，4-羟基-2-甲基吡咯烷-2-羧酸(21,42%)，2,3-二氢苯并呋喃(2,69%)，α -d-甲基吡喃葡萄糖苷(4,54%)，Asam Palmitat (2,92%)， arabino -己-1-烯醇，1,5-无氢-2-脱氧-(CAS)葡萄糖(31,69%)。哈西尔乌吉抗细菌剂menunjukkan minykkan和lebih的作用，孟山都，孟山都，pertumbuhan大肠杆菌，dibandingkan dengan ekstrak kasar和dan kulit batang。三种抗细菌活性物质的研究表明:一种抗细菌活性物质，一种抗细菌活性物质，一种抗细菌活性物质。Hasil skining fitokia fraksi n-heksan menunjukkan adanya senyawa三萜，类固醇，甾醇和fenolik。
{"title":"EVALUASI DAN IDENTIFIKASI GOLONGAN SENYAWA POTENSIAL ANTIBAKTERI PADA DAUN DAN KULIT BATANG MIMBA (Azhadirachta indica A. Juss) TERHADAP Escherichia coli","authors":"Arif Setiawansyah, A. Hakim, D. G. Wirasisya","doi":"10.22435/JTOI.V11I2.1003","DOIUrl":"https://doi.org/10.22435/JTOI.V11I2.1003","url":null,"abstract":"ABSTRACT \u0000Neem (Azadirachta indica A.Juss) is a plant that potentially developed for antibacterial agent for both the leaves and barks. The aims of this study were to compare the effectiveness of the antibacterial activity of neem leav es and stem barks extract and to identify the antibacterial compounds of the most active fractions. The extraction method was done using sonication method. Antibacterial activity was evaluated using wells solid diffusion method and TLC-Bioautography. Extract fractionation was conducted using liquid-liquid partitioning method. The chemical compounds of extracts and fractions were analyzed using TLC and GCMS. The result of sonication extraction obtained neem leaves oil (12,02%), leaves crude extract (4,3%) and stem barks crude extract (16,85%). The major chemical constituents of GCMS analysis are 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (6,06%), L-proline,1-Acetyl-(CAS) Acetylproline (5,85%), 4-hydroxy-2-methyl-pyrrolidine-2-carboxylic acid (21,42%), 2,3-Dyhidrobenzofuran (2,69%), alpha-D-methylglucopyranoside (4,54%), palmitic acid (2,92%), Arabino-hex-1-enitol, 1,5-Anhydro-2-deoxy-(CAS) glucal (31,69%). Phytochemical screening of neem leaves oil, leaves and barks crude extract revealed the presence of alkaloids, flavonoids, phenols, saponins, triterpenoids, steroids and sterols. Antibacterial test results showed neem leaves oil was more effective than leaves and stem barks crude extract against Escherichia coli. The n-hexane fraction showed higher antibacterial activity than ethyl acetate fraction and ethanol fraction. Phytochemical screening of n-hexane fraction showed the presence of triterpenoids, steroids, sterols and phenols. \u0000 \u0000Mimba (Azadirachta indica A.Juss) merupakan tanaman yang berpotensi dikembangkan sebagai antibakteri baik bagian daun maupun kulit batang. Penelitian ini bertujuan untuk membandingkan efektivitas antibakteri ekstrak daun dan kulit batang mimba terhadap Escherichia coli dan untuk mengidentifikasi golongan senyawa potensial antibakteri pada fraksi teraktif. Pengujian aktivitas antibakteri dilakukan dengan metode difusi padat menggunakan sumuran dan KLT-Bioautografi. Fraksinasi ekstrak dilakukan dengan metode partisi. Komponen kimia ekstrak dan fraksi dianalisis menggunakan KLT dan GCMS. Hasil ekstraksi sonikasi diperoleh minyak daun (12,02%), ekstrak kasar daun (4,3%) dan ekstrak kasar kulit batang (16,85%). Skrining fitokimia menunjukkan minyak daun, ekstrak kasar daun dan ekstrak kulit batang mimba mengandung senyawa alkaloid, flavonoid, fenolik, saponin, triterpenoid, steroid dan sterol. Komponen kimia mayor hasil analisis GCMS minyak daun mimba adalah 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (6,06%), L-proline,1-Acetyl-(CAS)Acetylproline (5,85%), 4-hydroxy-2-methyl-pyrrolidine-2-carboxylic acid (21,42%), 2,3-dyhidrobenzofuran (2,69%), Alpha-d-methylglucopyranoside (4,54%), Asam Palmitat (2,92%), Arabino-hex-1-enitol, 1,5-anhydro-2-deoxy-(CAS)glucal (31,69%). Hasil ","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74820118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hiperurisemia merupakan suatu keadaan dimana terjadi peningkatan kadar asam urat darah melebihi nilai normal. Cabe jawa (Piper retrofractum), daun sendok (Plantago major), dan seledri (Avium graveolens) diketahui memiliki khasiat sebagai penurun asam urat darah. Penggunaan kombinasi ketiga tanaman obat tersebut sebagai anti hiperurisemia belum pernah dilakukan sebelumnya. Penelitian ini bertujuan untuk menentukan khasiat ketiga tanaman tersebut dalam satu ramuan jamu. Jenis penelitian ini adalah eksperimental murni dengan pre and post test controlled design. Hasil intervensi selama 7 hari pada 30 ekor tikus putih jantan yang terbagi dalam 5 kelompok yakni kelompok kontrol (tanpa perlakuan), kelompok kontrol positif (allopurinol), kelompok ramuan jamu dengan 3 macam dosis masing-masing 0,2 g, 0,4 g dan 0,8 g, menunjukan bahwa kadar asam urat darah pada kelompok perlakuan mengalami penurunan. Pemberian ramuan jamu anti hiperurisemia dengan dosis 0,4 g mampu menurunkan kadar asam urat darah dengan rerata paling tinggi. Ramuan jamu yang terdiri dari cabe jawa, daun sendok dan seledri mampu menurunkan kadar asam urat darah pada tikus. Kata kunci: Cabe jawa, daun sendok, seledri, hiperurisemia
甲状腺机能减退是一种尿酸水平高于正常水平的情况。java辣椒(Piper逆时针)、匙叶(plangos graveolens)和芹菜(Avium graveolens)具有退行性。使用草药的第三种组合作为抗黄疸的前期药物。这项研究的目的是确定三种草药的疗效。这类研究是纯实验的，有预试验和后测设计。干预结果30日七天的雄性白老鼠的尾巴,分成5组是对照组(没有积极的待遇),对照组(allopurinol),草药和三种剂量组每人0.2,0.4 g g和0.8 g,显示组的血尿酸水平下降待遇。用0.4克(0.25盎司)的抗过敏草药注射，可以用最高的平均尿酸降低尿酸水平。由java辣椒、茶匙叶和芹菜组成的草药可以降低老鼠的尿酸水平。关键词:java辣椒，茶匙叶，芹菜，hi秘鲁
{"title":"AKTIFITAS RAMUAN JAMU CABE JAWA, DAUN SENDOK DAN SELEDRI TERHADAP TIKUS HIPERURISEMIA","authors":"Ulfa Fitriani, Enggar Wijayanti, Zuraida Zulkarnain","doi":"10.22435/JTOI.V11I2.535","DOIUrl":"https://doi.org/10.22435/JTOI.V11I2.535","url":null,"abstract":"Hiperurisemia merupakan suatu keadaan dimana terjadi peningkatan kadar asam urat darah melebihi nilai normal. Cabe jawa (Piper retrofractum), daun sendok (Plantago major), dan seledri (Avium graveolens) diketahui memiliki khasiat sebagai penurun asam urat darah. Penggunaan kombinasi ketiga tanaman obat tersebut sebagai anti hiperurisemia belum pernah dilakukan sebelumnya. Penelitian ini bertujuan untuk menentukan khasiat ketiga tanaman tersebut dalam satu ramuan jamu. Jenis penelitian ini adalah eksperimental murni dengan pre and post test controlled design. Hasil intervensi selama 7 hari pada 30 ekor tikus putih jantan yang terbagi dalam 5 kelompok yakni kelompok kontrol (tanpa perlakuan), kelompok kontrol positif (allopurinol), kelompok ramuan jamu dengan 3 macam dosis masing-masing 0,2 g, 0,4 g dan 0,8 g, menunjukan bahwa kadar asam urat darah pada kelompok perlakuan mengalami penurunan. Pemberian ramuan jamu anti hiperurisemia dengan dosis 0,4 g mampu menurunkan kadar asam urat darah dengan rerata paling tinggi. Ramuan jamu yang terdiri dari cabe jawa, daun sendok dan seledri mampu menurunkan kadar asam urat darah pada tikus. \u0000 \u0000Kata kunci: Cabe jawa, daun sendok, seledri, hiperurisemia","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82606230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Medicinal plants for health effort and diseases treatment has been used by ethnic groups in South Sulawesi for years. One of them is for diarrhea treatment. South Sulawesi is one of the top five provinces with the highest incidence and period prevalence of diarrhea in Indonesia. The purpose of this study was to investigate the species of medicinal plants used by traditional healer in South Sulawesi for anti-diarrhea and their scientific evidence. The data was obtained from the exploration of local ethnomedicin knowledge and medicinal plant based on community in Indonesia in 2012-2015 and 2017. The data was analyzed to find out the fidelity level, used value (UV), choice value (CV), and factor of informant’s consensus (FIc). The result reported information about thirty medicinal plants used for diarrhea treatment, including the plants name, part used, and preparation method that obtained from 48 traditional healer of 19 ethnic groups in South Sulawesi. The fidelity level were 41,67% for Psidium guajava, 8,33% for Mangifera sp, 6,25% for Curcuma domestica and C. Zedoaria, 4,17% for Allium cepa, Anacardium officinale, Syzigium cumini, and C.xanthorrhiza. The highest UV and CV were 0,42 and 13,84 for Psidium guajava. The informant’s consensus of medicinal plant for diarrhea treatment was 0,38. The commonly used parts was the leaves and most of the used methods were administered orally. The conclusions of this study were ethnic groups in South Sulawesi has various formula of medicinal plants for diarrhea treatment, but P.guajava was the most commonly used. Those formulas information for diarrhea treatment would be an alternative to overcome diarrhea problems in South Sulawesi. Key words: medicinal plant, traditional healer, diarrhea, ABSTRAK Pengetahuan lokal dalam pemanfaatan tumbuhan obat untuk mencegah dan mengatasi penyakit telah dimiliki secara turun temurun oleh etnis-etnis di Sulawesi Selatan. Salah satunya adalah untuk mengatasi diare. Sulawesi Selatan termasuk dalam lima provinsi dengan insiden maupun period prevalence diare tertinggi di Indonesia. Tujuan dari penelitian ini adalah untuk mengungkap jenis-jenis tumbuhan obat yang digunakan hatttra di Sulawesi Selatan dalam ramuan anti diare dan bukti ilmiah penggunaan tanaman obat tersebut untuk mengatasi diare. Studi ini menggunakan data sekunder yang diperoleh dari Eksplorasi pengetahuan lokal etnomedisin dan tumbuhan obat berbasis komunitas di Indonesia pada tahun 2012,2015 dan 2017. Analisis data dilakukan untuk mengetahui Fidelity level, Used value, Choice value, Factor of informant’s consensus dan studi referensi ilmiahnya. Hasil studi menunjukkan informasi tentang tiga puluh tanaman obat untuk mengatasi diare yang diperoleh dari 48 penyehat tradisional yang berasal dari 19 etnis di Sulawesi Selatan. Informasi tersebut termasuk nama tanaman, bagian yang digunakan, dan metode persiapan. Fidelity level yang tertinggi adalah 41,67% untuk Psidium guajava, disusul 8,33%
药用植物用于保健和疾病治疗已被南苏拉威西民族使用多年。其中一个是治疗腹泻的。南苏拉威西是印度尼西亚腹泻发病率和流行期最高的五个省份之一。本研究的目的是调查南苏拉威西传统治疗师用于抗腹泻的药用植物种类及其科学依据。数据来源于2012-2015年和2017年印度尼西亚当地基于社区的民族医学知识和药用植物的探索。对数据进行分析，找出保真度水平、使用值(UV)、选择值(CV)和举报人共识因子(FIc)。结果报告了从南苏拉威西19个民族的48位传统治疗师处获得的30种治疗腹泻的药用植物的植物名称、使用部位、制备方法等信息。番石榴的保真度为41.67%，芒果的保真度为8.33%，家麻和莪术的保真度为6.25%，葱、铁皮心、木犀草和黄芩的保真度为4.17%。番石榴紫荆的UV和CV最高，分别为0.42和13.84。被调查者对治疗腹泻的药用植物的共识为0.38。常用部位为叶，多采用口服给药。本研究的结论是南苏拉威西少数民族有各种配方的药用植物用于治疗腹泻，但瓜爪哇是最常用的。这些用于腹泻治疗的配方信息将是克服南苏拉威西岛腹泻问题的另一种选择。【关键词】药用植物，传统治疗师，腹泻，摘要:彭格塔环当地的dalam pemanfaatan tumbuhan obat untuk menegah dan mengatasi penyakit telah dimiliki secara turun temurun oleh etnis di Sulawesi Selatan。Salah satunya adalah untuk mengatasi diare。苏拉威西，西拉丹，特马苏克，达拉姆，利马省，登吉安，在maupun时期，流行趋势在印度尼西亚。在苏拉威西，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿，我的女儿。研究:云南云南地区的数据，根据云南云南地区的地理分布，云南云南地区的地理分布，云南云南地区的地理分布，云南云南地区的地理分布，1992,2015,2017,2017。分析数据的差异，包括忠诚度水平、使用价值、选择价值、举报人共识因素和研究参考因素等。苏拉威西西拉西岛的传统文化，传统文化，传统文化，传统文化，传统文化，传统文化。Informasi tersebut termasuk nama tanaman, bagian yang digunakan, dan metode japan。保真度等级为杨廷芝41,67%番石榴，8,33%芒果，6,25%姜黄和莪术，4,17%葱，金菖蒲，金菖蒲，黄根茎。[4]李海峰，李海峰，李海峰，等。“共识”的信息是，在2010年，在中国，在中国，在中国。Bagian yang umum digunakan adalah dansebagian besar cara pemakaian dengan minium。Dari hasil tersebut dapat dispulpulkan bahwa kelompok etnis di Sulawesi Selatan memiliki berbagai formula tanaman obat untuk mengatasi diare, tetapi P.guajava adalah yang paling banyak digunakan。信息公式untuk mengatasi diare diharapkan dapat menjadi alternaftuk masalah diare di Sulawesi Selatan。Kata kunci: tumbuhan obat, penyehat traditional, diare
{"title":"STUDI ETNOFARMAKOLOGI TUMBUHAN OBAT YANG DIGUNAKAN OLEH PENYEHAT TRADISIONAL UNTUK MENGATASI DIARE DI SULAWESI SELATAN","authors":"Fanie Indrian Mustofa, Nuning Rahmawati","doi":"10.22435/jtoi.v11i2.580","DOIUrl":"https://doi.org/10.22435/jtoi.v11i2.580","url":null,"abstract":"ABSTRACT \u0000Medicinal plants for health effort and diseases treatment has been used by ethnic groups in South Sulawesi for years. One of them is for diarrhea treatment. South Sulawesi is one of the top five provinces with the highest incidence and period prevalence of diarrhea in Indonesia. The purpose of this study was to investigate the species of medicinal plants used by traditional healer in South Sulawesi for anti-diarrhea and their scientific evidence. The data was obtained from the exploration of local ethnomedicin knowledge and medicinal plant based on community in Indonesia in 2012-2015 and 2017. The data was analyzed to find out the fidelity level, used value (UV), choice value (CV), and factor of informant’s consensus (FIc). The result reported information about thirty medicinal plants used for diarrhea treatment, including the plants name, part used, and preparation method that obtained from 48 traditional healer of 19 ethnic groups in South Sulawesi. The fidelity level were 41,67% for Psidium guajava, 8,33% for Mangifera sp, 6,25% for Curcuma domestica and C. Zedoaria, 4,17% for Allium cepa, Anacardium officinale, Syzigium cumini, and C.xanthorrhiza. The highest UV and CV were 0,42 and 13,84 for Psidium guajava. The informant’s consensus of medicinal plant for diarrhea treatment was 0,38. The commonly used parts was the leaves and most of the used methods were administered orally. The conclusions of this study were ethnic groups in South Sulawesi has various formula of medicinal plants for diarrhea treatment, but P.guajava was the most commonly used. Those formulas information for diarrhea treatment would be an alternative to overcome diarrhea problems in South Sulawesi. \u0000 \u0000Key words: medicinal plant, traditional healer, diarrhea, \u0000 \u0000ABSTRAK \u0000Pengetahuan lokal dalam pemanfaatan tumbuhan obat untuk mencegah dan mengatasi penyakit telah dimiliki secara turun temurun oleh etnis-etnis di Sulawesi Selatan. Salah satunya adalah untuk mengatasi diare. Sulawesi Selatan termasuk dalam lima provinsi dengan insiden maupun period prevalence diare tertinggi di Indonesia. Tujuan dari penelitian ini adalah untuk mengungkap jenis-jenis tumbuhan obat yang digunakan hatttra di Sulawesi Selatan dalam ramuan anti diare dan bukti ilmiah penggunaan tanaman obat tersebut untuk mengatasi diare. Studi ini menggunakan data sekunder yang diperoleh dari Eksplorasi pengetahuan lokal etnomedisin dan tumbuhan obat berbasis komunitas di Indonesia pada tahun 2012,2015 dan 2017. Analisis data dilakukan untuk mengetahui Fidelity level, Used value, Choice value, Factor of informant’s consensus dan studi referensi ilmiahnya. Hasil studi menunjukkan informasi tentang tiga puluh tanaman obat untuk mengatasi diare yang diperoleh dari 48 penyehat tradisional yang berasal dari 19 etnis di Sulawesi Selatan. Informasi tersebut termasuk nama tanaman, bagian yang digunakan, dan metode persiapan. Fidelity level yang tertinggi adalah 41,67% untuk Psidium guajava, disusul 8,33% ","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84314335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Javanese turmeric (Curcuma xanthorrhiza Roxb.) is a medicinal plant that can be developed for the treatment of liver disease. The aim of this study is to evaluate the decoction of fresh rhizome, decoction of dried rhizome, essential oils, and curcumin of Curcuma xanthorrhiza Roxb. against bilirubin level on paracetamol-induced male Wistar rats. Male Wistar rats were divided into 10 groups including group I and II were normal control and negative control, groups III, IV, and V received pretreatment of decoction of fresh rhizome 0,75 g/kgBW, 2,25 g/kgBW, and 6,75 g/kgBW, respectively for 9 days, Groups VI, VII, and VIII received pretreatment of decoction of dried rhizome 0,45 g/kgBW, 1,35 g/kgBW, and 4,05 g/kgBW, respectively for 9 days, group IX received pretreatment of essential oils 1,01 μl/kgBW for 9 days, group X received pretreatment of curcumin 75 μg/kgBW for 9 days. Groups II, III, IV, V, VI, VII, VIII, IX, and X on days 7, 8, and 9 induced paracetamol 3 g/kgBW. The blood was drained on day 0 and 4 after induction of paracetamol for bilirubin parameter study. Data were analyzed statistically using One-Way ANOVA test followed by LSD test with a 95% confidence level. The results showed that pretreatment of decoction of fresh rhizome 0,75 g/kgBW decrease the bilirubin level significantly (p<0,05) against the negative control. It can be concluded that pretreatment of decoction of fresh rhizome 0,75 g/kgBW was the best effect of decrease the bilirubin level.
{"title":"EFEK REBUSAN RIMPANG SEGAR, REBUSAN RIMPANG KERING, MINYAK ATSIRI DAN KURKUMIN Curcuma xanthorriza Roxb. TERHADAP KADAR BILIRUBIN PADA TIKUS WISTAR JANTAN YANG DIINDUKSI PARASETAMOL","authors":"F. Arifah, S. Pramono, A. Nugroho","doi":"10.22435/jtoi.v11i2.572","DOIUrl":"https://doi.org/10.22435/jtoi.v11i2.572","url":null,"abstract":"Javanese turmeric (Curcuma xanthorrhiza Roxb.) is a medicinal plant that can be developed for the treatment of liver disease. The aim of this study is to evaluate the decoction of fresh rhizome, decoction of dried rhizome, essential oils, and curcumin of Curcuma xanthorrhiza Roxb. against bilirubin level on paracetamol-induced male Wistar rats. Male Wistar rats were divided into 10 groups including group I and II were normal control and negative control, groups III, IV, and V received pretreatment of decoction of fresh rhizome 0,75 g/kgBW, 2,25 g/kgBW, and 6,75 g/kgBW, respectively for 9 days, Groups VI, VII, and VIII received pretreatment of decoction of dried rhizome 0,45 g/kgBW, 1,35 g/kgBW, and 4,05 g/kgBW, respectively for 9 days, group IX received pretreatment of essential oils 1,01 μl/kgBW for 9 days, group X received pretreatment of curcumin 75 μg/kgBW for 9 days. Groups II, III, IV, V, VI, VII, VIII, IX, and X on days 7, 8, and 9 induced paracetamol 3 g/kgBW. The blood was drained on day 0 and 4 after induction of paracetamol for bilirubin parameter study. Data were analyzed statistically using One-Way ANOVA test followed by LSD test with a 95% confidence level. The results showed that pretreatment of decoction of fresh rhizome 0,75 g/kgBW decrease the bilirubin level significantly (p<0,05) against the negative control. It can be concluded that pretreatment of decoction of fresh rhizome 0,75 g/kgBW was the best effect of decrease the bilirubin level.","PeriodicalId":17794,"journal":{"name":"Jurnal Tumbuhan Obat Indonesia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77383493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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