Ajet Soleymani khezerabad, S. H. Delavar, H. Rashidi, M. Ghahramani
Background and Objectives Iron overload is seen in various tissues, including the pancreas, liver, and muscles in type 2 diabetes. The aim of the present study was to investigate the effect of high-intensity BodyPump training on indicators related to iron stores and blood glycemic control in women with type 2 diabetes. Subjects and Methods In the present quasi-experimental study, 20 women with type 2 diabetes were randomly selected and divided into two groups: BodyPump and control. BodyPump training was done for eight weeks, three sessions per week and each training session included 90-60 minutes of moderateintensity BodyPump training (75-80% of the reserve heart rate). Fasting blood sampling was performed before and after the intervention period. For statistical analysis, the paired sample t-test and independent t-test were used at a significance level of P≤0.05. Results The results of the present study showed that BodyPump significantly reduced glycosylated hemoglobin (P<0.001), insulin resistance (P<0.001), serum iron (P=0.041), and ferritin (P=0.019) compared to the control group. Conclusion BodyPump training may reduce excess iron in pancreatic, liver, and muscle tissues by modulating iron and ferritin stores, resulting in reduced insulin resistance, which causes glycemic control in women with type 2 diabetes.
{"title":"The Effect of Adjusting Iron Stores on Glycemic Control in Adaptation to Bodypump Training","authors":"Ajet Soleymani khezerabad, S. H. Delavar, H. Rashidi, M. Ghahramani","doi":"10.32598/jsmj.21.3.2819","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2819","url":null,"abstract":"Background and Objectives Iron overload is seen in various tissues, including the pancreas, liver, and muscles in type 2 diabetes. The aim of the present study was to investigate the effect of high-intensity BodyPump training on indicators related to iron stores and blood glycemic control in women with type 2 diabetes. Subjects and Methods In the present quasi-experimental study, 20 women with type 2 diabetes were randomly selected and divided into two groups: BodyPump and control. BodyPump training was done for eight weeks, three sessions per week and each training session included 90-60 minutes of moderateintensity BodyPump training (75-80% of the reserve heart rate). Fasting blood sampling was performed before and after the intervention period. For statistical analysis, the paired sample t-test and independent t-test were used at a significance level of P≤0.05. Results The results of the present study showed that BodyPump significantly reduced glycosylated hemoglobin (P<0.001), insulin resistance (P<0.001), serum iron (P=0.041), and ferritin (P=0.019) compared to the control group. Conclusion BodyPump training may reduce excess iron in pancreatic, liver, and muscle tissues by modulating iron and ferritin stores, resulting in reduced insulin resistance, which causes glycemic control in women with type 2 diabetes.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84324920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Safar Safarzadeh Gargari, A. Tofighi, Afshar Jafari, Javad Tolouei Azar, Fershte Farajdokht
Background and Objectives The role of stress oxidative on cardiac disease prevalence has been studied by researchers and the effects of high-intensity interval training (HIIT) have not been specified clearly. Therefore, the aim of this study was to investigate the effects of HIIT training with caffeine consumption on myocardial oxidative stress in rats. Subjects and Methods Thirty-two male rats were randomly divided into four groups (eight rats per group): control, HIIT (TA), caffeine (CA), and HIIT + caffeine (TA+CA). One hour before exercise, caffeine was injected into the CA and TA+CA groups. HIIT was performed five days a week with 85-90% maximum running speed on a treadmill for eight weeks. Then, 48 hr after the last exercise session and anaesthetization, the left ventricular was removed and the superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels were measured by spectrophotometry. Results The results indicated that MDA levels in the CA+TA and CA groups significantly decreased compared to the control group (P<0.05). Also, the levels of SOD and CAT significantly increased in the three groups compared to the control group. Conclusion HIIT along with caffeine consumption can protect the cardiac tissue in rats and prevent heart injury.
{"title":"The Effect of Caffeine Supplementation and High Intensity Interval Training on Myocardial Oxidation Stress in Male Wistar Rats","authors":"Safar Safarzadeh Gargari, A. Tofighi, Afshar Jafari, Javad Tolouei Azar, Fershte Farajdokht","doi":"10.32598/jsmj.21.3.2760","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2760","url":null,"abstract":"Background and Objectives The role of stress oxidative on cardiac disease prevalence has been studied by researchers and the effects of high-intensity interval training (HIIT) have not been specified clearly. Therefore, the aim of this study was to investigate the effects of HIIT training with caffeine consumption on myocardial oxidative stress in rats. Subjects and Methods Thirty-two male rats were randomly divided into four groups (eight rats per group): control, HIIT (TA), caffeine (CA), and HIIT + caffeine (TA+CA). One hour before exercise, caffeine was injected into the CA and TA+CA groups. HIIT was performed five days a week with 85-90% maximum running speed on a treadmill for eight weeks. Then, 48 hr after the last exercise session and anaesthetization, the left ventricular was removed and the superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels were measured by spectrophotometry. Results The results indicated that MDA levels in the CA+TA and CA groups significantly decreased compared to the control group (P<0.05). Also, the levels of SOD and CAT significantly increased in the three groups compared to the control group. Conclusion HIIT along with caffeine consumption can protect the cardiac tissue in rats and prevent heart injury.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"255 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74888254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Asadolahizoj, D. Saadati, M. Rasekh, A. Jafari, Amirmasood Jafari Nozad, F. Faghihi, Z. Telmadarraiy, A. Hosseini-Chegeni
Background and Objectives Coxiella burnetii (causative agent of Q fever) is an important zoonotic disease with a universal occurrence. Ticks are natural and potential reservoirs of this bacterium and play an effective role in the transmission of Q fever. This study aimed to investigate the prevalence of Coxiella burnetii in hard ticks isolated from livestock in Sistan. Subjects and Methods This cross-sectional study was conducted in five counties of the Sistan region. The genus and species of hard ticks were identified after collection from some domestic animals. The nested- PCR technique was used to identify the bacterial genome. Results Of all examined ticks, two genera, including 354 Hyalomma (59.399%) and 242 Rhipicephalus (40.6%) were identified. The hard ticks are in three types of species as follows: Rhipicephalus sanguineus (40.1%), Rhipicephalus nymph (0.5%), Hyalomma anatolicum (47.5%), Hyalomma sp. (1.5%), Hyalomma nymph (10.4%), and Rhipicephalus (Boophilus) annulatus (0.16%). No infected specimen with Coxiella burnetii was observed in the Sistan region. Conclusion According to the results of previous studies in Sistan and Baluchestan province and neighboring provinces that reported a high prevalence of Coxiella burnetii in collected ticks, it seems that more extensive research, with a larger sample size and host range, is necessary to clarify the situation of this pathogen.
{"title":"Molecular Investigation of Coxiella Burnetii in Hard Ticks Collected From Some Livestock in the Sistan Region","authors":"Sahar Asadolahizoj, D. Saadati, M. Rasekh, A. Jafari, Amirmasood Jafari Nozad, F. Faghihi, Z. Telmadarraiy, A. Hosseini-Chegeni","doi":"10.32598/jsmj.21.3.2460","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2460","url":null,"abstract":"Background and Objectives Coxiella burnetii (causative agent of Q fever) is an important zoonotic disease with a universal occurrence. Ticks are natural and potential reservoirs of this bacterium and play an effective role in the transmission of Q fever. This study aimed to investigate the prevalence of Coxiella burnetii in hard ticks isolated from livestock in Sistan. Subjects and Methods This cross-sectional study was conducted in five counties of the Sistan region. The genus and species of hard ticks were identified after collection from some domestic animals. The nested- PCR technique was used to identify the bacterial genome. Results Of all examined ticks, two genera, including 354 Hyalomma (59.399%) and 242 Rhipicephalus (40.6%) were identified. The hard ticks are in three types of species as follows: Rhipicephalus sanguineus (40.1%), Rhipicephalus nymph (0.5%), Hyalomma anatolicum (47.5%), Hyalomma sp. (1.5%), Hyalomma nymph (10.4%), and Rhipicephalus (Boophilus) annulatus (0.16%). No infected specimen with Coxiella burnetii was observed in the Sistan region. Conclusion According to the results of previous studies in Sistan and Baluchestan province and neighboring provinces that reported a high prevalence of Coxiella burnetii in collected ticks, it seems that more extensive research, with a larger sample size and host range, is necessary to clarify the situation of this pathogen.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88507076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehrara Souri, Aliasghar Rvasi, A. Birar, Faezeh Heydari, Haniyeh Yousefzadeh, Abas Hosseini
Background and Objectives Regular aerobic exercise improves learning, memory, and cognitive and Synaptic Plasticity in Alzheimer’s disease (AD) patients. The aim of this study was to evaluate the levels of calcineurin and Ca2+/calmodulin-dependent protein kinase II mRNA after four weeks of aerobic training exercises and before AD induction in the hippocampus of male Wistar rats. Subjects and Methods Thirty 8-week-old rats with an average weight of 195±20 g were initially randomly divided into two groups of aerobic exercise or rest for four weeks. Then, each group was divided into three groups of AD, sham, and injection. Then, 48 hours after the last training session, Aβ1-42, or DMSO was injected into the hippocampus. Finally, after the isolation of the hippocampus, CaN mRNA and CaMKII mRNA levels were measured. Results The results of this study showed that there was a significant difference between the groups in mRNA CaN and CaMKII mRNA levels (P<0.05). The results showed that aerobic exercise and AD pre-induction had a significant effect on increasing calcineurin and Ca2+/calmodulin-dependent protein kinase II levels. Conclusion Overall, the findings of the present study showed that four weeks of aerobic training improves the molecular signaling of neuroplasticity in AD rats.
{"title":"The Effect of Aerobic Training before Alzheimer’s Induction on the Expression of Calcineurin and Ca2+/Calmodulin-dependent Protein Kinase II Gene in the Hippocampus of Rats with Alzheimer’s Disease","authors":"Mehrara Souri, Aliasghar Rvasi, A. Birar, Faezeh Heydari, Haniyeh Yousefzadeh, Abas Hosseini","doi":"10.32598/jsmj.21.3.2548","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2548","url":null,"abstract":"Background and Objectives Regular aerobic exercise improves learning, memory, and cognitive and Synaptic Plasticity in Alzheimer’s disease (AD) patients. The aim of this study was to evaluate the levels of calcineurin and Ca2+/calmodulin-dependent protein kinase II mRNA after four weeks of aerobic training exercises and before AD induction in the hippocampus of male Wistar rats. Subjects and Methods Thirty 8-week-old rats with an average weight of 195±20 g were initially randomly divided into two groups of aerobic exercise or rest for four weeks. Then, each group was divided into three groups of AD, sham, and injection. Then, 48 hours after the last training session, Aβ1-42, or DMSO was injected into the hippocampus. Finally, after the isolation of the hippocampus, CaN mRNA and CaMKII mRNA levels were measured. Results The results of this study showed that there was a significant difference between the groups in mRNA CaN and CaMKII mRNA levels (P<0.05). The results showed that aerobic exercise and AD pre-induction had a significant effect on increasing calcineurin and Ca2+/calmodulin-dependent protein kinase II levels. Conclusion Overall, the findings of the present study showed that four weeks of aerobic training improves the molecular signaling of neuroplasticity in AD rats.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"281 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76804591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fateme Najarzadegan, Somayyeh Hajiahmadi, A. Adibi
Background and Objectives This study aims to assess the frequency of positive lumbosacral magnetic resonance imaging (MRI) results in patients with non-traumatic low back pain (LBP) based on the specialty of the referring physician. Subjects and Methods In this retrospective study, 335 patients with non-traumatic LBP aged >18 years participated. Their demographic information and MRI findings and the specialty of the referring physician were extracted and recorded from the imaging information system of a hospital. Frequency of positive lumbosacral MRI results based on the specialty of the referring physician were compared. To avoid bias, the MRIs with a same imaging protocol were selected, and reporting was done by a same radiologist. Results Of 335 patients, 145(43.3%) were male and 190(57.6%) were female. Among the referring physicians, 139(41.5%) were neurosurgeon, 114(34%) were orthopedists, 61(18.2%) were neurologists, and 21(6.3%) were physical medicine specialist. There was no significant difference in positive MRI results between different specialties of the referring physicians (P>0.05). Conclusion There is no difference in the frequency of positive lumbosacral MRI results in patients with non-traumatic LBP treated by orthopedics, neurologists, neurosurgeons, and physical medicine specialists.
{"title":"Frequency of Positive Lumbosacral MRI Results in Patients Ton-traumatic low Back Pain Based on the Specialty of the Referring Physician","authors":"Fateme Najarzadegan, Somayyeh Hajiahmadi, A. Adibi","doi":"10.32598/jsmj.21.2.2252","DOIUrl":"https://doi.org/10.32598/jsmj.21.2.2252","url":null,"abstract":"Background and Objectives This study aims to assess the frequency of positive lumbosacral magnetic resonance imaging (MRI) results in patients with non-traumatic low back pain (LBP) based on the specialty of the referring physician. Subjects and Methods In this retrospective study, 335 patients with non-traumatic LBP aged >18 years participated. Their demographic information and MRI findings and the specialty of the referring physician were extracted and recorded from the imaging information system of a hospital. Frequency of positive lumbosacral MRI results based on the specialty of the referring physician were compared. To avoid bias, the MRIs with a same imaging protocol were selected, and reporting was done by a same radiologist. Results Of 335 patients, 145(43.3%) were male and 190(57.6%) were female. Among the referring physicians, 139(41.5%) were neurosurgeon, 114(34%) were orthopedists, 61(18.2%) were neurologists, and 21(6.3%) were physical medicine specialist. There was no significant difference in positive MRI results between different specialties of the referring physicians (P>0.05). Conclusion There is no difference in the frequency of positive lumbosacral MRI results in patients with non-traumatic LBP treated by orthopedics, neurologists, neurosurgeons, and physical medicine specialists.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"176 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77345606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives Despite several studies and abundant efforts to control microbial agents, humans have not yet been able to eliminate these agents. Recent studies have shown that gold(I) compounds are promising candidates for making antimicrobial drugs. The interest in gold-based drugs is increasing day by day. Inhibition of the thioredoxin reductase (TrxR) enzyme is the most important biological target for antimicrobial gold(I) compounds. Subjects and Methods In this study, the antimicrobial properties of five diphenyl pyridine phosphine gold(I)-thiolate compounds against gram-positive bacteria (P. aeruginosa, E. coli), gram-negative bacteria (S. aureus, B. subtilis), a fungus (C. albicans), and a yeast (S. cerevisiae) were evaluated. The molecular docking studies were carried out using AutoDock 4.2 to find the best compound in the active site of the TrxR enzyme (PDB ID: 4CBQ). Results The gold(I) compounds had a minimum inhibitory concentration (MIC) value ranged from 3 to 100 μg/mL. The most active compound was Au3 which had a MIC of 3.89, 3.15, 4.36, 5.44, 6.13, and 8.37 μg/mL against P. aeruginosa, E. coli, S. aureus, B. subtilis, C. albicans and S. cerevisiae, respectively. Conclusion The gold(I) compounds act better on gram-negative bacteria and yeast strains compared to auranofin as antirheumatic drug. These compounds, especially the Au3, are potentially valuable for the control of antimicrobial agents.
{"title":"Antimicrobial Activity of Diphenyl Pyridine Phosphine Gold(I)-thiolate Compounds and their Molecular Docking With Thioredoxin Reductase Enzyme","authors":"Masood Fereidoonnezhad, Salar Nosrati","doi":"10.32598/jsmj.21.2.2231","DOIUrl":"https://doi.org/10.32598/jsmj.21.2.2231","url":null,"abstract":"Background and Objectives Despite several studies and abundant efforts to control microbial agents, humans have not yet been able to eliminate these agents. Recent studies have shown that gold(I) compounds are promising candidates for making antimicrobial drugs. The interest in gold-based drugs is increasing day by day. Inhibition of the thioredoxin reductase (TrxR) enzyme is the most important biological target for antimicrobial gold(I) compounds. Subjects and Methods In this study, the antimicrobial properties of five diphenyl pyridine phosphine gold(I)-thiolate compounds against gram-positive bacteria (P. aeruginosa, E. coli), gram-negative bacteria (S. aureus, B. subtilis), a fungus (C. albicans), and a yeast (S. cerevisiae) were evaluated. The molecular docking studies were carried out using AutoDock 4.2 to find the best compound in the active site of the TrxR enzyme (PDB ID: 4CBQ). Results The gold(I) compounds had a minimum inhibitory concentration (MIC) value ranged from 3 to 100 μg/mL. The most active compound was Au3 which had a MIC of 3.89, 3.15, 4.36, 5.44, 6.13, and 8.37 μg/mL against P. aeruginosa, E. coli, S. aureus, B. subtilis, C. albicans and S. cerevisiae, respectively. Conclusion The gold(I) compounds act better on gram-negative bacteria and yeast strains compared to auranofin as antirheumatic drug. These compounds, especially the Au3, are potentially valuable for the control of antimicrobial agents.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87308256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tohid Piri Gharaghie, Sheida Beiranvand, Amir Ghadiri, Sameh Hajimohammadi
Coronavirus disease 2019 (COVID-19) is an acute respiratory infection. Its virus called SARS-COV-2 which is an RNA virus with high homology to the bat coronavirus. In this review study, first the molecular and cellular characteristics and the proliferation and replication of SARS-COV-2 are investigated. Then, by reviewing bioinformatics studies regarding protected domain analysis, homology modeling, and molecular docking, the biological role of some specific SARS-COV-2 proteins are examined. The results showed that the open reading frame 8 (ORF8) and surface glycoprotein could bind to porphyrin. At the same time, ORF1ab, ORF10, and ORF3a can attack the heme part of hemoglobin to dissociate iron and form porphyrin. This attack reduces hemoglobin ability to carry oxygen and carbon dioxide. As a result, lung cells become severely inflamed due to their inability to exchange carbon dioxide and oxygen, which leads to large ground-glass opacities on CT scan images. Based on the bioinformatics results, chloroquine can prevent ORF1ab, ORF3a, and ORF10 from attacking hemoglobin to form porphyrin and avoid the binding of ORF8 and surface glycoprotein to porphyrin, which effectively relieves the symptoms of acute respiratory syndrome. In the current pandemic, bioinformatics studies are of great importance for preventing the spread of COVID-19, developing drugs and vaccines, and clinical practice.
{"title":"A Review of Bioinformatics Studies on the Function of Structural and Nonstructural Proteins and the Level of Glycoprotein Inhibiting Heme Metabolism by SARS-CoV-2 Virus","authors":"Tohid Piri Gharaghie, Sheida Beiranvand, Amir Ghadiri, Sameh Hajimohammadi","doi":"10.32598/JSMJ.21.2.2164","DOIUrl":"https://doi.org/10.32598/JSMJ.21.2.2164","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is an acute respiratory infection. Its virus called SARS-COV-2 which is an RNA virus with high homology to the bat coronavirus. In this review study, first the molecular and cellular characteristics and the proliferation and replication of SARS-COV-2 are investigated. Then, by reviewing bioinformatics studies regarding protected domain analysis, homology modeling, and molecular docking, the biological role of some specific SARS-COV-2 proteins are examined. The results showed that the open reading frame 8 (ORF8) and surface glycoprotein could bind to porphyrin. At the same time, ORF1ab, ORF10, and ORF3a can attack the heme part of hemoglobin to dissociate iron and form porphyrin. This attack reduces hemoglobin ability to carry oxygen and carbon dioxide. As a result, lung cells become severely inflamed due to their inability to exchange carbon dioxide and oxygen, which leads to large ground-glass opacities on CT scan images. Based on the bioinformatics results, chloroquine can prevent ORF1ab, ORF3a, and ORF10 from attacking hemoglobin to form porphyrin and avoid the binding of ORF8 and surface glycoprotein to porphyrin, which effectively relieves the symptoms of acute respiratory syndrome. In the current pandemic, bioinformatics studies are of great importance for preventing the spread of COVID-19, developing drugs and vaccines, and clinical practice.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80010854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ramezani, M. D. Shasaltaneh, Muhammad Mehdi Amiri Khorie
Background and Objectives Herbal plants are an important source of novel chemical drugs with therapeutic effects. The present study aims to find the chemical compounds of the essential oil of lavender (Lavandula angustifolia Miller) and assess their antagonistic effects on N-methyl-D-aspartate receptor (NMDAR) subunit NR2B in the brain. Subjects and Methods The essential oil was first isolated by distillation method from flowering inflorescences of lavender. Then, their chemical compounds were identifies by gas chromatography/mass spectrometry (GC-MS). Molecular docking study and the evaluation of the molecular structures were carried out on 20 compounds. Pyrx software, version 4.0 in Autodock Vina was used to perform the molecular docking of 20 ligands with NMDAR. The molecular structures of compounds were evaluated in SwissADME website. Results In GC-MS, 41 active compounds were detected comprising 95.5% of the total essential oil of lavender plant. The highest amount was related to trans-carveol, followed by isopulegol, 1,3,8, -p-menthatriene, and isoborneol. In docking studies, results showed that the best ligands for binding to NMDAR included trans-carveol, isopulegol, and 1,3,8, -p-menthatriene which demonstrated the higher affinity to active site of the NMDAR. Ifenprodil, as an antagonist, shared common binding sites with camphor, thymol, alpha-phellandrene, limonene, gamma-3-carene, beta-thujone, trans-Carveol, beta-caryophyllene. Camphor, thymol, beta-thujone and trans-carveol had the highest gastrointestinal absorption, and transcarveol had the lowest binding energy to NMDAR. Conclusion Camphor, thymol, beta-thujone, and trans-carveol are potential compounds of lavender essential oil to inhibit NMDAR and improve learning and memory in neurodegenerative diseases.
背景与目的中草药是具有治疗作用的新型化学药物的重要来源。本研究旨在发现薰衣草精油的化学成分，并评估其对脑内n -甲基- d -天冬氨酸受体(NMDAR)亚基NR2B的拮抗作用。研究对象与方法首次采用蒸馏法从薰衣草开花花序中分离得到精油。然后，采用气相色谱/质谱联用技术(GC-MS)对其化学成分进行鉴定。对20个化合物进行了分子对接研究和分子结构评价。使用Autodock Vina中的Pyrx 4.0版软件对20个配体与NMDAR进行分子对接。化合物的分子结构在SwissADME网站上进行了评价。结果GC-MS共检出41种有效成分，占薰衣草精油总含量的95.5%。反式卡维罗含量最高，其次是异戊二醇、1,3,8、-对薄荷烯和异龙脑。对接研究结果表明，与NMDAR结合的最佳配体包括反式卡维罗、异戊二醇和1,3,8，-对孟三烯，这些配体对NMDAR的活性位点具有较高的亲和力。作为拮抗剂，伊芬普罗地尔与樟脑、百里酚、-茶树烯、柠檬烯、-3-蒈烯、-图琼、反式卡维罗、-石竹烯具有共同的结合位点。樟脑、百里酚、β -图琼和反式卡维罗对NMDAR的胃肠道吸收最高，而反式卡维罗对NMDAR的结合能最低。结论樟脑、百里酚、β -图琼和反式卡维罗是薰衣草精油抑制NMDAR和改善神经退行性疾病学习记忆的潜在化合物。
{"title":"Lavender Essential oil Compounds as Antagonists of NMDA Receptor Subunit NR2B: A Molecular Modeling and Experimental Study","authors":"S. Ramezani, M. D. Shasaltaneh, Muhammad Mehdi Amiri Khorie","doi":"10.32598/jsmj.21.2.2257","DOIUrl":"https://doi.org/10.32598/jsmj.21.2.2257","url":null,"abstract":"Background and Objectives Herbal plants are an important source of novel chemical drugs with therapeutic effects. The present study aims to find the chemical compounds of the essential oil of lavender (Lavandula angustifolia Miller) and assess their antagonistic effects on N-methyl-D-aspartate receptor (NMDAR) subunit NR2B in the brain. Subjects and Methods The essential oil was first isolated by distillation method from flowering inflorescences of lavender. Then, their chemical compounds were identifies by gas chromatography/mass spectrometry (GC-MS). Molecular docking study and the evaluation of the molecular structures were carried out on 20 compounds. Pyrx software, version 4.0 in Autodock Vina was used to perform the molecular docking of 20 ligands with NMDAR. The molecular structures of compounds were evaluated in SwissADME website. Results In GC-MS, 41 active compounds were detected comprising 95.5% of the total essential oil of lavender plant. The highest amount was related to trans-carveol, followed by isopulegol, 1,3,8, -p-menthatriene, and isoborneol. In docking studies, results showed that the best ligands for binding to NMDAR included trans-carveol, isopulegol, and 1,3,8, -p-menthatriene which demonstrated the higher affinity to active site of the NMDAR. Ifenprodil, as an antagonist, shared common binding sites with camphor, thymol, alpha-phellandrene, limonene, gamma-3-carene, beta-thujone, trans-Carveol, beta-caryophyllene. Camphor, thymol, beta-thujone and trans-carveol had the highest gastrointestinal absorption, and transcarveol had the lowest binding energy to NMDAR. Conclusion Camphor, thymol, beta-thujone, and trans-carveol are potential compounds of lavender essential oil to inhibit NMDAR and improve learning and memory in neurodegenerative diseases.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90115438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahdieh-Sadat Moosavi, F. Agha-Hosseini, Hoda Barati, Yalda Elham
Background and Objectives Oral lichen planus (OLP) is an chronic inflammatory mucocutaneous disease, which mostly affect the oral mucosa. This study aims to review the studies related to the presence of xerostomia (dry mouth) in patients with OLP and its possible mechanisms. Subjects and Methods In this review study, a search was conducted in Medline, Scopus, Embase and Web of Science databases on related studies published from 1965 to 2021 using the keywords oral lichen planus, xerostomia, hyposalivation, salivary gland hypofunction, and oral dryness. Clinical studies on the association between OLP and xerostomia, and those with well-defined design and methodology were included in the review. Results About 8 articles were finally selected based on the entry criteria. These articles were about the histopathological examination of salivary glands, evaluation of salivary compositions, saliva flow rate assessment, and feeling of dry mouth using a questionnaire. Conclusion The relationship between OLP and xerostomia has been shown in many studies. Various mechanisms have been proposed in this regard. The mentioned mechanisms are the inflammatory and autoimmune disorders of the sensory nervous system, changes in saliva composition, and changes in the saliva flow rate.
背景与目的口腔扁平苔藓(OLP)是一种慢性炎症性粘膜皮肤病，主要累及口腔黏膜。本研究旨在综述OLP患者口干症的相关研究及其可能的机制。本综述性研究在Medline、Scopus、Embase和Web of Science数据库中检索1965 - 2021年间发表的相关研究，检索关键词为口腔扁平苔藓、口干症、唾液分泌不足、唾唾腺功能减退和口腔干燥。关于OLP与口干症之间关系的临床研究，以及那些具有明确设计和方法的研究均被纳入本综述。结果根据入选标准最终筛选出8篇文章。这些文章是关于唾液腺的组织病理学检查，唾液成分的评估，唾液流速评估和口干的感觉使用问卷。结论OLP与口干症的关系已被许多研究证实。在这方面提出了各种机制。上述机制包括感觉神经系统的炎症和自身免疫性疾病、唾液成分的改变和唾液流速的改变。
{"title":"Xerostomia in Patients With Oral Lichen Planus: A Review","authors":"Mahdieh-Sadat Moosavi, F. Agha-Hosseini, Hoda Barati, Yalda Elham","doi":"10.32598/jsmj.21.2.2362","DOIUrl":"https://doi.org/10.32598/jsmj.21.2.2362","url":null,"abstract":"Background and Objectives Oral lichen planus (OLP) is an chronic inflammatory mucocutaneous disease, which mostly affect the oral mucosa. This study aims to review the studies related to the presence of xerostomia (dry mouth) in patients with OLP and its possible mechanisms. Subjects and Methods In this review study, a search was conducted in Medline, Scopus, Embase and Web of Science databases on related studies published from 1965 to 2021 using the keywords oral lichen planus, xerostomia, hyposalivation, salivary gland hypofunction, and oral dryness. Clinical studies on the association between OLP and xerostomia, and those with well-defined design and methodology were included in the review. Results About 8 articles were finally selected based on the entry criteria. These articles were about the histopathological examination of salivary glands, evaluation of salivary compositions, saliva flow rate assessment, and feeling of dry mouth using a questionnaire. Conclusion The relationship between OLP and xerostomia has been shown in many studies. Various mechanisms have been proposed in this regard. The mentioned mechanisms are the inflammatory and autoimmune disorders of the sensory nervous system, changes in saliva composition, and changes in the saliva flow rate.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90312963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives Unplanned pregnancy in the first year after delivery in high-risk and adolescent mothers can have numerous complications. This study aims to investigate the effective strategies for the use of contraceptive methods in the postpartum period by adolescent mothers in Iran. Subjects and Methods This qualitative study, using the nominal group technique (NGT), was conducted in 2019 during a journal club with the presence of professors and students in midwifery and reproductive health. The NGT included five steps: Recording of ideas during 5 minutes of silence, clarifying ideas, prioritizing important ideas, voting, and selecting the first five priorities. Results Five priorities were education, counseling, providing the contraceptive methods, modification of population policies, and correct identification of the vulnerable groups. Accordingly, strategies were categorized as (a) evidence-based education and counseling on appropriate use of contraceptive methods during pregnancy, after delivery, and during postnatal visits, (b) providing contraceptive methods to the high-risk group of women for free in health centers, and (c) modification of population policies. Conclusion There are appropriate strategies for the contraceptive use such as education, counseling, providing the contraceptive methods, and modification of population policies that can temporarily prevent pregnancy in high-risk adolescent women in Iran.
{"title":"Effective Strategies for the Use o Contraceptive Methods in the Postpartum Period by Adolescent Mothers in Iran Using Nominal Group Technique","authors":"Nasim Bozorgi, Z. Shahhosseini, S. Khani","doi":"10.32598/jsmj.21.2.2348","DOIUrl":"https://doi.org/10.32598/jsmj.21.2.2348","url":null,"abstract":"Background and Objectives Unplanned pregnancy in the first year after delivery in high-risk and adolescent mothers can have numerous complications. This study aims to investigate the effective strategies for the use of contraceptive methods in the postpartum period by adolescent mothers in Iran. Subjects and Methods This qualitative study, using the nominal group technique (NGT), was conducted in 2019 during a journal club with the presence of professors and students in midwifery and reproductive health. The NGT included five steps: Recording of ideas during 5 minutes of silence, clarifying ideas, prioritizing important ideas, voting, and selecting the first five priorities. Results Five priorities were education, counseling, providing the contraceptive methods, modification of population policies, and correct identification of the vulnerable groups. Accordingly, strategies were categorized as (a) evidence-based education and counseling on appropriate use of contraceptive methods during pregnancy, after delivery, and during postnatal visits, (b) providing contraceptive methods to the high-risk group of women for free in health centers, and (c) modification of population policies. Conclusion There are appropriate strategies for the contraceptive use such as education, counseling, providing the contraceptive methods, and modification of population policies that can temporarily prevent pregnancy in high-risk adolescent women in Iran.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80715008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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