Mostafa Khodadoost, S. Shakerian, S. Arjmand, M. Nikbakht
Background and Objective: The aim this study was to investigate the effect of sedentary lifestyle on Telomere system of mice skeletal muscle. Methods: The subjects were C57BL/6 mice (n=24) that were randomly divided into four groups: Base control (n=6), control (n=6), LIIT (n=6), and HIIT (n=6) groups. The exercise includes 5 days a week for 8 weeks and then kept inactive for 4 weeks. The factors were measured after DNA and RNA extraction using Real time-PCR method. The data were evaluated using two-way ANOVA test. Results: The results of this study showed that there wasn’t a significant difference between the expression of TRF1 gene in ST and FT muscles (P=0.825), sedentary lifestyle type (P=0.062) and the interaction between muscle type and sedentary lifestyle type (P=0.408). There was no significant difference between the expression of TRF2 gene in ST and FT muscles (P=0.073), sedentary lifestyle type (P=0.309) and the interaction between muscle type and sedentary lifestyle type (P=0.093). In general, There was no significant difference between the telomere length in ST and FT muscles (P=0.763), sedentary lifestyle type (P=0.053) and the interaction between muscle type and sedentary lifestyle type (P=0.651). Conclusion: Applying sedentary lifestyle types, including inactivity after High and low-intensity exercise, affects the telomere system in skeletal muscle in both muscles the same. It seems that the effect of inactivity in people with an experience of exercise with different intensities does not have a different effect on the type of skeletal muscle tissue.
{"title":"Effect of Detraining Type on Telomere Length and TRF1& TRF2 Gene Expression of Skeletal Muscle in C57BL/6 Male Mice","authors":"Mostafa Khodadoost, S. Shakerian, S. Arjmand, M. Nikbakht","doi":"10.32598/jsmj.21.1.2719","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2719","url":null,"abstract":"Background and Objective: The aim this study was to investigate the effect of sedentary lifestyle on Telomere system of mice skeletal muscle. Methods: The subjects were C57BL/6 mice (n=24) that were randomly divided into four groups: Base control (n=6), control (n=6), LIIT (n=6), and HIIT (n=6) groups. The exercise includes 5 days a week for 8 weeks and then kept inactive for 4 weeks. The factors were measured after DNA and RNA extraction using Real time-PCR method. The data were evaluated using two-way ANOVA test. Results: The results of this study showed that there wasn’t a significant difference between the expression of TRF1 gene in ST and FT muscles (P=0.825), sedentary lifestyle type (P=0.062) and the interaction between muscle type and sedentary lifestyle type (P=0.408). There was no significant difference between the expression of TRF2 gene in ST and FT muscles (P=0.073), sedentary lifestyle type (P=0.309) and the interaction between muscle type and sedentary lifestyle type (P=0.093). In general, There was no significant difference between the telomere length in ST and FT muscles (P=0.763), sedentary lifestyle type (P=0.053) and the interaction between muscle type and sedentary lifestyle type (P=0.651). Conclusion: Applying sedentary lifestyle types, including inactivity after High and low-intensity exercise, affects the telomere system in skeletal muscle in both muscles the same. It seems that the effect of inactivity in people with an experience of exercise with different intensities does not have a different effect on the type of skeletal muscle tissue.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86941400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reza Zadeh-Dabbagh, M. Hashemi, Marzieh Massah, E. Taherian, Naji Sayyahi, Farkhondeh Haghparasti, M. Marhamati, L. Alavi, Nikoo Bahrami, Maliheh Karami, S. M. A. Noori
Background and Objectives Falafel is one of the most popular artisanal foods in Iran, especially in Khouzestan province. However, no comprehensive study has been performed to evaluate its microbiological and chemical properties. This study aims to evaluate microbiological and chemical properties of falafel samples collected from street food market in Ahvaz, Iran. Subjects and Methods Microbiological tests including total viable count (TVC), psychrophilic count, Escherichia coli test, staphylococcus aureus test, coliform count, bacillus cereus test, Salmonella test, and mold count were performed to evaluate microbiological properties of falafel samples (cooked and uncooked). The chemical properties were assessed by performing protein test, ash, carbohydrate, lipid, salt, peroxide, and acidity tests. All tests were done according to the methods described by the Institute of Standards & Industrial Research of Iran (ISIRI). Results Microbiological tests revealed that TVC (108 cfu/g), coliform count (3.7×103 cfu/g) and mold count (1.3×103 cfu/g) were significantly higher than the amounts set by the ISIRI (P<0.05), indicating high contamination of uncooked falafel samples. The major problems observed by chemical tests was the high content of lipid (20.11%) and peroxide value (47.85 meq/kg) which were significantly higher than the values set by the ISIRI (P<0.05). Conclusion Microbiological and chemical properties of falafel are poor, indicating the poor hygienic conditions of its preparation in street food market. We recommend more attention to and supervision on the preparation of artisanal foods such as falafel in Iran.
{"title":"Microbiological and Chemical Properties of Falafel Samples Collected From Street Food Market in Ahvaz, Iran","authors":"Reza Zadeh-Dabbagh, M. Hashemi, Marzieh Massah, E. Taherian, Naji Sayyahi, Farkhondeh Haghparasti, M. Marhamati, L. Alavi, Nikoo Bahrami, Maliheh Karami, S. M. A. Noori","doi":"10.32598/jsmj.21.1.2708","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2708","url":null,"abstract":"Background and Objectives Falafel is one of the most popular artisanal foods in Iran, especially in Khouzestan province. However, no comprehensive study has been performed to evaluate its microbiological and chemical properties. This study aims to evaluate microbiological and chemical properties of falafel samples collected from street food market in Ahvaz, Iran. Subjects and Methods Microbiological tests including total viable count (TVC), psychrophilic count, Escherichia coli test, staphylococcus aureus test, coliform count, bacillus cereus test, Salmonella test, and mold count were performed to evaluate microbiological properties of falafel samples (cooked and uncooked). The chemical properties were assessed by performing protein test, ash, carbohydrate, lipid, salt, peroxide, and acidity tests. All tests were done according to the methods described by the Institute of Standards & Industrial Research of Iran (ISIRI). Results Microbiological tests revealed that TVC (108 cfu/g), coliform count (3.7×103 cfu/g) and mold count (1.3×103 cfu/g) were significantly higher than the amounts set by the ISIRI (P<0.05), indicating high contamination of uncooked falafel samples. The major problems observed by chemical tests was the high content of lipid (20.11%) and peroxide value (47.85 meq/kg) which were significantly higher than the values set by the ISIRI (P<0.05). Conclusion Microbiological and chemical properties of falafel are poor, indicating the poor hygienic conditions of its preparation in street food market. We recommend more attention to and supervision on the preparation of artisanal foods such as falafel in Iran.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83687813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maliha Goli, Saeede Samare Mousavi, R. Rahbarian, Majid Rajabiyan
Background and Objectives Herbal medicines have fewer side effects than chemical drugs. In this regard, researchers are looking to find herbal ingredients to heal diabetic wounds. Saffron is a powerful antioxidant that can be effective in treating diabetic wounds. This study aims to evaluate the effect of saffron’s main ingredients (crocin and safranal) on skin wound healing in streptozotocin-induced diabetic rats. Subjects and Methods In this experimental study, 30 rats were divided into six groups. One control group, one diabetic group, two diabetic groups treated with crocin (300 and 600 mg/kg body weight), and two diabetic groups treated with safranal (300 and 600 mg/kg body weight). The diabetes was induced by intraperitoneal injection of streptozotocin (55 mg/kg body weight). Sampling was performed for histological studies to measure the number of neutrophils, macrophages, blood vessels, and epithelium thickness on days 3, 7, 15 and 20 after wound creation. Results The collected data were analyzed by one-way analysis of variance and the least significant difference test, considering the significance level of P<0.05. Conclusion Crocin and safranal components of saffron can accelerate the wound healing process in diabetic rats by affecting the number of neutrophils, macrophages, blood vessels, and epithelial thickness.
{"title":"The Effect Of Crocin and Safranal Components of Saffron on Skin Wound Healing in Streptozotocin-Induced Diabetic Rat","authors":"Maliha Goli, Saeede Samare Mousavi, R. Rahbarian, Majid Rajabiyan","doi":"10.32598/jsmj.21.1.2358","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2358","url":null,"abstract":"Background and Objectives Herbal medicines have fewer side effects than chemical drugs. In this regard, researchers are looking to find herbal ingredients to heal diabetic wounds. Saffron is a powerful antioxidant that can be effective in treating diabetic wounds. This study aims to evaluate the effect of saffron’s main ingredients (crocin and safranal) on skin wound healing in streptozotocin-induced diabetic rats. Subjects and Methods In this experimental study, 30 rats were divided into six groups. One control group, one diabetic group, two diabetic groups treated with crocin (300 and 600 mg/kg body weight), and two diabetic groups treated with safranal (300 and 600 mg/kg body weight). The diabetes was induced by intraperitoneal injection of streptozotocin (55 mg/kg body weight). Sampling was performed for histological studies to measure the number of neutrophils, macrophages, blood vessels, and epithelium thickness on days 3, 7, 15 and 20 after wound creation. Results The collected data were analyzed by one-way analysis of variance and the least significant difference test, considering the significance level of P<0.05. Conclusion Crocin and safranal components of saffron can accelerate the wound healing process in diabetic rats by affecting the number of neutrophils, macrophages, blood vessels, and epithelial thickness.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78570453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mohammadzadeh, Ali Dehghan Ahmadabad, Z. Sharafi, Farzad Hamzehpour
Background and Objectives Due to the improvement of living conditions in recent decades, there is an important issue called quality of life (QoL). One of the important factors that affect the QoL is the ability to communicate with others. Everyday communication is usually interfered by noise. Consonants play an important role in understanding the meaning of words. Since stop consonants are dependent on the following vowels, they are more vulnerable to the masking effects of noise. The present study aims to evaluate the effect of age, signal-to-noise ratio (SNR), and concurrent vowels on the recognition of stop consonants in Persian. Subjects and Methods The present cross-sectional study was conducted on 60 adults with normal hearing in two age groups of 30-39 and 40-49 years. After the auditory and speech assessments, the recognition of stop consonants in the form of consonant-vowel-consonant syllables and in the presence of babble noise at three SNRs was compared between two age groups. Results The difference in the recognition score of stop consonants was significant between two age groups at the SNRs of 0, -5, and -10. There was also a significant difference between the two age groups regarding the recognition of stop consonants in the presence of some vowels at three SNRs. Conclusion With increasing age, the recognition ability of stop consonants in the presence of babble noises decreases. Increasing noise also reduces the recognition of stop consonants, especially those with some vowels.
{"title":"Comparing the Recognition of Stop Consonants in Persian Between Adults Aged 30-39 and 40-49 Years","authors":"A. Mohammadzadeh, Ali Dehghan Ahmadabad, Z. Sharafi, Farzad Hamzehpour","doi":"10.32598/jsmj.21.1.2354","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2354","url":null,"abstract":"Background and Objectives Due to the improvement of living conditions in recent decades, there is an important issue called quality of life (QoL). One of the important factors that affect the QoL is the ability to communicate with others. Everyday communication is usually interfered by noise. Consonants play an important role in understanding the meaning of words. Since stop consonants are dependent on the following vowels, they are more vulnerable to the masking effects of noise. The present study aims to evaluate the effect of age, signal-to-noise ratio (SNR), and concurrent vowels on the recognition of stop consonants in Persian. Subjects and Methods The present cross-sectional study was conducted on 60 adults with normal hearing in two age groups of 30-39 and 40-49 years. After the auditory and speech assessments, the recognition of stop consonants in the form of consonant-vowel-consonant syllables and in the presence of babble noise at three SNRs was compared between two age groups. Results The difference in the recognition score of stop consonants was significant between two age groups at the SNRs of 0, -5, and -10. There was also a significant difference between the two age groups regarding the recognition of stop consonants in the presence of some vowels at three SNRs. Conclusion With increasing age, the recognition ability of stop consonants in the presence of babble noises decreases. Increasing noise also reduces the recognition of stop consonants, especially those with some vowels.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74118254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rahmani Ghobadi, Seyyed Ali Hoseini, Ghobad Hasanpour
Background and Objectives The aim of this study was to Acute changes in aldolase activity and some hematologic parameters compared to different recoveries. Subjects and Methods The research is of applied type and quasi-experimental research method which was conducted in field-laboratory form with pre-test-post-test design with control group on female semiprofessional athletes in athletics (runners) in Tehran. Sampling was done by simple random sampling, so that after informing and inviting interested people and passing the preliminary stages, 30 runners were selected as the research sample and randomly in 3 groups of 10 people (active recycling group (running), inactivated recycling group (sports massage) and inactive sitting). The main activity included a sports competition. Blood samples were taken from the samples in 3 stages (pre-test (fasting), post-race and post-recovery). In this study, one-way analysis of variance and SPSS statistical software v. 22 were used to examine the data at a significance level of P<0.05. Results The results of this study showed that there is no significant difference between the three types of recycling methods in changing the amount of aldolase and erythrocyte factors (P>0.05), but recycling by massage has an effect on reducing aldolase levels after strenuous exercise. There is a significant difference between the three types of recycling methods (passive, jogging, massage) in reducing the number of white blood cells and hemoglobin in favor of recovery by the massage group. Conclusion According to the results, it can be said that among the recovery methods, the use of massage was more effective in reducing the aldolase activity of female athletes after the run competition.
背景和目的本研究的目的是比较不同恢复期间醛缩酶活性和一些血液学参数的急性变化。本研究采用应用性、准实验性的研究方法，采用前测后测设计，以德黑兰地区半职业女田径运动员(赛跑运动员)为研究对象，与对照组进行现场-实验室研究。抽样采用简单随机抽样的方式，在通知并邀请感兴趣的人并通过前期调查后，选择30名跑步者作为研究样本，随机分为3组，每组10人(积极回收组(跑步)、不积极回收组(运动按摩)和不积极坐着)。主要活动包括体育比赛。在3个阶段(测试前(禁食)、比赛后和恢复后)采集血样。本研究采用单因素方差分析，采用SPSS v. 22统计软件对数据进行检验(P0.05的显著性水平)，但通过按摩回收对剧烈运动后醛缩酶水平有降低作用。三种循环方法(被动、慢跑、按摩)在减少白细胞和血红蛋白数量方面有显著差异，按摩组有利于恢复。结论根据结果，可以说在各种恢复方法中，使用按摩对降低女运动员跑步比赛后醛缩酶活性更为有效。
{"title":"Effect of Three Different Types Of Recovery After Intensive Training on the Aldolase Level and Some Hematological Indicatorsin Female Runners","authors":"M. Rahmani Ghobadi, Seyyed Ali Hoseini, Ghobad Hasanpour","doi":"10.32598/jsmj.21.1.2711","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2711","url":null,"abstract":"Background and Objectives The aim of this study was to Acute changes in aldolase activity and some hematologic parameters compared to different recoveries. Subjects and Methods The research is of applied type and quasi-experimental research method which was conducted in field-laboratory form with pre-test-post-test design with control group on female semiprofessional athletes in athletics (runners) in Tehran. Sampling was done by simple random sampling, so that after informing and inviting interested people and passing the preliminary stages, 30 runners were selected as the research sample and randomly in 3 groups of 10 people (active recycling group (running), inactivated recycling group (sports massage) and inactive sitting). The main activity included a sports competition. Blood samples were taken from the samples in 3 stages (pre-test (fasting), post-race and post-recovery). In this study, one-way analysis of variance and SPSS statistical software v. 22 were used to examine the data at a significance level of P<0.05. Results The results of this study showed that there is no significant difference between the three types of recycling methods in changing the amount of aldolase and erythrocyte factors (P>0.05), but recycling by massage has an effect on reducing aldolase levels after strenuous exercise. There is a significant difference between the three types of recycling methods (passive, jogging, massage) in reducing the number of white blood cells and hemoglobin in favor of recovery by the massage group. Conclusion According to the results, it can be said that among the recovery methods, the use of massage was more effective in reducing the aldolase activity of female athletes after the run competition.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"PP 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84165059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roghayeh Eslami, H. Ebrahimi, Solmaz Talebi, Mehdi Mansouri, Hossein Bagheri
Background and Objectives Due to the high rate of inhalers’ incorrect use by the elderly, this study aims to evaluate the effect of teaching the use of inhalers to a family caregiver on its correct use by the elderly patients. Subjects and Methods This is a parallel-group randomized clinical trial on 80 older people with a lung disease aged >60 years who use the inhaler incorrectly and their family caregivers. Participants were randomly assigned to group A (education) and group B (control) using a block randomization method (4×4 blocks). In group A, teaching of the correct use of inhaler was provided to the caregivers of the elderly orally and practically in one session, while in group B, training was provided only to the elderly. Three weeks later, the two groups were evaluated using a researcher-made inhaler use checklist. Results There was no significant difference in the use of inhaler before and after the intervention in group A (2.58±1.26) and B (2.55±1.22) (P<0.05). Pearson correlation test results showed a significant decrease in the correct use of inhaler with the increase of patients’ age (r=-0.24). Conclusion Further studies on the use of family members in elderly patients care, various educational programs by health care providers, and periodic evaluation of the performance of the elderly regarding the use of inhalers are recommended.
{"title":"The Effect of Teaching the Use of Inhaler to a Family Caregiver on its Correct Use By the Elderly Patients: A Randomized Clinical Trial","authors":"Roghayeh Eslami, H. Ebrahimi, Solmaz Talebi, Mehdi Mansouri, Hossein Bagheri","doi":"10.32598/jsmj.21.1.2251","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2251","url":null,"abstract":"Background and Objectives Due to the high rate of inhalers’ incorrect use by the elderly, this study aims to evaluate the effect of teaching the use of inhalers to a family caregiver on its correct use by the elderly patients. Subjects and Methods This is a parallel-group randomized clinical trial on 80 older people with a lung disease aged >60 years who use the inhaler incorrectly and their family caregivers. Participants were randomly assigned to group A (education) and group B (control) using a block randomization method (4×4 blocks). In group A, teaching of the correct use of inhaler was provided to the caregivers of the elderly orally and practically in one session, while in group B, training was provided only to the elderly. Three weeks later, the two groups were evaluated using a researcher-made inhaler use checklist. Results There was no significant difference in the use of inhaler before and after the intervention in group A (2.58±1.26) and B (2.55±1.22) (P<0.05). Pearson correlation test results showed a significant decrease in the correct use of inhaler with the increase of patients’ age (r=-0.24). Conclusion Further studies on the use of family members in elderly patients care, various educational programs by health care providers, and periodic evaluation of the performance of the elderly regarding the use of inhalers are recommended.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90215596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kimia Moiniafshari, M. Gholami, Hamid Dalvand, M. Effatpanah, Saeed Rezaei
Background and Objectives Autism spectrum disorder (ASD) is a neuro-developmental disorder which is mostly caused by deficits in social interactions. Lack of physical activity and poor nutritional habits are common problems in these patients which may be exaggerated by the Covid-19 pandemic. The study aims to assess the effect of functional training along with online nutrition education on inflammatory biomarkers in children with ASD. Subjects and Methods In this randomized controlled clinical trial, 80 children with ASD (age=9.73±1.29 years, weight=49.94±2.08 kg, height=146.08±40 cm, body mass index=24.71 ±1.48 kg/m2) were randomly divided into four groups of training, education, training+ education, and control. The interventions lasted for 8 weeks. The inflammatory biomarkers including white blood cell (WBC) count, C-reactive protein (CRP) level, neutrophil count, eosinophil count, and basophil count were assessed (using blood samples collected from antecubital vein) before and after the interventions. Results There was no significant difference between the groups before the interventions (P˃0.05). After the intervention, the results showed a significant decrease in WBC (P˂0.001), CRP (P=0.001), neutrophils (sig.=0.009), and eosinophil (P=0.003) in all groups. Basophil count decreased in all groups (P=0.01) except in the education group. Conclusion Functional training and online nutrition education are beneficial interventions for management of inflammatory biomarkers in children with ASD which can be used during the Covid-19 pandemic.
{"title":"The Effect of Functional Exercise Along With Online Nutritional Education on Inflammatory Biomarkers in Children With Autism Spectrum Disorder During Covid-19 Pandemic: A Randomized Clinical Trial","authors":"Kimia Moiniafshari, M. Gholami, Hamid Dalvand, M. Effatpanah, Saeed Rezaei","doi":"10.32598/JSMJ.21.1.2724","DOIUrl":"https://doi.org/10.32598/JSMJ.21.1.2724","url":null,"abstract":"Background and Objectives Autism spectrum disorder (ASD) is a neuro-developmental disorder which is mostly caused by deficits in social interactions. Lack of physical activity and poor nutritional habits are common problems in these patients which may be exaggerated by the Covid-19 pandemic. The study aims to assess the effect of functional training along with online nutrition education on inflammatory biomarkers in children with ASD. Subjects and Methods In this randomized controlled clinical trial, 80 children with ASD (age=9.73±1.29 years, weight=49.94±2.08 kg, height=146.08±40 cm, body mass index=24.71 ±1.48 kg/m2) were randomly divided into four groups of training, education, training+ education, and control. The interventions lasted for 8 weeks. The inflammatory biomarkers including white blood cell (WBC) count, C-reactive protein (CRP) level, neutrophil count, eosinophil count, and basophil count were assessed (using blood samples collected from antecubital vein) before and after the interventions. Results There was no significant difference between the groups before the interventions (P˃0.05). After the intervention, the results showed a significant decrease in WBC (P˂0.001), CRP (P=0.001), neutrophils (sig.=0.009), and eosinophil (P=0.003) in all groups. Basophil count decreased in all groups (P=0.01) except in the education group. Conclusion Functional training and online nutrition education are beneficial interventions for management of inflammatory biomarkers in children with ASD which can be used during the Covid-19 pandemic.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77275042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamal Rasoulpour, Hadi Gharani, Aziz Zinvand Lourestani, V. Taeid, MohammadReza Zoalfaghari, Najmedin Espandar, Jalal Shirazd
Background and Objectives Caffeine is a purine alkaloid with anti-oxidant and anti-inflammatory effects. This study aims to evaluate the effect of long-term caffeine consumption and aerobic exercise on serum interleukin-6 (IL-6) level and body composition in obese men. Subjects and Methods In this quasi-experimental study, 40 obese men (Mean age=32.8±2.74 years, body mass index=30.98±1.37 kg/m2) were randomly divided into four Group of 10 including placebo, supplementation, placebo + exercise, and supplementation + exercise. The aerobic exercise program included running for 8 weeks, 3 sessions per week, each for 25-45 minutes with an intensity of 55-85% of the maximum heart rate. The supplementation group received 500 mg caffeine daily and the placebo group received 500 mg capsules of 2% maltodextrin. Blood samples were taken following 12 hours of fasting before and 48 hours after the last training session to measure IL-6 level. Data were analyzed using oneway ANOVA and Tukey’s post hoc test. The significance level was set 0.05. Results In the exercise+supplementation and placebo+exercise groups significant decreases were reported in the serum level of IL-6 compared to the supplementation and placebo groups in the post-test phase (P<0.05). There was also a significant decrease in body composition of groups placebo+exercise, exercise+supplementation, and supplementation compared to placebo group in the post-test phase (P<0.05). Conclusion Aerobic exercise alone and in combination with long-term caffeine consumption can reduce IL-6 level and improve body composition in obese people.
{"title":"Comparing of The Effect of Long-Term Caffeine Consumption Combined With Aerobic Exercise on Serum Interleukin-6 Level and Body Composition in Obese Men","authors":"Jamal Rasoulpour, Hadi Gharani, Aziz Zinvand Lourestani, V. Taeid, MohammadReza Zoalfaghari, Najmedin Espandar, Jalal Shirazd","doi":"10.32598/jsmj.21.1.2481","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2481","url":null,"abstract":"Background and Objectives Caffeine is a purine alkaloid with anti-oxidant and anti-inflammatory effects. This study aims to evaluate the effect of long-term caffeine consumption and aerobic exercise on serum interleukin-6 (IL-6) level and body composition in obese men. Subjects and Methods In this quasi-experimental study, 40 obese men (Mean age=32.8±2.74 years, body mass index=30.98±1.37 kg/m2) were randomly divided into four Group of 10 including placebo, supplementation, placebo + exercise, and supplementation + exercise. The aerobic exercise program included running for 8 weeks, 3 sessions per week, each for 25-45 minutes with an intensity of 55-85% of the maximum heart rate. The supplementation group received 500 mg caffeine daily and the placebo group received 500 mg capsules of 2% maltodextrin. Blood samples were taken following 12 hours of fasting before and 48 hours after the last training session to measure IL-6 level. Data were analyzed using oneway ANOVA and Tukey’s post hoc test. The significance level was set 0.05. Results In the exercise+supplementation and placebo+exercise groups significant decreases were reported in the serum level of IL-6 compared to the supplementation and placebo groups in the post-test phase (P<0.05). There was also a significant decrease in body composition of groups placebo+exercise, exercise+supplementation, and supplementation compared to placebo group in the post-test phase (P<0.05). Conclusion Aerobic exercise alone and in combination with long-term caffeine consumption can reduce IL-6 level and improve body composition in obese people.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74237952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this case report study, the patient was a 95-year-old woman who was referred to the health center due to inability to swallow liquids and solids for 6 months. After determining the cause of dysphagia due to a large Zenker’s diverticulum in the initial part of the esophagus, and the inability of patient to tolerate surgery due to her age and general deterioration, she underwent the endoscopic diverticulectomy. Under a two-hour endoscopic surgery, the wall of the cricopharyngeal muscle was first identified and diverticulectomy was performed by cutting the muscle with an endoscopic needle knife, using the Olympus flexible endoscope and closing the surgery site with clips. There were no complications during or after the surgery. The patient was kept fasting for 48 hours. After that, liquid feeding was started; 5 days later, the patient was discharged from the hospital with a good general condition and the ability to swallow food. This was the first case of endoscopic diverticulectomy in the southwest of Iran.
{"title":"The First Endoscopic Diverticulectomy for a Large Zenker’s Esophageal Diverticula in Southwest of Iran: A Case Report","authors":"P. Alavinejad, Azam Sattari, S. Mohammadi","doi":"10.32598/jsmj.21.1.2667","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2667","url":null,"abstract":"In this case report study, the patient was a 95-year-old woman who was referred to the health center due to inability to swallow liquids and solids for 6 months. After determining the cause of dysphagia due to a large Zenker’s diverticulum in the initial part of the esophagus, and the inability of patient to tolerate surgery due to her age and general deterioration, she underwent the endoscopic diverticulectomy. Under a two-hour endoscopic surgery, the wall of the cricopharyngeal muscle was first identified and diverticulectomy was performed by cutting the muscle with an endoscopic needle knife, using the Olympus flexible endoscope and closing the surgery site with clips. There were no complications during or after the surgery. The patient was kept fasting for 48 hours. After that, liquid feeding was started; 5 days later, the patient was discharged from the hospital with a good general condition and the ability to swallow food. This was the first case of endoscopic diverticulectomy in the southwest of Iran.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87980204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zakiye Davar, I. Jafari Anarkooli, Mohammadjavad Fridoni, A. Abdanipour
Background and Objectives Uncontrolled stress affects hippocampal-dependent memory through altering the morphology and the proliferation rate of hippocampal progenitor cells. Subjects and Methods In this experimental study, neural stem cells (NSCs) were isolated from the hippocampus of newborn rats and cultivated in a serum-free medium to generate neurosphere. To confirm the induced NSCs, immunocytochemistry and antibody nestin were used. The rate of cell proliferation and cytotoxicity caused by norepinephrine were measured by the MTT assay. NSCs were assigned in the following groups: Control (untreated NSCs), norepinephrine (NSCs treated with norepinephrine), propranolol (NSCs treated with beta receptor blocker propranolol plus norepinephrine), prazosin (NSCs treated with Alfa receptor blocker prazosin plus norepinephrine), and propranolol/ prazosin (NSCs treated with both propranolol and prazosin plus norepinephrine). Real-time PCR was conducted to measure the expression levels of Stk4, Caspase-3 and Sox2 genes. Results The flow cytometry study revealed that NSCs were nestin positive. Real-time PCR results showed that the expression level of Sox2 gene increased by norepinephrine. In addition, the expression level of Stk4 and Caspase-3 genes increased in the groups treated with prazosin. Conclusion The effect of norepinephrine on hippocampus-derived NSCs is receptor-dependent. The increase of norepinephrine under chronic stress can lead to either cell proliferation or apoptosis in NSCs; it acts as a double-edged sword.
{"title":"Effect of Alpha and Beta Adrenergic Receptors on the Expression of Stk4, Caspase-3, and Sox2 Genes in Neural Stem Cells Derived From the Hippocampus and Treated With Norepinephrine in Rats","authors":"Zakiye Davar, I. Jafari Anarkooli, Mohammadjavad Fridoni, A. Abdanipour","doi":"10.32598/jsmj.21.1.2815","DOIUrl":"https://doi.org/10.32598/jsmj.21.1.2815","url":null,"abstract":"Background and Objectives Uncontrolled stress affects hippocampal-dependent memory through altering the morphology and the proliferation rate of hippocampal progenitor cells. Subjects and Methods In this experimental study, neural stem cells (NSCs) were isolated from the hippocampus of newborn rats and cultivated in a serum-free medium to generate neurosphere. To confirm the induced NSCs, immunocytochemistry and antibody nestin were used. The rate of cell proliferation and cytotoxicity caused by norepinephrine were measured by the MTT assay. NSCs were assigned in the following groups: Control (untreated NSCs), norepinephrine (NSCs treated with norepinephrine), propranolol (NSCs treated with beta receptor blocker propranolol plus norepinephrine), prazosin (NSCs treated with Alfa receptor blocker prazosin plus norepinephrine), and propranolol/ prazosin (NSCs treated with both propranolol and prazosin plus norepinephrine). Real-time PCR was conducted to measure the expression levels of Stk4, Caspase-3 and Sox2 genes. Results The flow cytometry study revealed that NSCs were nestin positive. Real-time PCR results showed that the expression level of Sox2 gene increased by norepinephrine. In addition, the expression level of Stk4 and Caspase-3 genes increased in the groups treated with prazosin. Conclusion The effect of norepinephrine on hippocampus-derived NSCs is receptor-dependent. The increase of norepinephrine under chronic stress can lead to either cell proliferation or apoptosis in NSCs; it acts as a double-edged sword.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75972751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：