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Effectiveness of the Camperdown Program in Reducing Stuttering Severity of Kurdish-speaking Adolescents With Stuttering in Iran 坎珀唐计划在降低伊朗库尔德语青少年口吃严重程度方面的效果
Pub Date : 2023-07-01 DOI: 10.32598/jsmj.21.6.2818
B. Shafiei, Zahra Dindoust, Hamid Karimi
Background and Objectives Stuttering, due to different reactions of stutterers in different ages, needs age-specific treatment. Considering the lack of study on the effect of the Camperdown program on treatment of stuttering in adolescents in Iran, the present study aims to investigate the effect of the Camperdown program on the stuttering severity of Kurdish-speaking adolescents with stuttering in Iran. Subjects and Methods This is a single-subject study with an A-B-A design which was conducted on 4 Kurdish-speaking adolescents with stuttering. The pre-test assessments were first done. Then, they received 40 sessions of intervention using the Camperdown program. The measures were was the percentage of stuttered syllables, the 9-point severity rating scale, and the speech naturalness scale (NAT). The data were analyzed based on visual analysis and descriptive statistics. Results The intervention was effective in reducing the stuttering severity of all four subjects (percentage of non-overlapping data=100%) and the scores of NAT scale in subjects after intervention was significantly different from their pre-intervention scores. Conclusion The Camperdown program is effective in reducing the stuttering severity of Kurdish-speaking adolescents with stuttering.
背景和目的 由于口吃患者在不同年龄段的反应不同,因此需要针对不同年龄段进行治疗。考虑到缺乏有关坎培尔顿计划对伊朗青少年口吃治疗效果的研究,本研究旨在调查坎培尔顿计划对伊朗库尔德语青少年口吃严重程度的影响。研究对象与方法 这是一项采用A-B-A设计的单个研究对象研究,研究对象为4名库尔德语口吃青少年。首先进行测试前评估。然后,他们接受了 40 个疗程的康普顿项目干预。测量指标包括口吃音节百分比、9 点严重程度评分量表和言语自然度量表(NAT)。数据分析基于视觉分析和描述性统计。结果 干预有效降低了所有四名受试者的口吃严重程度(无重叠数据百分比=100%),受试者干预后的NAT量表得分与干预前的得分有显著差异。结论 坎珀唐计划能有效降低库尔德语青少年口吃的严重程度。
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引用次数: 0
Evaluation of operations and causes of corneal transplantation in patients referred to the ophthalmology ward of Imam Khomeini Hospital in Ahvaz 2003 to 2019 2003 年至 2019 年阿瓦士伊玛目霍梅尼医院眼科病房转诊患者角膜移植手术和原因评估
Pub Date : 2023-07-01 DOI: 10.32598/jsmj.21.6.2787
F. Ostadian, Mahmoud Reza Panahi Bazzaz, Vahid Shahsavari, M. S. Mirdehghan
Introduction: Corneal transplantation is one of the most common eye surgeries and the most common and successful tissue transplant in the world. The aim of this study was to determine the frequency of causes and types of corneal transplantation in patients referred to the ophthalmology ward of Imam Khomeini Hospital in Ahvaz from 2003 to 2018. Methods: This descriptive study was performed on the records of the patients who underwent corneal transplantation. The information included age, sex, cause of transplantation, sex and age of the donor, need for re-transplantation, reason for re-transplantation, laterality of cornea and the type of operation. Results: The mean age of patients receiving cornea was 50.93 years and included 491 (49.3%) male and 505 (50.7%) female. 51.7% of corneal transplant operations were related to the right eye and 47.9% of the operations were related to the left eye respectively. PBK was the most cause of corneal transplantation. Most patients underwent corneal transplantation by PK and then DSAEK. Conclusion: Frequency of PBK was increased in this study as compare to other previous studies which may be due to significant increase in the rate of phacoemulsification surgeries. DSEAK and DMEAK have become more accepted and favorable surgeries in the case of corneal endothelial disease. Based on new surgical techniques and advances in post of management we suggest, new meta-analysis study to evaluate associated diseases , comparison of the regraft rate in different surgical techniques and post op management of them.
简介角膜移植是最常见的眼科手术之一,也是世界上最常见、最成功的组织移植手术。本研究旨在确定 2003 年至 2018 年期间转诊至阿瓦士伊玛目霍梅尼医院眼科病房的患者角膜移植的原因和类型的频率。方法:本描述性研究针对接受角膜移植手术的患者记录进行。信息包括年龄、性别、移植原因、供体的性别和年龄、再次移植的需求、再次移植的原因、角膜侧位和手术类型。结果接受角膜移植的患者平均年龄为 50.93 岁,其中男性 491 人(占 49.3%),女性 505 人(占 50.7%)。51.7%的角膜移植手术与右眼有关,47.9%的角膜移植手术与左眼有关。PBK是导致角膜移植手术最多的原因。大多数患者都是先进行PK角膜移植手术,然后再进行DSAEK角膜移植手术。结论与之前的其他研究相比,本研究中PBK的发生率有所上升,这可能是由于超声乳化手术的比例显著增加所致。DSEAK和DMEAK已成为角膜内皮疾病患者较为接受和青睐的手术方式。基于新的手术技术和术后管理的进步,我们建议进行新的荟萃分析研究,以评估相关疾病、比较不同手术技术的再植率和术后管理。
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引用次数: 0
Prediction of Preterm Delivery From the Endocervical Length at 11 to 14 Weeks 从11 ~ 14周宫颈长度预测早产
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2741
Mohammad Nilchian, A. Adibi, M. Mansourian
Background and Objectives Premature delivery is called delivery before 37 weeks. It is estimated that every year, about 15 million babies are born with preterm delivery worldwide, which is approximately equal to 11% of the total number of deliveries. In this study, a number of pregnant women with 11-14 weeks of pregnancy were evaluated in order to evaluate the value of cervical length at the end of the first trimester of pregnancy in predicting preterm delivery. Subjects and Methods In this cohort study, 156 asymptomatic pregnant women with a gestational age of 11-14 weeks were randomly selected and evaluated. Cervical length was measured by transvaginal ultrasound using a standard method. Cervical length and gestational age at delivery were recorded in a computer database along with demographic information, clinical history, and pregnancy information. Results The mean length of the cervix in women with preterm delivery was 31.32±6.71 mm and in women with term delivery was 38.96±5.80 mm. Data analysis showed that shorter cervical length was significantly associated with preterm delivery. With a threshold of 34.5 mm, the length of the cervix from 3rd month to 6th month could predict preterm delivery with a sensitivity of 76% and a specificity of 81%. Conclusion Measuring cervical length with transvaginal ultrasound in the second trimester can predict preterm delivery.
背景与目的早产称为37周前分娩。据估计,全世界每年约有1500万婴儿早产,约占分娩总数的11%。在本研究中,我们对一些怀孕11-14周的孕妇进行了评估,以评估妊娠前三个月末宫颈长度在预测早产中的价值。在这项队列研究中,随机选择156名胎龄为11-14周的无症状孕妇进行评估。采用标准方法经阴道超声测量宫颈长度。子宫颈长度和分娩时的胎龄连同人口统计信息、临床病史和妊娠信息一起记录在计算机数据库中。结果早产组宫颈平均长度为31.32±6.71 mm,足月组宫颈平均长度为38.96±5.80 mm。资料分析显示,宫颈长度较短与早产显著相关。3 ~ 6月宫颈长度预测早产的阈值为34.5 mm,敏感性为76%,特异性为81%。结论妊娠中期经阴道超声测量宫颈长度可预测早产。
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引用次数: 0
A Review of the Effectiveness of Exercise Protocols on Proprioception and Pain in People With Nonspecific Chronic Low Back Pain 运动方案对非特异性慢性腰痛患者本体感觉和疼痛的影响综述
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2784
M. Amini, M. Alizadeh, M. Sahebozamani, M. Akochakian
Background and Objectives Chronic low back pain is one of the most common and costly musculoskeletal disorders in societies and is an important clinical and socio-economic epidemic, mostly in industry and non-industry. The aim of this study was to a systematic review of the effectiveness of exercise protocols on lumbar proprioception in patients with chronic nonspecific low back pain. Subjects and Methods From internal and external search engines, including Scopus, Semantic Scholar, Google Scholar, Pubmed, ISC, SID, Magiran, Irandoc, and Doaj with time limit 2010 to 2021 and the keywords exercises, proprioception, non-specific, and chronic low back pain, the present study was done using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes). Results Nine articles were selected based on inclusion criteria. These studies mainly focused on systematic review effectiveness of exercise protocols on sensation and low back pain in people with non-specific chronic low back pain. Conclusion According to the research reviewed in the present study, it seems that exercise rehabilitation protocols activate, strengthen, maintain, and increase the central region of the body, especially deep muscles, particularly the multifidus and transverse abdomen, by retraining the pelvic lumbar region. The diaphragm and diagonal of the abdomen and pelvic floor, which play a role in the important segmental stability of the lumbar spine, improve the sense of depth and pain in patients with chronic nonspecific low back pain.
背景和目的慢性腰痛是社会上最常见和最昂贵的肌肉骨骼疾病之一,是一种重要的临床和社会经济流行病,主要发生在工业和非工业中。本研究的目的是系统回顾运动方案对慢性非特异性腰痛患者腰椎本体感觉的有效性。本研究采用PRISMA (Preferred Reporting Items for Systematic Reviews and meta - analysis),从Scopus、Semantic Scholar、Google Scholar、Pubmed、ISC、SID、Magiran、Irandoc、Doaj等国内外搜索引擎检索,检索时间限定为2010 - 2021年,检索关键词为exercises、proprioception、non-specific、chronic腰痛。结果根据纳入标准筛选出9篇文献。这些研究主要集中在系统评价运动方案对非特异性慢性腰痛患者的感觉和腰痛的有效性。根据本研究回顾的研究,运动康复方案似乎通过再训练骨盆腰椎区来激活、加强、维持和增加身体的中央区域,特别是深部肌肉,特别是多裂肌和腹横肌。腹部和盆底膈肌和对角线对腰椎的重要节段稳定性起作用,可改善慢性非特异性腰痛患者的深度感和疼痛感。
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引用次数: 0
Relationship Between Candida Albicans Fungal Colonies From the Infant’s Mouth and Mother’s Nipple 婴儿口腔和母亲乳头白色念珠菌菌落的关系
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2527
Samaneh Aghighi Hatamipour, K. Kheirollahi, Mahin Ghafur Zadeh
Background and Objectives Early diagnosis and appropriate treatment of candidiasis in the infant’s mouth and nipple of breastfeeding mothers can have positive effects on the infant’s nutrition from the mother’s milk. Therefore, the aim of this study was to investigate the prevalence of Candida albicans fungal colonies in the infant’s oral cavities and nipples of breastfeeding mothers. Subjects and Methods This cross-sectional study was performed on 98 breastfeeding mothers and their healthy infants. Samples were taken from the posterior area of the infant’s tongue and the nipple of the breastfeeding mothers. Samples were transferred to a dextrose agar medium containing 0.05% chloramphenicol in the laboratory and were kept at 30 ° C for 48 hours and then the number of Candida colonies was counted and recorded. The data were analyzed by SPSS 17 statistical software and t-test and Pearson correlation coefficient. Results The mean number of cultured colonies from infants’ mouths and nipples of breastfeeding mothers was 64.44±42.99 and 102.62±63.56, respectively. In neonates born by cesarean section and nipple of their mothers, there were significantly more Candida colonies (P<0.05). There was a positive and significant correlation between the number of cultured colonies from the nipple of breastfeeding mothers and the infant’s mouth (P=0.000, r=0.796). Conclusion Candida culture was positive in more than half of the samples both in the mouth of the infant and in their mothers’ nipples.
背景与目的早期诊断和适当治疗母乳喂养母亲的婴儿口腔和乳头念珠菌病可对婴儿从母乳中获得的营养产生积极影响。因此,本研究的目的是调查白色念珠菌菌落在母乳喂养的母亲的婴儿口腔和乳头的患病率。研究对象和方法本研究对98名母乳喂养的母亲及其健康婴儿进行了横断面研究。样本取自母乳喂养母亲的婴儿舌头后部和乳头。在实验室将样品转移到含有0.05%氯霉素的葡萄糖琼脂培养基中,在30℃下保存48小时,计数并记录假丝酵母菌落数。数据采用SPSS 17统计软件进行分析,采用t检验和Pearson相关系数。结果母乳喂养母亲口腔和乳头培养菌落的平均数量分别为64.44±42.99个和102.62±63.56个。剖宫产和母亲乳头出生的新生儿念珠菌菌落数量显著高于对照组(P<0.05)。乳母乳头培养菌落数量与婴儿口腔培养菌落数量呈显著正相关(P=0.000, r=0.796)。结论半数以上婴儿口腔及母亲乳头标本念珠菌培养阳性。
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引用次数: 0
The Effect of Aerobic Activity on Changes in Cystatin C and Homocysteine Levels as Cardiovascular Risk Factors 有氧运动对半胱氨酸C和同型半胱氨酸水平变化的影响
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2521
M. Porsesh, A. Habibi, S. Barati
Background and Objectives Chronic inflammation is associated with the development of various diseases, including atherosclerosis and diabetes. The aim of this study was to investigate the effect of longterm selected aerobic exercises on changes in cystatin C and homocysteine in inactive and overweight middle-aged women. Subjects and Methods Thirty non-athlete middle-aged women (mean age: 46.06±6.97 years, weight: 71.82±9.11 kg, height: 156.9±5.24 cm, and body mass index: 29.2±4.11kg/m2) voluntarily participated in this project and were randomly divided into the experimental and control groups The experimental group performed selected aerobic exercises (65-75% of maximum heart rate) for eight weeks. Blood samples were taken before and 24 hours after the completion of the research protocol to measure the levels of cystatin C and homocysteine. Analysis of covariance was used for intergroup comparisons and paired t-test was used for intergroup comparisons. Results The results showed that there was no significant difference between the experimental and control groups in cystatin C (P=0.09) and homocysteine (P=0.07) after eight weeks of selected aerobic exercises. A significant decrease was observed in weight (P=0.001) and body mass index (P=0.002) in the experimental group compared to the control group. Conclusion Overall, the results of the present study showed that although the eight-week activity program improved the body composition of overweight middle-aged women, longer periods of aerobic exercise are required to examine clearer biochemical results.
背景与目的慢性炎症与多种疾病的发展有关,包括动脉粥样硬化和糖尿病。本研究的目的是调查长期选择性有氧运动对不运动和超重中年妇女胱抑素C和同型半胱氨酸变化的影响。研究对象与方法30名非运动员中年女性自愿参加本研究,平均年龄46.06±6.97岁,体重71.82±9.11 kg,身高156.9±5.24 cm,体重指数29.2±4.11kg/m2,随机分为实验组和对照组。实验组进行选择性有氧运动(最大心率65-75%),为期8周。在研究方案完成前和完成后24小时采集血样,测量胱抑素C和同型半胱氨酸的水平。组间比较采用协方差分析,组间比较采用配对t检验。结果结果显示,经过8周的有氧运动,实验组与对照组胱抑素C (P=0.09)和同型半胱氨酸(P=0.07)无显著差异。与对照组相比,实验组的体重(P=0.001)和体重指数(P=0.002)均有显著下降。总的来说,本研究的结果表明,尽管8周的运动计划改善了超重中年妇女的身体成分,但需要更长的有氧运动时间来检验更清晰的生化结果。
{"title":"The Effect of Aerobic Activity on Changes in Cystatin C and Homocysteine Levels as Cardiovascular Risk Factors","authors":"M. Porsesh, A. Habibi, S. Barati","doi":"10.32598/jsmj.21.3.2521","DOIUrl":"https://doi.org/10.32598/jsmj.21.3.2521","url":null,"abstract":"Background and Objectives Chronic inflammation is associated with the development of various diseases, including atherosclerosis and diabetes. The aim of this study was to investigate the effect of longterm selected aerobic exercises on changes in cystatin C and homocysteine in inactive and overweight middle-aged women. Subjects and Methods Thirty non-athlete middle-aged women (mean age: 46.06±6.97 years, weight: 71.82±9.11 kg, height: 156.9±5.24 cm, and body mass index: 29.2±4.11kg/m2) voluntarily participated in this project and were randomly divided into the experimental and control groups The experimental group performed selected aerobic exercises (65-75% of maximum heart rate) for eight weeks. Blood samples were taken before and 24 hours after the completion of the research protocol to measure the levels of cystatin C and homocysteine. Analysis of covariance was used for intergroup comparisons and paired t-test was used for intergroup comparisons. Results The results showed that there was no significant difference between the experimental and control groups in cystatin C (P=0.09) and homocysteine (P=0.07) after eight weeks of selected aerobic exercises. A significant decrease was observed in weight (P=0.001) and body mass index (P=0.002) in the experimental group compared to the control group. Conclusion Overall, the results of the present study showed that although the eight-week activity program improved the body composition of overweight middle-aged women, longer periods of aerobic exercise are required to examine clearer biochemical results.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88742274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Different Recovery Methods on Oxidative Stress and Hematological Indicators in Female Runners 不同恢复方式对女性跑步者氧化应激及血液学指标的影响
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2826
Marya Rahmani Ghobadi, S. Hoseini, Ghobad Hasanpour
Background and Objectives Exercise can increase oxidative and metabolic stress. The aim of this research was to investigate the effect of different recovery methods after an acute training session on aspartate aminotransferase activity, oxidative stress, and some hematological indices of female runners. Subjects and Methods In the present quasi-experimental study, 30 semi-professional female runners were selected as the research sample and randomly divided into three groups (n=10): active running recovery, passive recovery, and sports massage. After two weeks, the same training protocol was performed for athletes and also after a week of rest, fasting blood sampling was performed. Blood sampling was performed in three stages: 1- fasting, 2- after 1500 meters competition, and 3- immediately after different stages of recovery. The one-way analysis of variance was used for statistical analysis. Results The results showed that in the massage group, the change in hematocrit, white blood cells, and hemoglobin was more than in the active and inactive recovery group (P<0.05), while in the active recovery group, the level of malondialdehyde decreased more than the massage and inactive recovery groups (P<0.05). There was no significant difference between the three recovery methods on changes in iron, red blood cells, aspartate aminotransferase, and total antioxidant capacity (P<0.05). Conclusion According to the results, it can be said that active recovery can prevent damage caused by oxidative stress by increasing blood flow.
运动可以增加氧化应激和代谢应激。本研究旨在探讨急性训练后不同的恢复方式对女性跑步者的天冬氨酸转氨酶活性、氧化应激和一些血清学指标的影响。本准实验研究选取30名半职业女性跑步者作为研究样本,随机分为主动跑步恢复组、被动跑步恢复组和运动按摩组3组(n=10)。两周后,对运动员进行相同的训练方案,休息一周后,进行空腹血液采样。采血分三个阶段进行:1-禁食,2- 1500米比赛后,3-不同恢复阶段后立即采血。统计分析采用单因素方差分析。结果显示,按摩组大鼠红细胞压积、白细胞、血红蛋白的变化均大于活跃和不活跃恢复组(P<0.05),而活跃恢复组大鼠丙二醛水平下降幅度大于按摩和不活跃恢复组(P<0.05)。三种恢复方法对铁、红细胞、天冬氨酸转氨酶和总抗氧化能力的影响差异无统计学意义(P<0.05)。结论主动恢复可以通过增加血流量来预防氧化应激引起的损伤。
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引用次数: 0
Evaluation of Job Stress and Its Related Factors in Operating Room Staff in the COVID-19 Pandemic in Hospitals of Guilan Province in 2021 桂兰省医院2021年新冠肺炎疫情手术室工作人员工作压力及相关因素评价
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2763
Reza Salehinia, Ebrahim Nasiri Formi, H. B. Derakhshan, Reza Pourmohammad
Background and Objectives Health workers are at the forefront in the diagnosis, treatment, and care of patients with COVID-19, which can increase the psychological burden, stress, and anxiety of staff. The purpose of this study was to determine job stress and related factors of the operating room staff during the COVID-19 pandemic. Subjects and Methods This descriptive study was performed on the operating room staff of hospitals in Guilan province in 2021. The variables evaluated in this study included the relationship between age, gender, marital status, level of education, the field of study, employment status, and anxiety. In order to collect data in this study, the standard SPIO job stress questionnaire was used and the data were analyzed using an independent t-test. Results In this study, 120 people in the age range of 47-23 with a mean age of 31.47±8.79 years participated. Men had less stress than women and married people showed more stress. In terms of job status, officially employed people had the least stress and people who served in the military had the most stress. In terms of field of study, anesthesiologists showed the highest stress level, and the operating room had the lowest score. In terms of education level, those with a master’s degree had the highest score, and those with an associate degree showed the lowest score. Conclusion The results of this study showed that with age, job stress also increases and in terms of gender, women had more stress. In terms of marriage, married people showed more stress, which could be due to having a family and the stress of the family being infected with the virus. In terms of job status, officially employed people showed less stress, in terms of field of study, people with a degree in anesthesia had more stress, and in terms of education, people with a higher degree showed more stress.
背景和目的卫生工作者在COVID-19患者的诊断、治疗和护理中处于第一线,这可能会增加工作人员的心理负担、压力和焦虑。本研究的目的是了解COVID-19大流行期间手术室工作人员的工作压力及其相关因素。对象与方法本描述性研究以贵州省2021年医院手术室工作人员为研究对象。本研究评估的变量包括年龄、性别、婚姻状况、教育程度、学习领域、就业状况和焦虑之间的关系。为了收集本研究的数据,采用标准的SPIO工作压力问卷,并采用独立t检验对数据进行分析。结果本研究共纳入120例患者,年龄47 ~ 23岁,平均年龄31.47±8.79岁。男性的压力比女性小,已婚人士的压力更大。在工作状态方面,正式雇员的压力最小,而在军队服役的人的压力最大。在学习领域方面,麻醉医师的压力水平最高,手术室的压力水平最低。从教育程度来看,硕士学位的人得分最高,副学士学位的人得分最低。结论本研究结果表明,随着年龄的增长,工作压力也在增加,从性别上看,女性的压力更大。在婚姻方面,已婚人士表现出更大的压力,这可能是由于有家庭以及家庭感染病毒的压力。在工作状态方面,正式就业的人压力较小,在研究领域方面,拥有麻醉学位的人压力较大,在教育程度方面,拥有较高学位的人压力较大。
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引用次数: 0
Evaluation of the Status of Intraparenchymal Plasma Cells in Terms of IgG4 Expression in Patients Diagnosed With Idiopathic Granulomatous Mastitis 特发性肉芽肿性乳腺炎患者肝实质内浆细胞IgG4表达状况的评价
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.1.2590
S. Taghipour zahir, K. Rahmani, M. Vakili
Background and Objectives Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory lesion that mimics the clinical symptoms of carcinoma. Another type of chronic granulomatous mastitis is immunological mastitis, which is related to the infiltration of IgG4 plasma cells. This study aims to determine the status of IgG4 positive plasma cells in IGM samples. Subjects and Methods This is an analytical-cross-sectional study. 46 women diagnosed with IGM were selected for the study using census method. The percentage of IgG and IgG4 in plasma cells was determined based on immunohistochemical method. Age and type of surgery were also recorded. The data was entered into SPSS software, version 22 and analyzed using statistical tests. P<0.05 were considered statistically significant. Results The mean age of patients was 35.02±6.82 years. The mean percentage of IgG positive plasma cells among tissue inflammatory cells was 6923±23.42 and the mean percentage of IgG4 positive plasma cells was 23.39±22.33. Among infiltrated plasma cells, 1.89% were positive for IgG4 and the ratio of IgG4 to IgG in plasma cells was 0.91. Based on the results of Pearson correlation test, a positive and significant correlation was found between the percentage of IgG4 and IgG in plasma cells (r=0.600, P=0.004). Conclusion A significant percentage of infiltrated plasma cells are IgG4 positive, which can play a role in the development of IGM. Therefore, further investigation and comparison with immunological mastitis is recommended.
背景与目的特发性肉芽肿性乳腺炎(IGM)是一种模仿癌症临床症状的慢性炎性病变。慢性肉芽肿性乳腺炎的另一种类型是免疫性乳腺炎,与IgG4浆细胞浸润有关。本研究旨在确定IGM样本中IgG4阳性浆细胞的状态。这是一项分析性横断面研究。采用人口普查方法,选取46例诊断为IGM的妇女进行研究。免疫组化法测定血浆细胞中IgG和IgG4的百分比。同时记录患者的年龄和手术类型。将数据输入SPSS软件,版本22,并使用统计检验进行分析。P<0.05认为差异有统计学意义。结果患者平均年龄35.02±6.82岁。IgG阳性浆细胞占组织炎性细胞的平均百分比为6923±23.42,IgG4阳性浆细胞占组织炎性细胞的平均百分比为23.39±22.33。浸润浆细胞中IgG4阳性率为1.89%,IgG4与IgG的比值为0.91。Pearson相关检验结果显示,血浆细胞中IgG4和IgG的百分比呈正相关且显著(r=0.600, P=0.004)。结论IgG4阳性的浸润浆细胞在IGM的发生发展中起重要作用。因此,建议进一步调查并与免疫性乳腺炎进行比较。
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引用次数: 0
The Effect of Moderate-intensity Continuous Exercise and Nanocurcumine Supplementation on STAT3 Gene Expression in Rats With Glioblastoma Multiforme Brain Tumor 中等强度持续运动和补充纳米莪术碱对多形性脑肿瘤大鼠STAT3基因表达的影响
Pub Date : 2022-11-01 DOI: 10.32598/jsmj.21.3.2793
S. Hajinajaf, H. Shirvani, Mehdi Roozbehani, A. Khademi
Background and Objectives Continuous exercise with moderate intensity and the use of nanocurcumin supplementation has the potential to control and reduce tumors of the central nervous system, including glioblastoma. We assessed the simultaneous effect of moderate-intensity continuous exercises and nanocurcumin supplementation on STAT3 gene expression in mice with glioblastoma multiforme brain tumors. Subjects and Methods Thirty-five male Wistar rats were randomly divided into seven groups of five rats: basal control (BC), 4-week control (4wC), basal cancer control (BT), 4-week cancer control (4 wT), cancer+training (TE), cancer+nanocurcumin (TN), cancer+ exercise + nanocurcumin (TEN). After injection of cancer cells in the forehead, the animals were treated with nanocurcumin by gavage at the dose of 80 mg/kg for 28 days, five days a week, and started moderate-intensity continuous training on the treadmill for four weeks, three days/weeks, 25 to 40 minutes per week at a speed of 18 m/min. Finally, and then rats were sacrificed and data were collected. Results Moderate-intensity continuous training with nanocurcumin supplementation significantly reduced tumor volume and STAT3 gene expression in the TEN group (P<0.05). But this decrease was not significant in the TE and TN groups. Conclusion It seems that with decreased STAT3 gene expression and brain tumor size, the combination of moderate-intensity continuous training and nanocurcumin supplementation has a therapeutic role in the treatment process of glioblastoma multiforme brain tumors.
背景和目的持续中等强度的运动和使用纳米姜黄素补充剂具有控制和减少中枢神经系统肿瘤的潜力,包括胶质母细胞瘤。我们评估了中等强度连续运动和补充纳米姜黄素同时对多形性脑肿瘤胶质母细胞瘤小鼠STAT3基因表达的影响。实验对象与方法35只雄性Wistar大鼠随机分为7组,每组5只:基础对照组(BC)、4周对照组(4wC)、基础癌对照组(BT)、4周癌对照组(4wt)、癌+训练(TE)、癌+纳米姜黄素(TN)、癌+运动+纳米姜黄素(TEN)。在前额注射癌细胞后,以纳米姜黄素80 mg/kg的剂量灌胃治疗,连续28天,每周5天,开始在跑步机上以18 m/min的速度进行4周,3天/周,每周25 ~ 40分钟的中等强度连续训练。最后处死大鼠,收集数据。结果中等强度持续训练加补充纳米姜黄素显著降低TEN组肿瘤体积和STAT3基因表达(P<0.05)。但在TE组和TN组中,这种下降并不明显。结论在多形性脑肿瘤胶质母细胞瘤的治疗过程中,中强度持续训练与补充纳米姜黄素相结合,随着STAT3基因表达和脑肿瘤大小的降低,似乎具有治疗作用。
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Jundishapur Journal of Medical Sciences
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