S. Bolukçu, S. Başaran, A. Çağatay, Halit Ozsut, H. Eraksoy
{"title":"Prospective Assessment of Blood Cultures Which Were Sent to the Clinical Microbiology Laboratory","authors":"S. Bolukçu, S. Başaran, A. Çağatay, Halit Ozsut, H. Eraksoy","doi":"10.5152/kd.2018.29","DOIUrl":"https://doi.org/10.5152/kd.2018.29","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77044454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The number of patients undergoing solid organ transplantation is increasing. Invasive fungal infection (IFI) is an important cause of graft loss and mortality in these patients. Invasive candidiasis is the most common IFI in solid organ transplant recipients. Because of lack of randomized controlled trials, antifungal treatments should be performed as recommended for other immunosuppressed hosts. Drug interactions should be considered when using azol groups. Klimik Dergisi 2019; 32(Suppl. 2): 174-6.
接受实体器官移植的病人越来越多。侵袭性真菌感染(IFI)是这些患者移植物丢失和死亡的重要原因。侵袭性念珠菌病是实体器官移植受者中最常见的IFI。由于缺乏随机对照试验，抗真菌治疗应像推荐的那样用于其他免疫抑制宿主。使用偶氮基团时应考虑药物相互作用。Klimik Dergisi 2019;32(5。2): 174 - 6。
{"title":"Treatment of Invasive Fungal Infections in Patients With Solid Organ Transplants","authors":"O. Kaya","doi":"10.5152/kd.2019.63","DOIUrl":"https://doi.org/10.5152/kd.2019.63","url":null,"abstract":"The number of patients undergoing solid organ transplantation is increasing. Invasive fungal infection (IFI) is an important cause of graft loss and mortality in these patients. Invasive candidiasis is the most common IFI in solid organ transplant recipients. Because of lack of randomized controlled trials, antifungal treatments should be performed as recommended for other immunosuppressed hosts. Drug interactions should be considered when using azol groups. Klimik Dergisi 2019; 32(Suppl. 2): 174-6.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83415127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Gunay, F. Akar, C. Gokbulut, S. Sakarya, Tip Fakultesi Tibbi Farmakoloji Anabilim Dali Balikesi Balikesir Universitesi
Objective: We aimed to investigate the dose and time course of tigecycline and vancomycin for effective intracellular concentration in bronchial epithelium of normal and cystic fibrosis lung. Methods: Differences between vancomycin and tigecycline in terms of their doseand time-dependent intracellular concentrations were determined with in vitro cell culture and the high performance liquid chromatography techniques. Results: The penetration of tigecycline was found significantly higher in cystic fibrosis cells compared to normal bronchial cells. The optimal dose for tigecycline was 30 μg/mL and the optimal time was 8 h in comparison to given dose and penetrating amount into the cells. Vancomycin dose needed to be given for minimal penetration into the cell was extremely higher than the minimum inhibitor concentration described in the guidelines. Conclusions: Penetration of tigecycline into cells of cystic fibrosis lung was found higher than normal lung cells, whereas cell penetration of vancomycin into both normal and cystic fibrosis cells was limited. These data suggest that tigecycline has a high therapeutic potential in lung infections of patients with cystic fibrosis. Klimik Dergisi 2018; 31(2): 139-43.
目的:探讨替加环素和万古霉素对正常肺和囊性纤维化肺支气管上皮细胞内有效浓度的影响。方法:采用体外细胞培养和高效液相色谱技术测定万古霉素和替加环素在剂量和时间依赖性细胞内浓度方面的差异。结果:囊性纤维化细胞中替加环素的穿透性明显高于正常支气管细胞。替加环素的最佳给药剂量为30 μg/mL，作用时间为8 h。为了使万古霉素渗透到细胞的最小程度，需要给予的万古霉素剂量远远高于指南中描述的最小抑制剂浓度。结论:替加环素对囊性纤维化肺细胞的渗透高于正常肺细胞，而万古霉素对正常肺细胞和囊性纤维化肺细胞的渗透均有限。这些数据表明，替加环素在囊性纤维化患者肺部感染中具有很高的治疗潜力。Klimik Dergisi 2018;31(2): 139 - 43。
{"title":"Determination of the Differences in Penetration of Tigecycline and Vancomycin Into Bronchial Epithelium of Normal and Cystic Fibrosis Lung","authors":"N. Gunay, F. Akar, C. Gokbulut, S. Sakarya, Tip Fakultesi Tibbi Farmakoloji Anabilim Dali Balikesi Balikesir Universitesi","doi":"10.5152/kd.2018.33","DOIUrl":"https://doi.org/10.5152/kd.2018.33","url":null,"abstract":"Objective: We aimed to investigate the dose and time course of tigecycline and vancomycin for effective intracellular concentration in bronchial epithelium of normal and cystic fibrosis lung. Methods: Differences between vancomycin and tigecycline in terms of their doseand time-dependent intracellular concentrations were determined with in vitro cell culture and the high performance liquid chromatography techniques. Results: The penetration of tigecycline was found significantly higher in cystic fibrosis cells compared to normal bronchial cells. The optimal dose for tigecycline was 30 μg/mL and the optimal time was 8 h in comparison to given dose and penetrating amount into the cells. Vancomycin dose needed to be given for minimal penetration into the cell was extremely higher than the minimum inhibitor concentration described in the guidelines. Conclusions: Penetration of tigecycline into cells of cystic fibrosis lung was found higher than normal lung cells, whereas cell penetration of vancomycin into both normal and cystic fibrosis cells was limited. These data suggest that tigecycline has a high therapeutic potential in lung infections of patients with cystic fibrosis. Klimik Dergisi 2018; 31(2): 139-43.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79672963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayşe Büyükdemirci, Esra Yüksekkaya, S. Cesur, Esra Kaya-Kılıç, C. Ataman-Hatipoglu, S. Kınıklı
{"title":"Encephalitis Following Herpes Zoster Ophthalmicus","authors":"Ayşe Büyükdemirci, Esra Yüksekkaya, S. Cesur, Esra Kaya-Kılıç, C. Ataman-Hatipoglu, S. Kınıklı","doi":"10.5152/kd.2018.37","DOIUrl":"https://doi.org/10.5152/kd.2018.37","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89674041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this report, three family members with cystic echinococcosis having multiple organ involvements were presented. As the first case, a 31-year-old male who had a childhood in a family raising animals sought medical advice with the complaint of side pain. His radiologic examination revealed cystic lesions in lungs and liver. Lesions in the lung were resected. “Puncture, aspiration, injection, respiration (PAIR)” treatment was applied to lesions in the liver. The second case was the brother of the first one, a 36-year-old male. Cystic lesions in lungs, liver and spleen were detected on his radiologic imaging. Lesions in lungs were resected and PAIR treatment was applied to hepatic and splenic lesions. The last case was the 56-year-old mother. Her radiologic examination revealed cystic lesions in left lung and liver. Pulmonary lesion was resected and PAIR treatment was applied to lesions in the liver. All patients were followed up under albendazole treatment. In conclusion, family scanning is an important issue, especially in socioeconomically developing, endemic areas where farming is common. Klimik Dergisi 2018; 31(2): 165-8.
在这个报告中，三个患有囊性包虫病的家庭成员有多器官受累。作为第一例病例，一名31岁男性，童年生活在一个饲养动物的家庭，以侧痛为主诉求医。他的放射检查显示肺和肝脏有囊性病变。切除肺内病变。肝内病变采用穿刺、抽吸、注射、呼吸(PAIR)治疗。第二个病例是第一个病例的兄弟，一名36岁男性。影像学检查发现肺、肝、脾有囊性病变。切除肺部病变，对肝、脾病变行PAIR治疗。最后一个病例是56岁的母亲。放射学检查显示左肺和肝有囊性病变。切除肺部病变，对肝脏病变进行PAIR治疗。所有患者均在阿苯达唑治疗下随访。总之，家庭扫描是一个重要的问题，特别是在社会经济发展中、农业普遍存在的流行地区。Klimik Dergisi 2018;31(2): 165 - 8。
{"title":"Cystic Echinococcosis: Importance of Family Screening","authors":"B. Hekimoglu, Y. Akkas, B. Kocer","doi":"10.5152/kd.2018.39","DOIUrl":"https://doi.org/10.5152/kd.2018.39","url":null,"abstract":"In this report, three family members with cystic echinococcosis having multiple organ involvements were presented. As the first case, a 31-year-old male who had a childhood in a family raising animals sought medical advice with the complaint of side pain. His radiologic examination revealed cystic lesions in lungs and liver. Lesions in the lung were resected. “Puncture, aspiration, injection, respiration (PAIR)” treatment was applied to lesions in the liver. The second case was the brother of the first one, a 36-year-old male. Cystic lesions in lungs, liver and spleen were detected on his radiologic imaging. Lesions in lungs were resected and PAIR treatment was applied to hepatic and splenic lesions. The last case was the 56-year-old mother. Her radiologic examination revealed cystic lesions in left lung and liver. Pulmonary lesion was resected and PAIR treatment was applied to lesions in the liver. All patients were followed up under albendazole treatment. In conclusion, family scanning is an important issue, especially in socioeconomically developing, endemic areas where farming is common. Klimik Dergisi 2018; 31(2): 165-8.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73759684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bahar Akgun-Karapinar, M. Yilmaz, Melike Omeroglu, Esma Erbudak, Afet Akdag-Kose, Derya Aydın
Objective: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have been increasingly reported in recent years, and they commonly cause skin and skin-related structure infections. The aim of this study was to investigate CA-MRSA frequency and nasal carriage in patients with pyoderma. Methods: Between November 2011 and August 2013, we aimed to investigate the frequency of MRSA isolated from nasal swab and wound specimens of 38 patients with pyoderma according to the “community-acquired infection" criteria of Centers for Disease Control and Prevention. Also, the criteria investigated included age, gender, number of people residing in the same household and their hospitalization frequency, chronic illnesses, and antibiotic use in the previous six months. The control group of 103 patients who were evaluated with the same criteria and with various skin diseases excluding pyoderma were examined by culturing their nasal swabs. Results: Totally, 38 specimens obtained from patients with folliculitis (n=18), furuncle (n=7), cellulitis (n=4), abscess (n=2), hidradenitis suppurativa (n=2), carbuncle (n=1), and impetigo (n=4) were investigated, and 2 (5.3%) CA-MRSA were isolated. One of these strains were isolated from a patient with folliculitis, and the other strain was isolated from nasal swab of the another patient of whose sample from folliculitis was negative for CA-MRSA. One (1%) CA-MRSA strain was isolated from the Özet Amaç: Son yıllarda, toplumdan kazanılmış metisiline dirençli Staphylococcus aureus (TK-MRSA) infeksiyonlarının giderek yaygınlaştığı ve bu bakterilerin en sık olarak deri ve deriyle ilişkili yapıların infeksiyonlarına neden olduğu bildirilmektedir. Çalışmamızda pyodermili hastalarda TK-MRSA sıklığının ve burun taşıyıcılığının belirlenmesi amaçlanmıştır. Yöntemler: Çalışmamızda, Kasım 2011-Ağustos 2013 tarihleri arasında, Centers for Disease Control and Prevention’ın “toplumdan kazanılmış infeksiyon” kriterlerine uyan 38 hastadan alınan deri lezyonu ve burun sürüntüsü örnekleri değerlendirilmiştir. Ayrıca hastalar, yaş, cinsiyet, evde yaşayan kişi sayısı, evde sık hastaneye yatış öyküsü olan birey olması, kronik hastalıklar, son altı aydır antibiyotik kullanımı ve poliklinik başvurusu gibi demografik özelliklerle diğer sağlık bakımıyla ilişkili risk faktörleri açısından da incelenmiştir. Kontrol grubu yukarıdaki kriterlere uyan ve pyodermi dışı deri hastalıkları olan 103 hastadan oluşturularak burun sürüntü örnekleri değerlendirilmiştir. Bulgular: Hasta grubunda folikülit (n=18), furonkül (n=7), selülit (n=4), apse (n=2), hidradenitis suppurativa (n=2), karbonkül (n=1) ve impetigo (n=4) olmak üzere toplam 38 hastadan alınan sürüntü örnekleri değerlendirilmiş ve 2 (%5.3) TK-MRSA izole edilmiştir. Bunlardan biri folikülitli hastanın lezyonundan izole edilmiş, diğeri ise farklı bir folikülitli hastanın lezyonunda saptanmamasına karşın aynı hastanın burun sürüntüsünden izole edilmiştir. Kontrol grubundan alın
目的:社区获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)感染近年来越来越多的报道，它们通常引起皮肤和皮肤相关结构感染。本研究的目的是调查脓皮病患者CA-MRSA的频率和鼻腔携带情况。方法:根据美国疾病控制与预防中心的“社区获得性感染”标准，对2011年11月至2013年8月38例脓皮病患者鼻拭子和伤口标本中MRSA的分离频率进行调查。此外，调查的标准还包括年龄、性别、居住在同一家庭的人数及其住院频率、慢性病和过去6个月的抗生素使用情况。对照组103名患者采用相同的标准进行评估，并患有除脓皮病外的各种皮肤病，通过培养鼻拭子进行检查。结果:共采集毛囊炎(18例)、疖(7例)、蜂窝组织炎(4例)、脓肿(2例)、化脓性汗腺炎(2例)、痈(1例)、脓疱疮(4例)患者标本38例，分离CA-MRSA 2例(5.3%)。其中一株是从一名毛囊炎患者中分离出来的，另一株是从另一名毛囊炎患者的鼻拭子中分离出来的，该患者的CA-MRSA样本呈阴性。从Özet Amaç: Son yıllarda, toplumdan kazanılmış metisiline direnli金黄色葡萄球菌(TK-MRSA) infeksiyonlarının giderek yaygınlaştığı ve bu bakterilerin en sık olarak deri ve derile ili kili yapıların infeksiyonlarına neden olduğu bildirilmektedir中分离出1株(1%)CA-MRSA菌株。Çalışmamızda pyodermili hastalarda TK-MRSA sıklığının ve burn taşıyıcılığının belirlenmesi amaçlanmıştır。Yöntemler: Çalışmamızda, Kasım 2011-Ağustos 2013 tarihleri arasında，疾病预防控制中心' ın " toplumdan kazanılmış infeksiyon " kriterlerine uyan 38 hasadan alınan deri lezyonu ve burun sürüntüsü örnekleri değerlendirilmiştir。埃尔ıca hastalar,丫ş、cinsiyet evde丫ş·kiş我说ı年代ıevde年代kıhastaneye雅特ışoykusu olan birey olması,kronik hastalıklar)儿子altıaydır antibiyotik kullanımıve poliklinik英航şvurusu gibi demografik ozelliklerle diğer sağl kı贝克ımıyla伊犁ş基利风险faktorleri acı年代ından da incelenmiş行动。控制组yukarıdaki kriterlere uyan ve pyodermi dışı deri hastalıkları olan 103 hastadan olu turularak燃烧sürüntü örnekleri değerlendirilmiştir。疱疹:Hasta grubunda folik lit (n=18)， furonk l (n=7)， selillit (n=4)， apse (n=2)，化脓性hidradenitis (n=2)， karbonk l (n=1)，脓疱疮(n=4) olmak zere toplam 38 hasadan alınan sürüntü örnekleri değerlendirilmiş ve 2 (%5.3) TK-MRSA izole edilmi tir。Bunlardan biri folik litli hastanın lezyonundan izole edilmiir, diğeri ise farklyi bir folik litli hastanın lezyonunda saptanmamasına karşın aynyi hastanın burun s rnnt s nden izole edilmiir。控制grubundan alınan烧伤sürüntü örneklerinÖzgün Araştırma /原创文章
{"title":"Determination of Frequency and Nasal Carriage of Community-Acquired Methicillin-Resistant Staphylococcus aureus in Patients with Pyoderma","authors":"Bahar Akgun-Karapinar, M. Yilmaz, Melike Omeroglu, Esma Erbudak, Afet Akdag-Kose, Derya Aydın","doi":"10.5152/kd.2018.28","DOIUrl":"https://doi.org/10.5152/kd.2018.28","url":null,"abstract":"Objective: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have been increasingly reported in recent years, and they commonly cause skin and skin-related structure infections. The aim of this study was to investigate CA-MRSA frequency and nasal carriage in patients with pyoderma. Methods: Between November 2011 and August 2013, we aimed to investigate the frequency of MRSA isolated from nasal swab and wound specimens of 38 patients with pyoderma according to the “community-acquired infection\" criteria of Centers for Disease Control and Prevention. Also, the criteria investigated included age, gender, number of people residing in the same household and their hospitalization frequency, chronic illnesses, and antibiotic use in the previous six months. The control group of 103 patients who were evaluated with the same criteria and with various skin diseases excluding pyoderma were examined by culturing their nasal swabs. Results: Totally, 38 specimens obtained from patients with folliculitis (n=18), furuncle (n=7), cellulitis (n=4), abscess (n=2), hidradenitis suppurativa (n=2), carbuncle (n=1), and impetigo (n=4) were investigated, and 2 (5.3%) CA-MRSA were isolated. One of these strains were isolated from a patient with folliculitis, and the other strain was isolated from nasal swab of the another patient of whose sample from folliculitis was negative for CA-MRSA. One (1%) CA-MRSA strain was isolated from the Özet Amaç: Son yıllarda, toplumdan kazanılmış metisiline dirençli Staphylococcus aureus (TK-MRSA) infeksiyonlarının giderek yaygınlaştığı ve bu bakterilerin en sık olarak deri ve deriyle ilişkili yapıların infeksiyonlarına neden olduğu bildirilmektedir. Çalışmamızda pyodermili hastalarda TK-MRSA sıklığının ve burun taşıyıcılığının belirlenmesi amaçlanmıştır. Yöntemler: Çalışmamızda, Kasım 2011-Ağustos 2013 tarihleri arasında, Centers for Disease Control and Prevention’ın “toplumdan kazanılmış infeksiyon” kriterlerine uyan 38 hastadan alınan deri lezyonu ve burun sürüntüsü örnekleri değerlendirilmiştir. Ayrıca hastalar, yaş, cinsiyet, evde yaşayan kişi sayısı, evde sık hastaneye yatış öyküsü olan birey olması, kronik hastalıklar, son altı aydır antibiyotik kullanımı ve poliklinik başvurusu gibi demografik özelliklerle diğer sağlık bakımıyla ilişkili risk faktörleri açısından da incelenmiştir. Kontrol grubu yukarıdaki kriterlere uyan ve pyodermi dışı deri hastalıkları olan 103 hastadan oluşturularak burun sürüntü örnekleri değerlendirilmiştir. Bulgular: Hasta grubunda folikülit (n=18), furonkül (n=7), selülit (n=4), apse (n=2), hidradenitis suppurativa (n=2), karbonkül (n=1) ve impetigo (n=4) olmak üzere toplam 38 hastadan alınan sürüntü örnekleri değerlendirilmiş ve 2 (%5.3) TK-MRSA izole edilmiştir. Bunlardan biri folikülitli hastanın lezyonundan izole edilmiş, diğeri ise farklı bir folikülitli hastanın lezyonunda saptanmamasına karşın aynı hastanın burun sürüntüsünden izole edilmiştir. Kontrol grubundan alın","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85183794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Şahin, A. Şahin, A. Gunduz, Ayse Aktemur, Nuray Kes-Uzun
{"title":"HIV Seropositivity in a Penal Institution in Turkey: A Cross-Sectional Study","authors":"A. Şahin, A. Şahin, A. Gunduz, Ayse Aktemur, Nuray Kes-Uzun","doi":"10.5152/kd.2018.31","DOIUrl":"https://doi.org/10.5152/kd.2018.31","url":null,"abstract":"","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88439670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nazmiye Ulku Tuzemen, Reside Borce Hemis, M. Yiğit, Mahmut Kapsiz, Kadir Efe, Tekin Tuncel, Y. Heper, S. Gullulu, C. Ozakin, Tibbi Mikrobiyoloji Laboratuvari Bursa Turkiye Bursa Dortcelik Cocuk Hastaliklari Hastanesi
A 25-year-old female with no remarkable medical or family history presented with sudden chest pain and shortness of breath. Transesophageal echocardiography revealed a defect in intraventricular septum, and a loose mass image was observed on the septal cuspis of tricuspid valve. A total of 6 blood cultures were taken, one bottle of blood culture from each arm of the patient for three consecutive days. All bottles yielded growth of Neisseria animaloris. All isolates were identified by PhoenixTM 100 (Becton Dickinson, Diagnostic Instrument System, Sparks, MD, USA), and the identification was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) (Bruker Daltonik, Bremen, Germany). Antibiotic susceptibility results were studied by gradient diffusion method, and interpreted as resistant to penicillin G and susceptible to ceftriaxone by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2013 standards for N. meningitidis. No risk factor such as animal contact or bite, and tooth or gum problems was detected in the patient evaluation because of the feature of the causative agent. Definitive infective endocarditis was diagnosed according to modified Duke criteria because of fever, infective endocarditis-prone cardiac condition and pulmonary embolism, vegetation in echocardiography and growth in consecutive blood cultures. Although there are some reports that N. animaloris causes wound infections in the cases bitten by a dog or a cat, there is no information about it as a causative agent for infective endocarditis. Our case is the only case of infective endocarditis that is caused by N. animaloris. Klimik Dergisi 2018; 31(2): 161-4.
{"title":"First Case of Infective Endocarditis Associated With Neisseria animaloris","authors":"Nazmiye Ulku Tuzemen, Reside Borce Hemis, M. Yiğit, Mahmut Kapsiz, Kadir Efe, Tekin Tuncel, Y. Heper, S. Gullulu, C. Ozakin, Tibbi Mikrobiyoloji Laboratuvari Bursa Turkiye Bursa Dortcelik Cocuk Hastaliklari Hastanesi","doi":"10.5152/kd.2018.38","DOIUrl":"https://doi.org/10.5152/kd.2018.38","url":null,"abstract":"A 25-year-old female with no remarkable medical or family history presented with sudden chest pain and shortness of breath. Transesophageal echocardiography revealed a defect in intraventricular septum, and a loose mass image was observed on the septal cuspis of tricuspid valve. A total of 6 blood cultures were taken, one bottle of blood culture from each arm of the patient for three consecutive days. All bottles yielded growth of Neisseria animaloris. All isolates were identified by PhoenixTM 100 (Becton Dickinson, Diagnostic Instrument System, Sparks, MD, USA), and the identification was confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) (Bruker Daltonik, Bremen, Germany). Antibiotic susceptibility results were studied by gradient diffusion method, and interpreted as resistant to penicillin G and susceptible to ceftriaxone by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2013 standards for N. meningitidis. No risk factor such as animal contact or bite, and tooth or gum problems was detected in the patient evaluation because of the feature of the causative agent. Definitive infective endocarditis was diagnosed according to modified Duke criteria because of fever, infective endocarditis-prone cardiac condition and pulmonary embolism, vegetation in echocardiography and growth in consecutive blood cultures. Although there are some reports that N. animaloris causes wound infections in the cases bitten by a dog or a cat, there is no information about it as a causative agent for infective endocarditis. Our case is the only case of infective endocarditis that is caused by N. animaloris. Klimik Dergisi 2018; 31(2): 161-4.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87342708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Candida infection is a serious problem associated with increased morbidity and mortality in intensive care unit (ICU). Multiple risk factors and severe diseases make patients vulnerable to fungal infections in ICUs. Diagnosis of Candida infections should be established rapidly in order to initiate the efficient treatment early. Diagnosis of Candida infections is a very challenging process for clinicians due to comorbidities and complex clinical conditions in the critically ill patients. Growth of the agent in blood, sterile body fluid and tissue cultures or histopathological diagnosis are the main methods for the diagnosis. The biomarkers for fungal agents and various risk factors of the patient are also used for diagnostic purposes with clinical evaluation. Klimik Dergisi 2019; 32(Suppl. 2): 135-9.
念珠菌感染是重症监护病房(ICU)发病率和死亡率增加的一个严重问题。多重危险因素和严重疾病使icu患者容易发生真菌感染。念珠菌感染的诊断应迅速确立，以便尽早开始有效的治疗。由于危重患者的合并症和复杂的临床条件，诊断念珠菌感染对临床医生来说是一个非常具有挑战性的过程。血液、无菌体液、组织培养或组织病理学诊断是诊断的主要方法。真菌制剂的生物标志物和患者的各种危险因素也用于诊断目的和临床评估。Klimik Dergisi 2019;32(5。2): 135 - 9。
{"title":"Candida Infections in Intensive Care Unit Patients: How to Diagnose?","authors":"B. Bilgili","doi":"10.5152/kd.2019.57","DOIUrl":"https://doi.org/10.5152/kd.2019.57","url":null,"abstract":"Candida infection is a serious problem associated with increased morbidity and mortality in intensive care unit (ICU). Multiple risk factors and severe diseases make patients vulnerable to fungal infections in ICUs. Diagnosis of Candida infections should be established rapidly in order to initiate the efficient treatment early. Diagnosis of Candida infections is a very challenging process for clinicians due to comorbidities and complex clinical conditions in the critically ill patients. Growth of the agent in blood, sterile body fluid and tissue cultures or histopathological diagnosis are the main methods for the diagnosis. The biomarkers for fungal agents and various risk factors of the patient are also used for diagnostic purposes with clinical evaluation. Klimik Dergisi 2019; 32(Suppl. 2): 135-9.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77741486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In this study, we evaluated whether HBV serology had been investigated before chemotherapy or not, and whether antiviral prophylaxis had been given or not to hepatitis B surface antigen (HBsAg)and/or hepatitis B core antibody (antiHBc IgG)-positive patients. Methods: The study was planned retrospectively between May 2012 and April 2014. Patients who were followed in the oncology outpatient clinic and whose chemotherapy was initiated due to solid organ malignancy were included. IBM SPSS Statistics for Windows. Version 22.0 (Statistical Package for the Social Sciences, IBM Corp., Armonk, NY, USA) program was used for statistical evaluation. Results: As a result of the study, the data of 1476 regular follow-up patients were reached. 49.4% of the patients were male. The mean age was calculated as 60.6±13.3. Of the patients, 864 (58.1%) were screened for HBV infection. For screening, HBsAg and anti-HBs were used together in 53.8% of the patients, and only HBsAg was used in 4.3% of them. Anti-HBc IgG was not used in any of the patients. HBsAg positivity was 3.5% and antiHBs positivity was 37.9% of the screened patients. Of HBsAgpositive patients, 74.1% was started prophylactic antivirals (entecavir in 2 patients, lamivudine in 21 patients), whereas eight patients did not receive prophylaxis. Conclusions: It was determined that HBV serology was investigated in most of the patients who would receive chemotherapy but the serologic parameters used for investigation were not suitable in most cases. Further studies are needed to increase awareness on this issue. Klimik Dergisi 2018; 31(2): 101-5.
目的:在本研究中，我们评估化疗前是否进行HBV血清学检查，以及乙肝表面抗原(HBsAg)和/或乙肝核心抗体(抗hbc IgG)阳性患者是否给予抗病毒预防治疗。方法:研究计划于2012年5月至2014年4月进行回顾性研究。在肿瘤门诊接受随访并因实体器官恶性肿瘤而开始化疗的患者包括在内。IBM SPSS Statistics for Windows。使用Version 22.0 (Statistical Package for the Social Sciences, IBM Corp.， Armonk, NY, USA)程序进行统计评估。结果:本研究共获得1476例定期随访患者的资料。男性占49.4%。平均年龄为60.6±13.3岁。864例(58.1%)患者接受了HBV感染筛查。筛查时，53.8%的患者同时使用HBsAg和anti-HBs, 4.3%的患者仅使用HBsAg。所有患者均未使用抗- hbc IgG。筛查患者HBsAg阳性率为3.5%，抗hbbs阳性率为37.9%。在hbsag阳性患者中，74.1%开始使用预防性抗病毒药物(2例恩替卡韦，21例拉米夫定)，而8例患者未接受预防治疗。结论:大多数接受化疗的患者进行了HBV血清学调查，但大多数病例的血清学参数不合适。需要进一步研究以提高对这一问题的认识。Klimik Dergisi 2018;31(2): 101 - 5。
{"title":"Investigation of Hepatitis B Serology in Oncological Patients Receiving Chemotherapy","authors":"Emine Turkoglu, M. Uysal, N. Demirturk","doi":"10.5152/kd.2018.25","DOIUrl":"https://doi.org/10.5152/kd.2018.25","url":null,"abstract":"Objective: In this study, we evaluated whether HBV serology had been investigated before chemotherapy or not, and whether antiviral prophylaxis had been given or not to hepatitis B surface antigen (HBsAg)and/or hepatitis B core antibody (antiHBc IgG)-positive patients. Methods: The study was planned retrospectively between May 2012 and April 2014. Patients who were followed in the oncology outpatient clinic and whose chemotherapy was initiated due to solid organ malignancy were included. IBM SPSS Statistics for Windows. Version 22.0 (Statistical Package for the Social Sciences, IBM Corp., Armonk, NY, USA) program was used for statistical evaluation. Results: As a result of the study, the data of 1476 regular follow-up patients were reached. 49.4% of the patients were male. The mean age was calculated as 60.6±13.3. Of the patients, 864 (58.1%) were screened for HBV infection. For screening, HBsAg and anti-HBs were used together in 53.8% of the patients, and only HBsAg was used in 4.3% of them. Anti-HBc IgG was not used in any of the patients. HBsAg positivity was 3.5% and antiHBs positivity was 37.9% of the screened patients. Of HBsAgpositive patients, 74.1% was started prophylactic antivirals (entecavir in 2 patients, lamivudine in 21 patients), whereas eight patients did not receive prophylaxis. Conclusions: It was determined that HBV serology was investigated in most of the patients who would receive chemotherapy but the serologic parameters used for investigation were not suitable in most cases. Further studies are needed to increase awareness on this issue. Klimik Dergisi 2018; 31(2): 101-5.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83931619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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