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Clinical and Radiological Characteristics of Central Compartment Atopic Disease in Korea 韩国中央区特应性疾病的临床和放射学特征
Q4 Medicine Pub Date : 2023-11-21 DOI: 10.3342/kjorl-hns.2023.00766
Hwaejoon Jung, Su-Jong Kim, Jee Won Moon, Jae Hoon Cho, Yong-Dae Kim, Heung-Man Lee
Background and Objectives Central compartment atopic disease (CCAD) has been studied with increasingly more importance as a distinct subtype of chronic rhinosinusitis with nasal polyp (CRSwNP). Studies have shown that CCAD in Western populations show a strong association with allergy and typical features of medial nasal structure and sinus involvement. The purpose of this study was to evaluate the clinical characteristics of CCAD and compare them to those of other subtypes of CRS in Korea.Subjects and Method A chart review was performed retrospectively at two tertiary rhinologic centers for patients who were treated with bilateral endoscopic sinus surgery for CRS with or without nasal polyp from January 2019 to December 2021. Patients were divided into three groups, namely CCAD, CRSwNP, and CRS without nasal polyps (CRSsNP), and demographics, clinical characteristics, and imaging data were compared among the three groups.Results A total of 150 patients were included in this study (50 patients in each group). CCAD showed similar nasal symptoms with CRSwNP, but higher rates of olfactory impairment than CRSsNP did. Allergy prevalence, serum total immunoglobulin E, and serum eosinophil were significantly higher in CCAD than in CRSwNP or CRSsNP. In CT scans of paranasal sinuses, CCAD showed significantly less haziness of maxillary sinus and higher ethmoid/maxillary score ratio than the other two groups. In addition, CT scans showed mucosal involvements of central compartment in CCAD.Conclusion CCAD has characteristic endoscopic and imaging findings, showing a high prevalence of allergy and a strong association with the markers of type 2 inflammation. Therefore, CCAD is a distinct disease of CRSwNP and its allergic etiology should be considered in the management of patients with CCAD phenotype.
背景和目的 中央隔室特应性疾病(CCAD)作为伴有鼻息肉的慢性鼻窦炎(CRSwNP)的一个独特亚型,其重要性日益凸显。研究表明,西方人群中的 CCAD 与过敏症以及鼻腔内侧结构和鼻窦受累的典型特征密切相关。本研究旨在评估CCAD的临床特征,并将其与韩国其他亚型CRS的临床特征进行比较。研究对象和方法 在两家三级鼻科中心对2019年1月至2021年12月期间因伴有或不伴有鼻息肉的CRS而接受双侧内窥镜鼻窦手术治疗的患者进行了病历回顾。患者被分为三组,即CCAD、CRSwNP和无鼻息肉CRS(CRSsNP),并对三组患者的人口统计学、临床特征和影像学数据进行了比较。CCAD与CRSwNP表现出相似的鼻部症状,但嗅觉障碍的发生率高于CRSsNP。CCAD 的过敏症发病率、血清总免疫球蛋白 E 和血清嗜酸性粒细胞均显著高于 CRSwNP 或 CRSsNP。在鼻旁窦 CT 扫描中,CCAD 的上颌窦模糊度和乙状窦/上颌窦评分比明显低于其他两组。结论 CCAD 具有特征性的内窥镜和影像学检查结果,显示出过敏性疾病的高发病率以及与 2 型炎症标志物的密切联系。因此,CCAD 是 CRSwNP 的一种独特疾病,在治疗 CCAD 表型患者时应考虑其过敏病因。
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引用次数: 0
The Role of Catecholamines (Epinephrine/Norepinephrine) and Beta Blocker in Head and Neck Cancer 儿茶酚胺(肾上腺素/去甲肾上腺素)和β受体阻滞剂在头颈癌中的作用
Q4 Medicine Pub Date : 2023-11-21 DOI: 10.3342/kjorl-hns.2023.00570
Min-Su Kim
Beta blockers are used for various indications, particularly cardiac arrhythmias, cardioprotection after myocardial infarction, hypertension, migraine, tremor, and anxiety disorders, by inhibiting the sympathetic actions of catecholamine hormones (i.e., epinephrine and norepinephrine). This sympathetic mechanism occurs via beta-adrenergic receptors. Recently, experimental evidence showed that malignant cell lines express beta-adrenergic receptors and that sympathomimetic neurotransmitters may affect carcinogenesis through these receptors. These neurotransmitters are suggested to have a major impact on secondary tumor growth and to contribute to metastasis, induction of angiogenesis, and tissue invasion. Given that beta-blockers are considered safe, cheap, and effective, the potential beneficial effects of their use for cancer would be of interest. However, evidence from epidemiological and clinical studies has been inconclusive. Especially the effect of beta-blockers on head and neck cancer has rarely been investigated.
β受体阻滞剂通过抑制儿茶酚胺激素(即肾上腺素和去甲肾上腺素)的交感作用,可用于各种适应症,尤其是心律失常、心肌梗死后的心脏保护、高血压、偏头痛、震颤和焦虑症。这种交感机制是通过β-肾上腺素能受体实现的。最近,有实验证据表明,恶性细胞株表达 beta 肾上腺素能受体,拟交感神经递质可能通过这些受体影响致癌作用。这些神经递质被认为对肿瘤的继发性生长有重大影响,并有助于肿瘤转移、诱导血管生成和组织侵袭。鉴于β-受体阻滞剂被认为是安全、廉价和有效的,因此使用这种药物治疗癌症的潜在益处值得关注。然而,来自流行病学和临床研究的证据尚无定论。尤其是关于β-受体阻滞剂对头颈部癌症的影响的研究更是少之又少。
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引用次数: 0
Prediction of Voice Outcomes After Hemithyroidectomy Using Skin Electrode Intraoperative Neuromonitoring 利用皮肤电极术中神经监测仪预测甲状旁腺半切除术后的嗓音效果
Q4 Medicine Pub Date : 2023-11-21 DOI: 10.3342/kjorl-hns.2023.00941
Dabin Lee, Hyeon Geun Kim, Minsu Kwon, Jae-Gu Cho, K. Oh, S. Baek, Soon Young Kwon, J. Woo, K. Jung
Background and Objectives This study focused on predicting voice outcomes following hemithyroidectomy using skin electrode intraoperative neuromonitoring (IONM).Subjects and Method The study involved 82 patients who underwent hemithyroidectomy. During the surgery, the researchers recorded skin IONM values for the vagus nerve and recurrent laryngeal nerve. Voice quality evaluations were conducted before the surgery and at various intervals after the surgery (one week, one month, three months, six months, and one year) using the multidimensional voice program (MDVP), voice handicap index (VHI), and the grade, roughness, breathiness, asthenia, strain (GRBAS) scale. The study aimed to correlate perioperative skin IONM values with subjective and objective voice outcomes.Results The VHI scores increased up to three months post-surgery, with statistically significant changes observed at one week post-surgery. The GRBAS scale scores also increased significantly at one month post-surgery. Similar trends were observed in the MDVP data, including a decrease in the maximum pitch between one week and three months post-surgery. Additionally, the study found that lower delta-V values (difference between the preoperative and postoperative signal amplitude of vagus nerve stimulation) were associated with higher F0 values at one week and three months post-surgery, while jitter and noise-to-harmonic ratio were higher in the group with higher delta-V values at three months post-surgery.Conclusion Greater differences between the preoperative and postoperative signal amplitude of vagus nerve stimulation during surgery were linked to worse postoperative voice outcomes. Voice parameters worsened for up to 3 months after hemithyroidectomy but showed signs of recovery afterwards. These findings offer insights into predicting and managing voice outcomes after hemithyroidectomy.
背景和目的 本研究的重点是利用皮肤电极术中神经监测(IONM)预测半喉切除术后的嗓音效果。在手术过程中,研究人员记录了迷走神经和喉返神经的皮肤 IONM 值。在手术前和手术后的不同时间段(一周、一个月、三个月、六个月和一年),研究人员使用多维嗓音程序(MDVP)、嗓音障碍指数(VHI)和等级、粗糙度、呼吸感、气喘、劳损(GRBAS)量表对嗓音质量进行了评估。研究旨在将围术期皮肤 IONM 值与主观和客观嗓音结果联系起来。结果 VHI 分值在术后三个月内有所增加,术后一周内观察到显著的统计学变化。GRBAS 量表评分在术后一个月也有明显增加。在 MDVP 数据中也观察到了类似的趋势,包括术后一周到三个月期间最大音调的降低。此外,研究还发现,术后一周和三个月时,较低的 delta-V 值(术前和术后迷走神经刺激信号振幅之间的差异)与较高的 F0 值相关,而术后三个月时,delta-V 值较高组别中的抖动和噪音-谐波比更高。嗓音参数在半结节甲状腺切除术后三个月内恶化,但之后有恢复迹象。这些发现为预测和管理半乳甲状腺切除术后的嗓音效果提供了启示。
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引用次数: 0
Hybrid Retroauricular Approach Without Ear Canal Skin Incision 无耳道皮肤切口的复合耳后入路
Q4 Medicine Pub Date : 2023-10-21 DOI: 10.3342/kjorl-hns.2023.00780
Soon Joon Kim, Joong Keun Kwon
The majority of tympanoplasty procedures have been performed using the retroauricular approach to improve visualisation of the anterior tympanic membrane. The classic retroauricular approach requires elevation of the Körner flap and tympano-meatal flap through the ear canal skin incision. This step can lead to the exposure of the bones in the ear canal, resulting in delayed wound healing and pain, especially in elderly or immunocompromised patients. Endoscopic ear surgery is a minimally invasive procedure that offers a wider field of view, but has the disadvantage of being a one-handed operation and cannot avoid skin incisions in the ear canal for tympanoplasty. Here we present a hybrid retroauricular approach without skin incision of the ear canal, using both microscope and endoscope. This method provides very fast wound healing and significantly less pain.
大多数鼓室成形术采用耳后入路来改善鼓室前膜的显像。经典的耳后入路需要通过耳道皮肤切口抬高Körner皮瓣和鼓室-金属皮瓣。这一步骤可能导致耳道内的骨骼暴露,导致伤口愈合延迟和疼痛,特别是在老年人或免疫功能低下的患者中。内窥镜耳部手术是一种微创手术,提供了更广阔的视野,但缺点是单手手术,不能避免耳道皮肤切口进行鼓室成形术。在这里,我们提出了一种混合的耳后入路,没有皮肤切口的耳道,使用显微镜和内窥镜。这种方法提供了非常快的伤口愈合和显着减少疼痛。
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引用次数: 0
Tinnitus and Cognitive Decline 耳鸣和认知能力下降
Q4 Medicine Pub Date : 2023-10-21 DOI: 10.3342/kjorl-hns.2023.00913
Hyun-Jin Lee, Ye Ji Shim, Munyoung Chang
Tinnitus, defined as the perception of sound in the absence of any external stimuli, is a condition which affects a significant number of people worldwide. Although the pathophysiology of tinnitus is not fully understood, hearing loss is known to be a major contributor. To date, many studies have investigated the relationship between hearing loss and cognitive function, and hearing loss is now considered a modifiable risk factor for cognitive decline. In this context, recent studies have investigated whether tinnitus, which is closely associated with hearing loss, is also a risk factor for cognitive decline. However, conflicting results have been reported regarding the relationship between these two conditions. Several studies have reported cognitive decline in tinnitus patients, particularly in areas related to working memory and attention. The consideration of patient age is crucial, as older people seem to be more affected by tinnitus-related cognitive issues. In contrast, some studies have indicated no direct association between tinnitus and cognitive decline, with some even indicating potential cognitive improvement in tinnitus patients. In this article, we review the current research on the relationship between tinnitus and cognitive function and discuss the potential association between these two conditions.
耳鸣被定义为在没有任何外部刺激的情况下对声音的感知,是一种影响世界上很多人的疾病。虽然耳鸣的病理生理机制尚不完全清楚,但听力损失是耳鸣的主要原因。迄今为止,许多研究已经调查了听力损失和认知功能之间的关系,听力损失现在被认为是认知能力下降的一个可改变的危险因素。在此背景下,最近的研究调查了耳鸣是否也是认知能力下降的危险因素,耳鸣与听力损失密切相关。然而,关于这两种情况之间的关系,报道了相互矛盾的结果。一些研究报告耳鸣患者的认知能力下降,特别是在与工作记忆和注意力相关的领域。考虑患者的年龄是至关重要的,因为老年人似乎更容易受到耳鸣相关认知问题的影响。相比之下,一些研究表明耳鸣与认知能力下降之间没有直接联系,甚至有一些研究表明耳鸣患者的认知能力可能得到改善。本文就耳鸣与认知功能关系的研究现状进行综述,并就耳鸣与认知功能之间的潜在联系进行探讨。
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引用次数: 0
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Q4 Medicine Pub Date : 2023-09-27 DOI: 10.3342/kjorl-hns.2023.00430
Younghoon Cho, Young Chul Kim, Jiyoung Lee, Seung Ha Oh, Sang-Yeon Lee, Jun Ho Lee, Moo Kyun Park, Myung-Whan Suh
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引用次数: 0
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Q4 Medicine Pub Date : 2023-09-25 DOI: 10.3342/kjorl-hns.2023.00066
Byung Guk Kim
The olfaction is not a degraded sense, but it plays an important function not only in survival but also in human senses, emotions, memories, and social functions. It is a complex and difficult characteristic of the olfaction that has only recently been scientific development. Although interest has increased recently, the characteristics and functions of human olfactory function are not well known, and medical research are also focused on disease. In fact, interest in medical aspects such as the cause of olfactory diseases, olfactory function tests, treatments, and olfactory rehabilitation has only recently grown, and other odors, olfactory characteristics, functions, and humanities have little interest. Therefore, beyond the medical perspective on human olfaction and smell, we intend to increase our understanding and interest in the olfaction, which has been underestimated in importance, through humanistic considerations. The olfaction is also a sense of a person, and its value should be paid attention again. It’s never an inferior sense. Understanding the functions of the underrated human olfaction and re-discovering the lost olfaction and smell culture will enrich life.
嗅觉并不是一种退化的感觉,但它不仅在生存中起着重要的作用,而且在人类的感觉、情感、记忆和社会功能中也起着重要的作用。这是一种复杂而困难的嗅觉特征,直到最近才得到科学的发展。虽然近年来人们对嗅觉的兴趣有所增加,但人们对人类嗅觉功能的特点和功能还不太了解,医学研究也集中在疾病上。事实上,人们对嗅觉疾病的病因、嗅觉功能测试、治疗和嗅觉康复等医学方面的兴趣只是最近才开始增长,而对其他气味、嗅觉特征、功能和人文学科的兴趣则很少。因此,我们打算超越医学对人类嗅觉和嗅觉的视角,通过人文的考虑,增加我们对嗅觉的理解和兴趣,这是一直被低估的重要性。嗅觉也是一个人的一种感觉,它的价值应该再次得到重视。这绝不是低人一等的感觉。认识被低估的人类嗅觉的功能,重新发现失去的嗅觉和嗅觉文化,将丰富生活。
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引用次数: 0
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Q4 Medicine Pub Date : 2023-09-25 DOI: 10.3342/kjorl-hns.2023.00759
Jeon Mi Lee, Young Joon Seo
An implantable bone conduction hearing aid is a device that assists hearing by transmitting sound vibration through the bone. It is suitable not only for patients with conductive hearing loss and congenital external aural atresia but also for those with unilateral hearing loss, chronic otitis media, or patients whose normal structure has been destroyed due to previous surgery. In this paper, we introduce a novel surgical technique for an implantable bone conduction hearing aid (BAHA® Attract) that can be performed through minimal incision in a short time under local anesthesia based on accurate anatomical characteristics. We believe this novel technique could provide convenience for patients and surgeons. Additionally, through this technique, we can expect that various types of implantable bone conduction hearing aids that function effectively and safely can be provided for patients.
植入式骨传导助听器是一种通过骨传递声音振动来帮助听力的装置。不仅适用于传导性听力损失、先天性外耳闭锁患者,也适用于单侧听力损失、慢性中耳炎、既往手术导致正常结构破坏的患者。在本文中,我们介绍了一种新的植入式骨传导助听器的手术技术(BAHA<sup>®</sup>根据准确的解剖特征,在局部麻醉下,在短时间内通过最小的切口进行手术。我们相信这项新技术可以为病人和外科医生提供方便。此外,通过这项技术,我们可以期望为患者提供有效、安全的各种类型的植入式骨传导助听器。
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引用次数: 0
A Case of Huge Congenital Cholesteatoma of Petrous Apex Treated With Translabyrinthine Marsupialization 经迷路有袋化术治疗先天性巨大胆脂瘤石尖1例
Q4 Medicine Pub Date : 2023-09-25 DOI: 10.3342/kjorl-hns.2023.00458
Jaehyung Park, Euyhyun Park, Gi jung Im, Hak Hyun Jung
Congenital cholesteatoma is rare, and especially so for a benign mass to grow from the squamous epithelium and the petrous apex as a location for this cancer. Surgery of the petrous apex cholesteatoma is challenging due to the location of the lesion and the need to preserve adjacent structures such as the dura mater, internal carotid artery, and internal auditory canal. Imaging studies, including CT and MRI, were crucial in guiding the surgical approach. This report describes a 40-year-old male patient with a large congenital cholesteatoma involving the petrous apex and temporal bone. The patient presented with a headache, hearing loss that persisted despite prior medical treatment. The cholesteatoma was surgically marsupialized through translabyrinthine approach, and the patient has remained stable for over 20 years. This report underscores the importance of considering the anatomical location and relationships of the lesion and adjacent structures when determining the surgical approach for congenital cholesteatoma involving the petrous apex and temporal bone.
先天性胆脂瘤是罕见的,尤其是良性肿块从鳞状上皮和岩尖生长为这种癌症的位置。由于病变的位置和需要保留邻近的结构,如硬脑膜、颈内动脉和内耳道,岩尖胆脂瘤的手术是具有挑战性的。影像学研究,包括CT和MRI,对指导手术入路至关重要。本报告描述一位40岁男性病患,患有一大块先天性胆脂瘤,累及颞骨及岩尖。患者表现为头痛,听力下降,尽管先前进行了治疗,但仍持续存在。经迷路入路手术切除胆脂瘤,患者病情稳定超过20年。本报告强调了在确定先天性胆脂瘤的手术入路时,考虑病变和邻近结构的解剖位置和关系的重要性。
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引用次数: 0
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Q4 Medicine Pub Date : 2023-09-25 DOI: 10.3342/kjorl-hns.2023.00710
Jae Sang Han, Yeonji Kim, Eul Seung Hwang, Ji Hyung Lim, So Yong Park, Jeong Hae Park, Jae-Hyun Seo, Shi Nae Park
Background and Objectives The hearing in noise test (HINT) or sound localization test (SLT) is used as the standardized assessment for contralateral routing of signals (CROS) and bilateral microphones with contralateral routing of signals (BiCROS) hearing aids (HAs). However, implementing HINT or SLT can be challenging in most ENT clinics. In this study, we propose a new feasible method specifically designed for conducting a sound field hearing test for CROS and BiCROS HA users.Subjects and Method CROS/BiCROS HA users who visited Seoul St. Mary’s hospital between 2019 and 2021 were enrolled for the study. SLT was conducted in a sound-proof room equipped with two speakers positioned at a 45° angle from the patient on each side: noise stimuli were presented to the better ear the headphone patient was wearing while signals were presented to the worse ear via the speakers in the room. To validate the sound field test, a correlation analysis was conducted using the Bern benefit in single-sided deafness and the Korean version of the International Outcome Inventory for Hearing Aids (K-IOI-HA) Questionnaires.Results The aided speech discrimination score was significantly higher in the signal 60 dB HL/masking 50 dB HL condition than 50 dB HL/masking 50 dB HL condition (p<0.05). A significant correlation was found between the gain of sound field speech audiometry and the K-IOI-HA questionnaire (p<0.05).Conclusion Our novel sound field hearing test for CROS/BiCROS HA users, which presents appropriate noise stimuli via headphones to the better ear, appears to be a feasible approach for CROS/BiCROS HA users.
背景与目的采用噪声听力测试(HINT)或声音定位测试(SLT)作为对侧信号走线(CROS)和双侧麦克风配对侧信号走线(BiCROS)助听器(HAs)的标准化评估。然而,在大多数耳鼻喉科诊所实施HINT或SLT可能具有挑战性。在这项研究中,我们提出了一种新的可行的方法,专门设计用于进行声场听力测试的CROS和BiCROS HA用户。在2019年至2021年期间访问首尔圣玛丽医院的CROS/BiCROS HA用户被纳入研究。SLT是在一个隔音的房间里进行的,房间两边各有两个扬声器,与患者成45°角。噪音刺激被呈现给患者戴耳机的较好的耳朵,而信号通过房间里的扬声器呈现给较差的耳朵。为了验证声场测试,使用单侧耳聋的Bern效益和韩国版助听器国际结果清单(K-IOI-HA)问卷进行了相关分析。结果在信号60 dB HL/屏蔽50 dB HL条件下,辅助语音识别得分显著高于50 dB HL/屏蔽50 dB HL条件(<i>p</i><0.05)。声场语音测听增益与K-IOI-HA问卷存在显著相关(<i>p</i><0.05)。结论本文提出的新型CROS/BiCROS HA使用者声场听力测试方法,通过耳机向右耳提供适当的噪声刺激,对于CROS/BiCROS HA使用者是一种可行的方法。
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引用次数: 0
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Korean Journal of Otorhinolaryngology-head and Neck Surgery
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