Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.3.171
Leejin Lim, Byeongsam Chu, S. Lee, Bounleuane Douangdeuane, Heesang Song
The purpose of this study was to investigate the anti-melanogenic effects of the extracts from Decaschistia intermedia craib (EDI). In this study, we examined the effects of EDI on mushroom tyrosinase activity in in vitro, melanin contents, and expression levels of mRNA and proteins of melanogenesis-related genes in B16F10 melanoma cells. The treatment of EDI significantly decreased both tyrosinase activity and melanin contents in B16F10 cells with dose-dependent manner. In addition, we found that the expression of mRNA or proteins of melanogenic proteins, such as, a-melanocyte-stimulating hormone (aMSH)-induced microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein-1 (TRP-1), and TRP-2 was significantly downregulated with dose-dependent manner in the EDI-treated B16F10 cells compared to controls. Our results suggest that the EDI inhibits cellular melanogenesis through downregulation of a-MSH-stimulated melanin synthesis. Thus EDI may potentially be an effective whitening agent.
{"title":"Inhibitory Effects of Decaschistia intermedia Craib Extract on Melanin Synthesis","authors":"Leejin Lim, Byeongsam Chu, S. Lee, Bounleuane Douangdeuane, Heesang Song","doi":"10.22889/KJP.2020.51.3.171","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.3.171","url":null,"abstract":" The purpose of this study was to investigate the anti-melanogenic effects of the extracts from Decaschistia intermedia craib (EDI). In this study, we examined the effects of EDI on mushroom tyrosinase activity in in vitro, melanin contents, and expression levels of mRNA and proteins of melanogenesis-related genes in B16F10 melanoma cells. The treatment of EDI significantly decreased both tyrosinase activity and melanin contents in B16F10 cells with dose-dependent manner. In addition, we found that the expression of mRNA or proteins of melanogenic proteins, such as, a-melanocyte-stimulating hormone (aMSH)-induced microphthalmia associated transcription factor (MITF), tyrosinase, tyrosinase related protein-1 (TRP-1), and TRP-2 was significantly downregulated with dose-dependent manner in the EDI-treated B16F10 cells compared to controls. Our results suggest that the EDI inhibits cellular melanogenesis through downregulation of a-MSH-stimulated melanin synthesis. Thus EDI may potentially be an effective whitening agent.","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"4 1","pages":"171-177"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75417525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.2.139
Ga-ram Kim, Eun-Nam Kim, Jeong Gil-Saeng
{"title":"Simultaneous Quantitative Analysis of Flavonoids Isolated from the Leaves of Diospyros kaki","authors":"Ga-ram Kim, Eun-Nam Kim, Jeong Gil-Saeng","doi":"10.22889/KJP.2020.51.2.139","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.2.139","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"31 1","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73863485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.3.207
G. Seo, A. Kim, Byoungsik Pyo, K. Lee
The analysis method for qualitative analysis of the screening method that can be performed prior to the quantitative analysis of individual pesticide was reviewed in order to meet the safety standards that are being strengthened in the field of pesticide residue testing of herbal medicines. Among the residual pesticides presented in the Korean Pharmacopoeia, 56 pesticides, excluding 15 pesticides that need to be individually analyzed, were selected for analysis using QuEChERS preprocessing and GC-MS/MS, which are used in the existing agricultural products field. For each pesticide, the detection limit level of 0.001-0.005 mg/kg and the quantitative limit level of 0.002-0.017 mg/kg were confirmed. In the recovery test in which the standard was treated at a concentration of 0.02 mg/kg, it was confirmed that the proportion of pesticides satisfying the recovery of 70-120% was 85.7-96.4% for each herbal medicine, so it was confirmed that it was a level that could be reviewed by the screening method.
{"title":"Analysis of Pesticides in Herbal Medicine by QuEChERS and GC-MS/MS","authors":"G. Seo, A. Kim, Byoungsik Pyo, K. Lee","doi":"10.22889/KJP.2020.51.3.207","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.3.207","url":null,"abstract":" The analysis method for qualitative analysis of the screening method that can be performed prior to the quantitative analysis of individual pesticide was reviewed in order to meet the safety standards that are being strengthened in the field of pesticide residue testing of herbal medicines. Among the residual pesticides presented in the Korean Pharmacopoeia, 56 pesticides, excluding 15 pesticides that need to be individually analyzed, were selected for analysis using QuEChERS preprocessing and GC-MS/MS, which are used in the existing agricultural products field. For each pesticide, the detection limit level of 0.001-0.005 mg/kg and the quantitative limit level of 0.002-0.017 mg/kg were confirmed. In the recovery test in which the standard was treated at a concentration of 0.02 mg/kg, it was confirmed that the proportion of pesticides satisfying the recovery of 70-120% was 85.7-96.4% for each herbal medicine, so it was confirmed that it was a level that could be reviewed by the screening method.","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"20 1","pages":"207-216"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89189454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.3.158
J. H. Ko, Jihyun Keum, J. W. Jung, Hyun Kyu Jhee, Seung-pyo Hong, Myong-Jo Kim, W. Chun, Y. Kwon
Three coumarins, one chromone, and a phytosterol were isolated from the stem of Ostericum koreanum. Basis on the spectral data, we determined to be the structures of isolated compounds as bergapten, xanthotoxin, auraptenol, hamaudol, and mixture of phytosterols. Auraptenol was isolated for the first time from this plant.
{"title":"Chemical Constituents of Ostericum koreanum Stem","authors":"J. H. Ko, Jihyun Keum, J. W. Jung, Hyun Kyu Jhee, Seung-pyo Hong, Myong-Jo Kim, W. Chun, Y. Kwon","doi":"10.22889/KJP.2020.51.3.158","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.3.158","url":null,"abstract":" Three coumarins, one chromone, and a phytosterol were isolated from the stem of Ostericum koreanum. Basis on the spectral data, we determined to be the structures of isolated compounds as bergapten, xanthotoxin, auraptenol, hamaudol, and mixture of phytosterols. Auraptenol was isolated for the first time from this plant.","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"32 1","pages":"158-162"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87942754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.4.255
Lee Sang Myung
{"title":"Three Hydroxylated Ginsenosides from Heat Treatmented Ginseng","authors":"Lee Sang Myung","doi":"10.22889/KJP.2020.51.4.255","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.4.255","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"16 1","pages":"255-263"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86150762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.2.131
Kim Ha Rim, Kimel Sol, Kim Sang-Jun, Jeong Seung-il, Kim Seon-young
{"title":"Rhynchosia volubilis Lour. and Beta vulgaris Modulate Extracts Regulate UV-Induced Retinal Pigment Epithelial Cell and Eye Damage in Mice","authors":"Kim Ha Rim, Kimel Sol, Kim Sang-Jun, Jeong Seung-il, Kim Seon-young","doi":"10.22889/KJP.2020.51.2.131","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.2.131","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"78 1","pages":"131-138"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83772993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.4.332
Hyun Joo Lee, J. Nho, Beodeul Yang, K. Woo, Yong-Jin Song, Enoch Lee, Yoong-Jae Lee, T. Hwang, Sun-Ra Kim, Hyun-Woo Cho, Y. Chung, M. Lee
{"title":"Anti-osteoporosis Effects of Ethanol Extract of Lentinula edodes in Ovariectomized Rats","authors":"Hyun Joo Lee, J. Nho, Beodeul Yang, K. Woo, Yong-Jin Song, Enoch Lee, Yoong-Jae Lee, T. Hwang, Sun-Ra Kim, Hyun-Woo Cho, Y. Chung, M. Lee","doi":"10.22889/KJP.2020.51.4.332","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.4.332","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"9 1","pages":"332-339"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83517114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.4.340
Eun Byeol Lee, Ji-Hye Choi, Hwan-Hee Jang, H. Hong, Hae-Jeung Lee, H. Jeong, Sung-Jin Lee, S. Lee
{"title":"Effects of Aged Platycodon grandiflorum on Cyclophosphamide-induced Immunosuppression in Mice","authors":"Eun Byeol Lee, Ji-Hye Choi, Hwan-Hee Jang, H. Hong, Hae-Jeung Lee, H. Jeong, Sung-Jin Lee, S. Lee","doi":"10.22889/KJP.2020.51.4.340","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.4.340","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"88 1","pages":"340-348"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78441133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.22889/KJP.2020.51.2.122
H. Jo, Dae-sung Kim, Jung-Young Kim, Young Mi Park, D. Shin, Hak-Yong Lee, Hoon Kim, Lee Dong-Sung, cho, seongwan
{"title":"Anti-inflammatory Effect of Herbal Complex HP-04 on Degenerative Osteoarthritis","authors":"H. Jo, Dae-sung Kim, Jung-Young Kim, Young Mi Park, D. Shin, Hak-Yong Lee, Hoon Kim, Lee Dong-Sung, cho, seongwan","doi":"10.22889/KJP.2020.51.2.122","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.2.122","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"7 1","pages":"122-130"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82205099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anti-inflammatory Effect of p-Hydroxycinnamic Acid on HT-29 Intestinal Cells and Its Therapeutic Effect of Immune Bowel Disease","authors":"Hyun-Su Lee, Seungho Lee, Hyukjae Choi, Jeong Gil-Saeng","doi":"10.22889/KJP.2020.51.2.107","DOIUrl":"https://doi.org/10.22889/KJP.2020.51.2.107","url":null,"abstract":"","PeriodicalId":17851,"journal":{"name":"Korean Journal of Pharmacognosy","volume":"415 1","pages":"107-114"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79422123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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