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Septic Shock Prediction for Patients with Missing Data 数据缺失患者感染性休克的预测
Pub Date : 2014-04-01 DOI: 10.1145/2591676
Joyce Ho, Cheng H. Lee, Joydeep Ghosh
Sepsis and septic shock are common and potentially fatal conditions that often occur in intensive care unit (ICU) patients. Early prediction of patients at risk for septic shock is therefore crucial to minimizing the effects of these complications. Potential indications for septic shock risk span a wide range of measurements, including physiological data gathered at different temporal resolutions and gene expression levels, leading to a nontrivial prediction problem. Previous works on septic shock prediction have used small, carefully curated datasets or clinical measurements that may not be available for many ICU patients. The recent availability of a large, rich ICU dataset called MIMIC-II has provided the opportunity for more extensive modeling of this problem. However, such a large clinical dataset inevitably contains a substantial amount of missing data. We investigate how different imputation selection criteria and methods can overcome the missing data problem. Our results show that imputation methods in conjunction with predictive modeling can lead to accurate septic shock prediction, even if the features are restricted primarily to noninvasive measurements. Our models provide a generalized approach for predicting septic shock in any ICU patient.
脓毒症和脓毒性休克是重症监护病房(ICU)患者常见且可能致命的疾病。因此,早期预测有脓毒性休克危险的患者对于尽量减少这些并发症的影响至关重要。脓毒性休克风险的潜在适应症范围广泛,包括在不同时间分辨率和基因表达水平下收集的生理数据,这导致了一个重要的预测问题。先前关于感染性休克预测的工作使用了小的、精心策划的数据集或临床测量,这些数据集或临床测量可能不适用于许多ICU患者。最近,一个名为MIMIC-II的大型、丰富的ICU数据集的可用性为该问题的更广泛建模提供了机会。然而,如此庞大的临床数据集不可避免地包含了大量的缺失数据。我们研究了不同的输入选择标准和方法如何克服数据缺失问题。我们的研究结果表明,即使这些特征主要局限于非侵入性测量,与预测建模相结合的imputation方法也可以导致准确的脓毒性休克预测。我们的模型为预测任何ICU患者的脓毒性休克提供了一种通用的方法。
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引用次数: 39
Risk Mitigation Decisions for IT Security IT安全的风险缓解决策
Pub Date : 2014-04-01 DOI: 10.1145/2576757
M. Yeo, E. Rolland, Jackie Rees Ulmer, Raymond A. Patterson
Enterprises must manage their information risk as part of their larger operational risk management program. Managers must choose how to control for such information risk. This article defines the flow risk reduction problem and presents a formal model using a workflow framework. Three different control placement methods are introduced to solve the problem, and a comparative analysis is presented using a robust test set of 162 simulations. One year of simulated attacks is used to validate the quality of the solutions. We find that the math programming control placement method yields substantial improvements in terms of risk reduction and risk reduction on investment when compared to heuristics that would typically be used by managers to solve the problem. The contribution of this research is to provide managers with methods to substantially reduce information and security risks, while obtaining significantly better returns on their security investments. By using a workflow approach to control placement, which guides the manager to examine the entire infrastructure in a holistic manner, this research is unique in that it enables information risk to be examined strategically.
企业必须将管理信息风险作为其更大的操作风险管理计划的一部分。管理者必须选择如何控制这类信息风险。本文定义了流程风险降低问题,并使用工作流框架提出了一个正式的模型。介绍了三种不同的控制放置方法来解决这一问题,并利用一个包含162个仿真的鲁棒测试集进行了对比分析。使用一年的模拟攻击来验证解决方案的质量。我们发现,与管理者通常用来解决问题的启发式方法相比,数学规划控制放置方法在风险降低和投资风险降低方面产生了实质性的改进。本研究的贡献在于为管理者提供了大量减少信息和安全风险的方法,同时获得更好的安全投资回报。通过使用工作流方法来控制布局,它指导管理者以整体的方式检查整个基础设施,这项研究的独特之处在于它使信息风险能够被战略性地检查。
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引用次数: 13
Postmarketing Drug Safety Surveillance Using Publicly Available Health-Consumer-Contributed Content in Social Media 在社交媒体上使用公开可用的健康消费者贡献内容进行上市后药品安全监测
Pub Date : 2014-04-01 DOI: 10.1145/2576233
Christopher C. Yang, Haodong Yang, Ling Jiang
Postmarketing drug safety surveillance is important because many potential adverse drug reactions cannot be identified in the premarketing review process. It is reported that about 5% of hospital admissions are attributed to adverse drug reactions and many deaths are eventually caused, which is a serious concern in public health. Currently, drug safety detection relies heavily on voluntarily reporting system, electronic health records, or relevant databases. There is often a time delay before the reports are filed and only a small portion of adverse drug reactions experienced by health consumers are reported. Given the popularity of social media, many health social media sites are now available for health consumers to discuss any health-related issues, including adverse drug reactions they encounter. There is a large volume of health-consumer-contributed content available, but little effort has been made to harness this information for postmarketing drug safety surveillance to supplement the traditional approach. In this work, we propose the association rule mining approach to identify the association between a drug and an adverse drug reaction. We use the alerts posted by Food and Drug Administration as the gold standard to evaluate the effectiveness of our approach. The result shows that the performance of harnessing health-related social media content to detect adverse drug reaction is good and promising.
上市后药物安全监测很重要,因为在上市前审查过程中无法识别许多潜在的药物不良反应。据报道,约5%的住院病人是由于药物不良反应,最终造成许多人死亡,这是公共卫生方面的一个严重问题。目前,药品安全检测在很大程度上依赖于自愿报告系统、电子病历或相关数据库。在提交报告之前往往有一段时间的延迟,而且只有一小部分保健消费者所经历的药物不良反应得到了报告。鉴于社交媒体的普及,许多健康社交媒体网站现在可供健康消费者讨论任何与健康有关的问题,包括他们遇到的药物不良反应。有大量的健康消费者提供的内容,但很少努力利用这些信息进行上市后药物安全监测,以补充传统方法。在这项工作中,我们提出了关联规则挖掘方法来识别药物和药物不良反应之间的关联。我们使用食品和药物管理局发布的警报作为评估我们方法有效性的金标准。结果表明,利用与健康相关的社交媒体内容来检测药物不良反应的表现是良好和有希望的。
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引用次数: 72
Mining Deviations from Patient Care Pathways via Electronic Medical Record System Audits 通过电子病历系统审计从患者护理路径中挖掘偏差
Pub Date : 2013-12-01 DOI: 10.1145/2544102
He Zhang, S. Mehrotra, David M. Liebovitz, Carl A. Gunter, B. Malin
In electronic medical record (EMR) systems, administrators often provide EMR users with broad access privileges, which may leave the system vulnerable to misuse and abuse. Given that patient care is based on a coordinated workflow, we hypothesize that care pathways can be represented as the progression of a patient through a system and introduce a strategy to model the patient’s flow as a sequence of accesses defined over a graph. Elements in the sequence correspond to features associated with the access transaction (e.g., reason for access). Based on this motivation, we model patterns of patient record usage, which may indicate deviations from care workflows. We evaluate our approach using several months of data from a large academic medical center. Empirical results show that this framework finds a small portion of accesses constitute outliers from such flows. We also observe that the violation patterns deviate for different types of medical services. Analysis of our results suggests greater deviation from normal access patterns by nonclinical users. We simulate anomalies in the context of real accesses to illustrate the efficiency of the proposed method for different medical services. As an illustration of the capabilities of our method, it was observed that the area under the receiver operating characteristic (ROC) curve for the Pediatrics service was found to be 0.9166. The results suggest that our approach is competitive with, and often better than, the existing state-of-the-art in its outlier detection performance. At the same time, our method is more efficient, by orders of magnitude, than previous approaches, allowing for detection of thousands of accesses in seconds.
在电子医疗记录(EMR)系统中,管理员通常为EMR用户提供广泛的访问权限,这可能使系统容易被误用和滥用。鉴于患者护理是基于协调的工作流程,我们假设护理路径可以表示为患者通过系统的进展,并引入一种策略,将患者流程建模为定义在图上的访问序列。序列中的元素对应于与访问事务相关的特征(例如,访问原因)。基于这一动机,我们建立了患者记录使用模式的模型,这可能表明与护理工作流程的偏差。我们使用一个大型学术医疗中心几个月的数据来评估我们的方法。实证结果表明,该框架发现一小部分访问构成了此类流的异常值。我们还注意到,不同类型的医疗服务的违反模式有所不同。分析我们的结果表明,更大的偏离正常访问模式的非临床用户。我们模拟了真实访问环境中的异常情况,以说明所提出的方法对不同医疗服务的效率。为了说明我们的方法的能力,观察到儿科服务的受试者工作特征(ROC)曲线下的面积为0.9166。结果表明,我们的方法在异常值检测性能方面与现有的最先进的方法相竞争,并且通常优于现有的方法。与此同时,我们的方法比以前的方法效率更高,可以在几秒钟内检测到数千个访问。
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引用次数: 27
Business Benefits or Incentive Maximization? Impacts of the Medicare EHR Incentive Program at Acute Care Hospitals 商业利益还是激励最大化?医疗保险EHR激励计划对急症护理医院的影响
Pub Date : 2013-12-01 DOI: 10.1145/2543900
Rajesh Mirani, Anju Harpalani
This study investigates the influence of the Medicare EHR Incentive Program on EHR adoption at acute care hospitals and the impact of EHR adoption on operational and financial efficiency/effectiveness. It finds that even before joining the incentive program, adopter hospitals had more efficient and effective Medicare operations than those of non-adopters. Adopters were also financially more efficient. After joining the program, adopter hospitals treated significantly more Medicare patients by shortening their stay durations, relative to their own non-Medicare patients and also to patients at non-adopter hospitals, even as their overall capacity utilization remained relatively unchanged. The study concludes that many of these hospitals had implemented EHR even before the initiation of the incentive program. It further infers that they joined this program with opportunistic intentions of tapping into incentive payouts which they maximized by taking on more Medicare patients. These findings give credence to critics of the program who have questioned its utility and alleged that it serves only to reward existing users of EHR technologies.
本研究旨在探讨医疗保险电子健康档案激励计划对急症护理医院电子健康档案采用的影响,以及电子健康档案采用对营运及财务效率/效能的影响。研究发现,即使在加入激励计划之前,采用医疗保险的医院也比未采用医疗保险的医院有更高的效率和效果。采用者在财务上也更有效率。加入该计划后,相对于他们自己的非医疗保险患者和非医疗保险医院的患者,采用该计划的医院通过缩短住院时间,治疗了更多的医疗保险患者,即使他们的总体能力利用率保持相对不变。研究得出结论,这些医院中的许多甚至在激励计划启动之前就已经实施了电子病历。这进一步推断,他们加入这个项目是出于机会主义的意图,即利用激励支出,通过接受更多的医疗保险患者来实现激励支出的最大化。这些发现为该项目的批评者提供了证据,他们质疑该项目的实用性,并声称该项目的目的只是为了奖励电子病历技术的现有用户。
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引用次数: 8
I Can Help You Change! An Empathic Virtual Agent Delivers Behavior Change Health Interventions 我能帮你改变!移情虚拟代理提供行为改变健康干预
Pub Date : 2013-12-01 DOI: 10.1145/2544103
C. Lisetti, R. Amini, Ugan Yasavur, N. Rishe
We discuss our approach to developing a novel modality for the computer-delivery of Brief Motivational Interventions (BMIs) for behavior change in the form of a personalized On-Demand VIrtual Counselor (ODVIC), accessed over the internet. ODVIC is a multimodal Embodied Conversational Agent (ECA) that empathically delivers an evidence-based behavior change intervention by adapting, in real-time, its verbal and nonverbal communication messages to those of the user’s during their interaction. We currently focus our work on excessive alcohol consumption as a target behavior, and our approach is adaptable to other target behaviors (e.g., overeating, lack of exercise, narcotic drug use, non-adherence to treatment). We based our current approach on a successful existing patient-centered brief motivational intervention for behavior change---the Drinker’s Check-Up (DCU)---whose computer-delivery with a text-only interface has been found effective in reducing alcohol consumption in problem drinkers. We discuss the results of users’ evaluation of the computer-based DCU intervention delivered with a text-only interface compared to the same intervention delivered with two different ECAs (a neutral one and one with some empathic abilities). Users rate the three systems in terms of acceptance, perceived enjoyment, and intention to use the system, among other dimensions. We conclude with a discussion of how our positive results encourage our long-term goals of on-demand conversations, anytime, anywhere, with virtual agents as personal health and well-being helpers.
我们讨论了我们开发一种新的方法,以个性化的按需虚拟咨询师(ODVIC)的形式,通过互联网访问,为行为改变提供简短动机干预(bmi)的计算机交付。ODVIC是一个多模态具体化会话代理(ECA),通过实时调整其口头和非口头沟通信息,在用户交互过程中提供基于证据的行为改变干预。我们目前的工作重点是将过度饮酒作为目标行为,我们的方法也适用于其他目标行为(例如,暴饮暴食、缺乏运动、使用麻醉剂、不坚持治疗)。我们目前的方法是基于一个成功的以病人为中心的行为改变的简短动机干预——饮酒者检查(DCU)——它的计算机传递与一个纯文本界面被发现有效地减少了问题饮酒者的酒精摄入量。我们讨论了用户对使用纯文本界面提供的基于计算机的DCU干预的评估结果,并将其与使用两个不同的eca(一个中立的eca和一个具有一些共情能力的eca)提供的相同干预进行比较。用户根据接受度、感知到的享受、使用系统的意图等维度对这三个系统进行评分。最后,我们讨论了我们的积极结果如何促进我们的长期目标,即随时随地使用虚拟代理作为个人健康和福祉助手进行按需对话。
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引用次数: 196
Smart Health and Wellbeing 智能健康和幸福
Pub Date : 2013-12-01 DOI: 10.1145/2555810.2555811
Christopher C. Yang, G. Leroy, S. Ananiadou
Healthcare informatics has drawn substantial attention in recent years. Current work on healthcare informatics is highly interdisciplinary involving methodologies from computing, engineering, information science, behavior science, management science, social science, as well as many different areas in medicine and public health. Three major tracks, (i) systems, (ii) analytics, and (iii) human factors, can be identified. The systems track focuses on healthcare system architecture, framework, design, engineering, and application; the analytics track emphasizes data/information processing, retrieval, mining, analytics, as well as knowledge discovery; the human factors track targets the understanding of users or context, interface design, and user studies of healthcare applications. In this article, we discuss some of the latest development and introduce several articles selected for this special issue. We envision that the development of computing-oriented healthcare informatics research will continue to grow rapidly. The integration of different disciplines to advance the healthcare and wellbeing of our society will also be accelerated.
近年来,医疗保健信息学引起了广泛关注。目前医疗保健信息学的工作是高度跨学科的,涉及计算、工程、信息科学、行为科学、管理科学、社会科学以及医学和公共卫生的许多不同领域的方法。可以确定三个主要轨道,(i)系统,(ii)分析和(iii)人为因素。系统跟踪侧重于医疗保健系统架构,框架,设计,工程和应用;分析学方向强调数据/信息处理、检索、挖掘、分析以及知识发现;人为因素跟踪的目标是对用户或上下文的理解、界面设计和医疗保健应用程序的用户研究。在本文中,我们讨论了一些最新的发展,并介绍了为本期特刊选择的几篇文章。我们预计,以计算为导向的医疗信息研究的发展将继续快速增长。不同学科的整合也将加快,以促进我们社会的医疗保健和福祉。
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引用次数: 40
Embodying Care in Matilda: An Affective Communication Robot for Emotional Wellbeing of Older People in Australian Residential Care Facilities 在玛蒂尔达中体现关怀:澳大利亚养老院老年人情感健康的情感沟通机器人
Pub Date : 2013-12-01 DOI: 10.1145/2544104
R. Khosla, Mei-Tai Chu
Ageing population is at the center of the looming healthcare crisis in most parts of the developed and developing world. Australia, like most of the western world, is bracing up for the looming ageing population crisis, spiraling healthcare costs, and expected serious shortage of healthcare workers. Assistive service and companion (social) robots are being seen as one of the ways for supporting aged care facilities to meet this challenge and improve the quality of care of older people including mental and physical health outcomes, as well as to support healthcare workers in personalizing care. In this article, the authors report on the design and implementation of first-ever field trials of Matilda, a human-like assistive communication (service and companion) robot for improving the emotional well-being of older people in three residential care facilities in Australia involving 70 participants. The research makes several unique contributions including Matilda’s ability to break technology barriers, positively engage older people in group and one-to-one activities, making these older people productive and useful, helping them become resilient and cope better through personalization of care, and finally providing them sensory enrichment through Matilda’s multimodal communication capabilities.
在大多数发达国家和发展中国家,人口老龄化是迫在眉睫的医疗危机的核心问题。像大多数西方国家一样,澳大利亚正在为迫在眉睫的人口老龄化危机、不断上升的医疗成本以及预计会出现的严重医护人员短缺做准备。辅助服务和伴侣(社交)机器人被视为支持老年护理机构应对这一挑战、提高老年人护理质量(包括精神和身体健康结果)以及支持保健工作者进行个性化护理的方法之一。在这篇文章中,作者报告了Matilda的首次现场试验的设计和实施,Matilda是一种类似人类的辅助沟通(服务和伴侣)机器人,用于改善澳大利亚三家住宿护理机构中70名参与者的老年人的情绪健康。该研究做出了一些独特的贡献,包括Matilda打破技术障碍的能力,积极参与老年人群体和一对一活动,使这些老年人富有成效和有用,帮助他们变得有弹性,通过个性化护理更好地应对,最后通过Matilda的多模式沟通能力为他们提供感官丰富。
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引用次数: 55
Modeling Throughput of Emergency Departments via Time Series: An Expectation Maximization Algorithm 基于时间序列的急诊科吞吐量建模:一种期望最大化算法
Pub Date : 2013-12-01 DOI: 10.1145/2544105
Zidong Wang, J. Eatock, S. McClean, Dongmei Liu, Xiaohui Liu, T. Young
In this article, the expectation maximization (EM) algorithm is applied for modeling the throughput of emergency departments via available time-series data. The dynamics of emergency department throughput is developed and evaluated, for the first time, as a stochastic dynamic model that consists of the noisy measurement and first-order autoregressive (AR) stochastic dynamic process. By using the EM algorithm, the model parameters, the actual throughput, as well as the noise intensity, can be identified simultaneously. Four real-world time series collected from an emergency department in West London are employed to demonstrate the effectiveness of the introduced algorithm. Several quantitative indices are proposed to evaluate the inferred models. The simulation shows that the identified model fits the data very well.
在本文中,期望最大化(EM)算法应用于建模的急诊科的吞吐量通过可用的时间序列数据。本文首次将急诊科吞吐率动力学作为一个由噪声测量和一阶自回归(AR)随机动态过程组成的随机动态模型进行了发展和评价。利用该算法可以同时识别出模型参数、实际吞吐量和噪声强度。从伦敦西部的一个急诊科收集的四个真实世界的时间序列被用来证明所引入的算法的有效性。提出了几个定量指标来评价推断的模型。仿真结果表明,所识别的模型与数据拟合良好。
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引用次数: 8
Real Options and System Dynamics for Information Technology Investment Decisions: Application to RFID Adoption in Retail 信息技术投资决策的实物期权和系统动力学:RFID在零售中的应用
Pub Date : 2013-10-01 DOI: 10.1145/2517309
Narges Kasiri, R. Sharda
We propose a unique combination of system dynamics and real options into a robust and innovative model for analyzing return on investments in IT. Real options modeling allows a cost benefit analysis to take into account managerial flexibilities when there is uncertainty in the investment, while system dynamics can build a predictive model, in which one can simulate different real-life and hypothetical scenarios in order to provide measurements that can be used in the real options model. Our return on the investment model combines these long-established quantitative techniques in a novel manner. This study applies this robust hybrid model to a challenging IT investment problem: adoption of RFID in retail. Item-level RFID is the next generation of identification technology in the retail sector. Our method can help managers to overcome the complexity and uncertainties in the investment timing of this technology. We analyze the RFID considerations in retail decision-making using real data compiled from a Delphi study. Our model demonstrates how the cost and benefits of such an investment change over time. The results highlight the variable cost of RFID tags as the key factor in the decision process concerning whether to immediately adopt or postpone the use of RFID in retail. Our exploratory work suggests that it is possible to combine merchandising and pricing issues in addition to the traditional supply chain management issues in studying any multifaceted problem in retail.
我们提出了一个独特的组合系统动力学和实物期权到一个强大的和创新的模型来分析投资回报在IT。实物期权建模允许成本效益分析在投资存在不确定性时考虑管理灵活性,而系统动力学可以建立预测模型,其中可以模拟不同的现实生活和假设场景,以便提供可用于实物期权模型的测量。我们的投资回报模型以一种新颖的方式结合了这些长期建立的定量技术。本研究将此稳健混合模型应用于具有挑战性的IT投资问题:RFID在零售业的采用。物品级RFID是零售领域的下一代识别技术。我们的方法可以帮助管理者克服该技术投资时机的复杂性和不确定性。我们使用从德尔菲研究中编译的真实数据来分析RFID在零售决策中的考虑因素。我们的模型展示了这种投资的成本和收益是如何随时间变化的。研究结果强调RFID标签的可变成本是决定是否立即采用或推迟在零售中使用RFID的关键因素。我们的探索性工作表明,除了传统的供应链管理问题外,还可以将销售和定价问题结合起来研究零售中的任何多方面问题。
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引用次数: 10
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