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Renovated Tokyo’s Clinical Guidelines for treatment of an acute cholangitis and an acute cholecystitis, 2018 yr (Tokyo Guidelines, 2018) 2018年新版《东京急性胆管炎和急性胆囊炎临床指南》(东京指南,2018年)
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.7-8.03
O. Usenko, V. Desyateryk, S. P. Mіkhno, E. O. Okhotnik
Renovated Tokyo’s Clinical Guidelines for treatment of an acute cholangitis and an acute cholecystitis, 2018 yr (Tokyo Guidelines, 2018)
2018年新版《东京急性胆管炎和急性胆囊炎临床指南》(东京指南,2018年)
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引用次数: 0
Postoperative acute pancreatitis 术后急性胰腺炎
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.7-8.49
S. Chooklin, S. Chuklin, R. Barylyak
Postoperative acute pancreatitis
术后急性胰腺炎
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引用次数: 0
The changes of parameters of the systemic inflammatory answer syndrome on early stages of complicated acute pancreatitis 复杂急性胰腺炎早期全身炎性应答综合征参数的变化
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.9-10.11
R. M. Agayev, A. A. Mamadov, F. S. Idrisov, E. A. Iskandarov, E. Aliyeva
Objective. To determine a prognostic validity of parameters of the systemic inflammatory answer syndrome for early diagnosis of an acute pancreatitis severity and prognostication of the pathological processes exacerbation. Materials and methods. The treatment results in 71 patients, suffering an acute pancreatitis, were analyzed. An acute pancreatitis in a light form was diagnosed in 39 patients (Group I), and in a severe one-in 32 patients (GroupII). In the patients while hospitalization and in consequent two days an absolute quantity of leucocytes, relative quantity of immature granulocytes and value of neutrophil-lymphocytic ratio, concentration of C-reactive protein were investigated. ROC-curve was applied while doing calculation of the «cut-off» point for neutrophil-lymphocytic ratio and studied a three-week survival, using Kaplan-Meyer method. Results. In the Group II patients the leucocytes quantity was trustworthily more - (15.4 ± 2.3) × 109/l, than in patients of Group I - (12.7 ± 1.2) × 109/l. Relative quantity of neutrophils and immature granulocytes was high in Group II, but absolute quantity of lymphocytes in these patients was lower, than in the patients of Group I. In accordance to the neutrophil-lymphocytic ratio in the admittance day the Group II differed from Group I statistically significant - 12.6 ± 1.4 and 9.78 ± 1.3 accordingly. In Group I during consequent two days this marker have lowered, аnd in Group II demonstrated further raising (p < 0.05). Optimal point of «cut-off» for neutrophil-lymphocytic ratio was determined as 10.5. The three-week survival of patients with the neutrophil-lymphocytic ratio value 10.5 has constituted 95,9%. In the values of neutrophil-lymphocytic ratio more than 10.5 a survival have lowered down to 79.2%,and mortality have been raised up to 21/8%. Relative quantity of immature granulocytes in Group I have constituted (0.39 ± 0.21)%, and in Group II - (1.7 ± 0.51)%. Doing analysis of square under the ROC-curve the threshold meaning for immature granulocytes was determined as 0.81%. In the admittance day the Groups did not differ for index of C-reactive protein. But, on the second day the C-reactive protein concentration have been enhanced by 55.3% in Group II and was significantly higher, than in Group I. Multifactorial analysis have shown, that diabetes mellitus constitutes independent predictor of risk for the septic complications occurrence. Negative impact of hepatic adipose dystrophy on occurrence and progress of polyorgan insufficiency in patients with pancreonecrosis were revealed as well. Conclusion.There was proved, that studying of values of neutrophil-lymphocytic ratio permits to prognosticate the survival indices in patients, suffering an acute pancreatitis of early stage. The level of C-reactive protein on the second day after admittance takes effect of prognostic significance and must be applied as a marker for the further clinical signs prognostication. In controversial cases the
目标。确定系统性炎症反应综合征参数对早期诊断急性胰腺炎严重程度和预测病理过程恶化的预后有效性。材料和方法。对71例急性胰腺炎患者的治疗结果进行了分析。39例患者诊断为轻度急性胰腺炎(I组),32例患者诊断为重度急性胰腺炎(I组)。观察患者住院期间及住院后2天白细胞的绝对数量、未成熟粒细胞的相对数量、中性粒细胞与淋巴细胞的比值、c反应蛋白的浓度。在计算中性粒细胞-淋巴细胞比率的“截止”点时应用roc曲线,并使用Kaplan-Meyer方法研究三周生存率。结果。ⅱ组患者白细胞计数(15.4±2.3)× 109/l明显高于ⅰ组(12.7±1.2)× 109/l。ⅱ组患者中性粒细胞和未成熟粒细胞的相对数量较高,但淋巴细胞的绝对数量低于ⅰ组。按照入院日中性粒细胞/淋巴细胞比值,ⅱ组与ⅰ组差异有统计学意义,分别为12.6±1.4和9.78±1.3。第1组在随后的2 d内,该指标有所降低,第2 d进一步升高(p < 0.05)。中性粒细胞与淋巴细胞比值的最佳“临界值”为10.5。中性粒细胞-淋巴细胞比值为10.5的患者3周生存率为95.9%。当中性粒细胞与淋巴细胞比值大于10.5 a时,生存率下降到79.2%,死亡率上升到21.8%。ⅰ组未成熟粒细胞的相对数量为(0.39±0.21)%,ⅱ组为(1.7±0.51)%。roc曲线下方图分析,未成熟粒细胞阈值为0.81%。入院当天各组c反应蛋白指标无显著差异。但是,在第2天,第二组的c反应蛋白浓度提高了55.3%,明显高于第一组。多因素分析表明,糖尿病是脓毒性并发症发生风险的独立预测因子。揭示肝脂肪营养不良对胰脏坏死患者多脏器功能不全发生及进展的负面影响。结论。研究证明,研究中性粒细胞-淋巴细胞比值值可以预测早期急性胰腺炎患者的生存指标。入院后第2天c反应蛋白水平具有预后意义,必须作为进一步临床体征预测的标志。在有争议的病例中,中性粒细胞淋巴细胞和未成熟粒细胞的相对数量有助于决定预后。通过对外周血的简单分析,可以预测急性胰腺炎早期的临床体征。全身性炎症反应综合征参数对判断病变严重程度具有重要意义。
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引用次数: 0
The method of distant preconditioning and results of its application in renal transplantation from the living family donor 远距离预处理方法及其在活体供体肾移植中的应用效果
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.9-10.38
M. Kyrychenko, A. V. Bilyayev, N. Davydenko, A. Bychkova, O. V. Storozhuk
Objective. Elaboration of method for the intraoperative ischemic-reperfusion trauma softening - distant ischemic preconditioning and investigation of results of its introduction into clinical practice. Materials and methods. The method of distant ischemic preconditioning elaborated have included four procedures the air inflation into the flap for the arterial pressure measuring by 40 mm Hg over the level of systolic arterial pressure, 5 min of duration in every one, with consequent 5-minute intervals for the air release from the flap. The procedure of a distant ischemic preconditioning was conducted after introduction into narcosis, but before the donor's nephrectomy in 30 patients (the main group). The procedure was not conducted in 30 such patients. Results. The procedure elaborated permits to enhance the glomerular filtration significantly in 6 and 12 mo, to reduce the rate of partial delay of the transplant functioning, its acute rejection and primary dysfunction. Conclusion. The procedure of a distant ischemic preconditioning elaborated improves the transplanted kidney function.
目标。术中缺血-再灌注损伤软化-远端缺血预处理方法的阐述及应用于临床的效果观察。材料和方法。远端缺血预处理的方法包括四个步骤:向皮瓣充气,测量动脉压,比收缩压高40毫米汞柱,每次持续5分钟,然后间隔5分钟从皮瓣释放空气。30例患者(主要组)在麻醉后、供体肾切除术前进行远端缺血预处理。在30例这样的患者中没有进行手术。结果。该程序允许在6个月和12个月显著增强肾小球滤过,以减少移植功能部分延迟的比率,其急性排斥反应和原发性功能障碍。结论。远端缺血预处理可改善移植肾的功能。
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引用次数: 0
Solid pseudopapillary tumor of the pancreas (Frantz’s tumor) 胰腺实性假乳头状瘤(弗朗茨瘤)
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.7-8.69
D. Coco, S. Leanza, R. Campagnacci
Solid pseudopapillary tumor of the pancreas (Frantz’s tumor)
胰腺实性假乳头状瘤(弗朗茨瘤)
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引用次数: 1
Surgical treatment of the inferior vena cava (IVC) leiomyosarcoma 下腔静脉平滑肌肉瘤的外科治疗
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.9-10.44
V. I. Rusin, S. O. Boiko, V. Rusin, F. V. Gorlenko, S. Boiko, O. V. Syma
Objective. To propose and introduce a diagnostic-treatment algorithm for the inferior vena cava (IVC) leiomyosarcoma into clinical practice. Materials and methods. During last 30 years in Zakarpattya Regional Clinical Hospital Named After Andriy Novak and Zakarpattya Antitumoral Centre were operated 8 patients, suffering the IVC leiomyosarcoma - 7 (87.5%) women and 1 (12.5%) man. Median of the patients' age have constituted 57 yrs old. For characterization of the affection localization in accordance to own views on the subject the classification of the IVC division into 7 segments was applied: infrarenal, іnterrenal, suprarenal, retrohepatic, іnfradiaphragmatic, supradiaphragmatic,іntracardial. Іntravasal localization of the tumor was observed in 3 (37.5%), extravasal - in 1 (12.5%), mixed - in 4 (50%) patients. In all the patients the open laparotomy approach was applied: in 1 (12.5%) patient median laparotomy was performed, and in 7 (87.5%) - bilateral subcostal laparotomy of a «Chevron» type. For the IVC alloprosthesis in 6 (75%) patients a politetrafluoroethylene prosthesis was applied, while in 2 (25%) - Gore-tex prosthesis of 18-22 mm in diameter. In 5 (62.5%) patients circular resection with the IVC alloprosthesis was done, in 2 (25%) - circular resection, the IVC alloprosthesis and іmplantation of right and left renal veins into the prosthesis, and in 1 (12.5%) - circular resection, alloprosthesis of IVC and implantation of left renal vein into prosthesis. Results. The operation median duration have constituted 215 (160 - 320) min, while the average volume of the blood loss - 305 (250 - 500) ml. The Degree II postoperative complications in accordance to classification of Clavien-Dindo were registered in 2 (25%) patients. Pulmonary thromboembolism, venous thrombosis, thrombosis of prosthesis, as well as intraoperative or immediate postoperative lethality were not observed. In 7 (87.5%) patients a radical intervention was performed. In 3 (37.5%) patients a remote hepatic and pulmonary metastases have been developed, leading to their death in terms from 10 to 34 mo. General one-, two- and a three-ear survival have constituted 87.5, 75 and 62.5%, accordingly. Conclusion. Surgical approach of a «Chevron» type and the staged dissection of IVC guarantees an adequate visualization of its іnfra-, іnter- and suprarenal segments. The «piggyback» procedure of hepatic mobilization and Pringle maneuver constitute necessary parts on the stage of dissection in retrohepatic, infradiaphragmatic and supradiaphragmatic segments of IVC. Radical tumoral excision with the IVC prosthesis and implantation, when needed, of renal or hepatic veins - is the only one possibility for improvement of the patients' quality of life in the IVC leiomyosarcoma.
目标。提出下腔静脉平滑肌肉瘤的诊断治疗算法并将其应用于临床。材料和方法。在过去30年里,扎卡尔帕蒂亚以安德烈·诺瓦克命名的地区临床医院和扎卡尔帕蒂亚抗肿瘤中心为8名下腔静脉平滑肌肉瘤患者做了手术——7名(87.5%)女性和1名(12.5%)男性。患者年龄中位数为57岁。根据自己对主题的看法,将IVC分为肾下、肾间、肾上、肝后、肾下、膈上、心内7节段,以表征病变定位。Іntravasal肿瘤定位3例(37.5%),膜外定位1例(12.5%),混合定位4例(50%)。所有患者均采用开腹入路:1例(12.5%)患者采用中位剖腹入路,7例(87.5%)患者采用双侧“Chevron”型肋下剖腹入路。下腔静脉同种异体假体6例(75%)采用聚氟乙烯假体,2例(25%)采用直径为18-22 mm的Gore-tex假体。5例(62.5%)患者行下腔静脉同种异体假体环形切除术,2例(25%)患者行下腔静脉同种异体假体环形切除术并将左右肾静脉重新植入假体,1例(12.5%)患者行下腔静脉同种异体假体环形切除术并将左肾静脉植入假体。结果。手术中位时间为215 (160 ~ 320)min,平均出血量为305 (250 ~ 500)ml。2例(25%)患者出现Clavien-Dindo分级II级术后并发症。无肺血栓栓塞、静脉血栓形成、假体血栓形成、术中或术后立即死亡。7例(87.5%)患者接受根治性干预。3例(37.5%)患者发生远处肝和肺转移,死亡时间从10个月到34个月不等。因此,一般1年、2年和3年生存率分别为87.5%、75%和62.5%。结论。“雪佛龙”型手术入路和分阶段的下腔静脉解剖保证了其肾外段、肾内段和肾上段的充分可视化。肝动员的“背驮式”手术和Pringle手法是下腔静脉肝后段、膈下段和膈上段解剖阶段的必要部分。根治性肿瘤切除并植入下腔静脉假体,必要时植入肾静脉或肝静脉,是改善下腔静脉平滑肌肉瘤患者生活质量的唯一可能。
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引用次数: 0
Gastric duplication cyst 胃重复囊肿
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.9-10.99
A. Lavryk, O. Dmytrenko, V. О. Кropelnytskyi, G. М. Lytvynchuk
Gastric duplication cyst
胃重复囊肿
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引用次数: 0
The gun-shot woundings of large bowel as a predictor of severe course of fighting abdominal trauma 大肠枪伤可作为严重腹部创伤的预测指标
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.7-8.39
І. A. Lurin, K. Gumeniuk, O. B. Tymchuk, O. Popova
Objective. Analysis of experience of the medical help delivery to the wounded persons, suffering a gun-shot fighting abdominal trauma and treated in Military–Medical Clinical Centre of Eastern Region, determining a further steps, concerning optimization of the treatment-diagnosis measures in this category of patients. Materials and methods. Medical cards of 27 stationary patients with a gun-shot penetrating woundings of abdominal cavity, who were operated on the first stage in mobile hospitals with further transportation to Military–Medical Clinical Centre of Eastern Region, were studied. Concerning the missile characteristic, causing the wounding, there were 20 fragmentation woundings (іsolated – 2, multiple – 5, combined – 13), the bullet – 7 (іsolated – 1, multiple – 3, combined – 3). There were also 7 thoraco-abdominal woundings, of them 6 – the fragmentation, 1 – the bullet. In 18 patients the treatment consisted of a one-staged operative intervention performance, in 9 of them –in several stages. Among the wounded persons, who needed multi-staged treatment, 77.8% have had the large bowel damage. Results. The reoperations performance, which were more characteristic for the wounded persons with the large bowel damages, was folllowed by morbidity (adhesional ileus, peritonitis, etc.), enhancement in 2.6 times of purulent complications of postoperative wound, and in 2 times – of the average index of stationary stay, what have demanded a proportionally enhanced expenses from the health-care military system. Conclusion. Among the gun-shot penetrating woundings of abdominal cavity the multiple and combined fragmentation woundings prevailed. As a result, a statistically significant association between damages of large bowel and enhancement of prediction for the morbidity development and the treatment duration was established, using the method of correlation-regression analysis. The large bowel woundings constitute a predictor of more severe course of fighting abdominal trauma and development of complications, what leads to necessity for elaboration of differentiated approach to operative treatment of this wounded persons’ category with objective to reduce a stationary stay and possibility of the morbidity development.
目标。分析了向东部地区军事医疗临床中心治疗的枪伤腹部创伤伤员提供医疗救助的经验,确定了进一步优化这类病人的治疗诊断措施的步骤。材料和方法。研究了27名腹腔穿透枪伤的固定病人的医疗卡,这些病人在流动医院的第一阶段进行手术,然后再转运到东部地区军事医疗临床中心。导弹特性方面,造成伤的破片伤20处(单独- 2,多发- 5,联合- 13),子弹伤7处(单独- 1,多发- 3,联合- 3),胸腹伤7处,其中破片伤6处,子弹伤1处。在18例患者中,治疗包括一个阶段的手术干预表现,其中9例在几个阶段。在需要多阶段治疗的伤员中,77.8%发生了大肠损伤。结果。再手术表现以大肠损伤伤员为特征,其次是粘连性肠梗阻、腹膜炎等并发症,术后伤口化脓性并发症增加2.6倍,平均住院指数增加2倍,这就要求军队卫生保健系统按比例增加费用。结论。在腹腔穿透伤中以多发和复合破片伤为主。结果,采用相关回归分析的方法,建立了大肠损伤与发病率发展和治疗时间预测增强之间的统计学显著相关。大肠损伤是腹部创伤和并发症发展的一个更严重的过程的预测因素,这导致有必要对这类伤员的手术治疗采取不同的方法,目的是减少固定的停留和发病率发展的可能性。
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引用次数: 4
Tubular adenoma of the small intestine 小肠管状腺瘤
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.9-10.102
V. Liakhovskyi, A. V. Sydorenko, I. Nemchenko, T. V. Gorodova-Andreeva, P. V. Savchuk, D. D. Furman
Tubular adenoma of the small intestine
小肠管状腺瘤
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引用次数: 0
Preoperative biliary decompression in patients, suffering tumorogenic obturation jaundice, complicated by cholangitis, and its impact on development of postoperative complications 术前胆道减压患者,患肿瘤源性闭塞性黄疸,并发胆管炎,及其对术后并发症发展的影响
Pub Date : 2021-11-28 DOI: 10.26779/2522-1396.2021.9-10.03
O. Dronov, L. Levchenko
Objective.To estimate the impact of preoperative biliary decompression inpatients, suffering tumorogenic obturation jaundice, complicated by ascending cholangitis, on development of postoperative complications. Materials and methods. The one-centre retrospective investigation of the treatment results was conducted in 136 patients, suffering tumorogenic obturation jaundice. In 84 patients preoperative biliary decompression was done (Group I). In 52 patients preoperative biliary decompression was not performed (Group II).In all the Group I patients an ascending preoperative cholangitis was diagnosed: in 48 (57.1%) -of the I degree severity, in 36 (42.9%) - of the II degree of severity. In 21 (40.4%) patients of Group II preoperative ascending cholangitis I degree of severity was revealed. Results. Performance of preoperative biliary decompression did not worsen postoperative results, taking into account the postoperative complications structure (p=0.07), but influenced the wound infection development (p=0.01). Additional factors were determined: preoperative ascending cholangitis of I degree (p=0.007) and II degree (p=0.001) of severity; hyperbilirubinemia over 250 mcmol/l (p= 0.03); delay in operative treatment more than by 3 weeks after preoperative biliary decompression (р= 0.02); presence of the antibioticoresistant microflora in a time of preoperative biliary decompression (p=0.009) and at the operation time (p=0.002). Conclusion. Performance of preoperative biliary decompression raises the risk for the wound infection development, but is not the cause for postoperative prognosis worsening, taking into account the postoperative complications structure.
目标。目的:评估合并上行胆管炎的肿瘤源性闭合性黄疸患者术前胆道减压对术后并发症发生的影响。材料和方法。对136例肿瘤源性闭合性黄疸患者的治疗效果进行了单中心回顾性调查。84例患者术前行胆道减压术(I组),52例患者术前未行胆道减压术(II组)。所有I组患者术前均诊断为上升型胆管炎:48例(57.1%)为I级严重程度,36例(42.9%)为II级严重程度。II组上升胆管炎21例(40.4%)术前显示严重程度为I级。结果。考虑到术后并发症结构,术前胆道减压的实施并未影响术后效果(p=0.07),但影响创面感染的发生(p=0.01)。确定其他因素:术前上行胆管炎严重程度为I级(p=0.007)和II级(p=0.001);高胆红素血症> 250 McMol /l (p= 0.03);术前胆道减压术后延迟手术治疗超过3周(p < 0.05);术前胆道减压时(p=0.009)和手术时(p=0.002)耐药菌群的存在。结论。术前进行胆道减压会增加创面感染发生的风险,但考虑到术后并发症的结构,并不是导致术后预后恶化的原因。
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引用次数: 1
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Klinicheskaia khirurgiia
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