Poly ( N - isopropylacrylamide ) ( PNIPAM ) as a representative water - soluble thermo - responsive polymer exhibits a coil - to - globule phase transition followed by phase separation upon temperature increase, leading to the formation of polymer - rich domains in solution. Quantitative analysis of polymer concentration in polymer - rich domains is a challenging task for deeper understanding of the phenomena. Recently, we developed an analytical technique that combined optical tweezers with confocal Raman microspectroscopy to determine the concentration in the domain. Furthermore, optical tweezers enhanced by localized surface plasmon formed a micro - assembly of PNIPAM on plasmonic nanostructures, providing the platform for a highly sensitive detection technique for fl uorescent and non fl uorescent organic molecules dissolved in an aqueous solution. These trapping method combined with microspectroscopies are applicable for a variety of other thermos - responsive polymers.
{"title":"Raman Microspectroscopic Studies on Thermo-Responsive Polymer Rich Domains Formed by Optical Tweezers","authors":"T. Shoji, Yasuyuki Tsuboi","doi":"10.1295/KORON.2017-0087","DOIUrl":"https://doi.org/10.1295/KORON.2017-0087","url":null,"abstract":"Poly ( N - isopropylacrylamide ) ( PNIPAM ) as a representative water - soluble thermo - responsive polymer exhibits a coil - to - globule phase transition followed by phase separation upon temperature increase, leading to the formation of polymer - rich domains in solution. Quantitative analysis of polymer concentration in polymer - rich domains is a challenging task for deeper understanding of the phenomena. Recently, we developed an analytical technique that combined optical tweezers with confocal Raman microspectroscopy to determine the concentration in the domain. Furthermore, optical tweezers enhanced by localized surface plasmon formed a micro - assembly of PNIPAM on plasmonic nanostructures, providing the platform for a highly sensitive detection technique for fl uorescent and non fl uorescent organic molecules dissolved in an aqueous solution. These trapping method combined with microspectroscopies are applicable for a variety of other thermos - responsive polymers.","PeriodicalId":17878,"journal":{"name":"Kobunshi Ronbunshu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90349984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design of Self-Assembling 2,5-Diketopiperadine for Antibacterial Surface","authors":"Eri Nakatsuka, S. Kakinoki, Y. Hirano","doi":"10.1295/KORON.2017-0058","DOIUrl":"https://doi.org/10.1295/KORON.2017-0058","url":null,"abstract":"","PeriodicalId":17878,"journal":{"name":"Kobunshi Ronbunshu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89667457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tsuyoshi Kimura, N. Nakamura, Y. Hashimoto, S. Sakaguchi, S. Kimura, A. Kishida
{"title":"Selective cell capture and release using antibody-immobilized polymer-grafted surface","authors":"Tsuyoshi Kimura, N. Nakamura, Y. Hashimoto, S. Sakaguchi, S. Kimura, A. Kishida","doi":"10.1295/KORON.2017-0074","DOIUrl":"https://doi.org/10.1295/KORON.2017-0074","url":null,"abstract":"","PeriodicalId":17878,"journal":{"name":"Kobunshi Ronbunshu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83808246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design of functional thermoresponsive polymer brushes and their application to bioseparation","authors":"K. Nagase, T. Okano, H. Kanazawa","doi":"10.1295/KORON.2017-0073","DOIUrl":"https://doi.org/10.1295/KORON.2017-0073","url":null,"abstract":"","PeriodicalId":17878,"journal":{"name":"Kobunshi Ronbunshu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82560665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tsubasa Yamanouchi, N. Katsuyama, Y. Hiruta, E. Ayano, H. Kanazawa
{"title":"Development of nanocarriers functionalized with stimuli-responsive polymer for controlled cellular uptake","authors":"Tsubasa Yamanouchi, N. Katsuyama, Y. Hiruta, E. Ayano, H. Kanazawa","doi":"10.1295/KORON.2017-0064","DOIUrl":"https://doi.org/10.1295/KORON.2017-0064","url":null,"abstract":"","PeriodicalId":17878,"journal":{"name":"Kobunshi Ronbunshu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89438592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design and Application of Cell Glue","authors":"Y. Teramura","doi":"10.1295/KORON.2017-0052","DOIUrl":"https://doi.org/10.1295/KORON.2017-0052","url":null,"abstract":"","PeriodicalId":17878,"journal":{"name":"Kobunshi Ronbunshu","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90581265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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