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Evaluation of Lower Urinary Tract Symptoms suggestive of Benign Enlargement of the Prostate by Uroflowmetry and American Urological Association Symptom Score 用尿流法和美国泌尿学会症状评分评价提示前列腺良性增大的下尿路症状
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59881
A. Mallik, Md Mostafizur Rahman, Uttam Karmaker, T. Jahan, Simanta Saha, R. Begum, Marufur Rahman
Background: Uroflowmetry study is a non-invasive, simple, and inexpensive preliminary the diagnostic tool of various lower urinary tract diseases like benign prostatic hyperplasia, stricture the urethra, neurogenic bladder, etc. American Urological Association Symptom Score is the single a most important tool used in the evaluation of patients with Benign prostatic hyperplasia (BPH) and is recommended for all patients before initiation of therapy.Objectives: To evaluate lower urinary tract symptoms suggestive of Benign Enlargement of Prostate by Uroflowmetry study, measuring American Urological Symptom Score, Quality of life, and to find out correlation among Uroflowmetry parameters, age.Materials and Methods: This is a prospective study to evaluate 13 patients with lower urinary tract symptoms suggestive of benign enlargement of the prostate by performing a Uroflowmetry test. We also measured the level of symptoms by American Urological Association Symptom Score and quality of life of age group 48 to 71 years. Selected patients have gone under Uroflowmetry study recorded American Urological Association Symptom Score and quality of life by few questionnaires.Results: The mean age of the patients was 58.92+/-6.93 SD year. The mean maximum flow rate and average flow rate were found to be 16.44 and 6.99 ml/sec respectively. Voiding time and voided volume of urine was 74.53+/-44.94 SD sec, and 412.38+/- 255.66 SD ml respectively. The maximum flow rate and age were negatively correlated(R=-0.551). Time of maximum flow rate and amount of voided urine was strong positively correlated(R=0.8717, p<0.05). Voiding time and voided volume were positively correlated (p<0.05).Regarding American Urological Association Symptom Score, 53.85% of patients had severe symptoms. The mean American Urological Association Symptom Score of severe and moderate symptomatic patients were 25.14+/-3.48 SD, and 14.67+/-3.77 SD respectively. For patients of Uroflowmetry studied, 76.92% had prolonged voiding time, and 23% had normal voiding time in comparison with a normal nomogram.14Conclusions: The uroflowmetry test and American Urological Association Symptom Score are helpful for preliminary evaluation of lower urinary tract symptoms suggestive of benign enlargement of the prostate and for further treatment. Prolong voiding time and decrease maximum flow rate can give clues for outflow obstruction for benign enlargement of the prostate.KYAMC Journal Vol. 13, No. 01, April 2022: 45-49
背景:尿流法研究是一种无创、简单、廉价的下尿路疾病如良性前列腺增生、尿道狭窄、神经源性膀胱等的初步诊断工具。美国泌尿学会症状评分是评估良性前列腺增生(BPH)患者最重要的工具,建议所有患者在开始治疗前进行评分。目的:通过尿流法研究、美国泌尿学症状评分、生活质量评价提示前列腺良性增大的下尿路症状,并探讨尿流法参数与年龄的相关性。材料和方法:这是一项前瞻性研究,通过尿流法检查评估13例提示前列腺良性肿大的下尿路症状的患者。我们还采用美国泌尿协会症状评分和48 ~ 71岁年龄组的生活质量来测量症状水平。选取患者行尿流仪研究,用少量问卷记录美国泌尿学会症状评分和生活质量。结果:患者平均年龄58.92+/-6.93 SD年。平均最大流速为16.44 ml/s,平均流速为6.99 ml/s。排尿时间为74.53+/-44.94 SD sec,排尿量为412.38+/- 255.66 SD ml。最大流量与年龄呈负相关(R=-0.551)。最大尿流量时间与排尿量呈正相关(R=0.8717, p<0.05)。排尿时间与排尿量呈正相关(p<0.05)。在美国泌尿协会症状评分中,53.85%的患者有严重症状。重度和中度症状患者的平均American Urological Association Symptom Score分别为25.14+/-3.48 SD和14.67+/-3.77 SD。在尿流术研究的患者中,76.92%的患者排尿时间延长,23%的患者排尿时间正常。14结论:尿流量测定和美国泌尿协会症状评分有助于初步评估提示前列腺良性肿大的下尿路症状和进一步治疗。延长排尿时间,降低排尿最大流速,可提示良性前列腺增生的流出物梗阻。KYAMC学报第13卷第01期,2022年4月:45-49
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引用次数: 0
Effect of Zinc Supplementation on Depression in Selective Serotonin Reuptake Inhibitors-Treated Major Depressive Disorder Patients 补锌对选择性血清素再摄取抑制剂治疗的重度抑郁症患者抑郁的影响
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59876
Satabdi Ghosh, U. Ghosh, Manmun Ghosh, Akm Shahidur Rahman, Z. F. Dewan
Background: Major Depressive Disorder (MDD) is a major health problem. In Bangladesh, the prevalence of depressive disorder is 4.1%. MDD is the second cause of disability and therefore, alerts physicians of clinical psychiatry. Antidepressants are the treatment of depression. Administration of zinc indicates an important role in mood and depression.Objective: To investigate the role of zinc in MDD.Materials and Methods: A randomized controlled trial; done in the Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2019 to August 2020. Placebo group with SSRI was group ‘A’ (n =35) and zinc supplementation with Selective serotonin reuptake inhibitors (SSRIs) was group ‘B’ (n=38) for 8 weeks. A baseline visit and a follow-up visit were given after 8 weeks. Then; the severity of depression and serum zinc level was assessed.Results: After 8 weeks, the Depression, Anxiety and Stress Scale (DASS-21) score was found 11.77 ± 4.08 SD and 8.53 ± 4.38 SD in placebo and intervention group respectively. Percentage of decreased DASS-21 score was found 37.68 ± 21.47 SD and 54.48 ± 21.94 SD in placebo and intervention groups respectively. The DASS-21 score was statistically significant. The more significant reduction of DASS-21 score after zinc administration. After 8 weeks, serum zinc levels were found 0.69 ± 0.10 SD in the placebo group and 0.78 ± 0.12 SD in the intervention group. The percentage of changes in the serum zinc level in the placebo group was 0.19 ± 16.17 and in the intervention group 5.88 ± 18.39. The serum zinc levels were significant within the intervention groups. The significant elevation of serum zinc levels after 8 weeks of zinc administration in the intervention group.Conclusion: Zinc supplementation along with SSRI in MDD patients significantly ameliorated the severity of depression.KYAMC Journal Vol. 13, No. 01, April 2022: 18-23
背景:重度抑郁障碍(MDD)是一种严重的健康问题。在孟加拉国,抑郁症的患病率为4.1%。重度抑郁症是导致残疾的第二大原因,因此引起临床精神病学医生的注意。抗抑郁药是治疗抑郁症的药物。锌的服用对情绪和抑郁有重要作用。目的:探讨锌在重度抑郁症中的作用。材料与方法:随机对照试验;于2019年3月至2020年8月在Bangabandhu Sheikh Mujib医科大学(BSMMU)药学系完成。安慰剂组加SSRI为A组(n= 35),补锌组加选择性血清素再摄取抑制剂(SSRIs)为B组(n=38),疗程8周。8周后进行基线随访和随访。然后;评估抑郁严重程度和血清锌水平。结果:8周后,安慰剂组抑郁、焦虑和压力量表(DASS-21)评分为11.77±4.08 SD,干预组为8.53±4.38 SD。安慰剂组和干预组DASS-21评分下降百分率分别为37.68±21.47 SD和54.48±21.94 SD。DASS-21评分差异有统计学意义。给锌后DASS-21评分降低更为显著。8周后,安慰剂组血清锌水平为0.69±0.10 SD,干预组为0.78±0.12 SD。安慰剂组血清锌水平变化百分率为0.19±16.17,干预组为5.88±18.39。干预组血清锌水平差异有统计学意义。干预组服用锌8周后血清锌水平显著升高。结论:锌补充剂联合SSRI可显著改善重度抑郁症患者的抑郁严重程度。KYAMC学报第13卷第01期,2022年4月:18-23
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引用次数: 0
Bangla Version of the Boston Carpal Tunnel Questionnaire: Translation, Cross-Cultural Adaptation, Validation and Reliability Assessment 孟加拉语版波士顿腕管问卷:翻译、跨文化适应、验证与信度评估
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59877
Md. Israt Hasan, M. Emran, Md Atiquzzaman, Taufiq Morshed, S. M. Ahmed, Asm Mainul Hasan, Z. Chowdhury
Background: Self-reported instruments are outstanding predictor of symptom severity and functional status, hence represent a patient’s view and capture the full extent of disability. The Boston Carpal Tunnel Questionnaire (BCTQ) is a patient reported self-assessment tool for the peoples with Carpal Tunnel Syndrome (CTS).Objective: Our intension was to develop a reliable, validated and culturally adapted Bangla version of original BCTQ (B-BCTQ).Materials and Methods: The B-BCTQ was succeeded following a structured process that included translation, verification, compromise assessment, reverse translation, feedback, and final correction. B-BCTQ reliability and validity were conducted in 48 CTS patients. The reliability was evaluated by performing internal consistency and test–retest analyses. Its validity was assessed by comparing the B-BCTQ with the Physical functioning subscale (PF-10) of Short Form health Survey (SF-36) scale.Results: Cronbach’s alpha was 0.89 for symptom severity scale (SSS) and 0.86 for functional status scale (FSS). Also, Intra-class Correlation Coefficients (ICCs) were calculated as 0.86 for SSS and 0.91 for FSS. Pearson correlation (0.80 for SSS and 0.83 for FSS) analysis demonstrated that the B-BCTQ score was significantly correlated with the PF-10 of SF-36. All of the items were statistically significant (P<0.001).Conclusion: The B-BCTQ is successfully adapted. The study findings support the previous English version indicating its validity and reliability.KYAMC Journal Vol. 13, No. 01, April 2022: 24-31
背景:自我报告的工具是症状严重程度和功能状态的杰出预测器,因此代表了患者的观点并捕获了残疾的全部程度。波士顿腕管问卷(BCTQ)是一种针对腕管综合征(CTS)患者的自我评估工具。目的:我们的目的是开发一个可靠的,有效的和文化适应的孟加拉语版本的原始BCTQ (B-BCTQ)。材料和方法:B-BCTQ通过了一个结构化的过程,包括翻译、验证、折衷评估、反向翻译、反馈和最终更正。对48例CTS患者进行B-BCTQ信度和效度分析。通过进行内部一致性和重测分析来评估信度。通过比较B-BCTQ与SF-36的身体功能量表(PF-10)来评估其效度。结果:症状严重程度量表(SSS)的Cronbach’s alpha为0.89,功能状态量表(FSS)的Cronbach’s alpha为0.86。此外,类内相关系数(ICCs)计算为0.86的SSS和0.91的FSS。Pearson相关(SSS为0.80,FSS为0.83)分析表明,B-BCTQ评分与SF-36的PF-10显著相关。所有项目均有统计学意义(P<0.001)。结论:B-BCTQ适应成功。本研究结果支持先前的英文版本,显示其效度和信度。KYAMC学报第13卷第01期,2022年4月:24-31
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引用次数: 1
Pattern of Road Traffic Accident Cases Attending in the Emergency Department of Khwaja Yunus Ali Medical College and Hospital, Bangladesh. 孟加拉国赫瓦贾尤努斯阿里医学院和医院急诊科的道路交通事故病例模式。
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59880
L. Yesmin, Md Rafiqul Islam, Taslima Akber Happy, Eleza Ali, Farzana Ahmed, Debasish Ghosh, Ayesha Yasmin
Objective: To evaluate the pattern of Road Traffic Accident cases attending the Emergency Department of Khwaja Yunus Ali Medical College & Hospital (KYAMCH), Enayetpur, Sirajganj.Materials and Methods: This cross-sectional study was carried out at the emergency department of Khwaja Yunus Ali Medical College and hospital (KYAMCH), Enayetpur, Sirajganj from January’21 to June’21. Total 148 Road Traffic Accident (RTA) cases were collected by using a pre-designed format from the Emergency register/ records book, for the study.Results: During the study majority of the cases (73.65 %) were male and 58 (39.19%) of the patients belong to above 40 years of age, In the above 40 age group (29.73%) were male and (9.45%) were female. The majority (29.05%) had only soft tissue injury (Abrasion/Bruise/Laceration), followed by (27.02%) had only lower limb fracture and dislocation, (17.58%) of patient had only upper limb Fracture and dislocation,( 19.59%) had head injury,( 4.05%) had both upper and lower limb fracture, only (1.35%) had spinal cord injury and (1.35%) had another injury. During the accident common vehicle for the accident was Compressed Natural Gas (CNG) Auto-rickshaw (28.38%) followed by Motorcycle were (22.97%), 15.54% cases were due to Auto rickshaw/ van, 8.78% were due to Bi-cycle, 9.46% others. Besides that, management was given according to requirements where surgical intervention required in most of the cases, 64.87%, whereas Intensive care unit (ICU) support was required only 6.08 % cases, referred cases 8.11%, Patient refused to take treatment 10.13% cases.Conclusion: From our study we can say that, soft tissue injury (Abrasion/ Bruise/ Laceration) was a common injury found in road traffic accident patients, where CNG Auto-rickshaw and Motorcycle was the prominent source of road accident at this area, may be due to these are the main transportation in this rural area. Moreover, the recommendations from the world report on road traffic injury prevention should be considered and promptly implemented. The awareness among both users of road and administrators about road travel discipline should be very high in order to curb the ever-rising epidemic of road traffic accidents.KYAMC Journal Vol. 13, No. 01, April 2022: 41-44
目的:评价西拉甘省埃纳耶特普尔市赫瓦贾尤努斯阿里医学院急诊科道路交通事故病例的分布情况。材料和方法:本横断面研究于21年1月至21年6月在Sirajganj Enayetpur的Khwaja Yunus Ali医学院和医院(KYAMCH)的急诊科进行。使用预先设计的格式从紧急登记册/记录簿中收集了148个道路交通事故(RTA)案例,用于研究。结果:本组病例中男性占73.65%,40岁以上58例(39.19%),其中40岁以上年龄组男性占29.73%,女性占9.45%。仅软组织损伤(擦伤/瘀伤/撕裂伤)占多数(29.05%),其次为仅下肢骨折脱位(27.02%),仅上肢骨折脱位(17.58%),头部损伤(19.59%),上肢和下肢同时骨折(4.05%),脊髓损伤(1.35%)和其他损伤(1.35%)。事故中最常见的交通工具是压缩天然气(CNG)机动三轮车(28.38%),其次是摩托车(22.97%),机动三轮车/货车占15.54%,自行车占8.78%,其他占9.46%。此外,大多数病例(64.87%)按要求进行了手术治疗,而重症监护病房(ICU)支持仅占6.08%,转介病例8.11%,患者拒绝治疗10.13%。结论:软组织损伤(擦伤/瘀伤/撕裂伤)是道路交通事故患者中常见的损伤,其中CNG机动三轮车和摩托车是该地区道路交通事故的主要来源,这可能是由于这些交通工具是该农村地区的主要交通工具。此外,应审议和迅速执行《世界预防道路交通伤害报告》的建议。为了遏制日益严重的道路交通事故,道路使用者和管理者都应该提高道路交通纪律意识。KYAMC学报第13卷第01期,2022年4月:41-44
{"title":"Pattern of Road Traffic Accident Cases Attending in the Emergency Department of Khwaja Yunus Ali Medical College and Hospital, Bangladesh.","authors":"L. Yesmin, Md Rafiqul Islam, Taslima Akber Happy, Eleza Ali, Farzana Ahmed, Debasish Ghosh, Ayesha Yasmin","doi":"10.3329/kyamcj.v13i1.59880","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59880","url":null,"abstract":"Objective: To evaluate the pattern of Road Traffic Accident cases attending the Emergency Department of Khwaja Yunus Ali Medical College & Hospital (KYAMCH), Enayetpur, Sirajganj.\u0000Materials and Methods: This cross-sectional study was carried out at the emergency department of Khwaja Yunus Ali Medical College and hospital (KYAMCH), Enayetpur, Sirajganj from January’21 to June’21. Total 148 Road Traffic Accident (RTA) cases were collected by using a pre-designed format from the Emergency register/ records book, for the study.\u0000Results: During the study majority of the cases (73.65 %) were male and 58 (39.19%) of the patients belong to above 40 years of age, In the above 40 age group (29.73%) were male and (9.45%) were female. The majority (29.05%) had only soft tissue injury (Abrasion/Bruise/Laceration), followed by (27.02%) had only lower limb fracture and dislocation, (17.58%) of patient had only upper limb Fracture and dislocation,( 19.59%) had head injury,( 4.05%) had both upper and lower limb fracture, only (1.35%) had spinal cord injury and (1.35%) had another injury. During the accident common vehicle for the accident was Compressed Natural Gas (CNG) Auto-rickshaw (28.38%) followed by Motorcycle were (22.97%), 15.54% cases were due to Auto rickshaw/ van, 8.78% were due to Bi-cycle, 9.46% others. Besides that, management was given according to requirements where surgical intervention required in most of the cases, 64.87%, whereas Intensive care unit (ICU) support was required only 6.08 % cases, referred cases 8.11%, Patient refused to take treatment 10.13% cases.\u0000Conclusion: From our study we can say that, soft tissue injury (Abrasion/ Bruise/ Laceration) was a common injury found in road traffic accident patients, where CNG Auto-rickshaw and Motorcycle was the prominent source of road accident at this area, may be due to these are the main transportation in this rural area. Moreover, the recommendations from the world report on road traffic injury prevention should be considered and promptly implemented. The awareness among both users of road and administrators about road travel discipline should be very high in order to curb the ever-rising epidemic of road traffic accidents.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 41-44","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88115916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical Expression of Vascular Endothelial Growth Factor in Different Histomorphological Types of Breast Carcinoma. 血管内皮生长因子在不同组织形态类型乳腺癌中的免疫组织化学表达。
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59874
Shakila Jannat, Halima Khatun Doly, Mousumi Ahmed, Sifat Syeed
Background: Breast carcinoma is a heterogenous disease that represent a major health problem in Bangladeshi population. Several molecular markers have been detected over the past several decades, that are important in clinical aspects of breast carcinoma. Most recently, Vascular Endothelial Growth Factor (VEGF) is emerging as a prognostic marker in patients with several types of carcinoma including breast carcinoma. Many anti-angiogenic therapies targeting VEGF has been proven effective in many carcinomas.Objectives:This study was aimed to determine the expression of VEGF in different histomorphological types of breast carcinoma in an attempt to clarify its potential clinical outcome.Materials and Methods: This study was conducted in the Department of Pathology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka from March 2018 to January 2020. In this study, 45 diagnosed cases of breast carcinoma were enrolled. Histopathological slides of all cases were re-evaluated. Thin sections were taken on coated slides from each paraffin block and immunohistochemical staining was done with VEGF antibody.Results: Among 45 cases, 73.3% cases were invasive ductal carcinoma and 13.3% cases were invasive lobular carcinoma. The immunohistochemical expression of VEGF was positive in 60% cases. In this study, 100% cases of in-situ ductal carcinoma, 83.3% cases of invasive lobular carcinoma and 57.6% cases of invasive ductal carcinoma showed overexpression of VEGF. However VEGF expression did not show significant association with histomorphological types.Conclusion: VEGF expression was found in 60% of breast carcinoma cases. It may serve as a potential therapeutic target for the management of breast carcinoma.KYAMC Journal Vol. 13, No. 01, April 2022: 9-12
背景:乳腺癌是一种异质性疾病,是孟加拉国人口的一个主要健康问题。在过去的几十年里,已经发现了一些分子标记,它们在乳腺癌的临床方面很重要。最近,血管内皮生长因子(VEGF)正在成为包括乳腺癌在内的几种类型癌症患者的预后标志物。许多针对VEGF的抗血管生成疗法已被证明对许多癌症有效。目的:本研究旨在确定VEGF在不同组织形态类型乳腺癌中的表达,试图阐明其潜在的临床结果。材料与方法:本研究于2018年3月至2020年1月在达卡孟加拉国糖尿病、内分泌和代谢疾病研究与康复研究所(BIRDEM)总医院病理学系进行。本研究纳入了45例确诊的乳腺癌患者。重新评估所有病例的组织病理切片。每个石蜡块在包被玻片上取薄片,用VEGF抗体进行免疫组化染色。结果:45例患者中浸润性导管癌占73.3%,浸润性小叶癌占13.3%。60%的患者VEGF免疫组化表达阳性。在本研究中,100%的原位导管癌、83.3%的浸润性小叶癌和57.6%的浸润性导管癌均存在VEGF过表达。而VEGF表达与组织形态类型无显著相关性。结论:VEGF在60%的乳腺癌中有表达。它可能成为乳腺癌治疗的潜在治疗靶点。KYAMC学报第13卷第01期,2022年4月:9-12
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引用次数: 0
Histopathological Comparison between Punch and Full Thickness Rectal Biopsy in Diagnosis of Hirschsprung’s Disease 直肠穿刺活检与全层活检诊断巨结肠病的组织病理学比较
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59879
Halima Khatun Doly, Shakila Jannat, Afm Saleh, Shamimur Rahman, Debashish Chakraborty
Background: The diagnosis of Hirschsprung’s disease (HD) is dependent on the histological study of rectal ganglion cells. Open rectal biopsy is the mainstay that requires general anesthesia (GA) and carries risk of many complications. Rectal punch biopsy has gained wide acceptance and has become the choice as it is simple, safe, having no need of anesthesia, done bedside with a simple biopsy forcep with high degree of accuracy and virtual absence of any complications.Objective: To find out the efficacy of rectal punch biopsy in the diagnosis of Hirschsprung’s disease.Materials and Methods: A cross sectional descriptive observational study was carried out with the histological findings of 60 rectal punch biopsies with corresponding 60 full thickness rectal biopsies from 60 suspected HD patients from March 2018 to February 2020. Sections made from the paraffin blocks were stained with H&E and were examined for the presence or absence of ganglion cells and hypertrophic nerve fibers in the submucosa. Then the relations were studied. These findings were compared with full thickness rectal biopsy.Result: There were 40(66.7%) cases of male and 20(33.3%) cases of female including 26 (43.3%) cases of infants. Out of 60 cases, 10 cases (seven inadequate and three suspicious) of punch biopsy were not compared with full thickness rectal biopsy. Out of 50 cases, 38(63.3%) cases were HD in punch biopsy; among these 36(92.3%) cases were HD and 2(18.2%) cases were Non-HD in full thickness rectal tissue biopsy. The accuracy of punch biopsy was measured by sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and efficiency of the test which were 92.3%, 81.8%, 94.7%, 75.0% and 90.0% respectively.Conclusion: The rectal punch biopsy is simple, safe, no need of anesthesia and can be done with a simple biopsy forcep with high degree of accuracy.KYAMC Journal Vol. 13, No. 01, April 2022: 37-40
背景:巨结肠病的诊断依赖于直肠神经节细胞的组织学研究。直肠切开活检是需要全身麻醉(GA)的主要方法,并且有许多并发症的风险。直肠穿刺活检因其简单、安全、无需麻醉、床边活检钳简单、准确度高、几乎没有任何并发症而被广泛接受并成为首选。目的:探讨直肠穿刺活检对先天性巨结肠的诊断价值。材料与方法:对2018年3月至2020年2月60例疑似HD患者的60例直肠穿刺活检和相应的60例全层直肠活检的组织学结果进行横断面描述性观察研究。石蜡切片用H&E染色,检查粘膜下层是否有神经节细胞和肥大的神经纤维。然后研究了它们之间的关系。这些结果与全层直肠活检相比较。结果:男性40例(66.7%),女性20例(33.3%),其中婴幼儿26例(43.3%)。60例中,有10例(7例不充分,3例可疑)未与直肠全层活检进行比较。50例中,38例(63.3%)穿刺活检为HD;全层直肠组织活检显示HD 36例(92.3%),Non-HD 2例(18.2%)。以敏感度、特异度、阳性预测值(PPV)、阴性预测值(NPV)和检测效率衡量穿刺活检的准确性,分别为92.3%、81.8%、94.7%、75.0%和90.0%。结论:直肠穿刺活检简单、安全,无需麻醉,使用简便的活检钳即可完成,活检准确率高。KYAMC学报第13卷第01期,2022年4月:37-40
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引用次数: 0
Umbilical Discharge 脐放电
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59882
A. Moniruddin, H. Raihan, Mst Nazmun Nahar Khanom, Tanvirul Hasan, Ba Ferdous, M. R. Khan, M. A. Rouf
An umbilical discharge is itself not a disease, but it is a symptom of many diseases. In children, it may be found to be associated with an underlying congenital abnormality like persistent OMD (Omphalo-mesenteric Duct) or Vitelline cysts or sinuses or umbilical granuloma or a diverticulum like the Meckel’s diverticulum which may possess ectopic gastric or pancreatic or even colonic mucosa, or the persistent allantois or a urachal cyst or an infected urachus etc. Umbilical discharge though rare in adults, it may be caused by diverse congenital or acquired conditions. The most common causes of umbilical discharge in adults are such acquired conditions as pilonidal sinus disease, infection of hair tufts and foreign bodies4, and specific and non-specific acute and chronic inflammation and abscess of the umbilicus, infected omphalolith etc. Very rarely the discharge may be due to endometriosis or metastatic carcinoma, umbilical hernia ulceration etc. Discharging umbilical abscess may be caused by bacteria that can enter as a result of penetrating trauma, rupture of the bowel, or abdominal surgery. Irrespective of aetiology, umbilical discharge is a distressing condition for the patient and the family members. Appropriate diagnostic aids and successful management strategies are now available. If not associated with malignant diseases or irreversible complications, the prognosis is excellent.KYAMC Journal Vol. 13, No. 01, April 2022: 50-55
脐带出血本身不是一种疾病,但它是许多疾病的症状。在儿童中,它可能与潜在的先天性异常有关,如持续性OMD(脐-肠系膜导管)或卵黄囊肿或窦或脐肉芽肿或憩室,如Meckel憩室,可能具有异位的胃或胰腺甚至结肠粘膜,或持续性尿囊或尿管囊肿或感染的尿管等。脐部分泌物虽然在成人中很少见,但它可能由多种先天性或后天条件引起。成人脐带分泌物最常见的原因是获得性条件,如毛窦疾病、毛丛和异物感染4、特异性和非特异性急慢性炎症和脐脓肿、感染脐石等。极少因子宫内膜异位症或转移性癌、脐疝溃疡等引起。排出性脐脓肿可能是由细菌引起的,细菌可以由于穿透性创伤、肠破裂或腹部手术而进入。无论病因如何,脐带分泌物对患者及其家属来说都是一种痛苦的状况。目前已有适当的诊断辅助工具和成功的管理策略。如果不伴有恶性疾病或不可逆并发症,预后良好。KYAMC学报第13卷第01期,2022年4月:50-55
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引用次数: 0
Sepsis Profile of Neonates Admitted to Neonatal Intensive Care Unit of a Tertiary Care Hospital 某三级医院新生儿重症监护室新生儿败血症概况
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59878
U. Ghosh, Mosammat Afroza Jinnat, Imrul Kaes, Shakila Jannat, M. Solayman, Md Abdul Hadi Al Mamun
Background: Neonatal sepsis is defined as a clinical condition of bacteremia with clinical features of infection in the first 28 days of life. Neonatal sepsis is an important cause of neonatal deaths worldwide. If detected early and treated aggressively and appropriately with antibiotics with good supportive care, it can be possible to save a life.Objective: The present study is carried out to overview the clinical and investigations profile, and outcome of neonatal sepsis admitted in a neonatal intensive care unit (NICU).Materials and Methods: This is a retrospective descriptive study. This study included newborns diagnosed with neonatal sepsis admitted to the Neonatal Intensive Care Unit (NICU) of Khwaja Yunus Ali Medical College and Hospital, Sirajgonj from October 2020 to January 2022. The case records of 50 neonatal sepsis. The case records of these newborns were thoroughly studied and recorded for relevant information including detailed history including maternal, clinical evaluation, and available investigation. The outcome was also noted.Results: Among the 50 neonatal sepsis cases early-onset neonatal sepsis was 56%; where mostly preterm (74%) and low birth weight (44%). Clinical presentations were mostly reluctant to feed (70%) associated with other septic features. Septicemia only (36%), pneumonia (14%), neonatal intestinal obstruction (10%) were found as the main pattern of sepsis. Among the cases septic screening profile thrombocytopenia 84%, CRP Positive 78%, leukopenia 58%, anemia 26%, leukocytosis 22%, normal 20%, toxic granules or band form neutrophil 14%, positive blood culture 14% were found. Probable risk factors were found mainly low birth weight (78%) and prematurity (74%); overlapping with many other risk factors. Thirty-six percent were death among sepsis.Conclusion: In the neonatal intensive care unit mostly early-onset neonatal sepsis has been observed in outborn, premature, and Low Birth Weight (LBW) babies presenting with reluctance to feed with associated risk factors; where thrombocytopenia invariably found in sepsis screening and survival rate around sixty-five percentKYAMC Journal Vol. 13, No. 01, April 2022: 32-36
背景:新生儿脓毒症被定义为在出生后28天内以感染为临床特征的菌血症。新生儿败血症是全世界新生儿死亡的一个重要原因。如果及早发现并积极适当地使用抗生素进行治疗,并辅以良好的支持性护理,就有可能挽救生命。目的:本研究综述了新生儿重症监护病房(NICU)收治的新生儿脓毒症的临床、调查概况和预后。材料与方法:本研究为回顾性描述性研究。本研究纳入了2020年10月至2022年1月在Sirajgonj Khwaja Yunus Ali医学院和医院新生儿重症监护病房(NICU)确诊为新生儿败血症的新生儿。新生儿败血症50例。对这些新生儿的病例记录进行了全面的研究,并记录了相关信息,包括详细的病史,包括产妇、临床评估和现有的调查。会议还注意到结果。结果:50例新生儿败血症中,早发性新生儿败血症占56%;其中大多数是早产(74%)和低出生体重(44%)。临床表现多为不愿进食(70%)并伴有其他脓毒性特征。败血症(36%)、肺炎(14%)、新生儿肠梗阻(10%)是败血症的主要表现形式。脓毒症筛查中血小板减少84%,CRP阳性78%,白细胞减少58%,贫血26%,白细胞增多22%,正常20%,毒性颗粒或带状中性粒细胞14%,血培养阳性14%。可能的危险因素主要是低出生体重(78%)和早产(74%);与许多其他风险因素重叠。36%的人死于败血症。结论:在新生儿重症监护病房,早产和低出生体重(LBW)婴儿出现不愿进食并伴有相关危险因素,大多发生早发性新生儿脓毒症;在脓毒症筛查中发现血小板减少症患者的生存率约为65%。《amc杂志》Vol. 13, No. 01, April 2022: 32-36
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引用次数: 0
Effect of Folic Acid on Homocysteine Level in Ischemic Stroke Patients in a Tertiary Level Hospital in Rajshahi. 叶酸对拉吉沙希某三级医院缺血性脑卒中患者同型半胱氨酸水平的影响
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59875
Lotifa Haque, Md. Anwar Habib, Md. Yousuf Ali, Sonia Nilufar, Tarifat Alam, M. Hoque
Background: A number of risk factors are responsible for ischemic stroke some are modifiable and some are not modifiable. Homocysteine is a modifiable, independent risk factor of ischemic stroke.Objective: To evaluate the effectiveness of folic acid on homocysteine levels in ischemic stroke patients.Materials and Methods: This study was an experimental study carried out in the Department of Pharmacology and Therapeutics, Rajshahi Medical College in collaboration with the Department of Neurology, Rajshahi Medical College Hospital from July 2016 to June 2017. A total number of 90 ischemic stroke patients diagnosed by CT scan findings who came for treatment in the Neurology department of Rajshahi Medical College Hospital were enrolled in this study. Simple random sampling is done. The patients were divided into two groups: experimental group (45 patients) who were treated with 5mg folic acid along with other traditional treatment, control group (45 patients) who were treated by only traditional therapy given by the neurology department. Before starting treatment, along with other investigations, serum homocysteine level of both experimental and control groups was estimated. After three months of continuous treatment with folic acid in the experimental group, the serum homocysteine level of both groups was measured again. Data were analyzed using SPSS version 16 for windows.Results: The results showed that there was a small numerical difference in homocysteine level before and after treatment in the experimental and control group, yet the change was statistically significant in the experimental group after three months of treatment with 5mg folic acid.Conclusion: It is revealed that use of folic acid may play an important role in reducing homocysteine level in ischemic stroke patients.KYAMC Journal Vol. 13, No. 01, April 2022: 13-17
背景:一些危险因素是缺血性中风的原因,有些是可以改变的,有些是不可改变的。同型半胱氨酸是缺血性脑卒中可改变的独立危险因素。目的:探讨叶酸对缺血性脑卒中患者同型半胱氨酸水平的影响。材料与方法:本研究于2016年7月至2017年6月在Rajshahi医学院药理学与治疗学系与Rajshahi医学院附属医院神经内科合作开展的实验研究。本研究共纳入90例在Rajshahi医学院附属医院神经内科接受CT扫描诊断的缺血性脑卒中患者。简单随机抽样就完成了。将患者分为两组:实验组(45例)在给予5mg叶酸治疗的同时给予其他传统治疗;对照组(45例)只给予神经内科传统治疗。在开始治疗前,与其他调查一起,对实验组和对照组的血清同型半胱氨酸水平进行了估计。实验组连续给予叶酸治疗3个月后,再次测定两组血清同型半胱氨酸水平。数据分析使用SPSS version 16 for windows。结果:实验组与对照组治疗前后同型半胱氨酸水平数值差异不大,但实验组5mg叶酸治疗3个月后变化有统计学意义。结论:叶酸对降低缺血性脑卒中患者同型半胱氨酸水平有重要作用。KYAMC学报第13卷第01期,2022年4月:13-17
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引用次数: 0
Antibiotic Resistance in Bangladesh: Should Take Necessary Action Before the Situation Goes Out of Control! 孟加拉国的抗生素耐药性:在情况失控之前应该采取必要的行动!
Pub Date : 2022-06-05 DOI: 10.3329/kyamcj.v13i1.59872
Akm Shahidur Rahman
Abstract not availableKYAMC Journal Vol. 13, No. 01, April 2022: 1-3
《中华医学杂志》第13卷第01期,2022年4月:1-3
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引用次数: 0
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