Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59881
A. Mallik, Md Mostafizur Rahman, Uttam Karmaker, T. Jahan, Simanta Saha, R. Begum, Marufur Rahman
Background: Uroflowmetry study is a non-invasive, simple, and inexpensive preliminary the diagnostic tool of various lower urinary tract diseases like benign prostatic hyperplasia, stricture the urethra, neurogenic bladder, etc. American Urological Association Symptom Score is the single a most important tool used in the evaluation of patients with Benign prostatic hyperplasia (BPH) and is recommended for all patients before initiation of therapy. Objectives: To evaluate lower urinary tract symptoms suggestive of Benign Enlargement of Prostate by Uroflowmetry study, measuring American Urological Symptom Score, Quality of life, and to find out correlation among Uroflowmetry parameters, age. Materials and Methods: This is a prospective study to evaluate 13 patients with lower urinary tract symptoms suggestive of benign enlargement of the prostate by performing a Uroflowmetry test. We also measured the level of symptoms by American Urological Association Symptom Score and quality of life of age group 48 to 71 years. Selected patients have gone under Uroflowmetry study recorded American Urological Association Symptom Score and quality of life by few questionnaires. Results: The mean age of the patients was 58.92+/-6.93 SD year. The mean maximum flow rate and average flow rate were found to be 16.44 and 6.99 ml/sec respectively. Voiding time and voided volume of urine was 74.53+/-44.94 SD sec, and 412.38+/- 255.66 SD ml respectively. The maximum flow rate and age were negatively correlated(R=-0.551). Time of maximum flow rate and amount of voided urine was strong positively correlated(R=0.8717, p<0.05). Voiding time and voided volume were positively correlated (p<0.05).Regarding American Urological Association Symptom Score, 53.85% of patients had severe symptoms. The mean American Urological Association Symptom Score of severe and moderate symptomatic patients were 25.14+/-3.48 SD, and 14.67+/-3.77 SD respectively. For patients of Uroflowmetry studied, 76.92% had prolonged voiding time, and 23% had normal voiding time in comparison with a normal nomogram.14 Conclusions: The uroflowmetry test and American Urological Association Symptom Score are helpful for preliminary evaluation of lower urinary tract symptoms suggestive of benign enlargement of the prostate and for further treatment. Prolong voiding time and decrease maximum flow rate can give clues for outflow obstruction for benign enlargement of the prostate. KYAMC Journal Vol. 13, No. 01, April 2022: 45-49
{"title":"Evaluation of Lower Urinary Tract Symptoms suggestive of Benign Enlargement of the Prostate by Uroflowmetry and American Urological Association Symptom Score","authors":"A. Mallik, Md Mostafizur Rahman, Uttam Karmaker, T. Jahan, Simanta Saha, R. Begum, Marufur Rahman","doi":"10.3329/kyamcj.v13i1.59881","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59881","url":null,"abstract":"Background: Uroflowmetry study is a non-invasive, simple, and inexpensive preliminary the diagnostic tool of various lower urinary tract diseases like benign prostatic hyperplasia, stricture the urethra, neurogenic bladder, etc. American Urological Association Symptom Score is the single a most important tool used in the evaluation of patients with Benign prostatic hyperplasia (BPH) and is recommended for all patients before initiation of therapy.\u0000Objectives: To evaluate lower urinary tract symptoms suggestive of Benign Enlargement of Prostate by Uroflowmetry study, measuring American Urological Symptom Score, Quality of life, and to find out correlation among Uroflowmetry parameters, age.\u0000Materials and Methods: This is a prospective study to evaluate 13 patients with lower urinary tract symptoms suggestive of benign enlargement of the prostate by performing a Uroflowmetry test. We also measured the level of symptoms by American Urological Association Symptom Score and quality of life of age group 48 to 71 years. Selected patients have gone under Uroflowmetry study recorded American Urological Association Symptom Score and quality of life by few questionnaires.\u0000Results: The mean age of the patients was 58.92+/-6.93 SD year. The mean maximum flow rate and average flow rate were found to be 16.44 and 6.99 ml/sec respectively. Voiding time and voided volume of urine was 74.53+/-44.94 SD sec, and 412.38+/- 255.66 SD ml respectively. The maximum flow rate and age were negatively correlated(R=-0.551). Time of maximum flow rate and amount of voided urine was strong positively correlated(R=0.8717, p<0.05). Voiding time and voided volume were positively correlated (p<0.05).Regarding American Urological Association Symptom Score, 53.85% of patients had severe symptoms. The mean American Urological Association Symptom Score of severe and moderate symptomatic patients were 25.14+/-3.48 SD, and 14.67+/-3.77 SD respectively. For patients of Uroflowmetry studied, 76.92% had prolonged voiding time, and 23% had normal voiding time in comparison with a normal nomogram.14\u0000Conclusions: The uroflowmetry test and American Urological Association Symptom Score are helpful for preliminary evaluation of lower urinary tract symptoms suggestive of benign enlargement of the prostate and for further treatment. Prolong voiding time and decrease maximum flow rate can give clues for outflow obstruction for benign enlargement of the prostate.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 45-49","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85700252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59876
Satabdi Ghosh, U. Ghosh, Manmun Ghosh, Akm Shahidur Rahman, Z. F. Dewan
Background: Major Depressive Disorder (MDD) is a major health problem. In Bangladesh, the prevalence of depressive disorder is 4.1%. MDD is the second cause of disability and therefore, alerts physicians of clinical psychiatry. Antidepressants are the treatment of depression. Administration of zinc indicates an important role in mood and depression. Objective: To investigate the role of zinc in MDD. Materials and Methods: A randomized controlled trial; done in the Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2019 to August 2020. Placebo group with SSRI was group ‘A’ (n =35) and zinc supplementation with Selective serotonin reuptake inhibitors (SSRIs) was group ‘B’ (n=38) for 8 weeks. A baseline visit and a follow-up visit were given after 8 weeks. Then; the severity of depression and serum zinc level was assessed. Results: After 8 weeks, the Depression, Anxiety and Stress Scale (DASS-21) score was found 11.77 ± 4.08 SD and 8.53 ± 4.38 SD in placebo and intervention group respectively. Percentage of decreased DASS-21 score was found 37.68 ± 21.47 SD and 54.48 ± 21.94 SD in placebo and intervention groups respectively. The DASS-21 score was statistically significant. The more significant reduction of DASS-21 score after zinc administration. After 8 weeks, serum zinc levels were found 0.69 ± 0.10 SD in the placebo group and 0.78 ± 0.12 SD in the intervention group. The percentage of changes in the serum zinc level in the placebo group was 0.19 ± 16.17 and in the intervention group 5.88 ± 18.39. The serum zinc levels were significant within the intervention groups. The significant elevation of serum zinc levels after 8 weeks of zinc administration in the intervention group. Conclusion: Zinc supplementation along with SSRI in MDD patients significantly ameliorated the severity of depression. KYAMC Journal Vol. 13, No. 01, April 2022: 18-23
{"title":"Effect of Zinc Supplementation on Depression in Selective Serotonin Reuptake Inhibitors-Treated Major Depressive Disorder Patients","authors":"Satabdi Ghosh, U. Ghosh, Manmun Ghosh, Akm Shahidur Rahman, Z. F. Dewan","doi":"10.3329/kyamcj.v13i1.59876","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59876","url":null,"abstract":"Background: Major Depressive Disorder (MDD) is a major health problem. In Bangladesh, the prevalence of depressive disorder is 4.1%. MDD is the second cause of disability and therefore, alerts physicians of clinical psychiatry. Antidepressants are the treatment of depression. Administration of zinc indicates an important role in mood and depression.\u0000Objective: To investigate the role of zinc in MDD.\u0000Materials and Methods: A randomized controlled trial; done in the Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2019 to August 2020. Placebo group with SSRI was group ‘A’ (n =35) and zinc supplementation with Selective serotonin reuptake inhibitors (SSRIs) was group ‘B’ (n=38) for 8 weeks. A baseline visit and a follow-up visit were given after 8 weeks. Then; the severity of depression and serum zinc level was assessed.\u0000Results: After 8 weeks, the Depression, Anxiety and Stress Scale (DASS-21) score was found 11.77 ± 4.08 SD and 8.53 ± 4.38 SD in placebo and intervention group respectively. Percentage of decreased DASS-21 score was found 37.68 ± 21.47 SD and 54.48 ± 21.94 SD in placebo and intervention groups respectively. The DASS-21 score was statistically significant. The more significant reduction of DASS-21 score after zinc administration. After 8 weeks, serum zinc levels were found 0.69 ± 0.10 SD in the placebo group and 0.78 ± 0.12 SD in the intervention group. The percentage of changes in the serum zinc level in the placebo group was 0.19 ± 16.17 and in the intervention group 5.88 ± 18.39. The serum zinc levels were significant within the intervention groups. The significant elevation of serum zinc levels after 8 weeks of zinc administration in the intervention group.\u0000Conclusion: Zinc supplementation along with SSRI in MDD patients significantly ameliorated the severity of depression.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 18-23","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78055170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59877
Md. Israt Hasan, M. Emran, Md Atiquzzaman, Taufiq Morshed, S. M. Ahmed, Asm Mainul Hasan, Z. Chowdhury
Background: Self-reported instruments are outstanding predictor of symptom severity and functional status, hence represent a patient’s view and capture the full extent of disability. The Boston Carpal Tunnel Questionnaire (BCTQ) is a patient reported self-assessment tool for the peoples with Carpal Tunnel Syndrome (CTS). Objective: Our intension was to develop a reliable, validated and culturally adapted Bangla version of original BCTQ (B-BCTQ). Materials and Methods: The B-BCTQ was succeeded following a structured process that included translation, verification, compromise assessment, reverse translation, feedback, and final correction. B-BCTQ reliability and validity were conducted in 48 CTS patients. The reliability was evaluated by performing internal consistency and test–retest analyses. Its validity was assessed by comparing the B-BCTQ with the Physical functioning subscale (PF-10) of Short Form health Survey (SF-36) scale. Results: Cronbach’s alpha was 0.89 for symptom severity scale (SSS) and 0.86 for functional status scale (FSS). Also, Intra-class Correlation Coefficients (ICCs) were calculated as 0.86 for SSS and 0.91 for FSS. Pearson correlation (0.80 for SSS and 0.83 for FSS) analysis demonstrated that the B-BCTQ score was significantly correlated with the PF-10 of SF-36. All of the items were statistically significant (P<0.001). Conclusion: The B-BCTQ is successfully adapted. The study findings support the previous English version indicating its validity and reliability. KYAMC Journal Vol. 13, No. 01, April 2022: 24-31
{"title":"Bangla Version of the Boston Carpal Tunnel Questionnaire: Translation, Cross-Cultural Adaptation, Validation and Reliability Assessment","authors":"Md. Israt Hasan, M. Emran, Md Atiquzzaman, Taufiq Morshed, S. M. Ahmed, Asm Mainul Hasan, Z. Chowdhury","doi":"10.3329/kyamcj.v13i1.59877","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59877","url":null,"abstract":"Background: Self-reported instruments are outstanding predictor of symptom severity and functional status, hence represent a patient’s view and capture the full extent of disability. The Boston Carpal Tunnel Questionnaire (BCTQ) is a patient reported self-assessment tool for the peoples with Carpal Tunnel Syndrome (CTS).\u0000Objective: Our intension was to develop a reliable, validated and culturally adapted Bangla version of original BCTQ (B-BCTQ).\u0000Materials and Methods: The B-BCTQ was succeeded following a structured process that included translation, verification, compromise assessment, reverse translation, feedback, and final correction. B-BCTQ reliability and validity were conducted in 48 CTS patients. The reliability was evaluated by performing internal consistency and test–retest analyses. Its validity was assessed by comparing the B-BCTQ with the Physical functioning subscale (PF-10) of Short Form health Survey (SF-36) scale.\u0000Results: Cronbach’s alpha was 0.89 for symptom severity scale (SSS) and 0.86 for functional status scale (FSS). Also, Intra-class Correlation Coefficients (ICCs) were calculated as 0.86 for SSS and 0.91 for FSS. Pearson correlation (0.80 for SSS and 0.83 for FSS) analysis demonstrated that the B-BCTQ score was significantly correlated with the PF-10 of SF-36. All of the items were statistically significant (P<0.001).\u0000Conclusion: The B-BCTQ is successfully adapted. The study findings support the previous English version indicating its validity and reliability.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 24-31","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80805405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the pattern of Road Traffic Accident cases attending the Emergency Department of Khwaja Yunus Ali Medical College & Hospital (KYAMCH), Enayetpur, Sirajganj. Materials and Methods: This cross-sectional study was carried out at the emergency department of Khwaja Yunus Ali Medical College and hospital (KYAMCH), Enayetpur, Sirajganj from January’21 to June’21. Total 148 Road Traffic Accident (RTA) cases were collected by using a pre-designed format from the Emergency register/ records book, for the study. Results: During the study majority of the cases (73.65 %) were male and 58 (39.19%) of the patients belong to above 40 years of age, In the above 40 age group (29.73%) were male and (9.45%) were female. The majority (29.05%) had only soft tissue injury (Abrasion/Bruise/Laceration), followed by (27.02%) had only lower limb fracture and dislocation, (17.58%) of patient had only upper limb Fracture and dislocation,( 19.59%) had head injury,( 4.05%) had both upper and lower limb fracture, only (1.35%) had spinal cord injury and (1.35%) had another injury. During the accident common vehicle for the accident was Compressed Natural Gas (CNG) Auto-rickshaw (28.38%) followed by Motorcycle were (22.97%), 15.54% cases were due to Auto rickshaw/ van, 8.78% were due to Bi-cycle, 9.46% others. Besides that, management was given according to requirements where surgical intervention required in most of the cases, 64.87%, whereas Intensive care unit (ICU) support was required only 6.08 % cases, referred cases 8.11%, Patient refused to take treatment 10.13% cases. Conclusion: From our study we can say that, soft tissue injury (Abrasion/ Bruise/ Laceration) was a common injury found in road traffic accident patients, where CNG Auto-rickshaw and Motorcycle was the prominent source of road accident at this area, may be due to these are the main transportation in this rural area. Moreover, the recommendations from the world report on road traffic injury prevention should be considered and promptly implemented. The awareness among both users of road and administrators about road travel discipline should be very high in order to curb the ever-rising epidemic of road traffic accidents. KYAMC Journal Vol. 13, No. 01, April 2022: 41-44
{"title":"Pattern of Road Traffic Accident Cases Attending in the Emergency Department of Khwaja Yunus Ali Medical College and Hospital, Bangladesh.","authors":"L. Yesmin, Md Rafiqul Islam, Taslima Akber Happy, Eleza Ali, Farzana Ahmed, Debasish Ghosh, Ayesha Yasmin","doi":"10.3329/kyamcj.v13i1.59880","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59880","url":null,"abstract":"Objective: To evaluate the pattern of Road Traffic Accident cases attending the Emergency Department of Khwaja Yunus Ali Medical College & Hospital (KYAMCH), Enayetpur, Sirajganj.\u0000Materials and Methods: This cross-sectional study was carried out at the emergency department of Khwaja Yunus Ali Medical College and hospital (KYAMCH), Enayetpur, Sirajganj from January’21 to June’21. Total 148 Road Traffic Accident (RTA) cases were collected by using a pre-designed format from the Emergency register/ records book, for the study.\u0000Results: During the study majority of the cases (73.65 %) were male and 58 (39.19%) of the patients belong to above 40 years of age, In the above 40 age group (29.73%) were male and (9.45%) were female. The majority (29.05%) had only soft tissue injury (Abrasion/Bruise/Laceration), followed by (27.02%) had only lower limb fracture and dislocation, (17.58%) of patient had only upper limb Fracture and dislocation,( 19.59%) had head injury,( 4.05%) had both upper and lower limb fracture, only (1.35%) had spinal cord injury and (1.35%) had another injury. During the accident common vehicle for the accident was Compressed Natural Gas (CNG) Auto-rickshaw (28.38%) followed by Motorcycle were (22.97%), 15.54% cases were due to Auto rickshaw/ van, 8.78% were due to Bi-cycle, 9.46% others. Besides that, management was given according to requirements where surgical intervention required in most of the cases, 64.87%, whereas Intensive care unit (ICU) support was required only 6.08 % cases, referred cases 8.11%, Patient refused to take treatment 10.13% cases.\u0000Conclusion: From our study we can say that, soft tissue injury (Abrasion/ Bruise/ Laceration) was a common injury found in road traffic accident patients, where CNG Auto-rickshaw and Motorcycle was the prominent source of road accident at this area, may be due to these are the main transportation in this rural area. Moreover, the recommendations from the world report on road traffic injury prevention should be considered and promptly implemented. The awareness among both users of road and administrators about road travel discipline should be very high in order to curb the ever-rising epidemic of road traffic accidents.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 41-44","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88115916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59874
Shakila Jannat, Halima Khatun Doly, Mousumi Ahmed, Sifat Syeed
Background: Breast carcinoma is a heterogenous disease that represent a major health problem in Bangladeshi population. Several molecular markers have been detected over the past several decades, that are important in clinical aspects of breast carcinoma. Most recently, Vascular Endothelial Growth Factor (VEGF) is emerging as a prognostic marker in patients with several types of carcinoma including breast carcinoma. Many anti-angiogenic therapies targeting VEGF has been proven effective in many carcinomas. Objectives:This study was aimed to determine the expression of VEGF in different histomorphological types of breast carcinoma in an attempt to clarify its potential clinical outcome. Materials and Methods: This study was conducted in the Department of Pathology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka from March 2018 to January 2020. In this study, 45 diagnosed cases of breast carcinoma were enrolled. Histopathological slides of all cases were re-evaluated. Thin sections were taken on coated slides from each paraffin block and immunohistochemical staining was done with VEGF antibody. Results: Among 45 cases, 73.3% cases were invasive ductal carcinoma and 13.3% cases were invasive lobular carcinoma. The immunohistochemical expression of VEGF was positive in 60% cases. In this study, 100% cases of in-situ ductal carcinoma, 83.3% cases of invasive lobular carcinoma and 57.6% cases of invasive ductal carcinoma showed overexpression of VEGF. However VEGF expression did not show significant association with histomorphological types. Conclusion: VEGF expression was found in 60% of breast carcinoma cases. It may serve as a potential therapeutic target for the management of breast carcinoma. KYAMC Journal Vol. 13, No. 01, April 2022: 9-12
{"title":"Immunohistochemical Expression of Vascular Endothelial Growth Factor in Different Histomorphological Types of Breast Carcinoma.","authors":"Shakila Jannat, Halima Khatun Doly, Mousumi Ahmed, Sifat Syeed","doi":"10.3329/kyamcj.v13i1.59874","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59874","url":null,"abstract":"Background: Breast carcinoma is a heterogenous disease that represent a major health problem in Bangladeshi population. Several molecular markers have been detected over the past several decades, that are important in clinical aspects of breast carcinoma. Most recently, Vascular Endothelial Growth Factor (VEGF) is emerging as a prognostic marker in patients with several types of carcinoma including breast carcinoma. Many anti-angiogenic therapies targeting VEGF has been proven effective in many carcinomas.\u0000Objectives:This study was aimed to determine the expression of VEGF in different histomorphological types of breast carcinoma in an attempt to clarify its potential clinical outcome.\u0000Materials and Methods: This study was conducted in the Department of Pathology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, Dhaka from March 2018 to January 2020. In this study, 45 diagnosed cases of breast carcinoma were enrolled. Histopathological slides of all cases were re-evaluated. Thin sections were taken on coated slides from each paraffin block and immunohistochemical staining was done with VEGF antibody.\u0000Results: Among 45 cases, 73.3% cases were invasive ductal carcinoma and 13.3% cases were invasive lobular carcinoma. The immunohistochemical expression of VEGF was positive in 60% cases. In this study, 100% cases of in-situ ductal carcinoma, 83.3% cases of invasive lobular carcinoma and 57.6% cases of invasive ductal carcinoma showed overexpression of VEGF. However VEGF expression did not show significant association with histomorphological types.\u0000Conclusion: VEGF expression was found in 60% of breast carcinoma cases. It may serve as a potential therapeutic target for the management of breast carcinoma.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 9-12","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73346545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The diagnosis of Hirschsprung’s disease (HD) is dependent on the histological study of rectal ganglion cells. Open rectal biopsy is the mainstay that requires general anesthesia (GA) and carries risk of many complications. Rectal punch biopsy has gained wide acceptance and has become the choice as it is simple, safe, having no need of anesthesia, done bedside with a simple biopsy forcep with high degree of accuracy and virtual absence of any complications. Objective: To find out the efficacy of rectal punch biopsy in the diagnosis of Hirschsprung’s disease. Materials and Methods: A cross sectional descriptive observational study was carried out with the histological findings of 60 rectal punch biopsies with corresponding 60 full thickness rectal biopsies from 60 suspected HD patients from March 2018 to February 2020. Sections made from the paraffin blocks were stained with H&E and were examined for the presence or absence of ganglion cells and hypertrophic nerve fibers in the submucosa. Then the relations were studied. These findings were compared with full thickness rectal biopsy. Result: There were 40(66.7%) cases of male and 20(33.3%) cases of female including 26 (43.3%) cases of infants. Out of 60 cases, 10 cases (seven inadequate and three suspicious) of punch biopsy were not compared with full thickness rectal biopsy. Out of 50 cases, 38(63.3%) cases were HD in punch biopsy; among these 36(92.3%) cases were HD and 2(18.2%) cases were Non-HD in full thickness rectal tissue biopsy. The accuracy of punch biopsy was measured by sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and efficiency of the test which were 92.3%, 81.8%, 94.7%, 75.0% and 90.0% respectively. Conclusion: The rectal punch biopsy is simple, safe, no need of anesthesia and can be done with a simple biopsy forcep with high degree of accuracy. KYAMC Journal Vol. 13, No. 01, April 2022: 37-40
{"title":"Histopathological Comparison between Punch and Full Thickness Rectal Biopsy in Diagnosis of Hirschsprung’s Disease","authors":"Halima Khatun Doly, Shakila Jannat, Afm Saleh, Shamimur Rahman, Debashish Chakraborty","doi":"10.3329/kyamcj.v13i1.59879","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59879","url":null,"abstract":"Background: The diagnosis of Hirschsprung’s disease (HD) is dependent on the histological study of rectal ganglion cells. Open rectal biopsy is the mainstay that requires general anesthesia (GA) and carries risk of many complications. Rectal punch biopsy has gained wide acceptance and has become the choice as it is simple, safe, having no need of anesthesia, done bedside with a simple biopsy forcep with high degree of accuracy and virtual absence of any complications.\u0000Objective: To find out the efficacy of rectal punch biopsy in the diagnosis of Hirschsprung’s disease.\u0000Materials and Methods: A cross sectional descriptive observational study was carried out with the histological findings of 60 rectal punch biopsies with corresponding 60 full thickness rectal biopsies from 60 suspected HD patients from March 2018 to February 2020. Sections made from the paraffin blocks were stained with H&E and were examined for the presence or absence of ganglion cells and hypertrophic nerve fibers in the submucosa. Then the relations were studied. These findings were compared with full thickness rectal biopsy.\u0000Result: There were 40(66.7%) cases of male and 20(33.3%) cases of female including 26 (43.3%) cases of infants. Out of 60 cases, 10 cases (seven inadequate and three suspicious) of punch biopsy were not compared with full thickness rectal biopsy. Out of 50 cases, 38(63.3%) cases were HD in punch biopsy; among these 36(92.3%) cases were HD and 2(18.2%) cases were Non-HD in full thickness rectal tissue biopsy. The accuracy of punch biopsy was measured by sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and efficiency of the test which were 92.3%, 81.8%, 94.7%, 75.0% and 90.0% respectively.\u0000Conclusion: The rectal punch biopsy is simple, safe, no need of anesthesia and can be done with a simple biopsy forcep with high degree of accuracy.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 37-40","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74748993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59882
A. Moniruddin, H. Raihan, Mst Nazmun Nahar Khanom, Tanvirul Hasan, Ba Ferdous, M. R. Khan, M. A. Rouf
An umbilical discharge is itself not a disease, but it is a symptom of many diseases. In children, it may be found to be associated with an underlying congenital abnormality like persistent OMD (Omphalo-mesenteric Duct) or Vitelline cysts or sinuses or umbilical granuloma or a diverticulum like the Meckel’s diverticulum which may possess ectopic gastric or pancreatic or even colonic mucosa, or the persistent allantois or a urachal cyst or an infected urachus etc. Umbilical discharge though rare in adults, it may be caused by diverse congenital or acquired conditions. The most common causes of umbilical discharge in adults are such acquired conditions as pilonidal sinus disease, infection of hair tufts and foreign bodies4, and specific and non-specific acute and chronic inflammation and abscess of the umbilicus, infected omphalolith etc. Very rarely the discharge may be due to endometriosis or metastatic carcinoma, umbilical hernia ulceration etc. Discharging umbilical abscess may be caused by bacteria that can enter as a result of penetrating trauma, rupture of the bowel, or abdominal surgery. Irrespective of aetiology, umbilical discharge is a distressing condition for the patient and the family members. Appropriate diagnostic aids and successful management strategies are now available. If not associated with malignant diseases or irreversible complications, the prognosis is excellent. KYAMC Journal Vol. 13, No. 01, April 2022: 50-55
{"title":"Umbilical Discharge","authors":"A. Moniruddin, H. Raihan, Mst Nazmun Nahar Khanom, Tanvirul Hasan, Ba Ferdous, M. R. Khan, M. A. Rouf","doi":"10.3329/kyamcj.v13i1.59882","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59882","url":null,"abstract":"An umbilical discharge is itself not a disease, but it is a symptom of many diseases. In children, it may be found to be associated with an underlying congenital abnormality like persistent OMD (Omphalo-mesenteric Duct) or Vitelline cysts or sinuses or umbilical granuloma or a diverticulum like the Meckel’s diverticulum which may possess ectopic gastric or pancreatic or even colonic mucosa, or the persistent allantois or a urachal cyst or an infected urachus etc. Umbilical discharge though rare in adults, it may be caused by diverse congenital or acquired conditions. The most common causes of umbilical discharge in adults are such acquired conditions as pilonidal sinus disease, infection of hair tufts and foreign bodies4, and specific and non-specific acute and chronic inflammation and abscess of the umbilicus, infected omphalolith etc. Very rarely the discharge may be due to endometriosis or metastatic carcinoma, umbilical hernia ulceration etc. Discharging umbilical abscess may be caused by bacteria that can enter as a result of penetrating trauma, rupture of the bowel, or abdominal surgery. Irrespective of aetiology, umbilical discharge is a distressing condition for the patient and the family members. Appropriate diagnostic aids and successful management strategies are now available. If not associated with malignant diseases or irreversible complications, the prognosis is excellent.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 50-55","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82245177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59878
U. Ghosh, Mosammat Afroza Jinnat, Imrul Kaes, Shakila Jannat, M. Solayman, Md Abdul Hadi Al Mamun
Background: Neonatal sepsis is defined as a clinical condition of bacteremia with clinical features of infection in the first 28 days of life. Neonatal sepsis is an important cause of neonatal deaths worldwide. If detected early and treated aggressively and appropriately with antibiotics with good supportive care, it can be possible to save a life. Objective: The present study is carried out to overview the clinical and investigations profile, and outcome of neonatal sepsis admitted in a neonatal intensive care unit (NICU). Materials and Methods: This is a retrospective descriptive study. This study included newborns diagnosed with neonatal sepsis admitted to the Neonatal Intensive Care Unit (NICU) of Khwaja Yunus Ali Medical College and Hospital, Sirajgonj from October 2020 to January 2022. The case records of 50 neonatal sepsis. The case records of these newborns were thoroughly studied and recorded for relevant information including detailed history including maternal, clinical evaluation, and available investigation. The outcome was also noted. Results: Among the 50 neonatal sepsis cases early-onset neonatal sepsis was 56%; where mostly preterm (74%) and low birth weight (44%). Clinical presentations were mostly reluctant to feed (70%) associated with other septic features. Septicemia only (36%), pneumonia (14%), neonatal intestinal obstruction (10%) were found as the main pattern of sepsis. Among the cases septic screening profile thrombocytopenia 84%, CRP Positive 78%, leukopenia 58%, anemia 26%, leukocytosis 22%, normal 20%, toxic granules or band form neutrophil 14%, positive blood culture 14% were found. Probable risk factors were found mainly low birth weight (78%) and prematurity (74%); overlapping with many other risk factors. Thirty-six percent were death among sepsis. Conclusion: In the neonatal intensive care unit mostly early-onset neonatal sepsis has been observed in outborn, premature, and Low Birth Weight (LBW) babies presenting with reluctance to feed with associated risk factors; where thrombocytopenia invariably found in sepsis screening and survival rate around sixty-five percent KYAMC Journal Vol. 13, No. 01, April 2022: 32-36
背景:新生儿脓毒症被定义为在出生后28天内以感染为临床特征的菌血症。新生儿败血症是全世界新生儿死亡的一个重要原因。如果及早发现并积极适当地使用抗生素进行治疗,并辅以良好的支持性护理,就有可能挽救生命。目的:本研究综述了新生儿重症监护病房(NICU)收治的新生儿脓毒症的临床、调查概况和预后。材料与方法:本研究为回顾性描述性研究。本研究纳入了2020年10月至2022年1月在Sirajgonj Khwaja Yunus Ali医学院和医院新生儿重症监护病房(NICU)确诊为新生儿败血症的新生儿。新生儿败血症50例。对这些新生儿的病例记录进行了全面的研究,并记录了相关信息,包括详细的病史,包括产妇、临床评估和现有的调查。会议还注意到结果。结果:50例新生儿败血症中,早发性新生儿败血症占56%;其中大多数是早产(74%)和低出生体重(44%)。临床表现多为不愿进食(70%)并伴有其他脓毒性特征。败血症(36%)、肺炎(14%)、新生儿肠梗阻(10%)是败血症的主要表现形式。脓毒症筛查中血小板减少84%,CRP阳性78%,白细胞减少58%,贫血26%,白细胞增多22%,正常20%,毒性颗粒或带状中性粒细胞14%,血培养阳性14%。可能的危险因素主要是低出生体重(78%)和早产(74%);与许多其他风险因素重叠。36%的人死于败血症。结论:在新生儿重症监护病房,早产和低出生体重(LBW)婴儿出现不愿进食并伴有相关危险因素,大多发生早发性新生儿脓毒症;在脓毒症筛查中发现血小板减少症患者的生存率约为65%。《amc杂志》Vol. 13, No. 01, April 2022: 32-36
{"title":"Sepsis Profile of Neonates Admitted to Neonatal Intensive Care Unit of a Tertiary Care Hospital","authors":"U. Ghosh, Mosammat Afroza Jinnat, Imrul Kaes, Shakila Jannat, M. Solayman, Md Abdul Hadi Al Mamun","doi":"10.3329/kyamcj.v13i1.59878","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59878","url":null,"abstract":"Background: Neonatal sepsis is defined as a clinical condition of bacteremia with clinical features of infection in the first 28 days of life. Neonatal sepsis is an important cause of neonatal deaths worldwide. If detected early and treated aggressively and appropriately with antibiotics with good supportive care, it can be possible to save a life.\u0000Objective: The present study is carried out to overview the clinical and investigations profile, and outcome of neonatal sepsis admitted in a neonatal intensive care unit (NICU).\u0000Materials and Methods: This is a retrospective descriptive study. This study included newborns diagnosed with neonatal sepsis admitted to the Neonatal Intensive Care Unit (NICU) of Khwaja Yunus Ali Medical College and Hospital, Sirajgonj from October 2020 to January 2022. The case records of 50 neonatal sepsis. The case records of these newborns were thoroughly studied and recorded for relevant information including detailed history including maternal, clinical evaluation, and available investigation. The outcome was also noted.\u0000Results: Among the 50 neonatal sepsis cases early-onset neonatal sepsis was 56%; where mostly preterm (74%) and low birth weight (44%). Clinical presentations were mostly reluctant to feed (70%) associated with other septic features. Septicemia only (36%), pneumonia (14%), neonatal intestinal obstruction (10%) were found as the main pattern of sepsis. Among the cases septic screening profile thrombocytopenia 84%, CRP Positive 78%, leukopenia 58%, anemia 26%, leukocytosis 22%, normal 20%, toxic granules or band form neutrophil 14%, positive blood culture 14% were found. Probable risk factors were found mainly low birth weight (78%) and prematurity (74%); overlapping with many other risk factors. Thirty-six percent were death among sepsis.\u0000Conclusion: In the neonatal intensive care unit mostly early-onset neonatal sepsis has been observed in outborn, premature, and Low Birth Weight (LBW) babies presenting with reluctance to feed with associated risk factors; where thrombocytopenia invariably found in sepsis screening and survival rate around sixty-five percent\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 32-36","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86693923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A number of risk factors are responsible for ischemic stroke some are modifiable and some are not modifiable. Homocysteine is a modifiable, independent risk factor of ischemic stroke. Objective: To evaluate the effectiveness of folic acid on homocysteine levels in ischemic stroke patients. Materials and Methods: This study was an experimental study carried out in the Department of Pharmacology and Therapeutics, Rajshahi Medical College in collaboration with the Department of Neurology, Rajshahi Medical College Hospital from July 2016 to June 2017. A total number of 90 ischemic stroke patients diagnosed by CT scan findings who came for treatment in the Neurology department of Rajshahi Medical College Hospital were enrolled in this study. Simple random sampling is done. The patients were divided into two groups: experimental group (45 patients) who were treated with 5mg folic acid along with other traditional treatment, control group (45 patients) who were treated by only traditional therapy given by the neurology department. Before starting treatment, along with other investigations, serum homocysteine level of both experimental and control groups was estimated. After three months of continuous treatment with folic acid in the experimental group, the serum homocysteine level of both groups was measured again. Data were analyzed using SPSS version 16 for windows. Results: The results showed that there was a small numerical difference in homocysteine level before and after treatment in the experimental and control group, yet the change was statistically significant in the experimental group after three months of treatment with 5mg folic acid. Conclusion: It is revealed that use of folic acid may play an important role in reducing homocysteine level in ischemic stroke patients. KYAMC Journal Vol. 13, No. 01, April 2022: 13-17
背景:一些危险因素是缺血性中风的原因,有些是可以改变的,有些是不可改变的。同型半胱氨酸是缺血性脑卒中可改变的独立危险因素。目的:探讨叶酸对缺血性脑卒中患者同型半胱氨酸水平的影响。材料与方法:本研究于2016年7月至2017年6月在Rajshahi医学院药理学与治疗学系与Rajshahi医学院附属医院神经内科合作开展的实验研究。本研究共纳入90例在Rajshahi医学院附属医院神经内科接受CT扫描诊断的缺血性脑卒中患者。简单随机抽样就完成了。将患者分为两组:实验组(45例)在给予5mg叶酸治疗的同时给予其他传统治疗;对照组(45例)只给予神经内科传统治疗。在开始治疗前,与其他调查一起,对实验组和对照组的血清同型半胱氨酸水平进行了估计。实验组连续给予叶酸治疗3个月后,再次测定两组血清同型半胱氨酸水平。数据分析使用SPSS version 16 for windows。结果:实验组与对照组治疗前后同型半胱氨酸水平数值差异不大,但实验组5mg叶酸治疗3个月后变化有统计学意义。结论:叶酸对降低缺血性脑卒中患者同型半胱氨酸水平有重要作用。KYAMC学报第13卷第01期,2022年4月:13-17
{"title":"Effect of Folic Acid on Homocysteine Level in Ischemic Stroke Patients in a Tertiary Level Hospital in Rajshahi.","authors":"Lotifa Haque, Md. Anwar Habib, Md. Yousuf Ali, Sonia Nilufar, Tarifat Alam, M. Hoque","doi":"10.3329/kyamcj.v13i1.59875","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59875","url":null,"abstract":"Background: A number of risk factors are responsible for ischemic stroke some are modifiable and some are not modifiable. Homocysteine is a modifiable, independent risk factor of ischemic stroke.\u0000Objective: To evaluate the effectiveness of folic acid on homocysteine levels in ischemic stroke patients.\u0000Materials and Methods: This study was an experimental study carried out in the Department of Pharmacology and Therapeutics, Rajshahi Medical College in collaboration with the Department of Neurology, Rajshahi Medical College Hospital from July 2016 to June 2017. A total number of 90 ischemic stroke patients diagnosed by CT scan findings who came for treatment in the Neurology department of Rajshahi Medical College Hospital were enrolled in this study. Simple random sampling is done. The patients were divided into two groups: experimental group (45 patients) who were treated with 5mg folic acid along with other traditional treatment, control group (45 patients) who were treated by only traditional therapy given by the neurology department. Before starting treatment, along with other investigations, serum homocysteine level of both experimental and control groups was estimated. After three months of continuous treatment with folic acid in the experimental group, the serum homocysteine level of both groups was measured again. Data were analyzed using SPSS version 16 for windows.\u0000Results: The results showed that there was a small numerical difference in homocysteine level before and after treatment in the experimental and control group, yet the change was statistically significant in the experimental group after three months of treatment with 5mg folic acid.\u0000Conclusion: It is revealed that use of folic acid may play an important role in reducing homocysteine level in ischemic stroke patients.\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 13-17","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75928696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.3329/kyamcj.v13i1.59872
Akm Shahidur Rahman
Abstract not available KYAMC Journal Vol. 13, No. 01, April 2022: 1-3
《中华医学杂志》第13卷第01期,2022年4月:1-3
{"title":"Antibiotic Resistance in Bangladesh: Should Take Necessary Action Before the Situation Goes Out of Control!","authors":"Akm Shahidur Rahman","doi":"10.3329/kyamcj.v13i1.59872","DOIUrl":"https://doi.org/10.3329/kyamcj.v13i1.59872","url":null,"abstract":"Abstract not available\u0000KYAMC Journal Vol. 13, No. 01, April 2022: 1-3","PeriodicalId":17948,"journal":{"name":"KYAMC Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74644498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}