Pub Date : 2024-07-30DOI: 10.1080/10428194.2024.2385495
Jeffrey Ahn, Yi Ouyang, Graham Velasco, Ann Eapen, Helen Ma
{"title":"A case report of solitary presentations of large B-cell lymphoma of immune-privileged sites (IP-LBCL) in the testis, vitreous body, and skin.","authors":"Jeffrey Ahn, Yi Ouyang, Graham Velasco, Ann Eapen, Helen Ma","doi":"10.1080/10428194.2024.2385495","DOIUrl":"https://doi.org/10.1080/10428194.2024.2385495","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since bacteremia complicates childhood Acute myeloid leukemia (AML) patients, we assessed bacteremia rates in Israeli children with de-novo AML. All chemotherapy courses of patients enrolled in NOPHO-DBH-2012 AML protocol were included. Down syndrome, acute promyelocytic leukemia were excluded. Among 69 patients, seven had focal bacterial infections. Of the remaining 62, 77.4% had 1-8 bacteremias. Of 238 chemotherapy courses, 98 (41.2%) had bacteremia: 66 (67.3%) predominantly Gram-negative rods (GNR); 28 (28.6%) Gram-positive cocci. Escherichia coli; followed by Klebsiella were most common. Older age, Arab ethnicity, and presenting white blood cell count were associated with an increased risk of bacteremia in the univariable analysis, but these associations were not confirmed in the multivariable analysis. Mortality was high (9.7%), and bacteremia increased PICU utilization 7-fold half from GNR. Most isolates were sensitive to vancomycin/meropenem (94.7%), but GNR had low sensitivity to quinolones (61.8%). High mortality and morbidity of de-novo AML patients from predominantly GNR bacteremia require specific interventions but limited susceptibility to quinolones hampers prophylaxis.
{"title":"National study reveals gram negative bacteremia on contemporary pediatric AML protocol.","authors":"Nira Arad-Cohen, Yoav Messinger, Shlomit Barzilai-Birenboim, Miriam Ben-Harosh, Michal Golan-Malki, Hila Rosenfeld-Keidar, Sigal Weinreb, Yael Shachor-Meyouhas, Halima Dabaja-Younis","doi":"10.1080/10428194.2024.2385496","DOIUrl":"https://doi.org/10.1080/10428194.2024.2385496","url":null,"abstract":"<p><p>Since bacteremia complicates childhood Acute myeloid leukemia (AML) patients, we assessed bacteremia rates in Israeli children with <i>de-novo</i> AML. All chemotherapy courses of patients enrolled in NOPHO-DBH-2012 AML protocol were included. Down syndrome, acute promyelocytic leukemia were excluded. Among 69 patients, seven had focal bacterial infections. Of the remaining 62, 77.4% had 1-8 bacteremias. Of 238 chemotherapy courses, 98 (41.2%) had bacteremia: 66 (67.3%) predominantly Gram-negative rods (GNR); 28 (28.6%) Gram-positive cocci. <i>Escherichia coli</i>; followed by Klebsiella were most common. Older age, Arab ethnicity, and presenting white blood cell count were associated with an increased risk of bacteremia in the univariable analysis, but these associations were not confirmed in the multivariable analysis. Mortality was high (9.7%), and bacteremia increased PICU utilization 7-fold half from GNR. Most isolates were sensitive to vancomycin/meropenem (94.7%), but GNR had low sensitivity to quinolones (61.8%). High mortality and morbidity of de-novo AML patients from predominantly GNR bacteremia require specific interventions but limited susceptibility to quinolones hampers prophylaxis.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-29DOI: 10.1080/10428194.2024.2385498
Yu Jeong Choi, Hye Won Kook, Seung-Tae Lee, Jaewoo Song, Jong Rak Choi, June-Won Cheong, Saeam Shin
{"title":"The utility of next generation sequencing-based minimal residual disease monitoring in a post-myeloproliferative neoplasm acute myeloid leukemia patient: a case report.","authors":"Yu Jeong Choi, Hye Won Kook, Seung-Tae Lee, Jaewoo Song, Jong Rak Choi, June-Won Cheong, Saeam Shin","doi":"10.1080/10428194.2024.2385498","DOIUrl":"https://doi.org/10.1080/10428194.2024.2385498","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.1080/10428194.2024.2382330
Urvish Jain, Faraan Rahim, Bhav Jain, Angelin Tresa Mathew, Erin Jay Garbes Feliciano, Edward Christopher Dee, Kaitlyn Lapen, Francis Lee, Fumiko Chino, Douglas Tremblay, Jennifer J Tsai
{"title":"Trends in location of death for individuals with acute myeloid leukemia in the United States.","authors":"Urvish Jain, Faraan Rahim, Bhav Jain, Angelin Tresa Mathew, Erin Jay Garbes Feliciano, Edward Christopher Dee, Kaitlyn Lapen, Francis Lee, Fumiko Chino, Douglas Tremblay, Jennifer J Tsai","doi":"10.1080/10428194.2024.2382330","DOIUrl":"https://doi.org/10.1080/10428194.2024.2382330","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-27DOI: 10.1080/10428194.2024.2383728
S Sorella, G M Assanto, Gianna Maria D'Elia, Giorgia Annechini, Matteo Totaro, Renata Celia, Leonardo Bruno, Fabio Placidi, M Martelli, I Del Giudice
{"title":"A case of posterior reversible encephalopathy syndrome (PRES) in an elderly patient with advanced classical Hodgkin Lymphoma during frontline treatment with brentuximab vedotin plus AVD.","authors":"S Sorella, G M Assanto, Gianna Maria D'Elia, Giorgia Annechini, Matteo Totaro, Renata Celia, Leonardo Bruno, Fabio Placidi, M Martelli, I Del Giudice","doi":"10.1080/10428194.2024.2383728","DOIUrl":"https://doi.org/10.1080/10428194.2024.2383728","url":null,"abstract":"","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.1080/10428194.2024.2382916
Pornpun Sripornsawan, Shevachut Chavananon, Sirinthip Kittivisuit, Natsaruth Songthawee, Edward B McNeil, Thirachit Chotsampancharoen
Although there have been advances in treating pediatric patients with acute myeloid leukemia (AML) in developed countries, outcomes in low- to middle-income countries remain poor. The goal of this study was to investigate the outcomes in children with AML who were treated at a tertiary care center in Thailand. We divided the study into 4 research periods based on the chemotherapy protocols employed. The 5-year probabilities of event-free survival (pEFS) rates for periods 1-4 were 19.0%, 20.6%, 17.4%, and 37.3% (p value = 0.32), while the 5-year probabilities of overall survival (pOS) rates were 19.0%, 24.7%, 18.7%, and 42.5% (p value = 0.18), respectively. The multivariable model indicated an improvement in 5-year pOS between periods 1 and 4 (p value = 0.04). Age, white blood cell count, and study period were significant predictors of survival outcomes. The pOS of AML patients improved over time, increasing from 19.0% to 42.5%.
{"title":"Long-term survival outcome of childhood acute myeloid leukemia: a 43-year experience in Thailand, a resource-limited country.","authors":"Pornpun Sripornsawan, Shevachut Chavananon, Sirinthip Kittivisuit, Natsaruth Songthawee, Edward B McNeil, Thirachit Chotsampancharoen","doi":"10.1080/10428194.2024.2382916","DOIUrl":"https://doi.org/10.1080/10428194.2024.2382916","url":null,"abstract":"<p><p>Although there have been advances in treating pediatric patients with acute myeloid leukemia (AML) in developed countries, outcomes in low- to middle-income countries remain poor. The goal of this study was to investigate the outcomes in children with AML who were treated at a tertiary care center in Thailand. We divided the study into 4 research periods based on the chemotherapy protocols employed. The 5-year probabilities of event-free survival (pEFS) rates for periods 1-4 were 19.0%, 20.6%, 17.4%, and 37.3% (<i>p</i> value = 0.32), while the 5-year probabilities of overall survival (pOS) rates were 19.0%, 24.7%, 18.7%, and 42.5% (<i>p</i> value = 0.18), respectively. The multivariable model indicated an improvement in 5-year pOS between periods 1 and 4 (<i>p</i> value = 0.04). Age, white blood cell count, and study period were significant predictors of survival outcomes. The pOS of AML patients improved over time, increasing from 19.0% to 42.5%.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.1080/10428194.2024.2382923
Jacob Fang, Nakul Shankar, Liming Bao, Mary Haag, Billie Carstens, Changlee S Pang
Near-tetraploidy/tetraploidy (NT/T) is a cytogenetic alteration in acute myeloid leukemia (AML). In AML, specific chromosomal alterations are associated with clinical, morphological, and immunophenotypic features. The impact of cytogenetics on the prognosis of AML is well established. However, the prognostic implication of NT/T on AML remains unclear. Our aim is to further characterize the clinical, morphologic, immunophenotypic, molecular mutational, and prognostic features of NT/T AML. This retrospective chart review of NT/T AML cases showed NT/T AML was more common in older adult males, with predominately large blasts and myelodysplasia-related features. The most common lineage of dysplasia was dysgranulopoiesis in 77.8% of cases. Cases displayed multiple cytogenetic abnormalities, with only four showing NT/T as the sole abnormality. TP53 was the most common molecular mutation associated with NT/T AML (44.5%). Of the patients receiving treatment for NT/T AML, 80% achieved a CR. The median overall survival for the entire cohort was 4.5 months.
近四倍体/四倍体（NT/T）是急性髓性白血病（AML）的一种细胞遗传学改变。在急性髓细胞白血病中，特定的染色体改变与临床、形态学和免疫表型特征相关。细胞遗传学对急性髓细胞白血病预后的影响已得到公认。然而，NT/T 对急性髓细胞白血病预后的影响仍不明确。我们的目的是进一步描述 NT/T AML 的临床、形态学、免疫表型、分子突变和预后特征。对NT/T型急性髓细胞白血病病例的回顾性病历回顾显示，NT/T型急性髓细胞白血病多见于老年男性，主要表现为大泡和骨髓增生异常相关特征。在77.8%的病例中，最常见的发育不良系是粒细胞生成障碍。病例显示多种细胞遗传学异常，只有4例显示NT/T为唯一异常。TP53 是与 NT/T AML 相关的最常见分子突变（44.5%）。在接受NT/T AML治疗的患者中，80%达到了CR。整个组群的中位总生存期为4.5个月。
{"title":"Near-tetraploidy/tetraploidy acute myeloid leukemia with clinical, pathologic and molecular characteristics.","authors":"Jacob Fang, Nakul Shankar, Liming Bao, Mary Haag, Billie Carstens, Changlee S Pang","doi":"10.1080/10428194.2024.2382923","DOIUrl":"https://doi.org/10.1080/10428194.2024.2382923","url":null,"abstract":"<p><p>Near-tetraploidy/tetraploidy (NT/T) is a cytogenetic alteration in acute myeloid leukemia (AML). In AML, specific chromosomal alterations are associated with clinical, morphological, and immunophenotypic features. The impact of cytogenetics on the prognosis of AML is well established. However, the prognostic implication of NT/T on AML remains unclear. Our aim is to further characterize the clinical, morphologic, immunophenotypic, molecular mutational, and prognostic features of NT/T AML. This retrospective chart review of NT/T AML cases showed NT/T AML was more common in older adult males, with predominately large blasts and myelodysplasia-related features. The most common lineage of dysplasia was dysgranulopoiesis in 77.8% of cases. Cases displayed multiple cytogenetic abnormalities, with only four showing NT/T as the sole abnormality<i>. TP53</i> was the most common molecular mutation associated with NT/T AML (44.5%). Of the patients receiving treatment for NT/T AML, 80% achieved a CR. The median overall survival for the entire cohort was 4.5 months.</p>","PeriodicalId":18047,"journal":{"name":"Leukemia & Lymphoma","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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