首页 > 最新文献

LOJ Medical Sciences最新文献

英文 中文
Herpes Zoster Affecting the Lower Extremity in An Older Patient: A Clinical Image 影响老年患者下肢的带状疱疹:临床影像
Pub Date : 2018-12-14 DOI: 10.32474/LOJMS.2018.02.000144
Burak Unal, Yigit Can Ahıska, N. Uslu, S. Avci
Herpes zoster is a viral disease which is the reactivated form of varicella zoster virus. Herpes zoster usually characterized by skin eruptions and pain in specific dermatomes [1]. About 50% of lesions of herpes zoster in United States occur elderly patients. The highest incidence of disease is 7th decade of life [2]. Herpes zoster symptoms can mimic sciatalgia or weakness related to spine root compression [1]. A 67-year-old woman admitted with a history of diabetes mellitus and hypertension, presented to emergency department right thigh pain for three days. On examination, patient was afebrile, with stable vital signs. There was a characteristic vesicular rash on the right thigh and also hyperesthesia noted over the right thigh (Figure 1). Any motor deficit was detected in the patient. Any laboratory abnormalities were detected in the patient. The patient was discharged from emergency room after prescribing nonsteroidal anti-inflammatory drug and oral valacyclovir. Herpes zoster infections are commonly seen in the community. The complications of this infection may vary. We presented in herein a patient mimicking sciatalgia.
带状疱疹是一种由水痘带状疱疹病毒活化而成的病毒性疾病。带状疱疹通常以特定皮节的皮肤皮疹和疼痛为特征[1]。在美国,大约50%的带状疱疹病变发生在老年患者身上。发病率最高的年龄段是70岁[2]。带状疱疹症状可模仿与脊柱根受压相关的坐骨痛或虚弱[1]。一名67岁女性,因糖尿病和高血压病史入院,右大腿疼痛3天。经检查,患者无发热,生命体征稳定。右大腿有特征性的水疱疹,右大腿也有感觉亢进(图1)。患者有运动障碍。在病人身上检测到任何实验室异常。患者在给予非甾体类抗炎药和口服伐昔洛韦后出院。带状疱疹感染在社区中很常见。这种感染的并发症可能各不相同。我们在这里提出了一个病人模拟坐骨神经痛。
{"title":"Herpes Zoster Affecting the Lower Extremity in An Older Patient: A Clinical Image","authors":"Burak Unal, Yigit Can Ahıska, N. Uslu, S. Avci","doi":"10.32474/LOJMS.2018.02.000144","DOIUrl":"https://doi.org/10.32474/LOJMS.2018.02.000144","url":null,"abstract":"Herpes zoster is a viral disease which is the reactivated form of varicella zoster virus. Herpes zoster usually characterized by skin eruptions and pain in specific dermatomes [1]. About 50% of lesions of herpes zoster in United States occur elderly patients. The highest incidence of disease is 7th decade of life [2]. Herpes zoster symptoms can mimic sciatalgia or weakness related to spine root compression [1]. A 67-year-old woman admitted with a history of diabetes mellitus and hypertension, presented to emergency department right thigh pain for three days. On examination, patient was afebrile, with stable vital signs. There was a characteristic vesicular rash on the right thigh and also hyperesthesia noted over the right thigh (Figure 1). Any motor deficit was detected in the patient. Any laboratory abnormalities were detected in the patient. The patient was discharged from emergency room after prescribing nonsteroidal anti-inflammatory drug and oral valacyclovir. Herpes zoster infections are commonly seen in the community. The complications of this infection may vary. We presented in herein a patient mimicking sciatalgia.","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89379004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mitochondrial Abnormalities at Autopsy of Fetal Noncompaction 胎儿不压实尸检中的线粒体异常
Pub Date : 2018-12-14 DOI: 10.32474/lojms.2018.02.000145
J. Finsterer, S. Mahjoub
In a recent article, Tian et al. [1] reported about the echocardiographic and pathological findings in 9 fetuses with left ventricular hyper trabeculation/non-compaction (LVHT). We have the following comments and concerns. The authors differentiate between non-compaction cardiomyopathy (NCCM) and left ventricular non-compaction (LVNC). In our view these are two different terms which describe the same entity. Which is the difference between NCCM and LVNC in the authors’ view? Absence of additional cardiac abnormalities should not be a differentiating criterion.
在最近的一篇文章中,Tian等[1]报道了9例左室超小梁/非压实(LVHT)胎儿的超声心动图和病理结果。我们有以下评论和关切。作者区分了非压实性心肌病(NCCM)和左心室非压实性心肌病(LVNC)。我们认为,这是描述同一实体的两个不同术语。在作者看来,NCCM和LVNC的区别是什么?无其他心脏异常不应作为鉴别标准。
{"title":"Mitochondrial Abnormalities at Autopsy of Fetal Noncompaction","authors":"J. Finsterer, S. Mahjoub","doi":"10.32474/lojms.2018.02.000145","DOIUrl":"https://doi.org/10.32474/lojms.2018.02.000145","url":null,"abstract":"In a recent article, Tian et al. [1] reported about the echocardiographic and pathological findings in 9 fetuses with left ventricular hyper trabeculation/non-compaction (LVHT). We have the following comments and concerns. The authors differentiate between non-compaction cardiomyopathy (NCCM) and left ventricular non-compaction (LVNC). In our view these are two different terms which describe the same entity. Which is the difference between NCCM and LVNC in the authors’ view? Absence of additional cardiac abnormalities should not be a differentiating criterion.","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84145485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Anthrax Case Which Generates as Skin Lesion and Leads to Sepsis 引起皮肤损伤并导致败血症的炭疽病例
Pub Date : 2018-12-13 DOI: 10.32474/LOJMS.2018.02.000143
M. Dülger, Kenan Murat, S. Avci
{"title":"An Anthrax Case Which Generates as Skin Lesion and Leads to Sepsis","authors":"M. Dülger, Kenan Murat, S. Avci","doi":"10.32474/LOJMS.2018.02.000143","DOIUrl":"https://doi.org/10.32474/LOJMS.2018.02.000143","url":null,"abstract":"","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86986511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual Addiction Among College Students 大学生的性成瘾问题
Pub Date : 2018-12-07 DOI: 10.32474/lojms.2018.02.000142
Morteza Alibakhshikenari
Previous research suggests that not only is sexual addiction a problem within our society, its prevalence is on the rise Seegers [1]. Exposure to sexually explicit stimuli helps to create this problem. The advent of broadband internet has made this type of material more available than ever before Hall [2]. Pair this alongside other factors that contribute to the development of sexual addiction; childhood abuse and trauma, difficulties in formulating attachments and lack of coping skills and one can see the ease at which this problem can spread. Although the DSM-V has not yet recognized this as an actual disorder, nor included a workable diagnosis, it does appear to be a growing problem. Previous literature by individuals such as; Patrick Carnes and Ariel Goodman has provided us with actual diagnostic criterion that could be utilized to do just that. Evidence supports the fact that the problem does exist and that it is an uncontrollable maladaptive behavior. Our research will help to expand this knowledge by utilizing university students to establish if sexual addiction is presenting within the population we will sample. In determining this we can then move forward with research so as to better understand how and why this may be occurring.
先前的研究表明,性成瘾不仅是我们社会中的一个问题,而且其患病率呈上升趋势(Seegers[1])。暴露在露骨的性刺激下有助于产生这个问题。宽带互联网的出现使得这类材料比以往任何时候都更容易获得,霍尔[2]。将这一点与其他导致性成瘾的因素结合起来;童年时期的虐待和创伤,形成依恋的困难以及缺乏应对技能人们可以看到这个问题很容易传播。尽管DSM-V尚未将其视为一种实际的疾病,也没有纳入可行的诊断方法,但它确实是一个日益严重的问题。以前的个人文献,如;Patrick Carnes和Ariel Goodman为我们提供了实际的诊断标准,可以用来做到这一点。证据表明问题确实存在,而且这是一种无法控制的适应不良行为。我们的研究将通过利用大学生来确定我们将取样的人群中是否存在性成瘾,从而有助于扩大这方面的知识。在确定这一点后,我们可以继续进行研究,以便更好地理解这种情况是如何发生的以及为什么会发生。
{"title":"Sexual Addiction Among College Students","authors":"Morteza Alibakhshikenari","doi":"10.32474/lojms.2018.02.000142","DOIUrl":"https://doi.org/10.32474/lojms.2018.02.000142","url":null,"abstract":"Previous research suggests that not only is sexual addiction a problem within our society, its prevalence is on the rise Seegers [1]. Exposure to sexually explicit stimuli helps to create this problem. The advent of broadband internet has made this type of material more available than ever before Hall [2]. Pair this alongside other factors that contribute to the development of sexual addiction; childhood abuse and trauma, difficulties in formulating attachments and lack of coping skills and one can see the ease at which this problem can spread. Although the DSM-V has not yet recognized this as an actual disorder, nor included a workable diagnosis, it does appear to be a growing problem. Previous literature by individuals such as; Patrick Carnes and Ariel Goodman has provided us with actual diagnostic criterion that could be utilized to do just that. Evidence supports the fact that the problem does exist and that it is an uncontrollable maladaptive behavior. Our research will help to expand this knowledge by utilizing university students to establish if sexual addiction is presenting within the population we will sample. In determining this we can then move forward with research so as to better understand how and why this may be occurring.","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87322679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraction and Determination of Anti-Oxidant Activity of Polyphenols from Carrot Pomace, and Their Use in Date Oat Bar 胡萝卜渣中多酚的提取、抗氧化活性测定及其在枣燕麦棒中的应用
Pub Date : 2018-12-03 DOI: 10.32474/LOJMS.2018.02.000138
Hammad Naeem, U. Niaz, Sarmad Sattar
The carrot belongs to the family Apiaceae. The carrot originated in Asia. Carrots are particularly rich in carotene (pro-vitamin A) and also significant amount of polyphenols. Carrots are also known to have polyphenols and antioxidants. Carrots are consumed either fresh, as a salad crop, or cooked. Large quantities are also processed, either alone or in mixtures with other vegetables, by canning or freezing. Polyphenols are a group of chemical substances found in plants. Polyphenols are naturally present in plants. Polyphenols are not essential nutrients meaning that they are not required by the human body for sustaining life, but they can exert beneficial functions [1]. Fruits and vegetables are sources of polyphenols. Polyphenols play an important role in the prevention of degenerative diseases such as cancer and cardiovascular diseases. Polyphenols are antioxidants. Antioxidants are the substances that prevent oxidation. Antioxidants, polyphenols and carotenoids, may help protect cells from damage caused by free radicals. Extraction of molecules from biological materials by conventional techniques, such as simple maceration, is time consuming. The development of modern techniques such as extraction assisted by microwave or extraction assisted by ultrasound. Sonication breaks the cell membranes. It reduces considerably the extraction time and increasing the extract yield. The application of ultrasound disrupts the cell wall structures and accelerates diffusion through membranes; thus, the cell lyses and hence facilitates the release of cell contents. The potential of reducing waste to combat the food security issues are high, as it is estimated that by 50% reduction in current food waste, the world would be saving 1314 trillion kcal per year. This represent a reduction of about 22% of the number of additional calories needed to feed the projected population by 2050. By the year 2100, the global population is expected to increase to 11.2 billion. To feed this projected population and address the food security and the environmental issues, waste reduction and utilization food resources are the important strategies to be developed. The nutritional characterization of waste from fruits Abstract
胡萝卜属于蜜蜂科。胡萝卜原产于亚洲。胡萝卜尤其富含胡萝卜素(维生素A原)和大量的多酚。胡萝卜还含有多酚和抗氧化剂。胡萝卜既可以作为沙拉作物新鲜食用,也可以煮熟食用。大量的蔬菜也通过罐装或冷冻的方式进行加工,要么单独加工,要么与其他蔬菜混合。多酚是植物中发现的一组化学物质。多酚天然存在于植物中。多酚不是人体维持生命所必需的营养物质,但它们可以发挥有益的功能。水果和蔬菜是多酚的来源。多酚在预防退行性疾病(如癌症和心血管疾病)方面发挥着重要作用。多酚是抗氧化剂。抗氧化剂是防止氧化的物质。抗氧化剂、多酚和类胡萝卜素可能有助于保护细胞免受自由基的损害。从生物材料中提取分子的传统技术,如简单浸渍,是耗时的。现代技术的发展,如微波辅助提取或超声辅助提取。超声波破坏细胞膜。大大缩短了提取时间,提高了提取率。超声波的应用破坏了细胞壁结构,加速了细胞膜的扩散;因此,细胞溶解,从而促进细胞内容物的释放。通过减少浪费来解决粮食安全问题的潜力很大,据估计,如果目前的食物浪费减少50%,世界每年将节省1314万亿大卡。这意味着到2050年养活预计人口所需的额外卡路里减少了约22%。到2100年,全球人口预计将增加到112亿。为了养活预计的人口,解决粮食安全和环境问题,减少浪费和利用粮食资源是需要制定的重要战略。水果废弃物的营养特性研究
{"title":"Extraction and Determination of Anti-Oxidant Activity of Polyphenols from Carrot Pomace, and Their Use in Date Oat Bar","authors":"Hammad Naeem, U. Niaz, Sarmad Sattar","doi":"10.32474/LOJMS.2018.02.000138","DOIUrl":"https://doi.org/10.32474/LOJMS.2018.02.000138","url":null,"abstract":"The carrot belongs to the family Apiaceae. The carrot originated in Asia. Carrots are particularly rich in carotene (pro-vitamin A) and also significant amount of polyphenols. Carrots are also known to have polyphenols and antioxidants. Carrots are consumed either fresh, as a salad crop, or cooked. Large quantities are also processed, either alone or in mixtures with other vegetables, by canning or freezing. Polyphenols are a group of chemical substances found in plants. Polyphenols are naturally present in plants. Polyphenols are not essential nutrients meaning that they are not required by the human body for sustaining life, but they can exert beneficial functions [1]. Fruits and vegetables are sources of polyphenols. Polyphenols play an important role in the prevention of degenerative diseases such as cancer and cardiovascular diseases. Polyphenols are antioxidants. Antioxidants are the substances that prevent oxidation. Antioxidants, polyphenols and carotenoids, may help protect cells from damage caused by free radicals. Extraction of molecules from biological materials by conventional techniques, such as simple maceration, is time consuming. The development of modern techniques such as extraction assisted by microwave or extraction assisted by ultrasound. Sonication breaks the cell membranes. It reduces considerably the extraction time and increasing the extract yield. The application of ultrasound disrupts the cell wall structures and accelerates diffusion through membranes; thus, the cell lyses and hence facilitates the release of cell contents. The potential of reducing waste to combat the food security issues are high, as it is estimated that by 50% reduction in current food waste, the world would be saving 1314 trillion kcal per year. This represent a reduction of about 22% of the number of additional calories needed to feed the projected population by 2050. By the year 2100, the global population is expected to increase to 11.2 billion. To feed this projected population and address the food security and the environmental issues, waste reduction and utilization food resources are the important strategies to be developed. The nutritional characterization of waste from fruits Abstract","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81265576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Left Ventricular Hypertrabeculation / Noncompaction Associated with a SDHD Mutation 与SDHD突变相关的左室超小梁/非压实
Pub Date : 2018-12-03 DOI: 10.32474/LOJMS.2018.02.000137
J. Finsterer, S. Zarrouk-Mahjoub
In a recent article Alston et al. reported about a male neonate with mitochondrial disorder (MID) due to the novel homozygous mutation c.275A>G in the SDHD gene [1]. The only affected organ in this boy was the heart [1]. We have the following comments and concerns. In the vast majority of the cases noncompaction, also known as left ventricular hypertrabeculation (LVHT), is congenital [2] and LVHT can be detected already prenatally by fetal echocardiography [3]. Which was the reason why LVHT was recognised neither on fetal echocardiography nor on fetal cardiac MRI and not before postnatal echocardiography? Since it is quite unusual that LVHT is missed on echocardiography and cardiac MRI it can be speculated that it developed after the last cardiac imaging at gestation week 32. Were fetal echocardiographies and fetal cardiac MRI reviewed after detection of LVHT on postnatal echocardiography and autopsy?
在最近的一篇文章中,Alston等人报道了一名患有线粒体疾病(MID)的男婴,这是由于SDHD基因[1]中出现了新的纯合突变c.275A>G。这个男孩唯一受影响的器官是心脏。我们有以下评论和关切。在绝大多数情况下,不压实,也被称为左室超纤(LVHT),是先天性的,LVHT可以在产前通过胎儿超声心动图[3]检测到。这就是为什么LVHT既没有在胎儿超声心动图上被识别,也没有在胎儿心脏MRI上被识别,也没有在产后超声心动图上被识别的原因?由于在超声心动图和心脏MRI上遗漏LVHT是非常罕见的,因此可以推测它是在妊娠第32周最后一次心脏成像后发生的。在产后超声心动图和尸检中发现LVHT后是否复查胎儿超声心动图和胎儿心脏MRI ?
{"title":"Left Ventricular Hypertrabeculation / Noncompaction Associated with a SDHD Mutation","authors":"J. Finsterer, S. Zarrouk-Mahjoub","doi":"10.32474/LOJMS.2018.02.000137","DOIUrl":"https://doi.org/10.32474/LOJMS.2018.02.000137","url":null,"abstract":"In a recent article Alston et al. reported about a male neonate with mitochondrial disorder (MID) due to the novel homozygous mutation c.275A>G in the SDHD gene [1]. The only affected organ in this boy was the heart [1]. We have the following comments and concerns. In the vast majority of the cases noncompaction, also known as left ventricular hypertrabeculation (LVHT), is congenital [2] and LVHT can be detected already prenatally by fetal echocardiography [3]. Which was the reason why LVHT was recognised neither on fetal echocardiography nor on fetal cardiac MRI and not before postnatal echocardiography? Since it is quite unusual that LVHT is missed on echocardiography and cardiac MRI it can be speculated that it developed after the last cardiac imaging at gestation week 32. Were fetal echocardiographies and fetal cardiac MRI reviewed after detection of LVHT on postnatal echocardiography and autopsy?","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84779936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Migration: Epidemic Caused by Global Warming and Inequality 移民:全球变暖和不平等造成的流行病
Pub Date : 2018-12-03 DOI: 10.32474/LOJMS.2018.02.000139
R. Skopec
Rising global temperatures may be driving up rates of mental illness as well, a new study suggests. Last year was the third hottest on record, and 2016 was the hottest ever. And more people are struggling with mental health issues in the US now than any other time in the nation’s history. Superior predatory skills led to the evolutionary triumph of jawed vertebrates. However, the mechanisms by which the vertebrate brain controls predation remain largely unknown. Here, we reveal a critical role for the central nucleus of the amygdala in predatory hunting. Both optogenetic and chemo genetic stimulation of central amygdala of mice elicited predatory-like attacks upon both insect and artificial prey. Coordinated control of cervical and mandibular musculatures, which is necessary for accurately positioning lethal bites on prey, was mediated by a central amygdala projection to the reticular formation in the brainstem.
一项新的研究表明,全球气温上升可能也会推高精神疾病的发病率。去年是有记录以来第三热的一年,2016年是有史以来最热的一年。在美国,现在与心理健康问题作斗争的人比美国历史上任何时候都多。高超的捕食技巧使有颌脊椎动物在进化上取得了胜利。然而,脊椎动物大脑控制捕食的机制在很大程度上仍然未知。在这里,我们揭示了杏仁核中央核在掠夺性狩猎中的关键作用。光遗传和化学遗传对小鼠中央杏仁核的刺激均可引起对昆虫和人工猎物的捕食性攻击。颈部和下颌肌肉组织的协调控制是准确定位猎物致命咬伤所必需的,这是由中央杏仁核投射到脑干网状结构所介导的。
{"title":"Migration: Epidemic Caused by Global Warming and Inequality","authors":"R. Skopec","doi":"10.32474/LOJMS.2018.02.000139","DOIUrl":"https://doi.org/10.32474/LOJMS.2018.02.000139","url":null,"abstract":"Rising global temperatures may be driving up rates of mental illness as well, a new study suggests. Last year was the third hottest on record, and 2016 was the hottest ever. And more people are struggling with mental health issues in the US now than any other time in the nation’s history. Superior predatory skills led to the evolutionary triumph of jawed vertebrates. However, the mechanisms by which the vertebrate brain controls predation remain largely unknown. Here, we reveal a critical role for the central nucleus of the amygdala in predatory hunting. Both optogenetic and chemo genetic stimulation of central amygdala of mice elicited predatory-like attacks upon both insect and artificial prey. Coordinated control of cervical and mandibular musculatures, which is necessary for accurately positioning lethal bites on prey, was mediated by a central amygdala projection to the reticular formation in the brainstem.","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87470796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Biotechnology Plays a Significant Role to Control Insect Pests of Agricultural Crops 生物技术在农作物病虫害防治中发挥着重要作用
Pub Date : 2018-11-30 DOI: 10.32474/LOJMS.2018.02.000136
U. Niaz, Burhan Ahmad
Today insect pests have been one of most important problem in food production. Previous research have been proved that 1/3 of agricultural production of world, prized at several billion dollars is ruined by damaging of field and storage insect pests every year. Various toxic, broad-spectrum and synthetic chemicals are used to control pests. Natural ecosystem, human health and our environment can be affected due to excessive use of these harmful chemicals. So now biologically based approaches are developing to control insect pest instead of toxic and synthetic chemicals which are ecofriendly, cost-effective and useful and reliable. There are different types of bio pesticides such as arthropods natural enemies (predators, parasitoids, and parasites), entomopathogens (bacteria, fungi, virus and nematodes), insect hormones and plant derived bio pesticides.
今天,害虫已成为粮食生产中最重要的问题之一。以往的研究已经证明,每年世界上价值数十亿美元的农业生产有三分之一被农田和仓库的害虫破坏。各种有毒的、广谱的和合成的化学品被用来控制害虫。过度使用这些有害化学品会影响自然生态系统、人类健康和我们的环境。因此,目前正在发展以生物为基础的方法来控制害虫,以取代有毒和合成的化学物质,这些化学物质对环境友好,成本低廉,有用且可靠。生物农药有不同类型,如节肢动物的天敌(捕食者、类寄生虫和寄生虫)、昆虫病原体(细菌、真菌、病毒和线虫)、昆虫激素和植物衍生的生物农药。
{"title":"Biotechnology Plays a Significant Role to Control Insect Pests of Agricultural Crops","authors":"U. Niaz, Burhan Ahmad","doi":"10.32474/LOJMS.2018.02.000136","DOIUrl":"https://doi.org/10.32474/LOJMS.2018.02.000136","url":null,"abstract":"Today insect pests have been one of most important problem in food production. Previous research have been proved that 1/3 of agricultural production of world, prized at several billion dollars is ruined by damaging of field and storage insect pests every year. Various toxic, broad-spectrum and synthetic chemicals are used to control pests. Natural ecosystem, human health and our environment can be affected due to excessive use of these harmful chemicals. So now biologically based approaches are developing to control insect pest instead of toxic and synthetic chemicals which are ecofriendly, cost-effective and useful and reliable. There are different types of bio pesticides such as arthropods natural enemies (predators, parasitoids, and parasites), entomopathogens (bacteria, fungi, virus and nematodes), insect hormones and plant derived bio pesticides.","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80272961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Book Review ‘Buku Panduan Kecemasan & Pengurusan Bencana Jabatan Pertahanan Awam Malaysia (Malay Version)
Pub Date : 2018-11-29 DOI: 10.32474/lojms.2018.02.000135
U. Iqbal
{"title":"Book Review ‘Buku Panduan Kecemasan & Pengurusan Bencana Jabatan Pertahanan Awam Malaysia (Malay Version)","authors":"U. Iqbal","doi":"10.32474/lojms.2018.02.000135","DOIUrl":"https://doi.org/10.32474/lojms.2018.02.000135","url":null,"abstract":"","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87149932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3 (Non- Steroidal Anti-Inflammatory Drug (NSAID) 塞来昔布及其非甾体抗炎药(NSAID)多晶型的结晶和多晶可扩展工艺研究
Pub Date : 2018-11-28 DOI: 10.32474/lojms.2018.02.000134
Krishnasarma Pathy, Chakravarthy
The present process provides an improved process for the preparation of 4-[5-(4-methylphenyl)-3(trifluoromethyl)-1Hpyrazol-1-yl] benzene sulfonamide (Celecoxib) and its purification and crystallization to produce polymorph. The present process, which describes the manufacturing process of Celecoxib, which is a nonsteroidal anti-inflammatory drug (NSAID), has the advantage of scaling up to the industrial level of production. The process uses safe reagents in the process which makes it for industrial scale operations. The yields in the process are high, which makes it a cost-effective process. Formation of isomers are less compared with the all existing process, which makes it effective to make it to the pharmacopoeia grade. Residual solvents play a very important role in the impurity profile of APIs as per the ICH Guidelines ICH Q3C (R4). In this process by carrying out the final step of condensation in the aqueous medium followed by crystallization, the residual solvents limits are well taken care of.
本发明提供了一种改进的4-[5-(4-甲基苯基)-3(三氟甲基)-1吡唑-1-基]苯磺酰胺(塞来昔布)的制备及其纯化结晶制备多晶型的工艺。目前的工艺描述了塞来昔布的生产过程,塞来昔布是一种非甾体抗炎药(NSAID),具有扩大到工业生产水平的优势。该工艺过程中使用安全试剂,使其适合工业规模操作。该工艺的产率很高,是一种经济有效的工艺。与所有现有工艺相比,异构体的形成较少,使其有效地达到药典级。根据ICH指南ICH Q3C (R4),残留溶剂在原料药杂质谱中起着非常重要的作用。在这个过程中,通过在水介质中进行最后一步的冷凝,然后是结晶,残余溶剂的限制得到了很好的照顾。
{"title":"Crystallization and Polymorphism-Scalable Process for Celecoxib and It’s Polymorph From-3 (Non- Steroidal Anti-Inflammatory Drug (NSAID)","authors":"Krishnasarma Pathy, Chakravarthy","doi":"10.32474/lojms.2018.02.000134","DOIUrl":"https://doi.org/10.32474/lojms.2018.02.000134","url":null,"abstract":"The present process provides an improved process for the preparation of 4-[5-(4-methylphenyl)-3(trifluoromethyl)-1Hpyrazol-1-yl] benzene sulfonamide (Celecoxib) and its purification and crystallization to produce polymorph. The present process, which describes the manufacturing process of Celecoxib, which is a nonsteroidal anti-inflammatory drug (NSAID), has the advantage of scaling up to the industrial level of production. The process uses safe reagents in the process which makes it for industrial scale operations. The yields in the process are high, which makes it a cost-effective process. Formation of isomers are less compared with the all existing process, which makes it effective to make it to the pharmacopoeia grade. Residual solvents play a very important role in the impurity profile of APIs as per the ICH Guidelines ICH Q3C (R4). In this process by carrying out the final step of condensation in the aqueous medium followed by crystallization, the residual solvents limits are well taken care of.","PeriodicalId":18057,"journal":{"name":"LOJ Medical Sciences","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88328184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
LOJ Medical Sciences
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1