Pub Date : 2021-10-01DOI: 10.31674/mjmr.2021.v05i04.002
N. Indika, Nirmalie Gayathrie Fonseka
The addition of methylene blue to the standard treatment protocol has been shown to improve respiratory rate and oxygen saturation in COVID-19 patients, reducing morbidity and mortality. Evidence to date suggests that methylene blue inhibits protein-protein interactions between SARS-CoV-2 Spike protein and angiotensin-converting enzyme 2, which in turn inhibits the cell entry of SARS-CoV-2. However, the methylene blue dye-binding characteristics of sulfated glycosaminoglycans suggest additional inhibitory effects of the spike protein-heparan sulfate interaction. We hypothesize that the binding of cationic methylene blue neutralizes polyanionic heparan sulfate molecules on the host cell surface. As a consequence, electrostatic interactions between negatively charged heparan sulfate and the positively charged receptor binding domain of SARS-CoV-2 spike protein will be inhibited. Thus, methylene blue will exhibit a "shielding effect" on the heparan sulfate proteoglycans, inhibiting viral attachment to the cell surface. The proposed mechanism corroborates the possible broad-spectrum antiviral activity of methylene blue against multiple human coronaviruses that exploit the electrostatic interactions with sulfated glycosaminoglycans for virus entry. Methylene blue would exhibit the same anti-adhesive activity at the blood-brain-barrier and olfactory neuroepithelium, corroborating potential benefits in ameliorating post-COVID-19 neurological impairment. However, as cationic dyes can bind to both free glycosaminoglycans in circulation as well as proteoglycans attached to the cell surface, co-administration of intravenous heparin could possibly antagonize the proposed antiviral activity. This critical review focuses on empirical evidence to support the hypothesized heparan sulfate-dependent antiviral activity of MB.
{"title":"METHYLENE BLUE INHIBITS THE INTERACTION BETWEEN HEPARAN SULFATE AND SARS-COV-2 SPIKE PROTEIN; A REVIEW OF EVIDENCE FOR A HYPOTHESIS.","authors":"N. Indika, Nirmalie Gayathrie Fonseka","doi":"10.31674/mjmr.2021.v05i04.002","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i04.002","url":null,"abstract":"The addition of methylene blue to the standard treatment protocol has been shown to improve respiratory rate and oxygen saturation in COVID-19 patients, reducing morbidity and mortality. Evidence to date suggests that methylene blue inhibits protein-protein interactions between SARS-CoV-2 Spike protein and angiotensin-converting enzyme 2, which in turn inhibits the cell entry of SARS-CoV-2. However, the methylene blue dye-binding characteristics of sulfated glycosaminoglycans suggest additional inhibitory effects of the spike protein-heparan sulfate interaction. We hypothesize that the binding of cationic methylene blue neutralizes polyanionic heparan sulfate molecules on the host cell surface. As a consequence, electrostatic interactions between negatively charged heparan sulfate and the positively charged receptor binding domain of SARS-CoV-2 spike protein will be inhibited. Thus, methylene blue will exhibit a \"shielding effect\" on the heparan sulfate proteoglycans, inhibiting viral attachment to the cell surface. The proposed mechanism corroborates the possible broad-spectrum antiviral activity of methylene blue against multiple human coronaviruses that exploit the electrostatic interactions with sulfated glycosaminoglycans for virus entry. Methylene blue would exhibit the same anti-adhesive activity at the blood-brain-barrier and olfactory neuroepithelium, corroborating potential benefits in ameliorating post-COVID-19 neurological impairment. However, as cationic dyes can bind to both free glycosaminoglycans in circulation as well as proteoglycans attached to the cell surface, co-administration of intravenous heparin could possibly antagonize the proposed antiviral activity. This critical review focuses on empirical evidence to support the hypothesized heparan sulfate-dependent antiviral activity of MB.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90426037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.31674/mjmr.2021.v05i04.006
Mohd Aznan Md Aris, Mazilah Mazlan, N. S. K. Roslee
HYDRONEPHROSIS: A CASE OF URETERAL METASTASIS OF PROSTATE CANCER
肾积水:前列腺癌输尿管转移1例
{"title":"HYDRONEPHROSIS: A CASE OF URETERAL METASTASISOF PROSTATE CANCER","authors":"Mohd Aznan Md Aris, Mazilah Mazlan, N. S. K. Roslee","doi":"10.31674/mjmr.2021.v05i04.006","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i04.006","url":null,"abstract":"HYDRONEPHROSIS: A CASE OF URETERAL METASTASIS OF PROSTATE CANCER","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"284 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77178800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.31674/mjmr.2021.v05i04.003
Syazana Aqilah Zulkifli, M. Aris
This report illustrates a case of a 60-year-old lady with type 2 diabetes mellitus who performs intermittent fasting (IF) diet, with the aim to lose her weight and indirectly reverse her diabetes mellitus, hypertension, and hyperlipidaemia. She managed to get the optimum blood pressure, lose 6 kg, and reduce her glycaemic control from 7.8% to 5.8% within 10 months period. However, she started to get episodes of symptomatic post prandial hypoglycaemia when she is about to achieve her target.
{"title":"A CASE REPORT: POSTPRANDIAL HYPOGLYCAEMIA IN INTERMITTENT FASTING DIET FOR TYPE 2 DIABETES MELLITUS PATIENT","authors":"Syazana Aqilah Zulkifli, M. Aris","doi":"10.31674/mjmr.2021.v05i04.003","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i04.003","url":null,"abstract":"This report illustrates a case of a 60-year-old lady with type 2 diabetes mellitus who performs intermittent fasting (IF) diet, with the aim to lose her weight and indirectly reverse her diabetes mellitus, hypertension, and hyperlipidaemia. She managed to get the optimum blood pressure, lose 6 kg, and reduce her glycaemic control from 7.8% to 5.8% within 10 months period. However, she started to get episodes of symptomatic post prandial hypoglycaemia when she is about to achieve her target.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88286253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers that are validated and robust are required for the enhancement of diagnosis, the observation of drug-related activity, therapeutic reactions, and as the blueprint for developing safer and more direct therapeutic efforts for a variety of chronic ailments. Various kinds of biomarkers have proven impactful when it comes to the discovery and development of drugs, but the procedure that involves identifying and verifying ailment-specific biomarkers has proven to be hassling. In recent times, there have been some advancements in multiple omics (also known as multi-omics) methods like transcriptomic, cytometry, genomics, proteomics, metabolomics and imaging. These advancements have made it possible for the discovery and development of distinct biomarkers for complicated chronic ailments to be accelerated expeditiously. In spite of the fact that numerous drawbacks still need to be looked into, ongoing efforts for the discovery and improvement of illness-associated biomarkers will go a long way in optimizing decision-making across the entire process of drug development and expand our comprehension of the infection processes. In addition, when the preclinical biomarkers are effectively translated into the clinic, the way will pave well to an equally effective implementation of personalized therapies throughout complicated illness environments to become beneficial to patients, healthcare service providers and the industry of bio-pharma.
{"title":"Biomarkers and Bioactivity in Drug Discovery using a Joint Modelling Approach","authors":"Kawsher Rahman","doi":"10.18034/mjmbr.v8i2.585","DOIUrl":"https://doi.org/10.18034/mjmbr.v8i2.585","url":null,"abstract":"Biomarkers that are validated and robust are required for the enhancement of diagnosis, the observation of drug-related activity, therapeutic reactions, and as the blueprint for developing safer and more direct therapeutic efforts for a variety of chronic ailments. Various kinds of biomarkers have proven impactful when it comes to the discovery and development of drugs, but the procedure that involves identifying and verifying ailment-specific biomarkers has proven to be hassling. In recent times, there have been some advancements in multiple omics (also known as multi-omics) methods like transcriptomic, cytometry, genomics, proteomics, metabolomics and imaging. These advancements have made it possible for the discovery and development of distinct biomarkers for complicated chronic ailments to be accelerated expeditiously. In spite of the fact that numerous drawbacks still need to be looked into, ongoing efforts for the discovery and improvement of illness-associated biomarkers will go a long way in optimizing decision-making across the entire process of drug development and expand our comprehension of the infection processes. In addition, when the preclinical biomarkers are effectively translated into the clinic, the way will pave well to an equally effective implementation of personalized therapies throughout complicated illness environments to become beneficial to patients, healthcare service providers and the industry of bio-pharma. \u0000 ","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74774660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, there has been an uptick in interest in generative models for molecules in drug development. In the field of de novo molecular design, these models are used to make molecules with desired properties from scratch. This is occasionally used instead of virtual screening, which is limited by the size of the libraries that can be searched in practice. Rather than screening existing libraries, generative models can be used to build custom libraries from scratch. Using generative models, which may optimize molecules straight towards the desired profile, this time-consuming approach can be sped up. The purpose of this work is to show how current shortcomings in evaluating generative models for molecules can be avoided. We cover both distribution-learning and goal-directed generation with a focus on the latter. Three well-known targets were downloaded from ChEMBL: Janus kinase 2 (JAK2), epidermal growth factor receptor (EGFR), and dopamine receptor D2 (DRD2) (Bento et al. 2014). We preprocessed the data to get binary classification jobs. Before calculating a scoring function, the data is split into two halves, which we shall refer to as split 1/2. The ratio of active to inactive users. Our goal is to train three bioactivity models with equal prediction performance, one to be used as a scoring function for chemical optimization and the other two to be used as performance evaluation models. Our findings suggest that distribution-learning can attain near-perfect scores on many existing criteria even with the most basic and completely useless models. According to benchmark studies, likelihood-based models account for many of the best technologies, and we propose that test set likelihoods be included in future comparisons.
近年来，人们对药物开发中的分子生成模型的兴趣有所上升。在从头分子设计领域，这些模型用于从零开始制造具有所需性质的分子。这偶尔会被用来代替虚拟筛选，因为虚拟筛选在实践中受限于可搜索的库的大小。生成模型可以用来从头开始构建自定义库，而不是筛选现有库。使用生成模型，它可以直接优化分子到所需的轮廓，这种耗时的方法可以加快速度。这项工作的目的是展示如何在评估分子生成模型目前的缺点可以避免。我们涵盖了分布学习和目标导向生成，重点是后者。从ChEMBL下载了三个众所周知的靶点:Janus激酶2 (JAK2)、表皮生长因子受体(EGFR)和多巴胺受体D2 (DRD2) (Bento et al. 2014)。我们对数据进行预处理以获得二元分类作业。在计算评分函数之前，将数据分成两半，我们称之为二分之一。活跃用户与非活跃用户的比率。我们的目标是训练三个具有相同预测性能的生物活性模型，其中一个用作化学优化的评分函数，另外两个用作性能评估模型。我们的研究结果表明，即使使用最基本和完全无用的模型，分布学习也可以在许多现有标准上获得近乎完美的分数。根据基准研究，基于似然的模型解释了许多最好的技术，我们建议在未来的比较中包括测试集似然。
{"title":"Molecular Generators and Optimizers Failure Modes","authors":"Mani Manavalan","doi":"10.18034/mjmbr.v8i2.583","DOIUrl":"https://doi.org/10.18034/mjmbr.v8i2.583","url":null,"abstract":"In recent years, there has been an uptick in interest in generative models for molecules in drug development. In the field of de novo molecular design, these models are used to make molecules with desired properties from scratch. This is occasionally used instead of virtual screening, which is limited by the size of the libraries that can be searched in practice. Rather than screening existing libraries, generative models can be used to build custom libraries from scratch. Using generative models, which may optimize molecules straight towards the desired profile, this time-consuming approach can be sped up. The purpose of this work is to show how current shortcomings in evaluating generative models for molecules can be avoided. We cover both distribution-learning and goal-directed generation with a focus on the latter. Three well-known targets were downloaded from ChEMBL: Janus kinase 2 (JAK2), epidermal growth factor receptor (EGFR), and dopamine receptor D2 (DRD2) (Bento et al. 2014). We preprocessed the data to get binary classification jobs. Before calculating a scoring function, the data is split into two halves, which we shall refer to as split 1/2. The ratio of active to inactive users. Our goal is to train three bioactivity models with equal prediction performance, one to be used as a scoring function for chemical optimization and the other two to be used as performance evaluation models. Our findings suggest that distribution-learning can attain near-perfect scores on many existing criteria even with the most basic and completely useless models. According to benchmark studies, likelihood-based models account for many of the best technologies, and we propose that test set likelihoods be included in future comparisons.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84675440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morgellons disease is a distressing dermatologic condition that typically presents with multiple, non-healing skin lesions with filamentous protrusions. Initial presentation of the condition can often include various neurological symptoms with dermatologic symptoms. Common neurological symptoms include neuropathy, cognitive impairment, and dementia. Recent studies reveal that spirochetes are a causative agent of Morgellons disease. Chronic spirochete infection is strongly associated with neurodegeneration seen in dementia and Alzheimer’s disease. This paper will provide a brief overview of Morgellons and Alzheimer’s disease and will explore the possible risk of developing Alzheimer’s in Morgellons patients.
{"title":"Risk of Neurodegeneration in Patients with Morgellons Disease: A Focus on the Potential Risk of Developing Alzheimer’s","authors":"J. Grimm","doi":"10.18034/mjmbr.v8i2.579","DOIUrl":"https://doi.org/10.18034/mjmbr.v8i2.579","url":null,"abstract":"Morgellons disease is a distressing dermatologic condition that typically presents with multiple, non-healing skin lesions with filamentous protrusions. Initial presentation of the condition can often include various neurological symptoms with dermatologic symptoms. Common neurological symptoms include neuropathy, cognitive impairment, and dementia. Recent studies reveal that spirochetes are a causative agent of Morgellons disease. Chronic spirochete infection is strongly associated with neurodegeneration seen in dementia and Alzheimer’s disease. This paper will provide a brief overview of Morgellons and Alzheimer’s disease and will explore the possible risk of developing Alzheimer’s in Morgellons patients.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77686898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.31674/mjmr.2021.v05i03.006
N. Anggraini
Introduction: Diabetes mellitus is a metabolic disease most often occurs in the elderly due to decreased function of the pancreas which produce insulin function. The number of elderly patients with DM in the village of Tell subdistrict of Sidoarjo regency Sukodono ignorance alternative ways to control blood sugar levels. The purpose of this study was to analyze the influence of herbal therapy steeping Salam leaves against a decrease in blood glucose levels in the elderly. Methods:This study design pre Experiment (One-group pre-post test design). Samples were taken using purposive sampling and obtained as many as 28 elderly Tell Rural District of Sukodono Sidoarjo. The independent variable is the herbal therapy steeping Salam leaves and the dependent variable is blood glucose levels in the elderly. Test Gluchose research instruments used for the measurement of blood sugar levels. Test data analysis using Paired T-test ? ? 0.05. Results:The results showed that the steeping Salam leaves for lowering blood glucose levels in elderly people with diabetes mellitus is evidenced by the results of Test Paired t-test showed ? = 0.000 before and after the treatment groups. Conclution:Seeing the results of this study can be concluded that the steeping Salam leaves containing astringent compounds can affect insulin sensitivity thereby stimulating the parasympathetic autonomic nerve stimulation and stimulate the release of insulin from the pancreas gland. Furthermore, the public are advised to be used as an alternative way to control blood sugar levels.
{"title":"EFFECT OF HERBAL THERAPY STEEPING SALAM LEAF TO DECREASE IN BLOOD GLUCOSE LEVELS IN ELDERLY PATIENTS WITH DIABETES MELLITUS IN THE VILLAGE OF SUKODONO SUBDISTRICT OF SIDOARJO CITY","authors":"N. Anggraini","doi":"10.31674/mjmr.2021.v05i03.006","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.006","url":null,"abstract":"Introduction: Diabetes mellitus is a metabolic disease most often occurs in the elderly due to decreased function of the pancreas which produce insulin function. The number of elderly patients with DM in the village of Tell subdistrict of Sidoarjo regency Sukodono ignorance alternative ways to control blood sugar levels. The purpose of this study was to analyze the influence of herbal therapy steeping Salam leaves against a decrease in blood glucose levels in the elderly. Methods:This study design pre Experiment (One-group pre-post test design). Samples were taken using purposive sampling and obtained as many as 28 elderly Tell Rural District of Sukodono Sidoarjo. The independent variable is the herbal therapy steeping Salam leaves and the dependent variable is blood glucose levels in the elderly. Test Gluchose research instruments used for the measurement of blood sugar levels. Test data analysis using Paired T-test ? ? 0.05. Results:The results showed that the steeping Salam leaves for lowering blood glucose levels in elderly people with diabetes mellitus is evidenced by the results of Test Paired t-test showed ? = 0.000 before and after the treatment groups. Conclution:Seeing the results of this study can be concluded that the steeping Salam leaves containing astringent compounds can affect insulin sensitivity thereby stimulating the parasympathetic autonomic nerve stimulation and stimulate the release of insulin from the pancreas gland. Furthermore, the public are advised to be used as an alternative way to control blood sugar levels.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87482267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.31674/mjmr.2021.v05i03.005
Sumaiyah Abdul Aziz
Hospitalized patients are often prescribed with antibiotics and it can be a challenge for the prescriber. This study is conducted to review the prescribing pattern of intravenous antibiotics for hospitalized patients in Jerantut Hospital in accordance to the National Antibiotic Guideline and Antimicrobial Stewardship Program.
{"title":"PRESCRIBING PATTERN OF INTRAVENOUS ANTIBIOTICS FOR HOSPITALIZED PATIENT IN HOSPITAL JERANTUT","authors":"Sumaiyah Abdul Aziz","doi":"10.31674/mjmr.2021.v05i03.005","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.005","url":null,"abstract":"Hospitalized patients are often prescribed with antibiotics and it can be a challenge for the prescriber. This study is conducted to review the prescribing pattern of intravenous antibiotics for hospitalized patients in Jerantut Hospital in accordance to the National Antibiotic Guideline and Antimicrobial Stewardship Program.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72902669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.31674/mjmr.2021.v05i03.002
D. Hartono, U. A. Hidayat, Y. Cahyati, Sandeep Poddar
Anxiety is the most common mental disorder, around 3.6% of the population. Effective care and treatment for anxiety disorders are needed. This is done so that individuals who experience these disorders can return to being productive in meeting their life needs and do not depend on other people. Currently, client management is not only given psychopharmaceutical treatment but also with a psychotherapy approach. This study aims to determine the integrative effect of five-finger hypnosis and aromatherapy on the level of anxiety of patients at the Mental Polyclinic of dr. Soekardjo City of Tasikmalaya. The method used is research quantitative with research quasi-experimental design pre-test and post-test with control design. Bivariate analysis on the variables before and after the intervention using paired t-test, and independent t-test to see the comparison of anxiety scores after intervention in the control group and the intervention group. The results showed 60 respondents, 30 control group respondents received Five Finger Hypnosis treatment for 4 times a week for 3 weeks, while 30 people in the intervention group received a combination of Five Finger Hypnosis and Aromatherapy for 4 times a week for 3 weeks. Before and after the intervention was carried out, the level of anxiety was measured using the Hamilton Anxiety Rating Scale (HARS). The analysis showed that there was a difference in the average score of anxiety before and after the intervention in the intervention group. Further analysis found that there was a significant difference in the average score of anxiety after the intervention between the control group and the intervention group. therapy Five finger hypnosis and aromatherapy should be used as an independent nursing intervention in dealing with anxiety problems.
{"title":"REDUCING ANXIETY LEVELS THROUGH INTEGRATIVE INTERVENTION OF FIVE-FINGER HYPNOSIS AND AROMATHERAPY","authors":"D. Hartono, U. A. Hidayat, Y. Cahyati, Sandeep Poddar","doi":"10.31674/mjmr.2021.v05i03.002","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.002","url":null,"abstract":"Anxiety is the most common mental disorder, around 3.6% of the population. Effective care and treatment for anxiety disorders are needed. This is done so that individuals who experience these disorders can return to being productive in meeting their life needs and do not depend on other people. Currently, client management is not only given psychopharmaceutical treatment but also with a psychotherapy approach. \u0000\u0000This study aims to determine the integrative effect of five-finger hypnosis and aromatherapy on the level of anxiety of patients at the Mental Polyclinic of dr. Soekardjo City of Tasikmalaya. The method used is research quantitative with research quasi-experimental design pre-test and post-test with control design. Bivariate analysis on the variables before and after the intervention using paired t-test, and independent t-test to see the comparison of anxiety scores after intervention in the control group and the intervention group.\u0000\u0000The results showed 60 respondents, 30 control group respondents received Five Finger Hypnosis treatment for 4 times a week for 3 weeks, while 30 people in the intervention group received a combination of Five Finger Hypnosis and Aromatherapy for 4 times a week for 3 weeks. Before and after the intervention was carried out, the level of anxiety was measured using the Hamilton Anxiety Rating Scale (HARS). The analysis showed that there was a difference in the average score of anxiety before and after the intervention in the intervention group. Further analysis found that there was a significant difference in the average score of anxiety after the intervention between the control group and the intervention group. therapy Five finger hypnosis and aromatherapy should be used as an independent nursing intervention in dealing with anxiety problems.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91124113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-01DOI: 10.31674/mjmr.2021.v05i03.003
Dior Manta Tambunan, N. Nurjanah, S. Rahmayanti, Rahmi Imelisa, F. M. Said, Bibi Florina Abdullah
Background: Coronavirus pandemic represents a huge threat and phenomenal risks on mental and emotional wellness among children. This systematic review expects to integrate academic research literature that provides details regarding the impact of COVID-19 on emotional wellbeing and mental status among children. Methods: A systematic research engine was escorted on PubMed, Proquest, ScienceDirect, and Google Scholar with keywords: Children, COVID-19, Mental Status, Psychological Status from December 2019 to 18 November 2020 following the PRISMA guidelines. Articles were chosen dependent on the predetermined eligibility criteria. The included articles to review used the Quality Assessment Tool Adapted from the National Institutes of Health (NIH). Results: A total of 17,059 records were identified using the keywords. After removal of duplicates and initial screening, seven articles met the inclusion criteria of COVID-19 influence on mental and emotional wellbeing among children. The research design was a longitudinal and cross-sectional online survey with the children age range was 3 – 18 years old. Conclusions: COVID-19 Pandemic has a significant influence on mental and emotional wellbeing among children. Some children experienced depressive indication, difficulty concentrating, anxiety, touchy and easy to get irritated. Limitations: Online survey generalized the results, younger children might need assistance from parents during filling up the questionnaire, small sampling size.
{"title":"IMPACT OF COVID-19 PANDEMIC ON MENTAL AND EMOTIONAL WELLBEING AMONG CHILDREN: A SYSTEMATIC REVIEW","authors":"Dior Manta Tambunan, N. Nurjanah, S. Rahmayanti, Rahmi Imelisa, F. M. Said, Bibi Florina Abdullah","doi":"10.31674/mjmr.2021.v05i03.003","DOIUrl":"https://doi.org/10.31674/mjmr.2021.v05i03.003","url":null,"abstract":"Background: Coronavirus pandemic represents a huge threat and phenomenal risks on mental and emotional wellness among children. This systematic review expects to integrate academic research literature that provides details regarding the impact of COVID-19 on emotional wellbeing and mental status among children.\u0000\u0000Methods: A systematic research engine was escorted on PubMed, Proquest, ScienceDirect, and Google Scholar with keywords: Children, COVID-19, Mental Status, Psychological Status from December 2019 to 18 November 2020 following the PRISMA guidelines. Articles were chosen dependent on the predetermined eligibility criteria. The included articles to review used the Quality Assessment Tool Adapted from the National Institutes of Health (NIH).\u0000\u0000Results: A total of 17,059 records were identified using the keywords. After removal of duplicates and initial screening, seven articles met the inclusion criteria of COVID-19 influence on mental and emotional wellbeing among children. The research design was a longitudinal and cross-sectional online survey with the children age range was 3 – 18 years old.\u0000\u0000Conclusions: COVID-19 Pandemic has a significant influence on mental and emotional wellbeing among children. Some children experienced depressive indication, difficulty concentrating, anxiety, touchy and easy to get irritated.\u0000\u0000Limitations: Online survey generalized the results, younger children might need assistance from parents during filling up the questionnaire, small sampling size.","PeriodicalId":18105,"journal":{"name":"Malaysian Journal of Medical and Biological Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76926695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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