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Medical education in Libya: Challenges, hopes, and recommendations 利比亚的医学教育:挑战、希望和建议
Pub Date : 2019-01-01 DOI: 10.4103/LIUJ.LIUJ_3_19
A. Al-areibi
The purpose of this review is to examine the current Libyan medical education system, look at its positive and negative aspects, and to provide suggestions and recommendations that could help improve the quality of the system today. The current Libyan medical education system has aged, and unfortunately, cannot meet both societal needs and the new requirements from the World Federation of Medical Education (WFME). The WFME issued a strong statement to all international medical schools to meet its new accreditation standards by 2023 in order for them to be recognized internationally. Lacking almost 70% of the international standards, Libyan medical schools will require considerable amount of time and resources to solve the issue. The process of changing and updating the system will involve all parts of the learning environment, including students, teachers, curriculums, resources, research, and governing bodies.
这次审查的目的是检查当前利比亚医学教育系统,看看其积极和消极的方面,并提供建议和建议,可以帮助提高今天的系统质量。目前利比亚的医学教育系统已经老化,不幸的是,不能满足社会需求和世界医学教育联合会(WFME)的新要求。世界医学联合会发表了一份强烈声明,要求所有国际医学院在2023年之前达到新的认证标准,以便得到国际承认。利比亚医学院缺乏近70%的国际标准,将需要相当多的时间和资源来解决这个问题。改变和更新系统的过程将涉及学习环境的各个方面,包括学生、教师、课程、资源、研究和管理机构。
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引用次数: 4
Exploring the relationship between air pollution and health of children: A global perspective 探讨空气污染与儿童健康之间的关系:全球视角
Pub Date : 2019-01-01 DOI: 10.4103/liuj.liuj_4_19
S. Shrivastava, P. Shrivastava
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引用次数: 0
Ensuring strengthening and expansion of the prevention and control activities for the elimination of hepatitis C 确保加强和扩大预防和控制活动,以消除丙型肝炎
Pub Date : 2019-01-01 DOI: 10.4103/liuj.liuj_36_18
S. Shrivastava, P. Shrivastava
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引用次数: 0
Determination of some heavy metals in cosmetic products collected from Benghazi-Libya markets during 2016 2016年班加西-利比亚市场化妆品中重金属含量测定
Pub Date : 2019-01-01 DOI: 10.4103/LIUJ.LIUJ_44_18
Salwa Rahil, Intisar A. Elshara, N. Ahmida, M. Ahmida
Introduction: Cosmetics have been utilized by most of the people irrespective of their race, gender, or age to beautify, modify, or improve the physical appearance. Many cosmetic products contain heavy metals as ingredients or impurities. Recent research has reported that these metals can cause many types of health and skin problems. Aims: The aim of this study is to detect the levels of heavy metals in some cosmetic products that are available in cosmetic shops around the city of Benghazi. Materials and Methods: Twenty-five of cheap facial cosmetic products that are widely in demand in cosmetic shops in Benghazi were collected in April 2016. The samples included eight kohl, seven eyeliners, and ten lipsticks. Metals including iron, copper, chromium, zinc, lead, and cadmium were analyzed in the selected samples using flame atomic absorption spectrophotometer after suitable digestion process. Results: Our results indicated that iron and copper were detected in all samples with concentration ranges varying from 0.5 to 124.5 mg/kg for iron and 1.8–51.4 mg/kg for copper. The concentration ranges of chromium, zinc, cadmium, and lead were varied from 0.0 to 7.25 mg/kg, 0.0 to 22.75, 0.0 to 125.0 mg/kg, and 0.0 to 20.25 mg/kg, respectively. Conclusions: The results showed that the selected metals were detected in most of the samples at varying concentrations. Kohl samples have the highest concentration of the analyzed metals. According to the maximum allowed limits recommended by the World Health Organization (WHO) for toxic metals in cosmetics, there was only one sample that had lead concentration higher than the maximum limit recommended by the WHO. In addition, there were twenty samples that had concentrations of cadmium above the WHO legislation limits.
化妆品已经被大多数人使用,不管他们的种族、性别或年龄,来美化、修饰或改善外表。许多化妆品含有重金属成分或杂质。最近的研究报告称,这些金属会导致多种健康和皮肤问题。目的:本研究的目的是检测在班加西市化妆品商店出售的一些化妆品中的重金属含量。材料与方法:于2016年4月收集班加西地区化妆品商店中需求量较大的25种廉价面部化妆品。这些样品包括8个眼影粉、7个眼线笔和10支口红。选择样品,经过适当的消化处理,用火焰原子吸收分光光度计对铁、铜、铬、锌、铅、镉等金属进行分析。结果:所有样品中均检测到铁和铜,铁的浓度范围为0.5 ~ 124.5 mg/kg,铜的浓度范围为1.8 ~ 51.4 mg/kg。铬、锌、镉、铅的浓度范围分别为0.0 ~ 7.25 mg/kg、0.0 ~ 22.75 mg/kg、0.0 ~ 125.0 mg/kg和0.0 ~ 20.25 mg/kg。结论:所选金属在不同浓度下均可检出。科尔样品中所分析金属的浓度最高。根据世界卫生组织(WHO)规定的化妆品中有毒金属的最大允许限量,只有一个样品的铅浓度超过了WHO规定的最大允许限量。此外,有20个样品的镉浓度超过了世界卫生组织的立法限制。
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引用次数: 2
Preventing newborn deaths in marginalized population groups 预防边缘人口群体的新生儿死亡
Pub Date : 2019-01-01 DOI: 10.4103/liuj.liuj_48_18
S. Shrivastava, P. Shrivastava
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引用次数: 0
Childhood tuberculosis in a South-East Nigerian tertiary hospital: Treatment outcomes and determinants 尼日利亚东南部一家三级医院的儿童结核病:治疗结果和决定因素
Pub Date : 2019-01-01 DOI: 10.4103/LIUJ.LIUJ_47_18
C. Onubogu, E. Ugochukwu, A. Anyabolu, J. Ojukwu
Background and Objectives: Tuberculosis (TB) is an important cause of childhood morbidity and mortality. Understanding the barriers to successful childhood TB treatment is vital to curbing the scourge of childhood TB. This study examined the outcomes and factors that influence the outcomes of childhood TB treatment in a South-East Nigerian tertiary hospital. Methods: A 10-year review of the medical records of under-15 year olds, who received anti-TB treatment at Nnamdi Azikiwe University Teaching Hospital, Nnewi, was carried out. Data were analyzed using SPSS version 20. Results: Majority of the 501 childhood TB cases were new (89.6%) and pulmonary (73.3%) TB cases. TB-HIV coinfection occurred in 42.5% of cases. The rate of successful treatment was 62.9%. About 57.5% completed treatment, 5.4% were cured, 7.0% were transferred out, 21.4% were lost to follow-up, 0.4% had treatment failure while 8.4% died. Majority (61.6%) of deaths or loss to follow-up occurred during the first 2 months of treatment. Factors significantly associated with treatment outcomes were ascertainment of HIV status (P = 0.049), disease site (P = 0.013), nutritional status (P = 0.039), Mantoux test result (P = 0.002), and period of treatment (P = 0.005). Conclusion: Findings indicate high rate of unsuccessful childhood TB treatment outcomes. Efforts should be intensified to ensure improved outcomes through proactive search for childhood TB cases, early diagnosis and treatment, as well as adherence to and completion of treatment. Special attention should be given to high-risk groups including those with unknown HIV status, extrapulmonary TB, and severe malnutrition. It is imperative to determine the HIV status of all childhood TB cases.
背景和目的:结核病(TB)是儿童发病和死亡的重要原因。了解成功治疗儿童结核病的障碍对于遏制儿童结核病的祸害至关重要。本研究调查了影响尼日利亚东南部一家三级医院儿童结核病治疗结果的结果和因素。方法:对在Nnewi Nnamdi Azikiwe大学教学医院接受抗结核治疗的15岁以下儿童的10年医疗记录进行回顾。数据分析采用SPSS version 20。结果:501例儿童结核以新发结核(89.6%)和肺结核(73.3%)为主。42.5%的病例发生结核-艾滋病毒合并感染。治疗成功率为62.9%。治愈率为57.5%,治愈率为5.4%,转院率为7.0%,失访率为21.4%,治疗失败率为0.4%,死亡率为8.4%。大多数(61.6%)死亡或失去随访发生在治疗的前2个月。与治疗结果有显著相关的因素包括HIV感染状况(P = 0.049)、疾病部位(P = 0.013)、营养状况(P = 0.039)、Mantoux检测结果(P = 0.002)和治疗时间(P = 0.005)。结论:研究结果表明儿童结核病治疗失败率高。应加强努力,确保通过积极寻找儿童结核病病例、早期诊断和治疗以及坚持和完成治疗来改善结果。应特别注意高危人群,包括艾滋病毒感染状况未知的人群、肺外结核患者和严重营养不良患者。必须确定所有儿童结核病例的艾滋病毒感染状况。
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引用次数: 0
The redesign of amoxicillin capsules as a tablet dosage form using direct compression 重新设计阿莫西林胶囊作为片剂剂型使用直接压缩
Pub Date : 2019-01-01 DOI: 10.4103/LIUJ.LIUJ_45_18
Salem Elgahmi, Nawal Alrishei, Rabeaa Algaraboly, Aisha Altrablesy, I. El-Mahdi
Introduction: Solid dosage forms are the most commonly used dosage form for drug delivery, and tablets are more popular than capsules because of its lower production cost, minimal potential of content tampering, and the large number of designs of tablets for various applications. Aims: The aim of this work is to redesign amoxicillin hard gelatin capsules (HGCs), commonly filled into HGCs, into tablet dosage form by employing preformulation principles. Materials and Methods: Amoxicillin capsules were obtained from the local market for this purpose. Experiments included studies on flowability and effect of compression force, followed by addition of excipients, production of tablets by direct compression, and evaluation employing standard methods of friability, hardness, disintegration, dissolution, and simulation of release kinetics. Results: The flowability of powder was estimated using Carr's index, Hausner ratio, angle of repose, and bulk density. The flowability was found poor for amoxicillin alone or with starch but improved with talc. Compression force was found to be a significant factor on friability, hardness, and disintegration. The disintegration time was rapid in case of tablets containing starch compared to amoxicillin powder compressed alone. It was essential to include small amounts of disintegrant and a lubricant to optimize tablet properties. Dissolution rates for the prepared tablets were found to be acceptable, while some formulations showed a slow release profiles corresponding to their slow disintegration. Release kinetics was found to follow both the zero-order and matrix models. Conclusion: Amoxicillin capsules can be modified to a tablet dosage form with simple handling of preformulation properties.
简介:固体剂型是最常用的给药剂型,片剂比胶囊更受欢迎,因为它的生产成本更低,内容物篡改的可能性最小,片剂的设计数量多,适用于各种应用。目的:采用预制剂原理,将阿莫西林硬明胶胶囊(hgc)重新设计成片剂剂型。材料和方法:阿莫西林胶囊从当地市场获得。实验包括流动性和压缩力影响的研究,随后加入辅料,直接压缩生产片剂,采用标准的脆度、硬度、崩解、溶出度评价方法,并模拟释放动力学。结果:用卡尔指数、豪斯纳比、休止角、堆积密度等指标评价粉末的流动性。阿莫西林单独使用或与淀粉一起使用时流动性较差,而滑石粉可改善流动性。压缩力是影响脆性、硬度和崩解的重要因素。淀粉片的崩解时间比单独压缩阿莫西林粉剂快。为了优化片剂的性能,必须加入少量的崩解剂和润滑剂。所制备的片剂溶出率是可以接受的,而有些制剂则表现出与其缓慢崩解相对应的缓释特征。释放动力学遵循零阶和矩阵模型。结论:阿莫西林胶囊可制成片剂剂型,且制剂性质处理简单。
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引用次数: 1
The physical, chemical, and microbiological stability of chloramphenicol ophthalmic solution 氯霉素眼药水的物理、化学和微生物稳定性
Pub Date : 2018-07-01 DOI: 10.4103/LIUJ.LIUJ_16_18
Tauwfik M. Salih, I. El-Mahdi
Aims: The aim of this work is to “predict” the remaining shelf-life of chloramphenicol (CH) eye drops, commercially marketed, using the theoretical “Longland–Rowbotham model,”” followed by confirmation of findings by practical means. Materials and Methods: The methods used for the evaluation of CH-eye drops included the assay of the active ingredient, sterility testing, and minimum inhibitory concentration (MIC) determination using official methods during 6 months stability study at variable temperatures (4, 25°C). Furthermore, a 3-month accelerated stability study was carried out. Statistical analysis tests included Student's t-test and analysis of variance. Results: The prediction model indicated that in pessimistic conditions, the remaining shelf life was reduced to a merely 1 month following production (this is versus the 2 years expiration date given by manufacturer). However, the samples analyzed throughout a 6-month stability study revealed that storing CH solution at 4°C or 25°C does not produce any statistical difference regarding drug content, MIC, or sterility. Accelerated stability studies for 3 months period showed that only after 2 months from storage at 55°C the drug will start to degrade and a statistical difference could be observed. Conclusion: Storing CH-eye drops at room temperature for up to 6 months appears to have no effect on the stability of this antibiotic.
目的:这项工作的目的是“预测”氯霉素(CH)滴眼液的剩余保质期,使用理论的“朗兰-罗博瑟姆模型”,然后通过实际手段确认研究结果。材料与方法:对ch -滴眼液进行评价的方法包括:在6个月的变温(4,25°C)稳定性研究中,采用官方方法进行有效成分测定、无菌试验和最低抑制浓度(MIC)测定。此外,进行了为期3个月的加速稳定性研究。统计分析检验包括学生t检验和方差分析。结果:预测模型表明,在悲观的条件下,剩余的保质期在生产后仅减少到1个月(而不是制造商给出的2年有效期)。然而,在为期6个月的稳定性研究中分析的样品显示,在4°C或25°C下储存CH溶液在药物含量、MIC或无菌性方面没有任何统计学差异。3个月的加速稳定性研究表明,只有在55°C下储存2个月后,药物才会开始降解,并且可以观察到统计学差异。结论:ch -眼药水在室温下保存6个月对抗生素的稳定性没有影响。
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引用次数: 3
Sexual functions of female patients with chronic liver disease from two centers in Nigeria 尼日利亚两个中心慢性肝病女性患者的性功能
Pub Date : 2018-07-01 DOI: 10.4103/LIUJ.LIUJ_24_18
O. Adekanle, S. olowookere, O. Ijarotimi, D. Ndububa, O. Ayodeji
Background: Chronic liver disease (CLD) is a disease with significant morbidity and mortality in Nigeria. This study assessed the sexual functions of women with chronic hepatitis B infection (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) designated as cases and normal women as controls. Methods: A prospective, comparative, case–control study of CHB, LC, HCC, and controls. Consenting cases and controls completed a self-administered Female Sexual Function Questionnaire (FSFI). Bio-data was obtained for all participants and cases were graded using the Child–Turcotte–Pugh scores (CTP). Data obtained were entered into SPSS version 20 and analyzed using descriptive and inferential statistics. Results: A total of 176 women completed the study, comprising 88 cases and 88 controls. Mean age (standard deviation) was 39.5 + 8.5 years and 40.5 + 8.2 years for cases and controls, respectively. Cases comprised CHB – 46, LC – 25, and HCC – 17, and their CTP classes were CTP A, 54; CTP B, 22; and CTP C, 12. The FSFI scores for CHB compared with controls were not statistically significant in all domains of the FSFI. The FSFI scores for LC and HCC in all domains were statistically significant compared with controls. Total mean FSFI scores for cases in CTP Class C showed sexual dysfunction, where 13.6% of CLD and 6.8% of all participants had sexual dysfunction and none among the controls. Conclusions: Females with advanced CLD had sexual dysfunction. Sexual concerns of females with CLD should be inquired for and treated.
背景:在尼日利亚,慢性肝病(CLD)是一种发病率和死亡率很高的疾病。本研究评估了慢性乙型肝炎感染(CHB)、肝硬化(LC)和肝细胞癌(HCC)女性患者的性功能,并将其作为病例和正常女性作为对照。方法:对CHB、LC、HCC和对照组进行前瞻性、比较、病例对照研究。同意的病例和对照组完成了自我管理的女性性功能问卷(FSFI)。获得所有参与者的生物数据,并使用child - turcote - pugh评分(CTP)对病例进行评分。所得数据输入SPSS version 20,采用描述性统计和推理统计进行分析。结果:共有176名妇女完成了研究,其中88例为病例,88例为对照。病例和对照组的平均年龄(标准差)分别为39.5 + 8.5岁和40.5 + 8.2岁。病例包括CHB - 46、LC - 25和HCC - 17,其CTP分类为CTP A、54;CTP b, 22;CTP C为12。CHB的FSFI评分与对照组相比,在FSFI的所有领域均无统计学意义。与对照组相比,LC和HCC各领域的FSFI评分均有统计学意义。CTP C类病例的总平均FSFI评分显示性功能障碍,其中13.6%的CLD和6.8%的所有参与者有性功能障碍,而对照组中没有性功能障碍。结论:晚期CLD女性存在性功能障碍。女性CLD的性问题应询问和治疗。
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引用次数: 1
Is metabolic syndrome truly prevailing in nondiabetic Libyan women 代谢综合征真的在非糖尿病的利比亚妇女中普遍存在吗
Pub Date : 2018-07-01 DOI: 10.4103/liuj.liuj_39_18
M. Al-Mendalawi
{"title":"Is metabolic syndrome truly prevailing in nondiabetic Libyan women","authors":"M. Al-Mendalawi","doi":"10.4103/liuj.liuj_39_18","DOIUrl":"https://doi.org/10.4103/liuj.liuj_39_18","url":null,"abstract":"","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78004270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Libyan International Medical University Journal
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