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Antioxidant Activities and Phenolic Composition of Sarcococca saligna Leaves 沙棘叶的抗氧化活性和酚类成分
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-03-18 DOI: 10.2174/0115701786293349240229074809
Syed Mubashar Sabir, Shabnam Shahida, Alam Zeb, Syed Rizwan Abbas, Muhammad Usman Hameed, Abdallah Shanableh, Muhammad Imran Khan, Djamel Ghernaout, Ramzi Hadj Lajimi, Sarra Elgharbi, Malek Besbes, Noureddine Elboughdiri
: Sarcococca saligna (D. DON) Muel is a vital plant with several steroidal alkaloids and is effective against syphilis, liver diseases, gastrointestinal tract disease, infections, and inflammation. The present study aimed to investigate the in vitro antioxidant activities and phenolic profile of S. saligna. High-performance liquid chromatography (HPLC) analysis has shown the presence of twelve phenolics namely kaempferol-3-O-glucoside, proanthocyanidin B1, quercetin-3-malonylglucoside- 7-glucoside, kaempferol-3-O-sophorotioside, Isorhamnetin-3-O-glucoside-7-Orhamnoside, kaempferolhexoside, 4-O-Caffeoyl-5-O-p-coumaroylquinic acid, 3,4-Di-O-caffeoyl-5- O-feruloylquinic acid, 3,4-Di-O-feruloyl-5-O-caffeoylquinic acid, flavogalloyl-HHDP-gluconic acid (lagerstannin B), 3,4-di-O-caffeoylquinic acid and kaempferol-3-(caffeoyldiglucoside)-7-glucoside. The hot water extract showed the highest anti-lipid peroxidative activities. The IC50 value for 2,2- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was 71.5 ± 2.1 μg/mL. The extract could chelate the iron and possess reducing activities on phosphomolybenum assay. It is concluded that extracts of S. saligna are rich in antioxidants and contain essential phytochemicals. objective: The present study was aimed to investigate thein vitro antioxidant activities and phenolic profile of S. saligna. HPLC analysis has shown the presence of twelve phenolics namely kaempferol-3-O-glucoside, proanthocyanidin B1, quercetin-3-malonyl-glucoside-7-glucoside, kaempferol-3-O-sophorotioside,Isorhamnetin-3-O glucoside-7-O-rhamnoside,kaempferolhexoside, 4-O-Caffeoyl-5-O-p-coumaroylquinic acid, 3,4-Di-O-caffeoyl-5-O-feruloylquinic acid, 3,4-Di-O-feruloyl-5-O-caffeoylquinic acid, flavogalloyl-HHDP-gluconic acid (lagerstannin B), 3,4-di-O-caffeoylquinic acid and kaempferol-3-(caffeoyldiglucoside)-7-glucoside. method: The chemical used were 1,10-phenathroline, Thibarbituric acid, TRIS-HCl, amominium molybdate, Iron, sodium nitroprusside. HPLC standards were purchased from Sigma-Aldrich. All the reagents were of analytical grade. Double beam spectrophotometer was used for UV-VIS spectrophotometery. The HPLC system used was Agilent 1260 Infinity HPLC system which consists of quaternary pump, degasser, auto-sampler and diode array detector (DAD). conclusion: The results have shown that S. saligna antioxidant rich extract can be effectively utilized in food and pharmaceutical industries with additional income. However, more detailed understanding of utilization of extract against degenerative diseases is required. There is also need to find out the safety and bioavailability of the plant extract for its use as nutraceutical and as a plant products.
:Sarcocca saligna (D. DON) Muel 是一种重要的植物,含有多种甾体生物碱,对梅毒、肝病、胃肠道疾病、感染和炎症有效。本研究旨在调查 S. saligna 的体外抗氧化活性和酚类概况。高效液相色谱法(HPLC)分析表明,沙参中含有 12 种酚类物质,即山奈酚-3-O-葡萄糖苷、原花青素 B1、槲皮素-3-丙二酰葡萄糖苷-7-葡萄糖苷、山奈酚-3-O-槐糖苷、异鼠李素-3-O-葡萄糖苷-7-Orhamnoside、山奈酚己糖苷、4-O-咖啡酰-5-O-对香豆酰奎宁酸、3,4-二-O-咖啡酰-5-O-阿魏酰奎宁酸、3,4-二-O-阿魏酰-5-O-咖啡酰奎宁酸、黄烷酰-HHDP-葡萄糖酸(拉格斯塔宁 B)、3,4-二-O-咖啡酰奎宁酸和山奈酚-3-(咖啡酰二葡萄糖苷)-7-葡萄糖苷。热水提取物的抗脂质过氧化活性最高。2,2-二苯基-1-苦基肼(DPPH)自由基清除活性的 IC50 值为 71.5 ± 2.1 μg/mL。该提取物能螯合铁,在磷钼试验中具有还原活性。由此得出结论,S. saligna 的提取物含有丰富的抗氧化剂和重要的植物化学物质:本研究旨在调查 S. saligna 的体外抗氧化活性和酚类概况。高效液相色谱分析显示了 12 种酚类物质的存在,即山奈酚-3-O-葡萄糖苷、原花青素 B1、槲皮素-3-丙二酰基葡萄糖苷-7-葡萄糖苷、山奈酚-3-O-槐角苷、异鼠李素-3-O-葡萄糖苷-7-O-鼠李糖苷、山奈酚己糖苷、4-O-咖啡酰-5-O-对香豆酰奎宁酸、3,4-二-O-咖啡酰-5-O-阿魏酰奎宁酸、3,4-二-O-阿魏酰-5-O-咖啡酰奎宁酸、黄加洛尔-HHDP-葡萄糖酸(拉格斯塔宁 B)、3,4-二-O-咖啡酰奎宁酸和山奈酚-3-(咖啡酰二葡萄糖苷)-7-葡萄糖苷。方法:所用化学试剂为 1,10-酚酞、巴比妥酸、TRIS-HCl、钼酸铵、铁、硝普钠。高效液相色谱标准品购自 Sigma-Aldrich。所有试剂均为分析级。紫外-可见分光光度计采用双光束分光光度计。使用的高效液相色谱系统是 Agilent 1260 Infinity 高效液相色谱系统,该系统由四元泵、脱气机、自动进样器和二极管阵列检测器(DAD)组成:研究结果表明,沙参富含抗氧化剂的提取物可有效用于食品和制药行业,并带来额外收入。然而,还需要更详细地了解如何利用萃取物防治退行性疾病。此外,还需要找出植物提取物的安全性和生物利用度,以便将其用作营养保健品和植物产品。
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引用次数: 0
Polydopamine-Modified Magnetic Nanoparticles (Fe3O4@PDA) for the Copper-Catalyzed Ipso-Hydroxylation of Arylboronic Acids and Subsequent O-Benzylation in Aqueous Media 多多巴胺修饰的磁性纳米粒子(Fe3O4@PDA)用于铜催化的芳硼酸异羟基化及随后在水介质中的 O-苄基化反应
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-03-14 DOI: 10.2174/0115701786294756240305063556
Kwang-Beom Lee, Ueon Sang Shin, Seung-Hoi Kim
: A novel advancement has emerged in the realm of catalysis with the development of an innovative method for the ipso-hydroxylation of arylboronic acids. This approach harnessed the power of bio-compatible polydopamine-coated magnetite support (Fe3O4@PDA) in conjunction with a copper salt, forming a heterogeneous catalytic environment. The resulting catalytic system facilitated oxidative hydroxylation under mild aerobic conditions at room temperature in aqueous conditions. This environmentally friendly process allowed for the seamless conversion of diverse arylboronic acids featuring varying electron-withdrawing or electron-donating groups into the corresponding phenols, achieving remarkably high yields. Notably, the versatility of the catalytic system extended to a one-pot tandem O-benzylation of the resultant phenolic intermediates. The additional dimension of the process underscores its efficiency, offering a streamlined route to synthesizing benzyl phenyl ethers with a commendable level of success. The significance of the present catalytic methodology lies not only in its efficacy but also in its eco-friendly attributes, showcasing the potential for sustainable and efficient transformations in organic synthesis.
:催化领域取得了新的进展,开发出了一种创新的芳基硼酸异羟基化方法。这种方法利用了生物相容性聚多巴胺涂层磁铁矿支持物(Fe3O4@PDA)与铜盐的力量,形成了一种异相催化环境。由此产生的催化系统可在室温水溶液条件下的温和有氧条件下促进氧化羟化。这种环境友好型工艺可将具有不同电子吸收基团或电子捐赠基团的各种芳基硼酸无缝转化为相应的苯酚,并获得显著的高产率。值得注意的是,该催化系统的多功能性还延伸到了由此产生的酚类中间体的单锅串联 O-苄基化。该工艺的额外层面凸显了其效率,为合成苄基苯基醚提供了一条简化的途径,并取得了令人称道的成功。本催化方法的意义不仅在于其功效,还在于其生态友好的属性,展示了有机合成中可持续和高效转化的潜力。
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引用次数: 0
Effective Synthesis of N-Alkyl-3-(Indol-3-yl)Pyrazoles from Ag2CO3-Catalyzed Regioselective Aza-Michael Addition of 5-(Indol-3-yl)-1HPyrazoles 由 Ag2CO3 催化的 5-(吲哚-3-基)-1HP 吡唑的区域选择性 Aza-Michael 加成有效合成 N-烷基-3-(吲哚-3-基)吡唑
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-03-12 DOI: 10.2174/0115701786295074240305095904
Xue Zhang, Dashuang Luo, Xuemin Niu, Jian Mo, Haifeng Yu, Xiaobo Zhao
: In this study, the synthesis of N-alkyl-3-(indol-3-yl)pyrazoles was carried out from Ag2CO3 catalyzed regioselective aza-Michael addition of 5-(indol-3-yl)-1H-pyrazoles to a, bunsaturated carbonyl compounds. In the presence of 10 mol% of Ag2CO3, the reaction smoothly occurred in dichloroethane (DCE) at 120oC to preferentially afford a series of N-alkyl-3-(indol-3- yl)pyrazoles in high yields with good regioselectivity. It was found that 1-methyl-3-(3-methyl-1Hpyrazol- 5-yl)-2-phenyl-1H-indole, 1-benzyl-3-(3-methyl-1H-pyrazol-5-yl)-1H-indole, a, b-unsaturated ketone, and a, b-unsaturated amide exclusively gave 3-(pyrazol-3-yl)indoles in good yields. This reaction features high regioselectivity, mild reaction conditions, good substrate scope and yields, and a commercially available catalyst. Meanwhile, the reaction was also proven to be quite practical by the gram-scale synthesis of N-alkyl-3-(indol-3-yl)pyrazoles in excellent yields with good regioselectivity.
本研究以 Ag2CO3 催化 5-(吲哚-3-基)-1H-吡唑与 a、bnsaturated 羰基化合物的区域选择性偶氮-迈克尔加成反应为基础,合成了 N-烷基-3-(吲哚-3-基)吡唑。在 10 mol% 的 Ag2CO3 存在下,反应在二氯乙烷(DCE)中于 120oC 温度下顺利进行,优先得到一系列 N-烷基-3-(吲哚-3-基)吡唑,产率高且具有良好的区域选择性。研究发现,1-甲基-3-(3-甲基-1H-吡唑-5-基)-2-苯基-1H-吲哚、1-苄基-3-(3-甲基-1H-吡唑-5-基)-1H-吲哚、a,b-不饱和酮和 a,b-不饱和酰胺都能以良好的收率得到 3-(吡唑-3-基)吲哚。该反应具有高区域选择性、反应条件温和、底物范围广、产率高以及催化剂可在市场上买到等特点。同时,通过克级规模合成 N-烷基-3-(吲哚-3-基)吡唑,也证明了该反应的实用性。
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引用次数: 0
Identification and Synthesis of Oxidative-Degradation and Starting Materials-Attributed Impurities in Lisdexamfetamine Dimesylate 氧化降解和起始原料引起的二甲磺酸利司他敏杂质的鉴定与合成
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-03-05 DOI: 10.2174/0115701786284263240219080226
Suryabhan B. Chaugule, Pradip L. Gole, Siddhesh Haldankar, DVP Kishore, Nilesh L. Bonde, Sandeep A. Kotharkar
: Impurities are an integral part of drug substances, even though they have not been studied in the pharmacological evaluation of the Benefit-Risk (BR) profiles. Hence, understanding their origin and controlling them have prime importance during drug substance development. The structures of some of the impurities in lisdexamfetamine dimesylate, a central nervous system stimulant drug, have been confirmed based on literature and analytical data. The study has been undertaken to evaluate impurities arising from oxidative degradation and impurities due to material attributes. All the listed impurities have been identified, synthesized, and characterized by spectral tools. We have, herein, reported the synthesis of two oxidative degradant impurities, 2-hydroxylisdexamfetamine dimesylate and 4-hydroxylisdexafetamine dimesylate. In addition, chiral isomeric impurities of lisdexamfetamine dimesylate as (S,R), (R,S) and (R,R)-lisdexamfetamine dimesylate have also been reported. These impurities have been identified and synthesized, and a control strategy for mitigating risk in lisdexamfetamine dimesylate is provided.
:杂质是药物的一个组成部分,尽管在效益-风险(BR)药理学评估中尚未对其进行研究。因此,在药物开发过程中,了解杂质的来源并加以控制至关重要。根据文献和分析数据,已确认了中枢神经系统兴奋剂药物二美甲酸利司西他敏中一些杂质的结构。这项研究旨在评估氧化降解产生的杂质和材料属性导致的杂质。所有列出的杂质都已通过光谱工具进行了鉴定、合成和表征。我们在此报告了两种氧化降解杂质--2-羟基异地苯乙胺二甲酸酯和 4-羟基异地苯乙胺二甲酸酯的合成。此外,还报道了(S,R)、(R,S) 和 (R,R)-lisdexamfetamine dimesylate 手性异构体杂质。对这些杂质进行了鉴定和合成,并提供了降低二甲酸利司西他敏风险的控制策略。
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引用次数: 0
[EMIM] [OAc]: An Efficient Ionic Liquid Medium for the Synthesis of New 4-(furan/pyrrole/thiophene-2-yl)-3, 4-dihydro-1H-chromeno [4,3- d]pyrimidine-2,5-diones and Molecular Docking Studies [EMIM] [OAc]:合成新型 4-(呋喃/吡咯/噻吩-2-基)-3, 4-二氢-1H-苯并吡喃 [4,3- d]嘧啶-2,5-二酮的高效离子液体介质及分子对接研究
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-03-01 DOI: 10.2174/0115701786289993240215104621
Siva Prakash Pullagura, Arunkumar Thiriveedhi, Venkateswara Rao Battula, Raghunadh Akula, A. Sajeli Begum, Lakshmi Soukya P.S.
: An efficient synthesis of Chromeno[b]pyrimidine derivatives 4 has been achieved by treating 4-hydroxy-2H-chromen-2-one 1, furan-2-carbaldehyde / 1H-pyrrole-2-carbaldehyde/ thiophene-2- carbaldehyde 2, and urea/thiourea 3 at 65-70 °C for 90-120 min using 1-Ethyl-3-methylimidazolium acetate as ionic liquid and medium with good yields 86-90%. This synthetic method has numerous advantages, including high yields, a simple protocol, environmental friendliness, brief reaction times, and mild reaction conditions. Using a catalytically active ionic liquid as the medium eliminates the need for a catalyst and a solvent. In this study, the docking score of the synthesized compounds was found to be between -8 to -9 kcal/mol similar to the co-crystal. Additionally, the compounds maintained their amino acid interactions with Tyr 281 (coagulation protein; 6WV3) and Thr 179 (tubulin polymerization protein; 5LYJ.pdb).
:以 1-乙基-3-甲基咪唑鎓乙酸盐为离子液体和介质,在 65-70 °C 下处理 4-羟基-2H-色烯-2-酮 1、呋喃-2-甲醛/1H-吡咯-2-甲醛/噻吩-2-甲醛 2 和脲/硫脲 3 90-120 分钟,高效合成了色烯并[b]嘧啶衍生物 4,收率高达 86-90%。这种合成方法具有收率高、方案简单、环保、反应时间短、反应条件温和等诸多优点。使用具有催化活性的离子液体作为介质,无需催化剂和溶剂。本研究发现,合成化合物的对接得分介于 -8 至 -9 kcal/mol 之间,与共晶体相似。此外,这些化合物与 Tyr 281(凝血蛋白;6WV3)和 Thr 179(微管蛋白聚合蛋白;5LYJ.pdb)保持着氨基酸相互作用。
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引用次数: 0
Cholesterol-Based B-Ring 2H-Pyran: Synthesis and Reaction Mechanism by Using Density Functional Theoretical Study 基于胆固醇的 B 环 2H-Pyran:利用密度函数理论研究合成和反应机理
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-03-01 DOI: 10.2174/0115701786287116240222045947
Priyanka -, Himanshi Kumar, Kamlesh Sharma
: The steroidal B-ring 2H-pyran 2 is synthesized by reacting steroidal B-ring α,β- unsaturated ketone 1 and 2-cyano-N-methylacetamide by refluxing for 18 h in methanol in the presence of a catalyst, i.e., chitosan. The product is obtained with a yield of 67%. The structure of the final product 2 is confirmed by utilizing IR, Mass, 13C and 1H NMR spectra. The reaction mechanism of the steroidal pyran ring formation is explored in this paper. The reaction pathway is described by using FMO analysis and relative energies of starting material, intermediate, and transition states, calculated by using the theoretical method, i.e., DFT with B3LYP/6-31G(d). It is found that two intermediates are formed throughout the reaction, which undergo a respective transition state (TS1 and TS2). The energy barrier of each step of the reaction is also calculated. It is also concluded that the reaction is endothermic. The green synthetic method reported in this study would be very useful for the synthetic and medicinal chemists involved in the synthesis of biologically important pyran ring-containing heterocyclic compounds.
:在催化剂(即壳聚糖)存在下,将甾体 B 环 α、β- 不饱和酮 1 和 2-氰基-N-甲基乙酰胺在甲醇中回流 18 小时,合成甾体 B 环 2H-吡喃 2。产品的产率为 67%。利用红外光谱、质谱、13C 和 1H NMR 光谱证实了最终产物 2 的结构。本文探讨了固醇吡喃环形成的反应机理。利用 FMO 分析和理论方法(即 B3LYP/6-31G(d) DFT)计算的起始物质、中间体和过渡态的相对能量,对反应途径进行了描述。结果发现,在整个反应过程中会形成两个中间体,它们分别经历了一个过渡态(TS1 和 TS2)。还计算了反应每一步的能障。研究还得出结论,该反应是内热反应。本研究中报告的绿色合成方法对参与合成具有重要生物意义的含吡喃环杂环化合物的合成和药物化学家非常有用。
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引用次数: 0
Selective Hydrogenation Reaction: Utilizing a Microreactor for Continuous Flow Synthesis of Nickel Nanoparticles 选择性氢化反应:利用微反应器连续流合成镍纳米粒子
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-02-27 DOI: 10.2174/0115701786268828240119105533
Vivek Srivastava
Introduction:: In this investigation, we employed a continuous flow reactor to synthesize nickel (Ni) nanoparticles exhibiting uniform size distribution and excellent stability. Our focus centered on exploring the impact of reactant dilution and flow rate on the synthesis process. Result:: It was observed that the optimization of these parameters played a pivotal role in obtaining small-sized Ni nanoparticles. Specifically, we achieved successful synthesis using a solution of 0.00025 M NiCl2·6H2O and 0.002 M NaBH4, with a flow rate of 25 mL/h. The resulting Ni nanoparticles were effectively coated with the CTAB surfactant, as confirmed through thorough analysis using TEM and PSD techniques. Additionally, the interaction between the surfactant and nanoparticles was verified via FTIR analysis. We subjected them to high-pressure alkene hydrogenation to assess the catalytic activity of the synthesized Ni nanoparticles. Method:: Encouragingly, the Ni nanoparticles exhibited excellent performance, producing hydrogenated products with high yields. Moreover, we capitalized on Ni nanoparticles' catalytic effect for synthesizing two natural compounds, brittonin A and dehydrobrittonin A. Remarkably, both compounds were successfully isolated in quantifiable yields. This synthesis protocol boasted several advantages, including low catalyst loading, omission of additives, broad substrate scope, straightforward product separation, and the ability to recover the catalyst up to eight times. In summary, this study effectively showcased the potential of continuous flow reactor technology in synthesizing stable and uniformly distributed nanoparticles. Conclusion:: Additionally, it highlighted the effectiveness of Ni nanoparticles as catalysts in various chemical reactions. The findings from this study hold significant implications for developing more efficient and sustainable chemical synthesis protocols.
简介:.....:在这项研究中,我们采用了一种连续流反应器来合成镍(Ni)纳米粒子,这种粒子具有均匀的尺寸分布和出色的稳定性。我们的重点是探索反应物稀释和流速对合成过程的影响。结果::通过观察发现,这些参数的优化在获得小尺寸镍纳米粒子的过程中发挥了关键作用。具体来说,我们使用 0.00025 M NiCl2-6H2O 和 0.002 M NaBH4 的溶液,以 25 mL/h 的流速成功合成了镍纳米粒子。通过使用 TEM 和 PSD 技术进行全面分析,我们证实所制备的镍纳米粒子有效包覆了 CTAB 表面活性剂。此外,我们还通过傅立叶变换红外光谱分析验证了表面活性剂与纳米颗粒之间的相互作用。我们将其用于高压烯烃氢化,以评估合成的镍纳米粒子的催化活性。方法:令人鼓舞的是,镍纳米粒子表现出了优异的性能,能以高产率生成氢化产物。此外,我们还利用镍纳米颗粒的催化作用合成了两种天然化合物--布里托宁 A 和脱氢布里托宁 A。该合成方案具有多个优点,包括催化剂负载量低、无需添加剂、底物范围广、产物分离简单以及催化剂可回收八次。总之,这项研究有效地展示了连续流反应器技术在合成稳定、分布均匀的纳米颗粒方面的潜力。结论此外,该研究还强调了镍纳米粒子作为催化剂在各种化学反应中的有效性。本研究的发现对开发更高效、更可持续的化学合成方案具有重要意义。
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引用次数: 0
Apigenin Bioisosteres: Synthesis and Evaluation of their Antioxidant, Antimicrobial, and Anticancer Activities 芹菜素生物异构体:合成及其抗氧化、抗菌和抗癌活性评估
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-02-27 DOI: 10.2174/0115701786287193240215101054
Juhi Gupta, Kalyani Thombre, Krishna Gupta, Milind Umekar
: A novel series of Apigenin bioisosteres [1(4-chlorophenyl)-3-phenyl prop-2-ene-1-one] non-cyclic derivatives (4a-4c) and [7-hydroxy-2-phenyl-4H-chromen-4-one] cyclic derivatives (9a- 9d) were synthesized. The newly synthesized apigenin bioisosteres were confirmed using UV, IR, NMR, and mass spectroscopic methods. The antioxidant, antibacterial, and anti-cancer activities of all newly synthesized compounds were assessed using the DPPH free radical scavenging capacity, disc diffusion method, and in vitro MTT assay on the human breast cancer MCF-7 cell line. Almost all the synthesized apigenin bioisosteres had greater antioxidant and antimicrobial activity than standard Apigenin. Out of seven compounds (4a-4c and 9a-9d), five compounds were found to exhibit notable antiproliferative activity on the breast cancer cell line (MCF-7), whereas two compounds, 9c and 9d, did not show notable activity. Our analysis suggests that synthesized Apigenin bioisosteres function as prospective antioxidant, antimicrobial, and anticancer agents.
合成了一系列新型芹菜素生物异斯特化合物[1(4-氯苯基)-3-苯基丙-2-烯-1-酮]非环状衍生物(4a-4c)和[7-羟基-2-苯基-4H-色烯-4-酮]环状衍生物(9a-9d)。利用紫外、红外、核磁共振和质谱方法证实了新合成的芹菜素生物异构体。利用 DPPH 自由基清除能力、圆盘扩散法和体外 MTT 法对人乳腺癌 MCF-7 细胞系进行了抗氧化、抗菌和抗癌活性评估。与标准芹菜素相比,几乎所有合成的芹菜素生物异斯特化合物都具有更强的抗氧化和抗菌活性。在七个化合物(4a-4c 和 9a-9d)中,发现五个化合物对乳腺癌细胞株(MCF-7)具有显著的抗增殖活性,而两个化合物(9c 和 9d)则没有表现出显著的活性。我们的分析表明,合成的芹菜素生物异构体具有抗氧化、抗菌和抗癌功能。
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引用次数: 0
Fireballs-Like Explosive Peroxides Produced by the Brown-rot Fungus 褐腐真菌产生的火球状爆炸性过氧化物
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-02-27 DOI: 10.2174/0115701786267733240215043302
Gerson S. Paiva
: Fireballs are unusual and rare phenomena usually associated with thunderstorms, although sometimes they have been observed during earthquakes, volcano eruptions or in fair weather. There are still questions about their origination, features and interaction with the environment. In this work, a new model is shown to explain the formation of fireballs in fair weather from poplar cotton and peroxides produced by brown-rot fungi. Light emission is produced via thermal decomposition of 1,2- dioxetane phenylcoumarane or 1,2-dioxetane monolignol, from lignin inside the poplar fibers. The energy released during the explosive decaying of fireballs was calculated as being about 3 kilojoules for each gram. This value is the same order of magnitude as the estimated for the explosive fireballs decaying.
:火球是一种不寻常的罕见现象,通常与雷暴有关,但有时也会在地震、火山爆发或天气晴朗时被观测到。人们对火球的起源、特征以及与环境的相互作用仍有疑问。在这项研究中,一个新的模型解释了在晴朗天气中杨树棉花和褐腐真菌产生的过氧化物形成的火球。光辐射是通过杨木纤维内部木质素中的 1,2- 二氧杂环丁烷苯基香豆素或 1,2- 二氧杂环丁烷单木质素的热分解产生的。据计算,每克火球在爆炸衰变过程中释放的能量约为 3 千焦。这一数值与爆炸性火球衰变的估计值处于同一数量级。
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引用次数: 0
Recent Advances in Biginelli Reaction using Nanoparticles, Zeolites and Metal Compounds as Catalyst: A Concise Review 使用纳米颗粒、沸石和金属化合物作为催化剂的比吉内利反应的最新进展:简明综述
IF 0.8 4区 化学 Q4 Chemistry Pub Date : 2024-02-22 DOI: 10.2174/0115701786291084240206113913
Bhaktiben R Bhatt, Dr. Bharat C. Dixit, Dr. Vipul B. Kataria, Dr. Ritu B. Dixit, Shaffiq Saiyad
:: The year 1891 is considered as a historic year in chemical science due to the introduction of novel heterocyclic compounds by P. Biginelli. The classical Biginelli reaction offers 3,4- dihydropyrimidin-2(1H)-ones/thiones in occupancy of acids like Broansted and Lewis. Multifaceted Dihydropyrimidones (DHPMs) have gained much importance due to their high biological activities. Several nanoparticles, zeolites and metal compounds are disclosed to improve the yield of this product. This review subsumes the evolution and effectiveness of catalysts. It summarises the main synthetic routes which are known to obtain DHPMs using these catalysts. The majority of these catalysts delivered satisfying catalytic activity which was more than 80% in the vicinity of producing Biginelli adducts. We hope this review article will be useful to researchers in terms of obtaining higher yields in a shorter time using easily available and reusable catalysts.
::由于 P. Biginelli 推出了新型杂环化合物,1891 年被认为是化学科学史上具有历史意义的一年。经典的 Biginelli 反应提供了 3,4-二氢嘧啶-2(1H)-酮/硫酮,与 Broansted 和 Lewis 等酸发生反应。多元二氢嘧啶酮(DHPMs)因其较高的生物活性而备受重视。为提高该产品的产量,已公开了几种纳米颗粒、沸石和金属化合物。本综述介绍了催化剂的演变和有效性。它总结了目前已知的使用这些催化剂获得 DHPM 的主要合成路线。这些催化剂大多具有令人满意的催化活性,在生产 Biginelli 加合物方面的催化活性超过 80%。我们希望这篇综述文章能对研究人员有所帮助,使他们能使用易于获得且可重复使用的催化剂,在更短的时间内获得更高的产率。
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引用次数: 0
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Letters in Organic Chemistry
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