Whether firms can survive a major crisis is an important question for both researchers and practitioners. Ambidexterity is frequently proposed as a sound strategy to achieve best performance when firms exist in turbulent environments; however, it is unclear whether this effect is sustained in a crisis, especially an internal one. Applying configuration and dynamic capability theories, this study extends the literature and examines this question by investigating how exploitation, exploration, and ambidexterity affect firms’ survival rates after major crises. This study is based on collected annual reports of and financial data on 367 firms that encountered a major crisis over a 21-year period (2000–2020) to provide empirical evidence. We employed a decision-tree analysis method based on text mining. The results show that during a crisis, firms adopting an exploitation strategy have a higher likelihood of survival than those adopting exploration and ambidexterity. Meanwhile, in the high-tech industry, adopting an ambidexterity or an exploitation strategy is better than adopting an exploration strategy. Theoretical and practical implications are provided.