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2014 International Symposium on Micro-NanoMechatronics and Human Science (MHS)最新文献

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Thin active fixture to hold finger for easy attachment and comfort of exoskeleton 薄的主动夹具,以保持手指易于连接和舒适的外骨骼
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006092
Y. Hasegawa, Takeshi Suzuki
This paper proposes a thin active fixture that holds a human body to attach and detach an exoskeleton with less effort and time. This fixture does not become wearer's burden due to a light weight and interfere with finger motions due to a thin shape. A required time to attach/detach a grasping support exoskeleton to/from fingers and a wrist by our fixtures is shorter than one of Velcro.
本文提出了一种薄的有源夹具,它可以使人体更省力、更省时地附着和分离外骨骼。这种夹具不会因为重量轻而成为佩戴者的负担,也不会因为形状薄而干扰手指的运动。通过我们的夹具将抓握支撑外骨骼从手指和手腕上附着/分离所需的时间比魔术贴短。
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引用次数: 2
High performance cell membrane perforation system for cell suspensions 用于细胞悬浮液的高性能细胞膜穿孔系统
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006103
Takaaki Mori, Yukihiro Akiyama, Shogo Unuma, T. Saito
We found a unique cell membrane perforation method which is applying photochemical oxidation on a limited area of the cell membrane, with high survival rate. We recently developed an nano needle array cell membrane perforator which is containing photosensitizer for mass cell processing and a robotic processing system. However, There were problems that the perforating processing efficiency for floating cells was low and that the sequential processing could not be performed in the method. In order to apply the perforating method to a cell therapy, we should devise the system components which can perform sequential perforation processing. In this report, we developed core components of the process for cell suspensions. The components are membrane filter and its supporting block, to support the cells during the perforation process and to pass through the medium. We evaluated the system with a fluorochrome introduction to the cells. With the system, we could inject membrane impermeable fluorescent dye AlexaFluor594 to the floating rat PC12 cells. This reveals that our sequential cell processing concept is adequate. By combining some flow control system for feeding the cell suspension, the system will be developed as an automatic bed-side cell processing system for various cell therapies.
我们发现了一种独特的细胞膜穿孔方法,即在有限的细胞膜面积上进行光化学氧化,具有很高的存活率。我们最近开发了一种含有光敏剂的纳米针阵列细胞膜穿孔器,用于大规模细胞加工和机器人加工系统。但是,该方法存在着对浮胞穿孔处理效率低、不能进行顺序处理等问题。为了将穿孔方法应用于细胞治疗,我们应该设计能够进行连续穿孔处理的系统组件。在本报告中,我们开发了细胞悬浮液工艺的核心组件。所述组件为膜过滤器及其支撑块,在穿孔过程中支撑细胞并通过介质。我们用荧光染料导入细胞来评估该系统。利用该系统,我们可以将不透膜荧光染料AlexaFluor594注射到漂浮大鼠PC12细胞中。这表明我们的顺序单元处理概念是足够的。通过结合一些流动控制系统来喂入细胞悬浮液,该系统将发展成为一种自动床边细胞处理系统,用于各种细胞治疗。
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引用次数: 0
Secretion of different altered laminin isoforms results in three-dimensional morphological changes in cells cultured on Matrigel 不同的层粘连蛋白同种异构体的分泌导致在基质上培养的细胞的三维形态变化
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006160
M. Imai, Takeomi Mizutani, K. Kawabata, H. Haga
Epithelial cells are known to form structures, such as cysts and tubes, with three-dimensional (3-D) morphologies. During formation of the morphologies of these structures, apico-basal polarity is regulated by secretion of laminins and integrins. In this study, we observed epithelial cells with mushroom-like 3-D morphologies; many of these cells had tail structures, where endogenous laminin-α3, laminin-β1, and integrin-β1 were found to be accumulated. Interestingly, time-lapse observation of the cells showed rotational movement around the tail. We also observed the process of change from the single-cell morphology to the mushroom-like morphology. Additionally, we observed that single cells showed an elongated protrusion as a predecessor of the tail structure. In addition to laminin-α3, laminin-β1, and integrin-β1, laminin-β3 was also found to be localized in the protrusion. These results indicate that the apico-basal polarization and regulation of laminin secretion are crucial for the formation of the mushroom-like structure and for the rotational movement of Madin-Darby canine kidney (MDCK) cells cultured on Matrigel.
上皮细胞形成结构,如囊肿和管,具有三维(3-D)形态。在这些结构形态的形成过程中,顶基极性受层粘连蛋白和整合素分泌的调节。在这项研究中,我们观察到上皮细胞具有蘑菇样的三维形态;其中许多细胞具有尾部结构,内源性层粘连蛋白-α3、层粘连蛋白-β1和整合素-β1在尾部积聚。有趣的是,对这些细胞的延时观察显示它们在尾巴周围旋转。我们还观察了从单细胞形态到蘑菇状形态的变化过程。此外,我们观察到单细胞表现出细长的突出,作为尾部结构的前身。除了层粘连蛋白-α3、层粘连蛋白-β1和整合素-β1外,层粘连蛋白-β3也被发现存在于突起中。这些结果表明,在基质上培养的Madin-Darby犬肾(MDCK)细胞的蘑菇状结构的形成和旋转运动中,顶基极化和层粘连蛋白分泌调控是至关重要的。
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引用次数: 3
Wearable assistive device for lower limbs of caregiver on transferring support 可穿戴辅助装置,用于照顾者的下肢转移支持
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006126
Y. Hasegawa, Takashi Hoshino
This paper introduces a wearable assistive device for lower limbs of a caregiver who helps an elderly or a physically challenged person transferring among a bed, a wheelchair. This wearable assistive device is not environment-dependent such as a transferring lift or slide board. The assistive device sustains the caregiver's weight at his/her hip by landing a floor with a wheel during transferring assistance. This paper proposes a unique mechanism to change the landing point according to the task progress. The position of the landing point is mechanically controlled to follow center of gravity of the caregiver so that he/she could move right and left with less effort while he/she is unweighted. The mechanism also prevents a caregiver's falling backward while bracing the caregiver's hip part at arbitrary height. These functions are confirmed through experiments by measuring ground reaction forces and myoelectric potential of the caregiver.
本文介绍了一种可穿戴辅助装置,用于帮助老年人或残疾人在床上、轮椅上转移的护理人员的下肢。这种可穿戴的辅助设备不依赖于环境,如转移升降机或滑板。辅助装置通过在转移辅助过程中用轮子着陆地板来维持护理者在臀部的体重。本文提出了一种独特的根据任务进度改变着陆点的机制。着陆点的位置是机械控制的,以跟随护理者的重心,这样他/她就可以在他/她没有重量的情况下更轻松地左右移动。该装置还可以防止看护者向后摔倒,同时在任意高度支撑看护者的臀部部分。这些功能是通过测量护理者的地面反作用力和肌电位的实验来证实的。
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引用次数: 0
A computer simulation of reconstitute systems of motor proteins revealed biophysical phenomena relevant to biomedical engineering 运动蛋白重组系统的计算机模拟揭示了与生物医学工程相关的生物物理现象
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006153
T. Nitta, Yuki Ishigure
We present a simulation study of gliding assays of cytoskeletal filaments and their associated motor proteins. The gliding assays serve as a basis of applications of motor proteins for nanotechnology. For example, cargo-loading cytoskeletal filaments propelled by the associated motor proteins, which is so-called molecular shuttles (MSs), can be alternative to conventional transport on Lab-on-a-Chip. During the developments, researchers have encountered biophysical phenomena which cannot be easily elucidated, such as detailed mechanisms of guiding of MSs by microfabricated guiding tracks. Elucidating such phenomena is important for the developments of microscale biomedical devices. However, elucidation of the phenomena has been hampered by lack of detailed information. Such information is difficult to obtain through experiments. Here, using a computer simulation, we revealed biophysical phenomena during MS propulsions and guiding by microfabricated tracks.
我们提出了细胞骨架细丝及其相关运动蛋白的滑行实验模拟研究。滑行实验为纳米技术中运动蛋白的应用奠定了基础。例如,由相关运动蛋白推动的装载货物的细胞骨架细丝,即所谓的分子穿梭(MSs),可以替代芯片实验室上的传统运输。在发展过程中,研究人员遇到了一些难以解释的生物物理现象,如微导径引导MSs的详细机制。阐明这些现象对微型生物医学装置的发展具有重要意义。然而,由于缺乏详细的资料,对这一现象的阐明一直受到阻碍。这样的信息很难通过实验获得。在这里,我们使用计算机模拟,揭示了生物物理现象在MS推进和微加工轨迹引导。
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引用次数: 0
One double-stranded DNA probes as classifier of multi targeting strand 一个双链DNA探针作为多靶向链的分类器
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006166
A. Wibowo, K. Sekiyama
In this paper, we investigate an alternative double-stranded probe (dsProbe) system as detection platform that employs a similarity-based classifiers in DNA strand displacement reactions. We formulate label propagation based on DNA toehold domain as classifier, where a node propagates to neighboring nodes according to their proximity. We observe mismatch attributes of DNA strand sequences to recognize the effect of this model. The attributes are position, length and location number of mismatches. We carry out simulation using Nupack software and also experimental investigation..
在本文中,我们研究了一种替代双链探针(dsProbe)系统作为检测平台,该系统在DNA链位移反应中采用基于相似性的分类器。我们将基于DNA支点域的标签传播作为分类器,其中一个节点根据邻近节点的接近度传播到相邻节点。我们通过观察DNA链序列的错配属性来识别该模型的效果。属性是不匹配的位置、长度和位置数。利用Nupack软件进行了仿真,并进行了实验研究。
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引用次数: 0
Muscle biopsy system for extracting fibrous muscular tissue 用于提取纤维性肌肉组织的肌肉活检系统
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006058
A. Ushida, M. Nokata
A needle biopsy is a kind of the inspection to extract the muscles under the skin with a needle, the inspection method accelerated the research on muscle characteristic and a sick of muscle. Current needle can extract only the muscular tissue of a limited structure. Based on the above background, we work in research and development of novel needle biopsy system in order to extract muscle tissue with form of fiber. The system consists of an ultrasonic device, an angular adjustment implement, and a needle. The needle has curved shape so penetrates from skin surface perpendicularly and takes route parallel to bone in muscle tissue. When the needle is inserting in muscle, pressure are given for muscle tissue. And then reaction force was given to the tip of needle. We designed prototype of the needle's tip using reaction force to close. We report in this paper developing needle biopsy system and designing tip of needle.
针刺活检是一种用针刺提取皮肤下肌肉的检查方法,这种检查方法加速了对肌肉特征和肌肉病变的研究。目前的针只能提取有限结构的肌肉组织。基于以上背景,我们研究开发了一种新型的以纤维形式提取肌肉组织的针活检系统。该系统由超声波装置、角度调节器和针组成。针呈弯曲形状,从皮肤表面垂直穿入,并沿肌肉组织中与骨平行的路线穿入。当针插入肌肉时,肌肉组织受到压力。然后对针尖施加反作用力。我们设计了利用反作用力闭合针尖的原型。本文报道了针活检系统的研制和针尖的设计。
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引用次数: 1
Development of remote controllable visiting robot considering local situation 考虑局部情况的遥控探访机器人的研制
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006142
Shota Mitsumura, Yoshinobu Akimoto, E. Sato-Shimokawara, Toru Yamaguchi
Recently, various wheelchair robots are developed for improvement of usability of wheelchair. There are some types in users of wheelchair. We focused on users of wheelchair who live in the area far from their family or care giver. Because of depopulation and aging in rural area, it is expected that the number of such users of wheelchair increases. It is please them to go out and talk with their family or care giver. However, the family or the care giver can't easily to go to see him or her because it takes a lot of time and cost to go. And then we decided to develop a remote controllable wheelchair robot with the function of telepresence. On the other hand, the remote control is too risky for a local user of wheelchair robot. A wheelchair robot must be driven safely by a remote user. The purpose of this study is to improve safety of driving of the wheelchair robot by a remote user. We supposed that it is able to relieve the fear of local user and a remote user by improving a function of emergency stop. We conducted experiment to survey the size of comfortable space of a user on wheelchair robot.
近年来,为了提高轮椅的可用性,开发了各种轮椅机器人。轮椅使用者有几种类型。我们关注的是那些住在远离家人或照顾者的地区的轮椅使用者。由于农村地区人口减少和老龄化,预计这类轮椅使用者的数量将会增加。请他们出去与家人或照顾者交谈。然而,家人或照顾者不能轻易地去看他或她,因为去需要很多时间和费用。然后我们决定开发一个具有远程呈现功能的遥控轮椅机器人。另一方面,远程控制对于轮椅机器人的本地用户来说风险太大。轮椅机器人必须由远程用户安全驾驶。本研究的目的在于提高轮椅机器人的远程驾驶安全性。我们认为通过改进紧急停机功能,可以缓解本地用户和远程用户的恐惧心理。我们对轮椅机器人使用者的舒适空间大小进行了实验研究。
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引用次数: 1
Shape optimization of neck myoelectric signal control-type speaking valve 颈部肌电信号控制型说话阀的形状优化
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006108
Katsutoshi Oe, Kohei Sakurai
A speaking valve is one of the speech assistance devices, and it is used for speech cannula and tracheal opening retainer user. Conventional speaking valves have one-way valve mechanism, they open when the user breathes in, and they close when user breathes out and produces a voice. This type is very simple and tough, but it has a problem about closeness of the user. This problem is caused by its mechanism what can not be controlled by user's will. Therefore, we proposed a myoelectric control-type speaking valve. This valve can be controlled by the myoelectric signal of sternohyoid muscle. From our previous results, it was clarified that this valve had better performance about easy-to-breath. But, the previous valve was too big and heavy to carry. In this report, we describe the development of compact myoelectric control-type speaking valve system. The new-type speaking valve is enough small to attach the human body, and its opening is larger than that of conventional speaking valve. Furthermore, the shape of flow channel is optimized by FEM analysis. According to the result of this analysis, this valve gets the low flow resistance channel.
语音阀是语音辅助装置之一,用于语音插管和气管开口固位器使用者。传统的说话阀为单向阀机构,当用户吸气时开启,当用户呼出并发出声音时关闭。这种类型非常简单和坚固,但它有一个关于用户亲密度的问题。造成这一问题的原因是其机制不受用户意志的控制。因此,我们提出了一种肌电控制型说话阀。这个瓣膜可以通过胸骨舌骨肌的肌电信号来控制。从我们之前的研究结果来看,该阀在易呼吸方面具有更好的性能。但是,以前的阀门太大太重,无法携带。在本报告中,我们描述了紧凑型肌电控制型说话阀系统的发展。新型说话阀体积小,可以附着在人体上,其开度也比传统的说话阀大。在此基础上,通过有限元分析对流道形状进行了优化。根据分析结果,该阀得到了低流阻通道。
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引用次数: 2
A study on tactile display for haptic sensing system with sensory feedback for laparoscopic surgery 基于感觉反馈的腹腔镜手术触觉传感系统的触觉显示研究
Pub Date : 2014-11-01 DOI: 10.1109/MHS.2014.7006169
Yoshihiro Tanaka, Shuji Aragaki, T. Fukuda, Michitaka Fujiwara, A. Sano
We have developed a haptic sensing system including human's haptic bidirectionality for tumor detection on the stomach wall in the laparoscopic surgery. The system has a tactile sensor and a tactile display. A surgeon can feel output from the tactile sensor mounted on forceps by the tactile display. In this paper, a tactile display for the haptic sensing system is investigated. We developed two types of wearable tactile displays that were mounted on the arm. An evaluation test showed that the tactile displays might be available to detect the lump in the haptic sensing system.
我们开发了一种包括人的触觉双向性的用于腹腔镜手术中胃壁肿瘤检测的触觉传感系统。该系统具有触觉传感器和触觉显示器。外科医生可以通过触觉显示器感受到安装在钳上的触觉传感器的输出。本文研究了一种用于触觉传感系统的触觉显示器。我们开发了两种类型的可穿戴触觉显示器,安装在手臂上。评估试验表明,触觉显示器可用于触觉传感系统中肿块的检测。
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引用次数: 3
期刊
2014 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
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