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Neurite Orientation Dispersion and Density Imaging (NODDI) reveals white matter microstructural changes in Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) patients with cognitive impairment 神经元定向弥散和密度成像(NODDI)揭示了伴有认知障碍的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的白质微结构变化
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-15 DOI: 10.1016/j.mri.2024.110234
Ke Ning , Dechao Fan , Yuzhu Liu , Yubing Sun , Yajie Liu , Yongzhong Lin

Purpose

This study aimed to assess changes in white matter microstructure among patients undergoing obstructive sleep apnea hypopnea syndrome (OSAHS) complicated by cognitive impairment through neurite orientation dispersion and density imaging (NODDI), and evaluate the relationship to cognitive impairment as well as the diagnostic performance in early intervention.

Methods

Totally 23 OSAHS patients, 43 OSAHS patients complicated by cognitive impairment, and 15 healthy controls were enrolled in OSA, OSACI and HC groups of this work. NODDI toolbox and FMRIB's Software Library (FSL) were used to calculate neurite density index (NDI), Fractional anisotropy (FA), volume fraction of isotropic water molecules (Viso), and orientation dispersion index (ODI). Tract-based spatial statistics (TBSS) were carried out to examine the above metrics with one-way ANOVA. This study explored the correlations of the above metrics with mini-mental state examination (MMSE), and montreal cognitive assessment (MoCA) scores. Furthermore, receiver operating characteristic (ROC) curves were plotted. Meanwhile, area under curve (AUC) values were calculated to evaluate the diagnostic performance of the above metrics.

Results

NDI, ODI, Viso, and FA were significantly different among different brain white matter regions, among which, difference in NDI showed the greatest statistical significance. In comparison with HC group, OSA group had reduced NDI and ODI, whereas elevated Viso levels. Conversely, compared to the OSA group, the OSACI group displayed a slight increase in NDI and ODI values, which remained lower than HC group, viso values continued to rise. Post-hoc analysis highlighted significant differences in these metrics, except for FA, which showed no notable changes or correlations with neuropsychological tests. ROC analysis confirmed the diagnostic efficacy of NDI, ODI, and Viso with AUCs of 0.6908, 0.6626, and 0.6363, respectively, whereas FA's AUC of 0.5042, indicating insufficient diagnostic efficacy.

Conclusions

This study confirmed that NODDI effectively reveals microstructural changes in white matter of OSAHS patients with cognitive impairment, providing neuroimaging evidence for early clinical diagnosis and intervention.

目的 本研究旨在通过神经元定向弥散和密度成像(NODDI)评估阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并发认知障碍患者的白质微结构变化,并评估其与认知障碍的关系以及早期干预的诊断性能。方法 本研究共招募了23名OSAHS患者、43名OSAHS并发认知障碍患者和15名健康对照者,分为OSA组、OSACI组和HC组。使用 NODDI 工具箱和 FMRIB 软件库(FSL)计算神经元密度指数(NDI)、分数各向异性(FA)、各向同性水分子体积分数(Viso)和方向分散指数(ODI)。通过单因素方差分析,对上述指标进行了分段空间统计(TBSS)。本研究探讨了上述指标与迷你精神状态检查(MMSE)和蒙特利尔认知评估(MoCA)评分的相关性。此外,还绘制了接收者操作特征曲线(ROC)。结果NDI、ODI、Viso和FA在不同脑白质区域之间存在显著差异,其中NDI的差异具有最大的统计学意义。与 HC 组相比,OSA 组的 NDI 和 ODI 降低,而 Viso 水平升高。相反,与 OSA 组相比,OSACI 组的 NDI 和 ODI 值略有上升,但仍低于 HC 组,而 Viso 值则继续上升。事后分析强调了这些指标的显著差异,但 FA 除外,没有显示出明显的变化或与神经心理测试的相关性。ROC分析证实了NDI、ODI和Viso的诊断效力,其AUC分别为0.6908、0.6626和0.6363,而FA的AUC为0.5042,表明诊断效力不足。
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引用次数: 0
Automatic generation of diffusion tensor imaging for the lumbar nerve using convolutional neural networks 利用卷积神经网络自动生成腰椎神经弥散张量成像
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-13 DOI: 10.1016/j.mri.2024.110237
Rira Masumoto , Yawara Eguchi , Hidenari Takeuchi , Kazuhide Inage , Miyako Narita , Yasuhiro Shiga , Masahiro Inoue , Noriyasu Toshi , Soichiro Tokeshi , Kohei Okuyama , Shuhei Ohyama , Noritaka Suzuki , Satoshi Maki , Takeo Furuya , Seiji Ohtori , Sumihisa Orita

【Purpose】

Diffusion Tensor Imaging (DTI) with tractography is useful for the functional diagnosis of degenerative lumbar disorders. However, it is not widely used in clinical settings due to time and health care provider costs, as it is performed manually on hospital workstations. The purpose of this study is to construct a system that extracts the lumbar nerve and generates tractography automatically using deep learning semantic segmentation.

【Methods】

We acquired 839 axial diffusion weighted images (DWI) from the DTI data of 90 patients with degenerative lumbar disorders, and segmented the lumbar nerve roots using U-Net, a semantic segmentation model. Using five architectural models, the accuracy of the lumbar nerve root segmentation was evaluated using a Dice coefficient. We also created automatic scripts from three commercially available software tools, including MRICronGL for medical image viewing, Diffusion Toolkit for reconstruction of the DWI data, and Trackvis for the creation of the tractography, and compared the time required to create the tractography, and evaluated the quality of the automated tractography was evaluated.

【Results】

Among the five models, the architectural model Resnet34 performed the best with a Dice = 0.780. The creation time for the automatic lumbar nerve tractography was 191 s, which was significantly shorter by 235 s than the manual time of 426 s (p < 0.05). Furthermore, the agreement between manual and automated tractography was 3.67 ± 1.53 (satisfactory).

【Conclusions】

Using deep learning semantic segmentation, we were able to construct a system that automatically extracted the lumbar nerve and generated lumbar nerve tractography. This technology makes it possible to analyze lumbar nerve DTI and create tractography automatically, and is expected to advance the clinical applications of DTI for the assessment of the lumbar nerve.

目的】带有束流成像的弥散张量成像(DTI)可用于腰椎退行性疾病的功能诊断。然而,由于需要在医院工作站上手动操作,因此受时间和医疗服务提供商成本的影响,该技术在临床上并未得到广泛应用。本研究的目的是构建一个系统,利用深度学习语义分割技术自动提取腰椎神经并生成牵引图。【方法】我们从90名腰椎退行性疾病患者的DTI数据中获取了839张轴向弥散加权图像(DWI),并利用语义分割模型U-Net分割了腰椎神经根。使用五种结构模型,用 Dice 系数评估了腰神经根分割的准确性。我们还利用三种市售软件工具创建了自动脚本,包括用于医学图像浏览的 MRICronGL、用于重建 DWI 数据的 Diffusion Toolkit 和用于创建牵引图的 Trackvis,并比较了创建牵引图所需的时间,评估了自动牵引图的质量。自动腰椎神经束成像的创建时间为 191 秒,比手动的 426 秒显著缩短了 235 秒(p <0.05)。此外,人工和自动腰椎神经束图的一致性为 3.67 ± 1.53(满意)。【结论】利用深度学习语义分割技术,我们能够构建一个自动提取腰椎神经并生成腰椎神经束图的系统。这项技术使分析腰椎神经 DTI 并自动生成牵引图成为可能,有望推动 DTI 在腰椎神经评估方面的临床应用。
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引用次数: 0
Prospective head motion correction at 3 Tesla with wireless NMR markers and ultrashort echo navigators 利用无线核磁共振标记和超短回波导航仪在 3 特斯拉条件下进行前瞻性头部运动校正。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-12 DOI: 10.1016/j.mri.2024.110238
Saikat Sengupta , Antonio Glenn , Baxter P. Rogers

Purpose

Prospective motion correction (PMC) with inductively-coupled wireless NMR markers has been shown to be an effective plug-and-play method for dealing with head motion at 7 Tesla [29,30]. However, technical challenges such as one-to-one identification of three wireless markers, generation of hyper-intense marker artifacts and low marker peak SNR in the navigators has limited the adoption of this technique. The goal of this work is to introduce solutions to overcome these issues and extend this technique to PMC for brain imaging at 3 Tesla.

Methods

PMC with 6 degrees of freedom (DOF) was implemented using a novel ∼8 ms, ultrashort echo time (UTE) navigator in concert with optimally chosen MnCl2 marker samples to minimize marker artifacts. Distinct head coil sensitivities were leveraged to enable identification and tracking of individual markers and a variable flip angle (VFA) scheme and real time filtering were used to boost marker SNR. PMC was performed in 3D T1 weighted brain imaging at 3 Tesla with voluntary head motions in adult volunteers.

Results

PMC with wireless markers improved image quality in 3D T1 weighted images in all subjects compared to non-motion corrected images for similar motions with no noticeable marker artifacts. Precision of motion tracking was found to be in the range of 0.01–0.06 mm/degrees. Navigator execution had minimal impact on sequence duration.

Conclusions

Wireless NMR markers provide an accurate, calibration-free and economical option for 6 DOF PMC in brain imaging across field strengths. Challenges in this technique can be addressed by combining navigator design, sample selection and real time data processing strategies.
目的:使用电感耦合无线核磁共振标记物进行前瞻性运动校正(PMC)已被证明是在 7 特斯拉条件下处理头部运动的一种有效的即插即用方法[29,30]。然而,技术上的挑战,如三个无线标记的一对一识别、高强度标记伪影的产生以及导航仪中标记峰值 SNR 的降低,限制了这一技术的应用。这项工作的目标是介绍克服这些问题的解决方案,并将该技术扩展到 3 特斯拉下的脑成像 PMC:方法:使用新颖的 ∼8 ms 超短回波时间 (UTE) 导航仪,配合优化选择的氯化锰标记样本,实现了具有 6 个自由度 (DOF) 的 PMC,以最大限度地减少标记伪影。利用不同的头部线圈灵敏度来识别和跟踪单个标记物,并采用可变翻转角(VFA)方案和实时滤波来提高标记物信噪比。在成年志愿者自愿头部运动的情况下,在 3 特斯拉的三维 T1 加权脑成像中进行了 PMC:结果:在所有受试者的三维 T1 加权成像中,与类似运动的非运动校正图像相比,使用无线标记的 PMC 提高了图像质量,而且没有明显的标记伪影。运动追踪的精确度在 0.01-0.06 毫米/度之间。导航仪的执行对序列持续时间的影响极小:无线 NMR 标记为不同场强的脑成像中的 6 DOF PMC 提供了准确、无需校准且经济的选择。这项技术所面临的挑战可通过结合导航仪设计、样本选择和实时数据处理策略来解决。
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引用次数: 0
POSE: POSition Encoding for accelerated quantitative MRI POSE:用于加速定量磁共振成像的位置编码。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-12 DOI: 10.1016/j.mri.2024.110239
Albert Jang , Fang Liu
Quantitative MRI utilizes multiple acquisitions with varying sequence parameters to sufficiently characterize a biophysical model of interest, resulting in undesirable scan times. Here we propose, validate and demonstrate a new general strategy for accelerating MRI using subvoxel shifting as a source of encoding called POSition Encoding (POSE). The POSE framework applies unique subvoxel shifts along the acquisition parameter dimension, thereby creating an extra source of encoding. Combining with a biophysical signal model of interest, accelerated and enhanced resolution maps of biophysical parameters are obtained. This has been validated and demonstrated through numerical Bloch equation simulations, phantom experiments and in vivo experiments using the variable flip angle signal model in 3D acquisitions as an application example. Monte Carlo simulations were performed using in vivo data to investigate our method's noise performance. POSE quantification results from numerical Bloch equation simulations of both a numerical phantom and realistic digital brain phantom concur well with the reference method, validating our method both theoretically and for realistic situations. NIST phantom experiment results show excellent overall agreement with the reference method, confirming our method's applicability for a wide range of T1 values. In vivo results not only exhibit good agreement with the reference method, but also show g-factors that significantly outperforms conventional parallel imaging methods with identical acceleration. Furthermore, our results show that POSE can be combined with parallel imaging to further accelerate while maintaining superior noise performance over parallel imaging that uses lower acceleration factors.
定量核磁共振成像利用不同序列参数的多次采集来充分表征感兴趣的生物物理模型,从而导致不理想的扫描时间。在这里,我们提出、验证并演示了一种新的通用策略,即 POSition Encoding(POSE),利用子体素移动作为编码源来加速磁共振成像。POSE 框架沿采集参数维度应用独特的子体素移动,从而创建额外的编码源。结合感兴趣的生物物理信号模型,可获得生物物理参数的加速和增强分辨率图。以三维采集中的可变翻转角信号模型为应用实例,通过布洛赫方程数值模拟、模型实验和体内实验验证并证明了这一点。使用体内数据进行了蒙特卡罗模拟,以研究我们方法的噪声性能。数值模型和现实数字脑模型的布洛赫方程数值模拟的 POSE 量化结果与参考方法一致,从理论和现实情况两方面验证了我们的方法。NIST 模体实验结果显示与参考方法的整体一致性极佳,证实了我们的方法适用于广泛的 T1 值范围。体内实验结果不仅与参考方法有很好的一致性,而且在相同加速度下的 g 因子也明显优于传统的并行成像方法。此外,我们的结果表明,POSE 可以与并行成像相结合,进一步加速,同时保持优于使用较低加速因子的并行成像的噪声性能。
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引用次数: 0
The impact of benign tissue within cancerous regions in the prostate: Characterizing sparse and dense prostate cancers on whole-mount histopathology and on multiparametric MRI 前列腺癌区域内良性组织的影响:通过全片组织病理学和多参数磁共振成像鉴定稀疏和致密前列腺癌的特征
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-10 DOI: 10.1016/j.mri.2024.110233
Olga Starobinets , Jeffry P. Simko , Matthew Gibbons , John Kurhanewicz , Peter R. Carroll , Susan M. Noworolski

Purpose

To establish the incidence, size, zonal location and Gleason Score(GS)/Gleason Grade Group(GG) of sparse versus dense prostate cancer (PCa) lesions and to identify the imaging characteristics of sparse versus dense cancers on multiparametric MRI (mpMRI).

Methods

Seventy-six men with untreated PCa were scanned prior to prostatectomy with endorectal-coil 3 T MRI including T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced MRI. Cancerous regions were outlined and graded on the whole-mount, processed specimens, with tissue compositions estimated. Regions with cancer comprising <50 % and ≥ 50 % of the tissue were considered sparse and dense respectively. Regions of interest (ROI) were manually drawn on T2-weighted MRI. Within each patient, area-weighted ROI averages were calculated for each imaging measure for each tissue type, GS/GG, and sparse/dense composition.

Results

A large number of cancer regions were identified on histopathology (n = 1193: 939 (peripheral zone (PZ)) and 254 (transition zone (TZ))). Thirty-seven percent of these lesions were sparse. Sparse lesions were primarily low-grade with the majority of PZ and 100 % of TZ sparse lesions ≤GS3 + 3/GG1. Dense lesions were significantly larger than sparse lesions in both PZ and TZ, p < 0.0001. On imaging, 246/45 PZ and 109/8 TZ dense/sparse 2D cancerous ROIs were drawn. Sparse GS3 + 3 and sparse ≥GS3 + 4 cancers did not have significantly different MRI intensities to dense GS3 + 3 cancers, while sparse GS3 + 3/GG1 cancers differed from benign, p < 0.05.

Conclusion

Histopathologically identified prostate cancer lesions were sparse in 37 % of cases. Sparse cancers were entirely low grade in TZ and predominantly low-grade in PZ and generally small, thus likely posing lower risk for spread and progression than dense lesions. Sparse lesions were not distinguishable from dense lesions on mpMRI, but could be distinguished from benign tissues.

目的 确定稀疏与致密前列腺癌(PCa)病变的发生率、大小、分区位置和格里森评分(GS)/格里森分级组(GG),并确定多参数磁共振成像(mpMRI)上稀疏与致密癌症的成像特征。方法 在前列腺切除术前,对76名未经治疗的PCa男性患者进行肛门直肠内线圈3 T磁共振成像扫描,包括T2加权成像、弥散加权成像和动态对比增强磁共振成像。在经过处理的整块标本上对癌变区域进行勾画和分级,并对组织成分进行估算。癌症占组织50%和≥50%的区域分别被视为稀疏区和致密区。在 T2 加权磁共振成像上手动绘制感兴趣区(ROI)。在每位患者体内,针对每种组织类型、GS/GG 和稀疏/致密成分的每种成像测量值,计算区域加权 ROI 平均值:939个(外周区(PZ)和254个(过渡区(TZ)))。这些病灶中有 37% 为稀疏病灶。稀疏病变主要是低级别病变,大多数 PZ 和 100% TZ 稀疏病变≤GS3 + 3/GG1。在 PZ 和 TZ 中,密集病灶明显大于稀疏病灶,P < 0.0001。在成像中,绘制了246/45个PZ和109/8个TZ致密/稀疏二维癌变ROI。稀疏GS3 + 3和稀疏≥GS3 + 4癌症的磁共振成像强度与致密GS3 + 3癌症无明显差异,而稀疏GS3 + 3/GG1癌症则与良性不同,p <0.05。稀疏癌在 TZ 中完全是低级别,在 PZ 中主要是低级别,而且一般较小,因此扩散和进展的风险可能低于致密病灶。稀疏病灶在 mpMRI 上无法与致密病灶区分开来,但可以与良性组织区分开来。
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引用次数: 0
Introducing article numbering to Magnetic Resonance Imaging 在磁共振成像中引入文章编号
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-09 DOI: 10.1016/S0730-725X(24)00210-8
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引用次数: 0
Insertable, dual-density dielectric barrier for acoustic pressure level reduction in a high-performance human head-only MRI system 用于降低高性能人体头部磁共振成像系统声压级的可插入式双密度介质屏障。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-09-02 DOI: 10.1016/j.mri.2024.110224
S.-K. Lee, Matthew R. Tarasek, Keith Park, Desmond T.-B. Yeo, Thomas K.-F. Foo

We report use of a dual-density dielectric barrier surrounding a detachable high-pass radiofrequency (RF) birdcage coil to achieve an order-of-magnitude reduction of acoustic noise in a high-performance head gradient system. The barrier consisted of a 4.5 mm-thick mass-loaded vinyl and a 6 mm-thick polyurethane foam. It was inserted into the radial gap between the birdcage coil and the RF shield in a prototype head-only gradient system at 3 T. More than 9 dBA reduction of sound pressure level was achieved on the average with representative, high acoustic-noise imaging sequences. Increased acoustic damping was apparent from acoustic impulse response functions. High dielectric constant of the mass-loaded vinyl effectively added distributed capacitance to the birdcage coil, lowering the resonance frequency, but not seriously degrading the RF transmission performance. The barrier occupied the radial space normally used for air cooling of the RF coil and the RF shield. The resulting omission of air cooling was found to be acceptable with efficient gradient thermal management and use of a high-resistivity RF shield for eddy current reduction. The proposed method can improve patient experience while preserving image quality in a high-power head-only gradient system.

我们报告了在可拆卸的高通射频(RF)鸟笼线圈周围使用双密度介质屏障,从而在高性能头部梯度系统中实现了数量级的声噪降低。屏障由 4.5 毫米厚的大质量乙烯基和 6 毫米厚的聚氨酯泡沫组成。在 3 T 的原型头部梯度系统中,将其插入鸟笼线圈和射频屏蔽之间的径向间隙。在具有代表性的高声噪成像序列中,声压级平均降低了 9 分贝以上。从声学脉冲响应函数中可以明显看到声学阻尼的增加。质量负载乙烯基的高介电常数有效地增加了鸟笼线圈的分布电容,降低了共振频率,但并没有严重降低射频传输性能。阻挡层占据了通常用于对射频线圈和射频屏蔽进行空气冷却的径向空间。通过有效的梯度热管理和使用高电阻率射频屏蔽以减少涡流,发现省去空气冷却是可以接受的。所提出的方法可以改善患者的就医体验,同时保持大功率纯头部梯度系统的图像质量。
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引用次数: 0
Inter-visit and inter-reader reproducibility of multi-parametric diffusion-weighted MR imaging in longitudinally imaged patients with metabolic dysfunction-associated fatty liver disease and healthy volunteers. 对代谢功能障碍相关脂肪肝患者和健康志愿者进行纵向成像的多参数弥散加权磁共振成像的就诊间和阅片员间重现性。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-23 DOI: 10.1016/j.mri.2024.110223
Anton Volniansky , Thierry L. Lefebvre , Merve Kulbay , Boyan Fan , Emre Aslan , Kim-Nhien Vu , Emmanuel Montagnon , Bich Ngoc Nguyen , Giada Sebastiani , Jeanne-Marie Giard , Marie-Pierre Sylvestre , Guillaume Gilbert , Guy Cloutier , An Tang

Background

Despite the widespread use of diffusion-weighted imaging (DWI) in metabolic dysfunction-associated fatty liver disease (MAFLD), MRI acquisition and quantification techniques vary in the literature suggesting the need for established and reproducible protocols. The goal of this study was to assess inter-visit and inter-reader reproducibility of DWI- and IVIM-derived parameters in patients with MAFLD and healthy volunteers using extensive sampling of the “fast” compartment, non-rigid registration, and exclusion voxels with poor fit quality.

Methods

From June 2019 to April 2023, 31 subjects (20 patients with biopsy-proven MAFLD and 11 healthy volunteers) were included in this IRB-approved study. Subjects underwent MRI examinations twice within 40 days. 3.0 T DWI was acquired using a respiratory-triggered spin-echo diffusion-weighted echo-planar imaging sequence (b-values of 0, 10, 20, 30, 40, 50, 100, 200, 400, 800 s/mm2). DWI series were co-registered prior to voxel-wise non-linear regression of the IVIM model and voxels with poor fit quality were excluded (normalized root mean squared error ≥ 0.05). IVIM parameters (perfusion fraction, f; diffusion coefficient, D; and pseudo-diffusion coefficient, D*), and apparent diffusion coefficients (ADC) were computed from manual segmentation of the right liver lobe performed by two analysts on two MRI examinations.

Results

All results are reported for f, D, D*, and ADC respectively. For inter-reader agreement on the first visit, ICC were of 0.985, 0.994, 0.986, and 0.993 respectively. For intra-reader agreement of analyst 1 assessed on both imaging examinations, ICC between visits were of 0.805, 0.759, 0.511, and 0.850 respectively. For inter-reader agreement on the first visit, mean bias and 95 % limits of agreement were (0.00 ± 0.03), (−0.01 ± 0.03) × 10−3 mm2/s, (0.70 ± 10.40) × 10−3 mm2/s, and (−0.02 ± 0.04) × 10−3 mm2/s respectively. For intra-reader agreement of analyst 1, mean bias and 95 % limits of agreement were (0.01 ± 0.09) × 10−3 mm2/s, (−0.01 ± 0.21) × 10−3 mm2/s, (−13.37 ± 56.19) × 10−3 mm2/s, and (−0.01 ± 0.16) × 10−3 mm2/s respectively. Except for parameter D* that was associated with between-subjects parameter variability (P = 0.009), there was no significant variability between subjects, examinations, or readers.

Conclusion

With our approach, IVIM parameters f, D, D*, and ADC provided excellent inter-reader agreement and good to very good inter-visit or intra-reader agreement, thus showing the reproducibility of IVIM-DWI of the liver in MAFLD patients and volunteers.

背景:尽管弥散加权成像(DWI)在代谢功能障碍相关性脂肪肝(MAFLD)中得到了广泛应用,但文献中的磁共振成像采集和量化技术却各不相同,这表明需要制定可重复的既定方案。本研究的目的是利用对 "快速 "区块的广泛采样、非刚性注册和排除拟合质量差的体素,评估MAFLD患者和健康志愿者的DWI和IVIM衍生参数的访问间和阅读者间的可重复性:从 2019 年 6 月到 2023 年 4 月,31 名受试者(20 名经活检证实的 MAFLD 患者和 11 名健康志愿者)参加了这项经 IRB 批准的研究。受试者在 40 天内接受了两次核磁共振成像检查。使用呼吸触发自旋回波扩散加权回声平面成像序列(b 值为 0、10、20、30、40、50、100、200、400、800 s/mm2)采集 3.0 T DWI。在对 IVIM 模型进行体素非线性回归之前,对 DWI 序列进行了共同注册,并排除了拟合质量较差的体素(归一化均方根误差≥ 0.05)。IVIM 参数(灌注分数,f;扩散系数,D;伪扩散系数,D*)和表观扩散系数(ADC)由两名分析师在两次 MRI 检查中对右肝叶进行手动分割计算得出:结果:报告的所有结果分别为 f、D、D* 和 ADC。对于首次检查的读片者之间的一致性,ICC 分别为 0.985、0.994、0.986 和 0.993。在两次成像检查中评估分析师 1 的阅片员内部一致性时,两次检查之间的 ICC 分别为 0.805、0.759、0.511 和 0.850。对于第一次检查的阅片员之间的一致性,平均偏差和 95 % 的一致性限值分别为 (0.00±0.03)、(-0.01±0.03) × 10-3 mm2/s、(0.70±10.40) × 10-3 mm2/s 和 (-0.02±0.04) × 10-3 mm2/s。在分析仪 1 的读数一致性方面,平均偏差和 95 % 的一致性限值分别为 (0.01 ± 0.09) × 10-3 mm2/s、(-0.01 ± 0.21) × 10-3 mm2/s、(-13.37 ± 56.19) × 10-3 mm2/s、(-0.01 ± 0.16) × 10-3 mm2/s。除了参数 D* 与受试者之间的参数变异有关(P = 0.009)外,受试者、检查或阅读者之间没有明显的变异:采用我们的方法,IVIM 参数 f、D、D* 和 ADC 在阅读器之间具有极好的一致性,在检查或阅读器内部具有良好到非常好的一致性,从而显示了 MAFLD 患者和志愿者肝脏 IVIM-DWI 的可重复性。
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引用次数: 0
Longitudinal registration of T1-weighted breast MRI: A registration algorithm (FLIRE) and clinical application T1 加权乳腺 MRI 的纵向配准:配准算法(FLIRE)及临床应用。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-22 DOI: 10.1016/j.mri.2024.110222
Michelle W. Tong , Hon J. Yu , Maren M. Sjaastad Andreassen , Stephane Loubrie , Ana E. Rodríguez-Soto , Tyler M. Seibert , Rebecca Rakow-Penner , Anders M. Dale

Purpose

MRI is commonly used to aid breast cancer diagnosis and treatment evaluation. For patients with breast cancer, neoadjuvant chemotherapy aims to reduce the tumor size and extent of surgery necessary. The current clinical standard to measure breast tumor response on MRI uses the longest tumor diameter. Radiologists also account for other tissue properties including tumor contrast or pharmacokinetics in their assessment. Accurate longitudinal image registration of breast tissue is critical to properly compare response to treatment at different timepoints.

Methods

In this study, a deformable Fast Longitudinal Image Registration (FLIRE) algorithm was optimized for breast tissue. FLIRE was then compared to the publicly available software packages with high accuracy (DRAMMS) and fast runtime (Elastix). Patients included in the study received longitudinal T1-weighted MRI without fat saturation at two to six timepoints as part of asymptomatic screening (n = 27) or throughout neoadjuvant chemotherapy treatment (n = 32). T1-weighted images were registered to the first timepoint with each algorithm.

Results

Alignment and runtime performance were compared using two-way repeated measure ANOVAs (P < 0.05). Across all patients, Pearson's correlation coefficient across the entire image volume was slightly higher with statistical significance and had less variance for FLIRE (0.98 ± 0.01 stdev) compared to DRAMMS (0.97 ± 0.03 stdev) and Elastix (0.95 ± 0.03 stdev). Additionally, FLIRE runtime (10.0 mins) was 9.0 times faster than DRAMMS (89.6 mins) and 1.5 times faster than Elastix (14.5 mins) on a Linux workstation.

Conclusion

FLIRE demonstrates promise for time-sensitive clinical applications due to its accuracy, robustness across patients and timepoints, and speed.

目的:磁共振成像通常用于辅助乳腺癌诊断和治疗评估。对于乳腺癌患者来说,新辅助化疗的目的是缩小肿瘤大小,减少手术范围。目前在核磁共振成像上测量乳腺肿瘤反应的临床标准是使用最长的肿瘤直径。放射医师在评估时还会考虑其他组织特性,包括肿瘤对比度/药代动力学。准确的乳腺组织纵向图像配准对于正确比较不同时间点的治疗反应至关重要:本研究针对乳腺组织优化了可变形快速纵向图像配准(FLIRE)算法。然后将 FLIRE 与高精度(DRAMMS)和快速运行(Elastix)的公开软件包进行比较。作为无症状筛查(27 例)或整个新辅助化疗过程(32 例)的一部分,参与研究的患者在 2 到 6 个时间点接受了无脂肪饱和的纵向 T1 加权磁共振成像。每种算法的 T1 加权图像均登记到第一个时间点:结果:使用双向重复测量方差分析比较了对准和运行时间性能(PFLIRE 具有准确性、跨患者和时间点的鲁棒性以及速度快等优点,有望用于时间敏感型临床应用。
{"title":"Longitudinal registration of T1-weighted breast MRI: A registration algorithm (FLIRE) and clinical application","authors":"Michelle W. Tong ,&nbsp;Hon J. Yu ,&nbsp;Maren M. Sjaastad Andreassen ,&nbsp;Stephane Loubrie ,&nbsp;Ana E. Rodríguez-Soto ,&nbsp;Tyler M. Seibert ,&nbsp;Rebecca Rakow-Penner ,&nbsp;Anders M. Dale","doi":"10.1016/j.mri.2024.110222","DOIUrl":"10.1016/j.mri.2024.110222","url":null,"abstract":"<div><h3>Purpose</h3><p>MRI is commonly used to aid breast cancer diagnosis and treatment evaluation. For patients with breast cancer, neoadjuvant chemotherapy aims to reduce the tumor size and extent of surgery necessary. The current clinical standard to measure breast tumor response on MRI uses the longest tumor diameter. Radiologists also account for other tissue properties including tumor contrast or pharmacokinetics in their assessment. Accurate longitudinal image registration of breast tissue is critical to properly compare response to treatment at different timepoints.</p></div><div><h3>Methods</h3><p>In this study, a deformable Fast Longitudinal Image Registration (FLIRE) algorithm was optimized for breast tissue. FLIRE was then compared to the publicly available software packages with high accuracy (DRAMMS) and fast runtime (Elastix). Patients included in the study received longitudinal T<sub>1</sub><sub>-</sub>weighted MRI without fat saturation at two to six timepoints as part of asymptomatic screening (<em>n</em> = 27) or throughout neoadjuvant chemotherapy treatment (<em>n</em> = 32). T<sub>1</sub><sub>-</sub>weighted images were registered to the first timepoint with each algorithm.</p></div><div><h3>Results</h3><p>Alignment and runtime performance were compared using two-way repeated measure ANOVAs (<em>P</em> &lt; 0.05). Across all patients, Pearson's correlation coefficient across the entire image volume was slightly higher with statistical significance and had less variance for FLIRE (0.98 ± 0.01 stdev) compared to DRAMMS (0.97 ± 0.03 stdev) and Elastix (0.95 ± 0.03 stdev). Additionally, FLIRE runtime (10.0 mins) was 9.0 times faster than DRAMMS (89.6 mins) and 1.5 times faster than Elastix (14.5 mins) on a Linux workstation.</p></div><div><h3>Conclusion</h3><p>FLIRE demonstrates promise for time-sensitive clinical applications due to its accuracy, robustness across patients and timepoints, and speed.</p></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"113 ","pages":"Article 110222"},"PeriodicalIF":2.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0730725X24002030/pdfft?md5=3a8823f570ed73e6dfad0e0fd6b7ec98&pid=1-s2.0-S0730725X24002030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic contrast enhanced MRI of the head and neck region using a VIBE sequence with Cartesian undersampling and compressed sensing 使用笛卡尔欠采样和压缩传感的 VIBE 序列进行头颈部动态对比增强磁共振成像。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-08-22 DOI: 10.1016/j.mri.2024.110220
F. Kubicka , L. Nitschke , T. Penzkofer , Q. Tan , M.D. Nickel , K.M. Wakonig , U.L. Fahlenkamp , M. Lerchbaumer , F. Michallek , S. Dommerich , B. Hamm , M. Wagner , T. Walter-Rittel

Objectives

Compressed sensing allows for image reconstruction from sparsely sampled k-space data, which is particularly useful in dynamic contrast enhanced MRI (DCE-MRI). The aim of the study was to assess the diagnostic value of a volume-interpolated 3D T1-weighted spoiled gradient-echo sequence with variable density Cartesian undersampling and compressed sensing (CS) for head and neck MRI.

Methods

Seventy-one patients with clinical indications for head and neck MRI were included in this study. DCE-MRI was performed at 3 Tesla magnet using CS-VIBE (variable density undersampling, temporal resolution 3.4 s, slice thickness 1 mm). Image quality was compared to standard Cartesian VIBE. Three experienced readers independently evaluated image quality and lesion conspicuity on a 5-point Likert scale and determined the DCE-derived time intensity curve (TIC) types.

Results

CS-VIBE demonstrated higher image quality scores compared to standard VIBE with respect to overall image quality (4.3 ± 0.6 vs. 4.2 ± 0.7, p = 0.682), vessel contour (4.6 ± 0.4 vs. 4.4 ± 0.6, p < 0.001), muscle contour (4.4 ± 0.5 vs. 4.5 ± 0.6, p = 0.302), lesion conspicuity (4.5 ± 0.7 vs. 4.3 ± 0.9, p = 0.024) and showed improved fat saturation (4.8 ± 0.3 vs. 3.8 ± 0.4, p < 0.001) and movement artifacts were significantly reduced (4.6 ± 0.6 vs. 3.7 ± 0.7, p < 0.001). Standard VIBE outperformed CS-VIBE in the delineation of pharyngeal mucosa (4.2 ± 0.5 vs. 4.6 ± 0.6, p < 0.001). Lesion size in cases where a focal lesion was identified was similar for all readers for CS-VIBE and standard VIBE (p = 0.101). TIC curve assessment showed good interobserver agreement (k=0.717).

Conclusion

CS-VIBE with variable density Cartesian undersampling allows for DCE-MRI of the head and neck region with diagnostic, high image quality and high temporal resolution.

目的:压缩传感技术可从稀疏采样的 k 空间数据中重建图像,尤其适用于动态对比增强磁共振成像(DCE-MRI)。该研究旨在评估采用可变密度笛卡尔欠采样和压缩传感(CS)的体积内插三维 T1 加权破坏梯度回波序列对头颈部 MRI 的诊断价值:本研究纳入了71名具有头颈部磁共振成像临床指征的患者。使用 CS-VIBE(可变密度欠采样,时间分辨率 3.4 秒,切片厚度 1 毫米)在 3 特斯拉磁体上进行了 DCE-MRI。图像质量与标准笛卡尔 VIBE 进行了比较。三位经验丰富的读者以 5 点李克特量表独立评估图像质量和病变的清晰度,并确定 DCE 衍生的时间强度曲线 (TIC) 类型:结果:与标准 VIBE 相比,CS-VIBE 在总体图像质量(4.3 ± 0.6 vs. 4.2 ± 0.7,p = 0.682)、血管轮廓(4.6 ± 0.4 vs. 4.4 ± 0.6,p 结论:CS-VIBE 的图像质量得分高于标准 VIBE:采用可变密度笛卡尔欠采样的 CS-VIBE 可对头颈部进行 DCE-MRI 检查,具有诊断性强、图像质量高和时间分辨率高的特点。
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引用次数: 0
期刊
Magnetic resonance imaging
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