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Bilateral Brachial Plexus Block Using Chloroprocaine For Surgery Of Bilateral Radial Fractures 氯丙卡因用于双侧臂丛阻滞治疗双侧桡骨骨折
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-09-01 DOI: 10.2147/LRA.S225471
Chanchal Mangla, H. Kamath, J. Yarmush
Abstract We report a case of a 41-year-old male with anticipated difficult airway undergoing a repair of a bilateral radial fracture under bilateral sequential brachial plexus block. Anesthesiologists are reluctant to perform bilateral blocks because of the fear of complications like diaphragmatic paralysis, local anesthetic (LA) toxicity, and pneumothorax. We advise that with the correct application of LA pharmacokinetics, careful patient selection and usage of ultrasound, bilateral blocks can be done safely. We used chloroprocaine as an LA in one of the blocks to reduce the dose required for the more toxic LAs. chloroprocaine’s fast metabolism also helped us to prevent the overlapping of peak plasma concentration of different LAs. To our knowledge, this is the first reported case in the literature where chloroprocaine was used for bilateral brachial plexus block.
摘要我们报告一例41岁男性,预期气道困难,在双侧臂丛神经阻滞下接受双侧桡骨骨折的修复。麻醉师不愿意进行双侧阻滞,因为担心并发症,如膈肌麻痹、局部麻醉剂(LA)毒性和肺气肿。我们建议,通过正确应用左心房药代动力学,仔细选择患者并使用超声,可以安全地进行双侧阻断。我们在其中一个区块中使用氯普鲁卡因作为LA,以减少毒性更强的LA所需的剂量。氯普鲁卡因的快速代谢也有助于我们防止不同LA的峰值血浆浓度重叠。据我们所知,这是文献中首次报道氯普鲁卡因用于双侧臂丛神经阻滞的病例。
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引用次数: 3
Effect of bupivacaine and adjuvant drugs on skeletal muscle tissue oximetry and blood flow: an experimental study 布比卡因及辅助药物对骨骼肌组织血氧测定和血流量影响的实验研究
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-08-29 DOI: 10.2147/LRA.S203569
A. Schubert, S. Müller, H. Wulf, T. Steinfeldt, T. Wiesmann
Background Skeletal muscle microvascular blood flow plays a critical role in many myopathologies. The influence of bupivacaine and adjuvants on skeletal muscle microvascular perfusion and tissue oximetry is poorly understood but might be a relevant risk factor for myopathies after local anesthetic administration. The aim of this experimental study was to determine the effects of bupivacaine alone or in combination with epinephrine or clonidine on skeletal muscle perfusion and tissue oximetry. Methods Combined tissue spectrophotometry and Laser-Doppler flowmetry and tissue oximetry were used to assess local muscle blood flow in anesthetized pigs after topical administration of test solutions (bupivacaine, bupivacaine with epinephrine or clonidine, saline). Measurements were performed for up to 60 mins. Results The application of bupivacaine alone did not alter relative muscle blood flow significantly, whereas the addition of epinephrine or clonidine to bupivacaine resulted in a significant reduction of relative muscle blood flow at T30 and T60. However, bupivacaine resulted in a significant decrease of tissue oximetry values when compared to saline control group at T30 and T60. The application of bupivacaine combined with clonidine or epinephrine resulted in no significant reduction of tissue oximetry when compared to bupivacaine alone. Conclusion Bupivacaine alone results in a significant decrease of tissue oximetry in skeletal muscle which is not increased by the addition of epinephrine or clonidine despite further reductions of microcirculatory perfusion. Overall, bupivacaine alone or with adjuvants does produce local muscle ischemia for which pathological consequences need to be addressed in further studies.
背景骨骼肌微血管血流在许多肌病中起着至关重要的作用。布比卡因和佐剂对骨骼肌微血管灌注和组织血氧测定的影响尚不清楚,但可能是局部麻醉后肌病的相关风险因素。本实验研究的目的是确定布比卡因单独或与肾上腺素或可乐定联合使用对骨骼肌灌注和组织血氧测定的影响。方法采用组织分光光度法、激光多普勒血流测定法和组织血氧计相结合的方法,对麻醉猪局部注射试验溶液(布比卡因、布比卡因加肾上腺素或可乐定、生理盐水)后的局部肌肉血流量进行评估。测量时间长达60分钟。结果单独应用布比卡因不会显著改变相对肌肉血流量,而在T30和T60时,在布比卡因中加入肾上腺素或可乐定会显著降低相对肌肉血流速。然而,在T30和T60时,与生理盐水对照组相比,布比卡因导致组织血氧测定值显著降低。与单独使用布比卡因相比,布比卡因与可乐定或肾上腺素联合使用并没有显著降低组织血氧饱和度。结论单独使用布比卡因可显著降低骨骼肌组织血氧饱和度,尽管微循环灌注进一步减少,但加入肾上腺素或可乐定并不能增加组织血氧饱和度。总的来说,布比卡因单独或与佐剂一起确实会产生局部肌肉缺血,其病理后果需要在进一步的研究中解决。
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引用次数: 0
Long-term placement of continuous popliteal nerve block catheter for management of a wounded patient in a combat field environment: a case report. 长期放置连续腘神经阻滞导管治疗战场环境中受伤患者一例报告。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-08-29 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S210462
Costantino Fontana, Monica Rocco, Luigi Vetrugno, Elena Bignami

Continuous peripheral nerve block is a relevant part of multimodal treatment of postoperative pain. In this context the continuous popliteal nerve block is described as an option for postoperative pain management for surgical procedures on the leg, and particularly on the ankle and foot. We applied continuous popliteal nerve block for different types of anesthesia and postoperative pain management via the same catheter. No clear evidence of this specific use has been described in the literature. A 38 year-old patient wounded in combat with a displaced fracture of left tibia and extensive loss of substance needed orthopedic surgeries as well as several reconstructive procedures. A continuous popliteal nerve block was applied via ultrasound-guided catheter for anesthesia at different times, and postoperative pain control for all surgical procedures. The continuous popliteal nerve block and its long-term positioning, of non-common evidence in literature, was utilized to treat a poly-traumatized patient, thereby avoiding repeated general anesthesia and opioid use and their adverse effects. This technique, within a complicated combat field environment, was demonstrated to be clinically effective with high patient satisfaction.

持续周围神经阻滞是术后疼痛多模式治疗的重要组成部分。在这种情况下,连续腘神经阻滞被描述为腿部外科手术后疼痛管理的一种选择,特别是在脚踝和足部。我们通过同一导管应用连续腘神经阻滞用于不同类型的麻醉和术后疼痛管理。文献中没有明确的证据说明这种特殊用途。一名38岁的患者在战斗中受伤,左胫骨移位性骨折并大面积丢失,需要进行骨科手术和几次重建手术。超声引导导管连续阻滞腘窝神经,在不同时间麻醉,并对所有手术过程进行术后疼痛控制。利用文献中不常见的腘神经连续阻滞及其长期定位治疗多处创伤患者,避免了反复全身麻醉和阿片类药物的使用及其不良反应。在复杂的战场环境中,该技术被证明是临床有效的,患者满意度高。
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引用次数: 0
Impact of serratus plane block on pain scores and incentive spirometry volumes after chest trauma 胸外伤后锯肌平面阻滞对疼痛评分和刺激肺活量的影响
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-08-01 DOI: 10.2147/LRA.S207791
Nadia Hernandez, J. D. de Haan, Dallis Clendenin, D. Meyer, Semhar J. Ghebremichael, C. Artime, George Williams, H. Eltzschig, S. Sen
Background: Adequate pain control is difficult to achieve in patients with multiple rib fractures (MRF). Serratus plane block (SPB) is a novel technique for alleviating rib fracture pain. Several published case reports support this hypothesis. Purpose: The purpose of this study was to evaluate the use of SPB in MRF at our level 1 trauma center. Methods: Our hospital’s Regional Anesthesia Registry was queried for all trauma patients with MRF who underwent SPB between August 2014 and January 2018. Data were compared in each patient as a matched pair for the time periods before and after undergoing SPB. Thirty-four patients with similar baseline characteristics were enrolled. Results: The median number of rib fractures was 7. Ordinal pain scores were found to be improved 4 hrs after SPB from median 7/10 to 3/10 (P<0.001). Incentive spirometry (IS) volumes recorded 4 and 24 hrs postserratus plane block showed a median increase of 150 and 175 mL from baseline, respectively (P<0.001). IS volumes recorded at 48 hrs showed a median increase of 300 mL from baseline (P<0.001). Respiratory rate decreased from a median value of 24.5 to 16 breaths/min (P<0.001). SpO2 was improved at 24 hrs from median 96% to 99% (P<0.001). Conclusion: SPB improves pain scores and IS volumes in MRF. Because it is not limited by patient positioning or anticoagulation and has a better safety profile, it may offer a viable alternative to neuraxial techniques. Additional studies are necessary to evaluate its efficacy compared to neuraxial techniques.
背景:多发性肋骨骨折(MRF)患者很难实现充分的疼痛控制。Serratus平面阻滞(SPB)是一种新型的缓解肋骨骨折疼痛的技术。一些已发表的案例报告支持这一假设。目的:本研究旨在评估SPB在我们一级创伤中心MRF中的应用。方法:查询2014年8月至2018年1月期间接受SPB的所有MRF创伤患者的医院区域麻醉登记处。将每位患者在接受SPB前后的时间段内的数据作为匹配对进行比较。34名具有相似基线特征的患者被纳入研究。结果:肋骨骨折的中位数为7。SPB后4小时,常规疼痛评分从中位数7/10提高到3/10(P<0.001)。刺激性肺活量测定术(IS)记录的4小时和24小时后平面阻滞的容积显示,中位数比基线增加了150和175 mL,分别为(P<0.001)。48小时记录的IS体积比基线增加了300mL(P<0.01)。呼吸频率从24.5的中值降至16次呼吸/分钟(P<001)。SpO2在24小时从中值96%提高到99%(P<.001)。结论:SPB改善了MRF中的疼痛评分和IS体积。因为它不受患者定位或抗凝治疗的限制,并且具有更好的安全性,它可能为神经轴技术提供一种可行的替代方案。与神经轴技术相比,有必要进行更多的研究来评估其疗效。
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引用次数: 15
Improving intraoperative handoffs for ambulatory anesthesia: challenges and solutions for the anesthesiologist [Corrigendum]. 改善门诊麻醉的术中交接:麻醉师的挑战和解决方案[勘误]。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-07-01 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S217891
On page 38, Table 1, Summary of principal findings row, column 4 the text “(odds ratio 0.95, 95% CI 9.895 to 1.022, P=0.19)” should read “(odds ratio 0.95, 95% CI 0.895 to 1.022, P=0.19)” (i.e., change 9.985 to 0.895) and “(0.933, 95% CI 0.890–9.977, P<0.0001)” should read “(0.933, 95% CI 0.890–0.977, P<0.0001)” (i.e., change 9.977 to 0.977). On page 39, column 2, paragraph 3, the matching change to the text is for “(adjusted odds ratio 0.95, 95% CI 9.895–1.022, P=0.19)” to be “(adjusted odds ratio 0.95, 95% CI 0.895–1.022, P=0.19)” and “(odds ratio=0.933, 95% CI 0.890–9.977, P<0.0001)” to be “(odds ratio=0.933, 95% CI 0.890–0.977, P<0.0001)”.
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引用次数: 0
Effect of hypotensive hypovolemia and thoracic epidural anesthesia on plasma pro-atrial natriuretic peptide to indicate deviations in central blood volume in pigs: a blinded, randomized controlled trial 低血压低血容量和胸段硬膜外麻醉对血浆心房钠素前肽的影响,以指示猪中心血容量的偏差:一项盲法、随机对照试验
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-06-01 DOI: 10.2147/LRA.S204594
R. Strandby, R. Ambrus, M. Achiam, Amalie Henriksen, J. Goetze, N. Secher, L. Svendsen
Purpose Changes in plasma pro-atrial natriuretic peptide (proANP) may indicate deviations in the central blood volume (CBV). We evaluated the plasma proANP response to hypotensive hypovolemia under the influence of thoracic epidural anesthesia (TEA) in pigs. We hypothesized that plasma proANP would decrease in response to hypotensive hypovolemia and that TEA would aggravate the proANP response, reflecting a further decrease in CBV. Design Randomized, blinded, controlled trial. Setting A university-affiliated experimental facility. Participants Twenty pigs randomized to administration of saline (placebo) or bupivacaine with morphine (TEA) in the epidural space at Th8-Th10. Interventions Relative hypovolemia was established by an inflatable Foley catheter positioned in the inferior caval vein just below the heart (caval obstruction), and hemorrhage-induced hypovolemia was by withdrawal of blood from the femoral artery, both aiming at a mean arterial pressure (MAP) of 50–60 mmHg. Hemodynamic variables and plasma proANP were determined before and after the interventions. Results Caval obstruction and withdrawal of blood reduced MAP to 50–60 mmHg. Accordingly, cardiac output, central venous pressure, and mixed venous oxygen saturation decreased (p<0.05). Yet, plasma proANP was stable after both caval obstruction (TEA: 72 [63–78] to 80 pmol/L [72–85], p=0.09 and placebo: 64 [58–76] to 69 pmol/L [57–81], p=0.06) and withdrawal of blood (TEA: 74 [73–83] to 79 pmol/L [77–87], p=0.07 and placebo: 64 [56–77] to 67 pmol/L [58–78], p=0.15). Conclusion Plasma proANP was stable in response to relative and hemorrhage-induced hypovolemia to a MAP of 50–60 mmHg, and the response was independent of TEA. The findings suggest that alterations in plasma proANP do not follow deviations in CBV during hypotensive hypovolemia in pigs.
目的血浆心房钠素前肽(proANP)的变化可能提示中枢血容量(CBV)的偏差。我们评估了胸段硬膜外麻醉(TEA)对猪低血压低血容量的影响下血浆proANP的反应。我们假设血浆proANP会因低血压低血容量而降低,而TEA会加重proANP反应,反映出CBV的进一步降低。设计随机、盲法、对照试验。大学附属实验设施。20头猪随机分为两组,在Th8-Th10时在硬膜外腔给予生理盐水(安慰剂)或布比卡因加吗啡(TEA)。干预措施:将充气Foley导管置于心脏正下方的下腔静脉(腔静脉梗阻),建立相对低血容量;从股动脉抽血,建立出血性低血容量,均将平均动脉压(MAP)控制在50-60 mmHg。测定干预前后血流动力学指标和血浆proANP。结果腔静脉梗阻及抽血使MAP降至50 ~ 60 mmHg。心输出量、中心静脉压、混合静脉氧饱和度降低(p<0.05)。然而,在腔静脉梗阻(TEA: 72[63-78]至80 pmol/L [72 - 85], p=0.09,安慰剂:64[58-76]至69 pmol/L [57-81], p=0.06)和退血(TEA: 74[73-83]至79 pmol/L [77-87], p=0.07,安慰剂:64[56-77]至67 pmol/L [58-78], p=0.15)后,血浆proANP均保持稳定。结论血浆proANP对相对低血容量和出血性低血容量的反应在MAP为50 ~ 60 mmHg时较为稳定,且与TEA无关。研究结果表明,猪在低血压低血容量时血浆proANP的改变不随CBV的变化而变化。
{"title":"Effect of hypotensive hypovolemia and thoracic epidural anesthesia on plasma pro-atrial natriuretic peptide to indicate deviations in central blood volume in pigs: a blinded, randomized controlled trial","authors":"R. Strandby, R. Ambrus, M. Achiam, Amalie Henriksen, J. Goetze, N. Secher, L. Svendsen","doi":"10.2147/LRA.S204594","DOIUrl":"https://doi.org/10.2147/LRA.S204594","url":null,"abstract":"Purpose Changes in plasma pro-atrial natriuretic peptide (proANP) may indicate deviations in the central blood volume (CBV). We evaluated the plasma proANP response to hypotensive hypovolemia under the influence of thoracic epidural anesthesia (TEA) in pigs. We hypothesized that plasma proANP would decrease in response to hypotensive hypovolemia and that TEA would aggravate the proANP response, reflecting a further decrease in CBV. Design Randomized, blinded, controlled trial. Setting A university-affiliated experimental facility. Participants Twenty pigs randomized to administration of saline (placebo) or bupivacaine with morphine (TEA) in the epidural space at Th8-Th10. Interventions Relative hypovolemia was established by an inflatable Foley catheter positioned in the inferior caval vein just below the heart (caval obstruction), and hemorrhage-induced hypovolemia was by withdrawal of blood from the femoral artery, both aiming at a mean arterial pressure (MAP) of 50–60 mmHg. Hemodynamic variables and plasma proANP were determined before and after the interventions. Results Caval obstruction and withdrawal of blood reduced MAP to 50–60 mmHg. Accordingly, cardiac output, central venous pressure, and mixed venous oxygen saturation decreased (p<0.05). Yet, plasma proANP was stable after both caval obstruction (TEA: 72 [63–78] to 80 pmol/L [72–85], p=0.09 and placebo: 64 [58–76] to 69 pmol/L [57–81], p=0.06) and withdrawal of blood (TEA: 74 [73–83] to 79 pmol/L [77–87], p=0.07 and placebo: 64 [56–77] to 67 pmol/L [58–78], p=0.15). Conclusion Plasma proANP was stable in response to relative and hemorrhage-induced hypovolemia to a MAP of 50–60 mmHg, and the response was independent of TEA. The findings suggest that alterations in plasma proANP do not follow deviations in CBV during hypotensive hypovolemia in pigs.","PeriodicalId":18203,"journal":{"name":"Local and Regional Anesthesia","volume":"12 1","pages":"47 - 55"},"PeriodicalIF":2.9,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/LRA.S204594","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48199316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Improving intraoperative handoffs for ambulatory anesthesia: challenges and solutions for the anesthesiologist. 改善门诊麻醉的术中交接:麻醉师面临的挑战和解决方案。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-05-24 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S183188
Franklin Dexter, Brian Mark Osman, Richard H Epstein

Permanent transitions of care from one anesthesia provider to another are associated with adverse events and mortality. There are currently no available data on how to mitigate these poor patient outcomes other than to reduce the occurrence of such handoffs. We used data from an ambulatory surgery center to demonstrate the steps that can be taken to achieve this goal. First, perform statistical forecasting using many months of historical data to create optimal, as opposed to arbitrary shift durations. Second, consider assigning the anesthesia providers designated to work late, if necessary, to the ORs estimated to finish the earliest, rather than latest. We performed multiple analyses showing the quantitative advantage of this strategy for the ambulatory surgery center with multiple brief cases. Third, sequence the cases in the 1 or 2 ORs with the latest scheduled end times so that the briefest cases are finished last. If a supervising anesthesiologist needs to be relieved early for administrative duties (eg, head of the group to meet with administrators or surgeons), assign the anesthesiologist to an OR that finishes with several brief cases. The rationale for these recommendations is that such strategies provide multiple opportunities for a different anesthesia provider to assume responsibility for the patients between cases, thus avoiding a handoff altogether.

从一名麻醉提供者到另一名麻醉提供者的永久性转移与不良事件和死亡率有关。除了减少这种交接的发生外,目前还没有关于如何减轻这些不良患者预后的可用数据。我们使用了一个流动手术中心的数据来演示可以采取的步骤来实现这一目标。首先,使用多个月的历史数据执行统计预测,以创建最优值,而不是任意移动持续时间。第二,如有必要,考虑将指定工作到很晚的麻醉提供者分配到预计最早而不是最晚完成的手术室。我们进行了多项分析,显示了该策略在门诊手术中心的数量优势。第三,将1或2个手术室中的案例按最近的计划结束时间排序,以便最后完成最简短的案例。如果督导麻醉师需要提前解除行政职责(例如,组长会见行政人员或外科医生),将麻醉师分配到完成几个简短病例的手术室。这些建议的基本原理是,这种策略为不同的麻醉提供者提供了多种机会,可以在不同的病例之间承担病人的责任,从而避免了完全的交接。
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引用次数: 4
Comparison of subcutaneous dexmedetomidine versus clonidine as an adjuvant to spinal anesthesia: a randomized double blind control trial. 皮下右美托咪定与可乐定作为脊髓麻醉辅助剂的比较:一项随机双盲对照试验。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-04-05 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S197386
Divya B Srinivas, Geetha Lakshminarasimhaiah

Background: Alpha-2 adrenergic agonists like clonidine and dexmedetomidine prolong the duration of postoperative analgesia and improve the quality of subarachnoid block (SAB) when used as adjuvant in various routes. However, addition of these drugs by IV or intrathecal routes are known to cause hemodynamic instability. The subcutaneous (SC) route provides similar efficacy as IV administration with less hemodynamic instability and prolonged effect. Aims: To compare the efficacy of clonidine and dexmedetomidine as adjuvants to SAB when used subcutaneously. Materials and methods: A total of 90 patients were randomized into one of the three groups: Group P received 1 ml of Normal saline SC, Group D received 0.5 mcg/kg of dexmeditomedine SC and Group C received 1 mcg/kg of clonidine SC respectively after SAB with 3ml of 0.5% hyperbaric bupivacaine (15 mg). Time of onset of sensory and motor block, intraoperative hemodynamics, postoperative VAS scores, Richmond agitation sedation scale, duration of postoperative analgesia and mean paracetamol requirement in 24 hours were recorded. Results: Mean duration of postoperative analgesia was prolonged in group D (838.10±348.22 minutes) and group C (816.67±230.48 minutes) when compared to group P (332.10±110.91 minutes). Total paracetamol consumption was less in group D (1400.00±770.13 mg) and group C (1600.00±674.66 mg), whereas it was 1900.00±758.86 mg in group P. Hemodynamic parameters, maximum sensory level attained, and time to attain maximum sensory levels were comparable among the two groups. Conclusion: Both subcutaneous clonidine and dexmedetomidine prolonged the duration of postoperative analgesia and reduced analgesic requirements when used as adjuvants to SAB with stable hemodynamics, hence both of these drugs can be used effectively as adjuvants to SAB.

背景:克拉定、右美托咪定等α -2肾上腺素能激动剂作为多种途径的辅助用药,可延长术后镇痛时间,改善蛛网膜下腔阻滞(SAB)质量。然而,静脉注射或鞘内注射这些药物会引起血流动力学不稳定。皮下(SC)途径提供与静脉给药相似的疗效,血流动力学不稳定性较小,效果延长。目的:比较可乐定和右美托咪定作为佐剂皮下注射SAB的疗效。材料与方法:90例患者随机分为3组:P组在经0.5%高压布比卡因(15 mg) 3ml SAB后,分别给予生理盐水SC 1 ml,右美托美啶SC 0.5 mcg/kg,可乐定SC 1 mcg/kg。记录感觉和运动阻滞发生时间、术中血流动力学、术后VAS评分、Richmond躁动镇静评分、术后镇痛持续时间、24小时平均扑热息痛需用量。结果:术后平均镇痛时间D组(838.10±348.22 min)、C组(816.67±230.48 min)较P组(332.10±110.91 min)明显延长。D组(1400.00±770.13 mg)和C组(1600.00±674.66 mg)的对乙酰氨基酚总消耗量较低,p组(1900.00±758.86 mg),两组血流动力学参数、达到的最大感觉水平和达到最大感觉水平的时间具有可比性。结论:皮下clonidine和右美托咪定作为SAB的佐剂均可延长术后镇痛时间,减少镇痛需求,血流动力学稳定,可作为SAB的佐剂有效使用。
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引用次数: 3
A clearer view on postoperative cognitive dysfunction? [Letter]. 对术后认知功能障碍有更清晰的认识?(信)。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-03-12 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S201896
Gijsbert J van der Veen, Cornelis Slagt
php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Local and Regional Anesthesia 2019:12 27–28 Local and Regional Anesthesia Dovepress
{"title":"A clearer view on postoperative cognitive dysfunction? [Letter].","authors":"Gijsbert J van der Veen,&nbsp;Cornelis Slagt","doi":"10.2147/LRA.S201896","DOIUrl":"https://doi.org/10.2147/LRA.S201896","url":null,"abstract":"php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Local and Regional Anesthesia 2019:12 27–28 Local and Regional Anesthesia Dovepress","PeriodicalId":18203,"journal":{"name":"Local and Regional Anesthesia","volume":"12 ","pages":"27-28"},"PeriodicalIF":2.9,"publicationDate":"2019-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/LRA.S201896","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37064190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal anesthesia-induced hypotension is caused by a decrease in stroke volume in elderly patients. 脊髓麻醉引起的低血压是由老年患者脑卒中量减少引起的。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-03-04 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S193925
Charlotte Hofhuizen, Joris Lemson, Marc Snoeck, Gert-Jan Scheffer

Background: Hypotension is common during spinal anesthesia (SA) and is caused by a decrease in systemic vascular resistance (SVR) and/or cardiac output (CO). The effect of the dose of bupivacaine administered intrathecally on the changes in CO in elderly patients is largely unknown. This study investigated the hemodynamic effect of SA in elderly patients by studying the effect of two different dosages of intrathecal bupivacaine.

Methods: This prospective cohort study included 64 patients aged >65 years scheduled for procedures under SA; the patients received either 15 mg bupivacaine (the medium dose [MD] group) or 10 mg bupivacaine and 5 μg sufentanil (the low dose [LD] group). Blood pressure and CO were monitored throughout the procedure using Nexfin™, a noninvasive continuous monitoring device using a finger cuff.

Results: Thirty-three patients received MD and 31 received LD and there was no mean difference in baseline hemodynamics between the groups. On an average, the CO decreased 11.6% in the MD group and 10.0 % in the LD group. There was no significant change in SVR. Incidence of a clinically relevant decrease in stroke volume (SV) (>15% from baseline) was 67% in the MD and 45% in the LD groups (P<0.05).

Conclusion: CO and blood pressure decreased significantly after the onset of SA in elderly patients. This is mainly caused by a decrease in SV and not by a decrease in SVR. There was no difference in CO and blood pressure change between dosages of 10 or 15 mg bupivacaine.

背景:低血压在脊髓麻醉(SA)期间很常见,是由全身血管阻力(SVR)和/或心输出量(CO)降低引起的。鞘内布比卡因剂量对老年患者CO变化的影响在很大程度上是未知的。本研究通过研究两种不同剂量的鞘内布比卡因对老年患者SA血流动力学的影响。方法:这项前瞻性队列研究包括64例年龄>65岁的患者,计划在SA下进行手术;患者接受15 mg布比卡因(中剂量[MD]组)或10 mg布比卡因加5 μg舒芬太尼(低剂量[LD]组)治疗。在整个手术过程中,使用Nexfin™(一种使用指套的无创连续监测设备)监测血压和一氧化碳。结果:33例患者接受MD治疗,31例患者接受LD治疗,两组间基线血流动力学无平均差异。MD组的CO平均下降11.6%,LD组的CO平均下降10.0%。SVR无明显变化。临床相关脑卒中体积(SV)下降(比基线>15%)的发生率在MD组为67%,在LD组为45%(结论:老年SA患者发病后CO和血压显著下降。这主要是由于SV的减少而不是SVR的减少造成的。服用10毫克或15毫克布比卡因对CO和血压变化没有影响。
{"title":"Spinal anesthesia-induced hypotension is caused by a decrease in stroke volume in elderly patients.","authors":"Charlotte Hofhuizen,&nbsp;Joris Lemson,&nbsp;Marc Snoeck,&nbsp;Gert-Jan Scheffer","doi":"10.2147/LRA.S193925","DOIUrl":"https://doi.org/10.2147/LRA.S193925","url":null,"abstract":"<p><strong>Background: </strong>Hypotension is common during spinal anesthesia (SA) and is caused by a decrease in systemic vascular resistance (SVR) and/or cardiac output (CO). The effect of the dose of bupivacaine administered intrathecally on the changes in CO in elderly patients is largely unknown. This study investigated the hemodynamic effect of SA in elderly patients by studying the effect of two different dosages of intrathecal bupivacaine.</p><p><strong>Methods: </strong>This prospective cohort study included 64 patients aged >65 years scheduled for procedures under SA; the patients received either 15 mg bupivacaine (the medium dose [MD] group) or 10 mg bupivacaine and 5 μg sufentanil (the low dose [LD] group). Blood pressure and CO were monitored throughout the procedure using Nexfin™, a noninvasive continuous monitoring device using a finger cuff.</p><p><strong>Results: </strong>Thirty-three patients received MD and 31 received LD and there was no mean difference in baseline hemodynamics between the groups. On an average, the CO decreased 11.6% in the MD group and 10.0 % in the LD group. There was no significant change in SVR. Incidence of a clinically relevant decrease in stroke volume (SV) (>15% from baseline) was 67% in the MD and 45% in the LD groups (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>CO and blood pressure decreased significantly after the onset of SA in elderly patients. This is mainly caused by a decrease in SV and not by a decrease in SVR. There was no difference in CO and blood pressure change between dosages of 10 or 15 mg bupivacaine.</p>","PeriodicalId":18203,"journal":{"name":"Local and Regional Anesthesia","volume":"12 ","pages":"19-26"},"PeriodicalIF":2.9,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/LRA.S193925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37064189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
期刊
Local and Regional Anesthesia
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