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Peripheral Neuropathic Pain and Pain Related to Complex Regional Pain Syndrome with and without Fixed Dystonia - Efficient Therapeutic Approach with Local Anesthetics. 伴有或不伴有固定肌张力障碍的周围神经性疼痛和与复杂区域疼痛综合征相关的疼痛——局部麻醉药的有效治疗方法。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2020-01-31 eCollection Date: 2020-01-01 DOI: 10.2147/LRA.S229315
Thomas Michels

Peripheral Neuropathic Pain (PNP) as well as the Complex Regional Pain Syndrome (CRPS), also known as "Reflex Sympathetic Dystrophy", or "Sudeck Dystrophy", all of them have a poor prognosis. The numerous therapeutic offers are rarely accompanied by convincing success over a long duration of time. Even worse is the prognosis of a fixed dystonia which may develop in the extremities of PNP or CRPS patients. In literature a few cases are reported in which the often unbearable pain of those patients with or without a disabling dystonia disappeared immediately after the injection of local anesthetics (LAs) into the scars of a preceding trauma. This review evaluates publications concerning the neuropathological characteristics of fixed dystonia in PNP/CRPS patients and the electrophysiological processes of scar neuromas. The results of these evaluations support the understanding of the therapeutic successes and their immediate results reported above by the injection of LAs into triggering scars. Therapeutic options are discussed.

外周神经性疼痛(PNP)以及复杂区域疼痛综合征(CRPS),又称“反射性交感神经营养不良”或“Sudeck营养不良”,均预后较差。大量的治疗方案很少伴随着长期的令人信服的成功。更糟糕的是,固定肌张力障碍的预后可能发生在PNP或CRPS患者的四肢。在文献中报道了一些病例,这些患者有或没有致残性肌张力障碍,通常难以忍受的疼痛在向先前创伤的疤痕注射局麻药(LAs)后立即消失。本文综述了有关PNP/CRPS患者的固定肌张力障碍的神经病理特征和疤痕性神经瘤的电生理过程的出版物。这些评估的结果支持了上述通过将LAs注射到触发疤痕的治疗成功及其直接结果的理解。讨论了治疗方案。
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引用次数: 1
Non-Operating Room Anesthesia: Patient Selection and Special Considerations. 非手术室麻醉:患者选择和特殊考虑。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2020-01-08 eCollection Date: 2020-01-01 DOI: 10.2147/LRA.S181458
Timothy Wong, Paige L Georgiadis, Richard D Urman, Mitchell H Tsai

Non-operating room anesthesia (NORA) represents a growing field of medicine with an increasing trend in the number of cases performed over the previous decade. As a result, anesthesia providers will need to enhance their familiarity with the resources, personnel, and environment outside of the operating room. Anesthesia delivery in NORA settings should be held with the same high-quality standards as that within the operating room. This review looks at special considerations in patient selection and the preoperative, intraoperative, and postoperative periods. In addition, there is a discussion on the unique aspects of specific NORA areas and the considerations that come with them.

非手术室麻醉(NORA)代表了一个不断发展的医学领域,在过去的十年中,实施的病例数量呈增长趋势。因此,麻醉提供者需要加强对手术室外资源、人员和环境的熟悉。NORA环境下的麻醉交付应与手术室内的麻醉交付具有相同的高质量标准。这篇综述着眼于患者选择和术前、术中、术后时期的特殊考虑。此外,还讨论了NORA具体领域的独特方面以及随之而来的考虑。
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引用次数: 12
Anesthesia for Percutaneous Radiofrequency Tumor Ablation (PRFA): A Review of Current Practice and Techniques. 麻醉经皮射频肿瘤消融(PRFA):当前实践和技术的回顾。
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-12-04 eCollection Date: 2019-01-01 DOI: 10.2147/LRA.S185765
Federico Piccioni, Andrea Poli, Leah Carol Templeton, T Wesley Templeton, Marco Rispoli, Luigi Vetrugno, Domenico Santonastaso, Franco Valenza

Percutaneous radiofrequency ablation (PRFA) of solid tumors is a minimally invasive procedure used to treat primary or metastatic cancer lesions via needle targeted thermal energy transfer. Some of the most common tumor lesions treated using PRFA include those within the liver, lungs and kidneys. Additionally, bone, thyroid, and breast lesions can also be treated. In most cases, this procedure is performed outside of the operating room in a specialized radiology suite. As a result, the clinician must adapt in many cases to the specific environmental issues attendant to providing anesthesia outside the operating room, including the lack of availability of an anesthesia machine in some cases, and frequently a lack of adequate scavenging and other specialized monitoring and equipment. At this time, routine practice and anesthetic prescriptions for PRFA can vary widely, ranging from patients receiving local anesthesia alone, to monitored anesthesia care, to regional anesthesia, to combined regional and general anesthesia. The choice of anesthetic technique will depend on tumor location and practitioner experience. This review aims to summarize the current state of the art in terms of anesthetic techniques for patients undergoing PRFA of solid tumors.

实体瘤经皮射频消融(PRFA)是一种微创手术,用于治疗原发性或转移性癌症病变,通过针靶向热能转移。使用PRFA治疗的一些最常见的肿瘤病变包括肝、肺和肾内的肿瘤病变。此外,骨骼、甲状腺和乳房病变也可以治疗。在大多数情况下,这个过程是在手术室外的一个专门的放射套件中进行的。因此,在许多情况下,临床医生必须适应在手术室外提供麻醉的特定环境问题,包括在某些情况下缺乏麻醉机,并且经常缺乏足够的清除和其他专门的监测和设备。此时,PRFA的常规做法和麻醉处方可能差异很大,从单独接受局部麻醉到监测麻醉护理,再到区域麻醉,再到区域和全身联合麻醉。麻醉技术的选择取决于肿瘤的位置和医生的经验。这篇综述的目的是总结目前的状态,在麻醉技术方面,为患者接受实体瘤PRFA。
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引用次数: 22
Bilateral Brachial Plexus Block Using Chloroprocaine For Surgery Of Bilateral Radial Fractures [Letter] 氯普鲁卡因阻滞治疗双侧桡骨骨折[字母]
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-11-08 DOI: 10.2147/lra.s233411
Eva Hendriksen, C. Slagt
Department Anaesthesia, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, 6500 HB, the Netherlands Dear editor With great interest we have read the article by Mangla et al recently published in Local and Regional Anaesthesia. In this article, they present the anaesthetic considerations of a trauma patient with bilateral radial fractures. Because of posttraumatic orofacial swelling combined with a sore throat after a previous anaesthesia, they anticipated a possible difficult airway. The patient was motivated for a bilateral brachial plexus anaesthesia combined with midazolam and propofol infusion. A infraclavicular block on the right and a supraclavicular block on the left were performed under ultrasound guidance. We would like to share our thoughts regarding this anaesthetic plan with respect to patient safety. Firstly, combining different local anaesthetics is common but their toxicity is additive. Calculating maximal doses becomes blurred. Blocks become unpredictable due to changes in pKa values and alterations in free fractions of these local anaesthetics. Secondly, when pulmonary complications are a real concern we suggest to perform a bilateral axillary block since there are no concerns regarding pulmonal failure (diaphragm palsy, pneumothorax). In combination with a skin ring block to address the intercostobrachial nerve, patients will have sufficient anaesthesia to tolerate a tourniquet (if needed). Third, Mangla et al performed a bilateral brachial block using bupivacaine 0.5%. Regarding LA toxicity, ropivacaine has largely replaced bupivacaine as the most commonly used long-acting local anaesthetic in peripheral nerve blockade. In equivalent doses, it produces less motor blockade compared to bupivacaine but an equally effective sensory block. Most important ropivacaine is less cardiotoxic compared to bupivacaine. The volume of LA that was given to perform the brachial blocks was 30–40mL. An increased volume will increase the spread of local anaesthetics, increasing the chance of blocking the phrenic nerve. Especially as 20 mL of ropivacaine 0.75% or low dose ropivacaine 0.375% is sufficient in a ultrasound guided supraclavicular block. Determining the anaesthetic plan is always a delicate balance between patient wishes, surgical options, surgical and/or anaesthesia risks. Anaesthesiologists should implement the plan that minimizes the risk to the patient.
内梅亨大学医学中心麻醉、疼痛和姑息医学系,奈梅亨,6500 HB,荷兰亲爱的编辑,我们怀着极大的兴趣阅读了Mangla等人最近发表在《局部和区域麻醉》上的文章。在这篇文章中,他们提出了麻醉的考虑创伤患者双侧桡骨骨折。由于创伤后的口面部肿胀和先前麻醉后的喉咙痛,他们预计可能会出现气道困难。患者接受双侧臂丛麻醉联合咪达唑仑和异丙酚输注。在超声引导下行右侧锁骨下阻滞术和左侧锁骨上阻滞术。我们想分享一下我们对麻醉计划的看法考虑到病人的安全。首先,不同局麻药联合使用是常见的,但其毒性是加性的。最大剂量的计算变得模糊。由于pKa值的变化和这些局部麻醉剂游离组分的改变,阻滞变得不可预测。其次,当肺部并发症是一个真正的担忧,我们建议进行双侧腋窝阻滞,因为没有担心肺衰竭(膈肌麻痹,气胸)。结合皮肤环阻滞处理肋间臂神经,患者将有足够的麻醉来耐受止血带(如果需要)。第三,Mangla等人使用0.5%布比卡因进行双侧臂丛阻滞。关于LA的毒性,罗哌卡因已在很大程度上取代布比卡因成为周围神经阻滞中最常用的长效局部麻醉剂。在同等剂量下,与布比卡因相比,它产生的运动阻断较少,但同样有效的感觉阻断。最重要的是,与布比卡因相比,罗哌卡因对心脏的毒性更小。用于肱动脉阻滞的LA体积为30-40mL。体积增加会增加局部麻醉剂的扩散,增加膈神经阻塞的机会。特别是20毫升0.75%的罗哌卡因或0.375%的低剂量罗哌卡因在超声引导下的锁骨上阻滞是足够的。确定麻醉方案总是在患者意愿、手术选择、手术和/或麻醉风险之间取得微妙的平衡。麻醉师应该执行使病人风险最小化的计划。
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引用次数: 0
Bilateral Brachial Plexus Block Using Chloroprocaine For Surgery Of Bilateral Radial Fractures [Response To Letter] 氯洛卡因用于双侧桡骨骨折手术的双侧臂丛阻滞[回复信函]
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-11-01 DOI: 10.2147/lra.s238432
Chanchal Mangla, H. Kamath, J. Yarmush
Department of Anesthesiology, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA Dear editor We would like to thank Dr Hendrickson et al for their interest in our work and writing about their opinion. We agree with the comment that mixing local anesthetics might make individual safe doses unknown, so maximum recommended doses of each local anesthetic should not be used. There are no human studies but it can be presumed to be additive based on some animal studies. We mixed local anesthetics in our patients so that we could decrease the volume of more toxic local anesthetics (Bupivacaine) by using some less toxic ones (like chloroprocaine). We also used doses of each local anesthetic of well below the recommended toxic doses and did spacing in our blocks to avoid toxicity. Though axillary blocks along with medial brachial cutaneous and intercostobrachial block can be used, we chose not to perform bilateral axillary blocks because it requires individual blockage of the terminal nerves which might lead to inadequate coverage, and also, performance of the block time and onset time is longer. Instead, we did infraclavicular block on one side, which greatly decreases the chances of phrenic nerve palsy. Dr Hendricken made a very good point of using ropivacaine instead of bupivacaine due to less toxicity, but unfortunately we do not have ropivacaine available at our institution. Lastly, smaller volume of local anesthetics can be used with the use of ultrasound for a successful block. We used 30 mL volume for each block, as we wanted to ensure complete coverage of surgical anesthesia and to avoid any supplementation/ deeper sedation or general anesthesia in case of an incomplete block. Also, our second block was more than two hours later, hence we avoided the overlap of peak plasma concentration of the local anesthetics from first and second blocks.
美国纽约布鲁克林纽约长老会布鲁克林卫理公会医院麻醉科尊敬的编辑,我们要感谢Hendrickson博士等人对我们的工作感兴趣,并撰写他们的意见。我们同意这样的评论,即混合局部麻醉剂可能会使个人的安全剂量未知,因此不应使用每种局部麻醉剂的最大推荐剂量。目前还没有人类研究,但根据一些动物研究,可以推测它是加性的。我们在患者身上混合了局部麻醉剂,这样我们就可以通过使用一些毒性较小的局部麻醉剂(如氯普鲁卡因)来减少毒性较大的局部麻醉剂的体积(布比卡因)。我们还使用了远低于推荐毒性剂量的每种局部麻醉剂的剂量,并在我们的区块中进行了间隔以避免毒性。虽然可以使用腋窝阻滞以及内侧臂皮肤和肋间臂阻滞,但我们选择不进行双侧腋窝阻滞,因为它需要单独阻断末端神经,这可能导致覆盖不足,而且阻滞时间和起效时间更长。相反,我们在一侧进行了锁骨下阻滞,这大大降低了膈神经麻痹的几率。Hendricken博士非常重视使用罗哌卡因代替布比卡因,因为毒性较小,但不幸的是,我们机构没有罗哌卡因。最后,较小体积的局部麻醉剂可以与超声波一起使用,以成功阻断。我们为每个阻滞使用了30mL的体积,因为我们希望确保手术麻醉的完全覆盖,并避免在阻滞不完全的情况下进行任何补充/更深的镇静或全身麻醉。此外,我们的第二次阻滞是在两个多小时后,因此我们避免了第一次和第二次局部麻醉剂峰值血浆浓度的重叠。
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引用次数: 1
Obesity And Obstetric Anesthesia: Current Insights 肥胖与产科麻醉:最新见解
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-11-01 DOI: 10.2147/LRA.S186530
C. Taylor, J. Dominguez, A. Habib
Abstract Obesity is a significant global health problem. It results in a higher incidence of complications for pregnant women and their neonates. Cesarean deliveries are more common in obese parturients as well. The increased burden of comorbidities seen in this population, such as obstructive sleep apnea, necessitates antepartum anesthetic consultation. These patients pose unique challenges for the practicing anesthesiologist and may benefit from optimization prior to delivery. Complications from anesthesia and overall morbidity and mortality are higher in this population. Neuraxial anesthesia can be challenging to place in the obese parturient, but is the preferred anesthetic for cesarean delivery to avoid airway manipulation, minimize aspiration risk, prevent fetal exposure to volatile anesthetic, and decrease risk of post-partum hemorrhage from volatile anesthetic exposure. Monitoring and positioning of these patients for surgery may pose specific challenges. Functional labor epidural catheters can be topped up to provide conditions suitable for surgery. In the absence of a working epidural catheter, a combined spinal epidural anesthetic is often the technique of choice due to relative ease of placement versus a single shot spinal technique as well as the ability to extend the anesthetic through the epidural portion. For cesarean delivery with a vertical supraumbilical skin incision, a two-catheter technique may be beneficial. Concern for thromboembolism necessitates early mobilization and a multimodal analgesic regimen can help accomplish this. In addition, thromboprophylaxis is recommended in this population after delivery—especially cesarean delivery. These patients also need close monitoring in the post-partum period when they are at increased risk for several complications.
摘要肥胖是一个重要的全球健康问题。这导致孕妇及其新生儿并发症的发生率更高。剖宫产在肥胖产妇中也更常见。这一人群中出现的合并症负担增加,如阻塞性睡眠呼吸暂停,需要进行产前麻醉咨询。这些患者给执业麻醉师带来了独特的挑战,并可能从分娩前的优化中受益。麻醉并发症、总体发病率和死亡率在这一人群中较高。在肥胖产妇中使用轴颈麻醉可能很有挑战性,但它是剖宫产的首选麻醉剂,可以避免气道操作,最大限度地降低抽吸风险,防止胎儿暴露于挥发性麻醉剂,并降低挥发性麻醉剂暴露导致产后出血的风险。对这些患者进行手术监测和定位可能会带来特定的挑战。功能性分娩硬膜外导管可以加满,以提供适合手术的条件。在没有工作的硬膜外导管的情况下,由于与单次注射脊髓技术相比,放置相对容易,并且能够将麻醉剂延伸到硬膜外部分,因此通常选择腰麻-硬膜外联合麻醉技术。对于垂直脐上皮肤切口的剖宫产,双导管技术可能是有益的。对血栓栓塞症的关注需要尽早动员,多模式镇痛方案可以帮助实现这一点。此外,建议在分娩后对这一人群进行血栓预防,尤其是剖宫产。这些患者在产后也需要密切监测,因为他们出现多种并发症的风险增加。
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引用次数: 27
Case Report Of Cryoneurolysis For The Treatment Of Refractory Intercostobrachial Neuralgia With Postherpetic Neuralgia 冷冻神经溶解术治疗顽固性肋间臂神经痛伴带状疱疹后神经痛1例报告
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-11-01 DOI: 10.2147/LRA.S223961
G. Weber, K. Saad, M. Awad, Tiffany H. Wong
Abstract Postherpetic neuralgia is a common and potentially debilitating neuropathic pain condition. Current pharmacologic therapy can be inadequate and intolerable for patients. We present a case of a gentleman with refractory postherpetic neuralgia in the intercostobrachial nerve distribution that was successfully treated with cryoneurolysis/cryoanalgesia therapy.
带状疱疹后神经痛是一种常见的、可能使人衰弱的神经性疼痛。目前的药物治疗对患者来说可能是不充分和无法忍受的。我们提出一个病例的男士顽固性疱疹后神经痛在肋间臂神经分布,成功地治疗了冷冻神经溶解/冷冻镇痛疗法。
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引用次数: 5
Evaluation of the attitudes of surgeons about regional anesthesia: a survey study 外科医生对区域麻醉态度的评价:一项调查研究
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-09-16 DOI: 10.2147/LRA.S211469
Ferda Yılmaz İnal, Yadigar Yılmaz, H. Daşkaya, M. Toptaş, H. Koçoğlu, H. Uysal, I. Akkoc
Background The intraoperative attending anaesthesiologist ultimately makes decisions about the anaesthesiology technique to be performed, but the attitudes of surgeons and preferences of patients on this subject may affect their choice. In this questionnaire-based study, we aimed to evaluate the attitudes and behaviors of surgeons about the use of regional anaesthesia (RA) in surgical operations. Methods Surgeons from different surgical branches with residencies at 4 different hospitals were asked to complete questionnaires that included reasons for preferring (12 reasons) and not preferring (13 reasons) the use of RA techniques for surgeries, using a 5-point Likert scale. Results A total of 156 surgeons from 4 hospitals, out of 167 surgeons who were approached to participate in the study, completed the questionnaire. The most commonly observed reason for a preference towards regional anaesthesia among the surgeons was the risk of general anaesthesia for patients with an American Society of Anesthesiologists (ASA) risk class of III and above. The second most commonly observed reason was for protection from the complications of general anaesthesia, and the third most commonly observed reason was the lower risk of thromboembolisms with regional anaesthesia. The most commonly observed reasons for not choosing regional anaesthesia were found to be incompatibility of the patients and patients’ fears of feeling pain during surgery. Conclusion We conclude that programmes for informing surgeons and educating patients about the advantages of RA may increase the preference ratio among surgeons and decrease patients’ refusals to choose this procedure.
背景术中主治麻醉师最终决定要进行的麻醉术技术,但外科医生的态度和患者对该主题的偏好可能会影响他们的选择。在这项基于问卷的研究中,我们旨在评估外科医生对外科手术中使用区域麻醉(RA)的态度和行为。方法要求居住在4家不同医院的不同外科分支的外科医生使用5分Likert量表填写问卷,其中包括倾向于(12个原因)和不倾向于(13个原因)使用RA技术进行手术的原因。结果在167名参与研究的外科医生中,共有来自4家医院的156名外科医生完成了问卷调查。外科医生偏好区域麻醉的最常见原因是美国麻醉师协会(ASA)风险等级为III级及以上的患者全身麻醉的风险。第二个最常见的原因是预防全身麻醉并发症,第三个最常见原因是区域麻醉导致血栓栓塞的风险较低。不选择区域麻醉的最常见原因是患者的不相容性和患者对手术过程中感到疼痛的恐惧。结论我们的结论是,告知外科医生和教育患者RA的优点的计划可以增加外科医生的偏好比例,并减少患者拒绝选择该手术的情况。
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引用次数: 3
Evaluation Of The Attitudes Of Surgeons About Regional Anesthesia: A Survey Study [Corrigendum] 外科医生对区域麻醉态度的评价:一项调查研究[勘误]
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-09-01 DOI: 10.2147/lra.s231688
Ferda Yılmaz İnal, Yadigar Yılmaz, H. Daşkaya, M. Toptaş, H. Koçoğlu, H. Uysal, I. Akkoc
[This corrects the article DOI: 10.2147/LRA.S211469.].
[这更正了文章DOI: 10.2147/LRA.S211469.]。
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引用次数: 0
Anesthetic techniques: focus on transversus abdominis plane (TAP) blocks 麻醉技术:以腹横面(TAP)阻滞为主
IF 2.9 Q3 ANESTHESIOLOGY Pub Date : 2019-09-01 DOI: 10.2147/LRA.S138537
Deepanshu Mallan, Sandeep Sharan, S. Saxena, T. Singh, .. Faisal
Abstract Transverse abdominis plane (TAP) blocks, over the past decade, have emerged as a reliable tool in multimodal analgesia. Although they block only the somatic component of pain, studies have still revealed a consistent benefit in the first 24–48 hours after surgery in terms of pain scores and overall opioid consumption. The safety and dependability has increased with ultrasound usage. The aim of this review is to help the reader appreciate the applied anatomy required for a TAP block and its congeners, to standardize its nomenclature, and to help choose between variants of a TAP block and its complications and safety profile.
摘要:在过去的十年中,腹横平面(TAP)阻滞已成为一种可靠的多模式镇痛工具。尽管它们只阻断了疼痛的躯体部分,但研究仍然显示,在手术后24-48小时内,就疼痛评分和总体阿片类药物消耗而言,它们仍然有一致的益处。随着超声的使用,安全性和可靠性得到了提高。这篇综述的目的是帮助读者了解TAP块及其同族物所需的应用解剖学,标准化其命名,并帮助在TAP块的变体及其并发症和安全性之间进行选择。
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引用次数: 12
期刊
Local and Regional Anesthesia
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